TRIP12 Gene
protein-coding GIFtS: 60
GCID: GC02M230595
|
|
thyroid hormone receptor interactor 12
| |
Aliases
for TRIP12 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thyroid Hormone Receptor Interactor 121 2 | | TR-Interacting Protein 122 3 | | KIAA00451 3 | | E3 Ubiquitin-Protein Ligase TRIP122 | | Thyroid Receptor-Interacting Protein 122 3 | | Probable E3 Ubiquitin-Protein Ligase TRIP122 | | TRIP-122 3 | | Thyroid Receptor Interacting Protein 122 | | ULF2 3 | | EC 6.3.2.-3 | | E3 Ubiquitin-Protein Ligase For Arf2 3 | | |
Export aliases for TRIP12 gene to outside databasesPrevious GC identifers: GC02M228692 GC02M229363 GC02M230834 GC02M230457 GC02M230340 GC02M222471 |
Summaries
for TRIP12 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669Function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNArepair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein attheir N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediatesubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in differentcell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination ofisoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation.Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD orSMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damageresponse by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading ofubiquitinated chromatin at damaged chromosomes
Gene Wiki entry for TRIP12
|
Genomic Views
for TRIP12 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIP12 gene promoter:
E2F-4 E2F-3a E2F-5 Sox5 Nkx2-5 E2F-2 PPAR-gamma1 E2F E2F-1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIP12
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP12 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q36.3 Ensembl cytogenetic band: 2q36.3 HGNC cytogenetic band: 2q36.3TRIP12 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M230595: view genomic region
(about GC identifiers)
Start:
|
230,631,930 bp from pter |
End:
|
230,787,955 bp from pter |
Size:
|
156,026 bases |
Orientation:
|
minus strand |
|
Proteins
for TRIP12 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase TRIP12 Size: 1992 amino acids; 220434 Da
Subunit: Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD;leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disruptinteraction with SMARCE1
Subcellular location: Nucleus, nucleoplasm
Sequence caution: Sequence=AAY14681.1; Type=Erroneous gene model prediction; Sequence=AAY14755.1; Type=Erroneous genemodel prediction; Sequence=BAA05837.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D4HL82 Q14CA3 Q14CF1 Q15644 Q53R87 Q53TE7Alternative splicing: 4 isoforms: Q14669-1 Q14669-2 Q14669-3 Q14669-4 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TRIP12: NX_Q14669
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q14669
TRIP12 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004229.1
ENSEMBL proteins: ENSP00000283943 ENSP00000373697 ENSP00000373696 ENSP00000408330 ENSP00000386388 ENSP00000400967 ENSP00000409460 ENSP00000414385 ENSP00000389827 ENSP00000342442 ENSP00000440715 Reactome Protein details: Q14669
Human Recombinant Protein Products for TRIP12:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TRIP12 for ontologies About GeneDecksing
TRIP12 Antibody Products:
Assay Products for TRIP12: |
Protein
Domains /
Families
for TRIP12 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIP12 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q14669ProtoNet protein and cluster: Q14669 UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669Similarity: Belongs to the UPL family. K-HECT subfamilySimilarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domainSimilarity: Contains 1 WWE domain |
Function
for TRIP12 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TRIPC_HUMAN, Q14669Function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNArepair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein attheir N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediatesubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in differentcell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination ofisoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation.Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD orSMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damageresponse by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading ofubiquitinated chromatin at damaged chromosomes Enzyme Number (IUBMB): EC 6.3.2.-1
Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table
TRIP12 for ontologies About GeneDecksing
Phenotypes:
3 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Trip12):
TRIP12 for phenotypes About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIP12 (NM_004238) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIP12 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP12 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP12 |
|
Pathways & Interactions
for TRIP12 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Antigen processing: Ubiquitination & Proteasome degradation | | | 2 | Immune System | |
Pathway sources
See GeneCards unified pathways
Show all pathways
5 
Reactome Pathways for TRIP12
1 
Kegg Pathway (Kegg details for TRIP12):
UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669Pathway: Protein modification; protein ubiquitination
TRIP12 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIP12
STRING Interaction
Network Preview (showing 5 interactants - click image to see 20)
5/630 Interacting proteins for TRIP12 (Q146692, 3 ENSP000002839434) via UniProtKB, MINT, STRING, and/or I2D (see all 630)
About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
TRIP12 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIP12 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIP12
4 HMDB Compounds for TRIP12 About this table
Search CenterWatch for drugs/clinical trials and news about TRIP12 / TRIPC
|
Transcripts
for TRIP12 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIP12 gene: NM_004238.1 Unigene Cluster for TRIP12: Thyroid hormone receptor interactor 12 Hs.591633 [show with all ESTs]Unigene Representative Sequence: NM_00423818 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283943(uc021vxw.1 uc002vpw.1 uc002vpx.1 uc002vpy.1)
ENST00000389045 ENST00000389044(uc010zlz.1) ENST00000418123 ENST00000459841
ENST00000470302 ENST00000495322 ENST00000461189 ENST00000487178 ENST00000479037(uc010fxh.1)
ENST00000477441 ENST00000409677 ENST00000453485 ENST00000435716 ENST00000428959
ENST00000430954 ENST00000343290 ENST00000543084
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIP12 (NM_004238) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIP12 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP12 |
Additional cDNA sequence: AK124509.1 AK302468.1 AK310971.1 BC037956.1 BC113891.1 BC114556.1 D28476.1 EU489742.1 L40383.1 21 DOTS entries: DT.219031 DT.100033065 DT.100825090 DT.95364544 DT.121022468 DT.100825091 DT.101983147 DT.91888666 DT.95243132 DT.40247607 DT.303194 DT.92333466 DT.101957400 DT.108691 DT.121022534 DT.40132841 DT.65286528 DT.91747438 DT.97764576 DT.97767800 DT.40108373 24/425 AceView cDNA sequences (see all 425): BG291338 BQ690391 CA418222 BM979409 BQ186558 AW173523 BQ774766 AA678867 AI686370 CA398243 C00683 CB161648 BU509842 BM722108 D28476 AI804451 BX485712 AL043577 BU631360 AI276265 AI359781 D62612 AI140611 CN479998
GeneLoc Exon Structure
5/23 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP12 (see all 23) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | · | 9c | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17 | ^ | 18a | · | 18b | ^ | 19a | · | 19b | ^ | 20a | · |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 20b | · | 20c | ^ | 21a | · | 21b | ^ | 22a | · | 22b | ^ | 23 | ^ | 24 | ^ | 25a | · | 25b | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29a | · | 29b | ^ | 30a | · | 30b | · | 30c | ^ | 31a | · | 31b | ^ | 32 | ^ | 33a | · | 33b | ^ | 34a | · | 34b | · | 34c | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 35a | · | 35b | ^ | 36 | ^ | 37 | ^ | 38a | · | 38b | ^ | 39a | · | 39b | ^ | 40 | ^ | 41 | ^ | 42 | ^ | 43 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | - | | | | | | | | | |
ECgene alternative splicing isoforms for TRIP12
|
Expression
for TRIP12 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIP12 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTGCTGTG
About this image
See TRIP12 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIP12
SOURCE GeneReport for Unigene cluster: Hs.591633
SABiosciences Expression via Pathway-Focused PCR Array including TRIP12:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIP12
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIP12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP12 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP12 |
Orthologs
for TRIP12 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TRIP12 gene from 6/28 species (see all 28) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
TRIP121 |
thyroid hormone receptor interactor 12 |
85.5(n)
95.48(a) |
|
424785 XM_422603.2 XP_422603.2 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.129322 |
Xenopus laevis transcribed sequence with strong similarity more |
80.28(n) |
|
BU916166.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
Dr.164972 |
Transcribed sequence with moderate similarity to protein more |
76.99(n) |
|
BM036696.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG177353 |
ligand-dependent nuclear receptor
interactor |
55(a) |
|
-- |
thale cress
(Arabidopsis thaliana) |
eudicotyledons |
KAK1 |
E3 ubiquitin-protein ligase UPL3 |
44.67(n)
35.62(a) |
|
830017 NM_179236.2 NP_849567.2 |
rice
(Oryza sativa) |
Liliopsida |
Os.280662 |
Oryza sativa (japonica cultivar-group) cDNA clone0 more |
74.75(n) |
|
AK105706.1 |
ENSEMBL Gene Tree for TRIP12 (if available)
TreeFam Gene Tree for TRIP12 (if available) |
Paralogs
for TRIP12 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIP12 gene
- HECTD12
TRIP12 for paralogs About GeneDecksing
|
Genomic Variants
for TRIP12 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIP12 (230631930 - 230787955 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for TRIP12
4 CNVs: 79008 8396 90329 8395
Human Gene Mutation Database (HGMD): TRIP12
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIP12 |
|
Disorders
/ Diseases
for TRIP12 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIP12 for disorders About GeneDecksing
OMIM gene information: 604506
OMIM disorders: --
3  diseases for TRIP12: About MalaCardsthyroiditis dacryocystitis chronic dacryocystitis
1 disease from the University of Copenhagen DISEASES database for TRIP12:Chronic dacryocystitis Human Genome Epidemiology (HuGE) Navigator: TRIP12 (2 documents)
Export disorders for TRIP12 gene to outside databases
|
Publications
for TRIP12 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIP12 gene, integrated from 9 sources (see all 40):
(articles sorted by number of sources associating them with TRIP12) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
- TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes. (PubMed id 22884692)1, 2 Gudjonsson T.... Lukas C. (2012)
- TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. (PubMed id 22561347)1, 2 Chio I.I....Mak T.W. (2012)
- Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. (PubMed id 20208519)1, 2 Chen D....Gu W. (2010)
- Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex. (PubMed id 20829358)1, 2 Keppler B.R. and Archer T.K. (2010)
- The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. (PubMed id 19028681)1, 2 Park Y....Yoon J.B. (2009)
- TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. (PubMed id 18627766)1, 2 Park Y....Yoon J.B. (2008)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
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External Searches for TRIP12 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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Genome Databases showing TRIP12 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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Other Databases showing TRIP12 gene
(According to HUGE)
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Specialized Databases showing TRIP12 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TRIP12 | Pharmacogenomics, SNPs, Pathways |
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| Patent Information for TRIP12 gene:
Search GeneIP for patents involving TRIP12
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Products
for TRIP12 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIP12 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIP12 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIP12 | | OriGene 3'-UTR Clone for TRIP12 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP12 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIP12 | | OriGene Custom Protein Services for TRIP12 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIP12 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIP12 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP12 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIP12 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP12 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIP12 |
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| | | | Search Tocris compounds for TRIP12 |
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 | | | TRIP12 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP12 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TRIP12 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP12 |
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