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TRIP12 Gene

protein-coding   GIFtS: 63
GCID: GC02M230595

Thyroid Hormone Receptor Interactor 12

  See TRIP12-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Interactor 121 2     E3 Ubiquitin-Protein Ligase TRIP122
Thyroid Receptor-Interacting Protein 122 3     Probable E3 Ubiquitin-Protein Ligase TRIP122
TRIP-122 3     Thyroid Receptor Interacting Protein 122
ULF2 3     EC 6.3.2.-3
E3 Ubiquitin-Protein Ligase For Arf2 3     KIAA00453
TR-Interacting Protein 122 3     

External Ids:    HGNC: 123061   Entrez Gene: 93202   Ensembl: ENSG000001538277   OMIM: 6045065   UniProtKB: Q146693   

Export aliases for TRIP12 gene to outside databases

Previous GC identifers: GC02M228692 GC02M229363 GC02M230834 GC02M230457 GC02M230340 GC02M222471


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIP12 Gene:
TRIP12 (thyroid hormone receptor interactor 12) is a protein-coding gene. Diseases associated with TRIP12 include chronic dacryocystitis, and dacryocystitis. GO annotations related to this gene include ubiquitin-protein ligase activity and thyroid hormone receptor binding. An important paralog of this gene is HECTD1.

UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669
Function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA
repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein
at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates
ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for
p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located
in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate
ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to
their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins
such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key
regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that
promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard
against excessive spreading of ubiquitinated chromatin at damaged chromosomes

Gene Wiki entry for TRIP12 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIP12 gene promoter:
         E2F-4   E2F-3a   E2F-5   Sox5   Nkx2-5   E2F-2   PPAR-gamma1   E2F   E2F-1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP12 promoter sequence
   Search Chromatin IP Primers for TRIP12

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIP12


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q36.3   Ensembl cytogenetic band:  2q36.3   HGNC cytogenetic band: 2q36.3

TRIP12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP12 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M230595:  view genomic region     (about GC identifiers)

Start:
230,628,554 bp from pter      End:
230,787,955 bp from pter
Size:
159,402 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIP12  
Size: 1992 amino acids; 220434 Da
Subunit: Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with
TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to
disrupt interaction with SMARCE1
Sequence caution: Sequence=AAY14681.1; Type=Erroneous gene model prediction; Sequence=AAY14755.1; Type=Erroneous
gene model prediction; Sequence=BAA05837.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D4HL82 Q14CA3 Q14CF1 Q15644 Q53R87 Q53TE7
Alternative splicing: 4 isoforms:  Q14669-1   Q14669-2   Q14669-3   Q14669-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIP12: NX_Q14669

Explore proteomics data for TRIP12 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys259, Lys298, Lys355, Lys1038, Lys1048, Lys1221, Lys1259, Lys1288, Lys1600, Lys1661,
                                 Lys1668, Lys1941, Lys1977
  • Modification sites at PhosphoSitePlus

  • See TRIP12 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001271143.1  NP_001271144.1  NP_001271145.1  NP_004229.1  

    ENSEMBL proteins: 
     ENSP00000283943   ENSP00000373697   ENSP00000373696   ENSP00000408330   ENSP00000386388  
     ENSP00000400967   ENSP00000409460   ENSP00000414385   ENSP00000389827   ENSP00000342442  
     ENSP00000440715  
    Reactome Protein details: Q14669

    TRIP12 Human Recombinant Protein Products:

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    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIP12
    GenScript Custom Purified and Recombinant Proteins Services for TRIP12
    Novus Biologicals TRIP12 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIP12

     
    Search eBioscience for Proteins for TRIP12 

     
    antibodies-online proteins for TRIP12 (2 products) 

     
    Search antibodies-online for peptides for TRIP12

    TRIP12 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Novus Biologicals TRIP12 Antibody
    Abcam antibodies for TRIP12
    Cloud-Clone Corp. Antibodies for TRIP12
    Search ThermoFisher Antibodies for TRIP12
    antibodies-online antibodies for TRIP12 (4 products) 

    TRIP12 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIP12
    Cloud-Clone Corp. CLIAs for TRIP12
    Search eBioscience for ELISAs for TRIP12 
    antibodies-online kits for TRIP12 (2 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    4 InterPro protein domains:
     IPR011989 ARM-like
     IPR004170 WWE-dom
     IPR000569 HECT
     IPR016024 ARM-type_fold

    Graphical View of Domain Structure for InterPro Entry Q14669

    ProtoNet protein and cluster: Q14669

    UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669
    Similarity: Belongs to the UPL family. K-HECT subfamily
    Similarity: Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain
    Similarity: Contains 1 WWE domain


    Find genes that share domains with TRIP12           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIPC_HUMAN, Q14669
    Function: E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA
    repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein
    at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates
    ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for
    p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located
    in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate
    ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to
    their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins
    such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key
    regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that
    promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard
    against excessive spreading of ubiquitinated chromatin at damaged chromosomes

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IMP19028681
    GO:0005488binding ----
    GO:0005515protein binding IPI18627766
    GO:0008270zinc ion binding ----
    GO:0046966thyroid hormone receptor binding IDA7776974
         
    Find genes that share ontologies with TRIP12           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trip12):
     cellular  embryogenesis  growth/size/body  mortality/aging  normal 

    Find genes that share phenotypes with TRIP12           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRIP12

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIP12:
    hsa-mir-149-5p (MIRT045482), hsa-mir-124-3p (MIRT022779), hsa-mir-30a-5p (MIRT028570), hsa-let-7b-5p (MIRT032415), hsa-mir-18a-3p (MIRT040856), hsa-mir-193b-3p (MIRT041560), hsa-mir-106b-5p (MIRT044332), hsa-mir-92a-3p (MIRT049069), hsa-mir-615-3p (MIRT040237)

    Block miRNA regulation of human, mouse, rat TRIP12 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIP12 (see all 20):
    hsa-miR-188-5p hsa-miR-125a-3p hsa-miR-2909 hsa-miR-204 hsa-miR-548x hsa-miR-2276 hsa-miR-330-3p hsa-miR-3148
    SwitchGear 3'UTR luciferase reporter plasmidTRIP12 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIP12
    Predesigned siRNA for gene silencing in human, mouse, rat TRIP12

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIP12

    Clone
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    OriGene clones in human, mouse for TRIP12 (see all 6)
    OriGene ORF clones in mouse, rat for TRIP12
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    GenScript: all cDNA clones in your preferred vector: TRIP12 (NM_004238)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIP12
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP12

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP12


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIPC_HUMAN, Q14669: Nucleus, nucleoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    mitochondrion1
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IBA--
    GO:0005654nucleoplasm IDA--
    GO:0005737cytoplasm IBA--

    Find genes that share ontologies with TRIP12           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIP12 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    Ubiquitin mediated proteolysis0.35


    Find genes that share SuperPaths with TRIP12           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIP12
        Antigen processing: Ubiquitination & Proteasome degradation


    1 Kegg Pathway  (Kegg details for TRIP12):
        Ubiquitin mediated proteolysis

    UniProtKB/Swiss-Prot: TRIPC_HUMAN, Q14669
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIP12: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIP12

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIP12 (Q146692, 3 ENSP000002839434) via UniProtKB, MINT, STRING, and/or I2D (see all 714)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SMAD9O151982, 3, ENSP000003691544MINT-62070 I2D: score=3 STRING: ENSP00000369154
    ENSG00000258947Q135092, 3MINT-7945693 I2D: score=2 
    PSMC5P621952, 3, ENSP000003105724MINT-7945693 I2D: score=2 STRING: ENSP00000310572
    TUBB3Q135092, 3MINT-7945693 I2D: score=2 
    PSMC6P623332, 3, ENSP000004018024MINT-7945693 I2D: score=1 STRING: ENSP00000401802
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006281DNA repair IEA--
    GO:0006974cellular response to DNA damage stimulus IMP--
    GO:0009790embryo development ISS--
    GO:0016567protein ubiquitination ----
    GO:0042787protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP19028681

    Find genes that share ontologies with TRIP12           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIP12 (TRIPC)

    4 HMDB Compounds for TRIP12    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIP12 gene (4 alternative transcripts): 
    NM_001284214.1  NM_001284215.1  NM_001284216.1  NM_004238.2  

    Unigene Cluster for TRIP12:

    Thyroid hormone receptor interactor 12
    Hs.591633  [show with all ESTs]
    Unigene Representative Sequence: NM_004238
    18 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000283943(uc021vxw.1 uc002vpw.1 uc002vpx.1 uc002vpy.1)
    ENST00000389045 ENST00000389044(uc010zlz.1) ENST00000418123 ENST00000459841
    ENST00000470302 ENST00000495322 ENST00000461189 ENST00000487178 ENST00000479037(uc010fxh.1)
    ENST00000477441 ENST00000409677 ENST00000453485 ENST00000435716 ENST00000428959
    ENST00000430954 ENST00000343290 ENST00000543084
    miRNA
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    hsa-miR-188-5p hsa-miR-125a-3p hsa-miR-2909 hsa-miR-204 hsa-miR-548x hsa-miR-2276 hsa-miR-330-3p hsa-miR-3148
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIP12 (NM_004238)
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      QuantiTect SYBR Green Assays in human, mouse, rat TRIP12
      QuantiFast Probe-based Assays in human, mouse, rat TRIP12

    Additional mRNA sequence: 

    AK124509.1 AK302468.1 AK310971.1 BC037956.1 BC113891.1 BC114556.1 D28476.1 EU489742.1 
    L40383.1 

    21 DOTS entries:

    DT.219031  DT.100033065  DT.100825090  DT.95364544  DT.121022468  DT.100825091  DT.101983147  DT.91888666 
    DT.95243132  DT.40247607  DT.303194  DT.92333466  DT.101957400  DT.108691  DT.121022534  DT.40132841 
    DT.65286528  DT.91747438  DT.97764576  DT.97767800  DT.40108373 

    Selected AceView cDNA sequences (see all 425):

    BM979409 AA678867 BP339343 AI686370 C00683 BQ184590 D62612 AA079067 
    BQ774766 BG291338 AI359781 CN479998 AI276265 AA486804 AI370371 CB150366 
    BM725458 AA252102 AL042589 BQ025194 AI806079 BQ719978 BM998408 AA573132 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIP12 (see all 23)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b · 34c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                            -               
    SP3:                                                                                            -                                               -               
    SP4:                                                                                                                                            -               
    SP5:                                                                                                                                                            

    ExUns: 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43
    SP1:                                                                        
    SP2:                                                                        
    SP3:                                                                        
    SP4:                                                                        
    SP5:                                            -                           


    ECgene alternative splicing isoforms for TRIP12

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRIP12 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTGCTGTG
    TRIP12 Expression
    About this image


    TRIP12 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Thyroid (Endocrine System)
     
     Testis (Reproductive System)
    TRIP12 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIP12 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591633
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIP12: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIP12
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIP12
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP12

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for TRIP12 gene from Selected species (see all 20)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip121 , 5 thyroid hormone receptor interactor 121, 5 92.62(n)1
    98.29(a)1
      1 (43.42 cM)5
    148971  NM_133975.41  NP_598736.41 
     847211895 
    chicken
    (Gallus gallus)
    Aves TRIP121 thyroid hormone receptor interactor 12 85.47(n)
    95.53(a)
      424785  XM_004937064.1  XP_004937121.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIP126
    thyroid hormone receptor interactor 12
    89(a)
    1 ↔ 1
    3(22445564-22501647)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.129322 Xenopus laevis transcribed sequence with strong similarity more 80.28(n)    BU916166.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.164972 Transcribed sequence with moderate similarity to protein more 76.99(n)    BM036696.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG177353 ligand-dependent nuclear receptor
    interactor
    55(a)     --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes UFD4(YKL010C)4 Ubiquitin-protein ligase (E3) that interacts with Rpt4p more   --   11(425875-421424) 853859  NP_012915.1 
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons KAK1 KAK 46.94(n)
    39.44(a)
      830017  NM_179236.2  NP_849567.2 
    rice
    (Oryza sativa)
    Liliopsida Os.280662 Oryza sativa (japonica cultivar-group) cDNA clone0 more 74.75(n)    AK105706.1 


    ENSEMBL Gene Tree for TRIP12 (if available)
    TreeFam Gene Tree for TRIP12 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIP12 gene
    HECTD12  

    Find genes that share paralogs with TRIP12           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIP12 (see all 2921)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs681169731,2
    C--230124825(+) TTTTT-/T/TT  
            
    GAGAT
    1 -- int12NA 4
    rs574575311,2
    C--230136342(+) AAAAAA/-TGAGA 1 -- int12Minor allele frequency- -:0.25NA CSA 4
    rs118837071,2
    C,F,A,H--230631446(+) CTTAAC/TCTTCA 1 -- ds50017Minor allele frequency- T:0.05NS EA NA CSA WA 528
    rs1413591161,2
    --230631492(+) AGAGGA/CTGTTG 1 -- ds50010--------
    rs118895521,2
    C,F,H--230631513(+) TGCCAT/GGTAAA 1 -- ds50018Minor allele frequency- G:0.06NS EA WA NA CSA 520
    rs1910566211,2
    --230631574(+) TTAAAA/GCTAAA 1 -- ds50010--------
    rs1835687671,2
    --230631737(+) AAAAAA/CCTGTG 1 -- ds50010--------
    rs1887445591,2
    --230631820(+) AAACTA/GTATTT 1 -- ds50010--------
    rs1503677621,2
    --230631868(+) ACAAGA/TGTTGT 1 -- ds50010--------
    rs729873681,2
    C--230632087(+) GCCTGA/GTCACT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIP12 (230628554 - 230787955 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TRIP12:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv3200CNV Insertion18451855
    esv2751841CNV Gain17911159
    nsv460118CNV Gain19166990
    dgv164e55CNV Gain17911159

    Human Gene Mutation Database (HGMD): TRIP12
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIP12
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIP12

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604506    OMIM disorders: --

    2 diseases for TRIP12:    
    About MalaCards
    chronic dacryocystitis    dacryocystitis

    1 disease from the University of Copenhagen DISEASES database for TRIP12:
    Chronic dacryocystitis

    Find genes that share disorders with TRIP12           About GenesLikeMe

    Genetic Association Database (GAD): TRIP12
    Human Genome Epidemiology (HuGE) Navigator: TRIP12 (2 documents)

    Export disorders for TRIP12 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIP12 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with TRIP12)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    2. TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes. (PubMed id 22884692)1, 2 Gudjonsson T.... Lukas C. (Cell 2012)
    3. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. (PubMed id 22561347)1, 2 Chio I.I.... Mak T.W. (Nat. Cell Biol. 2012)
    4. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. (PubMed id 20208519)1, 2 Chen D.... Gu W. (Nature 2010)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. Ubiquitin-dependent and ubiquitin-independent control of subunit stoichiometry in the SWI/SNF complex. (PubMed id 20829358)1, 2 Keppler B.R. and Archer T.K. (J. Biol. Chem. 2010)
    7. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    8. The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. (PubMed id 19028681)1, 2 Park Y.... Yoon J.B. (J. Biol. Chem. 2009)
    9. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. (PubMed id 18627766)1, 2 Park Y.... Yoon J.B. (Biochem. Biophys. Res. Commun. 2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9320 HGNC: 12306 AceView: TRIP12 Ensembl:ENSG00000153827 euGenes: HUgn9320
    ECgene: TRIP12 Kegg: 9320 H-InvDB: TRIP12

    (According to HUGE)
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    HUGE: KIAA0045

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIP12 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRIP12 gene:
    Search GeneIP for patents involving TRIP12

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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