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Aliases for TRIP11 Gene

Aliases for TRIP11 Gene

  • Thyroid Hormone Receptor Interactor 11 2 3 5
  • Clonal Evolution-Related Gene On Chromosome 14 Protein 3 4
  • Golgi-Associated Microtubule-Binding Protein 210 3 4
  • TR-Interacting Protein 11 3 4
  • GMAP-210 3 4
  • TRIP230 3 4
  • TRIP-11 3 4
  • CEV14 3 4
  • Golgi-Microtubule-Associated-Protein Of 210 KDa 2
  • Golgi-Microtubule-Associated Protein Of 210 KDa 3
  • Thyroid Receptor-Interacting Protein 11 3
  • GMAP210 3
  • ACG1A 3

External Ids for TRIP11 Gene

Previous GeneCards Identifiers for TRIP11 Gene

  • GC14M089942
  • GC14M086251
  • GC14M090423
  • GC14M090425
  • GC14M091505
  • GC14M092435
  • GC14M072615

Summaries for TRIP11 Gene

Entrez Gene Summary for TRIP11 Gene

  • This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. This protein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and the C-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly and maintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis type IA.[provided by RefSeq, Mar 2010]

GeneCards Summary for TRIP11 Gene

TRIP11 (Thyroid Hormone Receptor Interactor 11) is a Protein Coding gene. Diseases associated with TRIP11 include Achondrogenesis, Type Ia and Achondrogenesis. Among its related pathways are Golgi-to-ER retrograde transport and Intraflagellar transport. GO annotations related to this gene include transcription coactivator activity and structural constituent of ribosome.

UniProtKB/Swiss-Prot for TRIP11 Gene

  • Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Gene Wiki entry for TRIP11 Gene

Additional gene information for TRIP11 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP11 Gene

Genomics for TRIP11 Gene

Regulatory Elements for TRIP11 Gene

Enhancers for TRIP11 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H091077 0.9 ENCODE 61.5 +962.6 962553 1 TBL1XR1 ZFP64 BATF ZNF121 ATF7 ETV6 RUNX3 CREM IKZF2 ZNF202 TRIP11 PPP4R3A NRDE2 RPS18P2 RPL21P11 RPS6KA5 RNU7-30P
GH14H091267 1 dbSUPER 28.9 +773.1 773093 0.6 ATF1 TCF12 ZNF121 ZNF766 GATA2 ELK1 ATF7 CAVIN1 NCOA1 ZC3H11A TRIP11 NRDE2 RPL21P11 PPP4R3A ATXN3 RPS18P2 GPR68 ENSG00000260810
GH14H091112 1.6 Ensembl ENCODE dbSUPER 16.7 +923.8 923766 8.4 HDGF PKNOX1 ATF1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF121 DGLUCY TRIP11 PPP4R3A NRDE2 RNU7-30P ATXN3 RPS6KA5 RPS18P2 RPL21P11 GC14P091127
GH14H091360 2 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +669.9 669852 21.8 HDGF PKNOX1 FOXA2 SIN3A ARID4B FEZF1 DMAP1 ZNF2 ZNF143 ZNF207 CCDC88C PPP4R3A RPS18P2 ATXN3 TRIP11 ENSG00000258875 ENSG00000260711 RPS6KA5 GC14M091833 PIR43651
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIP11 on UCSC Golden Path with GeneCards custom track

Promoters for TRIP11 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000072176 1196 2601 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 CBX5 ZNF207

Genomic Locations for TRIP11 Gene

Genomic Locations for TRIP11 Gene
74,906 bases
Minus strand

Genomic View for TRIP11 Gene

Genes around TRIP11 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIP11 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIP11 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP11 Gene

Proteins for TRIP11 Gene

  • Protein details for TRIP11 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Thyroid receptor-interacting protein 11
    Protein Accession:
    Secondary Accessions:
    • B2RUT2
    • O14689
    • O15154
    • O95949

    Protein attributes for TRIP11 Gene

    1979 amino acids
    Molecular mass:
    227586 Da
    Quaternary structure:
    • Binds RB1.
    • Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955; Evidence={ECO:0000305};

neXtProt entry for TRIP11 Gene

Post-translational modifications for TRIP11 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIP11 Gene

No data available for DME Specific Peptides for TRIP11 Gene

Domains & Families for TRIP11 Gene

Gene Families for TRIP11 Gene

Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for TRIP11 Gene


Suggested Antigen Peptide Sequences for TRIP11 Gene

Graphical View of Domain Structure for InterPro Entry



  • Extended rod-like protein with coiled-coil domains.
  • Extended rod-like protein with coiled-coil domains.
genes like me logo Genes that share domains with TRIP11: view

Function for TRIP11 Gene

Molecular function for TRIP11 Gene

GENATLAS Biochemistry:
thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastoma protein
UniProtKB/Swiss-Prot Function:
Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure.

Phenotypes From GWAS Catalog for TRIP11 Gene

Gene Ontology (GO) - Molecular Function for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003713 transcription coactivator activity TAS 9256431
GO:0005515 protein binding IPI 17438371
genes like me logo Genes that share ontologies with TRIP11: view
genes like me logo Genes that share phenotypes with TRIP11: view

Human Phenotype Ontology for TRIP11 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIP11 Gene

Localization for TRIP11 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP11 Gene

Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm, cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIP11 gene
Compartment Confidence
nucleus 5
golgi apparatus 5
cytoskeleton 4
cytosol 2
endoplasmic reticulum 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (4)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane TAS --
GO:0002079 inner acrosomal membrane IEA --
GO:0002080 acrosomal membrane IEA --
GO:0002081 outer acrosomal membrane IEA --
GO:0005634 nucleus IDA --
genes like me logo Genes that share ontologies with TRIP11: view

Pathways & Interactions for TRIP11 Gene

genes like me logo Genes that share pathways with TRIP11: view

SIGNOR curated interactions for TRIP11 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for TRIP11 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003281 ventricular septum development IEA --
GO:0003413 chondrocyte differentiation involved in endochondral bone morphogenesis IEA --
GO:0006366 transcription from RNA polymerase II promoter TAS 9256431
GO:0006486 protein glycosylation IEA --
GO:0007030 Golgi organization IEA --
genes like me logo Genes that share ontologies with TRIP11: view

Drugs & Compounds for TRIP11 Gene

No Compound Related Data Available

Transcripts for TRIP11 Gene

Unigene Clusters for TRIP11 Gene

Thyroid hormone receptor interactor 11:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
SP1: -
SP2: -
SP3: - - - - -

ExUns: 22b · 22c

Relevant External Links for TRIP11 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIP11 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIP11 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIP11 Gene

This gene is overexpressed in Platelet (45.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIP11 Gene

Protein tissue co-expression partners for TRIP11 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIP11 Gene:


SOURCE GeneReport for Unigene cluster for TRIP11 Gene:


mRNA Expression by UniProt/SwissProt for TRIP11 Gene:

Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung.

Evidence on tissue expression from TISSUES for TRIP11 Gene

  • Nervous system(4.2)
  • Thyroid gland(2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIP11 Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
  • cardiovascular
  • digestive
  • integumentary
  • nervous
  • reproductive
  • respiratory
  • skeletal muscle
  • skeleton
Head and neck:
  • brain
  • chin
  • ear
  • face
  • forehead
  • head
  • jaw
  • lip
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • skull
  • chest wall
  • clavicle
  • heart
  • lung
  • rib
  • rib cage
  • scapula
  • sternum
  • abdominal wall
  • intestine
  • kidney
  • liver
  • pelvis
  • placenta
  • uterus
  • ankle
  • arm
  • digit
  • elbow
  • femur
  • fibula
  • finger
  • foot
  • forearm
  • hand
  • hip
  • humerus
  • knee
  • lower limb
  • radius
  • shin
  • shoulder
  • thigh
  • tibia
  • toe
  • ulna
  • upper limb
  • wrist
  • skin
  • spinal column
  • vertebrae
genes like me logo Genes that share expression patterns with TRIP11: view

Primer Products

No data available for mRNA differential expression in normal tissues for TRIP11 Gene

Orthologs for TRIP11 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP11 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIP11 33 34
  • 99.66 (n)
(Canis familiaris)
Mammalia TRIP11 33 34
  • 88.16 (n)
(Bos Taurus)
Mammalia TRIP11 33 34
  • 88.06 (n)
(Mus musculus)
Mammalia Trip11 33 16 34
  • 82.97 (n)
(Rattus norvegicus)
Mammalia Trip11 33
  • 82.4 (n)
(Ornithorhynchus anatinus)
Mammalia TRIP11 34
  • 74 (a)
(Monodelphis domestica)
Mammalia TRIP11 34
  • 73 (a)
(Gallus gallus)
Aves TRIP11 33 34
  • 72.18 (n)
(Anolis carolinensis)
Reptilia TRIP11 34
  • 63 (a)
(Danio rerio)
Actinopterygii trip11 33 34
  • 58.42 (n)
fruit fly
(Drosophila melanogaster)
Insecta Gmap 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea sql-1 34
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 35 (a)
Species where no ortholog for TRIP11 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP11 Gene

Gene Tree for TRIP11 (if available)
Gene Tree for TRIP11 (if available)

Paralogs for TRIP11 Gene

(1) SIMAP similar genes for TRIP11 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRIP11: view

No data available for Paralogs for TRIP11 Gene

Variants for TRIP11 Gene

Sequence variations from dbSNP and Humsavar for TRIP11 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs139539448 Pathogenic 92,005,874(+) GCTGA(C/T)TGTTA nc-transcript-variant, reference, missense
rs267607138 Pathogenic 92,015,729(-) AAGAA(A/C/T)GAATT nc-transcript-variant, reference, stop-gained, utr-variant-5-prime
rs863223281 Pathogenic 92,025,422(-) TTTCT(A/G)GAATG splice-acceptor-variant
rs111335604 Likely benign 91,969,427(+) AAAGA(C/T)AAATT utr-variant-3-prime
rs111671120 Likely benign 91,969,063(+) CAACA(C/G/T)AGTGA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIP11 Gene

Variant ID Type Subtype PubMed ID
nsv977498 CNV duplication 23825009
nsv565519 CNV loss 21841781
nsv527458 CNV loss 19592680
nsv523854 CNV gain 19592680
nsv456395 CNV loss 19166990
nsv1134398 CNV deletion 24896259
nsv1045760 CNV gain 25217958

Variation tolerance for TRIP11 Gene

Residual Variation Intolerance Score: 91.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 13.54; 95.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIP11 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP11 Gene

Disorders for TRIP11 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIP11 Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
achondrogenesis, type ia
  • achondrogenesis type ia
  • achondrogenesis syndrome
- elite association - COSMIC cancer census association via MalaCards


  • Achondrogenesis 1A (ACG1A) [MIM:200600]: A form of achondrogenesis type 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absent ossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severe micromelia, there is a disproportionately large cranium due to marked edema of soft tissues. {ECO:0000269 PubMed:20089971}. Note=The disease is caused by mutations affecting the gene represented in this entry.
  • Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia. {ECO:0000269 PubMed:9373237}.

Relevant External Links for TRIP11

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIP11: view

No data available for Genatlas for TRIP11 Gene

Publications for TRIP11 Gene

  1. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PMID: 9373237) Abe A … Saito H (Blood 1997) 2 3 4 22 60
  2. Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. (PMID: 20089971) Smits P … Beier DR (The New England journal of medicine 2010) 3 4 22 60
  3. GMAP-210, A cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PMID: 10189370) Infante C … Rios RM (The Journal of cell biology 1999) 3 4 22 60
  4. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PMID: 7776974) Lee JW … Moore DD (Molecular endocrinology (Baltimore, Md.) 1995) 2 3 4 60
  5. The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature. (PMID: 20546612) Zhao J … Grant SF (BMC medical genetics 2010) 3 45 60

Products for TRIP11 Gene

Sources for TRIP11 Gene

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