TRIP11 Gene
protein-coding GIFtS: 54
GCID: GC14M092435
|
|
thyroid hormone receptor interactor 11
| |
Aliases
for TRIP11 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Thyroid Hormone Receptor Interactor 111 2 | | TRIP-112 3 | | CEV141 2 3 5 | | TR-Interacting Protein 112 3 | | GMAP-2101 2 3 | | ACG1A2 5 | | Trip2301 3 | | TRIP2302 5 | | Clonal Evolution-Related Gene On Chromosome 14 Protein2 3 | | Golgi-Microtubule-Associated Protein Of 210 KDa2 | | Golgi-Associated Microtubule-Binding Protein 2102 3 | | Thyroid Receptor-Interacting Protein 112 |
Export aliases for TRIP11 gene to outside databasesPrevious GC identifers: GC14M089942 GC14M086251 GC14M090423 GC14M090425 GC14M091505 GC14M072615 |
Summaries
for TRIP11 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIP11:
This gene was identified based on the interaction of its protein product with thyroid hormone receptor beta. Thisprotein is associated with the Golgi apparatus. The N-terminal region of the protein binds Golgi membranes and theC-terminal region binds the minus ends of microtubules; thus, the protein is thought to play a role in assembly andmaintenance of the Golgi ribbon structure around the centrosome. Mutations in this gene cause achondrogenesis typeIA.(provided by RefSeq, Mar 2010)
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine andenhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure
Gene Wiki entry for TRIP11
|
Genomic Views
for TRIP11 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000014.8 NC_018925.1 NT_026437.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIP11 gene promoter:
C/EBPbeta Pax-5 HOXA3 FOXD1 Pax-2 Pax-2a Ik-2 CP2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIP11
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP11 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 14q31-q32 Ensembl cytogenetic band: 14q32.12 HGNC cytogenetic band: 14q31-q32TRIP11 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 14 GeneLoc Exon Structure GeneLoc location for GC14M092435: view genomic region
(about GC identifiers)
Start:
|
92,432,335 bp from pter |
End:
|
92,507,241 bp from pter |
Size:
|
74,907 bases |
Orientation:
|
minus strand |
|
Proteins
for TRIP11 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643 (See
protein sequence)Recommended Name: Thyroid receptor-interacting protein 11 Size: 1979 amino acids; 227586 Da
Subunit: Binds RB1
Subcellular location: Golgi apparatus, cis-Golgi network membrane; Peripheral membrane protein. Cytoplasm,cytoskeleton. Note=Associates with the ends of centrosome-nucleated microtubules
Sequence caution: Sequence=AAB84386.1; Type=Frameshift; Positions=1932, 1955;
Secondary accessions: O14689 O15154 O95949Explore the universe of human proteins at neXtProt for TRIP11: NX_Q15643
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q15643
TRIP11 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004230.2
ENSEMBL proteins: ENSP00000267622 ENSP00000451032 ENSP00000451607 ENSP00000451944
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
TRIP11 for ontologies About GeneDecksing
TRIP11 Antibody Products:
Assay Products for TRIP11: |
Protein
Domains /
Families
for TRIP11 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIP11 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q15643ProtoNet protein and cluster: Q15643 UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Domain: Extended rod-like protein with coiled-coil domainsSimilarity: Contains 1 GRIP domain |
Function
for TRIP11 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Function: Binds the ligand binding domain of the thyroid receptor (THRB) in the presence of triiodothyronine andenhances THRB-modulated transcription. Golgi auto-antigen; probably involved in maintaining cis-Golgi structure Genatlas biochemistry entry for TRIP11:thyroid receptor interacting protein 11,expressed in a wide range of tissues,negatively regulated by the retinoblastomaprotein
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP11
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP11 |
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table
TRIP11 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TRIP11:
Animal Models:
11 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Trip11):
TRIP11 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRIP11 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIP11
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/13 Interacting proteins for TRIP11 (Q156432, 3 ENSP000002676224) via UniProtKB, MINT, STRING, and/or I2D (see all 13)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0000042 | protein targeting to Golgi |
IEA | -- | | GO:0006366 | transcription from RNA polymerase II promoter |
TAS | 9256431 |
TRIP11 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIP11 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIP11
Search CenterWatch for drugs/clinical trials and news about TRIP11 / TRIPB
|
Transcripts
for TRIP11 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIP11 gene: NM_004239.3 Unigene Cluster for TRIP11: Thyroid hormone receptor interactor 11 Hs.632339 [show with all ESTs]Unigene Representative Sequence: NM_0042395 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000267622(uc010auf.2 uc001xzy.3) ENST00000554357 ENST00000557017
ENST00000555516 ENST00000555105(uc001xzz.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP11 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIP11
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIP11 (NM_004239) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIP11 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP11 |
Additional cDNA sequence: AF007217.1 AF011368.1 AK307489.1 BC002656.2 BC069008.1 BC142956.1 BC146845.1 BX641024.1 L40380.1 Y12490.1 9 DOTS entries: DT.97794586 DT.414190 DT.100648346 DT.414189 DT.92425194 DT.100000967 DT.120758503 DT.120758516 DT.100654818 24/170 AceView cDNA sequences (see all 170): AL705417 BU628691 Y12490 CN485016 CK300229 AL599917 BE384427 BC002656 CD104915 BG943113 AI627541 BM422430 BX113797 BU679515 BU620572 AI566379 NM_004239 BF975735 BU171803 AA768353 BU685330 BM510053 CD675579 BQ428389
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP11 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21a | · | 21b | ^ | 22a | · |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| ExUns: | 22b | · | 22c |
|---|
|
| SP1: | | | | | |
| SP2: | | | | | |
| SP3: | | | | | |
| SP4: | | | | |
ECgene alternative splicing isoforms for TRIP11
|
Expression
for TRIP11 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIP11 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TATTTGTTCG
About this image
See TRIP11 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIP11
SOURCE GeneReport for Unigene cluster: Hs.632339
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643Tissue specificity: Highly expressed in pancreas, muscle, heart, testis, peripheral blood leukocytes, and in severalleukemia cell lines. Detected at intermediate levels in placenta and kidney, and at low levels in brain and lung
SABiosciences Custom PCR Arrays for TRIP11
Primer
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Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP11 |
Orthologs
for TRIP11 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRIP11 gene from 6/21 species (see all 21) About this table
ENSEMBL Gene Tree for TRIP11 (if available)
TreeFam Gene Tree for TRIP11 (if available) |
Paralogs
for TRIP11 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIP11 gene
- GOLGA42 GCC22 CEP2502 AKAP92 PCNT2 LOC7287632 CROCC2 EEA12
- NUMA12 CENPF2 CNTRL2 GOLGB12
1 SIMAP similar gene for TRIP11 using alignment to 5 protein entries: TRIPB_HUMAN (see all proteins):DKFZp686C06243
TRIP11 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for TRIP11
PGOHUM00000261840 PGOHUM00000258686 PGOHUM00000248765 PGOHUM00000249023 PGOHUM00000249026
|
Genomic Variants
for TRIP11 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 14 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIP11 (92432335 - 92507241 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRIP11: --
Human Gene Mutation Database (HGMD): TRIP11
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIP11 |
|
Disorders
/ Diseases
for TRIP11 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIP11 for disorders About GeneDecksing
OMIM gene information: 604505
OMIM disorders: 200600
UniProtKB/Swiss-Prot: TRIPB_HUMAN, Q15643
Note=A chromosomal aberration involving TRIP11 may be a cause of acute myelogenous leukemia. Translocationt(5;14)(q33;q32) with PDGFRB. The fusion protein may be involved in clonal evolution of leukemia and eosinophilia Defects in TRIP11 are the cause of achondrogenesis type 1A (ACG1A) [MIM:200600]. A form of achondrogenesistype 1, a lethal form of chondrodysplasia characterized by deficient ossification in the lumbar vertebrae and absentossification in the sacral, pubic and ischial bones and clinically by stillbirth or early death. In addition to severemicromelia, there is a disproportionately large cranium due to marked edema of soft tissues
9  diseases for TRIP11: About MalaCardsachondrogenesis type ia achondrogenesis thyroiditis achondrogenesis type 1a
myeloproliferative disorder chondrodysplasia retinoblastoma hypoxia
leukemia
1 disease from the University of Copenhagen DISEASES database for TRIP11:Achondrogenesis Human Genome Epidemiology (HuGE) Navigator: TRIP11 (4 documents)
Export disorders for TRIP11 gene to outside databases
|
Publications
for TRIP11 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIP11 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with TRIP11) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. (PubMed id 9373237)1, 2, 3, 9 Abe A....Saito H. (1997)
- Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W....Moore D.D. (1995)
- Lethal skeletal dysplasia in mice and humans lacking the golgin GMAP-210. (PubMed id 20089971)1, 2, 9 Smits P....Beier D.R. (2010)
- GMAP-210, a cis-Golgi network-associated protein, is a minus end microtubule-binding protein. (PubMed id 10189370)1, 2, 9 Infante C.... Rios R.M. (1999)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
- A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein. (PubMed id 9256431)1, 2 Chang K.-H.... Lee W.-H. (1997)
- The overexpression of GMAP-210 blocks anterograde and retrograde transport between the ER and the Golgi apparatus. (PubMed id 12383348)1, 9 Pernet-Gallay K....Rios R.M. (2002)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyc losome substrate. (PubMed id 21628590)1 Emanuele M.J....Elledge S.J. (2011)
|
External Searches for TRIP11 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIP11 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIP11 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIP11 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRIP11 gene:
Search GeneIP for patents involving TRIP11
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIP11 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP11 |
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