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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRIP10 Gene

protein-coding GIFtS: 60
GCID: GC19P006690

thyroid hormone receptor interactor 10

(Previous name: salt tolerator )
(Previous symbol: STOT)

Explore 7 diseases affiliated with
TRIP10 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Thyroid Hormone Receptor Interactor 10¹ ²		Salt Tolerant Protein² ³
CIP4¹ ² ³		Thyroid Receptor-Interacting Protein 10² ³
STOT¹ ² ³		TRIP-10² ³
STP¹ ² ³		TR-Interacting Protein 10² ³
HSTP¹ ²		Cdc42-Interacting Protein 4²
Salt Tolerator¹ ²		Thyroid Receptor Interacting Protein 10²
Protein Felic² ³		HSTP¹ ²

External Ids:	HGNC: 12304¹	Entrez Gene: 9322²	Ensembl: ENSG00000125733⁷	OMIM: 604504⁵	UniProtKB: Q15642³

Export aliases for TRIP10 gene to outside databases

Previous GC identifers: GC19P006834 GC19P006679 GC19P006502

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642

Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity).

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to

lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the

formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn

activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic

vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells.

May be required for the lysosomal retention of FASLG/FASL

Gene Wiki entry for TRIP10

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011255.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRIP10 gene promoter:
PPAR-gamma1 AP-1 ATF-2 STAT3 PPAR-gamma2 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIP10 promoter sequence

Search SABiosciences Chromatin IP Primers for TRIP10

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIP10

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3

TRIP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP10 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P006690: view genomic region (about GC identifiers)

Start:	6,739,707 bp from pter	End:	6,751,529 bp from pter
Size:	11,823 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642 (See protein sequence)

Recommended Name: Cdc42-interacting protein 4

Size: 601 amino acids; 68352 Da

Subunit: Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes, the

dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42.

Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP and

WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid hormone.

May interact with CTNNB1 and HD/HTT

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane. Cell

projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and this may

require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes and to sites

of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9

Subcellular location: Isoform 5: Cytoplasm, perinuclear region

3 PDB 3D structures from and Proteopedia for TRIP10:

2CT4 (3D)

2EFK (3D)

2KE4 (3D)

Secondary accessions: B2R8A6 B7WP22 D6W645 O15184 Q53G22 Q5TZN1 Q6FI24 Q8NFL1 Q8TCY1 Q8TDX3 Q96RJ1

Alternative splicing: 5 isoforms: Q15642-1 Q15642-2 Q15642-3 Q15642-4 Q15642-5 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIP10: NX_Q15642

Post-translational modifications:

Tyrosine phosphorylated. Also phosphorylated by PKA¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q15642

TRIP10 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004231.1

ENSEMBL proteins:

ENSP00000320117 ENSP00000320493

Reactome Protein details: Q15642
Human Recombinant Protein Products for TRIP10:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRIP10

Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001891	phagocytic cup	IEA	--
GO:0005737	cytoplasm	NAS	9210375
GO:0005764	lysosome	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005829	cytosol	TAS	--

TRIP10 for ontologies About GeneDecksing

TRIP10 Antibody Products:

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	GenScript Custom Assay Services for TRIP10
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRIP10

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRIP10 for domains About GeneDecksing

2 InterPro domains/families:

IPR001060 FCH

IPR001452 SH3_domain

Graphical View of Domain Structure for InterPro Entry Q15642

ProtoNet protein and cluster: Q15642

2 Blocks protein families:

IPB001060 Cdc15/Fes/CIP4

IPB001452 SH3 domain signature

UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642

Domain: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization of

dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may drive

tubulation

Similarity: Belongs to the FNBP1 family

Similarity: Contains 1 FCH domain

Similarity: Contains 1 REM (Hr1) repeat

Similarity: Contains 1 SH3 domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CIP4_HUMAN, Q15642

Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By similarity).

Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to

lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the

formation of tubules. Also promotes CDC42-induced actin polymerization by recruiting WASL/N-WASP which in turn

activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic

vesicles. Required for the formation of podosomes, actin-rich adhesion structures specific to monocyte-derived cells.

May be required for the lysosomal retention of FASLG/FASL

Induction: Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during

differentiation

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	--	--
GO:0008289	lipid binding	IEA	--
GO:0042802	identical protein binding	IPI	18329367

TRIP10 for ontologies About GeneDecksing

Phenotypes:
4 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trip10):

adipose tissue

hematopoietic system

homeostasis/metabolism

immune system

TRIP10 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Trip10^tm1.1Geha for TRIP10

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TRIP10

miRNA Products:		OriGene 3'-UTR Clone: TRIP10 Browse MicroRNA Expression Plasmids
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		8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIP10 (see all 28):
		hsa-miR-142-5p hsa-miR-657 hsa-miR-106a hsa-miR-15a hsa-miR-519a hsa-miR-124 hsa-miR-424 hsa-miR-93

		SwitchGear 3'UTR luciferase reporter plasmid: TRIP10 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP10

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell death signalling via NRAGE, NRIF and NADE

Signaling by Rho GTPases

0.25

Rho GTPase cycle

0.25

Insulin Pathway

Insulin Pathway

1.00

Insulin-mediated glucose transport

Insulin-mediated glucose transport

1.00

Signaling by GPCR

Signal Transduction

0.56

Development_CNTF receptor signaling

Insulin signaling pathway

0.17

Pathway sources
See GeneCards unified pathways
Show all pathways

2 BioSystems Pathways for TRIP10

	Insulin-mediated glucose transport
	Insulin Pathway

3 Reactome Pathways for TRIP10

	Signaling by Rho GTPases
	Signal Transduction
	Rho GTPase cycle

1 Kegg Pathway (Kegg details for TRIP10):

Insulin signaling pathway

TRIP10 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRIP10

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/79 Interacting proteins for TRIP10 (Q15642^{1, 2, 3} ENSP00000320493⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 79)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DAAM1	Q9Y4D1²^,³, ENSP00000247170⁴	MINT-7146205 MINT-7146069 I2D: score=1 STRING: ENSP00000247170
WBP11	Q9Y2W2²^,³, ENSP00000261167⁴	MINT-66047 I2D: score=5 STRING: ENSP00000261167
LYN	P07948²^,³	MINT-50925 MINT-50926 I2D: score=2
FASLG	P48023²^,³, ENSP00000356694⁴	MINT-7137078 MINT-7137256 MINT-7137027 MINT-7137245 I2D: score=1 STRING: ENSP00000356694
CDC42	P60953²^,³, ENSP00000314458⁴	MINT-15379 MINT-50937 I2D: score=3 STRING: ENSP00000314458

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006897	endocytosis	IEA	--
GO:0007154	cell communication	NAS	9210375
GO:0007165	signal transduction	TAS	9210375
GO:0007264	small GTPase mediated signal transduction	TAS	--
GO:0030036	actin cytoskeleton organization	NAS	9210375

TRIP10 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

TRIP10 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIP10

10/125 HMDB Compounds for TRIP10 (see all 125) About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--
PS(14:0/14:0)	Phosphatidylserine(14:0/14:0) (see all 7)	--	--
PS(14:0/14:1(9Z))	Phosphatidylserine(14:0/14:1n5) (see all 13)	--	--
PS(14:0/16:0)	1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)	--	--
PS(14:0/16:1(9Z))	PS(14:0/16:1n7) (see all 13)	--	--
PS(14:0/18:0)	Phosphatidylserine(32:0) (see all 7)	--	--
PS(14:0/18:1(9Z))	PSer(14:0/18:1n9) (see all 13)	--	--
PS(14:0/18:2(9Z,12Z))	PS(14:0/18:2) (see all 13)	--	--
PS(14:0/18:3(9Z,12Z,15Z))	Phosphatidylserine(14:0/18:3) (see all 14)	--	--
PS(14:0/20:3(8Z,11Z,14Z))	PSer(14:0/20:3) (see all 14)	--	--

1 Novoseek chemical compound relationship for TRIP10 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	18.1	1	9210375 (1)

Search CenterWatch for drugs/clinical trials and news about TRIP10 / CIP4

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIP10 gene:

NM_004240.2

Unigene Cluster for TRIP10:

Thyroid hormone receptor interactor 10

Hs.515094 [show with all ESTs]

Unigene Representative Sequence: AF502289

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000313244(uc002mfs.3) ENST00000313285(uc010dux.2 uc002mfr.3 uc010duy.3)

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP10

Additional cDNA sequence:

AB007845.1 AB072596.1 AF380114.1 AF502289.1 AJ000414.1 AK223109.1 AK313296.1 AL832186.1

AY081141.1 BC013002.2 BT006698.1 BT020167.1 BT020171.1 CR536513.1 L40379.1

18 DOTS entries:

DT.417800 DT.95110854 DT.100641702 DT.100811272 DT.91748254 DT.92066548 DT.97847643 DT.100811271

DT.100811274 DT.40115429 DT.91748261 DT.100811269 DT.121446398 DT.121446403 DT.91827005 DT.92016799

DT.95234610 DT.91914775

24/302 AceView cDNA sequences (see all 302):

F32535 BM680963 BG575020 CD722036 CK300029 BX473367 BQ675251 F24760

AA583661 BE746661 CA311243 F30217 CD671097 NM_004240 AA618396 BM977998

AA134872 BQ186949 BE379164 BU527615 BU728643 BX280524 BM717195 BQ015712

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for TRIP10 (see all 12) About this scheme

ExUns:	1	^	2a	·	2b	^	3a	·	3b	·	3c	·	3d	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	^
SP1:							-		-		-														-		-														-				-
SP2:							-		-		-														-		-														-		-		-
SP3:																									-		-														-		-		-
SP4:							-		-		-														-		-														-		-		-
SP5:																									-				-		-		-		-		-		-		-		-		-		-		-

ExUns:	15	^	16	^	17a	·	17b	·	17c	·	17d	·	17e	·	17f
SP1:					-
SP2:					-
SP3:
SP4:
SP5:					-

ECgene alternative splicing isoforms for TRIP10

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIP10 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTTACATCT

About this image

TRIP10 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TRIP10 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIP10

SOURCE GeneReport for Unigene cluster: Hs.515094

UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642

Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas, peripheral

blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and trachea

SABiosciences Custom PCR Arrays for TRIP10

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIP10

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP10

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRIP10 gene from 4/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Trip10^{1 , 5}	thyroid hormone receptor interactor 10^{1, 5}	83.49(n)¹ 91.71(a)¹		17 (29.74 cM)⁵ 106628¹ NM_134125.4¹ NP_598886.1¹ 57249451⁵
zebrafish (Danio rerio)	Actinopterygii	zgc56292²	similar to thyroid hormone receptor interactor 10	69.81(n)		393193 BC046053.1
fruit fly (Drosophila melanogaster)	Insecta	Cip4⁶	Cip4	29(a)	1 → many	3L(4322491-4364102)
worm (Caenorhabditis elegans)	Secernentea	toca-1⁶ toca-2⁶	TOCA (Transducer Of Cdc42-dependent Actin assembly... TOCA (Transducer Of Cdc42-dependent Actin assembly...	22(a) 19(a)	many ↔ many many ↔ many	X(1511063-1521482) III(13755841-13759350)

ENSEMBL Gene Tree for TRIP10 (if available)
TreeFam Gene Tree for TRIP10 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRIP10 gene

FNBP1L² FNBP1²

3 SIMAP similar genes for TRIP10 using alignment to 5 protein entries: CIP4_HUMAN (see all proteins):

STP FNBP1 FNBP1L

TRIP10 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs55787415^1,2	C	--	6737711(+)	`AATTGC/TCTCTC`	2	--	us2k¹		1		WA	2
rs146216160^1,2		--	6737728(+)	`CCCGCA/CTGCTT`	2	--	us2k¹		0	--	--	--	--
rs139258837^1,2		--	6737730(+)	`CGCCTA/GCTTGC`	2	--	us2k¹		0	--	--	--	--
rs200038883^1,2		--	6737732(+)	`CCTGC-/TTGCGT`	2	--	us2k¹		0	--	--	--	--
rs181699379^1,2		--	6737779(+)	`GATAAA/CGCTTA`	2	--	us2k¹		0	--	--	--	--
rs142588891^1,2		--	6737787(+)	`TTAACC/TCCCAG`	2	--	us2k¹		0	--	--	--	--
rs56283203^1,2	C	--	6737830(+)	`GGATGC/TGATTT`	2	--	us2k¹		1		WA	2
rs148687170^1,2		--	6737868(+)	`ATGGAG/TCTGAT`	2	--	us2k¹		0	--	--	--	--
rs906332^1,2	F	--	6737943(+)	`TGCAGC/GGGGAG`	2	--	us2k¹ tfbs³		2		MN WA	302
rs186010981^1,2		--	6737958(+)	`CAAGGG/TCCACA`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TRIP10 (6739707 - 6751529 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for TRIP10
3 CNVs: 5341 5340 5342

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRIP10 for disorders           About GeneDecksing

OMIM gene information: 604504    OMIM disorders: --

7 diseases for TRIP10:    About MalaCards

wiskott-aldrich syndrome thyroiditis renal cell carcinoma huntington's disease

breast cancer carcinoma prostatitis

1 disease from the University of Copenhagen DISEASES database for TRIP10:

Wiskott-Aldrich syndrome

1 Novoseek disease relationship for TRIP10 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
wiskott-aldrich syndrome	77.4	4	17785506 (1), 12604778 (1)

Export disorders for TRIP10 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TRIP10 gene, integrated from 9 sources (see all 56):
(articles sorted by number of sources associating them with TRIP10)

Utopia: connect your pdf to the dynamic
world of online information

Molecular cloning and chromosomal localization of human salt-tolerant protein. (PubMed id 11294612)^{1, 2, 3, 9} Tsuji E. and Tsuji Y. (2000)
A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. (PubMed id 9210375)^{1, 2, 3, 9} Aspenstrom P. (1997)
Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)^{1, 2, 3} Lee J.W....Moore D.D. (1995)
Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. (PubMed id 10713100)^{1, 2, 9} Tian L.... Stewart D.M. (2000)
Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. (PubMed id 12604778)^{1, 2, 9} Holbert S....Neri C. (2003)
Splicing variant of Cdc42 interacting protein-4 disrupts beta- catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma. (PubMed id 16343437)^{1, 2, 9} Tsuji E.... Saku K. (2006)
Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. (PubMed id 11069762)^{1, 2, 9} Linder S.... Aepfelbacher M. (2000)
Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. (PubMed id 17512409)^{1, 2, 9} Shimada A....Yokoyama S. (2007)
Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL. (PubMed id 16318909)^{1, 2, 9} Qian J....Janssen O. (2006)
Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. (PubMed id 11691828)^{1, 2, 9} Yuan R.-Q....Rosen E.M. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9322	HGNC: 12304	AceView: TRIP10	Ensembl:ENSG00000125733	euGenes: HUgn9322
ECgene: TRIP10	Kegg: 9322	H-InvDB: TRIP10

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TRIP10	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRIP10 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TRIP10 gene:
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GeneCards and IP:
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TRIP10 Gene

thyroid hormone receptor interactor 10

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TRIP10 Gene

thyroid hormone receptor interactor 10

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