TRIML1 Gene
protein-coding GIFtS: 41
GCID: GC04P189060
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|
tripartite motif family-like 1
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Aliases
for TRIML1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Family-Like 11 2 | | FLJ361801 | | RNF2091 2 3 | | Probable E3 Ubiquitin-Protein Ligase TRIML12 | | Tripartite Motif Family-Like Protein 12 3 | | EC 6.3.2.-3 | | RING Finger Protein 2092 3 | | |
Export aliases for TRIML1 gene to outside databasesPrevious GC identifers: GC04P189298 GC04P184797 |
Summaries
for TRIML1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By similarity)
|
Genomic Views
for TRIML1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIML1 gene promoter:
SRF SRF (504 AA) C/EBPalpha GATA-1 AREB6 PPAR-alpha POU2F1 POU2F1a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIML1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIML1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q35.2 Ensembl cytogenetic band: 4q35.2 HGNC cytogenetic band: 4q35.2TRIML1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P189060: view genomic region
(about GC identifiers)
Start:
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189,060,573 bp from pter |
End:
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189,068,897 bp from pter |
Size:
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8,325 bases |
Orientation:
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plus strand |
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Proteins
for TRIML1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2 (See
protein sequence)Recommended Name: Probable E3 ubiquitin-protein ligase TRIML1 Size: 468 amino acids; 53002 Da
Subunit: Interacts with USP5 (By similarity)
Secondary accessions: Q96BE5Explore the universe of human proteins at neXtProt for TRIML1: NX_Q8N9V2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N9V2
TRIML1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_848651.2
ENSEMBL proteins: ENSP00000327738
Human Recombinant Protein Products:
TRIML1 Antibody Products:
Assay Products for TRIML1: |
Protein
Domains /
Families
for TRIML1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIML1 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q8N9V2ProtoNet protein and cluster: Q8N9V2 3 Blocks protein families: IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2Similarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIML1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By similarity)Enzyme Number (IUBMB): EC 6.3.2.-1
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIML1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIML1 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table
TRIML1 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TRIML1:
|
Pathways & Interactions
for TRIML1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIML1
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TRIML1 (ENSP000003277384) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0016567 | protein ubiquitination |
IEA | -- |
TRIML1 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIML1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIML1
Search CenterWatch for drugs/clinical trials and news about TRIML1 / TRIML
|
Transcripts
for TRIML1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIML1 gene: NM_178556.3 Unigene Cluster for TRIML1: Tripartite motif family-like 1 Hs.348618 [show with all ESTs]Unigene Representative Sequence: NM_1785563 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000332517(uc003izm.1) ENST00000507581(uc003izn.1) ENST00000512233
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIML1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIML1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIML1 (NM_178556) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIML1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIML1 |
Additional cDNA sequence: AK093499.1 BC015684.2 BC113860.1 BC114469.1 2 DOTS entries: DT.99927748 DT.40280832 8 AceView cDNA sequences: AK093499 BI090502 NM_178556 AX748169 BC015684 AI004453 BG479993 BI832301
GeneLoc Exon Structure
|
Expression
for TRIML1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIML1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TRIML1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIML1
SOURCE GeneReport for Unigene cluster: Hs.348618
SABiosciences Expression via Pathway-Focused PCR Array including TRIML1:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIML1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIML1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIML1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIML1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIML1 |
Orthologs
for TRIML1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIML1 gene from 1/8 species (see all 8) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
24(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIML1 (if available)
TreeFam Gene Tree for TRIML1 (if available) |
Paralogs
for TRIML1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIML1 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIM272 TRIM582 TRIM682
- TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/29 SIMAP similar genes for TRIML1 using alignment to 1 protein entry: TRIML_HUMAN(see all similar genes):TRIM21 TRIM11 TRIM39 TRIML2 TRIM64 TRIM43
TRIM43B TRIM49B TRIM58 TRIM64B TRIM68 TRIM49C
TRIM64C DKFZp781D1977 TRIM27 TRIM49 TRIM49D2P TRIM51
TRIML1 for paralogs About GeneDecksing
|
Genomic Variants
for TRIML1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TRIML1
6 CNVs: 36251 36250 51353 51354 7437 34439 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIML1 |
|
Disorders
/ Diseases
for TRIML1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TRIML1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIML1 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIML1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Characterization and potential function of a novel pre -implantation embryo-specific RING finger protein: TRIML1. (PubMed id 19156909)1 Tian L....Chen H. (2009)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
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External Searches for TRIML1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIML1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIML1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIML1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIML1 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIML1 gene:
Search GeneIP for patents involving TRIML1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIML1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TRIML1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIML1 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIML1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIML1 |
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