Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TRIOBP Gene

protein-coding GIFtS: 55
GCID: GC22P038092

TRIO and F-actin binding protein

(Previous symbol: DFNB28)

Explore 5 diseases affiliated with
TRIOBP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
TRIO And F-Actin Binding Protein¹ ²		Tara¹
KIAA1662¹ ³ ⁵		DJ37E16.4¹
DFNB28¹ ²		Tara-Like Protein²
Protein Tara² ³		TRIO And F-Actin-Binding Protein²
Trio-Associated Repeat On Actin² ³		EC 3.6.3.14⁸
TARA² ³		EC 6.1.1.4⁸
HRIHFB2122¹		EC 6.3.5.5⁸

External Ids:	HGNC: 17009¹	Entrez Gene: 11078²	Ensembl: ENSG00000100106⁷	OMIM: 609761⁵	UniProtKB: Q9H2D6³

Export aliases for TRIOBP gene to outside databases

Previous GC identifers: GC22P036447 GC22P021064

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIOBP:

This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The

protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton

organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin

structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness.

Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene,

however some transcripts may be subject to nonsense-mediated decay (NMD). (provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6

Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and

stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin

present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and

turnover

Gene Wiki entry for TRIOBP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000022.10 NC_018933.1 NT_011520.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TRIOBP gene promoter:
c-Fos AP-1 Sp1 Pax-2 Pax-2a Nkx2-5 MIF-1 GATA-1 HEN1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIOBP promoter sequence

Search SABiosciences Chromatin IP Primers for TRIOBP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIOBP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1 Ensembl cytogenetic band: 22q13.1 HGNC cytogenetic band: 22q13.1

TRIOBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIOBP gene location

GeneLoc information about chromosome 22 GeneLoc Exon Structure

GeneLoc location for GC22P038092: view genomic region (about GC identifiers)

Start:	38,092,995 bp from pter	End:	38,172,563 bp from pter
Size:	79,569 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6 (See protein sequence)

Recommended Name: TRIO and F-actin-binding protein

Size: 2365 amino acids; 261376 Da

Subunit: Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3

Subcellular location: Nucleus. Cytoplasm, cytoskeleton. Note=Localized to F-actin in a periodic pattern

Miscellaneous: Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted protein

Sequence caution: Sequence=BAA34800.1; Type=Frameshift; Positions=478;

Secondary accessions: B1AHD4 B1AHD7 O94797 Q2PZW8 Q2Q3Z9 Q2Q400 Q5R3M6 Q96DW1 Q9BT77 Q9BTL7 Q9BY98

Q9Y3L4

Alternative splicing: 5 isoforms: Q9H2D6-1 Q9H2D6-2 Q9H2D6-3 Q9H2D6-4 Q9H2D6-5

Explore the universe of human proteins at neXtProt for TRIOBP: NX_Q9H2D6

Post-translational modifications:

Ubiquitinated by HECTD3, leading to its degradation by the proteasome¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9H2D6

3 DME Specific Peptides for TRIOBP (Q9H2D6)

IEKKWQE

NPRASRT

RVPLTAL

TRIOBP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001034230.1 NP_008963.3 NP_619538.2

ENSEMBL proteins:

ENSP00000384312 ENSP00000340312 ENSP00000383913 ENSP00000386026 ENSP00000399006

ENSP00000400680 ENSP00000396946 ENSP00000407542 ENSP00000387881

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: TRIOBP OriGene Custom Protein Services for TRIOBP
	GenScript Custom Purified and Recombinant Proteins Services for TRIOBP
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for TRIOBP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IDA	--
GO:0015629	actin cytoskeleton	NAS	11148140

TRIOBP for ontologies About GeneDecksing

TRIOBP Antibody Products:

	Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse R&D Systems for Antibodies
	OriGene Antibodies: TRIOBP OriGene Custom Antibody Services for TRIOBP
	GenScript Custom Superior Antibodies Services for TRIOBP
	Novus Biologicals TRIOBP Antibodies
	Search for Antibodies for TRIOBP at Abcam
	Uscn Antibodies for TRIOBP
	ThermoFisher Antibodies for TRIOBP

Assay Products for TRIOBP:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for TRIOBP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for TRIOBP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TRIOBP for domains About GeneDecksing

2 InterPro domains/families:

IPR001849 Pleckstrin_homology

IPR011993 PH_like_dom

Graphical View of Domain Structure for InterPro Entry Q9H2D6

ProtoNet protein and cluster: Q9H2D6

1 Blocks protein family: IPB001849 Pleckstrin-like

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6

Domain: Contains at least 2 actin-binding sites per coiled-coil dimer

Similarity: Contains 1 PH domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6

Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding and

stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of F-actin

present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin formation and

turnover

Enzyme Numbers (IUBMB): EC 6.1.1.4² EC 3.6.3.14² EC 6.3.5.5²

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TRIOBP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIOBP
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIOBP (see all 57):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-100* hsa-miR-642a hsa-let-7d hsa-miR-106a hsa-miR-374a hsa-miR-650

		SwitchGear 3'UTR luciferase reporter plasmid: TRIOBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIOBP (see all 4) OriGene shRNA RFP: TRIOBP OriGene siRNA: TRIOBP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIOBP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for TRIOBP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TRIOBP (NM_007032)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIOBP
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIOBP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TRIOBP
		Search LifeMap BioReagents cell lines for TRIOBP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIOBP

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	--	--
GO:0005543	phospholipid binding	IEA	--
GO:0017049	GTP-Rho binding	NAS	11148140
GO:0031625	ubiquitin protein ligase binding	IPI	18194665
GO:0045159	myosin II binding	NAS	11148140

TRIOBP for ontologies About GeneDecksing

1 GenomeRNAi human phenotype for TRIOBP:

Increased gamma-H2AX phosphory

Animal Models:
3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Triobp):

hearing/vestibular/ear

mortality/aging

nervous system

TRIOBP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for TRIOBP

STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

5/11 Interacting proteins for TRIOBP (Q9H2D6^{2, 3} ENSP00000384312⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VIM	P08670²^,³, ENSP00000224237⁴	MINT-65490 I2D: score=5 STRING: ENSP00000224237
HECTD3	Q5T447³, ENSP00000361245⁴	I2D: score=1 STRING: ENSP00000361245
UBC	P0CG48³, ENSP00000344818⁴	I2D: score=1 STRING: ENSP00000344818
APC	P25054³	I2D: score=2
PLK1	ENSP00000300093⁴	STRING: ENSP00000300093

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030047	actin modification	NAS	11148140
GO:0051016	barbed-end actin filament capping	NAS	11148140
GO:1900026	positive regulation of substrate adhesion-dependent cell spreading	IDA	11148140

TRIOBP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIOBP
Search CenterWatch for drugs/clinical trials and news about TRIOBP / TARA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIOBP gene (3 alternative transcripts):

NM_001039141.2 NM_007032.5 NM_138632.2

Unigene Cluster for TRIOBP:

TRIO and F-actin binding protein

Hs.533030 [show with all ESTs]

Unigene Representative Sequence: NM_001039141

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000406386(uc003atr.3 uc003atu.3 uc003atw.3 uc010gxh.3)

ENST00000492485(uc003ats.1) ENST00000344404 ENST00000407319(uc003atv.3)

ENST00000403663(uc003atx.1) ENST00000428075 ENST00000413051 ENST00000418339

ENST00000452519 ENST00000417857 ENST00000331103

miRNA Products:		OriGene 3'-UTR Clone (see all 3): TRIOBP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIOBP
		8/57 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIOBP (see all 57):
		hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-100* hsa-miR-642a hsa-let-7d hsa-miR-106a hsa-miR-374a hsa-miR-650

		SwitchGear 3'UTR luciferase reporter plasmid: TRIOBP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIOBP (see all 4) OriGene shRNA RFP: TRIOBP OriGene siRNA: TRIOBP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIOBP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP (see all 7) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP (see all 5) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): TRIOBP (NM_007032)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIOBP
		Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIOBP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIOBP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRIOBP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIOBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIOBP

Additional cDNA sequence:

AB015343.1 AF281030.1 AK096634.2 BC003618.2 BC004303.1 BC013278.2 BC022200.1 DQ228005.1

24/27 DOTS entries (see all 27):

DT.99952146 DT.92405379 DT.87016385 DT.91770761 DT.100039197 DT.97854934 DT.40232095 DT.120660805

DT.95223749 DT.120660817 DT.91770760 DT.100825516 DT.95223754 DT.100825523 DT.95123996 DT.95135832

DT.120660912 DT.92024993 DT.97805516 DT.99952613 DT.100039198 DT.100806261 DT.100825522 DT.120660827

24/490 AceView cDNA sequences (see all 490):

AI160225 BM555885 BM550420 T34766 BG150364 CD245693 CK725202 BM928773

CR621354 AA976017 BE159415 BQ711287 BM556850 BE280606 BU501200 BU557896

AI653268 BQ671535 BQ423196 BQ961700 BQ675894 BQ653762 BU849787 BQ673866

GeneLoc Exon Structure

5/13 Alternative Splicing Database (ASD) splice patterns (SP) for TRIOBP (see all 13) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	^	11	^	12a	·	12b	·	12c	^	13a	·	13b	·	13c	·	13d	^	14a	·	14b	^	15	^	16	^
SP1:													-		-		-		-		-
SP2:															-		-		-		-
SP3:
SP4:
SP5:											-		-		-		-		-		-

ExUns:	17	^	18	^	19	^	20a	·	20b	^	21a	·	21b	·	21c	·	21d	^	22a	·	22b
SP1:							-								-		-
SP2:							-								-		-
SP3:															-		-
SP4:							-
SP5:

ECgene alternative splicing isoforms for TRIOBP

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIOBP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TACACACGGA

About this image
See TRIOBP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIOBP

SOURCE GeneReport for Unigene cluster: Hs.533030

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6

Tissue specificity: Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal brain,

retina and cochlea but is not detectable in the other tissues

SABiosciences Custom PCR Arrays for TRIOBP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIOBP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TRIOBP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIOBP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIOBP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIOBP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for TRIOBP gene from 7/16 species (see all 16) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Triobp^{1 , 5}	TRIO and F-actin binding protein^{1, 5}	75.79(n)¹ 71.41(a)¹		15 (37.70 cM)⁵ 110253¹ NM_001039156.1¹ NP_001034245.1¹ 78947724⁵
chicken (Gallus gallus)	Aves	LOC100859397¹	TRIO and F-actin-binding protein-like	74.07(n) 72.22(a)		100859397 XM_003643877.1 XP_003643925.1
lizard (Anolis carolinensis)	Reptilia	TRIOBP⁶	--	69(a)	1 ↔ 1	5(23959588-23976670)
African clawed frog (Xenopus laevis)	Amphibia	Xl.12480²	Xenopus laevis transcribed sequence with weak similarity more	73.57(n)		BU908154.1
zebrafish (Danio rerio)	Actinopterygii	triobp⁶ si:ch211-133l11.8⁶	si:ch211-133l11.8	38(a) 26(a)	many → 1 many → 1	3(1940165-1953609) 1(54603831-54630281)
fruit fly (Drosophila melanogaster)	Insecta	osp⁶	outspread	12(a)	1 → many	2L(14599776-14689325)
worm (Caenorhabditis elegans)	Secernentea	F10G8.8⁶	--	15(a)	1 → many	I(10050682-10062017)

ENSEMBL Gene Tree for TRIOBP (if available)
TreeFam Gene Tree for TRIOBP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TRIOBP gene

MPRIP²

3 SIMAP similar genes for TRIOBP using alignment to 9 protein entries: TARA_HUMAN (see all proteins):

DKFZp547M048 MPRIP M-RIP

TRIOBP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 22 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs79945262^1,2	C,F,	other	21087269(+)	`TGTGCC/ACAGCG`	2	/A	syn¹		2		WA EU	1279
rs58432924^1,2	C,	--	21058053(+)	`CTGGCC/TAACAC`	1	--	us2k¹		1		WA	2
rs5750475^1,2	H	--	21058423(+)	`CTGTGC/TTAGTA`	1	--	us2k¹		4		NS EA	420
rs10427959^1,2	C,F,H,	--	21058680(+)	`CTGGTG/TAGGGG`	1	--	us2k¹		7		NS EA WA CSA	541
rs11913932^1,2	C,F,H,	--	21058705(+)	`GAGCTT/GGGAGA`	1	--	us2k¹		6		NS EA WA	538
rs114240160^1,2	C,F,	--	21059088(+)	`CAACAA/GCTCTC`	1	--	us2k¹		1		WA	118
rs9622683^1,2	C,H	--	21059102(+)	`ATAATC/TTAAGA`	1	--	us2k¹		5		NS EA NA	422
rs1004890^1,2	C,F,A,H,	--	21059824(+)	`CCTCCG/ACCCCG`	1	--	us2k¹		4		NA EA	244
rs75186179^1,2		--	21059958(+)	`TTCATG/TGTTAA`	1	--	ut5¹		0	--	--	--	--
rs78630536^1,2	F,	--	21060095(+)	`TCGAGG/AGATCC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for TRIOBP (38092995 - 38172563 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for TRIOBP
1 CNV: 4128
9 Indels: 33362 91062 27052 91061 33726 91060 79575 33725 79574
Human Gene Mutation Database (HGMD): TRIOBP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIOBP

DNA2.0 Custom Variant and Variant Library Synthesis for TRIOBP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TRIOBP for disorders           About GeneDecksing

OMIM gene information: 609761
OMIM disorders: 609823
UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6

Defects in TRIOBP are the cause of deafness autosomal recessive type 28 (DFNB28) [MIM:609823]

5 diseases for TRIOBP: About MalaCards

nonsyndromic deafness deafness, autosomal recessive 28 autosomal recessive nonsyndromic deafness hearing loss

usher syndrome

1 disease from the University of Copenhagen DISEASES database for TRIOBP:

Nonsyndromic deafness

Human Genome Epidemiology (HuGE) Navigator: TRIOBP (3 documents)

Export disorders for TRIOBP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TRIOBP gene, integrated from 9 sources (see all 32):
(articles sorted by number of sources associating them with TRIOBP)

Utopia: connect your pdf to the dynamic
world of online information

Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. (PubMed id 16385457)^{1, 2, 3, 9} Riazuddin S....Friedman T.B. (2006)
Mutations in a novel isoform of TRIOBP that encodes a filamentous- actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. (PubMed id 16385458)^{1, 2, 3} Shahin H.... Kanaan M. (2006)
Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. (PubMed id 11148140)^{1, 2, 3} Seipel K.... Streuli M. (2001)
The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PubMed id 18194665)^{1, 2} Yu J....Huang H. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{1, 2} Nakajima D.... Nagase T. (2002)
Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)^{1, 2} Hirosawa M....Ohara O. (2001)
The DNA sequence of human chromosome 22. (PubMed id 10591208)^{1, 2} Dunham I....O'Brien K.P. (1999)
Selection system for genes encoding nuclear-targeted proteins. (PubMed id 9853615)^{1, 2} Ueki N.... Muramatsu M.-A. (1998)
Phosphorylation of Tara by Plk1 is essential for faith ful chromosome segregation in mitosis. (PubMed id 22820163)¹ Zhu Y....Huang H. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 11078	HGNC: 17009	AceView: HRIHFB2122	Ensembl:ENSG00000100106	euGenes: HUgn11078
ECgene: TRIOBP	H-InvDB: TRIOBP

(According to HUGE)
About This Section

HUGE: KIAA1662

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TRIOBP	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TRIOBP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TRIOBP gene:
Search GeneIP for patents involving TRIOBP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for TRIOBP		OriGene shRNA RFP for TRIOBP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIOBP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIOBP
	OriGene Protein Over-expression Lysate for TRIOBP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for TRIOBP		OriGene 3'-UTR Clone for TRIOBP
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIOBP
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for TRIOBP		OriGene Custom Protein Services for TRIOBP
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIOBP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIOBP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIOBP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIOBP
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIOBP
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIOBP

	GenScript Custom Purified and Recombinant Proteins Services for TRIOBP		GenScript cDNA clones with any tag delivered in your preferred vector for TRIOBP
	GenScript Custom Assay Services for TRIOBP		GenScript Custom Superior Antibodies Services for TRIOBP
	GenScript Custom overexpressing Cell Line Services for TRIOBP		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in TRIOBP promoter
	Search Chromatin IP Primers for TRIOBP
	RT² qPCR Primer Assay in human, mouse, rat TRIOBP
	GNC Network for TRIOBP
	SABiosciences Custom PCR Arrays for TRIOBP

Search Tocris compounds for TRIOBP

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	TRIOBP antibodies

	Search for Antibodies for TRIOBP at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for TRIOBP
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

TRIOBP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for TRIOBP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIOBP

	SwitchGear 3'UTR luciferase reporter plasmids for TRIOBP
	SwitchGear Promoter luciferase reporter plasmids for TRIOBP

ThermoFisher Antibodies for TRIOBP

Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIOBP

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes TRIOBP gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

TRIOBP Gene

TRIO and F-actin binding protein

Aliases
for TRIOBP gene

Summaries
for TRIOBP gene

Genomic Views
for TRIOBP gene

Proteins
for TRIOBP gene

Protein Domains /
Families
for TRIOBP gene

Function
for TRIOBP gene

Pathways & Interactions
for TRIOBP gene

Drugs & Compounds
for TRIOBP gene

Transcripts
for TRIOBP gene

Expression
for TRIOBP gene

Orthologs
for TRIOBP gene

Paralogs
for TRIOBP gene

Genomic Variants
for TRIOBP gene

Disorders / Diseases
for TRIOBP gene

Publications
for TRIOBP gene

External Searches for TRIOBP gene

Genome Databases showing TRIOBP gene

Other Databases showing TRIOBP gene

Specialized Databases showing TRIOBP gene

Intellectual Property
for TRIOBP gene

Products
for TRIOBP gene

View Random Gene

Advanced Search

Export list of displayed genes

TRIOBP Gene

TRIO and F-actin binding protein

Aliasesfor TRIOBP gene

Summariesfor TRIOBP gene

Genomic Viewsfor TRIOBP gene

Proteinsfor TRIOBP gene

Protein Domains /Familiesfor TRIOBP gene

Functionfor TRIOBP gene

Pathways & Interactionsfor TRIOBP gene

Drugs & Compoundsfor TRIOBP gene

Transcriptsfor TRIOBP gene

Expression for TRIOBP gene

Orthologsfor TRIOBP gene

Paralogsfor TRIOBP gene

Genomic Variantsfor TRIOBP gene

Disorders / Diseasesfor TRIOBP gene

Publicationsfor TRIOBP gene

External Searches for TRIOBP gene

Genome Databases showing TRIOBP gene

Other Databases showing TRIOBP gene

Specialized Databases showing TRIOBP gene

Intellectual Propertyfor TRIOBP gene

Productsfor TRIOBP gene

View Random Gene

Aliases
for TRIOBP gene

Summaries
for TRIOBP gene

Genomic Views
for TRIOBP gene

Proteins
for TRIOBP gene

Protein Domains /
Families
for TRIOBP gene

Function
for TRIOBP gene

Pathways & Interactions
for TRIOBP gene

Drugs & Compounds
for TRIOBP gene

Transcripts
for TRIOBP gene

Expression
for TRIOBP gene

Orthologs
for TRIOBP gene

Paralogs
for TRIOBP gene

Genomic Variants
for TRIOBP gene

Disorders / Diseases
for TRIOBP gene

Publications
for TRIOBP gene

Intellectual Property
for TRIOBP gene

Products
for TRIOBP gene