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Aliases for TRIR Gene

Aliases for TRIR Gene

  • Telomerase RNA Component Interacting RNase 2 3 5
  • C19orf43 3 4
  • Functional Spliceosome-Associated Protein 18 2
  • Chromosome 19 Open Reading Frame 43 2
  • Uncharacterized Protein C19orf43 3
  • My029 Protein 3
  • TERCIR 3
  • FSAP18 3

External Ids for TRIR Gene

Previous HGNC Symbols for TRIR Gene

  • C19orf43

Summaries for TRIR Gene

GeneCards Summary for TRIR Gene

TRIR (Telomerase RNA Component Interacting RNase) is a Protein Coding gene.

Additional gene information for TRIR Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIR Gene

Genomics for TRIR Gene

Regulatory Elements for TRIR Gene

Enhancers for TRIR Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H012781 1.9 FANTOM5 ENCODE dbSUPER 47.4 -54.5 -54523 16 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D ZNF610 ZNF136 CCDC130 ZNF791 ZNF44 ZNF442 ZNF564 TRMT1 ZNF844 TRIR ZNF700
GH19H013148 2.1 FANTOM5 Ensembl ENCODE dbSUPER 39.8 -418.9 -418920 10.2 MLX DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 ZFP41 MEF2D ZNF610 ZNF136 CCDC130 TRMT1 ZNF709 ZNF564 ZNF791 ZNF44 ZNF442 TRIR ZNF625
GH19H012983 2 FANTOM5 Ensembl ENCODE dbSUPER 36.1 -250.0 -250028 3.2 HDGF PKNOX1 FOXA2 MLX SIN3A ARID4B DMAP1 ZNF2 ZNF766 ZNF143 ZNF136 ZNF442 CCDC130 ZNF564 ZNF625 ZNF844 ZNF799 WDR83OS MRI1 ZNF44
GH19H013160 2.1 FANTOM5 Ensembl ENCODE dbSUPER 31.7 -432.5 -432521 13.8 MLX ZFP64 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC ZC3H11A GLIS1 CCDC130 ZNF44 ZNF791 ZNF799 ZNF564 WDR83OS TRIR TRMT1 DCAF15 MRI1
GH19H013632 1.5 Ensembl ENCODE dbSUPER 32.4 -898.5 -898472 1.7 PKNOX1 ZFP64 ZNF133 FEZF1 GLIS2 KLF7 YY2 ZC3H11A NFYC REST CCDC130 MRI1 WDR83OS TRMT1 TRIR RPS6P25 SYCE2 RFX1 MAN2B1 SNRPGP15
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIR on UCSC Golden Path with GeneCards custom track

Promoters for TRIR Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107294 475 1801 HDGF PKNOX1 FOXA2 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Locations for TRIR Gene

Genomic Locations for TRIR Gene
chr19:12,730,640-12,734,775
(GRCh38/hg38)
Size:
4,136 bases
Orientation:
Minus strand
chr19:12,841,454-12,845,589
(GRCh37/hg19)

Genomic View for TRIR Gene

Genes around TRIR on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIR Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIR Gene

Proteins for TRIR Gene

  • Protein details for TRIR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BQ61-CS043_HUMAN
    Recommended name:
    Uncharacterized protein C19orf43
    Protein Accession:
    Q9BQ61

    Protein attributes for TRIR Gene

    Size:
    176 amino acids
    Molecular mass:
    18419 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIR Gene

Post-translational modifications for TRIR Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIR Gene

No data available for DME Specific Peptides for TRIR Gene

Domains & Families for TRIR Gene

Gene Families for TRIR Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for TRIR Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIR: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TRIR Gene

Function for TRIR Gene

Phenotypes From GWAS Catalog for TRIR Gene

Gene Ontology (GO) - Molecular Function for TRIR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TRIR: view
genes like me logo Genes that share phenotypes with TRIR: view

Animal Model Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIR Gene

Localization for TRIR Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIR gene
Compartment Confidence
nucleus 3
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIR Gene

Pathways & Interactions for TRIR Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIR Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIR Gene

Drugs & Compounds for TRIR Gene

No Compound Related Data Available

Transcripts for TRIR Gene

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIR Gene

No ASD Table

Relevant External Links for TRIR Gene

GeneLoc Exon Structure for
TRIR
ECgene alternative splicing isoforms for
TRIR

Expression for TRIR Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIR Gene:

TRIR

Evidence on tissue expression from TISSUES for TRIR Gene

  • Nervous system(2.9)
  • Intestine(2.8)
  • Muscle(2.7)
  • Spleen(2.7)
  • Liver(2.6)
  • Lung(2.6)
  • Heart(2.5)
  • Kidney(2.5)
  • Blood(2.2)
  • Thyroid gland(2)
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIR Gene

Orthologs for TRIR Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf43 33
  • 100 (n)
C19orf43 34
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C7H19orf43 34 33
  • 93.56 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C20H19orf43 33
  • 93.18 (n)
C19orf43 34
  • 67 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 2310036O22Rik 33 34
  • 92.05 (n)
Trir 16
rat
(Rattus norvegicus)
Mammalia RGD1564093 33
  • 91.28 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 71 (a)
OneToMany
-- 34
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia C19orf43 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.528 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.6514 33
zebrafish
(Danio rerio)
Actinopterygii LOC560758 33
  • 56.77 (n)
C3H19orf43 34
  • 46 (a)
OneToOne
Dr.15916 33
fruit fly
(Drosophila melanogaster)
Insecta CG18809 34
  • 18 (a)
OneToOne
Species where no ortholog for TRIR was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIR Gene

ENSEMBL:
Gene Tree for TRIR (if available)
TreeFam:
Gene Tree for TRIR (if available)

Paralogs for TRIR Gene

No data available for Paralogs for TRIR Gene

Variants for TRIR Gene

Sequence variations from dbSNP and Humsavar for TRIR Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000278000 -- 12,732,795(+) ACGTT(A/G)GCCAG intron-variant
rs1000389236 -- 12,733,966(+) GTCCA(C/G)ACTTA intron-variant
rs1000879915 -- 12,731,445(+) GACTG(A/C)AACGG intron-variant, nc-transcript-variant
rs1001663408 -- 12,735,402(+) CACTT(C/T)AGCCT upstream-variant-2KB
rs1001706220 -- 12,732,080(+) GGTTG(A/C)ACCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIR Gene

Variant ID Type Subtype PubMed ID
nsv953977 CNV deletion 24416366
nsv1160586 CNV duplication 26073780
dgv138n111 CNV deletion 26073780

Variation tolerance for TRIR Gene

Gene Damage Index Score: 0.11; 2.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIR Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIR Gene

Disorders for TRIR Gene

Relevant External Links for TRIR

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIR
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIR

No disorders were found for TRIR Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIR Gene

Publications for TRIR Gene

  1. Identification of an RNase that preferentially cleaves A/G nucleotides. (PMID: 28322335) Xie J … Guan W (Scientific reports 2017) 2 3 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. FIH Regulates Cellular Metabolism through Hydroxylation of the Deubiquitinase OTUB1. (PMID: 26752685) Scholz CC … Taylor CT (PLoS biology 2016) 3 60
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TRIR Gene

Sources for TRIR Gene

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