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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIML2 Gene

protein-coding   GIFtS: 44
GCID: GC04M189012

Tripartite Motif Family-Like 2

  Search for TRIML2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Family-Like 21 2     SPRY Domain-Containing Protein 62 3
SPRY Domain Containing 61 2     Probable E3 Ubiquitin-Protein Ligase TRIML22
Tripartite Motif Family-Like Protein 22 3     EC 6.3.2.-3
SPRYD62 3     

External Ids:    HGNC: 263781   Entrez Gene: 2058602   Ensembl: ENSG000001790467   UniProtKB: Q8N7C33   

Export aliases for TRIML2 gene to outside databases

Previous GC identifers: GC04M189250 GC04M184748


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIML2 Gene: 
TRIML2 (tripartite motif family-like 2) is a protein-coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM43.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIML2 gene promoter:
         Nkx3-1   Nkx3-1 v4   Nkx3-1 v1   Evi-1   PPAR-alpha   Nkx3-1 v2   PPAR-gamma1   Nkx3-1 v3   PPAR-gamma2   Zic3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIML2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIML2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIML2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

TRIML2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIML2 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M189012:  view genomic region     (about GC identifiers)

Start:
189,012,427 bp from pter      End:
189,030,757 bp from pter
Size:
18,331 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase TRIML2  
Size: 387 amino acids; 43983 Da

Explore the universe of human proteins at neXtProt for TRIML2: NX_Q8N7C3

Explore proteomics data for TRIML2 at MOPED 

TRIML2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TRIML2 Protein Expression

REFSEQ proteins: NP_775824.1  
ENSEMBL proteins: 
 ENSP00000422581   ENSP00000317498   ENSP00000421575   ENSP00000426074   ENSP00000441236  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----

TRIML2 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
5 InterPro protein domains:
 IPR006574 PRY
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR003879 Butyrophylin
 IPR008985 ConA-like_lec_gl_sf

Graphical View of Domain Structure for InterPro Entry Q8N7C3

ProtoNet protein and cluster: Q8N7C3

1 Blocks protein domain: IPB003879 Butyrophylin C-terminal DUF signature

UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3
Similarity: Contains 1 B30.2/SPRY domain


TRIML2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Enzyme Number (IUBMB): EC 6.3.2.-1

     Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding ----
GO:0016874ligase activity IEA--
     
TRIML2 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



UniProtKB/Swiss-Prot: TRIMM_HUMAN, Q8N7C3
Pathway: Protein modification; protein ubiquitination

Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIML2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for TRIML2 (Q8N7C33 ENSP000003174984) via UniProtKB, MINT, STRING, and/or I2D

InteractantInteraction Details
GeneCardExternal ID(s)
SUMO2P619563, ENSP000004059654I2D: score=1 STRING: ENSP00000405965
About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016567protein ubiquitination IEA--
GO:0032526response to retinoic acid IEA--
GO:0042221response to chemical stimulus ----

TRIML2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRIML2 (TRIMM)

Search CenterWatch for drugs/clinical trials and news about TRIML2 / TRIMM

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIML2 gene: 
NM_173553.1  

Unigene Cluster for TRIML2:

Tripartite motif family-like 2
Hs.276429  [show with all ESTs]
Unigene Representative Sequence: BC143709
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000512729(uc003izk.1 uc003izl.2 uc011cle.1) ENST00000326754
ENST00000503475 ENST00000503141(uc003izj.1) ENST00000511771 ENST00000502707
ENST00000394461 ENST00000536972(uc011clf.1)
miRNA
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Additional mRNA sequence: 

AK098667.1 AK300428.1 AY435043.1 AY435044.1 BC111959.1 BC111961.1 BC143709.1 

1 DOTS entry:

DT.40274006 

9 AceView cDNA sequences:

AY435044 BM423837 AY435043 NM_173553 AK098667 AA729485 BX390776 AI192180 
CD247097 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for TRIML2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:                                          
SP2:                                          
SP3:                                -         


ECgene alternative splicing isoforms for TRIML2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIML2 expression in normal human tissues (normalized intensities)      TRIML2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GTCCTTCTTG
TRIML2 Expression
About this image


TRIML2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/14 selected tissues (see all 14) fully expand
 
 Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 7 entries
         Line H9 (WA09)
         ESI-049   
 
 Endothelium (Cardiovascular System)    fully expand to see all 6 entries
         PureStem endothelial progenitor RP1-MV2-18
         Human Renal Glomerular Endothelial Cells (HRGEC)   
 
 Uncategorized (Uncategorized)    fully expand to see all 4 entries
         PureStem progenitor RP1-MV2-16
 
 Brain (Nervous System)    fully expand to see all 4 entries
         ganglion/cranial/facial VII   
 
 Dermis (Hematopoietic System)    fully expand to see all 2 entries
         Human Dermal Microvascular Endothelial Cells (HDMEC)   

See TRIML2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIML2

SOURCE GeneReport for Unigene cluster: Hs.276429
    SABiosciences Custom PCR Arrays for TRIML2
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In Situ
Assay Products:
 

 
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TRIML2 gene from 3/9 species (see all 9)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Triml21 , 5 tripartite motif family-like 21, 5 72.33(n)1
60.27(a)1
  8 (23.89 cM)5
6221171  NM_001160412.11  NP_001153884.11 
 431831225 
chicken
(Gallus gallus)
Aves ZNF7776
Uncharacterized protein
32(a)
possible ortholog
2(564030-564628)
zebrafish
(Danio rerio)
Actinopterygii btr306
bloodthirsty-related gene family, member 30
13(a)
possible ortholog
19(49825613-49832914)


ENSEMBL Gene Tree for TRIML2 (if available)
TreeFam Gene Tree for TRIML2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRIML2 gene
TRIM432  TRIML12  TRIM772  TRIM492  TRIM64B2  TRIM49B2  TRIM64C2  TRIM49C2  
TRIM512  TRIM482  TRIM49D12  
6 SIMAP similar genes for TRIML2 using alignment to 3 protein entries:     TRIMM_HUMAN (see all proteins):
FLJ25801    TRIML1    TRIM11    TRIM27    MEFV    TRIM58

TRIML2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/518 SNPs in TRIML2 are shown (see all 518)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs106078521,2
C--184754264(+) AAAAA-/AA/AAA
        
GATTT
1 -- int11NA 2
rs572837491,2
C--189011929(+) TGAGCT/CAAGAT 1 -- ds50012Minor allele frequency- C:0.44CSA EA 122
rs76984721,2
C,F,A--189011930(+) GAGCCA/GAGATC 1 -- ds50016Minor allele frequency- G:0.38NA WA CSA EA 248
rs1854235831,2
--189011997(+) AAAAGA/GAAAGA 1 -- ds50010--------
rs1894642591,2
--189012043(+) CTTATC/TCACAT 1 -- ds50010--------
rs1808397171,2
--189012046(+) ATCCAC/TATAAA 1 -- ds50010--------
rs1850458461,2
--189012138(+) GTTCCA/GCATGG 1 -- ds50010--------
rs1884819241,2
--189012245(+) GGACCC/TCAGAC 1 -- ds50010--------
rs1161085911,2
F--189012290(+) CATATG/CCATTT 1 -- ds50011Minor allele frequency- C:0.02WA 118
rs1491711021,2
C--189012435(+) GGAACA/GCTTTT 1 -- ut310--------

HapMap Linkage Disequilibrium report for TRIML2 (189012427 - 189030757 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/19 variations for TRIML2 (see all 19):    About this table     
Variant IDTypeSubtypePubMed ID
esv2673712CNV Deletion23128226
nsv880937CNV Loss21882294
dgv332n21CNV Loss19592680
nsv880478CNV Loss21882294
nsv10629CNV Loss18304495
nsv880458CNV Gain21882294
nsv461871CNV Gain19166990
nsv880982CNV Gain21882294
nsv461870CNV Gain19166990
esv2752041CNV Gain17911159

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRIML2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIML2)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Direct binding of CoREST1 to SUMO-2/3 contributes to gene-specific repression by the LSD1/CoREST1/HDAC complex. (PubMed id 19394292)1 Ouyang J....Gill G. (2009)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 205860 HGNC: 26378 AceView: FLJ25801 Ensembl:ENSG00000179046 euGenes: HUgn205860
ECgene: TRIML2 H-InvDB: TRIML2

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRIML2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRIML2 gene:
Search GeneIP for patents involving TRIML2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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