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Aliases for TRIT1 Gene

Aliases for TRIT1 Gene

  • TRNA Isopentenyltransferase 1 2 3 5
  • Isopentenyl-Diphosphate:TRNA Isopentenyltransferase 3 4
  • IPP Transferase 3 4
  • IPTase 3 4
  • HGRO1 3 4
  • IPPT 3 4
  • MOD5 3 4
  • IPT 3 4
  • TRNA Dimethylallyltransferase, Mitochondrial 3
  • TRNA Isopentenylpyrophosphate Transferase 3
  • TRNA Isopentenyltransferase 4
  • EC 2.5.1.75 4
  • EC 2.5.1.8 61
  • GRO1 3

External Ids for TRIT1 Gene

Previous GeneCards Identifiers for TRIT1 Gene

  • GC01M039720
  • GC01M039975
  • GC01M040081
  • GC01M040306
  • GC01M038425

Summaries for TRIT1 Gene

Entrez Gene Summary for TRIT1 Gene

  • This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]

GeneCards Summary for TRIT1 Gene

TRIT1 (TRNA Isopentenyltransferase 1) is a Protein Coding gene. Among its related pathways are Gene Expression and tRNA processing. GO annotations related to this gene include nucleic acid binding and dimethylallyltranstransferase activity.

UniProtKB/Swiss-Prot for TRIT1 Gene

  • Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).

Gene Wiki entry for TRIT1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIT1 Gene

Genomics for TRIT1 Gene

Regulatory Elements for TRIT1 Gene

Enhancers for TRIT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G039845 1.5 Ensembl ENCODE dbSUPER 31 +37.1 37093 2.7 FOXA2 PKNOX1 ZNF133 SIN3A FEZF1 TCF12 ZNF121 ZNF143 FOS CAVIN1 TRIT1 PPIEL NFYC-AS1 ENSG00000182109 EXO5 MYCL GC01P039840 ENSG00000202222 GC01M039882
GH01G039851 1.3 ENCODE dbSUPER 31 +31.1 31116 1.3 HNRNPUL1 PKNOX1 FOXA2 MLX ARID4B FEZF1 ZNF2 YY1 FOS MXD4 TRIT1 RPS2P12 GC01P039840 ENSG00000202222 GC01M039882
GH01G039842 1.2 Ensembl ENCODE dbSUPER 31.3 +40.5 40451 1.6 BCOR ZNF263 ZMYM3 ZNF398 NR3C1 NR2F2 ZNF592 POLR2A SMARCA4 SCRT2 TRIT1 ENSG00000202222 LOC105378668 CAP1 GC01P039840 GC01M039882
GH01G039906 1.1 dbSUPER 33.8 -24.3 -24342 2.5 HDGF PKNOX1 CREB3L1 ARNT AGO1 ARID4B SIN3A FEZF1 ZNF2 YY1 EXO5 TRIT1 PPIEL PABPC4 NFYC-AS1 ENSG00000182109 ENSG00000202222 CAP1 RLF MYCL
GH01G039816 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.3 +66.2 66242 2.0 HDGF PKNOX1 FOXA2 ATF1 ARID4B ZNF2 ZNF121 ZNF766 ZNF143 FOS TRIT1 OXCT2 PPIE MACF1 TMCO2 RLF MFSD2A PABPC4 GC01P039816 GC01P039821
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIT1 on UCSC Golden Path with GeneCards custom track

Promoters for TRIT1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000005130 411 1401 HDGF PKNOX1 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766

Genomic Location for TRIT1 Gene

Chromosome:
1
Start:
39,841,022 bp from pter
End:
39,883,511 bp from pter
Size:
42,490 bases
Orientation:
Minus strand

Genomic View for TRIT1 Gene

Genes around TRIT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIT1 Gene

Proteins for TRIT1 Gene

  • Protein details for TRIT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H3H1-MOD5_HUMAN
    Recommended name:
    tRNA dimethylallyltransferase, mitochondrial
    Protein Accession:
    Q9H3H1
    Secondary Accessions:
    • A1A4X7
    • Q3T7B5
    • Q5QPK5
    • Q5QPK6
    • Q6IAC9
    • Q96FJ3
    • Q96L45
    • Q9NXT7

    Protein attributes for TRIT1 Gene

    Size:
    467 amino acids
    Molecular mass:
    52725 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIT1 Gene

neXtProt entry for TRIT1 Gene

Selected DME Specific Peptides for TRIT1 Gene

Q9H3H1:
  • PIVVGGT
  • EIVSADS

Post-translational modifications for TRIT1 Gene

  • Ubiquitination at isoforms=2, 3, 4, 5, 6391
  • Modification sites at PhosphoSitePlus

Domains & Families for TRIT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9H3H1

UniProtKB/Swiss-Prot:

MOD5_HUMAN :
  • Belongs to the IPP transferase family.
Family:
  • Belongs to the IPP transferase family.
genes like me logo Genes that share domains with TRIT1: view

No data available for Gene Families for TRIT1 Gene

Function for TRIT1 Gene

Molecular function for TRIT1 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Dimethylallyl diphosphate + adenine(37) in tRNA = diphosphate + N(6)-dimethylallyladenine(37) in tRNA.
UniProtKB/Swiss-Prot Function:
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).

Enzyme Numbers (IUBMB) for TRIT1 Gene

Gene Ontology (GO) - Molecular Function for TRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0004161 dimethylallyltranstransferase activity IEA --
GO:0005524 ATP binding IEA --
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRIT1: view
genes like me logo Genes that share phenotypes with TRIT1: view

Animal Model Products

CRISPR Products

miRNA for TRIT1 Gene

miRTarBase miRNAs that target TRIT1

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIT1 Gene

Localization for TRIT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIT1 Gene

Isoform 1: Mitochondrion.
Isoform 4: Mitochondrion.
Isoform 2: Cytoplasm.
Isoform 3: Cytoplasm.
Isoform 5: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIT1 gene
Compartment Confidence
mitochondrion 5
nucleus 4
cytosol 3
golgi apparatus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005759 mitochondrial matrix TAS --
genes like me logo Genes that share ontologies with TRIT1: view

Pathways & Interactions for TRIT1 Gene

genes like me logo Genes that share pathways with TRIT1: view

Pathways by source for TRIT1 Gene

Gene Ontology (GO) - Biological Process for TRIT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008033 tRNA processing IEA --
GO:0009058 biosynthetic process IEA --
GO:0070900 mitochondrial tRNA modification TAS --
genes like me logo Genes that share ontologies with TRIT1: view

No data available for SIGNOR curated interactions for TRIT1 Gene

Drugs & Compounds for TRIT1 Gene

(3) Drugs for TRIT1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
DIMETHYLALLYL DIPHOSPHATE Experimental Pharma Competitive, Inhibitor 0
Isopentenyl pyrophosphate Experimental Pharma 0

(3) Additional Compounds for TRIT1 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with TRIT1: view

Transcripts for TRIT1 Gene

Unigene Clusters for TRIT1 Gene

TRNA isopentenyltransferase 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIT1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d ^ 6 ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c
SP1: - - - - - -
SP2: - - - - - -
SP3: - - - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - -
SP6: - - - - - - - -
SP7: - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - - - -
SP10: - - - - - - - - - - -
SP11: - - - - - - - - - - -
SP12: - - - - - - - - - - - -
SP13: - - - - - - - - - - - -
SP14: - - - - - - - - - - - - -
SP15: -
SP16: - - - - - - -
SP17: - - - - - - - - - - - - - - - - -
SP18: -
SP19:
SP20:
SP21: - - - - - - - - - - - - - - - - - - -
SP22:

Relevant External Links for TRIT1 Gene

GeneLoc Exon Structure for
TRIT1
ECgene alternative splicing isoforms for
TRIT1

Expression for TRIT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIT1 Gene

This gene is overexpressed in Pancreatic juice (67.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIT1 Gene



Protein tissue co-expression partners for TRIT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIT1 Gene:

TRIT1

SOURCE GeneReport for Unigene cluster for TRIT1 Gene:

Hs.356554

Evidence on tissue expression from TISSUES for TRIT1 Gene

  • Intestine(4.2)
  • Kidney(4.2)
  • Lung(4.2)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with TRIT1: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIT1 Gene

Orthologs for TRIT1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRIT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIT1 34 35
  • 99.64 (n)
dog
(Canis familiaris)
Mammalia TRIT1 34 35
  • 90.94 (n)
cow
(Bos Taurus)
Mammalia TRIT1 34 35
  • 90.72 (n)
mouse
(Mus musculus)
Mammalia Trit1 34 16 35
  • 87.44 (n)
rat
(Rattus norvegicus)
Mammalia Trit1 34
  • 86.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIT1 35
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIT1 35
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIT1 34 35
  • 72.54 (n)
lizard
(Anolis carolinensis)
Reptilia TRIT1 35
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trit1 34
  • 66.05 (n)
Str.20035 34
zebrafish
(Danio rerio)
Actinopterygii trit1 34 35
  • 62.72 (n)
Dr.11495 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000639 34
  • 50.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG31381 34 35
  • 50.43 (n)
worm
(Caenorhabditis elegans)
Secernentea gro-1 34 35
  • 46.89 (n)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C07359g 34
  • 49.21 (n)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AER341W 34
  • 47.07 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MOD5 34 35
  • 46.53 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons IPT2 34
  • 47.17 (n)
rice
(Oryza sativa)
Liliopsida Os01g0968700 34
  • 48.88 (n)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes tit1 34
  • 46.89 (n)
bread mold
(Neurospora crassa)
Ascomycetes NCU10185 34
  • 45.3 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.6808 35
  • 40 (a)
OneToOne
Species where no ortholog for TRIT1 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIT1 Gene

ENSEMBL:
Gene Tree for TRIT1 (if available)
TreeFam:
Gene Tree for TRIT1 (if available)

Paralogs for TRIT1 Gene

No data available for Paralogs for TRIT1 Gene

Variants for TRIT1 Gene

Sequence variations from dbSNP and Humsavar for TRIT1 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000048679 -- 39,881,477(+) TGCAA(C/T)TGAAC intron-variant
rs1000093057 -- 39,875,473(+) ACAGA(C/G)CGAGA intron-variant
rs1000129359 -- 39,884,526(+) TAATC(C/G)CAGCT upstream-variant-2KB
rs1000204220 -- 39,880,160(+) CAGAG(C/T)AATAC intron-variant
rs1000287360 -- 39,841,352(+) GAAAT(C/T)AGATA nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIT1 Gene

Variant ID Type Subtype PubMed ID
dgv153n100 CNV gain 25217958
dgv15n27 CNV gain 19166990
esv2666580 CNV deletion 23128226
esv2758933 CNV loss 17122850
esv3585792 CNV loss 21293372
nsv1122334 CNV deletion 24896259
nsv546063 CNV gain 21841781

Variation tolerance for TRIT1 Gene

Residual Variation Intolerance Score: 68.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.41; 77.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIT1 Gene

Disorders for TRIT1 Gene

Relevant External Links for TRIT1

Genetic Association Database (GAD)
TRIT1
Human Genome Epidemiology (HuGE) Navigator
TRIT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIT1

No disorders were found for TRIT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIT1 Gene

Publications for TRIT1 Gene

  1. Cloning of a human tRNA isopentenyl transferase. (PMID: 11111046) Golovko A. … Nicander B. (Gene 2000) 2 3 4 22 64
  2. Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival. (PMID: 17145094) Spinola M. … Dragani T.A. (Lung Cancer 2007) 3 22 46 64
  3. Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer. (PMID: 15870694) Spinola M. … Dragani T.A. (Oncogene 2005) 2 3 4 64
  4. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PMID: 20095854) Bhatti P. … Sigurdson A.J. (Radiat. Res. 2010) 3 46 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for TRIT1 Gene

Sources for TRIT1 Gene

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