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TRIT1 Gene

protein-coding   GIFtS: 59
GCID: GC01M040306

TRNA Isopentenyltransferase 1

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRNA Isopentenyltransferase 11 2     IPP Transferase2 3
Isopentenyl-Diphosphate:TRNA Isopentenyltransferase2 3     TRNA Dimethylallyltransferase, Mitochondrial2
IPPT2 3     TRNA Isopentenylpyrophosphate Transferase2
IPT2 3     EC 2.5.1.753
IPTase2 3     TRNA Isopentenyltransferase3
MOD52 3     EC 2.5.1.88
hGRO12 3     

External Ids:    HGNC: 202861   Entrez Gene: 548022   Ensembl: ENSG000000435147   UniProtKB: Q9H3H13   

Export aliases for TRIT1 gene to outside databases

Previous GC identifers: GC01M039720 GC01M039975 GC01M040081 GC01M038425


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIT1 Gene:
TRIT1 (tRNA isopentenyltransferase 1) is a protein-coding gene. Diseases associated with TRIT1 include tinea pedis, and labyrinthitis. GO annotations related to this gene include tRNA dimethylallyltransferase activity.

UniProtKB/Swiss-Prot: MOD5_HUMAN, Q9H3H1
Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and
mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)

Gene Wiki entry for TRIT1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIT1 gene promoter:
         p53   AP-1   AML1a   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIT1 promoter sequence
   Search Chromatin IP Primers for TRIT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34.2   Ensembl cytogenetic band:  1p34.2   HGNC cytogenetic band: 1p34.2

TRIT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIT1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M040306:  view genomic region     (about GC identifiers)

Start:
40,306,703 bp from pter      End:
40,349,183 bp from pter
Size:
42,481 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: MOD5_HUMAN, Q9H3H1 (See protein sequence)
Recommended Name: tRNA dimethylallyltransferase, mitochondrial precursor  
Size: 467 amino acids; 52725 Da
Secondary accessions: A1A4X7 Q3T7B5 Q5QPK5 Q5QPK6 Q6IAC9 Q96FJ3 Q96L45 Q9NXT7
Alternative splicing: 6 isoforms:  Q9H3H1-1   Q9H3H1-2   Q9H3H1-3   Q9H3H1-4   Q9H3H1-5   Q9H3H1-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIT1: NX_Q9H3H1

Explore proteomics data for TRIT1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys391
  • Modification sites at PhosphoSitePlus
  • 2 DME Specific Peptides for TRIT1 (Q9H3H1)
     EIVSADS  PIVVGGT 


    See TRIT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060116.2  
    ENSEMBL proteins: 
     ENSP00000388333   ENSP00000473773   ENSP00000321810   ENSP00000361905   ENSP00000474264  
     ENSP00000473708   ENSP00000473745   ENSP00000474151   ENSP00000474768   ENSP00000439596  
     ENSP00000437700   ENSP00000440865   ENSP00000437896   ENSP00000442765  

    TRIT1 Human Recombinant Protein Products:

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    Novus Biologicals TRIT1 Protein
    Novus Biologicals TRIT1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIT1

    TRIT1 Antibody Products:

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    TRIT1 Assay Products:

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    GenScript Custom Assay Services for TRIT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIT1
    Cloud-Clone Corp. CLIAs for TRIT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR002627 IPPT
     IPR027417 P-loop_NTPase
     IPR018022 tRNA_delta_PyrP_Trfase
     IPR022755 Znf_C2H2_jaz

    Graphical View of Domain Structure for InterPro Entry Q9H3H1

    ProtoNet protein and cluster: Q9H3H1

    1 Blocks protein domain: IPB002627 tRNA isopentenyltransferase

    UniProtKB/Swiss-Prot: MOD5_HUMAN, Q9H3H1
    Similarity: Belongs to the IPP transferase family
    Similarity: Contains 1 matrin-type zinc finger


    TRIT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: MOD5_HUMAN, Q9H3H1
    Function: Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and
    mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
    Catalytic activity: Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N(6)-dimethylallyladenine(37)
    in tRNA

         Enzyme Numbers (IUBMB): EC 2.5.1.82 EC 2.5.1.751

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding ----
    GO:0004161dimethylallyltranstransferase activity ----
    GO:0005524ATP binding IEA--
    GO:0008270zinc ion binding ----
    GO:0016740transferase activity ----
         
    TRIT1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIT1
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIT1

    miRNA
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    miRTarBase miRNAs that target TRIT1:
    hsa-mir-183-5p (MIRT047047), hsa-mir-3615 (MIRT052858)

    Block miRNA regulation of human, mouse, rat TRIT1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TRIT1:
    hsa-miR-875-3p hsa-miR-370 hsa-miR-1283 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTRIT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIT1
    Predesigned siRNA for gene silencing in human, mouse, rat TRIT1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TRIT1

    Clone
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    OriGene clones in human, mouse for TRIT1 (see all 9)
    OriGene ORF clones in mouse, rat for TRIT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIT1 (NM_017646)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIT1

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TRIT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    MOD5_HUMAN, Q9H3H1: Isoform 1: Mitochondrion (Potential)
    MOD5_HUMAN, Q9H3H1: Isoform 4: Mitochondrion (Potential)
    MOD5_HUMAN, Q9H3H1: Isoform 2: Cytoplasm (Potential)
    MOD5_HUMAN, Q9H3H1: Isoform 3: Cytoplasm (Potential)
    MOD5_HUMAN, Q9H3H1: Isoform 5: Cytoplasm (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion3
    nucleus3
    chloroplast1
    cytosol1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005575cellular_component ND--
    GO:0005739mitochondrion IEA--

    TRIT1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIT1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Metabolism
    Metabolic pathways0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TRIT1):
        Metabolic pathways


    TRIT1 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIT1
    Interactions:

        Search GeneGlobe Interaction Network for TRIT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    Selected Interacting proteins for TRIT1 (Q9H3H12, 3 ENSP000003218104) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FAM203AQ9BTY72, 3, ENSP000003213204MINT-65346 I2D: score=4 STRING: ENSP00000321320
    GFM1Q96RP93, ENSP000004190384I2D: score=1 STRING: ENSP00000419038
    HIRAP541983, ENSP000002632084I2D: score=1 STRING: ENSP00000263208
    KIAA0020Q153973, ENSP000003809824I2D: score=1 STRING: ENSP00000380982
    METTL1Q9UBP63, ENSP000003144414I2D: score=1 STRING: ENSP00000314441
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008033tRNA processing IEA--
    GO:0009058biosynthetic process ----

    TRIT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIT1 (MOD5)

    3 HMDB Compounds for TRIT1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Isopentenyl pyrophosphate3-Methyl-3-butenyl pyrophosphate (see all 13)358-71-4--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    2 Novoseek inferred chemical compound relationships for TRIT1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isopentenyladenosine 88.3 2 12529525 (1)
    cytokinin 77 2 19568949 (1), 16546001 (1)



    TRIT1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIT1 gene: 
    NM_017646.4  

    Unigene Cluster for TRIT1:

    TRNA isopentenyltransferase 1
    Hs.356554  [show with all ESTs]
    Unigene Representative Sequence: AF074918
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000441669 ENST00000462797 ENST00000316891(uc001cei.4 uc001cec.4 uc001ced.4 uc001cee.4 uc001cef.4 uc001ceg.4 uc001ceh.4 uc021olz.1)
    ENST00000372818 ENST00000495175 ENST00000491865 ENST00000465417 ENST00000492612
    ENST00000467774 ENST00000489945 ENST00000486825 ENST00000469476 ENST00000462243
    ENST00000545233 ENST00000537440 ENST00000537223 ENST00000541099 ENST00000544981

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat TRIT1 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate TRIT1:
    hsa-miR-875-3p hsa-miR-370 hsa-miR-1283 hsa-miR-1299
    SwitchGear 3'UTR luciferase reporter plasmidTRIT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIT1
    Predesigned siRNA for gene silencing in human, mouse, rat TRIT1
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIT1 (NM_017646)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIT1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIT1
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIT1
      QuantiTect SYBR Green Assays in human, mouse, rat TRIT1
      QuantiFast Probe-based Assays in human, mouse, rat TRIT1

    Additional mRNA sequence: 

    AF074918.1 AK000068.1 AK074222.1 AK223478.1 AK296453.1 AK304759.1 AK307910.1 AY052768.1 
    AY303390.1 AY702933.1 AY702935.1 AY702941.1 AY702942.1 AY702943.1 AY702944.1 AY702945.1 
    AY702946.1 AY702947.1 BC010741.1 BC107569.1 BC128155.1 

    18 DOTS entries:

    DT.215032  DT.100786580  DT.91979289  DT.92071110  DT.121389206  DT.95265014  DT.91753498  DT.95226261 
    DT.100786583  DT.97811622  DT.121389252  DT.40131691  DT.40212724  DT.92037058  DT.97793818  DT.92012639 
    DT.92071099  DT.92002175 

    Selected AceView cDNA sequences (see all 150):

    AA552721 AI193562 AK000068 N29610 BX338423 BP870781 BU674305 BX360484 
    BM721352 AU279865 CR614254 BC010741 AI347522 CR604485 BQ003256 AW104415 
    AA833930 BM975520 AA043763 AA910391 AK074222 BP344595 AI445520 BM141903 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIT1 (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
    SP1:                          -                       -                 -           -                                   -                 -                     
    SP2:                          -                       -                 -           -                                   -                 -                     
    SP3:                          -                       -                 -           -                       -     -     -                 -                     
    SP4:                          -                       -     -     -     -           -                                   -                 -                     
    SP5:                          -                       -     -     -     -           -                                   -                 -                     


    ECgene alternative splicing isoforms for TRIT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIT1 expression in normal human tissues (normalized intensities)      TRIT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGAGTTAT
    TRIT1 Expression
    About this image


    TRIT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Lung (Respiratory System)
             Stem Bronchi
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Brain (Nervous System)
             Cerebral Cortex
    TRIT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.356554
        Custom PCR Arrays for TRIT1
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIT1
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIT1
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    QuantiFast Probe-based Assays in human, mouse, rat TRIT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIT1 gene from Selected species (see all 23)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trit11 , 5 tRNA isopentenyltransferase 11, 5 87.44(n)1
    89.29(a)1
      4 (57.36 cM)5
    669661  NM_025873.21  NP_080149.21 
     1230165975 
    chicken
    (Gallus gallus)
    Aves TRIT11 tRNA isopentenyltransferase 1 72.54(n)
    73.78(a)
      419678  XM_004947886.1  XP_004947943.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIT16
    tRNA isopentenyltransferase 1
    62(a)
    1 ↔ 1
    GL343481.1(97383-114408)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ037120.12   -- 75.53(n)    BJ037120.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.114952 Transcribed sequence with weak similarity to protein more 76.45(n)    BG728220.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG313811 CG31381 50.43(n)
    43.29(a)
      192528  NM_001202354.2  NP_001189283.1 
    worm
    (Caenorhabditis elegans)
    Secernentea gro-11 gro-1 46.89(n)
    35.86(a)
      175725  NM_065721.4  NP_498122.2 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MOD51 MOD5 46.53(n)
    38.82(a)
      854448   NP_014917.3 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons IPT21 IPT2 47.17(n)
    32.66(a)
      817322  NM_128335.1  NP_565658.1 
    rice
    (Oryza sativa)
    Liliopsida Os01g09687001 Os01g0968700 48.88(n)
    34.74(a)
      4323831  NM_001052055.1  NP_001045520.1 


    ENSEMBL Gene Tree for TRIT1 (if available)
    TreeFam Gene Tree for TRIT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIT1 (see all 1012)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs740697091,2
    C--40306324(+) GTTAAC/TGCTTA 1 -- ds50013Minor allele frequency- T:0.07WA EA 240
    rs802193521,2
    F--40306424(+) AATTAT/GACCCT 1 -- ds50011Minor allele frequency- G:0.01WA 118
    rs1900853731,2
    --40306449(+) TGATGA/TTATAT 1 -- ds50010--------
    rs1485589291,2
    --40306454(+) TTATAA/TATAAA 1 -- ds50010--------
    rs1429379291,2
    --40306703(+) ATATCG/TTTTTA 1 -- ut310--------
    rs1834207061,2
    --40306740(+) TTTCTA/TTATTT 1 -- ut310--------
    rs1875399711,2
    --40306770(+) GATTTA/GTAACT 1 -- ut310--------
    rs1911392251,2
    --40306806(+) ACTCAC/TACATG 1 -- ut310--------
    rs10438431,2
    C,F,A,H--40306865(-) ACTGAG/AGAAGC 1 -- ut31 ese320Minor allele frequency- A:0.13MN NA NS EA WA 2286
    rs73151,2
    C,F,A,H--40306898(-) TTCTCG/AGAATT 1 -- ut31 ese327Minor allele frequency- A:0.46MN EA NA NS WA CSA 4313

    HapMap Linkage Disequilibrium report for TRIT1 (40306703 - 40349183 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIT1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2666580CNV Deletion23128226
    dgv15n27CNV Gain19166990
    dgv49e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIT1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    8 diseases for TRIT1:    About MalaCards
    tinea pedis    labyrinthitis    pneumonia    tuberculosis
    lung cancer    cerebritis    breast cancer    thyroiditis

    1 disease from the University of Copenhagen DISEASES database for TRIT1:
    Tinea pedis

    TRIT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIT1
    Human Genome Epidemiology (HuGE) Navigator: TRIT1 (4 documents)

    Export disorders for TRIT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIT1 gene, integrated from 10 sources (see all 30):
    (articles sorted by number of sources associating them with TRIT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a human tRNA isopentenyl transferase. (PubMed id 11111046)1, 2, 3, 9 Golovko A.... Nicander B. (Gene 2000)
    2. Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer. (PubMed id 15870694)1, 2, 3 Spinola M.... Dragani T.A. (Oncogene 2005)
    3. Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival. (PubMed id 17145094)1, 4, 9 Spinola M....Dragani T.A. (Lung Cancer 2007)
    4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    5. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1, 4 Bhatti P....Sigurdson A.J. (Radiat. Res. 2010)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 54802 HGNC: 20286 AceView: TRIT1 Ensembl:ENSG00000043514 euGenes: HUgn54802
    ECgene: TRIT1 Kegg: 54802 H-InvDB: TRIT1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIT1 gene:
    Search GeneIP for patents involving TRIT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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