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TRIOBP Gene

protein-coding   GIFtS: 58
GCID: GC22P038092

TRIO And F-Actin Binding Protein


(Previous symbol: DFNB28)
  See TRIOBP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRIO And F-Actin Binding Protein1 2     dJ37E16.42
DFNB281 2     Tara-Like Protein2
Protein Tara2 3     TRIO And F-Actin-Binding Protein2
Trio-Associated Repeat On Actin2 3     EC 3.6.3.148
TARA2 3     EC 6.1.1.48
KIAA16623 5     EC 6.3.5.58

External Ids:    HGNC: 170091   Entrez Gene: 110782   Ensembl: ENSG000001001067   OMIM: 6097615   UniProtKB: Q9H2D63   

Export aliases for TRIOBP gene to outside databases

Previous GC identifers: GC22P036447 GC22P021064


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIOBP Gene:
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The
protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton
organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin
structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness.
Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this
gene, however some transcripts may be subject to nonsense-mediated decay (NMD). (provided by RefSeq, Nov 2008)

GeneCards Summary for TRIOBP Gene:
TRIOBP (TRIO and F-actin binding protein) is a protein-coding gene. Diseases associated with TRIOBP include deafness, autosomal recessive 28, and dfnb28 nonsyndromic hearing loss and deafness. GO annotations related to this gene include phospholipid binding and actin filament binding. An important paralog of this gene is MPRIP.

UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6
Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding
and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of
F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin
formation and turnover

Gene Wiki entry for TRIOBP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000022.10  NC_018933.2  NT_011520.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIOBP gene promoter:
         c-Fos   AP-1   Sp1   Pax-2   Pax-2a   Nkx2-5   MIF-1   GATA-1   HEN1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIOBP promoter sequence
   Search Chromatin IP Primers for TRIOBP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIOBP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q13.1   Ensembl cytogenetic band:  22q13.1   HGNC cytogenetic band: 22q13.1

TRIOBP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIOBP gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P038092:  view genomic region     (about GC identifiers)

Start:
38,092,995 bp from pter      End:
38,172,563 bp from pter
Size:
79,569 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6 (See protein sequence)
Recommended Name: TRIO and F-actin-binding protein  
Size: 2365 amino acids; 261376 Da
Subunit: Binds to TRIO and F-actin. May also interact with myosin II. Interacts with HECTD3
Miscellaneous: Has been identified in PubMed:9853615 by a selection system for genes encoding nuclear-targeted
protein
Sequence caution: Sequence=BAA34800.1; Type=Frameshift; Positions=478;
Secondary accessions: B1AHD4 B1AHD7 F2Z2W0 O94797 Q2PZW8 Q2Q3Z9 Q2Q400 Q5R3M6 Q96DW1 Q9BT77
Q9BTL7 Q9BY98 Q9Y3L4
Alternative splicing: 6 isoforms:  Q9H2D6-1   Q9H2D6-2   Q9H2D6-3   Q9H2D6-4   Q9H2D6-5   Q9H2D6-6   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIOBP: NX_Q9H2D6

Explore proteomics data for TRIOBP at MOPED

Post-translational modifications: 

  • Ubiquitinated by HECTD3, leading to its degradation by the proteasome1
  • Isoform 1: Phosphorylation at Thr-457 by PLK1 ensures mitotic progression and is essential for accurate chromosome
    segregation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • 3 DME Specific Peptides for TRIOBP (Q9H2D6)
     IEKKWQE  NPRASRT  RVPLTAL 


    See TRIOBP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001034230.1  NP_008963.3  NP_619538.2  

    ENSEMBL proteins: 
     ENSP00000384312   ENSP00000340312   ENSP00000383913   ENSP00000386026   ENSP00000399006  
     ENSP00000400680   ENSP00000396946   ENSP00000407542   ENSP00000387881  

    TRIOBP Human Recombinant Protein Products:

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    TRIOBP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Search eBioscience for ELISAs for TRIOBP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    PLEKH: Pleckstrin homology (PH) domain containing

    2 InterPro protein domains:
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom

    Graphical View of Domain Structure for InterPro Entry Q9H2D6

    ProtoNet protein and cluster: Q9H2D6

    1 Blocks protein domain: IPB001849 Pleckstrin-like

    UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6
    Domain: Contains at least 2 actin-binding sites per coiled-coil dimer
    Similarity: Contains 1 PH domain


    Find genes that share domains with TRIOBP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TARA_HUMAN, Q9H2D6
    Function: May regulate actin cytoskeletal organization, cell spreading and cell contraction by directly binding
    and stabilizing filamentous F-actin. The localized formation of TARA and TRIO complexes coordinates the amount of
    F-actin present in stress fibers. May also serve as a linker protein to recruit proteins required for F-actin
    formation and turnover

         Enzyme Numbers (IUBMB): EC 6.1.1.42 EC 3.6.3.142 EC 6.3.5.52

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0017049GTP-Rho binding NAS11148140
    GO:0031625ubiquitin protein ligase binding IPI18194665
    GO:0045159myosin II binding NAS11148140
    GO:0051015actin filament binding IDA11148140
         
    Find genes that share ontologies with TRIOBP           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIOBP:
     Increased gamma-H2AX phosphory 

         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Triobp):
     hearing/vestibular/ear  mortality/aging  nervous system 

    Find genes that share phenotypes with TRIOBP           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIOBP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIOBP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIOBP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIOBP

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIOBP:
    hsa-mir-26b-5p (MIRT029872)

    Block miRNA regulation of human, mouse, rat TRIOBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIOBP (see all 57):
    hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-100* hsa-miR-642a hsa-let-7d hsa-miR-106a hsa-miR-374a hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidTRIOBP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIOBP
    Predesigned siRNA for gene silencing in human, mouse, rat TRIOBP

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 3): TRIOBP (NM_007032)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIOBP
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIOBP

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIOBP 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIOBP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TARA_HUMAN, Q9H2D6: Nucleus. Cytoplasm, cytoskeleton. Note=Localized to F-actin in a periodic pattern
    TARA_HUMAN, Q9H2D6: Isoform 1: Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.
    Midbody. Note=Centrosomal localization occurs upon phosphorylation by PLK1 at Thr-457 and lasts from prophase to
    anaphase. At telophase, relocalizes to midbody
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0005815microtubule organizing center IEA--
    GO:0015629actin cytoskeleton NAS11148140
    GO:0030496midbody IEA--

    Find genes that share ontologies with TRIOBP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIOBP
    Interactions:

        GeneGlobe Interaction Network for TRIOBP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRIOBP (Q9H2D62, 3 ENSP000003843124) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    VIMP086702, 3, ENSP000002242374MINT-65490 I2D: score=5 STRING: ENSP00000224237
    HECTD3Q5T4473, ENSP000003612454I2D: score=1 STRING: ENSP00000361245
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    APCP250543I2D: score=2 
    PLK1ENSP000003000934STRING: ENSP00000300093
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0030047actin modification NAS11148140
    GO:0051016barbed-end actin filament capping NAS11148140
    GO:1900026positive regulation of substrate adhesion-dependent cell spreading IDA11148140

    Find genes that share ontologies with TRIOBP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIOBP (TARA)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIOBP gene (3 alternative transcripts): 
    NM_001039141.2  NM_007032.5  NM_138632.2  

    Unigene Cluster for TRIOBP:

    TRIO and F-actin binding protein
    Hs.533030  [show with all ESTs]
    Unigene Representative Sequence: NM_001039141
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000406386(uc003atr.3 uc003atu.3 uc003atw.3 uc010gxh.3)
    ENST00000492485(uc003ats.1) ENST00000344404 ENST00000407319(uc003atv.3)
    ENST00000403663(uc003atx.1) ENST00000428075 ENST00000413051 ENST00000418339
    ENST00000452519 ENST00000417857 ENST00000331103
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIOBP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIOBP (see all 57):
    hsa-miR-142-5p hsa-miR-3130-5p hsa-miR-100* hsa-miR-642a hsa-let-7d hsa-miR-106a hsa-miR-374a hsa-miR-650
    SwitchGear 3'UTR luciferase reporter plasmidTRIOBP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIOBP
    Predesigned siRNA for gene silencing in human, mouse, rat TRIOBP
    Clone
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    OriGene ORF clones in mouse, rat for TRIOBP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): TRIOBP (NM_007032)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIOBP
    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIOBP
    Primer
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    OriGene qPCR primer pairs and template standards for TRIOBP
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIOBP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIOBP
      QuantiTect SYBR Green Assays in human, mouse, rat TRIOBP
      QuantiFast Probe-based Assays in human, mouse, rat TRIOBP

    Additional mRNA sequence: 

    AB015343.1 AF281030.1 AK096634.2 BC003618.2 BC004303.1 BC013278.2 BC022200.1 DQ228005.1 

    Selected DOTS entries (see all 27):

    DT.99952146  DT.92405379  DT.87016385  DT.91770761  DT.100039197  DT.97854934  DT.40232095  DT.120660805 
    DT.95223749  DT.120660817  DT.91770760  DT.100825516  DT.95223754  DT.100825523  DT.95123996  DT.95135832 
    DT.120660912  DT.92024993  DT.97805516  DT.99952613  DT.100039198  DT.100806261  DT.100825522  DT.120660827 

    Selected AceView cDNA sequences (see all 490):

    BM808230 BG150364 T34766 BM928773 CD245693 CK725202 CR621354 BF001585 
    BU168088 NM_007032 AA976017 BE159415 BQ711287 BM556850 BU501200 BE280606 
    BQ671535 BQ423196 AI653268 BU557896 BQ961700 BQ653762 BQ675894 BU849787 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIOBP (see all 13)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13a · 13b · 13c · 13d ^ 14a · 14b ^ 15 ^ 16 ^
    SP1:                                      -     -     -     -     -                                                                                             
    SP2:                                            -     -     -     -                                                                                             
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                -     -     -     -     -     -                                                                                             

    ExUns: 17 ^ 18 ^ 19 ^ 20a · 20b ^ 21a · 21b · 21c · 21d ^ 22a · 22b
    SP1:                    -                       -     -               
    SP2:                    -                       -     -               
    SP3:                                            -     -               
    SP4:                    -                                             
    SP5:                                                                  


    ECgene alternative splicing isoforms for TRIOBP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TRIOBP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TACACACGGA
    TRIOBP Expression
    About this image


    TRIOBP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    TRIOBP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIOBP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.533030

    UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6
    Tissue specificity: Widely expressed. Highly expressed in heart and placenta. Isoform 3 is expressed in fetal
    brain, retina and cochlea but is not detectable in the other tissues

        Custom PCR Arrays for TRIOBP
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    QuantiFast Probe-based Assays in human, mouse, rat TRIOBP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIOBP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIOBP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Triobp1 , 5 TRIO and F-actin binding protein1, 5 79.69(n)1
    76.25(a)1
      15 (37.70 cM)5
    1102531  NM_001039156.11  NP_001034245.11 
     789477245 
    chicken
    (Gallus gallus)
    Aves LOC1008593971 TRIO and F-actin-binding protein-like 74.98(n)
    73.06(a)
      100859397  XM_003643877.2  XP_003643925.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIOBP6
    TRIO and F-actin binding protein
    63(a)
    1 ↔ 1
    5(23890902-23979126)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.124802 Xenopus laevis transcribed sequence with weak similarity more 73.57(n)    BU908154.1 
    zebrafish
    (Danio rerio)
    Actinopterygii triobp6
    TRIOBP (2 of 2)6
    TRIO and F-actin binding protein
    39(a)
    24(a)
    many → 1
    many → 1
    3(1940165-1953609) ENSDARG00000006385
    1(54603831-54628866) ENSDARG00000075870
    fruit fly
    (Drosophila melanogaster)
    Insecta osp6
    outspread
    12(a)
    1 → many
    2L(14599776-14689325)
    worm
    (Caenorhabditis elegans)
    Secernentea F10G8.86
    Protein F10G8.8, isoform b
    13(a)
    1 → many
    I(10050693-10062028) WBGene00008666


    ENSEMBL Gene Tree for TRIOBP (if available)
    TreeFam Gene Tree for TRIOBP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIOBP gene
    MPRIP2  
    3 SIMAP similar genes for TRIOBP using alignment to 8 protein entries:     TARA_HUMAN (see all proteins):
    DKFZp547M048    MPRIP    M-RIP

    Find genes that share paralogs with TRIOBP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIOBP (see all 2121)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 22 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0257194
    Deafness, autosomal recessive, 28 (DFNB28)4--see VAR_0257192 G R mis40--------
    rs1182040291,2
    Cpathogenic122037898(+) CCACAC/TGAGAC 2 R * stg10--------
    rs799452621,2
    C,Funtested122037276(+) TGTGCC/ACAGCG 2 /A syn12Minor allele frequency- A:0.03WA EU 1279
    rs72895751,2
    C,A--21074604(+) aaaaaC/Aaaaaa 1 -- int1 trp31Minor allele frequency- A:0.50NA 2
    rs1139814571,2
    C,F--21075632(+) CGCCCG/AGCCTA 1 -- int13Minor allele frequency- A:0.25CSA WA NA 239
    rs3676870041,2
    C--21082973(+) TCATC-/ACACTGCACTC
    ACTGTTTCACTCAT
    CCCCC
    1 -- int10--------
    rs556510371,2
    C--21082974(+) TCATCC/ACCCCC 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs711950491,2
    C--21095689(+) AAAAA-/A/AA  
            
    GACAC
    1 -- int11NA 2
    rs1827617231,2
    C--21109237(+) CGCCGC/TCCCGC 3 -- us2k1 int10--------
    rs1139101331,2
    C,F--21109268(+) GTTGCG/CGCAGG 3 -- us2k1 int11Minor allele frequency- C:0.50NA 2

    HapMap Linkage Disequilibrium report for TRIOBP (38092995 - 38172563 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRIOBP (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2724218CNV Deletion23290073
    esv2658988CNV Deletion23128226
    esv1471410CNV Deletion17803354
    esv2660524CNV Deletion23128226
    esv2724219CNV Deletion23290073
    nsv829203CNV Loss20364138
    nsv834191CNV Loss17160897
    nsv471197CNV Loss18288195
    dgv4966n71CNV Loss21882294
    nsv915035CNV Loss21882294

    Human Gene Mutation Database (HGMD): TRIOBP
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIOBP
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIOBP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609761   
    OMIM disorders: 609823  
    UniProtKB/Swiss-Prot: TARA_HUMAN, Q9H2D6
  • Deafness, autosomal recessive, 28 (DFNB28) [MIM:609823]: A form of non-syndromic sensorineural hearing
    loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to
    the brain, or the area of the brain that receives sound information. Note=The disease is caused by mutations
    affecting the gene represented in this entry

  • 5 diseases for TRIOBP:    
    About MalaCards
    deafness, autosomal recessive 28    dfnb28 nonsyndromic hearing loss and deafness    deafness, autosomal recessive 76    nonsyndromic deafness
    autosomal recessive nonsyndromic deafness

    1 disease from the University of Copenhagen DISEASES database for TRIOBP:
    Nonsyndromic deafness

    Find genes that share disorders with TRIOBP           About GenesLikeMe

    Genetic Association Database (GAD): TRIOBP
    Human Genome Epidemiology (HuGE) Navigator: TRIOBP (3 documents)

    Export disorders for TRIOBP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIOBP gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with TRIOBP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutations in TRIOBP, which encodes a putative cytoskeletal-organizing protein, are associated with nonsyndromic recessive deafness. (PubMed id 16385457)1, 2, 3, 9 Riazuddin S....Friedman T.B. (Am. J. Hum. Genet. 2006)
    2. Mutations in a novel isoform of TRIOBP that encodes a filamentous- actin binding protein are responsible for DFNB28 recessive nonsyndromic hearing loss. (PubMed id 16385458)1, 2, 3 Shahin H.... Kanaan M. (Am. J. Hum. Genet. 2006)
    3. Tara, a novel F-actin binding protein, associates with the Trio guanine nucleotide exchange factor and regulates actin cytoskeletal organization. (PubMed id 11148140)1, 2, 3 Seipel K.... Streuli M. (J. Cell Sci. 2001)
    4. Phosphorylation of Tara by Plk1 is essential for faithful chromosome segregation in mitosis. (PubMed id 22820163)1, 2 Zhu Y.... Huang H. (Exp. Cell Res. 2012)
    5. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    6. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. (PubMed id 18194665)1, 2 Yu J.... Huang H. (Biochem. Biophys. Res. Commun. 2008)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    9. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. (PubMed id 11258795)1, 2 Hirosawa M.... Ohara O. (DNA Res. 2001)
    10. The DNA sequence of human chromosome 22. (PubMed id 10591208)1, 2 Dunham I.... Wright H. (Nature 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 11078 HGNC: 17009 AceView: HRIHFB2122 Ensembl:ENSG00000100106 euGenes: HUgn11078
    ECgene: TRIOBP H-InvDB: TRIOBP

    (According to HUGE)
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    HUGE: KIAA1662

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIOBP Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TRIOBP gene:
    Search GeneIP for patents involving TRIOBP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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