Aliases for TRIP10 Gene
External Ids for TRIP10 Gene
Previous HGNC Symbols for TRIP10 Gene
Previous GeneCards Identifiers for TRIP10 Gene
GeneCards Summary for TRIP10 Gene
TRIP10 (Thyroid Hormone Receptor Interactor 10) is a Protein Coding gene. Diseases associated with TRIP10 include Wiskott-Aldrich Syndrome. Among its related pathways are Vesicle-mediated transport and Regulation of lipid metabolism Insulin signaling-generic cascades. Gene Ontology (GO) annotations related to this gene include identical protein binding and lipid binding. An important paralog of this gene is FNBP1L.
UniProtKB/Swiss-Prot for TRIP10 Gene
Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL.