Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIP4 Gene

protein-coding   GIFtS: 53
GCID: GC15P064876

Thyroid Hormone Receptor Interactor 4

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Thyroid Hormone Receptor Interactor 41 2     ASC12
Thyroid Receptor-Interacting Protein 42 3     HsT173912
ASC-12 3     Activating Signal Cointegrator 12
TRIP-42 3     Thyroid Receptor Interacting Protein 42
TR-Interacting Protein 42 3     

External Ids:    HGNC: 123101   Entrez Gene: 93252   Ensembl: ENSG000001036717   OMIM: 6045015   UniProtKB: Q156503   

Export aliases for TRIP4 gene to outside databases

Previous GC identifers: GC15P060490 GC15P057839 GC15P062258 GC15P062395 GC15P062467 GC15P064683 GC15P041503 GC15P064768


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIP4 Gene: 
TRIP4 (thyroid hormone receptor interactor 4) is a protein-coding gene. Diseases associated with TRIP4 include thyroiditis, and conjunctivitis. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot: TRIP4_HUMAN, Q15650
Function: Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1
and may play an important role in establishing distinct coactivator complexes under different cellular
conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of
transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor
transactivation and in testicular function (By similarity)

Gene Wiki entry for TRIP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIP4 gene promoter:
         RORalpha1   Pbx1a   FOXO1a   c-Myb   IRF-1   FOXO1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP4 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIP4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1

TRIP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P064876:  view genomic region     (about GC identifiers)

Start:
64,679,947 bp from pter      End:
64,747,502 bp from pter
Size:
67,556 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIP4_HUMAN, Q15650 (See protein sequence)
Recommended Name: Activating signal cointegrator 1  
Size: 581 amino acids; 66146 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction
requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and
HELIC1. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and
dihydrotestosterone-dependent manner (By similarity). Interacts with NEK6
Subcellular location: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
Note=Cytoplasmic under conditions of serum deprivation. Co-localizes with NEK6 in the centrosome
1 PDB 3D structure from and Proteopedia for TRIP4:
2E5O (3D)    
Secondary accessions: B2RAS0 Q96ED7 Q9UKH0

Explore the universe of human proteins at neXtProt for TRIP4: NX_Q15650

Explore proteomics data for TRIP4 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated by NEK6
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q15650

  • TRIP4 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIP4 Protein Expression
    REFSEQ proteins: NP_057297.2  
    ENSEMBL proteins: 
     ENSP00000261884   ENSP00000452675   ENSP00000453106   ENSP00000453276   ENSP00000454558  
     ENSP00000452764  

    Human Recombinant Protein Products for TRIP4: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for TRIP4
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for TRIP4
    GenScript Custom Purified and Recombinant Proteins Services for TRIP4
    Novus Biologicals TRIP4 Protein
    Novus Biologicals TRIP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIP4 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--

    TRIP4 for ontologies           About GeneDecksing



    TRIP4 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TRIP4
    GenScript Custom Superior Antibodies Services for TRIP4
    Novus Biologicals TRIP4 Antibodies
    Abcam antibodies for TRIP4
    Cloud-Clone Corp. Antibodies for TRIP4 
    ThermoFisher Antibodies for TRIP4
    LSBio Antibodies in human, mouse, rat for TRIP4 

    Assay Products for TRIP4: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIP4
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIP4
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIP4 
    Cloud-Clone Corp. CLIAs for TRIP4


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR009349 Znf_C2HC5
     IPR015947 PUA-like_domain
     IPR007374 ASCH_domain

    Graphical View of Domain Structure for InterPro Entry Q15650

    ProtoNet protein and cluster: Q15650

    1 Blocks protein domain: IPB009349 Putative zinc finger


    TRIP4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIP4_HUMAN, Q15650
    Function: Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1
    and may play an important role in establishing distinct coactivator complexes under different cellular
    conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of
    transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor
    transactivation and in testicular function (By similarity)

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS7776974
    GO:0008270zinc ion binding IEA--
    GO:0016922ligand-dependent nuclear receptor binding IDA10454579
         
    TRIP4 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIP4:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIP4 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIP4

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIP4 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIP4 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIP4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIP4:
    hsa-miR-3658 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTRIP4 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP4

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIP4
    Sirion Biotech Customized adenovirus for overexpression of TRIP4

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for TRIP4 (see all 10)
    OriGene ORF clones in mouse, rat for TRIP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIP4 (NM_016213)
    Sino Biological Human cDNA Clone for TRIP4
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP4
    Sirion Biotech Customized lentivirus for stable overexpression of TRIP4 
                         Customized lentivirus expression plasmids for stable overexpression of TRIP4 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIP4
    Search LifeMap BioReagents cell lines for TRIP4
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP4


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/45 Interacting proteins for TRIP4 (Q156503 ENSP000002618844) via UniProtKB, MINT, STRING, and/or I2D (see all 45)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    ASCC3Q8N3C03, ENSP000003202524I2D: score=2 STRING: ENSP00000320252
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    NFKB1P198383, ENSP000002265744I2D: score=2 STRING: ENSP00000226574
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0045893positive regulation of transcription, DNA-dependent NAS10454579

    TRIP4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIP4

    Search CenterWatch for drugs/clinical trials and news about TRIP4

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIP4 gene: 
    NM_016213.4  

    Unigene Cluster for TRIP4:

    Thyroid hormone receptor interactor 4
    Hs.500340  [show with all ESTs]
    Unigene Representative Sequence: NM_016213
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559833 ENST00000559565 ENST00000261884(uc002anm.3) ENST00000557834
    ENST00000558820 ENST00000560567 ENST00000558442 ENST00000560920 ENST00000561265
    ENST00000560475 ENST00000558162 ENST00000559777
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIP4
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIP4:
    hsa-miR-3658 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTRIP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIP4
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP4
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIP4 (see all 10)
    OriGene ORF clones in mouse, rat for TRIP4
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIP4 (NM_016213)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP4
    Sirion Biotech Customized lentivirus for stable overexpression of TRIP4 
                         Customized lentivirus expression plasmids for stable overexpression of TRIP4 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIP4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIP4
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP4
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP4

    Additional mRNA sequence: 

    AK000433.1 AK314319.1 BC012448.1 L40371.1 

    14 DOTS entries:

    DT.92432677  DT.316109  DT.100787622  DT.100787621  DT.121022729  DT.121022764  DT.121022779  DT.92432682 
    DT.95295735  DT.97784733  DT.97842250  DT.100787623  DT.75189840  DT.40122721 

    24/180 AceView cDNA sequences (see all 180):

    AI243972 AK000433 AA631273 BI908371 BF941675 AW294281 BQ070841 AA150771 
    BQ637788 BQ690992 CB214991 AW192610 AL703335 CA425850 CR608924 BP345744 
    AA282728 BM907154 AW572576 CB216417 BE740238 BP364561 AA622172 BM831023 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a ·
    SP1:                                      -     -                                                                                                               
    SP2:                                      -     -     -                                                                                                         
    SP3:              -     -     -     -     -     -     -                                                                       -                                 
    SP4:              -     -     -     -     -     -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -           -                     
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for TRIP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCAGTCCC
    TRIP4 Expression
    About this image


    See TRIP4 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIP4

    SOURCE GeneReport for Unigene cluster: Hs.500340
        SABiosciences Expression via Pathway-Focused PCR Array including TRIP4: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIP4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP4
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIP4
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP4
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIP4 gene from 9/18 species (see all 18)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip41 , 5 thyroid hormone receptor interactor 41, 5 88.76(n)1
    88.64(a)1
      9 (35.55 cM)5
    564041  NM_019797.41  NP_062771.21 
     658311365 
    chicken
    (Gallus gallus)
    Aves TRIP41 thyroid hormone receptor interactor 4 69.17(n)
    70.75(a)
      415330  XM_413717.3  XP_413717.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIP46
    Uncharacterized protein
    62(a)
    1 ↔ 1
    GL343490.1(462502-505657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80142 Xenopus laevis transcribed sequence with weak similarity more 74.17(n)    48012398 
    zebrafish
    (Danio rerio)
    Actinopterygii trip41 thyroid hormone receptor interactor 4 63.42(n)
    60.36(a)
      568585  NM_001077575.2  NP_001071043.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117101 , 3 ligand-dependent nuclear receptor
    interactor3
    CG117101
    39(a)3
    49.06(n)1
    41.56(a)1
      19D13
    330441  NM_134549.31  NP_608393.11 
    worm
    (Caenorhabditis elegans)
    Secernentea asc-11 , 3 Protein ASC-11 30(a)3
    45.28(n)1
    35.58(a)1
      II(15035068-15044507)3
    1751591  NM_064699.31  NP_497100.11 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G476101 transcription regulator/ zinc ion binding protein 44.2(n)
    35.13(a)
      823915  NM_114629.3  NP_190345.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04131001 hypothetical protein   --   4347045  NM_001069696.1  NP_001063161.1 


    ENSEMBL Gene Tree for TRIP4 (if available)
    TreeFam Gene Tree for TRIP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIP4 gene

    TRIP4 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRIP4
    PGOHUM00000243794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1397 SNPs in TRIP4 are shown (see all 1397)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30577631,2
    C--44749322(+) ttttt-/TT/TTT
            
    gagac
    1 -- int1 trp31NA 2
    rs791351251,2
    F--64678050(+) TGAGAC/TACTCT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1446858131,2
    C--64678100(+) CCACC-/TTGA  
            
    TTGAG
    1 -- us2k10--------
    rs1831049901,2
    --64678455(+) AAAATA/CATCTG 1 -- us2k10--------
    rs1481882731,2
    --64678550(+) GGCCTC/TGCTCT 1 -- us2k10--------
    rs1411762791,2
    --64678662(+) CTACAG/TGCATG 1 -- us2k10--------
    rs1877487411,2
    --64678699(+) CATTTC/TTGTAG 1 -- us2k10--------
    rs727589431,2
    C,F--64678701(+) TTTTTG/ATAGAG 1 -- us2k12Minor allele frequency- A:0.08NA 122
    rs1913186031,2
    --64678792(+) GCTGGC/GATTAC 1 -- us2k10--------
    rs357274561,2
    C--64678818(+) GCCCA-/GT    
       
    /GTGT
    GTGTG
    1 -- us2k11CSA 2

    HapMap Linkage Disequilibrium report for TRIP4 (64679947 - 64747502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRIP4:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2749784CNV Deletion23290073
    nsv904306CNV Loss21882294

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIP4
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIP4

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 604501    OMIM disorders: --

    2 diseases for TRIP4:    About MalaCards
    thyroiditis    conjunctivitis


    TRIP4 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TRIP4 (1 document)

    Export disorders for TRIP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIP4 gene, integrated from 9 sources (see all 25):
    (articles sorted by number of sources associating them with TRIP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2 Jung D.-J.... Lee Y.C. (2002)
    5. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. (PubMed id 10454579)1, 2 Kim H.J....Lee J.W. (1999)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    8. Toward an understanding of the protein interaction net work of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (2011)
    9. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    10. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9325 HGNC: 12310 AceView: TRIP4 Ensembl:ENSG00000103671 euGenes: HUgn9325
    ECgene: TRIP4 H-InvDB: TRIP4

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIP4 gene:
    Search GeneIP for patents involving TRIP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for TRIP4  
     OriGene qPCR primer pairs and template standards for TRIP4   OriGene Protein Over-expression Lysate for TRIP4  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRIP4  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIP4   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRIP4   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIP4   OriGene Custom Protein Services for TRIP4  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIP4
     QIAGEN SeqTarget long-range PCR primers for resequencing TRIP4
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP4
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP4
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP4
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP4
     GenScript Custom Purified and Recombinant Proteins Services for TRIP4 GenScript cDNA clones with any tag delivered in your preferred vector for TRIP4
     GenScript Custom Assay Services for TRIP4 GenScript Custom Superior Antibodies Services for TRIP4
     GenScript Custom overexpressing Cell Line Services for TRIP4 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TRIP4 promoter
     Search Chromatin IP Primers for TRIP4
     RT2 qPCR Primer Assay in human, mouse, rat TRIP4
     Search GNC Networks for TRIP4
     SABiosciences PCR Arrays including human, mouse, rat TRIP4
     Search Tocris compounds for TRIP4
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     cDNA Clones for TRIP4
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TRIP4 antibodies
     TRIP4 proteins
     TRIP4 lysates
     Antibodies for TRIP4
     See all of Abcam's Antibodies, Kits and Proteins for TRIP4
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for TRIP4
     Antibodies for TRIP4
     ELISAs for TRIP4
     CLIAs for TRIP4
     Search LifeMap BioReagents cell lines for TRIP4
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP4
     SwitchGear 3'UTR luciferase reporter plasmids for TRIP4
     SwitchGear Promoter luciferase reporter plasmids for TRIP4
     ThermoFisher Antibodies for TRIP4
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP4
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIP4
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIP4
    Customized:
     lentivirus for stable overexpression of TRIP4
     lentivirus expression plasmids for stable overexpression of TRIP4
     adenovirus for overexpression of TRIP4
     LSBio Antibodies in human, mouse, rat for TRIP4
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIP4 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4