Aliases for TRIT1 Gene
External Ids for TRIT1 Gene
Previous GeneCards Identifiers for TRIT1 Gene
This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]
GeneCards Summary for TRIT1 Gene
TRIT1 (TRNA Isopentenyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include nucleic acid binding and dimethylallyltranstransferase activity.
UniProtKB/Swiss-Prot for TRIT1 Gene
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).