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Aliases for TRIP4 Gene

Aliases for TRIP4 Gene

  • Thyroid Hormone Receptor Interactor 4 2 3
  • Thyroid Receptor-Interacting Protein 4 3 4
  • TR-Interacting Protein 4 3 4
  • TRIP-4 3 4
  • ASC-1 3 4
  • ASC1 3 6
  • Thyroid Receptor Interacting Protein 4 3
  • Activating Signal Cointegrator 1 3
  • Zinc Finger, C2HC5-Type 3
  • Zinc Finger 2
  • C2HC5-Type 2
  • HsT17391 3
  • ZC2HC5 3

External Ids for TRIP4 Gene

Summaries for TRIP4 Gene

GeneCards Summary for TRIP4 Gene

TRIP4 (Thyroid Hormone Receptor Interactor 4) is a Protein Coding gene. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot for TRIP4 Gene

  • Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347).

Gene Wiki entry for TRIP4 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP4 Gene

Genomics for TRIP4 Gene

Genomic Location for TRIP4 Gene

Start:
64,387,748 bp from pter
End:
64,455,303 bp from pter
Size:
67,556 bases
Orientation:
Plus strand

Genomic View for TRIP4 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIP4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP4 Gene

Regulatory Elements for TRIP4 Gene

Proteins for TRIP4 Gene

  • Protein details for TRIP4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15650-TRIP4_HUMAN
    Recommended name:
    Activating signal cointegrator 1
    Protein Accession:
    Q15650
    Secondary Accessions:
    • B2RAS0
    • Q96ED7
    • Q9UKH0

    Protein attributes for TRIP4 Gene

    Size:
    581 amino acids
    Molecular mass:
    66146 Da
    Quaternary structure:
    • Interacts with the thyroid hormone receptor/TR (via the ligand-binding domain); this interaction requires the presence of thyroid hormone (PubMed:10454579). Interacts with the androgen receptor/AR; in an androgen, testosterone and dihydrotestosterone-dependent manner (PubMed:12390891). Interacts with ESR1 (estrogen ligand-bound); competes with UFSP2 (PubMed:10454579, PubMed:25219498). Interacts with UFSP2; competes with ligand-bound ESR1 (PubMed:25219498). Interacts with DDRGK1 and UFL1; the interaction with DDRGK1 is direct (PubMed:25219498). Interacts with NCOA1 (PubMed:25219498). Interacts with EP300 (PubMed:25219498). Exists as a steady-state complex associated with ASCC1, ASCC2 and HELIC1 (PubMed:12077347). Interacts with NEK6 (PubMed:20873783).
    SequenceCaution:
    • Sequence=AAC41738.1; Type=Frameshift; Positions=391, 444, 476; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIP4 Gene

neXtProt entry for TRIP4 Gene

Proteomics data for TRIP4 Gene at MOPED

Post-translational modifications for TRIP4 Gene

  • Phosphorylated by NEK6.
  • Polyufmylated by the UFM1-conjugating system composed of the enzymes UBA5, UFC1 and UFL1. Deufmylated by the protease UFSP2. Ufmylation of TRIP4 is promoted by ligand-bound nuclear receptors that compete with UFSP2 for interaction with TRIP4. Nuclear receptors-induced ufmylation promotes the recruitment of additional transcriptional coactivators like EP300 and NCOA1 and therefore the assembly of a coactivator complex facilitating nuclear receptor-mediated transcription.
  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys245 and Lys367

Other Protein References for TRIP4 Gene

No data available for DME Specific Peptides for TRIP4 Gene

Domains for TRIP4 Gene

Protein Domains for TRIP4 Gene

UniProtKB/Swiss-Prot:

TRIP4_HUMAN
Domain:
  • The C4-type zinc finger mediates a competitive interaction with UFSP2 and ligand-bound nuclear receptors. It also mediates interaction with the transcriptional coactivators and the basal transcription machinery.:
    • Q15650
genes like me logo Genes that share domains with TRIP4: view

No data available for Gene Families for TRIP4 Gene

Function for TRIP4 Gene

Molecular function for TRIP4 Gene

UniProtKB/Swiss-Prot Function: Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF-kappa-B (PubMed:12077347).

Gene Ontology (GO) - Molecular Function for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 25219498
GO:0003713 transcription coactivator activity IMP 25219498
GO:0005515 protein binding IPI 25219498
GO:0008270 zinc ion binding IEA --
GO:0016922 ligand-dependent nuclear receptor binding IDA 10454579
genes like me logo Genes that share ontologies with TRIP4: view

Phenotypes for TRIP4 Gene

GenomeRNAi human phenotypes for TRIP4:
genes like me logo Genes that share phenotypes with TRIP4: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIP4 Gene

Localization for TRIP4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP4 Gene

Nucleus. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269 PubMed:10454579, ECO:0000269 PubMed:20873783}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP4 Gene COMPARTMENTS Subcellular localization image for TRIP4 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 3
endoplasmic reticulum 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 10454579
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 10454579
GO:0005815 microtubule organizing center IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with TRIP4: view

Pathways for TRIP4 Gene

SuperPathways for TRIP4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIP4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated --
GO:0006366 transcription from RNA polymerase II promoter TAS 7776974
GO:0030520 intracellular estrogen receptor signaling pathway IDA 25219498
GO:0045893 positive regulation of transcription, DNA-templated IMP 25219498
GO:1901998 toxin transport IEA --
genes like me logo Genes that share ontologies with TRIP4: view

No data available for Pathways by source for TRIP4 Gene

Transcripts for TRIP4 Gene

Unigene Clusters for TRIP4 Gene

Thyroid hormone receptor interactor 4:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP4 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a ·
SP1: - -
SP2: - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: -
SP6: - -
SP7: - - -
SP8: - -
SP9: - - - - -
SP10:
SP11:
SP12:

ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
SP1: - -
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRIP4 Gene

GeneLoc Exon Structure for
TRIP4
ECgene alternative splicing isoforms for
TRIP4

Expression for TRIP4 Gene

mRNA expression in normal human tissues for TRIP4 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP4 Gene

SOURCE GeneReport for Unigene cluster for TRIP4 Gene Hs.500340

genes like me logo Genes that share expressions with TRIP4: view

Orthologs for TRIP4 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP4 36
  • 99.66 (n)
  • 99.83 (a)
TRIP4 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP4 36
  • 90.06 (n)
  • 88.39 (a)
TRIP4 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP4 36
  • 91.34 (n)
  • 90.53 (a)
TRIP4 37
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip4 36
  • 88.76 (n)
  • 88.64 (a)
Trip4 16
Trip4 37
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP4 37
  • 71 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP4 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip4 36
  • 87.61 (n)
  • 88.64 (a)
chicken
(Gallus gallus)
Aves TRIP4 36
  • 68.75 (n)
  • 69.88 (a)
TRIP4 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP4 37
  • 62 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.8014 36
zebrafish
(Danio rerio)
Actinopterygii trip4 36
  • 63.47 (n)
  • 60.58 (a)
trip4 37
  • 60 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000554 36
  • 49.84 (n)
  • 45.37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11710 36
  • 49.84 (n)
  • 42.16 (a)
CG11710 37
  • 36 (a)
OneToOne
CG11710 38
  • 39 (a)
worm
(Caenorhabditis elegans)
Secernentea asc-1 36
  • 45.5 (n)
  • 36.22 (a)
asc-1 37
  • 31 (a)
OneToOne
asc-1 38
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1169 37
  • 43 (a)
OneToOne
Species with no ortholog for TRIP4:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP4 Gene

ENSEMBL:
Gene Tree for TRIP4 (if available)
TreeFam:
Gene Tree for TRIP4 (if available)

Paralogs for TRIP4 Gene

Pseudogenes.org Pseudogenes for TRIP4 Gene

genes like me logo Genes that share paralogs with TRIP4: view

No data available for Paralogs for TRIP4 Gene

Variants for TRIP4 Gene

Sequence variations from dbSNP and Humsavar for TRIP4 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs936689 -- 64,443,328(+) AAGAA(A/G)GAGGA intron-variant
rs1463596 -- 64,434,065(+) GAGTC(C/T)CTCTG intron-variant
rs1466527 -- 64,435,004(+) tgagc(C/G)cagga intron-variant
rs1515187 -- 64,412,063(-) TTTTT(A/T)AAAAA intron-variant
rs1567985 -- 64,393,008(+) ATGCA(A/G)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP4 Gene

Variant ID Type Subtype PubMed ID
nsv904306 CNV Loss 21882294
esv2749784 CNV Deletion 23290073

Relevant External Links for TRIP4 Gene

HapMap Linkage Disequilibrium report
TRIP4

Disorders for TRIP4 Gene

Relevant External Links for TRIP4

Human Genome Epidemiology (HuGE) Navigator
TRIP4
genes like me logo Genes that share disorders with TRIP4: view

No data available for UniProtKB/Swiss-Prot for TRIP4 Gene

Publications for TRIP4 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  2. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. (PMID: 10454579) Kim H.J. … Lee J.W. (Mol. Cell. Biol. 1999) 3 4
  3. Novel transcription coactivator complex containing activating signal cointegrator 1. (PMID: 12077347) Jung D.-J. … Lee Y.C. (Mol. Cell. Biol. 2002) 3 4
  4. Activating signal cointegrator 1 is highly expressed in murine testicular Leydig cells and enhances the ligand-dependent transactivation of androgen receptor. (PMID: 12390891) Lee Y.S. … Lee K. (Biol. Reprod. 2002) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRIP4 Gene

Sources for TRIP4 Gene

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