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Aliases for TRIML1 Gene

Aliases for TRIML1 Gene

  • Tripartite Motif Family Like 1 2 3 5
  • RING Finger Protein 209 3 4
  • RNF209 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIML1 3
  • Tripartite Motif Family-Like Protein 1 4
  • EC 6.3.2.- 4

External Ids for TRIML1 Gene

Previous GeneCards Identifiers for TRIML1 Gene

  • GC04P189298
  • GC04P189060
  • GC04P184797

Summaries for TRIML1 Gene

Entrez Gene Summary for TRIML1 Gene

  • The protein encoded by this gene is a tripartite motif family protein with similarities to E3 ubiquitin-protein ligases. While the function of the encoded protein has not been determined, the orthologous protein in mouse has been shown to bind ubiquitin-specific protease 5 and is involved in the blastocyst development stage. [provided by RefSeq, Sep 2016]

GeneCards Summary for TRIML1 Gene

TRIML1 (Tripartite Motif Family Like 1) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIML2.

UniProtKB/Swiss-Prot for TRIML1 Gene

  • Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIML1 Gene

Genomics for TRIML1 Gene

Regulatory Elements for TRIML1 Gene

Enhancers for TRIML1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F188460 0.3 FANTOM5 52 +322.1 322090 0.3 TRIML1 LOC105377609 PIR32272
GH04F188179 0.3 FANTOM5 31.2 +41.4 41426 0.4 NFYB TRIML1 ENSG00000247130 RNU6-173P LOC105377607 PIR43852
GH04F188180 1.2 FANTOM5 11.6 +42.4 42424 0.4 ENSG00000247130 TRIML1 RNU6-173P TRIML2 PIR43852 GC04P188236
GH04F188127 1.3 FANTOM5 Ensembl ENCODE 0.4 -10.4 -10375 1.6 GTF2F1 JUN BHLHE40 MAX USF2 EP300 JUND FOS TCF7L2 TRIM28 TRIML2 LOC105377606 RNU6-173P TRIML1
GH04F188121 1.1 ENCODE 0.3 -16.4 -16353 0.6 MAX POU5F1 TRIML2 RNU6-173P TRIML1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIML1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIML1 Gene

Chromosome:
4
Start:
188,138,189 bp from pter
End:
188,147,743 bp from pter
Size:
9,555 bases
Orientation:
Plus strand

Genomic View for TRIML1 Gene

Genes around TRIML1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIML1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIML1 Gene

Proteins for TRIML1 Gene

  • Protein details for TRIML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V2-TRIML_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML1
    Protein Accession:
    Q8N9V2
    Secondary Accessions:
    • Q96BE5

    Protein attributes for TRIML1 Gene

    Size:
    468 amino acids
    Molecular mass:
    53002 Da
    Quaternary structure:
    • Interacts with USP5.

neXtProt entry for TRIML1 Gene

Post-translational modifications for TRIML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIML1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIML1 Gene

Domains & Families for TRIML1 Gene

Gene Families for TRIML1 Gene

Suggested Antigen Peptide Sequences for TRIML1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N9V2

UniProtKB/Swiss-Prot:

TRIML_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 RING-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIML1: view

Function for TRIML1 Gene

Molecular function for TRIML1 Gene

UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

Enzyme Numbers (IUBMB) for TRIML1 Gene

Gene Ontology (GO) - Molecular Function for TRIML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIML1: view
genes like me logo Genes that share phenotypes with TRIML1: view

Animal Model Products

miRNA for TRIML1 Gene

miRTarBase miRNAs that target TRIML1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIML1 Gene

Localization for TRIML1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIML1 Gene COMPARTMENTS Subcellular localization image for TRIML1 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIML1 Gene

Pathways & Interactions for TRIML1 Gene

SuperPathways for TRIML1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N9V2-TRIML_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for TRIML1 Gene

Gene Ontology (GO) - Biological Process for TRIML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIML1: view

No data available for Pathways by source and SIGNOR curated interactions for TRIML1 Gene

Transcripts for TRIML1 Gene

mRNA/cDNA for TRIML1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIML1 Gene

Tripartite motif family-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIML1 Gene

No ASD Table

Relevant External Links for TRIML1 Gene

GeneLoc Exon Structure for
TRIML1
ECgene alternative splicing isoforms for
TRIML1

Expression for TRIML1 Gene

mRNA expression in normal human tissues for TRIML1 Gene

mRNA differential expression in normal tissues according to GTEx for TRIML1 Gene

This gene is overexpressed in Testis (x51.9).

Protein differential expression in normal tissues from HIPED for TRIML1 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIML1 Gene



Protein tissue co-expression partners for TRIML1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIML1 Gene:

TRIML1

SOURCE GeneReport for Unigene cluster for TRIML1 Gene:

Hs.348618
genes like me logo Genes that share expression patterns with TRIML1: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIML1 Gene

Orthologs for TRIML1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIML1 34 35
  • 99.15 (n)
dog
(Canis familiaris)
Mammalia TRIML1 34 35
  • 84.62 (n)
cow
(Bos Taurus)
Mammalia TRIML1 34 35
  • 84.12 (n)
mouse
(Mus musculus)
Mammalia Triml1 34 16 35
  • 80.17 (n)
rat
(Rattus norvegicus)
Mammalia Triml1 34
  • 80.1 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 44 (a)
OneToMany
-- 35
  • 42 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 40 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 39 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 38 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
-- 35
  • 36 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 35 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 34 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
-- 35
  • 30 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 43 (a)
OneToMany
-- 35
  • 43 (a)
OneToMany
-- 35
  • 41 (a)
OneToMany
-- 35
  • 37 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
Species where no ortholog for TRIML1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIML1 Gene

ENSEMBL:
Gene Tree for TRIML1 (if available)
TreeFam:
Gene Tree for TRIML1 (if available)

Paralogs for TRIML1 Gene

Variants for TRIML1 Gene

Sequence variations from dbSNP and Humsavar for TRIML1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
VAR_035963 A breast cancer sample
rs193920871 Uncertain significance 188,147,153(+) TTGAA(A/T)GGTCA nc-transcript-variant, reference, missense
rs10010192 -- 188,136,458(+) GGGTT(C/T)ACGCC upstream-variant-2KB
rs10019679 -- 188,145,248(+) gcctg(C/G)ccaac intron-variant
rs10026403 -- 188,148,345(+) aaaaa(C/T)tagct intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIML1 Gene

Variant ID Type Subtype PubMed ID
dgv332n21 CNV loss 19592680
dgv5496n100 CNV gain 25217958
dgv5499n100 CNV gain 25217958
dgv5501n100 CNV gain 25217958
dgv9439n54 CNV gain 21841781
dgv9440n54 CNV gain 21841781
dgv9441n54 CNV loss 21841781
dgv9442n54 CNV gain 21841781
esv2763831 CNV gain+loss 21179565
esv32613 CNV gain 17666407
esv3569882 CNV loss 25503493
nsv1017684 CNV loss 25217958
nsv1019623 CNV gain 25217958
nsv1022128 CNV loss 25217958
nsv1022361 CNV gain 25217958
nsv1022807 CNV gain 25217958
nsv1031097 CNV loss 25217958
nsv1031236 CNV gain 25217958
nsv1031595 CNV gain 25217958
nsv10629 CNV loss 18304495
nsv1067931 OTHER inversion 25765185
nsv1128122 CNV deletion 24896259
nsv461870 CNV gain 19166990
nsv4653 CNV deletion 18451855
nsv4655 CNV insertion 18451855
nsv470098 CNV gain 18288195
nsv509029 CNV insertion 20534489
nsv519300 CNV gain+loss 19592680
nsv523635 CNV gain 19592680
nsv596460 CNV loss 21841781
nsv830173 CNV gain 17160897

Variation tolerance for TRIML1 Gene

Residual Variation Intolerance Score: 48.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.38; 85.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIML1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIML1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIML1 Gene

Disorders for TRIML1 Gene

Relevant External Links for TRIML1

Genetic Association Database (GAD)
TRIML1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIML1

No disorders were found for TRIML1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIML1 Gene

Publications for TRIML1 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations. (PMID: 24528284) Ji Y. … Weinshilboum R.M. (Br J Clin Pharmacol 2014) 3 64
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3 64

Products for TRIML1 Gene

Sources for TRIML1 Gene

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