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Aliases for TRIP11 Gene

Aliases for TRIP11 Gene

  • Thyroid Hormone Receptor Interactor 11 2 3 5
  • Clonal Evolution-Related Gene On Chromosome 14 Protein 3 4
  • Golgi-Associated Microtubule-Binding Protein 210 3 4
  • TR-Interacting Protein 11 3 4
  • GMAP-210 3 4
  • TRIP230 3 4
  • TRIP-11 3 4
  • CEV14 3 4
  • Golgi-Microtubule-Associated Protein Of 210 KDa 3
  • GMAP210 3
  • ACG1A 3

External Ids for TRIP11 Gene

Previous GeneCards Identifiers for TRIP11 Gene

  • GC14M089942
  • GC14M086251
  • GC14M090423
  • GC14M090425
  • GC14M091505
  • GC14M092435
  • GC14M072615

Summaries for TRIP11 Gene

Entrez Gene Summary for TRIP11 Gene

  • This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

GeneCards Summary for TRIP11 Gene

TRIP11 (Thyroid Hormone Receptor Interactor 11) is a Protein Coding gene. Diseases associated with TRIP11 include achondrogenesis, type ia and achondrogenesis. Among its related pathways are Organelle biogenesis and maintenance and Vesicle-mediated transport. GO annotations related to this gene include transcription coactivator activity and structural constituent of ribosome.

UniProtKB/Swiss-Prot for TRIP11 Gene

  • Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Gene Wiki entry for TRIP11 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP11 Gene

Genomics for TRIP11 Gene

Regulatory Elements for TRIP11 Gene

Promoters for TRIP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIP11 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIP11 Gene

91,965,991 bp from pter
92,040,896 bp from pter
74,906 bases
Minus strand

Genomic View for TRIP11 Gene

Genes around TRIP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP11 Gene

Proteins for TRIP11 Gene

  • Protein details for TRIP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyroid receptor-interacting protein 11
    Protein Accession:
    Secondary Accessions:
    • B2RUT2
    • O14689
    • O15154
    • O95949

    Protein attributes for TRIP11 Gene

    1979 amino acids
    Molecular mass:
    227586 Da
    Quaternary structure:
    • Binds RB1.
    • Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955; Evidence={ECO:0000305};

neXtProt entry for TRIP11 Gene

Proteomics data for TRIP11 Gene at MOPED

Post-translational modifications for TRIP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIP11 Gene

No data available for DME Specific Peptides for TRIP11 Gene

Domains & Families for TRIP11 Gene

Protein Domains for TRIP11 Gene


Suggested Antigen Peptide Sequences for TRIP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Extended rod-like protein with coiled-coil domains.
  • Contains 1 GRIP domain.
genes like me logo Genes that share domains with TRIP11: view

No data available for Gene Families for TRIP11 Gene

Function for TRIP11 Gene

Molecular function for TRIP11 Gene

GENATLAS Biochemistry:
thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastoma protein
UniProtKB/Swiss-Prot Function:
Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.
genes like me logo Genes that share phenotypes with TRIP11: view

Human Phenotype Ontology for TRIP11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIP11 Gene

Localization for TRIP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP11 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules.

Subcellular locations from

Jensen Localization Image for TRIP11 Gene COMPARTMENTS Subcellular localization image for TRIP11 gene
Compartment Confidence
golgi apparatus 5
nucleus 5
cytoskeleton 4
cytosol 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002079 inner acrosomal membrane IEA --
GO:0002081 outer acrosomal membrane IEA --
GO:0005622 intracellular IEA --
GO:0030133 transport vesicle TAS --
genes like me logo Genes that share ontologies with TRIP11: view

Pathways & Interactions for TRIP11 Gene

genes like me logo Genes that share pathways with TRIP11: view

SIGNOR curated interactions for TRIP11 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:1903506 regulation of nucleic acid-templated transcription TAS 9256431
genes like me logo Genes that share ontologies with TRIP11: view

Drugs & Compounds for TRIP11 Gene

No Compound Related Data Available

Transcripts for TRIP11 Gene

Unigene Clusters for TRIP11 Gene

Thyroid hormone receptor interactor 11:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: -
SP2: -
SP3: - - - - -

ExUns: 22b · 22c

Relevant External Links for TRIP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIP11 Gene

mRNA expression in normal human tissues for TRIP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIP11 Gene

This gene is overexpressed in Platelet (45.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP11 Gene

SOURCE GeneReport for Unigene cluster for TRIP11 Gene Hs.632339

mRNA Expression by UniProt/SwissProt for TRIP11 Gene

Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung.
genes like me logo Genes that share expression patterns with TRIP11: view

Protein tissue co-expression partners for TRIP11 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TRIP11 Gene

Orthologs for TRIP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIP11 35
  • 88.06 (n)
  • 86.63 (a)
TRIP11 36
  • 86 (a)
(Canis familiaris)
Mammalia TRIP11 35
  • 88.16 (n)
  • 86.92 (a)
TRIP11 36
  • 87 (a)
(Mus musculus)
Mammalia Trip11 35
  • 82.97 (n)
  • 83.04 (a)
Trip11 16
Trip11 36
  • 83 (a)
(Pan troglodytes)
Mammalia TRIP11 35
  • 99.66 (n)
  • 99.65 (a)
TRIP11 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trip11 35
  • 82.4 (n)
  • 82.48 (a)
(Monodelphis domestica)
Mammalia TRIP11 36
  • 73 (a)
(Ornithorhynchus anatinus)
Mammalia TRIP11 36
  • 74 (a)
(Gallus gallus)
Aves TRIP11 35
  • 72.18 (n)
  • 68.24 (a)
TRIP11 36
  • 67 (a)
(Anolis carolinensis)
Reptilia TRIP11 36
  • 63 (a)
(Danio rerio)
Actinopterygii trip11 35
  • 58.42 (n)
  • 54.37 (a)
trip11 36
  • 53 (a)
fruit fly
(Drosophila melanogaster)
Insecta Gmap 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea sql-1 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 35 (a)
Species with no ortholog for TRIP11:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP11 Gene

Gene Tree for TRIP11 (if available)
Gene Tree for TRIP11 (if available)

Paralogs for TRIP11 Gene

(1) SIMAP similar genes for TRIP11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRIP11: view

No data available for Paralogs for TRIP11 Gene

Variants for TRIP11 Gene

Sequence variations from dbSNP and Humsavar for TRIP11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs141259390 - 91,974,664(+) AAGGT(A/G)TGTTG downstream-variant-500B, reference, missense
rs17127898 - 92,039,571(+) CTCCA(A/T)CAGCA nc-transcript-variant, reference, missense
rs2273186 - 92,007,650(+) TAGCT(G/T)CTTGA nc-transcript-variant, reference, missense
rs34699762 - 92,005,593(+) CAAAA(C/G/T)GTCCT intron-variant, nc-transcript-variant, reference, missense
rs34967261 - 92,005,325(+) TAGGG(C/T)CAGCC intron-variant, nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIP11 Gene

Variant ID Type Subtype PubMed ID
dgv1974n71 CNV Loss 21882294
dgv1975n71 CNV Loss 21882294
nsv902188 CNV Loss 21882294
nsv527458 CNV Loss 19592680
nsv523854 CNV Gain 19592680
nsv902190 CNV Loss 21882294
nsv456395 CNV Loss 19166990

Variation tolerance for TRIP11 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.54; 95.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIP11 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP11 Gene

Disorders for TRIP11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIP11 Gene - From: OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
achondrogenesis, type ia
  • achondrogenesis type ia
  • achondrogenesis syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO:0000269 PubMed:20089971}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. {ECO:0000269 PubMed:9373237}.

Relevant External Links for TRIP11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIP11: view

No data available for Genatlas for TRIP11 Gene

Publications for TRIP11 Gene

  1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PMID: 9373237) Abe A. … Saito H. (Blood 1997) 2 3 4 23 67
  2. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP- 210. (PMID: 20089971) Smits P. … Beier D.R. (N. Engl. J. Med. 2010) 3 23
  3. The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus. (PMID: 12383348) Pernet-Gallay K. … Rios R.M. (Traffic 2002) 3 23
  4. GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PMID: 10189370) Infante C. … Rios R.M. (J. Cell Biol. 1999) 3 23
  5. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee J.W. … Moore D.D. (Mol. Endocrinol. 1995) 2 3

Products for TRIP11 Gene

Sources for TRIP11 Gene

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