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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIQK Gene

protein-coding   GIFtS: 29
GCID: GC08M093896

Triple QxxK/R Motif Containing

(Previous name: chromosome 8 open reading frame 83)
(Previous symbol: C8orf83)
  Search for TRIQK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Triple QxxK/R Motif Containing1 2     PRO08452
C8orf831 2 3     UPF05992
Triple Repetitive-Sequence Of QXXK/R Protein Homolog2 3     Protein TRIQK2
Chromosome 8 Open Reading Frame 831     Triple QxxK/R Motif-Containing Protein2

External Ids:    HGNC: 278281   Entrez Gene: 2861442   Ensembl: ENSG000002051337   UniProtKB: Q629K13   

Export aliases for TRIQK gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIQK Gene: 
TRIQK (triple QxxK/R motif containing) is a protein-coding gene.

UniProtKB/Swiss-Prot: TRIQK_HUMAN, Q629K1
Function: May play a role in cell growth and maintenance of cell morphology (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NT_008046.16  NC_018919.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRIQK
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRIQK

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIQK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q22.1   Ensembl cytogenetic band:  8q22.1   HGNC cytogenetic band: 8q22.1

TRIQK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIQK gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08M093896:  view genomic region     (about GC identifiers)

Start:
93,895,758 bp from pter      End:
94,029,901 bp from pter
Size:
134,144 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIQK_HUMAN, Q629K1 (See protein sequence)
Recommended Name: Triple QxxK/R motif-containing protein  
Size: 86 amino acids; 9683 Da
Subcellular location: Endoplasmic reticulum membrane; Single-pass membrane protein

Explore the universe of human proteins at neXtProt for TRIQK: NX_Q629K1

Explore proteomics data for TRIQK at MOPED 

TRIQK Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRIQK Protein Expression

REFSEQ proteins (7 alternative transcripts): 
NP_001165266.1  NP_001165267.1  NP_001165268.1  NP_001165269.1  NP_001165270.1  NP_001177964.1  NP_001177965.1  

ENSEMBL proteins: 
 ENSP00000429517   ENSP00000430837   ENSP00000430915   ENSP00000429822   ENSP00000428822  
 ENSP00000428759   ENSP00000368138   ENSP00000427850   ENSP00000430992   ENSP00000428757  
 ENSP00000429742   ENSP00000429381   ENSP00000430683   ENSP00000430123   ENSP00000429302  
 ENSP00000442030  

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005789endoplasmic reticulum membrane IEA--
GO:0016021integral to membrane IEA--

TRIQK for ontologies           About GeneDecksing



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Cloud-Clone Corp. CLIAs for TRIQK


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR024842 TRIQK

Graphical View of Domain Structure for InterPro Entry Q629K1

ProtoNet protein and cluster: Q629K1

UniProtKB/Swiss-Prot: TRIQK_HUMAN, Q629K1
Similarity: Belongs to the TRIQK family


TRIQK for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: TRIQK_HUMAN, Q629K1
Function: May play a role in cell growth and maintenance of cell morphology (By similarity)

Animal Models:

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIQK

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIQK

Search CenterWatch for drugs/clinical trials and news about TRIQK

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIQK gene (7 alternative transcripts): 
NM_001171795.1  NM_001171796.1  NM_001171797.1  NM_001171798.1  NM_001171799.1  NM_001191035.1  NM_001191036.1  

Unigene Cluster for TRIQK:

Triple QxxK/R motif containing
Hs.440643  [show with all ESTs]
Unigene Representative Sequence: NM_001171796
18/23 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 23):
ENST00000521988(uc022axy.1 uc022axz.1 uc003yfn.4 uc003yfk.4 uc010map.3 uc003yfq.4 uc022aya.1 uc003yfr.4)
ENST00000518748 ENST00000523580 ENST00000520686 ENST00000520430 ENST00000517858
ENST00000517540 ENST00000378861 ENST00000524037 ENST00000521617 ENST00000518400
ENST00000520384 ENST00000519069 ENST00000524107 ENST00000519969 ENST00000517751
ENST00000522925 ENST00000522903
miRNA
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                     Customized lentivirus expression plasmids for stable overexpression of TRIQK 
Primer
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Additional mRNA sequence: 

AF130048.2 AK096398.1 AK097956.1 BC031029.1 BC065838.1 BC104254.1 BC104255.1 BC110326.1 
BC113007.1 BC113008.1 CR749421.1 DQ351291.1 

15 DOTS entries:

DT.444331  DT.100798569  DT.91746338  DT.99935818  DT.97842764  DT.121482459  DT.100798571  DT.91746337 
DT.100798568  DT.441957  DT.100718751  DT.121482465  DT.121482484  DT.91746332  DT.100798570 

24/191 AceView cDNA sequences (see all 191):

BM129142 BM558912 BU161234 AI611135 AI922444 BC065838 AI924905 CR606814 
CR603897 W04878 CN481393 AA242822 BQ574120 AI431851 BM993247 CA424893 
CN481345 CR598592 AF130048 BU683830 AA362987 AA236570 BU164707 BX338398 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


See TRIQK Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIQK

SOURCE GeneReport for Unigene cluster: Hs.440643
    SABiosciences Custom PCR Arrays for TRIQK
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIQK

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRIQK gene from 4/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Triqk5
Gm118181
predicted gene 118181, 5 90.31(n)1
88.37(a)1
  4 (5.58 cM)5
2088201  NM_001171801.11  NP_001165272.11 
 129068385 
chicken
(Gallus gallus)
Aves TRIQK1 triple QxxK/R motif containing 79.07(n)
79.07(a)
  771075  XM_001234376.1  XP_001234377.1 
lizard
(Anolis carolinensis)
Reptilia TRIQK6
Uncharacterized protein
74(a)
1 ↔ 1
4(18287597-18431350)
zebrafish
(Danio rerio)
Actinopterygii triqk1 triple QxxK/R motif containing 63.1(n)
66.67(a)
  100147776  NM_001127256.1  NP_001120728.1 


ENSEMBL Gene Tree for TRIQK (if available)
TreeFam Gene Tree for TRIQK (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1139 SNPs in TRIQK are shown (see all 1139)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 8 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2074695671,2
Cuntested193978456(+) GGTCCA/TGGACG 7 -- us2k10--------
rs1442229911,2
--93895260(+) AAGTGA/GTAGGA 7 -- int10--------
rs1925071061,2
--93895370(+) GTTATC/GGATGA 7 -- int10--------
rs1833434211,2
--93895430(+) CTGATA/GTATAG 7 -- int10--------
rs762163611,2
C,F--93895451(+) TCTACT/CGAATT 7 -- int11Minor allele frequency- C:0.06WA 118
rs1888053541,2
--93895673(+) TTAATC/GCTAGT 7 -- int10--------
rs100983601,2
C,F,H--93895676(+) ATGCTA/GGTTGT 7 -- int118Minor allele frequency- G:0.12NS EA NA WA 2342
rs1444239431,2
--93895680(+) TAGTTC/GTCTTG 7 -- int10--------
rs1899794311,2
--93895775(+) GTGATC/TTTTAA 7 -- ut310--------
rs1826204151,2
--93895858(+) AGGCAC/TCAACT 7 -- ut310--------

HapMap Linkage Disequilibrium report for TRIQK (93895758 - 94029901 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TRIQK: --
SABiosciences Cancer Mutation PCR Assays
SeqTarget long-range PCR primers for resequencing TRIQK
DNA2.0 Custom Variant and Variant Library Synthesis for TRIQK

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRIQK gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIQK)
    Utopia: connect your pdf to the dynamic
world of online information

  1. TRIQK, a novel family of small proteins localized to the endoplasmic reticulum membrane, is conserved across vertebrates. (PubMed id 18828657)1, 2, 3 Onuma Y....Whitman M. (2008)
  2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 286144 HGNC: 27828 AceView: LOC286144 Ensembl:ENSG00000205133 euGenes: HUgn286144
ECgene: TRIQK H-InvDB: TRIQK

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRIQK Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRIQK gene:
Search GeneIP for patents involving TRIQK

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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 Browse SwitchGear 3'UTR luciferase reporter plasmids for TRIQK
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 Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIQK
 inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIQK
 inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIQK
Customized:
 lentivirus for stable overexpression of TRIQK
 lentivirus expression plasmids for stable overexpression of TRIQK
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Customized transgenic rodents for:
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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(GIFtS: 73)
transforming growth factor, beta 1
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