Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIP13 Gene

Aliases for TRIP13 Gene

  • Thyroid Hormone Receptor Interactor 13 2 3 4
  • Human Papillomavirus Type 16 E1 Protein-Binding Protein 3 4
  • Thyroid Receptor Interacting Protein 13 2 3
  • Thyroid Receptor-Interacting Protein 13 3 4
  • HPV16 E1 Protein-Binding Protein 3 4
  • TR-Interacting Protein 13 3 4
  • 16E1-BP 3 4
  • TRIP-13 3 4
  • Pachytene Checkpoint Protein 2 Homolog 3
  • HPV16 E1 Protein Binding Protein 3
  • 16E1BP 3
  • PCH2 4

External Ids for TRIP13 Gene

Previous GeneCards Identifiers for TRIP13 Gene

  • GC05P001105
  • GC05P000973
  • GC05P000945
  • GC05P000946

Summaries for TRIP13 Gene

Entrez Gene Summary for TRIP13 Gene

  • This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung cancer. [provided by RefSeq, Oct 2009]

GeneCards Summary for TRIP13 Gene

TRIP13 (Thyroid Hormone Receptor Interactor 13) is a Protein Coding gene. Diseases associated with TRIP13 include lung cancer. GO annotations related to this gene include identical protein binding and nucleoside-triphosphatase activity.

UniProtKB/Swiss-Prot for TRIP13 Gene

  • Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Gene Wiki entry for TRIP13 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP13 Gene

Genomics for TRIP13 Gene

Regulatory Elements for TRIP13 Gene

Genomic Location for TRIP13 Gene

Start:
892,643 bp from pter
End:
919,357 bp from pter
Size:
26,715 bases
Orientation:
Plus strand

Genomic View for TRIP13 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIP13 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP13 Gene

Proteins for TRIP13 Gene

  • Protein details for TRIP13 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15645-PCH2_HUMAN
    Recommended name:
    Pachytene checkpoint protein 2 homolog
    Protein Accession:
    Q15645
    Secondary Accessions:
    • C9K0T3
    • D3DTC0
    • O15324

    Protein attributes for TRIP13 Gene

    Size:
    432 amino acids
    Molecular mass:
    48551 Da
    Quaternary structure:
    • Specifically interacts with the ligand binding domain of the thyroid receptor (TR). This interaction does not require the presence of thyroid hormone for its interaction. Interacts with HPV16 E1.
    SequenceCaution:
    • Sequence=AAC41732.1; Type=Frameshift; Positions=1, 5; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIP13 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP13 Gene

Proteomics data for TRIP13 Gene at MOPED

Post-translational modifications for TRIP13 Gene

  • Ubiquitination at Lys185, Lys227, Lys288, and Lys316
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIP13 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIP13 Gene

Domains for TRIP13 Gene

Gene Families for TRIP13 Gene

HGNC:
  • AATP :ATPases / AAA-type

Protein Domains for TRIP13 Gene

Suggested Antigen Peptide Sequences for TRIP13 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15645

UniProtKB/Swiss-Prot:

PCH2_HUMAN :
  • Q15645
Family:
  • Belongs to the AAA ATPase family. PCH2 subfamily.
genes like me logo Genes that share domains with TRIP13: view

Function for TRIP13 Gene

Molecular function for TRIP13 Gene

UniProtKB/Swiss-Prot Function: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes (By similarity).

Gene Ontology (GO) - Molecular Function for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003712 transcription cofactor activity TAS 7776974
GO:0005515 protein binding IPI 16169070
GO:0005524 ATP binding NAS 9223484
GO:0042802 identical protein binding IPI 16169070
genes like me logo Genes that share ontologies with TRIP13: view
genes like me logo Genes that share phenotypes with TRIP13: view

miRNA for TRIP13 Gene

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIP13 Gene

Localization for TRIP13 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP13 Gene COMPARTMENTS Subcellular localization image for TRIP13 gene
Compartment Confidence
nucleus 4
cytoskeleton 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001673 male germ cell nucleus IEA --
GO:0005634 nucleus TAS 7776974
genes like me logo Genes that share ontologies with TRIP13: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIP13 Gene

Pathways for TRIP13 Gene

SuperPathways for TRIP13 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIP13 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0006302 double-strand break repair ISS --
GO:0006366 transcription from RNA polymerase II promoter TAS 7776974
GO:0007130 synaptonemal complex assembly ISS --
GO:0007131 reciprocal meiotic recombination ISS --
genes like me logo Genes that share ontologies with TRIP13: view

No data available for Pathways by source for TRIP13 Gene

Transcripts for TRIP13 Gene

Unigene Clusters for TRIP13 Gene

Thyroid hormone receptor interactor 13:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP13 Gene

No ASD Table

Relevant External Links for TRIP13 Gene

GeneLoc Exon Structure for
TRIP13
ECgene alternative splicing isoforms for
TRIP13

Expression for TRIP13 Gene

mRNA expression in normal human tissues for TRIP13 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIP13 Gene

This gene is overexpressed in Testis (12.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP13 Gene

SOURCE GeneReport for Unigene cluster for TRIP13 Gene Hs.436187

genes like me logo Genes that share expressions with TRIP13: view

No data available for mRNA Expression by UniProt/SwissProt for TRIP13 Gene

Orthologs for TRIP13 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRIP13 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP13 35
  • 99.23 (n)
  • 99.54 (a)
TRIP13 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP13 35
  • 88.66 (n)
  • 93.98 (a)
TRIP13 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP13 35
  • 89.27 (n)
  • 93.29 (a)
TRIP13 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip13 35
  • 87.58 (n)
  • 93.29 (a)
Trip13 16
Trip13 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP13 36
  • 56 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP13 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip13 35
  • 87.35 (n)
  • 93.29 (a)
chicken
(Gallus gallus)
Aves TRIP13 35
  • 74.9 (n)
  • 84.15 (a)
TRIP13 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP13 36
  • 81 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7727 35
tropical clawed frog
(Silurana tropicalis)
Amphibia MGC76197 35
trip13 35
  • 70.14 (n)
  • 78.7 (a)
zebrafish
(Danio rerio)
Actinopterygii trip13 35
  • 67.33 (n)
  • 69.14 (a)
trip13 36
  • 66 (a)
OneToOne
zgc65952 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001522 35
  • 49.83 (n)
  • 45.48 (a)
fruit fly
(Drosophila melanogaster)
Insecta pch2 35
  • 53.16 (n)
  • 47.44 (a)
pch2 36
  • 40 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea pch-2 36
  • 37 (a)
OneToOne
F10B5.5 37
  • 43 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AEL258W 35
  • 49.76 (n)
  • 36.33 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes PCH2 35
  • 48.45 (n)
  • 39.4 (a)
PCH2 36
  • 23 (a)
OneToOne
PCH2 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G24710 35
  • 54.05 (n)
  • 53.52 (a)
rice
(Oryza sativa)
Liliopsida Os04g0479000 35
  • 55.59 (n)
  • 54.97 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5804 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
OneToOne
Species with no ortholog for TRIP13:
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIP13 Gene

ENSEMBL:
Gene Tree for TRIP13 (if available)
TreeFam:
Gene Tree for TRIP13 (if available)

Paralogs for TRIP13 Gene

Pseudogenes.org Pseudogenes for TRIP13 Gene

genes like me logo Genes that share paralogs with TRIP13: view

No data available for Paralogs for TRIP13 Gene

Variants for TRIP13 Gene

Sequence variations from dbSNP and Humsavar for TRIP13 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs11889 -- 917,144(+) GAACA(A/C)ACAAC utr-variant-3-prime
rs14389 -- 917,763(+) TGGAC(A/G)TCCCT utr-variant-3-prime
rs532981 -- 911,196(-) ATCAT(C/T)CCTAG intron-variant
rs532990 -- 911,189(-) CTAGA(C/T)ATACT intron-variant
rs546284 -- 900,341(+) AAAAA(G/T)TTGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP13 Gene

Variant ID Type Subtype PubMed ID
nsv881103 CNV Gain 21882294
dgv1736e1 CNV Complex 17122850
nsv428459 CNV Gain+Loss 18775914
nsv10654 CNV Gain+Loss 18304495
dgv198e55 CNV Gain 17911159
nsv880898 CNV Loss 21882294
nsv509043 CNV Insertion 20534489
nsv880488 CNV Gain 21882294
nsv830186 CNV Gain 17160897
esv27211 CNV Gain+Loss 19812545
nsv821226 CNV Deletion 20802225
esv987824 CNV Gain 20482838
esv2729366 CNV Deletion 23290073
esv1609077 CNV Deletion 17803354
esv2729367 CNV Deletion 23290073
esv2729368 CNV Deletion 23290073
esv2729369 CNV Deletion 23290073
esv2729370 CNV Deletion 23290073
nsv880383 CNV Gain 21882294

Relevant External Links for TRIP13 Gene

HapMap Linkage Disequilibrium report
TRIP13

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP13 Gene

Disorders for TRIP13 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIP13 Gene including...

Search for TRIP13 Gene in MalaCards »
genes like me logo Genes that share disorders with TRIP13: view

No data available for UniProtKB/Swiss-Prot for TRIP13 Gene

Publications for TRIP13 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  2. Two classes of human papillomavirus type 16 E1 mutants suggest pleiotropic conformational constraints affecting E1 multimerization, E2 interaction, and interaction with cellular proteins. (PMID: 9223484) Yasugi T. … Benson J.D. (J. Virol. 1997) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PMID: 15592455) Rush J. … Comb M.J. (Nat. Biotechnol. 2005) 3 4
  5. A human protein-protein interaction network: a resource for annotating the proteome. (PMID: 16169070) Stelzl U. … Wanker E.E. (Cell 2005) 3

Products for TRIP13 Gene

Sources for TRIP13 Gene

Back to Top

Content