Aliases for TRIP13 Gene
External Ids for TRIP13 Gene
Previous GeneCards Identifiers for TRIP13 Gene
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]
GeneCards Summary for TRIP13 Gene
TRIP13 (Thyroid Hormone Receptor Interactor 13) is a Protein Coding gene. Diseases associated with TRIP13 include Pontocerebellar Hypoplasia Type 2A and Pontocerebellar Hypoplasia Type 5. GO annotations related to this gene include identical protein binding and transcription cofactor activity.
UniProtKB/Swiss-Prot for TRIP13 Gene
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).