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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIP13 Gene

protein-coding   GIFtS: 51
GCID: GC05P000892

thyroid hormone receptor interactor 13
 Explore 4 diseases affiliated with
TRIP13 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIP13    

Aliases
for TRIP13 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Thyroid Hormone Receptor Interactor 131 2 3     HPV16 E1 Protein-Binding Protein2 3
16E1BP1 2     TR-Interacting Protein 132 3
Human Papillomavirus Type 16 E1 Protein-Binding Protein2 3     HPV16 E1 Protein Binding Protein2
Thyroid Receptor-Interacting Protein 132 3     Pachytene Checkpoint Protein 2 Homolog2
16E1-BP2 3     Thyroid Receptor Interacting Protein 132
TRIP-132 3     PCH23

External Ids:    HGNC: 123071   Entrez Gene: 93192   Ensembl: ENSG000000715397   OMIM: 6045075   UniProtKB: Q156453   

Export aliases for TRIP13 gene to outside databases

Previous GC identifers: GC05P001105 GC05P000973 GC05P000945 GC05P000946


Summaries
for TRIP13 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIP13:
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent
transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of
several that may play a role in early-stage non-small cell lung cancer. (provided by RefSeq, Oct 2009)

UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645
Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at
early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of
homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and
non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for
synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body
formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of
RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity)

Gene Wiki entry for TRIP13


Genomic Views
for TRIP13 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIP13 gene promoter:
         GR   GR-beta   Tal-1beta   GATA-1   MEF-2A   STAT3   aMEF-2   GR-alpha   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIP13 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIP13

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15

TRIP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP13 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P000892:  view genomic region     (about GC identifiers)

Start:
 892,758 bp from pter      End:
 919,472 bp from pter
Size:
 26,715 bases      Orientation:
 plus strand

Proteins
for TRIP13 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645 (See protein sequence)
Recommended Name: Pachytene checkpoint protein 2 homolog  
Size: 432 amino acids; 48551 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not
require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1
Sequence caution: Sequence=AAC41732.1; Type=Frameshift; Positions=1, 5;
Secondary accessions: C9K0T3 D3DTC0 O15324
Alternative splicing: 2 isoforms:  Q15645-1   Q15645-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIP13: NX_Q15645

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q15645

    • TRIP13 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159732.1  NP_004228.1  

    ENSEMBL proteins: 
     ENSP00000166345   ENSP00000427528  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TRIP13
    OriGene Custom Protein Services for TRIP13 
    GenScript Custom Purified and Recombinant Proteins Services for TRIP13
    Novus Biologicals TRIP13 Protein
    Novus Biologicals TRIP13 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIP13

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus TAS7776974


    TRIP13 for ontologies           About GeneDecksing



    TRIP13 Antibody Products: 
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    Uscn Antibodies for TRIP13
    ThermoFisher Antibodies for TRIP13

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    Uscn ELISAs and CLIAs for TRIP13

    Protein Domains /
    Families
    for TRIP13 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIP13 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR003959 ATPase_AAA_core
     IPR003960 ATPase_AAA_CS
     IPR003593 AAA+_ATPase
     IPR001270 Chaprnin_ClpA/B

    Graphical View of Domain Structure for InterPro Entry Q15645

    ProtoNet protein and cluster: Q15645

    UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645
    Similarity: Belongs to the AAA ATPase family. PCH2 subfamily


    Function
    for TRIP13 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645
    Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at
    early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of
    homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and
    non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for
    synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body
    formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of
    RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity)

    miRNA
    Products:            		miRTarBase miRNAs that target TRIP13:
    hsa-mir-155 (MIRT001491)

    OriGene 3'-UTR Clone (see all 2): TRIP13
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIP13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRIP13:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: TRIP13 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIP13 (see all 7)
    OriGene shRNA RFP: TRIP13
    OriGene siRNA: TRIP13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP13

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIP13

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP13 (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIP13 (NM_004237)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP13 

    Cell Line
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    Search LifeMap BioReagents cell lines for TRIP13

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP13

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003712transcription cofactor activity TAS7776974
    GO:0005515protein binding IPI19060904
    GO:0005524ATP binding NAS9223484
    GO:0017111nucleoside-triphosphatase activity IEA--
    GO:0042802identical protein binding IEA--


    TRIP13 for ontologies           About GeneDecksing


    Animal Models:
         7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trip13):
     cellular  endocrine/exocrine gland  growth/size  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  reproductive system 

    TRIP13 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRIP13 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIP13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/851 Interacting proteins for TRIP13 (Q156451, 2, 3 ENSP000001663454) via UniProtKB, MINT, STRING, and/or I2D (see all 851)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAD2L1BPQ150131, 2, 3, ENSP000004108184EBI-358993,EBI-712181 MINT-64187 MINT-66476 I2D: score=11 STRING: ENSP00000410818
    LASP1Q148471, 2, 3, ENSP000003252404EBI-358993,EBI-742828 MINT-66300 I2D: score=6 STRING: ENSP00000325240
    DDAH2O958651, 2, 3, ENSP000003649434EBI-358993,EBI-749139 MINT-67454 I2D: score=5 STRING: ENSP00000364943
    HDHD3Q9BSH51, 2, 3, ENSP000002383794EBI-358993,EBI-745201 MINT-66627 I2D: score=5 STRING: ENSP00000238379
    NIF3L1Q9GZT81, 2, 3, ENSP000003863944EBI-358993,EBI-740897 MINT-67889 I2D: score=5 STRING: ENSP00000386394
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000239pachytene IEA--
    GO:0001556oocyte maturation IEA--
    GO:0006302double-strand break repair ISS--
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0007130synaptonemal complex assembly ISS--


    TRIP13 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIP13 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIP13
    Search CenterWatch for drugs/clinical trials and news about TRIP13 / PCH2 

    Transcripts
    for TRIP13 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIP13 gene (2 alternative transcripts): 
    NM_001166260.1  NM_004237.3  

    Unigene Cluster for TRIP13:

    Thyroid hormone receptor interactor 13
    Hs.436187  [show with all ESTs]
    Unigene Representative Sequence: NM_004237
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000166345(uc003jbr.3) ENST00000512024(uc010ite.2) ENST00000508456
    ENST00000513435 ENST00000510412 ENST00000509210 ENST00000508430

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TRIP13
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIP13
    1 QIAGEN miScript miRNA Assays for microRNA that regulate TRIP13:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmid: TRIP13 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIP13 (see all 7)
    OriGene shRNA RFP: TRIP13
    OriGene siRNA: TRIP13
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP13
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP13 (see all 2)
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIP13 (NM_004237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP13 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIP13
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP13
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP13

    Additional cDNA sequence: 

    AK310376.1 BC000404.2 BC019294.1 CR456744.1 L40384.1 U96131.1 

    7 DOTS entries:

    DT.91772281  DT.415784  DT.97841788  DT.100698379  DT.95267852  DT.100754595  DT.91765850 

    24/151 AceView cDNA sequences (see all 151):

    BF001872 BM836153 AI274246 CA430053 AW160478 BC000404 AI222896 AA504500 
    AA456305 AA716100 BU619503 BQ065552 AI885478 BU151375 AI745513 AI383949 
    BE268193 BM790622 AW161027 AL526849 AI382344 AA134541 NM_004237 CR596381 

    GeneLoc Exon Structure


    Expression
    for TRIP13 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIP13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTACCTTACC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIP13 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    TestisSeminiferous TubulesPrimary SpermatocyteGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    PureStem™ progenitor F15 (Embryonic Progenitor Cell)

    See TRIP13 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIP13

    SOURCE GeneReport for Unigene cluster: Hs.436187
        SABiosciences Custom PCR Arrays for TRIP13
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP13

    Orthologs
    for TRIP13 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIP13 gene from 9/29 species (see all 29)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Trip131 , 5 thyroid hormone receptor interactor 131, 5 87.58(n)1
    93.29(a)1    		   13 (40.15 cM)5
    697161  NM_027182.21  NP_081458.11 
     739124625 
    chicken
    (Gallus gallus)    		 Aves TRIP131 thyroid hormone receptor interactor 13 74.9(n)
    84.15(a)    		   420798  XM_418892.3  XP_418892.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIP136
    		 --
    		 81(a)
    		 1 ↔ 1
    		 6(56050049-56072966)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.77272 Xenopus laevis transcribed sequence with moderate similarity more 75.68(n)    BX850628.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii zgc659522 hypothetical protein MGC65952 76.25(n)   393554  BC056713.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta pch21 CG31453-PA 53.33(n)
    47.44(a)    		   41013  NM_079558.4  NP_524282.4 
    worm
    (Caenorhabditis elegans)    		 Secernentea F10B5.53
    pch-21    		 ATP binding protein3
    Protein PCH-21    		 43(a)3
    49.1(n)1
    45.71(a)1    		   II(8158279-8159753)3
    1743131  NM_063310.51  NP_495711.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G247101 P-loop containing nucleoside triphosphate hydrolase-like more 53.18(n)
    53(a)    		   828573  NM_118604.4  NP_194202.3 
    rice
    (Oryza sativa)    		 Liliopsida Os04g04790001 hypothetical protein 55.59(n)
    54.97(a)    		   4336167  NM_001059626.1  NP_001053091.1 


    ENSEMBL Gene Tree for TRIP13 (if available)
    TreeFam Gene Tree for TRIP13 (if available) 

    Paralogs
    for TRIP13 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIP13 gene

    TRIP13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRIP13
    PGOHUM00000249134


    Genomic Variants
    for TRIP13 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/529 NCBI SNPs in TRIP13 are shown (see all 529)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1113722141,2
    		C,--882794(+) GCCCAG/CGGCTT 1 -- int11Minor allele frequency- C:0.50WA 2
    rs77348801,2
    		C--883004(+) ATTCAG/TTCAGT 1 -- int11Minor allele frequency- T:0.50NA 2
    rs77077901,2
    		C--883043(+) GCTCTA/GGCAGG 1 -- int10--------
    rs715933581,2
    		C--883067(+) TTCATG/TCAGTC 1 -- int11Minor allele frequency- T:0.50NA 2
    rs1434482971,2
    		--891113(+) CGGAGA/GAAACC 5 -- us2k1 int10--------
    rs1479941291,2
    		--891130(+) CAGAGA/GACACC 5 -- us2k1 int10--------
    rs77309351,2
    		C,F,A,H,--891440(+) AGGAGT/AAGGCG 5 -- us2k1 int18Minor allele frequency- A:0.09NS EA WA NA EU 1219
    rs1399026771,2
    		--891452(+) GATCCA/GGACAG 5 -- us2k1 int10--------
    rs771411661,2
    		F,--891485(+) TCTCAG/CGGGAG 5 -- us2k1 int11Minor allele frequency- C:0.08WA 118
    rs1836096251,2
    		--891731(+) CGTCCA/GGGCCA 5 -- us2k1 int10--------

    HapMap Linkage Disequilibrium report for TRIP13 (892758 - 919472 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for TRIP13
         8 CNVs: 68950 4429 8473 3537 32693 34515 23777 31218

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    Disorders / Diseases
    for TRIP13 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIP13 for disorders           About GeneDecksing

    OMIM gene information: 604507    OMIM disorders: --

    4 diseases for TRIP13:    About MalaCards
    thyroiditis    lung cancer    malaria    neuronitis


    Export disorders for TRIP13 gene to outside databases

    Publications
    for TRIP13 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIP13 gene, integrated from 9 sources (see all 34):
    (articles sorted by number of sources associating them with TRIP13)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. (PubMed id 9223484)1, 2 Yasugi T.... Benson J.D. (1997)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (2012)
    7. Host cell interactome of HIV-1 Rev includes RNA helica ses involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (2012)
    8. A high-throughput approach for measuring temporal chan ges in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (2012)
    9. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)
    10. Functional genomics identifies therapeutic targets for MYC-driven cancer. (PubMed id 22623531)1 Toyoshima M....Grandori C. (2012)

    External Searches for TRIP13 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIP13 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9319 HGNC: 12307 AceView: TRIP13 Ensembl:ENSG00000071539 euGenes: HUgn9319
    ECgene: TRIP13 H-InvDB: TRIP13

    Other Databases showing TRIP13 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TRIP13 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIP13 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIP13 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIP13 gene:
    Search GeneIP for patents involving TRIP13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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