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Aliases & Descriptions for TRIP11
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CEV14 1, 2, 3, 5 | | GMAP-210 1, 2, 3 | | TRIP-11 3 | | TRIP230 2, 5 | | Trip230 1, 3 |
| | | Descriptions |
|---|
| Clonal evolution-related gene on chromosome 14 3 | | Golgi-associated microtubule-binding protein 210 3 | | thyroid hormone receptor interactor 11 2 | | thyroid receptor interacting protein 11 2 |
|
| | Search outside databases for aliases for TRIP11 genePrevious GC identifers: GC14M089942 GC14M086251 GC14M090423 GC14M090425 |
Summaries for TRIP11(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for TRIP11: TRIP11 was first identified through its ability to interact functionally with thyroid hormone receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus and microtubules.[supplied by OMIM] UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structureGene Wiki entry for TRIP11 |
Genomic Location for TRIP11
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the TRIP11 gene 
Entrez Gene cytogenetic band: 14q31-q32 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q31-q32TRIP11 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M091505:
(about GC identifiers)
Start:
|
91,505,614 bp from pter |
End:
|
91,576,139 bp from pter |
Size:
|
70,526 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000014.7 NT_026437.11
| Proteins for TRIP11
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643 (See
protein sequence)Recommended Name: Thyroid receptor-interacting protein 11 Size: 1979 amino acids; 227639 Da
Subunit: Binds RB1
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Note=Associates with the ends of centrosome-nucleated microtubules
Sequence caution: Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955;
Secondary accessions: O14689 O15154 O95949Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_004230.2
ENSEMBL proteins: ENSP00000267622
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for TRIP11: Assays for TRIP11: | Protein
Domains/ Families for TRIP11(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q15643
ProtoNet protein and cluster: Q15643 UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Domain: Extended rod-like protein with coiled-coil domainsSimilarity: Contains 1 GRIP domain | Gene Function for TRIP11
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004239
Applied Biosystems Silencer® siRNAs for TRIP11
Sigma-Aldrich siRNA for TRIP11  Sigma-Aldrich shRNA for TRIP11  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004239                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004239                                  untagged cDNA clone in CMV expression vector: NM_004239 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_004239
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structureGenatlas biochemistry entry for TRIP11:thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastoma protein9 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Trip11):
2 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for TRIP11
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for TRIP11 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for TRIP11 
5/8 Interacting proteins for TRIP11 (ENSP000002676223 Q156432) via UniProtKB, MINT, and/or STRING (see all 8
)About this table
1 Gene Ontology (GO) biological process term (links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9256431 | About this table
|
Drugs & Compounds for TRIP11(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for TRIP11
|
Transcripts for TRIP11(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004239
Sigma-Aldrich siRNA for TRIP11  Sigma-Aldrich shRNA for TRIP11  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_004239 REFSEQ mRNAs for TRIP11 gene: NM_004239.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_004239               OriGene GFP tagged cDNA clone in CMV expression vector: NM_004239                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_004239                                  untagged cDNA clone in CMV expression vector: NM_004239  Additional cDNA sequence: AF007217.1 AF011368.1 AK307489.1 BC002656.2 BC069008.1 BC142956.1 BC146845.1 BX641024.1 L40380.1 Y12490.1 9 DOTS entries: DT.97794586 DT.414189 DT.100648346 DT.92425194 DT.414190 DT.120758503 DT.120758516 DT.100000967 DT.100654818 24/170 AceView cDNA sequences (see all 170
):BG993233 BU620572 BU679515 BX641024 BQ428389 CN485016 AI627541 CK300229 BU628691 AI061045 AA653343 AI566379 AA723550 BF975735 AW769117 BU171803 BG943113 AA768353 Y12490 AU138211 AL599917 AL705417 BX113797 BU685330
highest scoring ESTs for TRIP11:Y12490 AF007217 AL599917 AL603123 BC002656 BC069008 BE384427 BE390254 BE391670 BG477910 Unigene Cluster for TRIP11: Thyroid hormone receptor interactor 11 Hs.632339 [show with all ESTs]Unigene Representative Sequence: NM_004239
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | - |   | - |   | - |   | - |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
| ExUns: | 22b | · | 22c | |
| SP1: | |   | |   | |
| SP2: | |   | |   | |
| SP3: | |   | |   | |
| SP4: | |   | |   |
About this scheme
ECgene alternative splicing isoforms for TRIP11
1 Ensembl transcript including schematic representation: ENST00000267622
|
Expression for TRIP11
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| TRIP11 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for TRIP11
1 / 2 / 3 5 probe-sets matching TRIP11 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TATTTGTTCG
SOURCE GeneReport for Unigene cluster: Hs.632339
Expression variation in blood from EXPOLDB for TRIP11 UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung |
Orthologs for TRIP11
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for TRIP11 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for TRIP11
ENSEMBL Gene Tree for TRIP11 | Paralogs for TRIP11(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for TRIP11(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for TRIP11 (up to first 250kb)
|
Disorders & Mutations for TRIP11
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 604505
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophiliaHuman Genome Epidemiology Navigator: TRIP11 (2 documents)
|
Medical News for TRIP11(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for TRIP11 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/21 PubMed articles for TRIP11 gene (see all 21
):- Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PubMed id 9373237)1, 2, 3, 4 Abe A....Saito H. (1997)
- Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)2, 3, 4 Lee J.W....Moore D.D. (1995)
- GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PubMed id 10189370)1, 3, 4 Infante C.... Rios R.M. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)3, 4 Olsen J.V....Mann M. (2006)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)3, 4 Heilig R.... Weissenbach J. (2003)
- A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. (PubMed id 9256431)3, 4 Chang K.-H.... Lee W.-H. (1997)
- The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus. (PubMed id 12383348)1, 3 Pernet-Gallay K....Rios R.M. (2002)
- Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)3 Sovio U....Jarvelin M.R. (2009)
- DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome. (PubMed id 18987736)4 Ley T.J.... Wilson R.K. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)3 Barbe L....Andersson-Svahn H. (2008)
|
Search for TRIP11
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TRIP11
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing TRIP11
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIP11(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for TRIP11(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for TRIP11:

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