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Aliases for TRIO Gene

Aliases for TRIO Gene

  • Trio Rho Guanine Nucleotide Exchange Factor 2 3
  • Triple Functional Domain (PTPRF Interacting) 2 3
  • PTPRF-Interacting Protein 3 4
  • EC 2.7.11.1 4 63
  • Triple Functional Domain Protein 3
  • ARHGEF23 3
  • Tgat 3

External Ids for TRIO Gene

Previous GeneCards Identifiers for TRIO Gene

  • GC05U990059
  • GC05P014425
  • GC05P014176
  • GC05P014196

Summaries for TRIO Gene

GeneCards Summary for TRIO Gene

TRIO (Trio Rho Guanine Nucleotide Exchange Factor) is a Protein Coding gene. Among its related pathways are Signaling by FGFR and Signaling by GPCR. GO annotations related to this gene include protein serine/threonine kinase activity and guanyl-nucleotide exchange factor activity. An important paralog of this gene is ARHGEF40.

UniProtKB/Swiss-Prot for TRIO Gene

  • Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth

Tocris Summary for TRIO Gene

Gene Wiki entry for TRIO Gene

No data available for Entrez Gene Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIO Gene

Genomics for TRIO Gene

Regulatory Elements for TRIO Gene

Genomic Location for TRIO Gene

Start:
14,143,702 bp from pter
End:
14,532,128 bp from pter
Size:
388,427 bases
Orientation:
Plus strand

Genomic View for TRIO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIO Gene

Proteins for TRIO Gene

  • Protein details for TRIO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75962-TRIO_HUMAN
    Recommended name:
    Triple functional domain protein
    Protein Accession:
    O75962
    Secondary Accessions:
    • D3DTD1
    • Q13458
    • Q59EQ7
    • Q6PJC9
    • Q6ZN05
    • Q8IWK8

    Protein attributes for TRIO Gene

    Size:
    3097 amino acids
    Molecular mass:
    346900 Da
    Quaternary structure:
    • Interacts to form a complex with leukocyte antigen related protein
    SequenceCaution:
    • Sequence=AAC34245.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC34245.1; Type=Frameshift; Positions=2301; Evidence={ECO:0000305}; Sequence=AAC43042.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIO Gene

    Alternative splice isoforms for TRIO Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIO Gene

Proteomics data for TRIO Gene at MOPED

Post-translational modifications for TRIO Gene

Other Protein References for TRIO Gene

Domains for TRIO Gene

Gene Families for TRIO Gene

HGNC:
  • ARHGEF :Rho guanine nucleotide exchange factors
  • ISET :Immunoglobulin superfamily / I-set domain containing
IUPHAR :

Suggested Antigen Peptide Sequences for TRIO Gene

Graphical View of Domain Structure for InterPro Entry

O75962

UniProtKB/Swiss-Prot:

TRIO_HUMAN :
  • O75962
Domain:
  • The N-terminal DBL/GEF domain specifically catalyzes nucleotide exchange for RAC1, leading to the activation of Jun kinase and the production of membrane ruffles. The second DBL/GEF domain is an exchange factor for rhoa and induces the formation of stress fibers
  • Contains 1 CRAL-TRIO domain.
  • Contains 2 DH (DBL-homology) domains.
  • Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
  • Contains 2 PH domains.
  • Contains 1 protein kinase domain.
  • Contains 2 SH3 domains.
Family:
  • Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.
Similarity:
  • Contains 4 spectrin repeats.
genes like me logo Genes that share domains with TRIO: view

Function for TRIO Gene

Molecular function for TRIO Gene

GENATLAS Biochemistry: trio phosphoprotein,with three enzymze domains,binding the LAR transmembrane tyrosine phosphatase (PTPRF),likely involved in active cell migration
UniProtKB/Swiss-Prot CatalyticActivity: ATP + a protein = ADP + a phosphoprotein
UniProtKB/Swiss-Prot Function: Promotes the exchange of GDP by GTP. Together with leukocyte antigen-related (LAR) protein, it could play a role in coordinating cell-matrix and cytoskeletal rearrangements necessary for cell migration and cell growth

Enzyme Numbers (IUBMB) for TRIO Gene

Gene Ontology (GO) - Molecular Function for TRIO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004672 protein kinase activity --
GO:0004674 protein serine/threonine kinase activity IEA --
GO:0004713 protein tyrosine kinase activity --
GO:0005085 guanyl-nucleotide exchange factor activity TAS 8643598
GO:0005089 Rho guanyl-nucleotide exchange factor activity IEA --
genes like me logo Genes that share ontologies with TRIO: view
genes like me logo Genes that share phenotypes with TRIO: view

Animal Models for TRIO Gene

MGI Knock Outs for TRIO:

No data available for Transcription Factor Targeting and HOMER Transcription for TRIO Gene

Localization for TRIO Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIO Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIO Gene COMPARTMENTS Subcellular localization image for TRIO gene
Compartment Confidence
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for TRIO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0016020 membrane --
genes like me logo Genes that share ontologies with TRIO: view

Pathways for TRIO Gene

genes like me logo Genes that share pathways with TRIO: view

Gene Ontology (GO) - Biological Process for TRIO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein phosphorylation IEA --
GO:0007185 transmembrane receptor protein tyrosine phosphatase signaling pathway TAS 8643598
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0007411 axon guidance TAS --
GO:0009103 lipopolysaccharide biosynthetic process --
genes like me logo Genes that share ontologies with TRIO: view

Compounds for TRIO Gene

(5) Tocris Compounds for TRIO Gene

Compound Action Cas Number
8-CPT-2Me-cAMP, sodium salt Selective Epac activator [634207-53-7]
8-pCPT-2-O-Me-cAMP-AM Selective Epac activator; cell-permeable analog of 8CPT-2Me-cAMP (Cat. No. 1645) [1152197-23-3]
Dynasore Non-competitive dynamin inhibitor [304448-55-3]
ML 141 Selective inhibitor of Cdc42 Rho family GTPase [71203-35-5]
Salirasib Ras inhibitor; also induces autophagy [162520-00-5]

(1) HMDB Compounds for TRIO Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1

(2) Novoseek inferred chemical compound relationships for TRIO Gene

Compound -log(P) Hits PubMed IDs
gdp 67.9 2
gtp 60.8 2
genes like me logo Genes that share compounds with TRIO: view

Transcripts for TRIO Gene

Unigene Clusters for TRIO Gene

Trio Rho guanine nucleotide exchange factor:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIO Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^ 23 ^
SP1: - -
SP2: - -
SP3:
SP4: -
SP5:
SP6:
SP7: -
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 24 ^ 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b · 36c ^ 37 ^ 38a · 38b ^ 39a · 39b · 39c ^ 40a · 40b ^ 41 ^ 42 ^
SP1: - - - -
SP2: - - - -
SP3: - - - -
SP4: - -
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13: -
SP14:
SP15:
SP16:
SP17:

ExUns: 43 ^ 44 ^ 45a · 45b ^ 46 ^ 47 ^ 48a · 48b ^ 49a · 49b ^ 50 ^ 51a · 51b ^ 52a · 52b · 52c · 52d ^ 53a · 53b ^ 54a · 54b ^ 55 ^ 56a · 56b ^ 57a · 57b ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3: - -
SP4:
SP5: - - -
SP6:
SP7:
SP8:
SP9: -
SP10: - - -
SP11:
SP12: -
SP13:
SP14:
SP15:
SP16:
SP17:

ExUns: 58 ^ 59a · 59b ^ 60 ^ 61a · 61b ·
SP1: -
SP2: -
SP3:
SP4:
SP5: -
SP6:
SP7:
SP8:
SP9: - -
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for TRIO Gene

GeneLoc Exon Structure for
TRIO
ECgene alternative splicing isoforms for
TRIO

Expression for TRIO Gene

mRNA expression in normal human tissues for TRIO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIO Gene

SOURCE GeneReport for Unigene cluster for TRIO Gene Hs.130031

mRNA Expression by UniProt/SwissProt for TRIO Gene

O75962-TRIO_HUMAN
Tissue specificity: Highly expressed in heart, skeletal muscle, brain, pancreas, placenta, liver, kidney and lung
genes like me logo Genes that share expressions with TRIO: view

No data available for mRNA differential expression in normal tissues for TRIO Gene

Orthologs for TRIO Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIO 35
  • 99.11 (n)
  • 99.13 (a)
TRIO 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIO 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIO 35
  • 90.95 (n)
  • 96.51 (a)
TRIO 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trio 35
  • 89.06 (n)
  • 96.5 (a)
Trio 16
Trio 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIO 36
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIO 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trio 35
  • 89.34 (n)
  • 96.3 (a)
chicken
(Gallus gallus)
Aves TRIO 35
  • 83.2 (n)
  • 95.01 (a)
TRIO 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 93 (a)
OneToMany
-- 36
  • 92 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia Xl.23955 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.3582 35
trio 35
  • 78 (n)
  • 90.05 (a)
zebrafish
(Danio rerio)
Actinopterygii trioa 35
  • 75.8 (n)
  • 84.03 (a)
trioa 36
  • 81 (a)
OneToMany
triob 36
  • 79 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006107 35
  • 55.82 (n)
  • 48.54 (a)
fruit fly
(Drosophila melanogaster)
Insecta trio 35
  • 53.49 (n)
  • 47.12 (a)
trio 36
  • 44 (a)
OneToMany
trio 37
  • 43 (a)
worm
(Caenorhabditis elegans)
Secernentea unc-73 35
  • 44.4 (n)
  • 32.06 (a)
unc-73 37
  • 27 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.3253 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 29 (a)
OneToMany
Species with no ortholog for TRIO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIO Gene

ENSEMBL:
Gene Tree for TRIO (if available)
TreeFam:
Gene Tree for TRIO (if available)

Paralogs for TRIO Gene

genes like me logo Genes that share paralogs with TRIO: view

Variants for TRIO Gene

Sequence variations from dbSNP and Humsavar for TRIO Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs12181 -- 14,498,585(+) ACGTG(C/T)ATCGC reference, synonymous-codon, nc-transcript-variant
rs15277 -- 14,482,326(-) TTTAA(A/G)TGTCT intron-variant
rs26057 -- 14,203,901(+) TTGTT(A/G)ATTGT intron-variant
rs26058 -- 14,192,842(+) TGTCT(A/G)TTAAT intron-variant
rs26059 -- 14,187,660(-) AAAAT(G/T)CACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIO Gene

Variant ID Type Subtype PubMed ID
nsv516415 CNV Gain+Loss 19592680
esv2752061 CNV Gain 17911159
nsv511275 CNV Gain 21212237
nsv823008 CNV Gain 20364138
esv24520 CNV Loss 19812545
nsv830209 CNV Gain 17160897
esv2729808 CNV Deletion 23290073
esv2410391 CNV Deletion 18987734
nsv4724 CNV Loss 18451855
esv2672857 CNV Deletion 23128226
nsv830210 CNV Gain 17160897
esv2729809 CNV Deletion 23290073
esv2729810 CNV Deletion 23290073
esv2138858 CNV Deletion 18987734
esv2421652 CNV Deletion 20811451
nsv442938 CNV CNV 18776908
esv1007471 CNV Insertion 20482838
esv2729811 CNV Deletion 23290073
esv2729812 CNV Deletion 23290073
esv2676264 CNV Deletion 23128226
nsv823010 CNV Loss 20364138
esv2729813 CNV Deletion 23290073
esv2537252 CNV Deletion 19546169
esv26100 CNV Loss 19812545
esv2658101 CNV Deletion 23128226
nsv4725 CNV Loss 18451855
nsv830211 CNV Loss 17160897
nsv823011 CNV Gain 20364138

Relevant External Links for TRIO Gene

HapMap Linkage Disequilibrium report
TRIO
Human Gene Mutation Database (HGMD)
TRIO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIO Gene

Disorders for TRIO Gene

Relevant External Links for TRIO

Genetic Association Database (GAD)
TRIO
Human Genome Epidemiology (HuGE) Navigator
TRIO
genes like me logo Genes that share disorders with TRIO: view

No data available for UniProtKB/Swiss-Prot for TRIO Gene

Publications for TRIO Gene

  1. NMR structure and mutagenesis of the N-terminal Dbl homology domain of the nucleotide exchange factor Trio. (PMID: 9790533) Liu X. … Fesik S.W. (Cell 1998) 3 4 23
  2. The multidomain protein Trio binds the LAR transmembrane tyrosine phosphatase, contains a protein kinase domain, and has separate rac- specific and rho-specific guanine nucleotide exchange factor domains. (PMID: 8643598) Debant A. … Streuli M. (Proc. Natl. Acad. Sci. U.S.A. 1996) 2 3 4
  3. Trio amino-terminal guanine nucleotide exchange factor domain expression promotes actin cytoskeleton reorganization, cell migration and anchorage-independent cell growth. (PMID: 10341202) Seipel K. … Streuli M. (J. Cell Sci. 1999) 3 4
  4. The guanine nucleotide exchange factors trio, Ect2, and Vav3 mediate the invasive behavior of glioblastoma. (PMID: 19008376) Salhia B. … Rutka J.T. (Am. J. Pathol. 2008) 3 23
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TRIO Gene

Sources for TRIO Gene

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