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Aliases for TRIP12 Gene

Aliases for TRIP12 Gene

  • Thyroid Hormone Receptor Interactor 12 2 3 5
  • Thyroid Receptor-Interacting Protein 12 3 4
  • E3 Ubiquitin-Protein Ligase For Arf 3 4
  • TR-Interacting Protein 12 3 4
  • TRIP-12 3 4
  • ULF 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIP12 3
  • Thyroid Receptor Interacting Protein 12 3
  • EC 6.3.2.- 4
  • KIAA0045 4

External Ids for TRIP12 Gene

Previous GeneCards Identifiers for TRIP12 Gene

  • GC02M228692
  • GC02M229363
  • GC02M230595
  • GC02M230834
  • GC02M230457
  • GC02M230340
  • GC02M222471

Summaries for TRIP12 Gene

GeneCards Summary for TRIP12 Gene

TRIP12 (Thyroid Hormone Receptor Interactor 12) is a Protein Coding gene. Diseases associated with TRIP12 include chronic dacryocystitis and chronic inflammation of lacrimal passage. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include binding and ubiquitin-protein transferase activity. An important paralog of this gene is HECTD1.

UniProtKB/Swiss-Prot for TRIP12 Gene

  • E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Gene Wiki entry for TRIP12 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP12 Gene

Genomics for TRIP12 Gene

Regulatory Elements for TRIP12 Gene

Enhancers for TRIP12 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIP12 on UCSC Golden Path with GeneCards custom track

Promoters for TRIP12 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIP12 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIP12 Gene

Chromosome:
2
Start:
229,763,837 bp from pter
End:
229,923,239 bp from pter
Size:
159,403 bases
Orientation:
Minus strand

Genomic View for TRIP12 Gene

Genes around TRIP12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP12 Gene

Proteins for TRIP12 Gene

  • Protein details for TRIP12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14669-TRIPC_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIP12
    Protein Accession:
    Q14669
    Secondary Accessions:
    • D4HL82
    • Q14CA3
    • Q14CF1
    • Q15644
    • Q53R87
    • Q53TE7

    Protein attributes for TRIP12 Gene

    Size:
    1992 amino acids
    Molecular mass:
    220434 Da
    Quaternary structure:
    • Interacts with MYC; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with TRADD; leading to disrupt interaction with isoform p19ARF/ARF of CDKN2A. Interacts with SMARCC1; leading to disrupt interaction with SMARCE1.
    SequenceCaution:
    • Sequence=AAY14681.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAY14755.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=BAA05837.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIP12 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP12 Gene

Proteomics data for TRIP12 Gene at MOPED

Post-translational modifications for TRIP12 Gene

  • Ubiquitination at Lys 259, Lys 298, Lys 355, Lys 1038, Lys 1048, Lys 1221, Lys 1259, Lys 1288, Lys 1600, Lys 1661, Lys 1668, and Lys 1941
  • Modification sites at PhosphoSitePlus

Antibody Products

No data available for DME Specific Peptides for TRIP12 Gene

Domains & Families for TRIP12 Gene

Protein Domains for TRIP12 Gene

Suggested Antigen Peptide Sequences for TRIP12 Gene

Graphical View of Domain Structure for InterPro Entry

Q14669

UniProtKB/Swiss-Prot:

TRIPC_HUMAN :
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Belongs to the UPL family. K-HECT subfamily.
Domain:
  • Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.
  • Contains 1 WWE domain.
Family:
  • Belongs to the UPL family. K-HECT subfamily.
genes like me logo Genes that share domains with TRIP12: view

No data available for Gene Families for TRIP12 Gene

Function for TRIP12 Gene

Molecular function for TRIP12 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardeless of the presence of lysine residues in target proteins. In normal cells, mediates ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A, a lysine-less tumor suppressor required for p53/TP53 activation under oncogenic stress. In cancer cells, however, isoform p19ARF/ARF and TRIP12 are located in different cell compartments, preventing isoform p19ARF/ARF ubiquitination and degradation. Does not mediate ubiquitination of isoform p16-INK4a of CDKN2A. Also catalyzes ubiquitination of NAE1 and SMARCE1, leading to their degradation. Ubiquitination and degradation of target proteins is regulated by interaction with proteins such as MYC, TRADD or SMARCC1, which disrupt the interaction between TRIP12 and target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of Lys-63-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.

Enzyme Numbers (IUBMB) for TRIP12 Gene

Gene Ontology (GO) - Molecular Function for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding IPI 18627766
GO:0016874 ligase activity IEA --
GO:0046966 thyroid hormone receptor binding IDA 7776974
genes like me logo Genes that share ontologies with TRIP12: view
genes like me logo Genes that share phenotypes with TRIP12: view

Animal Models for TRIP12 Gene

MGI Knock Outs for TRIP12:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIP12

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIP12 Gene

Localization for TRIP12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP12 Gene

Nucleus, nucleoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP12 Gene COMPARTMENTS Subcellular localization image for TRIP12 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
mitochondrion 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with TRIP12: view

Pathways & Interactions for TRIP12 Gene

genes like me logo Genes that share pathways with TRIP12: view

UniProtKB/Swiss-Prot Q14669-TRIPC_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIP12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0009790 embryo development IEA,ISS --
GO:0016567 protein ubiquitination IEA --
GO:1901315 negative regulation of histone H2A K63-linked ubiquitination IMP 22884692
GO:2000780 negative regulation of double-strand break repair IMP 22884692
genes like me logo Genes that share ontologies with TRIP12: view

No data available for SIGNOR curated interactions for TRIP12 Gene

Drugs & Compounds for TRIP12 Gene

(3) Drugs for TRIP12 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(1) Additional Compounds for TRIP12 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TRIP12: view

Transcripts for TRIP12 Gene

Unigene Clusters for TRIP12 Gene

Thyroid hormone receptor interactor 12:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP12 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19a · 19b ^ 20a ·
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -
SP10:
SP11:
SP12:
SP13:
SP14: - - -
SP15: - - -
SP16: - -
SP17:
SP18:
SP19:
SP20: - - - - -
SP21: - - - -
SP22: - -
SP23:

ExUns: 20b · 20c ^ 21a · 21b ^ 22a · 22b ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30a · 30b · 30c ^ 31a · 31b ^ 32 ^ 33a · 33b ^ 34a · 34b · 34c ^
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

ExUns: 35a · 35b ^ 36 ^ 37 ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42 ^ 43
SP1:
SP2:
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:
SP23:

Relevant External Links for TRIP12 Gene

GeneLoc Exon Structure for
TRIP12
ECgene alternative splicing isoforms for
TRIP12

Expression for TRIP12 Gene

mRNA expression in normal human tissues for TRIP12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIP12 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (23.5) and Lymph node (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP12 Gene



SOURCE GeneReport for Unigene cluster for TRIP12 Gene Hs.591633

genes like me logo Genes that share expression patterns with TRIP12: view

Protein tissue co-expression partners for TRIP12 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIP12 Gene

Orthologs for TRIP12 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TRIP12 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIP12 35
  • 93.49 (n)
  • 98.34 (a)
TRIP12 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP12 35
  • 94.45 (n)
  • 98.94 (a)
TRIP12 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip12 35
  • 92.62 (n)
  • 98.29 (a)
Trip12 16
Trip12 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIP12 35
  • 99.7 (n)
  • 99.9 (a)
TRIP12 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip12 35
  • 92.64 (n)
  • 98.51 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIP12 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 94 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
chicken
(Gallus gallus)
Aves TRIP12 35
  • 85.47 (n)
  • 95.53 (a)
TRIP12 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP12 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9526 35
trip12 35
  • 79.19 (n)
  • 91.1 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12932 35
zebrafish
(Danio rerio)
Actinopterygii Dr.16497 35
trip12 35
  • 72.97 (n)
  • 85.44 (a)
trip12 36
  • 79 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.10944 35
fruit fly
(Drosophila melanogaster)
Insecta CG17735 37
  • 55 (a)
ctrip 36
  • 15 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001296 35
  • 55.58 (n)
  • 57.47 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes UFD4 36
  • 24 (a)
OneToMany
UFD4 38
thale cress
(Arabidopsis thaliana)
eudicotyledons KAK 35
  • 46.94 (n)
  • 39.44 (a)
rice
(Oryza sativa)
Liliopsida Os.28066 35
Os02g0101700 35
  • 49.37 (n)
  • 43.04 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4507 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9340 36
  • 49 (a)
OneToOne
Species with no ortholog for TRIP12:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIP12 Gene

ENSEMBL:
Gene Tree for TRIP12 (if available)
TreeFam:
Gene Tree for TRIP12 (if available)

Paralogs for TRIP12 Gene

Paralogs for TRIP12 Gene

genes like me logo Genes that share paralogs with TRIP12: view

Variants for TRIP12 Gene

Sequence variations from dbSNP and Humsavar for TRIP12 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs475316 -- 229,904,475(+) CAATT(A/C)TGGTT intron-variant
rs475525 -- 229,869,365(+) ATACA(C/T)GCAAC intron-variant
rs476555 -- 229,854,165(+) TACAG(C/G)CATGA intron-variant
rs476827 -- 229,889,602(-) GAAAG(A/G)CTATT intron-variant
rs479492 -- 229,879,854(+) AGTAC(C/T)TGGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP12 Gene

Variant ID Type Subtype PubMed ID
esv2751841 CNV Gain 17911159
dgv164e55 CNV Gain 17911159
nsv460118 CNV Gain 19166990
nsv3200 CNV Insertion 18451855

Variation tolerance for TRIP12 Gene

Residual Variation Intolerance Score: 0.578% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.53; 29.69% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIP12 Gene

HapMap Linkage Disequilibrium report
TRIP12
Human Gene Mutation Database (HGMD)
TRIP12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP12 Gene

Disorders for TRIP12 Gene

MalaCards: The human disease database

(4) MalaCards diseases for TRIP12 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIP12

Genetic Association Database (GAD)
TRIP12
Human Genome Epidemiology (HuGE) Navigator
TRIP12
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIP12
genes like me logo Genes that share disorders with TRIP12: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIP12 Gene

Publications for TRIP12 Gene

  1. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4 67
  2. Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. (PMID: 26514267) Benleulmi-Chaachoua A. … Jockers R. (J. Pineal Res. 2016) 3
  3. Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF. (PMID: 24769896) Lo D. … Lu H. (Oncogene 2015) 3
  4. Proximity biotinylation and affinity purification are complementary approaches for the interactome mapping of chromatin-associated protein complexes. (PMID: 25281560) Lambert J.P. … Gingras A.C. (J Proteomics 2015) 3
  5. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X. … Chen J. (Mol. Syst. Biol. 2015) 3

Products for TRIP12 Gene

Sources for TRIP12 Gene

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