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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIML1 Gene

protein-coding   GIFtS: 43
GCID: GC04P189060

Tripartite Motif Family-Like 1

  Search for TRIML1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Family-Like 11 2
Tripartite Motif Family-Like Protein 12 3
RNF2092 3
RING Finger Protein 2092 3
Probable E3 Ubiquitin-Protein Ligase TRIML12
EC 6.3.2.-3

External Ids:    HGNC: 266981   Entrez Gene: 3399762   Ensembl: ENSG000001841087   UniProtKB: Q8N9V23   

Export aliases for TRIML1 gene to outside databases

Previous GC identifers: GC04P189298 GC04P184797


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIML1 Gene: 
TRIML1 (tripartite motif family-like 1) is a protein-coding gene. GO annotations related to this gene include zinc ion binding and ligase activity. An important paralog of this gene is TRIML2.

UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2
Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NC_018915.2  NT_016354.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIML1 gene promoter:
         SRF   SRF (504 AA)   C/EBPalpha   GATA-1   AREB6   PPAR-alpha   POU2F1   POU2F1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIML1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIML1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIML1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q35.2   Ensembl cytogenetic band:  4q35.2   HGNC cytogenetic band: 4q35.2

TRIML1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIML1 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P189060:  view genomic region     (about GC identifiers)

Start:
189,060,573 bp from pter      End:
189,068,897 bp from pter
Size:
8,325 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase TRIML1  
Size: 468 amino acids; 53002 Da
Subunit: Interacts with USP5 (By similarity)
Secondary accessions: Q96BE5

Explore the universe of human proteins at neXtProt for TRIML1: NX_Q8N9V2

Explore proteomics data for TRIML1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8N9V2

  • TRIML1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIML1 Protein Expression
    REFSEQ proteins: NP_848651.2  
    ENSEMBL proteins: 
     ENSP00000327738  

    Human Recombinant Protein Products for TRIML1: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RNF: RING-type (C3HC4) zinc fingers

    5/9 InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q8N9V2

    ProtoNet protein and cluster: Q8N9V2

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIML1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIML_HUMAN, Q8N9V2
    Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development (By
    similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0016874ligase activity IEA--
    GO:0046872metal ion binding ----
         
    TRIML1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIML1:
     Downregulation of NF-kappaB pa 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIML1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIML1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIML1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIML1 

    miRNA
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    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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                         Customized lentivirus expression plasmids for stable overexpression of TRIML1 

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIML1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRIML_HUMAN, Q8N9V2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIML1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TRIML1 (ENSP000003277384) via UniProtKB, MINT, STRING, and/or I2D

    InteractantInteraction Details
    GeneCardExternal ID(s)
    USP5ENSP000002292684STRING: ENSP00000229268
    MNAT1ENSP000002612454STRING: ENSP00000261245
    RBCK1ENSP000003486324STRING: ENSP00000348632
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016567protein ubiquitination IEA--

    TRIML1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIML1 (TRIML)

    Search CenterWatch for drugs/clinical trials and news about TRIML1 / TRIML

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIML1 gene: 
    NM_178556.3  

    Unigene Cluster for TRIML1:

    Tripartite motif family-like 1
    Hs.348618  [show with all ESTs]
    Unigene Representative Sequence: NM_178556
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000332517(uc003izm.1) ENST00000507581(uc003izn.1) ENST00000512233

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIML1
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TRIML1
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TRIML1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIML1
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIML1 (see all 7)
    OriGene ORF clones in mouse, rat for TRIML1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIML1 (NM_178556)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIML1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIML1
    Sirion Biotech Customized lentivirus for stable overexpression of TRIML1 
                         Customized lentivirus expression plasmids for stable overexpression of TRIML1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIML1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIML1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIML1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIML1

    Additional mRNA sequence: 

    AK093499.1 BC015684.2 BC113860.1 BC114469.1 

    2 DOTS entries:

    DT.99927748  DT.40280832 

    8 AceView cDNA sequences:

    NM_178556 BC015684 AX748169 AK093499 BI090502 AI004453 BG479993 BI832301 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIML1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRIML1 Expression
    About this image


    See TRIML1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIML1

    SOURCE GeneReport for Unigene cluster: Hs.348618
        SABiosciences Expression via Pathway-Focused PCR Array including TRIML1: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIML1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIML1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TRIML1 gene from 1/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Triml11 , 5 tripartite motif family-like 11, 5 80.17(n)1
    80.82(a)1
      8 (23.89 cM)5
    2444481  NM_177742.41  NP_808410.11 
     431298075 


    ENSEMBL Gene Tree for TRIML1 (if available)
    TreeFam Gene Tree for TRIML1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIML1 gene
    TRIML22  TRIM432  TRIM772  TRIM492  TRIM64B2  TRIM49B2  TRIM64C2  TRIM49C2  
    TRIM512  TRIM482  TRIM49D12  
    18/28 SIMAP similar genes for TRIML1 using alignment to 1 protein entry:     TRIML_HUMAN(see all similar genes):
    TRIM11    TRIM21    TRIM39    TRIML2    TRIM64    TRIM43
    TRIM43B    TRIM49B    TRIM58    TRIM64B    TRIM68    TRIM49C
    TRIM64C    DKFZp781D1977    TRIM27    TRIM49    TRIM51    TRIM6

    TRIML1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/441 SNPs in TRIML1 are shown (see all 441)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0359634
    A breast cancer sample4--see VAR_0359632 D H mis40--------
    rs709387011,2
    C--189058630(+) TTTTT-/TGAGAC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1391519731,2
    --189058662(+) GTTTCA/GCTTTT 1 -- us2k10--------
    rs1908531221,2
    --189058791(+) CATGCC/TCGGCT 1 -- us2k10--------
    rs1474514771,2
    C--189058926(+) GCACCC/TGGCCT 1 -- us2k10--------
    rs117236731,2
    C,F,H--189058938(+) ATTTTC/AATATT 1 -- us2k1 tfbs31Minor allele frequency- A:0.33NA 6
    rs361710231,2
    C,F--189058968(+) CACCAC/TGTTGG 1 -- us2k11Minor allele frequency- T:0.50NA 2
    rs1832156151,2
    --189059056(+) GCAACC/TGCGCC 1 -- us2k10--------
    rs74415861,2
    C,F,A,H--189059078(+) TTTTTT/CTTTTT 1 -- us2k1 trp317Minor allele frequency- C:0.19NS EA NA WA CSA 1985
    rs1492930901,2
    C--189059078(+) TTTTT-/CTTTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIML1 (189060573 - 189068897 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/20 variations for TRIML1 (see all 20):    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509029CNV Insertion20534489
    nsv4655CNV Insertion18451855
    nsv880937CNV Loss21882294
    dgv332n21CNV Loss19592680
    nsv880478CNV Loss21882294
    nsv10629CNV Loss18304495
    nsv4653CNV Loss18451855
    nsv880458CNV Gain21882294
    nsv880982CNV Gain21882294
    nsv461870CNV Gain19166990

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIML1
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIML1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIML1 for disorders           About MalaCards

    TRIML1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIML1

    Export disorders for TRIML1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIML1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRIML1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
    4. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    5. Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
    6. Characterization and potential function of a novel pre -implantation embryo-specific RING finger protein: TRIML1. (PubMed id 19156909)1 Tian L....Chen H. (2009)
    7. The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
    8. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 339976 HGNC: 26698 AceView: FLJ36180 Ensembl:ENSG00000184108 euGenes: HUgn339976
    ECgene: TRIML1 H-InvDB: TRIML1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIML1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIML1 gene:
    Search GeneIP for patents involving TRIML1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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