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Aliases for TRIP13 Gene

Aliases for TRIP13 Gene

  • Thyroid Hormone Receptor Interactor 13 2 3 4 5
  • Human Papillomavirus Type 16 E1 Protein-Binding Protein 3 4
  • Thyroid Receptor-Interacting Protein 13 3 4
  • TR-Interacting Protein 13 3 4
  • 16E1-BP 3 4
  • TRIP-13 3 4
  • Thyroid Receptor Interacting Protein 13 2
  • Pachytene Checkpoint Protein 2 Homolog 3
  • HPV16 E1 Protein Binding Protein 3
  • HPV16 E1 Protein-Binding Protein 4
  • 16E1BP 3
  • PCH2 4

External Ids for TRIP13 Gene

Previous GeneCards Identifiers for TRIP13 Gene

  • GC05P001105
  • GC05P000973
  • GC05P000945
  • GC05P000946

Summaries for TRIP13 Gene

Entrez Gene Summary for TRIP13 Gene

  • This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRIP13 Gene

TRIP13 (Thyroid Hormone Receptor Interactor 13) is a Protein Coding gene. Diseases associated with TRIP13 include Pontocerebellar Hypoplasia Type 2A and Pontocerebellar Hypoplasia Type 5. GO annotations related to this gene include identical protein binding and transcription cofactor activity.

UniProtKB/Swiss-Prot for TRIP13 Gene

  • Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Gene Wiki entry for TRIP13 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP13 Gene

Genomics for TRIP13 Gene

Regulatory Elements for TRIP13 Gene

Enhancers for TRIP13 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G001180 2 FANTOM5 Ensembl ENCODE dbSUPER 10 +291.3 291290 6.5 HDGF PKNOX1 MLX ARNT SIN3A ARID4B YBX1 YY1 ZNF766 KLF13 CTD-3080P12.3 SLC6A19 SLC6A18 SLC6A3 BRD9 TRIP13
GH05G001151 1.4 FANTOM5 ENCODE dbSUPER 10.1 +260.5 260470 2.6 PKNOX1 NFIB ZSCAN4 BMI1 THRB ZBTB7B GLIS2 ZNF207 RELB RCOR1 CTD-3080P12.3 SLC6A19 ENSG00000250173 SLC6A18 TERT TRIP13 BRD9 SLC6A3 ZDHHC11 SLC12A7
GH05G000656 1.2 ENCODE dbSUPER 11.3 -235.0 -234986 1.9 ATF1 ARNT TCF12 GATA2 FOS JUNB NCOA1 ZNF592 MBD2 SMARCA4 CEP72 TRIP13 BRD9 BRD9P2 ZDHHC11B ENSG00000250173 SLC9A3 PIR37264 LOC102724994
GH05G000849 1 Ensembl ENCODE 11.1 -42.6 -42649 0.8 TBP SAP130 ARID4B SIN3A DMAP1 RARA GATAD1 MAZ RFX1 HCFC1 BRD9 TRIP13 ZDHHC11B BRD9P2 ENSG00000250173 SLC9A3-AS1 ZDHHC11 LOC100653061
GH05G000663 0.8 dbSUPER 11.6 -227.0 -226967 4.9 KLF1 KLF17 MAX BMI1 ZIC2 RAD21 GLIS2 SCRT2 KLF8 SCRT1 CEP72 BRD9 TRIP13 BRD9P2 ZDHHC11B ENSG00000250173 ENSG00000271781 EXOC3-AS1 LOC101929895
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIP13 on UCSC Golden Path with GeneCards custom track

Promoters for TRIP13 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177474 57 1401 ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF143 ZNF207 KLF13 SP3

Genomic Location for TRIP13 Gene

Chromosome:
5
Start:
892,643 bp from pter
End:
919,357 bp from pter
Size:
26,715 bases
Orientation:
Plus strand

Genomic View for TRIP13 Gene

Genes around TRIP13 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP13 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP13 Gene

Proteins for TRIP13 Gene

  • Protein details for TRIP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15645-PCH2_HUMAN
    Recommended name:
    Pachytene checkpoint protein 2 homolog
    Protein Accession:
    Q15645
    Secondary Accessions:
    • C9K0T3
    • D3DTC0
    • O15324

    Protein attributes for TRIP13 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1.
    SequenceCaution:
    • Sequence=AAC41732.1; Type=Frameshift; Positions=1, 5; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIP13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP13 Gene

Post-translational modifications for TRIP13 Gene

  • Ubiquitination at isoforms=185, Lys227, posLast=288288, and isoforms=316
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIP13 Gene

No data available for DME Specific Peptides for TRIP13 Gene

Domains & Families for TRIP13 Gene

Gene Families for TRIP13 Gene

Protein Domains for TRIP13 Gene

Suggested Antigen Peptide Sequences for TRIP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15645

UniProtKB/Swiss-Prot:

PCH2_HUMAN :
  • Belongs to the AAA ATPase family. PCH2 subfamily.
Family:
  • Belongs to the AAA ATPase family. PCH2 subfamily.
genes like me logo Genes that share domains with TRIP13: view

Function for TRIP13 Gene

Molecular function for TRIP13 Gene

UniProtKB/Swiss-Prot Function:
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Gene Ontology (GO) - Molecular Function for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity TAS 7776974
GO:0005515 protein binding IPI 16169070
GO:0005524 ATP binding NAS,IEA 9223484
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with TRIP13: view
genes like me logo Genes that share phenotypes with TRIP13: view

Animal Models for TRIP13 Gene

MGI Knock Outs for TRIP13:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIP13 Gene

Localization for TRIP13 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIP13 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus TAS 7776974
genes like me logo Genes that share ontologies with TRIP13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIP13 Gene

Pathways & Interactions for TRIP13 Gene

SuperPathways for TRIP13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0006302 double-strand break repair IEA,ISS --
GO:0006366 transcription from RNA polymerase II promoter TAS 7776974
GO:0007130 synaptonemal complex assembly IEA,ISS --
GO:0007131 reciprocal meiotic recombination IEA,ISS --
genes like me logo Genes that share ontologies with TRIP13: view

No data available for Pathways by source and SIGNOR curated interactions for TRIP13 Gene

Drugs & Compounds for TRIP13 Gene

No Compound Related Data Available

Transcripts for TRIP13 Gene

Unigene Clusters for TRIP13 Gene

Thyroid hormone receptor interactor 13:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP13 Gene

No ASD Table

Relevant External Links for TRIP13 Gene

GeneLoc Exon Structure for
TRIP13
ECgene alternative splicing isoforms for
TRIP13

Expression for TRIP13 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIP13 Gene

This gene is overexpressed in Testis (x12.3).

Protein differential expression in normal tissues from HIPED for TRIP13 Gene

This gene is overexpressed in Bone (28.6), Testis (11.6), and Ovary (8.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIP13 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRIP13 Gene:

TRIP13

SOURCE GeneReport for Unigene cluster for TRIP13 Gene:

Hs.436187

Evidence on tissue expression from TISSUES for TRIP13 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with TRIP13: view

Primer Products

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIP13 Gene

Orthologs for TRIP13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRIP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP13 34 35
  • 99.23 (n)
dog
(Canis familiaris)
Mammalia TRIP13 34 35
  • 89.27 (n)
cow
(Bos Taurus)
Mammalia TRIP13 34 35
  • 88.66 (n)
mouse
(Mus musculus)
Mammalia Trip13 34 16 35
  • 87.58 (n)
rat
(Rattus norvegicus)
Mammalia Trip13 34
  • 87.35 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP13 35
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP13 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIP13 34 35
  • 74.9 (n)
lizard
(Anolis carolinensis)
Reptilia TRIP13 35
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trip13 34
  • 70.14 (n)
MGC76197 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.7727 34
zebrafish
(Danio rerio)
Actinopterygii trip13 34 35
  • 67.33 (n)
zgc65952 34
fruit fly
(Drosophila melanogaster)
Insecta pch2 34 35
  • 53.16 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001522 34
  • 49.83 (n)
worm
(Caenorhabditis elegans)
Secernentea F10B5.5 36
  • 43 (a)
pch-2 35
  • 37 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL258W 34
  • 49.76 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCH2 34 35 37
  • 48.45 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24710 34
  • 54.05 (n)
rice
(Oryza sativa)
Liliopsida Os04g0479000 34
  • 55.59 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5804 34
Species where no ortholog for TRIP13 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIP13 Gene

ENSEMBL:
Gene Tree for TRIP13 (if available)
TreeFam:
Gene Tree for TRIP13 (if available)

Paralogs for TRIP13 Gene

Pseudogenes.org Pseudogenes for TRIP13 Gene

genes like me logo Genes that share paralogs with TRIP13: view

No data available for Paralogs for TRIP13 Gene

Variants for TRIP13 Gene

Sequence variations from dbSNP and Humsavar for TRIP13 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000052388 -- 917,823(+) GTTTT(C/G)TTTGT intron-variant, utr-variant-3-prime
rs1000080687 -- 902,459(+) GGAAC(C/T)AGTTA intron-variant
rs1000099469 -- 892,611(+) CCTCG(C/T)AGGAC upstream-variant-2KB, reference, missense, utr-variant-5-prime
rs1000122459 -- 916,546(+) TGCTG(A/G)ACACA intron-variant
rs1000192567 -- 894,648(+) TTTGG(C/T)CCCAG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIP13 Gene

Variant ID Type Subtype PubMed ID
dgv198e55 CNV gain 17911159
esv1609077 CNV deletion 17803354
esv27211 CNV gain+loss 19812545
esv2729366 CNV deletion 23290073
esv2729367 CNV deletion 23290073
esv2729368 CNV deletion 23290073
esv2729369 CNV deletion 23290073
esv2729370 CNV deletion 23290073
esv2759316 CNV gain+loss 17122850
esv3569906 CNV loss 25503493
esv3569907 CNV loss 25503493
esv987824 CNV gain 20482838
nsv10654 CNV gain+loss 18304495
nsv1133013 OTHER inversion 24896259
nsv1147234 OTHER inversion 26484159
nsv428459 CNV gain+loss 18775914
nsv509043 CNV insertion 20534489
nsv596629 CNV gain 21841781
nsv821226 CNV deletion 20802225
nsv830186 CNV gain 17160897

Variation tolerance for TRIP13 Gene

Residual Variation Intolerance Score: 15.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.80; 16.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIP13 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP13 Gene

Disorders for TRIP13 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIP13 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pontocerebellar hypoplasia type 2a
  • pch2
pontocerebellar hypoplasia type 5
  • pontocerebellar hypoplasia, type 5
pontocerebellar hypoplasia, type 6
  • pontocerebellar hypoplasia type 6
mental retardation and microcephaly with pontine and cerebellar hypoplasia
  • syndromic x-linked intellectual disability najm type
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIP13

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIP13
genes like me logo Genes that share disorders with TRIP13: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIP13 Gene

Publications for TRIP13 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4 64
  2. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. (PMID: 9223484) Yasugi T. … Benson J.D. (J. Virol. 1997) 3 4 64
  5. Conformation-specific anti-Mad2 monoclonal antibodies for the dissection of checkpoint signaling. (PMID: 26986935) Sedgwick G.G. … Nilsson J. (MAbs 2016) 3 64

Products for TRIP13 Gene

Sources for TRIP13 Gene

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