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TRIP13 Gene

protein-coding   GIFtS: 52
GCID: GC05P000892

Thyroid Hormone Receptor Interactor 13

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Interactor 131 2 3     HPV16 E1 Protein-Binding Protein2 3
Thyroid Receptor Interacting Protein 131 2     TR-Interacting Protein 132 3
Human Papillomavirus Type 16 E1 Protein-Binding Protein2 3     16E1BP2
Thyroid Receptor-Interacting Protein 132 3     HPV16 E1 Protein Binding Protein2
16E1-BP2 3     Pachytene Checkpoint Protein 2 Homolog2
TRIP-132 3     PCH23

External Ids:    HGNC: 123071   Entrez Gene: 93192   Ensembl: ENSG000000715397   OMIM: 6045075   UniProtKB: Q156453   

Export aliases for TRIP13 gene to outside databases

Previous GC identifers: GC05P001105 GC05P000973 GC05P000945 GC05P000946


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIP13 Gene:
This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent
transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one
of several that may play a role in early-stage non-small cell lung cancer. (provided by RefSeq, Oct 2009)

GeneCards Summary for TRIP13 Gene:
TRIP13 (thyroid hormone receptor interactor 13) is a protein-coding gene. Diseases associated with TRIP13 include thyroiditis, and lung cancer. GO annotations related to this gene include nucleoside-triphosphatase activity and identical protein binding.

UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645
Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis.
Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient
completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both
crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and
is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes
and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream
of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By
similarity)

Gene Wiki entry for TRIP13 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_006576.17  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIP13 gene promoter:
         GR   GR-beta   Tal-1beta   GATA-1   MEF-2A   STAT3   aMEF-2   GR-alpha   ITF-2   ATF6   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP13 promoter sequence
   Search Chromatin IP Primers for TRIP13

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIP13


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.33   Ensembl cytogenetic band:  5p15.33   HGNC cytogenetic band: 5p15

TRIP13 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP13 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P000892:  view genomic region     (about GC identifiers)

Start:
892,758 bp from pter      End:
919,472 bp from pter
Size:
26,715 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645 (See protein sequence)
Recommended Name: Pachytene checkpoint protein 2 homolog  
Size: 432 amino acids; 48551 Da
Subunit: Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does
not require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1
Sequence caution: Sequence=AAC41732.1; Type=Frameshift; Positions=1, 5;
Secondary accessions: C9K0T3 D3DTC0 O15324
Alternative splicing: 2 isoforms:  Q15645-1   Q15645-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIP13: NX_Q15645

Explore proteomics data for TRIP13 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys185, Lys227, Lys288, Lys316
  • Modification sites at PhosphoSitePlus

  • See TRIP13 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001159732.1  NP_004228.1  

    ENSEMBL proteins: 
     ENSP00000166345   ENSP00000427528  

    TRIP13 Human Recombinant Protein Products:

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    Novus Biologicals TRIP13 Protein
    Novus Biologicals TRIP13 Lysate
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIP13

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    TRIP13 Assay Products:

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    Cloud-Clone Corp. CLIAs for TRIP13


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    AATP: ATPases / AAA-type

    5 InterPro protein domains:
     IPR003959 ATPase_AAA_core
     IPR001270 ClpA/B
     IPR003960 ATPase_AAA_CS
     IPR027417 P-loop_NTPase
     IPR003593 AAA+_ATPase

    Graphical View of Domain Structure for InterPro Entry Q15645

    ProtoNet protein and cluster: Q15645

    UniProtKB/Swiss-Prot: PCH2_HUMAN, Q15645
    Similarity: Belongs to the AAA ATPase family. PCH2 subfamily


    TRIP13 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: PCH2_HUMAN, Q15645
    Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis.
    Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient
    completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both
    crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and
    is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes
    and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream
    of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003712transcription cofactor activity TAS7776974
    GO:0005515protein binding IPI16169070
    GO:0005524ATP binding NAS9223484
    GO:0017111nucleoside-triphosphatase activity IEA--
         
    TRIP13 for ontologies           About GeneDecksing


    Phenotypes:
         7 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trip13):
     cellular  endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  limbs/digits/tail 
     mortality/aging  reproductive system 

    TRIP13 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIP13
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIP13

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIP13
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIP13

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIP13:
    hsa-mir-193b-3p (MIRT016349), hsa-mir-215-5p (MIRT024619), hsa-mir-192-5p (MIRT026520), hsa-mir-155-5p (MIRT001491)

    Block miRNA regulation of human, mouse, rat TRIP13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TRIP13:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidTRIP13 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIP13
    Predesigned siRNA for gene silencing in human, mouse, rat TRIP13

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for TRIP13 (see all 12)
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIP13 (NM_004237)
    Sino Biological Human cDNA Clone for TRIP13
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP13

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP13


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus4
    cytoskeleton3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001673male germ cell nucleus IEA--
    GO:0005634nucleus TAS7776974

    TRIP13 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIP13
    Interactions:

        Search GeneGlobe Interaction Network for TRIP13

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIP13 (Q156451, 2, 3 ENSP000001663454) via UniProtKB, MINT, STRING, and/or I2D (see all 938)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DDAH2O958651, 2, 3, ENSP000003649434EBI-358993,EBI-749139 MINT-67454 I2D: score=5 STRING: ENSP00000364943
    ENSG00000233076O958651, 2, 3, ENSP000004128004EBI-358993,EBI-749139 MINT-67454 I2D: score=5 STRING: ENSP00000412800
    ENSG00000206395O958651, 2, 3, ENSP000003729014EBI-358993,EBI-749139 MINT-67454 I2D: score=5 STRING: ENSP00000372901
    ENSG00000225635O958651, 2, 3EBI-358993,EBI-749139 MINT-67454 I2D: score=5 
    ENSG00000226634O958651, 2, 3EBI-358993,EBI-749139 MINT-67454 I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001556oocyte maturation IEA--
    GO:0006302double-strand break repair ISS--
    GO:0006366transcription from RNA polymerase II promoter TAS7776974
    GO:0007130synaptonemal complex assembly ISS--
    GO:0007131reciprocal meiotic recombination ISS--

    TRIP13 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIP13 (PCH2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIP13 gene (2 alternative transcripts): 
    NM_001166260.1  NM_004237.3  

    Unigene Cluster for TRIP13:

    Thyroid hormone receptor interactor 13
    Hs.436187  [show with all ESTs]
    Unigene Representative Sequence: NM_004237
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000166345(uc003jbr.3) ENST00000512024(uc010ite.2) ENST00000508456
    ENST00000513435 ENST00000510412 ENST00000509210 ENST00000508430
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIP13 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate TRIP13:
    hsa-miR-548p
    SwitchGear 3'UTR luciferase reporter plasmidTRIP13 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIP13
    Predesigned siRNA for gene silencing in human, mouse, rat TRIP13
    Clone
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    OriGene ORF clones in mouse, rat for TRIP13
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIP13 (NM_004237)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP13
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP13
    Primer
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    OriGene qPCR primer pairs and template standards for TRIP13
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP13
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIP13
      QuantiTect SYBR Green Assays in human, mouse, rat TRIP13
      QuantiFast Probe-based Assays in human, mouse, rat TRIP13

    Additional mRNA sequence: 

    AK310376.1 BC000404.2 BC019294.1 CR456744.1 L40384.1 U96131.1 

    7 DOTS entries:

    DT.91772281  DT.415784  DT.97841788  DT.100698379  DT.95267852  DT.100754595  DT.91765850 

    Selected AceView cDNA sequences (see all 151):

    BE268193 AI382344 BU857749 NM_004237 CA419984 AW161116 AI222896 CA426431 
    BE336907 AI383949 AA035686 CA423562 BU619589 BU164271 AA504500 BU151375 
    BC019294 BM995100 CA430053 BC000404 AA716100 AI274246 AA456305 AI745513 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIP13 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTACCTTACC
    TRIP13 Expression
    About this image


    TRIP13 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 8) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebral Cortex
     
     Thymus (Hematopoietic System)
             Thymus
     
     Gut Tube (Gastrointestinal Tract)
             Foregut
     
     Kidney (Urinary System)
             Metanephros
     
     Gonad
             Primary Spermatocyte Seminiferous Tubules
    TRIP13 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIP13 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436187
        Custom PCR Arrays for TRIP13
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP13

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIP13 gene from Selected species (see all 21)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip131 , 5 thyroid hormone receptor interactor 131, 5 87.58(n)1
    93.29(a)1
      13 (40.15 cM)5
    697161  NM_027182.21  NP_081458.11 
     739124625 
    chicken
    (Gallus gallus)
    Aves TRIP131 thyroid hormone receptor interactor 13 74.9(n)
    84.15(a)
      420798  XM_004935072.1  XP_004935129.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIP136
    thyroid hormone receptor interactor 13
    81(a)
    1 ↔ 1
    6(56050049-56072977)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.77272 Xenopus laevis transcribed sequence with moderate similarity more 75.68(n)    BX850628.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc659522 hypothetical protein MGC65952 76.25(n)   393554  BC056713.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta pch21 pch2 53.16(n)
    47.44(a)
      41013  NM_079558.4  NP_524282.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F10B5.53 ATP binding protein 43(a)   II(8158279-8159753)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes PCH2(YBR186W)4
    PCH21
    Nucleolar component of the pachytene checkpoint, which more4
    PCH21
    48.45(n)1
    39.4(a)1
      2(600553-602360)4
    8524841, 4  NP_009745.21, 4 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT4G247101 AT4G24710 54.05(n)
    53.52(a)
      828573  NM_118604.4  NP_194202.3 
    rice
    (Oryza sativa)
    Liliopsida Os04g04790001 Os04g0479000 55.59(n)
    54.97(a)
      4336167  NM_001059626.1  NP_001053091.1 


    ENSEMBL Gene Tree for TRIP13 (if available)
    TreeFam Gene Tree for TRIP13 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIP13 gene

    TRIP13 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TRIP13
    PGOHUM00000249134


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIP13 (see all 569)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18048651,2
    C--895053(+) TAAAGG/TTTAAA 4 V F mis11Minor allele frequency- T:0.00NA 2
    rs1996344571,2
    --895111(+) GAATA-/CAAAAG 2 -- int10--------
    rs668430011,2
    C--895112(+) AATAC-/AAAAGG 2 -- int13Minor allele frequency- A:0.00CSA 8
    rs1378807631,2
    --895198(+) TAGACA/CAGTTC 2 -- int10--------
    rs783744491,2
    F--895402(+) TGTGCT/CAGGAC 2 -- int12Minor allele frequency- C:0.04NA 122
    rs778210781,2
    C,F--895404(+) TGCTAG/AGACCA 2 -- int12Minor allele frequency- A:0.04NA 122
    rs1401745271,2
    C--895604(+) GGAAG-/AC    
       TTATC
    ACTTA
    2 -- int10--------
    rs343082871,2
    C--895609(+) ACTTA-/TC    
       ACTTA
    CAGCA
    2 -- int10--------
    rs1490383411,2
    --895673(+) ACTAAA/GTTCTG 2 -- int10--------
    rs584506091,2
    C,F--895682(+) TGCTCG/ATGAGG 2 -- int14Minor allele frequency- A:0.14WA CSA NA 242

    HapMap Linkage Disequilibrium report for TRIP13 (892758 - 919472 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRIP13 (see all 19):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1609077CNV Deletion17803354
    esv2729367CNV Deletion23290073
    esv2729369CNV Deletion23290073
    nsv821226CNV Deletion20802225
    esv2729366CNV Deletion23290073
    esv2729370CNV Deletion23290073
    esv2729368CNV Deletion23290073
    nsv509043CNV Insertion20534489
    nsv880898CNV Loss21882294
    nsv880383CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604507    OMIM disorders: --

    6 diseases for TRIP13:    
    About MalaCards
    thyroiditis    lung cancer    hiv-1    cerebritis
    malaria    neuronitis


    TRIP13 for disorders           About GeneDecksing


    Export disorders for TRIP13 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIP13 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with TRIP13)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. (PubMed id 9223484)1, 2 Yasugi T.... Benson J.D. (J. Virol. 1997)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Charting the landscape of tandem BRCT domain-mediated protein interactions. (PubMed id 22990118)1 Woods N.T....Monteiro A.N. (Sci Signal 2012)
    7. Host cell interactome of HIV-1 Rev includes RNA helicases involved in multiple facets of virus production. (PubMed id 22174317)1 Naji S....Gerace L. (amp 2012)
    8. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PubMed id 22223895)2 Bienvenut W.V....Giglione C. (amp 2012)
    9. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    10. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9319 HGNC: 12307 AceView: TRIP13 Ensembl:ENSG00000071539 euGenes: HUgn9319
    ECgene: TRIP13 H-InvDB: TRIP13

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIP13 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIP13 gene:
    Search GeneIP for patents involving TRIP13

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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