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Aliases for TRIML2 Gene

Aliases for TRIML2 Gene

  • Tripartite Motif Family-Like 2 2 3
  • Tripartite Motif Family-Like Protein 2 3 4
  • SPRY Domain-Containing Protein 6 3 4
  • SPRYD6 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIML2 3
  • SPRY Domain Containing 6 2
  • EC 6.3.2.- 4

External Ids for TRIML2 Gene

Previous GeneCards Identifiers for TRIML2 Gene

  • GC04M189250
  • GC04M189012
  • GC04M184748

Summaries for TRIML2 Gene

Entrez Gene Summary for TRIML2 Gene

  • This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for TRIML2 Gene

TRIML2 (Tripartite Motif Family-Like 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is RFPL4A.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIML2 Gene

Genomics for TRIML2 Gene

Regulatory Elements for TRIML2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIML2 Gene

Start:
188,091,273 bp from pter
End:
188,109,603 bp from pter
Size:
18,331 bases
Orientation:
Minus strand

Genomic View for TRIML2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIML2 Gene

Proteins for TRIML2 Gene

  • Protein details for TRIML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C3-TRIMM_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML2
    Protein Accession:
    Q8N7C3
    Secondary Accessions:
    • B7Z6J6

    Protein attributes for TRIML2 Gene

    Size:
    387 amino acids
    Molecular mass:
    43983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIML2 Gene

Proteomics data for TRIML2 Gene at MOPED

Post-translational modifications for TRIML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIML2 Gene

No data available for DME Specific Peptides for TRIML2 Gene

Domains for TRIML2 Gene

Protein Domains for TRIML2 Gene

Suggested Antigen Peptide Sequences for TRIML2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7C3

UniProtKB/Swiss-Prot:

TRIMM_HUMAN :
  • Q8N7C3
Domain:
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with TRIML2: view

No data available for Gene Families for TRIML2 Gene

Function for TRIML2 Gene

Enzyme Numbers (IUBMB) for TRIML2 Gene

Gene Ontology (GO) - Molecular Function for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIML2: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIML2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIML2 Gene

Localization for TRIML2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIML2 Gene COMPARTMENTS Subcellular localization image for TRIML2 gene
Compartment Confidence
cytosol 2
nucleus 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIML2 Gene

Pathways for TRIML2 Gene

SuperPathways for TRIML2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N7C3-TRIMM_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010033 response to organic substance --
GO:0016567 protein ubiquitination IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with TRIML2: view

No data available for Pathways by source for TRIML2 Gene

Transcripts for TRIML2 Gene

mRNA/cDNA for TRIML2 Gene

Unigene Clusters for TRIML2 Gene

Tripartite motif family-like 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIML2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TRIML2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: -

Relevant External Links for TRIML2 Gene

GeneLoc Exon Structure for
TRIML2
ECgene alternative splicing isoforms for
TRIML2

Expression for TRIML2 Gene

mRNA expression in normal human tissues for TRIML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIML2 Gene

This gene is overexpressed in Testis (26.7), Brain - Nucleus accumbens (basal ganglia) (4.3), and Brain - Putamen (basal ganglia) (4.3).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIML2 Gene

SOURCE GeneReport for Unigene cluster for TRIML2 Gene Hs.276429

genes like me logo Genes that share expressions with TRIML2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRIML2 Gene

Orthologs for TRIML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIML2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIML2 35
  • 98.7 (n)
  • 98.45 (a)
TRIML2 36
  • 92 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIML2 35
  • 75.61 (n)
  • 62.89 (a)
TRIML2 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
TRIML2 35
  • 74.87 (n)
  • 62.44 (a)
mouse
(Mus musculus)
Mammalia Triml2 35
  • 72.42 (n)
  • 60.27 (a)
Triml2 16
Triml2 36
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Triml2 35
  • 71.24 (n)
  • 57.8 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for TRIML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIML2 Gene

ENSEMBL:
Gene Tree for TRIML2 (if available)
TreeFam:
Gene Tree for TRIML2 (if available)

Paralogs for TRIML2 Gene

Paralogs for TRIML2 Gene

Selected SIMAP similar genes for TRIML2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIML2: view

Variants for TRIML2 Gene

Sequence variations from dbSNP and Humsavar for TRIML2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs902909 -- 188,100,311(-) TAACA(A/G)TGACC intron-variant
rs902910 -- 188,099,194(-) AGTAA(C/T)GAAGA intron-variant
rs2101668 -- 188,093,346(+) GGAGA(C/T)TGGCA intron-variant
rs2172342 -- 188,109,480(+) AGTAT(G/T)TTTCC upstream-variant-2KB
rs2172343 -- 188,109,481(+) GTATT(A/T)TTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIML2 Gene

Variant ID Type Subtype PubMed ID
dgv5855n71 CNV Gain 21882294
nsv523635 CNV Gain 19592680
esv32613 CNV Gain 17666407
esv2752041 CNV Gain 17911159
nsv880579 CNV Gain 21882294
nsv880478 CNV Loss 21882294
nsv880937 CNV Loss 21882294
nsv10629 CNV Loss 18304495
nsv461870 CNV Gain 19166990
nsv470098 CNV Gain 18288195
nsv880982 CNV Gain 21882294
nsv461871 CNV Gain 19166990
nsv881101 CNV Gain 21882294
dgv332n21 CNV Loss 19592680
nsv880458 CNV Gain 21882294
nsv830173 CNV Gain 17160897
nsv519300 CNV Gain+Loss 19592680
nsv880723 CNV Gain 21882294
esv2673712 CNV Deletion 23128226

Relevant External Links for TRIML2 Gene

HapMap Linkage Disequilibrium report
TRIML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIML2 Gene

Disorders for TRIML2 Gene

No disorders were found for TRIML2 Gene.

No data available for UniProtKB/Swiss-Prot for TRIML2 Gene

Publications for TRIML2 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  2. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PMID: 19394292) Ouyang J. … Gill G. (Mol. Cell 2009) 3
  3. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. (PMID: 25256710) Kung C.P. … Murphy M.E. (Mol. Cancer Res. 2015) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TRIML2 Gene

Sources for TRIML2 Gene

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