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Aliases for TRIML2 Gene

Aliases for TRIML2 Gene

  • Tripartite Motif Family Like 2 2 3 5
  • Tripartite Motif Family-Like Protein 2 3 4
  • SPRY Domain-Containing Protein 6 3 4
  • SPRYD6 3 4
  • Tripartite Motif Family-Like 2 3
  • SPRY Domain Containing 6 2
  • EC 6.3.2.- 4

External Ids for TRIML2 Gene

Previous GeneCards Identifiers for TRIML2 Gene

  • GC04M189250
  • GC04M189012
  • GC04M184748

Summaries for TRIML2 Gene

Entrez Gene Summary for TRIML2 Gene

  • This gene encodes a member of the tri-partite motif (TRIM) family of proteins. This protein may be regulated by the tumor suppressor p53 and may regulate p53 through the enhancement of p53 SUMOylation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]

GeneCards Summary for TRIML2 Gene

TRIML2 (Tripartite Motif Family Like 2) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM64C.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIML2 Gene

Genomics for TRIML2 Gene

Regulatory Elements for TRIML2 Gene

Promoters for TRIML2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIML2 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIML2 Gene

Chromosome:
4
Start:
188,091,255 bp from pter
End:
188,109,603 bp from pter
Size:
18,349 bases
Orientation:
Minus strand

Genomic View for TRIML2 Gene

Genes around TRIML2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIML2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIML2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIML2 Gene

Proteins for TRIML2 Gene

  • Protein details for TRIML2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N7C3-TRIMM_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML2
    Protein Accession:
    Q8N7C3
    Secondary Accessions:
    • B7Z6J6

    Protein attributes for TRIML2 Gene

    Size:
    387 amino acids
    Molecular mass:
    43983 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIML2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIML2 Gene

Proteomics data for TRIML2 Gene at MOPED

Post-translational modifications for TRIML2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIML2 Gene

No data available for DME Specific Peptides for TRIML2 Gene

Domains & Families for TRIML2 Gene

Protein Domains for TRIML2 Gene

Suggested Antigen Peptide Sequences for TRIML2 Gene

Graphical View of Domain Structure for InterPro Entry

Q8N7C3

UniProtKB/Swiss-Prot:

TRIMM_HUMAN :
  • Contains 1 B30.2/SPRY domain.
Domain:
  • Contains 1 B30.2/SPRY domain.
genes like me logo Genes that share domains with TRIML2: view

No data available for Gene Families for TRIML2 Gene

Function for TRIML2 Gene

Enzyme Numbers (IUBMB) for TRIML2 Gene

Gene Ontology (GO) - Molecular Function for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIML2: view
genes like me logo Genes that share phenotypes with TRIML2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIML2 Gene

Localization for TRIML2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIML2 Gene COMPARTMENTS Subcellular localization image for TRIML2 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 2
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIML2 Gene

Pathways & Interactions for TRIML2 Gene

SuperPathways for TRIML2 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N7C3-TRIMM_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIML2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0032526 response to retinoic acid IEA --
genes like me logo Genes that share ontologies with TRIML2: view

No data available for Pathways by source and SIGNOR curated interactions for TRIML2 Gene

Drugs & Compounds for TRIML2 Gene

No Compound Related Data Available

Transcripts for TRIML2 Gene

mRNA/cDNA for TRIML2 Gene

Unigene Clusters for TRIML2 Gene

Tripartite motif family-like 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIML2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2:
SP3: -

Relevant External Links for TRIML2 Gene

GeneLoc Exon Structure for
TRIML2
ECgene alternative splicing isoforms for
TRIML2

Expression for TRIML2 Gene

mRNA expression in normal human tissues for TRIML2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIML2 Gene

This gene is overexpressed in Testis (x26.7), Brain - Nucleus accumbens (basal ganglia) (x4.3), and Brain - Putamen (basal ganglia) (x4.3).

Protein differential expression in normal tissues from HIPED for TRIML2 Gene

This gene is overexpressed in Heart (35.2) and Platelet (33.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIML2 Gene



SOURCE GeneReport for Unigene cluster for TRIML2 Gene Hs.276429

genes like me logo Genes that share expression patterns with TRIML2: view

Protein tissue co-expression partners for TRIML2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRIML2 Gene

Orthologs for TRIML2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIML2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIML2 35
  • 75.61 (n)
  • 62.89 (a)
TRIML2 36
  • 54 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIML2 35
  • 74.87 (n)
  • 62.44 (a)
-- 36
  • 48 (a)
OneToMany
-- 36
  • 54 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Triml2 35
  • 72.42 (n)
  • 60.27 (a)
Triml2 16
Triml2 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIML2 35
  • 98.7 (n)
  • 98.45 (a)
TRIML2 36
  • 92 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Triml2 35
  • 71.24 (n)
  • 57.8 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 35 (a)
OneToMany
-- 36
  • 39 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 29 (a)
OneToMany
-- 36
  • 31 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for TRIML2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIML2 Gene

ENSEMBL:
Gene Tree for TRIML2 (if available)
TreeFam:
Gene Tree for TRIML2 (if available)

Paralogs for TRIML2 Gene

(5) SIMAP similar genes for TRIML2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIML2: view

Variants for TRIML2 Gene

Sequence variations from dbSNP and Humsavar for TRIML2 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs902909 -- 188,100,311(-) TAACA(A/G)TGACC intron-variant
rs902910 -- 188,099,194(-) AGTAA(C/G/T)GAAGA intron-variant
rs2101668 -- 188,093,346(+) GGAGA(C/T)TGGCA intron-variant
rs2172342 -- 188,109,480(+) AGTAT(G/T)TTTCC utr-variant-5-prime
rs2172343 -- 188,109,481(+) GTATT(A/T)TTCCC utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIML2 Gene

Variant ID Type Subtype PubMed ID
dgv5855n71 CNV Gain 21882294
nsv523635 CNV Gain 19592680
esv32613 CNV Gain 17666407
esv2752041 CNV Gain 17911159
nsv880579 CNV Gain 21882294
nsv880478 CNV Loss 21882294
nsv880937 CNV Loss 21882294
nsv10629 CNV Loss 18304495
nsv461870 CNV Gain 19166990
nsv470098 CNV Gain 18288195
nsv880982 CNV Gain 21882294
nsv461871 CNV Gain 19166990
nsv881101 CNV Gain 21882294
dgv332n21 CNV Loss 19592680
nsv880458 CNV Gain 21882294
nsv830173 CNV Gain 17160897
nsv519300 CNV Gain+Loss 19592680
nsv880723 CNV Gain 21882294
esv2673712 CNV Deletion 23128226

Variation tolerance for TRIML2 Gene

Residual Variation Intolerance Score: 91.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.79; 47.36% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIML2 Gene

HapMap Linkage Disequilibrium report
TRIML2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIML2 Gene

Disorders for TRIML2 Gene

Relevant External Links for TRIML2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIML2

No disorders were found for TRIML2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIML2 Gene

Publications for TRIML2 Gene

  1. Identification of TRIML2, a novel p53 target, that enhances p53 SUMOylation and regulates the transactivation of proapoptotic genes. (PMID: 25256710) Kung C.P. … Murphy M.E. (Mol. Cancer Res. 2015) 3 67
  2. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PMID: 19394292) Ouyang J. … Gill G. (Mol. Cell 2009) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRIML2 Gene

Sources for TRIML2 Gene

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