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Aliases for TRIP12 Gene

Aliases for TRIP12 Gene

  • Thyroid Hormone Receptor Interactor 12 2 3
  • Thyroid Receptor-Interacting Protein 12 3 4
  • E3 Ubiquitin-Protein Ligase For Arf 3 4
  • TR-Interacting Protein 12 3 4
  • TRIP-12 3 4
  • ULF 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIP12 3
  • Thyroid Receptor Interacting Protein 12 3
  • E3 Ubiquitin-Protein Ligase TRIP12 3
  • EC 6.3.2.- 4
  • KIAA0045 4

External Ids for TRIP12 Gene

Previous GeneCards Identifiers for TRIP12 Gene

  • GC02M228692
  • GC02M229363
  • GC02M230595
  • GC02M230834
  • GC02M230457
  • GC02M230340
  • GC02M222471

Summaries for TRIP12 Gene

GeneCards Summary for TRIP12 Gene

TRIP12 (Thyroid Hormone Receptor Interactor 12) is a Protein Coding gene. Diseases associated with TRIP12 include chronic dacryocystitis and dacryocystitis. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and thyroid hormone receptor binding. An important paralog of this gene is HECTD1.

UniProtKB/Swiss-Prot for TRIP12 Gene

  • E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Gene Wiki entry for TRIP12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP12 Gene

Genomics for TRIP12 Gene

Regulatory Elements for TRIP12 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIP12 Gene

Start:
229,763,837 bp from pter
End:
229,923,239 bp from pter
Size:
159,403 bases
Orientation:
Minus strand

Genomic View for TRIP12 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP12 Gene

Proteins for TRIP12 Gene

  • Protein details for TRIP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14669-TRIPC_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIP12
    Protein Accession:
    Q14669
    Secondary Accessions:
    • D4HL82
    • Q14CA3
    • Q14CF1
    • Q15644
    • Q53R87
    • Q53TE7

    Protein attributes for TRIP12 Gene

    Size:
    1992 amino acids
    Molecular mass:
    220434 Da
    Quaternary structure:
    • Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.
    SequenceCaution:
    • Sequence=AAY14681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAY14755.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA05837.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP12 Gene

Proteomics data for TRIP12 Gene at MOPED

Post-translational modifications for TRIP12 Gene

  • Ubiquitination at Lys259, Lys298, Lys355, Lys1038, Lys1048, Lys1221, Lys1259, Lys1288, Lys1600, Lys1661, Lys1668, Lys1941, and Lys1977
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIP12 Gene

Domains for TRIP12 Gene

Protein Domains for TRIP12 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIP12 Gene

Graphical View of Domain Structure for InterPro Entry

Q14669

UniProtKB/Swiss-Prot:

TRIPC_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Belongs to the UPL family. K-HECT subfamily.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 1 WWE domain.
Family:
  • Belongs to the UPL family. K-HECT subfamily.
genes like me logo Genes that share domains with TRIP12: view

No data available for Gene Families for TRIP12 Gene

Function for TRIP12 Gene

Molecular function for TRIP12 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Enzyme Numbers (IUBMB) for TRIP12 Gene

Gene Ontology (GO) - Molecular Function for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IMP 19028681
GO:0005488 binding --
GO:0005515 protein binding IPI 18627766
GO:0008270 zinc ion binding --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIP12: view
genes like me logo Genes that share phenotypes with TRIP12: view

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP12

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIP12 Gene

Localization for TRIP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP12 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP12 Gene COMPARTMENTS Subcellular localization image for TRIP12 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 21630459
GO:0005654 nucleoplasm IDA 20208519
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TRIP12: view

Pathways for TRIP12 Gene

genes like me logo Genes that share pathways with TRIP12: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q14669-TRIPC_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
GO:0006974 cellular response to DNA damage stimulus IMP 22884692
GO:0009790 embryo development ISS --
GO:0016567 protein ubiquitination --
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process IMP 19028681
genes like me logo Genes that share ontologies with TRIP12: view

Drugs for TRIP12 Gene

(4) HMDB Compounds for TRIP12 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-Adenosine monophosphate
61-19-8
Adenosine triphosphate
  • 5'-(Tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • Acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8
genes like me logo Genes that share compounds with TRIP12: view

Transcripts for TRIP12 Gene

Unigene Clusters for TRIP12 Gene

Thyroid hormone receptor interactor 12:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP12

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15: - - -
SP16: - -
SP17:
SP18:
SP19:
SP20: - - - - -
SP21: - - - -
SP22: - -
SP23:

ExUns: 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b · 34c ^
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for TRIP12 Gene

GeneLoc Exon Structure for
TRIP12
ECgene alternative splicing isoforms for
TRIP12

Expression for TRIP12 Gene

mRNA expression in normal human tissues for TRIP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for TRIP12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5) and Lymph node (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP12 Gene

SOURCE GeneReport for Unigene cluster for TRIP12 Gene Hs.591633

genes like me logo Genes that share expressions with TRIP12: view

Expression partners for TRIP12 Gene

* - Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIP12 Gene

Orthologs for TRIP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRIP12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIP12 35
  • 93.49 (n)
  • 98.34 (a)
TRIP12 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP12 35
  • 94.45 (n)
  • 98.94 (a)
TRIP12 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip12 35
  • 92.62 (n)
  • 98.29 (a)
Trip12 16
Trip12 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIP12 35
  • 99.7 (n)
  • 99.9 (a)
TRIP12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip12 35
  • 92.64 (n)
  • 98.51 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIP12 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRIP12 35
  • 85.47 (n)
  • 95.53 (a)
TRIP12 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP12 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9526 35
trip12 35
  • 79.19 (n)
  • 91.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12932 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16497 35
trip12 35
  • 72.97 (n)
  • 85.44 (a)
trip12 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10944 35
fruit fly
(Drosophila melanogaster)
Insecta CG17735 37
  • 55 (a)
ctrip 36
  • 15 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001296 35
  • 55.58 (n)
  • 57.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD4 36
  • 24 (a)
OneToMany
UFD4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons KAK 35
  • 46.94 (n)
  • 39.44 (a)
rice
(Oryza sativa)
Liliopsida Os.28066 35
Os02g0101700 35
  • 49.37 (n)
  • 43.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4507 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9340 36
  • 49 (a)
OneToOne
Species with no ortholog for TRIP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIP12 Gene

ENSEMBL:
Gene Tree for TRIP12 (if available)
TreeFam:
Gene Tree for TRIP12 (if available)

Paralogs for TRIP12 Gene

Paralogs for TRIP12 Gene

genes like me logo Genes that share paralogs with TRIP12: view

Variants for TRIP12 Gene

Sequence variations from dbSNP and Humsavar for TRIP12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs7600855 -- 229,886,995(+) TAACC(C/T)TAAGG intron-variant
rs7599184 -- 229,846,752(+) AATAA(C/G)ACAGA intron-variant
rs7598934 -- 229,807,459(+) gaaac(C/T)atgga intron-variant
rs7598508 -- 229,777,047(+) TAATA(C/T)GTCCA intron-variant
rs7598101 -- 229,886,862(+) GGTTA(C/T)GTGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP12 Gene

Variant ID Type Subtype PubMed ID
esv2751841 CNV Gain 17911159
dgv164e55 CNV Gain 17911159
nsv460118 CNV Gain 19166990
nsv3200 CNV Insertion 18451855

Relevant External Links for TRIP12 Gene

HapMap Linkage Disequilibrium report
TRIP12
Human Gene Mutation Database (HGMD)
TRIP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP12 Gene

Disorders for TRIP12 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRIP12 Gene in MalaCards »

(2) Diseases for TRIP12 Gene

(1) University of Copenhagen DISEASES for TRIP12 Gene

Relevant External Links for TRIP12

Genetic Association Database (GAD)
TRIP12
Human Genome Epidemiology (HuGE) Navigator
TRIP12
genes like me logo Genes that share disorders with TRIP12: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for TRIP12 Gene

Publications for TRIP12 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  3. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. (PMID: 18627766) Park Y. … Yoon J.B. (Biochem. Biophys. Res. Commun. 2008) 3 4
  4. The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. (PMID: 19028681) Park Y. … Yoon J.B. (J. Biol. Chem. 2009) 3 4
  5. TRADD contributes to tumour suppression by regulating ULF-dependent p19Arf ubiquitylation. (PMID: 22561347) Chio I.I. … Mak T.W. (Nat. Cell Biol. 2012) 3 4

Products for TRIP12 Gene

Sources for TRIP12 Gene

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