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Aliases for TRMO Gene

Aliases for TRMO Gene

  • TRNA Methyltransferase O 2 3 4 5
  • C9orf156 3 4
  • Nef (Lentivirus Myristoylated Factor) Associated Protein 1 3
  • Chromosome 9 Open Reading Frame 156 2
  • Nef Associated Protein 1 3
  • Nef-Associated Protein 1 3
  • Thioesterase NAP1 3
  • EC 2.1.1.- 4
  • HSPC219 3
  • NAP1 3

External Ids for TRMO Gene

Previous HGNC Symbols for TRMO Gene

  • C9orf156

Summaries for TRMO Gene

GeneCards Summary for TRMO Gene

TRMO (TRNA Methyltransferase O) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TRMO Gene

  • S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRMO Gene

Genomics for TRMO Gene

Regulatory Elements for TRMO Gene

Promoters for TRMO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRMO on UCSC Golden Path with GeneCards custom track

Genomic Location for TRMO Gene

Chromosome:
9
Start:
97,876,324 bp from pter
End:
97,922,570 bp from pter
Size:
46,247 bases
Orientation:
Minus strand

Genomic View for TRMO Gene

Genes around TRMO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRMO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRMO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRMO Gene

Proteins for TRMO Gene

  • Protein details for TRMO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BU70-TRMO_HUMAN
    Recommended name:
    tRNA (adenine(37)-N6)-methyltransferase
    Protein Accession:
    Q9BU70
    Secondary Accessions:
    • Q5T113
    • Q86SK0
    • Q9NXJ7
    • Q9P0Q7

    Protein attributes for TRMO Gene

    Size:
    441 amino acids
    Molecular mass:
    48587 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAF36139.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAF36139.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence.; Evidence={ECO:0000305};

neXtProt entry for TRMO Gene

Proteomics data for TRMO Gene at MOPED

Post-translational modifications for TRMO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRMO Gene

No data available for DME Specific Peptides for TRMO Gene

Domains & Families for TRMO Gene

Protein Domains for TRMO Gene

Suggested Antigen Peptide Sequences for TRMO Gene

Graphical View of Domain Structure for InterPro Entry

Q9BU70

UniProtKB/Swiss-Prot:

TRMO_HUMAN :
  • Contains 1 TsaA-like domain.
Domain:
  • Contains 1 TsaA-like domain.
genes like me logo Genes that share domains with TRMO: view

No data available for Gene Families for TRMO Gene

Function for TRMO Gene

Molecular function for TRMO Gene

UniProtKB/Swiss-Prot Function:
S-adenosyl-L-methionine-dependent methyltransferase responsible for the addition of the methyl group in the formation of N6-methyl-N6-threonylcarbamoyladenosine at position 37 (m(6)t(6)A37) of the tRNA anticodon loop of tRNA(Ser)(GCU) (PubMed:25063302). The methyl group of m(6)t(6)A37 may improve the efficiency of the tRNA decoding ability. May bind to tRNA (By similarity).

Enzyme Numbers (IUBMB) for TRMO Gene

genes like me logo Genes that share phenotypes with TRMO: view

Animal Model Products

miRNA for TRMO Gene

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRMO Gene

Localization for TRMO Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRMO Gene

Pathways & Interactions for TRMO Gene

SuperPathways for TRMO Gene

No Data Available

Interacting Proteins for TRMO Gene

Gene Ontology (GO) - Biological Process for TRMO Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRMO Gene

Drugs & Compounds for TRMO Gene

(1) Drugs for TRMO Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Propionyl-CoA Experimental Pharma 0

(31) Additional Compounds for TRMO Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(2E)-Decenoyl-CoA
  • (E)-S-2-decenoate
  • (E)-S-2-decenoate CoA
  • (E)-S-2-decenoate Coenzyme A
  • (E)-S-2-decenoic acid
  • 2-trans-Decenoyl-CoA
10018-95-8
(2E)-Dodecenoyl-CoA
  • (2E)-Dodec-2-enoyl-CoA
  • (2E)-Dodec-2-enoyl-Coenzyme A
  • 2-trans-Dodecenoyl-CoA
  • 2-trans-Dodecenoyl-Coenzyme A
1066-12-2
(2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-CoA
  • (2E)-Hexadecenoyl-Coenzyme A
  • trans-2-Hexadecenoyl-CoA
  • trans-2-Hexadecenoyl-Coenzyme A
4460-95-1
(2E)-Octenoyl-CoA
  • (E)-S-2-octenoate
  • (E)-S-2-octenoate CoA
  • (E)-S-2-octenoate Coenzyme A
  • (E)-S-2-octenoic acid
  • 2,3-trans-Octenoyl coenzyme A
10018-94-7
(2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-CoA
  • (2E)-Tetradecenoyl-Coenzyme A
  • Trans-tetra-dec-2-enoyl-CoA
  • Trans-tetra-dec-2-enoyl-CoA.
  • Trans-tetra-dec-2-enoyl-Coenzyme A
38795-33-4
genes like me logo Genes that share compounds with TRMO: view

Transcripts for TRMO Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TRMO Gene

No ASD Table

Relevant External Links for TRMO Gene

GeneLoc Exon Structure for
TRMO
ECgene alternative splicing isoforms for
TRMO

Expression for TRMO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

genes like me logo Genes that share expression patterns with TRMO: view

In Situ Assay Products

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRMO Gene

Orthologs for TRMO Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRMO Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C8H9orf156 35
  • 81.49 (n)
  • 76.5 (a)
C8H9ORF156 36
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C11H9orf156 35
  • 84.77 (n)
  • 79.32 (a)
C9orf156 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 5830415F09Rik 35
  • 78.23 (n)
  • 72.21 (a)
Trmo 16
5830415F09Rik 36
  • 62 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf156 35
  • 99.09 (n)
  • 98.18 (a)
C9orf156 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305420 35
  • 79.04 (n)
  • 74.25 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf156 36
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf156 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf156 35
  • 59.64 (n)
  • 57.33 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.14287 35
zebrafish
(Danio rerio)
Actinopterygii zgc:123172 35
  • 61.52 (n)
  • 60.11 (a)
C1H9orf156 36
  • 38 (a)
OneToOne
Species with no ortholog for TRMO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRMO Gene

ENSEMBL:
Gene Tree for TRMO (if available)
TreeFam:
Gene Tree for TRMO (if available)

Paralogs for TRMO Gene

No data available for Paralogs for TRMO Gene

Variants for TRMO Gene

Sequence variations from dbSNP and Humsavar for TRMO Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs3183927 - 97,922,475(-) AGGAG(C/T)CGGGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs35606344 - 97,910,271(+) AATCC(A/G)CTGCT nc-transcript-variant, reference, missense
rs2282192 - 97,910,056(+) AACCA(C/T)GCTGC nc-transcript-variant, reference, missense
rs6586 -- 97,904,649(-) GTGTC(A/G)AGAAG intron-variant, utr-variant-3-prime
rs723227 -- 97,906,791(+) GAGCC(A/G)AGATC intron-variant

Variation tolerance for TRMO Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.01; 74.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRMO Gene

HapMap Linkage Disequilibrium report
TRMO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRMO Gene

Disorders for TRMO Gene

Relevant External Links for TRMO

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRMO

No disorders were found for TRMO Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRMO Gene

Publications for TRMO Gene

  1. Discovery of the I^-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs. (PMID: 25063302) Kimura S. … Suzuki T. (Nucleic Acids Res. 2014) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N. … Do C.B. (PLoS ONE 2012) 3
  4. The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl. (PMID: 20350937) Takahashi M. … Yamashita S. (Hum. Mol. Genet. 2010) 3
  5. Follow-up association studies of chromosome region 9q and nonsyndromic cleft lip/palate. (PMID: 20583170) Letra A. … Vieira A.R. (Am. J. Med. Genet. A 2010) 3

Products for TRMO Gene

Sources for TRMO Gene

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