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TRIP11 Gene

protein-coding   GIFtS: 59

GC14M091505
thyroid hormone receptor interactor 11
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases
CEV14 1, 2, 3, 5
GMAP-210 1, 2, 3
TRIP-11 3
TRIP230 2, 5
Trip230 1, 3
Descriptions
Clonal evolution-related gene on chromosome 14 3
Golgi-associated microtubule-binding protein 210 3
thyroid hormone receptor interactor 11 2
thyroid receptor interacting protein 11 2
External Ids
HGNC: 123051
Entrez Gene: 93212
UniProtKB: Q156433
Ensembl: ENSG000001008157
Search outside databases for aliases for TRIP11 gene

Previous GC identifers: GC14M089942 GC14M086251 GC14M090423 GC14M090425

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for TRIP11:
TRIP11 was first identified through its ability to interact functionally with thyroid hormone
receptor-beta (THRB; MIM 190160). It has also been found in association with the Golgi apparatus
and microtubules.[supplied by OMIM]

UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of
triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved
in maintaining cis-Golgi structure

Gene Wiki entry for TRIP11

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the TRIP11 gene  

Entrez Gene cytogenetic band: 14q31-q32   Ensembl cytogenetic band:  14q32.12   HGNC cytogenetic band: 14q31-q32

TRIP11 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M091505:     (about GC identifiers)

Start:
91,505,614 bp from pter
End:
91,576,139 bp from pter
Size:
70,526 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000014.7  NT_026437.11  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643 (See protein sequence)
Recommended Name: Thyroid receptor-interacting protein 11  
Size: 1979 amino acids; 227639 Da
Subunit: Binds RB1
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein.
Note=Associates with the ends of centrosome-nucleated microtubules
Sequence caution: Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955;
Secondary accessions: O14689 O15154 O95949

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_004230.2  

    ENSEMBL proteins: 
    ENSP00000267622 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (TRIP230)
    Human Recombinant Proteins from Abnova (TRIP11)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 

    3 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA18029348
    GO:0005794 Golgi apparatus IEA--
    GO:0016020 membrane IEA--
    About this table

    Antibodies for TRIP11: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for TRIP11
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (TRIP230), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Novus Biologicals Antibodies for TRIP11

    Assays for TRIP11: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    1 InterPro domain/family:
     IPR000237 GRIP


       GeneDecks  TRIP11 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q15643

    ProtoNet protein and cluster: Q15643

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
    Domain: Extended rod-like protein with coiled-coil domains
    Similarity: Contains 1 GRIP domain

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TRIP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TRIP11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004239

                  Applied Biosystems Silencer® siRNAs for TRIP11

                  Sigma-Aldrich siRNA for TRIP11  
                         Sigma-Aldrich shRNA for TRIP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004239
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004239
                                     untagged cDNA clone in CMV expression vector: NM_004239 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_004239

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
    Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of
    triiodothyronine and enhances THRB-modulated transcription. Golgi auto-antigen; probably involved
    in maintaining cis-Golgi structure

    Genatlas biochemistry entry for TRIP11:
    thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated
    by the retinoblastoma protein

    9 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trip11):

    behavior/neurologicalcellularcraniofacialembryogenesis
    growth/sizehomeostasis/metabolismlethality-prenatal/perinatalrespiratory system

    2 Gene Ontology (GO) molecular function terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003713 transcription coactivator activity TAS9256431
    GO:0005515 protein binding IPI17438371
    About this table

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section


    1 Sigma-Aldrich "Your Favorite Gene" Pathway for  TRIP11  (Your Favorite Gene powered by Ingenuity) 
     Aryl Hydrocarbon Receptor Signaling

       GeneDecks  TRIP11 for the pathways selected above  
    About GeneDecksing

     Gene Network CentralTM Interacting Genes and Proteins Network for  TRIP11 


    5/8 Interacting proteins for TRIP11 (ENSP000002676223 Q156432) via UniProtKB, MINT, and/or STRING (see all 8 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PDGFRBENSP000002617993STRING (score=.903)
    ARF1ENSP000002721023STRING (score=.809)
    RB1ENSP000002671633STRING (score=.808)
    ARNTENSP000003156373STRING (score=.79)
    ETV6ENSP000002664273STRING (score=.743)
    About this table

    1 Gene Ontology (GO) biological process term (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006366 transcription from RNA polymerase II promoter TAS9256431
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for TRIP11

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section

    Inhib.
    RNA:
    Invitrogen RNAi Products for gene knock-down (TRIP11)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (TRIP11)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004239

                  Sigma-Aldrich siRNA for TRIP11  
                         Sigma-Aldrich shRNA for TRIP11  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_004239  

    REFSEQ mRNAs for TRIP11 gene: 

    NM_004239.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_004239  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_004239
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_004239
                                     untagged cDNA clone in CMV expression vector: NM_004239 

    Additional cDNA sequence: 

    AF007217.1 AF011368.1 AK307489.1 BC002656.2 BC069008.1 BC142956.1 BC146845.1 BX641024.1 
    L40380.1 Y12490.1 

    9 DOTS entries:

    DT.97794586  DT.414189  DT.100648346  DT.92425194  DT.414190  DT.120758503  DT.120758516  DT.100000967 
    DT.100654818 

    24/170 AceView cDNA sequences (see all 170 ):

    BG993233 BU620572 BU679515 BX641024 BQ428389 CN485016 AI627541 CK300229 
    BU628691 AI061045 AA653343 AI566379 AA723550 BF975735 AW769117 BU171803 
    BG943113 AA768353 Y12490 AU138211 AL599917 AL705417 BX113797 BU685330 

    highest scoring ESTs for TRIP11:

    Y12490 AF007217 AL599917 AL603123 BC002656 BC069008 BE384427 BE390254 BE391670 BG477910 

    Unigene Cluster for TRIP11:

    Thyroid hormone receptor interactor 11
    Hs.632339  [show with all ESTs]
    Unigene Representative Sequence: NM_004239


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a ·
    SP1:                    -                                                                                                                                       
    SP2:                                                                    -                                                                                       
    SP3:                                                                                                                    -     -     -     -     -               
    SP4:                                                                                                                                                            

    ExUns: 22b · 22c
    SP1:            
    SP2:            
    SP3:            
    SP4:            

    About this scheme

    ECgene alternative splicing isoforms for TRIP11

    1 Ensembl transcript including schematic representation:
    ENST00000267622  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    TRIP11 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for TRIP11

    1 / 2 / 3

    5 probe-sets matching TRIP11 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    37932_at2, 3 U95-A 1 1.00 1.00 1.00 1.00 Y12490 1.00 1.00 1.00 1

    209778_at2, 3 U133-A 1 1.00 1.00 -- -- AF007217 0.80 1.00 0.91 1

    210760_x_at2, 3 U133-A 21 1.00 0.84 -- -- BC002656 0.80 1.00 0.91 1

    209778_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    210760_x_at2 U133Plus2 21 1.00 0.84 -- -- -- -- -- -- --
    GeneDecks  TRIP11 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: TATTTGTTCG

    SOURCE GeneReport for Unigene cluster: Hs.632339

    Expression variation in blood from EXPOLDB for TRIP11

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
    Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood
    leukocytes, and in several leukemia cell lines. Detected at intermediate levels in placenta and
    kidney, and at low levels in brain and lung

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for TRIP11 gene from 5/10 species (see all 10 )
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    TRIP111   -- thyroid hormone receptor interactor 11 88.15(n)
    86.94(a)
    480228  XM_537351.2  XP_537351.2 
    chimpanzee
    (Pan troglodytes)
    TRIP111   -- thyroid hormone receptor interactor 11 99.61(n)
    99.55(a)
    453113  XM_510128.2  XP_510128.2 
    cow
    (Bos taurus)
    TRIP111   -- thyroid hormone receptor interactor 11 89.75(n)
    88.51(a)
    786261  XM_001254003.1  XP_001254004.1 
    rat
    (Rattus norvegicus)
    Trip111   -- thyroid hormone receptor interactor 11 82.42(n)
    82.54(a)
    314393  XM_234490.4  XP_234490.4 
    mouse
    (Mus musculus)
    Trip111, 5 125
    thyroid hormone receptor interactor 111, 5 83.02(n)1
    83.09(a)1
    1091811  XM_001001171.21  XP_001001171.11 
     AI4507765  AK0121125  (see all 16)
    About this table        Species with no ortholog for TRIP11

    ENSEMBL Gene Tree for TRIP11
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

      --
    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/458 NCBI SNPs in TRIP11 are shown (see all 458 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 156)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    rs118513761,2
    A,C,F,H91524386(+) TTTGTC/TTTTTA 1 R/K mis1 ese39Minor allele frequency- T:0.04EU EA WA NA 912
    rs10513401,2
    C,F,H,O91510819(-) AGGGCG/AGTGTT 1 S/G mis114Minor allele frequency- A:0.43MN NA EU EA WA 1422
    rs118516401,2
    A,C,F,H91576762(+) CATACG/TATGAG 1 -- ng314Minor allele frequency- T:0.02EU EA WA 416
    rs19556841,2
    C,F,H91576450(+) ACCTAG/ATGTTT 1 -- ut514Minor allele frequency- A:0.05EU EA WA 418
    rs171278981,2
    C,F,H91575668(+) CTCCAT/ACAGCA 1 L/M mis1 ese311Minor allele frequency- A:0.02NA EU EA WA 964
    --
    rs125872481,2
    C,F,H91505340(+) CTTTCT/CGCACT 1 -- ut317Minor allele frequency- C:0.37EU EA WA NA 560
    rs22731861,2
    C,F,H91543747(+) TAGCTT/GCTTGA 1 A/E mis18Minor allele frequency- G:0.01EU EA WA 816
    --
    rs22731831,2
    C,F,H91524395(+) TAAGTT/GCTTCA 1 A/E mis14Minor allele frequency- G:0.01EU EA WA 406
    rs19556831,2
    F,H91576113(+) AACTCG/CACGCC 1 -- ut51 ese34Minor allele frequency- C:0.06EU EA WA 418
    --
    rs171277861,2
    F,H91505425(+) TCTCTA/GGCTTA 1 -- ut317Minor allele frequency- G:0.02NA EU EA WA 560
    About this table

    HapMap Linkage Disequilibrium images for TRIP11 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 604505

    UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
  • A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia.
    Translocation t(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution
    of leukemia and eosinophilia
  • Human Genome Epidemiology Navigator: TRIP11 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/21 PubMed articles for TRIP11 gene (see all 21 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 9321 HGNC: 12305 AceView: TRIP11 Ensembl:ENSG00000100815 euGenes: HUgn9321
    ECgene: TRIP11 H-InvDB: TRIP11
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    ATLAS Chromosomes in Cancer entry for TRIP11 Genetics and Cytogenetics in Oncology and Haematology
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for TRIP11:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
      Free SNP selection tool



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     Predesigned and custom siRNAs for TRIP11 Antibodies for TRIP11
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for TRIP11 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant Proteins
    (TRIP230)
     Antibodies (TRIP230)
     Search OriGene for TRIP11
     Search Tocris compounds for TRIP11




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for TRIP11

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