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TRIP4 Gene

protein-coding   GIFtS: 53
GCID: GC15P065758

Thyroid Hormone Receptor Interactor 4

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Interactor 41 2     Zinc Finger1
Thyroid Receptor-Interacting Protein 42 3     HsT173912
ASC-12 3     ZC2HC52
TRIP-42 3     Activating Signal Cointegrator 12
TR-Interacting Protein 42 3     Thyroid Receptor Interacting Protein 42
ASC12 5     Zinc Finger, C2HC5-Type2
C2HC5-type1     

External Ids:    HGNC: 123101   Entrez Gene: 93252   Ensembl: ENSG000001036717   OMIM: 6045015   UniProtKB: Q156503   

Export aliases for TRIP4 gene to outside databases

Previous GC identifers: GC15P060490 GC15P057839 GC15P062258 GC15P062395 GC15P062467 GC15P064683 GC15P041503 GC15P064768 GC15P064876


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIP4 Gene:
TRIP4 (thyroid hormone receptor interactor 4) is a protein-coding gene. GO annotations related to this gene include transcription coactivator activity and ligand-dependent nuclear receptor binding.

UniProtKB/Swiss-Prot: TRIP4_HUMAN, Q15650
Function: Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1
and may play an important role in establishing distinct coactivator complexes under different cellular
conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of
transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor
transactivation and in testicular function (By similarity)

Gene Wiki entry for TRIP4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIP4 gene promoter:
         RORalpha1   Pbx1a   FOXO1a   c-Myb   IRF-1   FOXO1   Evi-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP4 promoter sequence
   Search Chromatin IP Primers for TRIP4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIP4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1

TRIP4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP4 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P065758:  view genomic region     (about GC identifiers)

Start:
64,679,947 bp from pter      End:
64,747,502 bp from pter
Size:
67,556 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRIP4_HUMAN, Q15650 (See protein sequence)
Recommended Name: Activating signal cointegrator 1  
Size: 581 amino acids; 66146 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction
requires the presence of thyroid hormone. Exists as a steady-state complex associated with ASCC1, ASCC2 and
HELIC1. Interacts with the androgen receptor androgen (AR) in an androgen, testosterone and
dihydrotestosterone-dependent manner (By similarity). Interacts with NEK6
1 PDB 3D structure from and Proteopedia for TRIP4:
2E5O (3D)    
Secondary accessions: B2RAS0 Q96ED7 Q9UKH0

Explore the universe of human proteins at neXtProt for TRIP4: NX_Q15650

Explore proteomics data for TRIP4 at MOPED

Post-translational modifications: 

  • Phosphorylated by NEK61
  • Ubiquitination2 at Lys245, Lys367
  • Modification sites at PhosphoSitePlus

  • See TRIP4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_057297.2  
    ENSEMBL proteins: 
     ENSP00000261884   ENSP00000452675   ENSP00000453106   ENSP00000453276   ENSP00000454558  
     ENSP00000452764  

    TRIP4 Human Recombinant Protein Products:

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    Novus Biologicals TRIP4 Protein
    Novus Biologicals TRIP4 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIP4

     
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    Search eBioscience for ELISAs for TRIP4 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR007374 ASCH_domain
     IPR009349 Znf_C2HC5
     IPR015947 PUA-like_domain

    Graphical View of Domain Structure for InterPro Entry Q15650

    ProtoNet protein and cluster: Q15650

    1 Blocks protein domain: IPB009349 Putative zinc finger


    Find genes that share domains with TRIP4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIP4_HUMAN, Q15650
    Function: Transcription coactivator of nuclear receptors which functions in conjunction with CBP-p300 and SRC-1
    and may play an important role in establishing distinct coactivator complexes under different cellular
    conditions. Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of
    transrepression between nuclear receptor and either AP1 or NF-kappa-B. Plays a role in androgen receptor
    transactivation and in testicular function (By similarity)

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS7776974
    GO:0008270zinc ion binding IEA--
    GO:0016922ligand-dependent nuclear receptor binding IDA10454579
         
    Find genes that share ontologies with TRIP4           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIP4:
     Decreased Wnt reporter activit 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIP4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIP4
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIP4

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    2 qRT-PCR Assays for microRNAs that regulate TRIP4:
    hsa-miR-3658 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTRIP4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIP4

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    GenScript: all cDNA clones in your preferred vector: TRIP4 (NM_016213)
    Sino Biological Human cDNA Clone for TRIP4
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP4

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIP4_HUMAN, Q15650: Nucleus. Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Note=Cytoplasmic under conditions of serum deprivation. Colocalizes with NEK6 in the centrosome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3
    endoplasmic reticulum1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA10454579
    GO:0005815microtubule organizing center IEA--

    Find genes that share ontologies with TRIP4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TRIP4: 
              Nuclear Receptors & Coregulators in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIP4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIP4 (Q156503 ENSP000002618844) via UniProtKB, MINT, STRING, and/or I2D (see all 54)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RARAP102763, ENSP000002540664I2D: score=3 STRING: ENSP00000254066
    ASCC3Q8N3C03, ENSP000003202524I2D: score=2 STRING: ENSP00000320252
    JUNP054123, ENSP000003602664I2D: score=2 STRING: ENSP00000360266
    NFKB1P198383, ENSP000002265744I2D: score=2 STRING: ENSP00000226574
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0045893positive regulation of transcription, DNA-templated NAS10454579

    Find genes that share ontologies with TRIP4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIP4



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIP4 gene: 
    NM_016213.4  

    Unigene Cluster for TRIP4:

    Thyroid hormone receptor interactor 4
    Hs.500340  [show with all ESTs]
    Unigene Representative Sequence: NM_016213
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559833 ENST00000559565 ENST00000261884(uc002anm.3) ENST00000557834
    ENST00000558820 ENST00000560567 ENST00000558442 ENST00000560920 ENST00000561265
    ENST00000560475 ENST00000558162 ENST00000559777
    miRNA
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    2 qRT-PCR Assays for microRNAs that regulate TRIP4:
    hsa-miR-3658 hsa-miR-340
    SwitchGear 3'UTR luciferase reporter plasmidTRIP4 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIP4
    Predesigned siRNA for gene silencing in human, mouse, rat TRIP4
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIP4 (NM_016213)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP4
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP4
    Primer
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    OriGene qPCR primer pairs and template standards for TRIP4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIP4
      QuantiTect SYBR Green Assays in human, mouse, rat TRIP4
      QuantiFast Probe-based Assays in human, mouse, rat TRIP4

    Additional mRNA sequence: 

    AK000433.1 AK314319.1 BC012448.1 L40371.1 

    14 DOTS entries:

    DT.92432677  DT.316109  DT.100787622  DT.100787621  DT.121022729  DT.121022764  DT.121022779  DT.92432682 
    DT.95295735  DT.97784733  DT.97842250  DT.100787623  DT.75189840  DT.40122721 

    Selected AceView cDNA sequences (see all 180):

    CB122650 CB216417 AA622172 AA282728 BP364561 BF941675 AA468569 AW572576 
    BP346432 BE740238 BQ070841 BQ690992 AK000433 AW294281 AL703335 BI908371 
    BM831023 AW192610 AL544757 CR616759 CB214991 AI243972 BP345744 BM466513 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIP4 (see all 12)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9 ^ 10a · 10b · 10c ^ 11 ^ 12a ·
    SP1:                                      -     -                                                                                                               
    SP2:                                      -     -     -                                                                                                         
    SP3:              -     -     -     -     -     -     -                                                                       -                                 
    SP4:              -     -     -     -     -     -                                                                                                               
    SP5:                                            -                                                                                                               

    ExUns: 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b
    SP1:              -           -                     
    SP2:                                                
    SP3:                                                
    SP4:                                                
    SP5:                                                


    ECgene alternative splicing isoforms for TRIP4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIP4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACCAGTCCC
    TRIP4 Expression
    About this image

    TRIP4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIP4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.500340
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIP4: 
              Nuclear Receptors & Coregulators in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIP4
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP4
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIP4
    QuantiTect SYBR Green Assays in human, mouse, rat TRIP4
    QuantiFast Probe-based Assays in human, mouse, rat TRIP4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIP4 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip41 , 5 thyroid hormone receptor interactor 41, 5 88.76(n)1
    88.64(a)1
      9 (35.55 cM)5
    564041  NM_019797.41  NP_062771.21 
     658311365 
    chicken
    (Gallus gallus)
    Aves TRIP41 thyroid hormone receptor interactor 4 68.75(n)
    69.88(a)
      415330  XM_004943615.1  XP_004943672.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIP46
    thyroid hormone receptor interactor 4
    62(a)
    1 ↔ 1
    GL343490.1(462502-505657)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.80142 Xenopus laevis transcribed sequence with weak similarity more 74.17(n)    48012398 
    zebrafish
    (Danio rerio)
    Actinopterygii trip41 thyroid hormone receptor interactor 4 63.47(n)
    60.58(a)
      568585  NM_001077575.2  NP_001071043.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG117101 , 3 ligand-dependent nuclear receptor
    interactor3
    CG117101
    39(a)3
    49.84(n)1
    42.16(a)1
      19D13
    330441  NM_134549.31  NP_608393.11 
    worm
    (Caenorhabditis elegans)
    Secernentea asc-11 , 3 asc-11 30(a)3
    45.5(n)1
    36.22(a)1
      II(15035068-15044507)3
    1751591  NM_064699.41  NP_497100.11 


    ENSEMBL Gene Tree for TRIP4 (if available)
    TreeFam Gene Tree for TRIP4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIP4 gene

    Find genes that share paralogs with TRIP4           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for TRIP4
    PGOHUM00000243794


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIP4 (see all 1397)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs30577631,2
    C--44749322(+) ttttt-/TT/TTT
            
    gagac
    1 -- int1 trp31NA 2
    rs791351251,2
    F--64678050(+) TGAGAC/TACTCT 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs1446858131,2
    C--64678100(+) CCACC-/TTGA  
            
    TTGAG
    1 -- us2k10--------
    rs1831049901,2
    --64678455(+) AAAATA/CATCTG 1 -- us2k10--------
    rs1481882731,2
    --64678550(+) GGCCTC/TGCTCT 1 -- us2k10--------
    rs1411762791,2
    --64678662(+) CTACAG/TGCATG 1 -- us2k10--------
    rs1877487411,2
    --64678699(+) CATTTC/TTGTAG 1 -- us2k10--------
    rs727589431,2
    C,F--64678701(+) TTTTTG/ATAGAG 1 -- us2k12Minor allele frequency- A:0.08NA 122
    rs1913186031,2
    --64678792(+) GCTGGC/GATTAC 1 -- us2k10--------
    rs357274561,2
    C--64678818(+) GCCCA-/GT    
       
    /GTGT
    GTGTG
    1 -- us2k11CSA 2

    HapMap Linkage Disequilibrium report for TRIP4 (64679947 - 64747502 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRIP4:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2749784CNV Deletion23290073
    nsv904306CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIP4
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604501    OMIM disorders: --


    Find genes that share disorders with TRIP4           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TRIP4 (1 document)

    Export disorders for TRIP4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIP4 gene, integrated from 10 sources (see all 25):
    (articles sorted by number of sources associating them with TRIP4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    2. Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome. (PubMed id 20873783)1, 2 Vaz Meirelles G.... Kobarg J. (J. Proteome Res. 2010)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Novel transcription coactivator complex containing activating signal cointegrator 1. (PubMed id 12077347)1, 2 Jung D.-J.... Lee Y.C. (Mol. Cell. Biol. 2002)
    6. Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation. (PubMed id 10454579)1, 2 Kim H.J....Lee J.W. (Mol. Cell. Biol. 1999)
    7. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    8. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    9. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9325 HGNC: 12310 AceView: TRIP4 Ensembl:ENSG00000103671 euGenes: HUgn9325
    ECgene: TRIP4 H-InvDB: TRIP4

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIP4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRIP4 gene:
    Search GeneIP for patents involving TRIP4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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