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Aliases for TRIP11 Gene

Aliases for TRIP11 Gene

  • Thyroid Hormone Receptor Interactor 11 2 3
  • TRIP230 3 4 6
  • CEV14 3 4 6
  • Clonal Evolution-Related Gene On Chromosome 14 Protein 3 4
  • Golgi-Associated Microtubule-Binding Protein 210 3 4
  • TR-Interacting Protein 11 3 4
  • GMAP-210 3 4
  • TRIP-11 3 4
  • ACG1A 3 6
  • Golgi-Microtubule-Associated Protein Of 210 KDa 3
  • Thyroid Receptor-Interacting Protein 11 3

External Ids for TRIP11 Gene

Previous GeneCards Identifiers for TRIP11 Gene

  • GC14M089942
  • GC14M086251
  • GC14M090423
  • GC14M090425
  • GC14M091505
  • GC14M092435
  • GC14M072615

Summaries for TRIP11 Gene

Entrez Gene Summary for TRIP11 Gene

  • This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

GeneCards Summary for TRIP11 Gene

TRIP11 (Thyroid Hormone Receptor Interactor 11) is a Protein Coding gene. Diseases associated with TRIP11 include achondrogenesis, type ia and achondrogenesis. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot for TRIP11 Gene

  • Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Gene Wiki entry for TRIP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP11 Gene

Genomics for TRIP11 Gene

Regulatory Elements for TRIP11 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIP11 Gene

Start:
91,965,991 bp from pter
End:
92,040,896 bp from pter
Size:
74,906 bases
Orientation:
Minus strand

Genomic View for TRIP11 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP11 Gene

Proteins for TRIP11 Gene

  • Protein details for TRIP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15643-TRIPB_HUMAN
    Recommended name:
    Thyroid receptor-interacting protein 11
    Protein Accession:
    Q15643
    Secondary Accessions:
    • B2RUT2
    • O14689
    • O15154
    • O95949

    Protein attributes for TRIP11 Gene

    Size:
    1979 amino acids
    Molecular mass:
    227586 Da
    Quaternary structure:
    • Binds RB1
    SequenceCaution:
    • Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955; Evidence={ECO:0000305};

neXtProt entry for TRIP11 Gene

Proteomics data for TRIP11 Gene at MOPED

Post-translational modifications for TRIP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIP11 Gene

No data available for DME Specific Peptides for TRIP11 Gene

Domains for TRIP11 Gene

Protein Domains for TRIP11 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TRIP11 Gene

Graphical View of Domain Structure for InterPro Entry

Q15643

UniProtKB/Swiss-Prot:

TRIPB_HUMAN :
  • Q15643
Domain:
  • Extended rod-like protein with coiled-coil domains
  • Contains 1 GRIP domain.
genes like me logo Genes that share domains with TRIP11: view

No data available for Gene Families for TRIP11 Gene

Function for TRIP11 Gene

Molecular function for TRIP11 Gene

GENATLAS Biochemistry: thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastoma protein
UniProtKB/Swiss-Prot Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Gene Ontology (GO) - Molecular Function for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9256431
GO:0003735 structural constituent of ribosome --
GO:0005515 protein binding IPI 17438371
genes like me logo Genes that share ontologies with TRIP11: view
genes like me logo Genes that share phenotypes with TRIP11: view

Animal Model Products

CRISPR Products

miRNA for TRIP11 Gene

miRTarBase miRNAs that target TRIP11

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP11

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIP11 Gene

Localization for TRIP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP11 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP11 Gene COMPARTMENTS Subcellular localization image for TRIP11 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002079 inner acrosomal membrane IEA --
GO:0002080 acrosomal membrane --
GO:0002081 outer acrosomal membrane IEA --
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with TRIP11: view

Pathways for TRIP11 Gene

SuperPathways for TRIP11 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000042 protein targeting to Golgi IEA --
GO:0003281 ventricular septum development IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9256431
GO:0006412 translation --
GO:0006996 organelle organization TAS --
genes like me logo Genes that share ontologies with TRIP11: view

No data available for Pathways by source for TRIP11 Gene

Transcripts for TRIP11 Gene

Unigene Clusters for TRIP11 Gene

Thyroid hormone receptor interactor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP11

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRIP11

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: -
SP2: -
SP3: - - - - -
SP4:

ExUns: 22b · 22c
SP1:
SP2:
SP3:
SP4:

Relevant External Links for TRIP11 Gene

GeneLoc Exon Structure for
TRIP11
ECgene alternative splicing isoforms for
TRIP11

Expression for TRIP11 Gene

mRNA expression in normal human tissues for TRIP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP11 Gene

SOURCE GeneReport for Unigene cluster for TRIP11 Gene Hs.632339

mRNA Expression by UniProt/SwissProt for TRIP11 Gene

Q15643-TRIPB_HUMAN
Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung.
genes like me logo Genes that share expressions with TRIP11: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIP11 Gene

Orthologs for TRIP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP11 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP11 35
  • 99.66 (n)
  • 99.65 (a)
TRIP11 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP11 35
  • 88.06 (n)
  • 86.63 (a)
TRIP11 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP11 35
  • 88.16 (n)
  • 86.92 (a)
TRIP11 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip11 35
  • 82.97 (n)
  • 83.04 (a)
Trip11 16
Trip11 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP11 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP11 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip11 35
  • 82.4 (n)
  • 82.48 (a)
chicken
(Gallus gallus)
Aves TRIP11 35
  • 72.18 (n)
  • 68.24 (a)
TRIP11 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIP11 36
  • 63 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trip11 35
  • 58.42 (n)
  • 54.37 (a)
trip11 36
  • 53 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Gmap 36
  • 21 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea sql-1 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
OneToOne
Species with no ortholog for TRIP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP11 Gene

ENSEMBL:
Gene Tree for TRIP11 (if available)
TreeFam:
Gene Tree for TRIP11 (if available)

Paralogs for TRIP11 Gene

Selected SIMAP similar genes for TRIP11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRIP11: view

No data available for Paralogs for TRIP11 Gene

Variants for TRIP11 Gene

Sequence variations from dbSNP and Humsavar for TRIP11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs910368 -- 92,022,550(+) AAAGG(A/C)GGGTA intron-variant
rs1051340 - 91,974,722(-) AGGGC(A/G)GTGTT missense, reference
rs1061983 -- 92,040,346(+) TGTTG(A/G)AACCT upstream-variant-2KB
rs1133441 -- 91,968,721(-) TTGAG(A/T)TCCAT utr-variant-3-prime
rs1468745 -- 91,994,673(+) ACCTC(C/T)GACAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP11 Gene

Variant ID Type Subtype PubMed ID
dgv1974n71 CNV Loss 21882294
dgv1975n71 CNV Loss 21882294
nsv902188 CNV Loss 21882294
nsv527458 CNV Loss 19592680
nsv523854 CNV Gain 19592680
nsv902190 CNV Loss 21882294
nsv456395 CNV Loss 19166990

Relevant External Links for TRIP11 Gene

HapMap Linkage Disequilibrium report
TRIP11
Human Gene Mutation Database (HGMD)
TRIP11

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP11 Gene

Disorders for TRIP11 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (2) Diseases for TRIP11 Gene including...

Search for TRIP11 Gene in MalaCards »

(1) OMIM Diseases for TRIP11 Gene (604505)

UniProtKB/Swiss-Prot

TRIPB_HUMAN
  • Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia.
  • Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO:0000269 PubMed:20089971}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(1) University of Copenhagen DISEASES for TRIP11 Gene

Relevant External Links for TRIP11

Genetic Association Database (GAD)
TRIP11
Human Genome Epidemiology (HuGE) Navigator
TRIP11
genes like me logo Genes that share disorders with TRIP11: view

Publications for TRIP11 Gene

  1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PMID: 9373237) Abe A. … Saito H. (Blood 1997) 2 3 4 23
  2. GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PMID: 10189370) Infante C. … Rios R.M. (J. Cell Biol. 1999) 3 4 23
  3. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP- 210. (PMID: 20089971) Smits P. … Beier D.R. (N. Engl. J. Med. 2010) 3 4 23
  4. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3 4
  5. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4

Products for TRIP11 Gene

  • antibodies-online proteins for TRIP11
  • antibodies-online antibodies for TRIP11
  • antibodies-online kits for TRIP11

Sources for TRIP11 Gene

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