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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIP6 Gene

protein-coding   GIFtS: 59
GCID: GC07P100464

thyroid hormone receptor interactor 6
 Explore 13 diseases affiliated with
TRIP6 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIP6    

Aliases
for TRIP6 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thyroid Hormone Receptor Interactor 61 2     MGC299591
OIP11 2 3 5     MGC38371
ZRP-11 2 3     MGC44231
Opa-Interacting Protein 12 3     TRIP6i22
OIP-12 3     Thyroid Hormone Receptor Interacting Protein 62
TRIP-62 3     Thyroid Receptor-Interacting Protein 62
TR-Interacting Protein 62 3     Zyxin Related Protein 12
MGC105561     Zyxin-Related Protein 13
MGC105581     

External Ids:    HGNC: 123111   Entrez Gene: 72052   Ensembl: ENSG000000870777   OMIM: 6029335   UniProtKB: Q156543   

Export aliases for TRIP6 gene to outside databases

Previous GC identifers: GC07U990119 GC07P098999 GC07P100062 GC07P100076 GC07P100109 GC07P100302 GC07P095095


Summaries
for TRIP6 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIP6:
This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein
localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane
occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively
spliced variants which encode different protein isoforms have been described; however, not all variants have been
fully characterized. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRIP6_HUMAN, Q15654
Function: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin
cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and
migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these
transcription factors induced by glucocorticoid receptor

Gene Wiki entry for TRIP6


Genomic Views
for TRIP6 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NC_018918.1  NT_007933.15  NT_079595.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIP6 gene promoter:
         c-Fos   STAT1   AP-1   ATF-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TRIP6 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIP6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q22

TRIP6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP6 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100464:  view genomic region     (about GC identifiers)

Start:
 100,464,760 bp from pter      End:
 100,471,076 bp from pter
Size:
 6,317 bases      Orientation:
 plus strand

1 alternative location:
Chr7+,CRA_TCAG 99,824,555-99,830,681     

Proteins
for TRIP6 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIP6_HUMAN, Q15654 (See protein sequence)
Recommended Name: Thyroid receptor-interacting protein 6  
Size: 476 amino acids; 50288 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid
hormone. Interacts with PTPN13. Interacts with SVIL isoform 2. Interacts with LPAR2 but not other LPA receptors.
Interacts with PRKAA2. Interacts with MAGI1. Interacts with SCRIB (By similarity). Binds to S.typhimurium protein sseI
Subcellular location: Cytoplasm, cytoskeleton. Cell junction, focal adhesion. Nucleus. Cytoplasm. Note=Shuttles between
nucleus and cytoplasm
Sequence caution: Sequence=AAC41740.1; Type=Frameshift; Positions=461;
2 PDB 3D structures from and Proteopedia for TRIP6:
1X61 (3D)        2DLO (3D)    
Secondary accessions: A4D2E7 O15170 O15275 Q9BTB2 Q9BUE5 Q9BXP3 Q9UNT4

Explore the universe of human proteins at neXtProt for TRIP6: NX_Q15654

Post-translational modifications:

  • Phosphorylation at Tyr-55 by SRC is required for enhancement of lysophosphatidic acid-induced cell migration. Tyr-55 is
    • dephosphorylated by PTPN131
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15654

    • TRIP6 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_003293.2  
    ENSEMBL proteins: 
     ENSP00000200457   ENSP00000413817   ENSP00000410736   ENSP00000389194  

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    Uscn Proteins for TRIP6

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005856cytoskeleton IEA--
    GO:0005925focal adhesion IDA14688263
    GO:0045323colocalizes with interleukin-1 receptor complex IDA15657077


    TRIP6 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TRIP6 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIP6 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR001781 Znf_LIM

    Graphical View of Domain Structure for InterPro Entry Q15654

    ProtoNet protein and cluster: Q15654

    1 Blocks protein family: IPB001781 Zn-binding protein

    UniProtKB/Swiss-Prot: TRIP6_HUMAN, Q15654
    Domain: The LIM zinc-binding domains mediate interaction with LPAR2 and with S.typhimurium protein sseI
    Similarity: Belongs to the zyxin/ajuba family
    Similarity: Contains 3 LIM zinc-binding domains


    Function
    for TRIP6 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRIP6_HUMAN, Q15654
    Function: Relays signals from the cell surface to the nucleus to weaken adherens junction and promote actin
    cytoskeleton reorganization and cell invasiveness. Involved in lysophosphatidic acid-induced cell adhesion and
    migration. Acts as a transcriptional coactivator for NF-kappa-B and JUN, and mediates the transrepression of these
    transcription factors induced by glucocorticoid receptor

         Genatlas biochemistry entry for TRIP6:
    thyroid receptor interacting protein 6,homolog to LPP and ZYX (see symbols)

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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005149interleukin-1 receptor binding IDA15657077
    GO:0005515protein binding IPI--
    GO:0008270zinc ion binding IEA--
    GO:0019900kinase binding IPI15657077
    GO:0046966thyroid hormone receptor binding NAS9598321


    TRIP6 for ontologies           About GeneDecksing



    Pathways & Interactions
    for TRIP6 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1LPA receptor mediated events
    		LPA receptor mediated events1.00
    2Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    		NOD-like receptor signaling pathway0.36

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for TRIP6 
        LPA receptor mediated events


    1         Kegg Pathway  (Kegg details for TRIP6):
        NOD-like receptor signaling pathway


    TRIP6 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIP6

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/105 Interacting proteins for TRIP6 (Q156541, 2, 3 ENSP000002004574) via UniProtKB, MINT, STRING, and/or I2D (see all 105)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PPP1R16AQ96I341, 2, 3, ENSP000002925394EBI-742327,EBI-710402 MINT-68029 I2D: score=5 STRING: ENSP00000292539
    GFI1BQ5VTD92, 3, ENSP000003447824MINT-2863851 MINT-2863832 I2D: score=3 STRING: ENSP00000344782
    VCLP182062, 3, ENSP000002119984MINT-68320 I2D: score=6 STRING: ENSP00000211998
    FAM46CQ5VWP22, 3, ENSP000003584584MINT-66429 I2D: score=5 STRING: ENSP00000358458
    HOXA1P496392, 3, ENSP000003432464MINT-68332 I2D: score=5 STRING: ENSP00000343246
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0008588release of cytoplasmic sequestered NF-kappaB IDA15657077
    GO:0030335positive regulation of cell migration IMP14688263
    GO:0048041focal adhesion assembly NAS14688263


    TRIP6 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIP6 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    TRIP6 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIP6
    1 Novoseek chemical compound relationship for TRIP6 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 16.7 6 10400701 (2), 15988003 (1), 17591779 (1)

    Search CenterWatch for drugs/clinical trials and news about TRIP6 

    Transcripts
    for TRIP6 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIP6 gene: 
    NM_003302.2  

    Unigene Cluster for TRIP6:

    Thyroid hormone receptor interactor 6
    Hs.534360  [show with all ESTs]
    Unigene Representative Sequence: AK093437
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200457(uc003uww.3 uc022ait.1 uc022aiu.1 uc010lhk.2 uc022aiv.1)
    ENST00000496260 ENST00000417475 ENST00000476870 ENST00000437505 ENST00000463125
    ENST00000429658 ENST00000488670

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIP6
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRIP6:
    hsa-miR-4310
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    Inhib. RNA
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    OriGene shRNA RFP: TRIP6
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    Clone
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP6

    Additional cDNA sequence: 

    AB628085.1 AB628086.1 AB628087.1 AB628088.1 AF000974.1 AF025437.1 AJ001902.1 AK093437.1 
    AK291906.1 AK309312.1 BC002680.2 BC004249.1 BC004999.1 BC021540.1 BC028985.1 L40374.1 

    19 DOTS entries:

    DT.449491  DT.91650049  DT.100831258  DT.102843081  DT.40124023  DT.95266696  DT.102843082  DT.102843083 
    DT.100831260  DT.95267489  DT.100831261  DT.95266700  DT.95266705  DT.100831255  DT.95266694  DT.100840488 
    DT.121068868  DT.91789529  DT.92336719 

    24/419 AceView cDNA sequences (see all 419):

    BQ020360 R24003 AK056773 BQ641405 CR614307 AA527163 AA350779 CR615794 
    CR624549 CR597445 BX399681 CB529225 BM789106 CR605367 AW272719 CR616514 
    C00441 BX378439 CA945119 CR622523 BM848020 BM971861 BF440012 AL550495 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP6 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11
    SP1:                                      -                             -                     
    SP2:              -                       -                             -                     
    SP3:                                      -     -     -                                       
    SP4:                                                                                          
    SP5:              -           -           -                                                   


    ECgene alternative splicing isoforms for TRIP6

    Expression
    for TRIP6 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIP6 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCGGGCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIP6 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalic Ventricular ZoneNeural Tube
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIP6 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIP6

    SOURCE GeneReport for Unigene cluster: Hs.534360

    UniProtKB/Swiss-Prot: TRIP6_HUMAN, Q15654
    Tissue specificity: Abundantly expressed in kidney, liver and lung. Lower levels in heart, placenta and pancreas.
    Expressed in colonic epithelial cells. Up-regulated in colonic tumors

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    In Situ
    Assay Products:     
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    Orthologs
    for TRIP6 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIP6 gene from 3/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC7926971 thyroid receptor-interacting protein 6-like 60.06(n)
    58.41(a)    		   792697  XM_001922796.2  XP_001922831.2 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Zyx6
    		 Zyxin
    		 24(a)
    		 1 → many
    		 4(1077991-1084936)
    worm
    (Caenorhabditis elegans)    		 Secernentea zyx-16
    		 ZYXin family member (zyx-1)
    		 17(a)
    		 1 → many
    		 II(13056744-13071460)


    ENSEMBL Gene Tree for TRIP6 (if available)
    TreeFam Gene Tree for TRIP6 (if available) 

    Paralogs
    for TRIP6 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIP6 gene
    LPP2  FBLIM12  AJUBA2  WTIP2  ZYX2  LIMD12  
    12 SIMAP similar genes for TRIP6 using alignment to 2 protein entries:     TRIP6_HUMAN (see all proteins):
    TRIP6i4    DKFZp686J22257    TRIP6i1    LIMS1    LHX6    LHx4
    LHX4    LIMS2    LIMD1    LHX8    FBLIM1    LPP

    TRIP6 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIP6 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/191 NCBI SNPs in TRIP6 are shown (see all 191)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 7 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs754929161,2
    		F,--95093306(+) TAAGGC/TGAACT 3 -- int1 ut311Minor allele frequency- T:0.09WA 118
    rs25715961,2
    		C,F,--95095100(+) GCTGAC/TTCAGG 1 -- int1 tfbs31Minor allele frequency- T:0.05NA 120
    rs737142051,2
    		C,--95095271(+) AAGAGG/TGGGTG 1 -- int12Minor allele frequency- T:0.26WA 120
    rs733966401,2
    		C,--95101373(+) CCTGAC/TATCCA 3 -- us2k11Minor allele frequency- T:0.50WA 2
    rs1123959471,2
    		F,--95101511(+) CAGTCG/ATTGTT 3 -- us2k12Minor allele frequency- A:0.50CSA 6
    rs731824531,2
    		--95101817(+) CCACCA/GCCCTT 3 -- us2k10--------
    rs1828057581,2
    		--100463028(+) AGAAGC/TCGGGA 1 -- us2k10--------
    rs1881269701,2
    		--100463207(+) TTGCCA/GTAAGA 1 -- us2k10--------
    rs1928743741,2
    		--100463250(+) CTGACA/GCACCT 1 -- us2k10--------
    rs1485980511,2
    		--100463265(+) GTCAGC/TGTGTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIP6 (100464760 - 100471076 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIP6
         1 CNV: 3692

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    Disorders / Diseases
    for TRIP6 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIP6 for disorders           About GeneDecksing

    OMIM gene information: 602933    OMIM disorders: --

    13 diseases for TRIP6:    About MalaCards
    thyroiditis    precocious puberty    mammary paget's disease    uterine fibroid
    lipoma    osteopetrosis    ptosis    measles
    breast cancer    ataxia    carcinoma    pancreatic cancer
    pancreatitis

    1 Novoseek disease relationship for TRIP6 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lipoma 48.1 2 10400701 (1), 9598321 (1)


    Export disorders for TRIP6 gene to outside databases

    Publications
    for TRIP6 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIP6 gene, integrated from 9 sources (see all 52):
    (articles sorted by number of sources associating them with TRIP6)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The human TRIP6 gene encodes a LIM domain protein and maps to chromosome 7q22, a region associated with tumorigenesis. (PubMed id 9598321)1, 2, 3, 9 Yi J. and Beckerle M.C. (1998)
    2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    3. TRIP6 enhances lysophosphatidic acid-induced cell migration by interacting with the lysophosphatidic acid 2 receptor. (PubMed id 14688263)1, 2, 9 Xu J.... Lin F.-T. (2004)
    4. The tumor suppressor Scrib selectively interacts with specific members of the zyxin family of proteins. (PubMed id 16137684)1, 2, 9 Petit M.M.R....Van de Ven W.J.M. (2005)
    5. ZRP-1, a zyxin-related protein, interacts with the second PDZ domain of the cytosolic protein tyrosine phosphatase hPTP1E. (PubMed id 10400701)1, 2, 9 Murthy K.K.... Banville D. (1999)
    6. TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness. (PubMed id 19017743)1, 2 Chastre E....Kotelevets L. (2009)
    7. TRIP6 transcriptional co-activator is a novel substrate of AMP-activated protein kinase. (PubMed id 16624523)1, 2 Solaz-Fuster M.C....Sanz P. (2006)
    8. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    9. A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-kappaB- regulated promoters. (PubMed id 15489293)1, 2 Kassel O....Herrlich P. (2004)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    External Searches for TRIP6 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing TRIP6 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7205 HGNC: 12311 AceView: TRIP6 Ensembl:ENSG00000087077 euGenes: HUgn7205
    ECgene: TRIP6 Kegg: 7205 H-InvDB: TRIP6

    Other Databases showing TRIP6 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIP6 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIP6 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIP6 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for TRIP6 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIP6 gene:
    Search GeneIP for patents involving TRIP6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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