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TRIP11 Gene

protein-coding   GIFtS: 58
GCID: GC14M092435

Thyroid Hormone Receptor Interactor 11

  See TRIP11-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Interactor 111 2     TR-Interacting Protein 112 3
CEV142 3 5     ACG1A2 5
Clonal Evolution-Related Gene On Chromosome 14 Protein2 3     TRIP2302 5
Golgi-Associated Microtubule-Binding Protein 2102 3     Golgi-Microtubule-Associated Protein Of 210 KDa2
GMAP-2102 3     Thyroid Receptor-Interacting Protein 112
TRIP-112 3     Trip2303

External Ids:    HGNC: 123051   Entrez Gene: 93212   Ensembl: ENSG000001008157   OMIM: 6045055   UniProtKB: Q156433   

Export aliases for TRIP11 gene to outside databases

Previous GC identifers: GC14M089942 GC14M086251 GC14M090423 GC14M090425 GC14M091505 GC14M072615


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIP11 Gene:
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This
protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and
the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in
assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause
achondrogenesis type IA.(provided by RefSeq, Mar 2010)

GeneCards Summary for TRIP11 Gene:
TRIP11 (thyroid hormone receptor interactor 11) is a protein-coding gene. Diseases associated with TRIP11 include achondrogenesis type ia, and achondrogenesis. GO annotations related to this gene include transcription coactivator activity.

UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and
enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

Gene Wiki entry for TRIP11 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIP11 gene promoter:
         C/EBPbeta   Pax-5   HOXA3   FOXD1   Pax-2   Pax-2a   Ik-2   CP2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP11 promoter sequence
   Search Chromatin IP Primers for TRIP11

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIP11


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q31-q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q31-q32

TRIP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP11 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M092435:  view genomic region     (about GC identifiers)

Start:
92,432,335 bp from pter      End:
92,507,240 bp from pter
Size:
74,906 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643 (See protein sequence)
Recommended Name: Thyroid receptor-interacting protein 11  
Size: 1979 amino acids; 227586 Da
Subunit: Binds RB1
Sequence caution: Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955;
Secondary accessions: O14689 O15154 O95949

Explore the universe of human proteins at neXtProt for TRIP11: NX_Q15643

Explore proteomics data for TRIP11 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIP11 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004230.2  
    ENSEMBL proteins: 
     ENSP00000267622   ENSP00000451032   ENSP00000451607   ENSP00000451944  

    TRIP11 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIP11

     
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    antibodies-online proteins for TRIP11 (2 products) 

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR000237 GRIP

    Graphical View of Domain Structure for InterPro Entry Q15643

    ProtoNet protein and cluster: Q15643

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
    Domain: Extended rod-like protein with coiled-coil domains
    Similarity: Contains 1 GRIP domain


    Find genes that share domains with TRIP11           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIPB_HUMAN, Q15643
    Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and
    enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure

         Genatlas biochemistry entry for TRIP11:
    thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the
    retinoblastoma protein

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713transcription coactivator activity TAS9256431
    GO:0003735structural constituent of ribosome ----
    GO:0005515protein binding IPI17438371
         
    Find genes that share ontologies with TRIP11           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIP11:
     Decreased homologous recombina  Synthetic lethal with imatinib 

         11 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trip11):
     behavior/neurological  cardiovascular system  cellular  craniofacial  growth/size/body 
     homeostasis/metabolism  limbs/digits/tail  mortality/aging  nervous system  respiratory system 
     skeleton 

    Find genes that share phenotypes with TRIP11           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIP11
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    miRNA
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    miRTarBase miRNAs that target TRIP11:
    hsa-mir-124-3p (MIRT002692)

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    Selected qRT-PCR Assays for microRNAs that regulate TRIP11 (see all 44):
    hsa-miR-124* hsa-miR-549 hsa-miR-520e hsa-miR-302d hsa-miR-15a hsa-miR-106a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTRIP11 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIPB_HUMAN, Q15643: Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm,
    cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus4
    nucleus4
    cytosol2

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005794Golgi apparatus IDA--
    GO:0005840ribosome ----
    GO:0005856cytoskeleton IEA--

    Find genes that share ontologies with TRIP11           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIP11
    Interactions:

        GeneGlobe Interaction Network for TRIP11

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRIP11 (Q156432, 3 ENSP000002676224) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HLA-BP304803, ENSP000003991684I2D: score=1 STRING: ENSP00000399168
    ARNTP275403, ENSP000003514074I2D: score=2 STRING: ENSP00000351407
    RB1P064003, ENSP000002671634I2D: score=3 STRING: ENSP00000267163
    THRAP108273, ENSP000002646374I2D: score=1 STRING: ENSP00000264637
    TRIP6Q156543, ENSP000002004574I2D: score=1 STRING: ENSP00000200457
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000042protein targeting to Golgi IEA--
    GO:0003281ventricular septum development IEA--
    GO:0006366transcription from RNA polymerase II promoter TAS9256431
    GO:0006412translation ----
    GO:2001141regulation of RNA biosynthetic process TAS9256431

    Find genes that share ontologies with TRIP11           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIP11 (TRIPB)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIP11 gene: 
    NM_004239.3  

    Unigene Cluster for TRIP11:

    Thyroid hormone receptor interactor 11
    Hs.632339  [show with all ESTs]
    Unigene Representative Sequence: NM_004239
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000267622(uc010auf.2 uc001xzy.3) ENST00000554357 ENST00000557017
    ENST00000555516 ENST00000555105(uc001xzz.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIP11 (see all 44):
    hsa-miR-124* hsa-miR-549 hsa-miR-520e hsa-miR-302d hsa-miR-15a hsa-miR-106a hsa-miR-424 hsa-miR-372
    SwitchGear 3'UTR luciferase reporter plasmidTRIP11 3' UTR sequence
    Inhib. RNA
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      QuantiFast Probe-based Assays in human, mouse, rat TRIP11

    Additional mRNA sequence: 

    AF007217.1 AF011368.1 AK307489.1 BC002656.2 BC069008.1 BC142956.1 BC146845.1 BX641024.1 
    L40380.1 Y12490.1 

    9 DOTS entries:

    DT.97794586  DT.414190  DT.100648346  DT.414189  DT.92425194  DT.100000967  DT.120758503  DT.120758516 
    DT.100654818 

    Selected AceView cDNA sequences (see all 170):

    AW769117 Y12490 AL705417 BX113797 BU676122 BU620572 BF975735 CD675579 
    BM510053 AI061045 BU685330 BM422430 AA723550 BG943113 BC002656 CK300229 
    BG993233 CN485016 BQ428389 BE384427 AI566379 AA768353 AL599917 BU679515 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:                    -                                                                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                                                    -     -     -     -     -               
    SP4:                                                                                                                                                            

    ExUns: 22b · 22c
    SP1:            
    SP2:            
    SP3:            
    SP4:            


    ECgene alternative splicing isoforms for TRIP11

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIP11 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATTTGTTCG
    TRIP11 Expression
    About this image


    TRIP11 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             pre Conventional Dendritic Cells Peripheral Blood
     
     Eye (Sensory Organs)
             Retina
    TRIP11 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIP11 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.632339

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
    Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in
    several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain
    and lung

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP11

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIP11 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip111 , 5 thyroid hormone receptor interactor 111, 5 82.97(n)1
    83.04(a)1
      12 (51.30 cM)5
    1091811  NM_028446.11  NP_082722.11 
     1018340435 
    chicken
    (Gallus gallus)
    Aves TRIP111 thyroid hormone receptor interactor 11 72.18(n)
    68.24(a)
      423414  XM_421324.3  XP_421324.3 
    lizard
    (Anolis carolinensis)
    Reptilia TRIP116
    thyroid hormone receptor interactor 11
    63(a)
    1 ↔ 1
    1(11674864-11723069)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480591952   -- 79.44(n)    48059195 
    zebrafish
    (Danio rerio)
    Actinopterygii trip111 thyroid hormone receptor interactor 11 58.42(n)
    54.37(a)
      100537975  NM_001278703.1  NP_001265632.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Gmap6
    Golgi microtubule-associated protein
    21(a)
    1 ↔ 1
    X(15380955-15404816)
    worm
    (Caenorhabditis elegans)
    Secernentea sql-16
    Protein Y111B2A.4, isoform a (Y111B2A.4) mRNA, com...
    21(a)
    1 ↔ 1
    III(12499561-12527819) WBGene00013730


    ENSEMBL Gene Tree for TRIP11 (if available)
    TreeFam Gene Tree for TRIP11 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIP11 gene
    1 SIMAP similar gene for TRIP11 using alignment to 5 protein entries:     TRIPB_HUMAN (see all proteins):
    DKFZp686C06243

    Find genes that share paralogs with TRIP11           About GenesLikeMe


    5 Pseudogenes.org Pseudogenes for TRIP11
    PGOHUM00000261840 PGOHUM00000258686 PGOHUM00000248765 PGOHUM00000249023 PGOHUM00000249026


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIP11 (see all 1711)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1395394481,2
    C,Fpathogenic179163924(+) GCTGAT/CTGTTA 2 /N /S mis12Minor allele frequency- C:0.00NA EU 5557
    rs740716501,2
    C,F--72614775(+) AGGAAA/GTACTC 1 -- ds50012Minor allele frequency- G:0.20WA 120
    rs1412057571,2
    --72614788(+) AAATGG/TCACAA 1 -- ds50010--------
    rs1827465151,2
    --72614807(+) TCAAAC/TATGAT 1 -- ds50010--------
    rs1469960611,2
    C--72614879(+) CATATG/TCTATT 1 -- ds50010--------
    rs118485121,2
    C,F,A,H--72615104(+) ACTTGC/TATGAC 1 -- ut3119Minor allele frequency- T:0.10NS EA NA WA 2142
    rs118485451,2
    C,F,H--72615294(+) CAGTAA/TAACTT 1 -- ut3117Minor allele frequency- T:0.06NS EA NA WA 1986
    rs1877160471,2
    --72615327(+) GGCCTC/TAGCCA 1 -- ut310--------
    rs748018261,2
    C,F--72615474(+) AAATAT/GGAACA 1 -- ut312Minor allele frequency- G:0.08NA EA 240
    rs352512901,2
    C--72615509(+) CGGGA-/TTTTTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIP11 (92432335 - 92507240 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRIP11:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902188CNV Loss21882294
    dgv1975n71CNV Loss21882294
    dgv1974n71CNV Loss21882294
    nsv902190CNV Loss21882294
    nsv527458CNV Loss19592680
    nsv456395CNV Loss19166990
    nsv523854CNV Gain19592680

    Human Gene Mutation Database (HGMD): TRIP11
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIP11
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIP11

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604505   
    OMIM disorders: 200600  
    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
  • Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia.
    Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia
    and eosinophilia
  • Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of
    chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the
    sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia,
    there is a disproportionately large cranium due to marked edema of soft tissues. Note=The disease is caused by
    mutations affecting the gene represented in this entry

  • 3 diseases for TRIP11:    
    About MalaCards
    achondrogenesis type ia    achondrogenesis    mucopolysaccharidosis iii

    1 disease from the University of Copenhagen DISEASES database for TRIP11:
    Achondrogenesis

    Find genes that share disorders with TRIP11           About GenesLikeMe

    Genetic Association Database (GAD): TRIP11
    Human Genome Epidemiology (HuGE) Navigator: TRIP11 (4 documents)

    Export disorders for TRIP11 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIP11 gene, integrated from 10 sources (see all 38):
    (articles sorted by number of sources associating them with TRIP11)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PubMed id 9373237)1, 2, 3, 9 Abe A.... Saito H. (Blood 1997)
    2. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    3. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP- 210. (PubMed id 20089971)1, 2, 9 Smits P.... Beier D.R. (N. Engl. J. Med. 2010)
    4. GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PubMed id 10189370)1, 2, 9 Infante C.... Rios R.M. (J. Cell Biol. 1999)
    5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PubMed id 20546612)1, 4 Zhao J....Grant S.F. (BMC Med. Genet. 2010)
    6. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    7. Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966. (PubMed id 19266077)1, 4 Sovio U....Jarvelin M.R. (PLoS Genet. 2009)
    8. Many sequence variants affecting diversity of adult human height. (PubMed id 18391951)1, 4 Gudbjartsson D.F....Stefansson K. (Nat. Genet. 2008)
    9. Identification of ten loci associated with height highlights new biological pathways in human growth. (PubMed id 18391950)1, 4 Lettre G.... Hirschhorn J.N. (Nat. Genet. 2008)
    10. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9321 HGNC: 12305 AceView: TRIP11 Ensembl:ENSG00000100815 euGenes: HUgn9321
    ECgene: TRIP11 H-InvDB: TRIP11

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIP11 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIP11 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRIP11 gene:
    Search GeneIP for patents involving TRIP11

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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