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TRIP10 Gene

protein-coding   GIFtS: 60
GCID: GC19P006737

Thyroid Hormone Receptor Interactor 10

(Previous name: salt tolerator)
(Previous symbol: STOT)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Thyroid Hormone Receptor Interactor 101 2     STP2 3
STOT1 2 3     TRIP-102 3
Salt Tolerator1 2     TR-Interacting Protein 102 3
Protein Felic2 3     Cdc42-Interacting Protein1
Salt Tolerant Protein2 3     HSTP2
Thyroid Receptor-Interacting Protein 102 3     Cdc42-Interacting Protein 42
CIP42 3     hSTP3

External Ids:    HGNC: 123041   Entrez Gene: 93222   Ensembl: ENSG000001257337   OMIM: 6045045   UniProtKB: Q156423   

Export aliases for TRIP10 gene to outside databases

Previous GC identifers: GC19P006834 GC19P006679 GC19P006690 GC19P006502


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIP10 Gene:
TRIP10 (thyroid hormone receptor interactor 10) is a protein-coding gene. GO annotations related to this gene include lipid binding and identical protein binding. An important paralog of this gene is FNBP1L.

UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642
Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By
similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during
endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes
membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by
recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission
of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion
structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL

Gene Wiki entry for TRIP10 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIP10 gene promoter:
         PPAR-gamma1   AP-1   ATF-2   STAT3   PPAR-gamma2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIP10 promoter sequence
   Search Chromatin IP Primers for TRIP10

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIP10


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

TRIP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIP10 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P006737:  view genomic region     (about GC identifiers)

Start:
6,737,936 bp from pter      End:
6,751,537 bp from pter
Size:
13,602 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642 (See protein sequence)
Recommended Name: Cdc42-interacting protein 4  
Size: 601 amino acids; 68352 Da
Subunit: Interacts specifically with GTP-bound RHOQ. Interacts with DNM2 and PDE6G (By similarity). Homodimerizes,
the dimers can polymerize end-to-end to form filamentous structures. Interacts specifically with GTP-bound CDC42.
Interacts with AKAP9, ARHGAP17, DAAM1, DIAPH1, DIAPH2, DNM1, FASLG/FASL, GAPVD1, LYN, microtubules, SRC, WAS/WASP
and WASL/N-WASP. Interacts with the ligand binding domain of the thyroid receptor (TR) in the presence of thyroid
hormone. May interact with CTNNB1 and HD/HTT
3 PDB 3D structures from and Proteopedia for TRIP10:
2CT4 (3D)        2EFK (3D)        2KE4 (3D)    
Secondary accessions: B2R8A6 B7WP22 D6W645 O15184 Q53G22 Q5TZN1 Q6FI24 Q8NFL1 Q8TCY1 Q8TDX3
Q96RJ1
Alternative splicing: 5 isoforms:  Q15642-1   Q15642-2   Q15642-3   Q15642-4   Q15642-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIP10: NX_Q15642

Explore proteomics data for TRIP10 at MOPED

Post-translational modifications: 

  • Tyrosine phosphorylated. Also phosphorylated by PKA1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIP10 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001275891.1  NP_001275892.1  NP_004231.1  

    ENSEMBL proteins: 
     ENSP00000471203   ENSP00000320493   ENSP00000472580   ENSP00000320117   ENSP00000469360  
     ENSP00000471056  
    Reactome Protein details: Q15642

    TRIP10 Human Recombinant Protein Products:

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    Novus Biologicals TRIP10 Proteins
    Novus Biologicals TRIP10 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIP10

     
    Search eBioscience for Proteins for TRIP10 

     
    antibodies-online proteins for TRIP10 (6 products) 

     
    antibodies-online peptides for TRIP10

    TRIP10 Antibody Products:

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    antibodies-online antibodies for TRIP10 (38 products) 

    TRIP10 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TRIP10
    Cloud-Clone Corp. CLIAs for TRIP10
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    antibodies-online kits for TRIP10 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR001060 FCH_dom
     IPR001452 SH3_domain
     IPR028498 CIP4

    Graphical View of Domain Structure for InterPro Entry Q15642

    ProtoNet protein and cluster: Q15642

    2 Blocks protein domains:
    IPB001060 Cdc15/Fes/CIP4
    IPB001452 SH3 domain signature


    UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642
    Domain: The F-BAR domain binds the phospholipid membrane with its concave surface. The end-to-end polymerization
    of dimers of these domains provides a curved surface that fits best membranes with around 600 A diameter, and may
    drive tubulation
    Similarity: Belongs to the FNBP1 family
    Similarity: Contains 1 FCH domain
    Similarity: Contains 1 REM (Hr1) repeat
    Similarity: Contains 1 SH3 domain


    Find genes that share domains with TRIP10           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CIP4_HUMAN, Q15642
    Function: Required for translocation of GLUT4 to the plasma membrane in response to insulin signaling (By
    similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during
    endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes
    membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by
    recruiting WASL/N-WASP which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission
    of membrane tubules to form endocytic vesicles. Required for the formation of podosomes, actin-rich adhesion
    structures specific to monocyte-derived cells. May be required for the lysosomal retention of FASLG/FASL
    Induction: Induced by adriamycin treatment and this effect is counteracted by HGF/SF. Expression is reduced during
    differentiation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16318909
    GO:0008289lipid binding IEA--
    GO:0042802identical protein binding IPI17512409
         
    Find genes that share ontologies with TRIP10           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trip10):
     adipose tissue  hematopoietic system  homeostasis/metabolism  immune system 

    Find genes that share phenotypes with TRIP10           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Trip10tm1.1Geha for TRIP10

       genOway: Develop your customized and physiologically relevant rodent model for TRIP10

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIP10:
    hsa-mir-186-5p (MIRT021113), hsa-mir-130b-3p (MIRT020146), hsa-mir-615-3p (MIRT016147), hsa-mir-93-5p (MIRT028160)

    Block miRNA regulation of human, mouse, rat TRIP10 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIP10 (see all 28):
    hsa-miR-142-5p hsa-miR-657 hsa-miR-106a hsa-miR-15a hsa-miR-519a hsa-miR-124 hsa-miR-424 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTRIP10 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIP10

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TRIP10 (NM_004240)
    Sino Biological Human cDNA Clone for TRIP10
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIP10

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIP10 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIP10


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CIP4_HUMAN, Q15642: Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Lysosome. Golgi apparatus. Cell membrane.
    Cell projection, phagocytic cup. Note=Translocates to the plasma membrane in response to insulin stimulation, and
    this may require active RHOQ (By similarity). Localizes to cortical regions coincident with F-actin, to lysosomes
    and to sites of phagocytosis in macrophages. Also localizes to the Golgi, and this requires AKAP9
    CIP4_HUMAN, Q15642: Isoform 5: Cytoplasm, perinuclear region
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    golgi apparatus5
    lysosome5
    plasma membrane5
    vacuole5
    cytosol4
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001891phagocytic cup IEA--
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm NAS9210375
    GO:0005764lysosome IEA--

    Find genes that share ontologies with TRIP10           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIP10 About    
    See pathways by source

    SuperPathContained pathways About
    1Rho GTPase cycle
    Rho GTPase cycle1.00
    Signaling by Rho GTPases1.00
    2Signaling by GPCR
    Signal Transduction0.58
    3Translation Insulin regulation of translation
    Insulin signaling pathway0.32
    4Insulin Pathway
    Insulin Pathway
    5Insulin-mediated glucose transport
    Insulin-mediated glucose transport


    Find genes that share SuperPaths with TRIP10           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for TRIP10
        Insulin-mediated glucose transport
    Insulin Pathway


    1 Reactome Pathway for TRIP10
        Rho GTPase cycle


    1 Kegg Pathway  (Kegg details for TRIP10):
        Insulin signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIP10
    Interactions:

        GeneGlobe Interaction Network for TRIP10

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIP10 (Q156421, 2, 3 ENSP000003204934) via UniProtKB, MINT, STRING, and/or I2D (see all 111)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAAM1Q9Y4D11, 2, 3, ENSP000002471704EBI-6550597,EBI-2817289 MINT-7146205 MINT-7146069 I2D: score=1 STRING: ENSP00000247170
    WBP11Q9Y2W22, 3, ENSP000002611674MINT-66047 I2D: score=5 STRING: ENSP00000261167
    LYNP079482, 3MINT-50925 MINT-50926 I2D: score=2 
    FASLGP480231, 2, 3, ENSP000003566944EBI-739936,EBI-495538 MINT-7137078 MINT-7137256 MINT-7137027 MINT-7137245 I2D: score=1 STRING: ENSP00000356694
    CDC42P609532, 3, ENSP000003144584MINT-15379 MINT-50937 I2D: score=3 STRING: ENSP00000314458
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006897endocytosis IEA--
    GO:0007154cell communication NAS9210375
    GO:0007165signal transduction TAS9210375
    GO:0007264small GTPase mediated signal transduction TAS--
    GO:0030036actin cytoskeleton organization NAS9210375

    Find genes that share ontologies with TRIP10           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIP10 (CIP4)

    Selected HMDB Compounds for TRIP10 (see all 125)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--
    PS(14:0/14:0)Phosphatidylserine(14:0/14:0) (see all 7)----
    PS(14:0/14:1(9Z))Phosphatidylserine(14:0/14:1n5) (see all 13)----
    PS(14:0/16:0)1-myristoyl-2-palmitoyl-sn-glycero-3-phosphoserine (see all 7)----
    PS(14:0/16:1(9Z))PS(14:0/16:1n7) (see all 13)----
    PS(14:0/18:0)Phosphatidylserine(32:0) (see all 7)----
    PS(14:0/18:1(9Z))PSer(14:0/18:1n9) (see all 13)----
    PS(14:0/18:2(9Z,12Z))PS(14:0/18:2) (see all 13)----
    PS(14:0/18:3(9Z,12Z,15Z))Phosphatidylserine(14:0/18:3) (see all 14)----
    PS(14:0/20:3(8Z,11Z,14Z))PSer(14:0/20:3) (see all 14)----

    1 Novoseek inferred chemical compound relationship for TRIP10 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 18.1 1 9210375 (1)



    Find genes that share compounds with TRIP10           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIP10 gene (3 alternative transcripts): 
    NM_001288962.1  NM_001288963.1  NM_004240.3  

    Unigene Cluster for TRIP10:

    Thyroid hormone receptor interactor 10
    Hs.515094  [show with all ESTs]
    Unigene Representative Sequence: AF502289
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000600428 ENST00000596543 ENST00000313285(uc010dux.2 uc002mfr.3 uc010duy.3)
    ENST00000600677 ENST00000313244(uc002mfs.3) ENST00000595305 ENST00000596758
    ENST00000600491 ENST00000596078 ENST00000596673 ENST00000595319 ENST00000601303
    ENST00000598843
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIP10 (see all 28):
    hsa-miR-142-5p hsa-miR-657 hsa-miR-106a hsa-miR-15a hsa-miR-519a hsa-miR-124 hsa-miR-424 hsa-miR-93
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      QuantiFast Probe-based Assays in human, mouse, rat TRIP10

    Additional mRNA sequence: 

    AB007845.1 AB072596.1 AF380114.1 AF502289.1 AJ000414.1 AK223109.1 AK313296.1 AL832186.1 
    AY081141.1 BC013002.2 BT006698.1 BT020167.1 BT020171.1 CR536513.1 L40379.1 

    18 DOTS entries:

    DT.417800  DT.95110854  DT.100641702  DT.100811272  DT.91748254  DT.92066548  DT.97847643  DT.100811271 
    DT.100811274  DT.40115429  DT.91748261  DT.100811269  DT.121446398  DT.121446403  DT.91827005  DT.92016799 
    DT.95234610  DT.91914775 

    Selected AceView cDNA sequences (see all 302):

    BE878629 F31129 CK818979 BX473367 AA128148 BG117435 BX101395 BI766557 
    AA631986 BQ675251 AA618396 CK300029 BE743785 F35309 BX471159 BM680963 
    BM977998 CD674778 BM988799 CD672374 BM559073 BE618269 BG575020 BE047692 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIP10 (see all 12)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b ^
    SP1:                    -     -     -                                         -     -                                         -           -                     
    SP2:                    -     -     -                                         -     -                                         -     -     -                     
    SP3:                                                                          -     -                                         -     -     -                     
    SP4:                    -     -     -                                         -     -                                         -     -     -                     
    SP5:                                                                          -           -     -     -     -     -     -     -     -     -     -     -         

    ExUns: 15 ^ 16 ^ 17a · 17b · 17c · 17d · 17e · 17f
    SP1:              -                                 
    SP2:              -                                 
    SP3:                                                
    SP4:                                                
    SP5:              -                                 


    ECgene alternative splicing isoforms for TRIP10

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIP10 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTTACATCT
    TRIP10 Expression
    About this image

    TRIP10 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIP10 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515094

    UniProtKB/Swiss-Prot: CIP4_HUMAN, Q15642
    Tissue specificity: Expressed in brain, colon, heart, kidney, liver, lung, megakaryocyte, ovary, pancreas,
    peripheral blood lymphocytes, placenta, prostate, skeletal muscle, small intestine, spleen, testis, thymus and
    trachea

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIP10 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trip101 , 5 thyroid hormone receptor interactor 101, 5 82.11(n)1
    88.29(a)1
      17 (29.74 cM)5
    1066281  NM_001242390.11  NP_001229319.11 
     572494515 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc562922 similar to thyroid hormone receptor interactor 10 69.81(n)   393193  BC046053.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Cip46
    Cip4
    29(a)
    1 → many
    3L(4322491-4364102)
    worm
    (Caenorhabditis elegans)
    Secernentea toca-16
    toca-26
    Protein TOCA-1, isoform a (toca-1) mRNA, complete ...
    Protein TOCA-2, isoform b (toca-2) mRNA, complete ...
    24(a)
    19(a)
    many ↔ many
    many ↔ many
    X(1510518-1521487) WBGene00017298
    III(13755942-13759451) WBGene00010663


    ENSEMBL Gene Tree for TRIP10 (if available)
    TreeFam Gene Tree for TRIP10 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIP10 gene
    FNBP1L2  FNBP12  
    3 SIMAP similar genes for TRIP10 using alignment to 5 protein entries:     CIP4_HUMAN (see all proteins):
    STP    FNBP1    FNBP1L

    Find genes that share paralogs with TRIP10           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIP10 (see all 391)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23031091,2
    C,F--6739710(+) AGGGCT/GGCGGG 1 -- ut512Minor allele frequency- G:0.25NA 4
    rs1908704791,2
    --6739724(+) CGGGCA/GGCGGG 1 -- ut510--------
    rs2005166111,2
    --6739808(+) CCAATC/GGGCCC 1 -- int10--------
    rs3446331,2
    C,F--6739934(+) TCCGCT/CCTCTC 1 -- int17Minor allele frequency- C:0.32MN NA CSA WA EA 548
    rs1731741,2
    C,F--6740026(+) GGTTGC/AGAATG 1 -- int18Minor allele frequency- A:0.32NA WA CSA EA 368
    rs752693171,2
    C--6740167(+) AGGAGA/GGGGGA 1 -- int10--------
    rs104100211,2
    C,F,A,H--6740380(+) CCTCAG/ACCCTG 1 -- int19Minor allele frequency- A:0.12NS EA NA CSA WA 776
    rs1481829531,2
    --6740406(+) TCCCCC/TTATCC 1 -- int10--------
    rs1839350721,2
    --6740474(+) TGCAGC/TGGGGG 1 -- int10--------
    rs1889353191,2
    --6740769(+) CCTATA/GTCGGA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIP10 (6737936 - 6751537 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TRIP10:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv14e196CNV Duplication17116639
    nsv910940CNV Loss21882294
    nsv470120CNV Loss18288195
    nsv910941CNV Loss21882294
    dgv3703n71CNV Loss21882294
    nsv519827CNV Loss19592680
    nsv519561CNV Loss19592680
    nsv910942CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604504    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for TRIP10:
    Wiskott-Aldrich syndrome

    Find genes that share disorders with TRIP10           About GenesLikeMe

    1 Novoseek inferred disease relationship for TRIP10 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    wiskott-aldrich syndrome 77.4 4 17785506 (1), 12604778 (1)


    Export disorders for TRIP10 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIP10 gene, integrated from 10 sources (see all 60):
    (articles sorted by number of sources associating them with TRIP10)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of human salt-tolerant protein. (PubMed id 11294612)1, 2, 3, 9 Tsuji E. and Tsuji Y. (Genetica 2000)
    2. A Cdc42 target protein with homology to the non-kinase domain of FER has a potential role in regulating the actin cytoskeleton. (PubMed id 9210375)1, 2, 3, 9 Aspenstroem P. (Curr. Biol. 1997)
    3. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. (PubMed id 7776974)1, 2, 3 Lee J.W.... Moore D.D. (Mol. Endocrinol. 1995)
    4. Cdc42-interacting protein 4 mediates binding of the Wiskott-Aldrich syndrome protein to microtubules. (PubMed id 10713100)1, 2, 9 Tian L.... Stewart D.M. (J. Biol. Chem. 2000)
    5. Cdc42-interacting protein 4 binds to huntingtin: neuropathologic and biological evidence for a role in Huntington's disease. (PubMed id 12604778)1, 2, 9 Holbert S....Neri C. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    6. Splicing variant of Cdc42 interacting protein-4 disrupts beta- catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma. (PubMed id 16343437)1, 2, 9 Tsuji E.... Saku K. (Biochem. Biophys. Res. Commun. 2006)
    7. Microtubule-dependent formation of podosomal adhesion structures in primary human macrophages. (PubMed id 11069762)1, 2, 9 Linder S.... Aepfelbacher M. (J. Cell Sci. 2000)
    8. Curved EFC/F-BAR-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. (PubMed id 17512409)1, 2, 9 Shimada A.... Yokoyama S. (Cell 2007)
    9. Regulation of FasL expression: a SH3 domain containing protein family involved in the lysosomal association of FasL. (PubMed id 16318909)1, 2, 9 Qian J....Janssen O. (Cell. Signal. 2006)
    10. Altered gene expression pattern in cultured human breast cancer cells treated with hepatocyte growth factor/scatter factor in the setting of DNA damage. (PubMed id 11691828)1, 2, 9 Yuan R.-Q....Rosen E.M. (Cancer Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9322 HGNC: 12304 AceView: TRIP10 Ensembl:ENSG00000125733 euGenes: HUgn9322
    ECgene: TRIP10 Kegg: 9322 H-InvDB: TRIP10

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIP10 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIP10 gene:
    Search GeneIP for patents involving TRIP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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