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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIML2 Gene

protein-coding   GIFtS: 44
GCID: GC04M189012

tripartite motif family-like 2
  Search for TRIML2
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIML2    

Aliases
for TRIML2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Family-Like 21 2     FLJ258011
SPRYD61 2 3     Probable E3 Ubiquitin-Protein Ligase TRIML22
Tripartite Motif Family-Like Protein 22 3     SPRY Domain Containing 62
SPRY Domain-Containing Protein 62 3     EC 6.3.2.-3

External Ids:    HGNC: 263781   Entrez Gene: 2058602   Ensembl: ENSG000001790467   UniProtKB: Q8N7C33   

Export aliases for TRIML2 gene to outside databases

Previous GC identifers: GC04M189250 GC04M184748


Summaries
for TRIML2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TRIML2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.1  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIML2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Evi-1   PPAR-alpha   Nkx3-1 v2   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIML2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIML2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

TRIML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIML2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M189012:  view genomic region     (about GC identifiers)

Start:
 189,012,427 bp from pter      End:
 189,030,757 bp from pter
Size:
 18,331 bases      Orientation:
 minus strand

Proteins
for TRIML2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase TRIML2  
Size: 387 amino acids; 43983 Da

Explore the universe of human proteins at neXtProt for TRIML2: NX_Q8N7C3

TRIML2 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_775824.1  
ENSEMBL proteins: 
 ENSP00000422581   ENSP00000317498   ENSP00000421575   ENSP00000426074   ENSP00000441236  

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Uscn Proteins for TRIML2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----


TRIML2 for ontologies           About GeneDecksing



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Protein Domains /
Families
for TRIML2 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
TRIML2 for domains           About GeneDecksing

5 InterPro domains/families:
 IPR006574 PRY
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR003879 Butyrophylin
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q8N7C3

ProtoNet protein and cluster: Q8N7C3

1 Blocks protein family: IPB003879 Butyrophylin C-terminal DUF signature

UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3
Similarity: Contains 1 B30.2/SPRY domain


Function
for TRIML2 gene

(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section
Enzyme Number (IUBMB): EC 6.3.2.-1

miRNA
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In Situ Assay
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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008270zinc ion binding ----
GO:0016874ligase activity IEA--


TRIML2 for ontologies           About GeneDecksing



Pathways & Interactions
for TRIML2 gene

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3
Pathway: Protein modification; protein ubiquitination

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIML2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TRIML2 (Q8N7C33 ENSP000003174984) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0032526response to retinoic acid IEA--
GO:0042221response to chemical stimulus ----


TRIML2 for ontologies           About GeneDecksing



Drugs & Compounds
for TRIML2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TRIML2
Search CenterWatch for drugs/clinical trials and news about TRIML2 / TRIMM 

Transcripts
for TRIML2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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About This Section
REFSEQ mRNAs for TRIML2 gene: 
NM_173553.1  

Unigene Cluster for TRIML2:

Tripartite motif family-like 2
Hs.276429  [show with all ESTs]
Unigene Representative Sequence: BC143709
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000512729(uc003izk.1 uc003izl.2 uc011cle.1) ENST00000326754
ENST00000503475 ENST00000503141(uc003izj.1) ENST00000511771 ENST00000502707
ENST00000394461 ENST00000536972(uc011clf.1)

miRNA
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Inhib. RNA
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Clone
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Additional cDNA sequence: 

AK098667.1 AK300428.1 AY435043.1 AY435044.1 BC111959.1 BC111961.1 BC143709.1 

1 DOTS entry:

DT.40274006 

9 AceView cDNA sequences:

BM423837 AY435044 AY435043 NM_173553 AK098667 AI192180 BX390776 AA729485 
CD247097 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TRIML2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:                                          
SP2:                                          
SP3:                                -         


ECgene alternative splicing isoforms for TRIML2

Expression
for TRIML2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIML2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCCTTCTTG

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)
About this image

TRIML2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
Stem Cell Differentiation: 4 LifeMap Cells 
NameCategory
PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
PureStem™ progenitor T42 (Embryonic Progenitor Cell)
PureStem™ progenitor W8 (Embryonic Progenitor Cell)
PureStem™ progenitor Z1 (Embryonic Progenitor Cell)
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See TRIML2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIML2

SOURCE GeneReport for Unigene cluster: Hs.276429
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In Situ
Assay Products: 
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Orthologs
for TRIML2 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
This gene was present in the common ancestor of chordates.

Orthologs for TRIML2 gene from 1/8 species (see all 8)    About this table
Organism Taxonomic
classification		 Gene Description Human
Similarity		 Orthology
Type		 Details
zebrafish
(Danio rerio)		 Actinopterygii trim476
 tripartite motif containing 47
 14(a)
 possible ortholog
 10(26752552-26762609)


ENSEMBL Gene Tree for TRIML2 (if available)
TreeFam Gene Tree for TRIML2 (if available) 

Paralogs
for TRIML2 gene

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRIML2 gene
RFPL12  MEFV2  RFPL4AL12  RFPL4A2  RFPL32  RFPL22  RFPL4B2  
5 SIMAP similar genes for TRIML2 using alignment to 3 protein entries:     TRIMM_HUMAN (see all proteins):
FLJ25801    TRIML1    TRIM27    MEFV    TRIM58

TRIML2 for paralogs           About GeneDecksing



Genomic Variants
for TRIML2 gene

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TRIML2
     6 CNVs: 8468 51353 32679 51354 7437 34439
SABiosciences Cancer Mutation PCR Assays
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Disorders / Diseases
for TRIML2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
   --

Publications
for TRIML2 gene

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRIML2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIML2)		    Utopia: connect your pdf to the dynamic
world of online information

  1. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

External Searches for TRIML2 gene

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  
  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

Genome Databases showing TRIML2 gene

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 205860 HGNC: 26378 AceView: FLJ25801 Ensembl:ENSG00000179046 euGenes: HUgn205860
ECgene: TRIML2 H-InvDB: TRIML2

Other Databases showing TRIML2 gene

(According to HUGE)
About This Section
   --

Specialized Databases showing TRIML2 gene

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRIML2 Pharmacogenomics, SNPs, Pathways

Intellectual Property
for TRIML2 gene

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRIML2 gene:
Search GeneIP for patents involving TRIML2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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About This Section

 
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