Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIP10 Gene

Aliases for TRIP10 Gene

  • Thyroid Hormone Receptor Interactor 10 2 3
  • Thyroid Receptor-Interacting Protein 10 3 4
  • TR-Interacting Protein 10 3 4
  • Salt Tolerant Protein 3 4
  • Salt Tolerator 2 3
  • Protein Felic 3 4
  • TRIP-10 3 4
  • HSTP 3 4
  • STOT 3 4
  • CIP4 3 4
  • STP 3 4
  • Cdc42-Interacting Protein 4 3
  • Cdc42-Interacting Protein 2

External Ids for TRIP10 Gene

Previous HGNC Symbols for TRIP10 Gene

  • STOT

Previous GeneCards Identifiers for TRIP10 Gene

  • GC19P006834
  • GC19P006679
  • GC19P006690
  • GC19P006502

Summaries for TRIP10 Gene

GeneCards Summary for TRIP10 Gene

TRIP10 (Thyroid Hormone Receptor Interactor 10) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Rho GTPase cycle. GO annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is FNBP1L.

UniProtKB/Swiss-Prot for TRIP10 Gene

  • Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.

Gene Wiki entry for TRIP10 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIP10 Gene

Genomics for TRIP10 Gene

Regulatory Elements for TRIP10 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIP10 Gene

Start:
6,737,925 bp from pter
End:
6,751,526 bp from pter
Size:
13,602 bases
Orientation:
Plus strand

Genomic View for TRIP10 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIP10 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIP10 Gene

Proteins for TRIP10 Gene

  • Protein details for TRIP10 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15642-CIP4_HUMAN
    Recommended name:
    Cdc42-interacting protein 4
    Protein Accession:
    Q15642
    Secondary Accessions:
    • B2R8A6
    • B7WP22
    • D6W645
    • O15184
    • Q53G22
    • Q5TZN1
    • Q6FI24
    • Q8NFL1
    • Q8TCY1
    • Q8TDX3
    • Q96RJ1

    Protein attributes for TRIP10 Gene

    Size:
    601 amino acids
    Molecular mass:
    68352 Da
    Quaternary structure:
    • Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42. Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone. May interact with CTNNB1 and HD/HTT.

    Three dimensional structures from OCA and Proteopedia for TRIP10 Gene

    Alternative splice isoforms for TRIP10 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIP10 Gene

Proteomics data for TRIP10 Gene at MOPED

Post-translational modifications for TRIP10 Gene

Other Protein References for TRIP10 Gene

No data available for DME Specific Peptides for TRIP10 Gene

Domains for TRIP10 Gene

Protein Domains for TRIP10 Gene

Suggested Antigen Peptide Sequences for TRIP10 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q15642

UniProtKB/Swiss-Prot:

CIP4_HUMAN :
  • Q15642
Domain:
  • The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive tubulation.
  • Contains 1 F-BAR domain.
  • Contains 1 SH3 domain.
Family:
  • Belongs to the FNBP1 family.
Similarity:
  • Contains 1 REM (Hr1) repeat.
genes like me logo Genes that share domains with TRIP10: view

No data available for Gene Families for TRIP10 Gene

Function for TRIP10 Gene

Molecular function for TRIP10 Gene

UniProtKB/Swiss-Prot Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.
UniProtKB/Swiss-Prot Induction: Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during differentiation.

Gene Ontology (GO) - Molecular Function for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16318909
GO:0008289 lipid binding IEA --
GO:0042802 identical protein binding IPI 17512409
genes like me logo Genes that share ontologies with TRIP10: view
genes like me logo Genes that share phenotypes with TRIP10: view

Animal Models for TRIP10 Gene

MGI Knock Outs for TRIP10:

Animal Model Products

CRISPR Products

miRNA for TRIP10 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP10

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TRIP10 Gene

Localization for TRIP10 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIP10 Gene

Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9. {ECO:0000250}.
Isoform 5: Cytoplasm, perinuclear region.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIP10 Gene COMPARTMENTS Subcellular localization image for TRIP10 gene
Compartment Confidence
cytoskeleton 5
golgi apparatus 5
lysosome 5
plasma membrane 5
vacuole 5
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001891 phagocytic cup IEA --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm NAS 9210375
GO:0005764 lysosome IEA --
genes like me logo Genes that share ontologies with TRIP10: view

Pathways for TRIP10 Gene

genes like me logo Genes that share pathways with TRIP10: view

Pathways by source for TRIP10 Gene

2 BioSystems pathways for TRIP10 Gene
3 Reactome pathways for TRIP10 Gene
1 KEGG pathway for TRIP10 Gene

Gene Ontology (GO) - Biological Process for TRIP10 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006897 endocytosis IEA --
GO:0007154 cell communication NAS 9210375
GO:0007165 signal transduction TAS 9210375
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0030036 actin cytoskeleton organization NAS 9210375
genes like me logo Genes that share ontologies with TRIP10: view

Compounds for TRIP10 Gene

(125) HMDB Compounds for TRIP10 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
PS(14:0/14:0)
  • Phosphatidylserine(14:0/14:0)
Not Available
PS(14:0/14:1(9Z))
  • Phosphatidylserine(14:0/14:1n5)
Not Available
PS(14:0/16:0)
  • 1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine
Not Available
PS(14:0/16:1(9Z))
  • PS(14:0/16:1n7)
Not Available

(1) Novoseek inferred chemical compound relationships for TRIP10 Gene

Compound -log(P) Hits PubMed IDs
tyrosine 18.1 1
genes like me logo Genes that share compounds with TRIP10: view

Transcripts for TRIP10 Gene

Unigene Clusters for TRIP10 Gene

Thyroid hormone receptor interactor 10:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIP10

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIP10 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - -
SP4: - - - - - - - -
SP5: - - - - - - - - - - - -
SP6: - - -
SP7:
SP8: - - - - -
SP9:
SP10: - -
SP11: - - -
SP12:

ExUns: 15 ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for TRIP10 Gene

GeneLoc Exon Structure for
TRIP10
ECgene alternative splicing isoforms for
TRIP10

Expression for TRIP10 Gene

mRNA expression in normal human tissues for TRIP10 Gene

mRNA differential expression in normal tissues according to GTEx for TRIP10 Gene

This gene is overexpressed in Muscle - Skeletal (4.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIP10 Gene

SOURCE GeneReport for Unigene cluster for TRIP10 Gene Hs.515094

mRNA Expression by UniProt/SwissProt for TRIP10 Gene

Q15642-CIP4_HUMAN
Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea.
genes like me logo Genes that share expressions with TRIP10: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIP10 Gene

Orthologs for TRIP10 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIP10 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIP10 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIP10 35
  • 87.91 (n)
  • 92.68 (a)
TRIP10 36
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIP10 35
  • 89.24 (n)
  • 94.12 (a)
TRIP10 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trip10 35
  • 82.11 (n)
  • 88.29 (a)
Trip10 16
Trip10 36
  • 89 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIP10 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIP10 36
  • 61 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trip10 35
  • 78.86 (n)
  • 85.85 (a)
zebrafish
(Danio rerio)
Actinopterygii TRIP10 (1 of 2) 36
  • 55 (a)
OneToMany
TRIP10 (2 of 2) 36
  • 49 (a)
OneToMany
zgc56292 35
zgc:101777 35
  • 62.37 (n)
  • 62.43 (a)
fruit fly
(Drosophila melanogaster)
Insecta Cip4 36
  • 29 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea toca-1 36
  • 24 (a)
ManyToMany
toca-2 36
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
OneToMany
Species with no ortholog for TRIP10:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIP10 Gene

ENSEMBL:
Gene Tree for TRIP10 (if available)
TreeFam:
Gene Tree for TRIP10 (if available)

Paralogs for TRIP10 Gene

Paralogs for TRIP10 Gene

Selected SIMAP similar genes for TRIP10 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TRIP10: view

Variants for TRIP10 Gene

Sequence variations from dbSNP and Humsavar for TRIP10 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10947 -- 6,751,219(-) TCTCT(A/G)GCAGG utr-variant-3-prime, reference, stop-gained, nc-transcript-variant, downstream-variant-500B
rs163365 -- 6,748,890(+) CATAG(A/G)GGAGA intron-variant
rs163912 -- 6,747,256(+) gaaat(G/T)gagac intron-variant
rs167973 -- 6,746,341(+) ATGGC(C/T)TCGCT intron-variant, downstream-variant-500B
rs168148 -- 6,748,864(+) TAGTC(A/G)TGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIP10 Gene

Variant ID Type Subtype PubMed ID
nsv470120 CNV Loss 18288195
dgv3703n71 CNV Loss 21882294
dgv14e196 CNV Duplication 17116639
nsv910940 CNV Loss 21882294
nsv519827 CNV Loss 19592680
nsv910941 CNV Loss 21882294
nsv910942 CNV Loss 21882294
nsv519561 CNV Loss 19592680

Relevant External Links for TRIP10 Gene

HapMap Linkage Disequilibrium report
TRIP10

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIP10 Gene

Disorders for TRIP10 Gene

(1) University of Copenhagen DISEASES for TRIP10 Gene

(1) Novoseek inferred disease relationships for TRIP10 Gene

Disease -log(P) Hits PubMed IDs
wiskott-aldrich syndrome 77.4 2
genes like me logo Genes that share disorders with TRIP10: view

No data available for UniProtKB/Swiss-Prot for TRIP10 Gene

Publications for TRIP10 Gene

  1. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. (PMID: 9210375) Aspenstroem P. (Curr. Biol. 1997) 2 3 4 23
  2. Molecular cloning and chromosomal localization of human salt-tolerant protein. (PMID: 11294612) Tsuji E. … Tsuji Y. (Genetica 2000) 2 3 4 23
  3. Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. (PMID: 11691828) Yuan R.-Q. … Rosen E.M. (Cancer Res. 2001) 3 4 23
  4. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. (PMID: 12604778) Holbert S. … Neri C. (Proc. Natl. Acad. Sci. U.S.A. 2003) 3 4 23
  5. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. (PMID: 10713100) Tian L. … Stewart D.M. (J. Biol. Chem. 2000) 3 4 23

Products for TRIP10 Gene

Sources for TRIP10 Gene

Back to Top

Content