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Aliases for TRIML1 Gene

Aliases for TRIML1 Gene

  • Tripartite Motif Family-Like 1 2 3
  • Tripartite Motif Family-Like Protein 1 3 4
  • RING Finger Protein 209 3 4
  • RNF209 3 4
  • Probable E3 Ubiquitin-Protein Ligase TRIML1 3
  • EC 6.3.2.- 4

External Ids for TRIML1 Gene

Summaries for TRIML1 Gene

GeneCards Summary for TRIML1 Gene

TRIML1 (Tripartite Motif Family-Like 1) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIML1 Gene

  • Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIML1 Gene

Genomics for TRIML1 Gene

Genomic Location for TRIML1 Gene

Start:
188,137,209 bp from pter
End:
188,147,743 bp from pter
Size:
10,535 bases
Orientation:
Plus strand

Genomic View for TRIML1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIML1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIML1 Gene

Regulatory Elements for TRIML1 Gene

Proteins for TRIML1 Gene

  • Protein details for TRIML1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N9V2-TRIML_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIML1
    Protein Accession:
    Q8N9V2
    Secondary Accessions:
    • Q96BE5

    Protein attributes for TRIML1 Gene

    Size:
    468 amino acids
    Molecular mass:
    53002 Da
    Quaternary structure:
    • Interacts with USP5.

neXtProt entry for TRIML1 Gene

Proteomics data for TRIML1 Gene at MOPED

Post-translational modifications for TRIML1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIML1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIML1 Gene

Domains for TRIML1 Gene

Gene Families for TRIML1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

UniProtKB/Swiss-Prot:

TRIML_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q8N9V2
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q8N9V2
genes like me logo Genes that share domains with TRIML1: view

Function for TRIML1 Gene

Molecular function for TRIML1 Gene

UniProtKB/Swiss-Prot Function: Probable E3 ubiquitin-protein ligase which plays an important role in blastocyst development.

Enzyme Numbers (IUBMB) for TRIML1 Gene

Gene Ontology (GO) - Molecular Function for TRIML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIML1: view

Phenotypes for TRIML1 Gene

GenomeRNAi human phenotypes for TRIML1:
genes like me logo Genes that share phenotypes with TRIML1: view

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIML1 Gene

Localization for TRIML1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIML1 Gene COMPARTMENTS Subcellular localization image for TRIML1 gene
Compartment Confidence
nucleus 3
cytosol 2
cytoskeleton 1
golgi apparatus 1

No data available for Gene Ontology (GO) - Cellular Components for TRIML1 Gene

Pathways for TRIML1 Gene

SuperPathways for TRIML1 Gene

No Data Available

UniProtKB/Swiss-Prot Q8N9V2-TRIML_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIML1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIML1: view

No data available for Pathways by source for TRIML1 Gene

Transcripts for TRIML1 Gene

mRNA/cDNA for TRIML1 Gene

(3) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIML1 Gene

Tripartite motif family-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIML1 Gene

No ASD Table

Relevant External Links for TRIML1 Gene

GeneLoc Exon Structure for
TRIML1
ECgene alternative splicing isoforms for
TRIML1

Expression for TRIML1 Gene

mRNA expression in normal human tissues for TRIML1 Gene

mRNA differential expression in normal tissues according to GTEx for TRIML1 Gene

This gene is overexpressed in Testis (51.9).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIML1 Gene

SOURCE GeneReport for Unigene cluster for TRIML1 Gene Hs.348618

genes like me logo Genes that share expressions with TRIML1: view

Orthologs for TRIML1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIML1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIML1 36
  • 99.15 (n)
  • 98.5 (a)
TRIML1 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIML1 36
  • 84.12 (n)
  • 84.19 (a)
TRIML1 37
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIML1 36
  • 84.62 (n)
  • 84.19 (a)
TRIML1 37
  • 83 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Triml1 36
  • 80.17 (n)
  • 80.82 (a)
Triml1 16
Triml1 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 36 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 39 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
-- 37
  • 39 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 32 (a)
OneToMany
-- 37
  • 34 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 35 (a)
OneToMany
-- 37
  • 42 (a)
OneToMany
-- 37
  • 44 (a)
OneToMany
-- 37
  • 38 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 37 (a)
OneToMany
-- 37
  • 30 (a)
OneToMany
-- 37
  • 36 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
-- 37
  • 40 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 37 (a)
OneToMany
-- 37
  • 33 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
-- 37
  • 41 (a)
OneToMany
-- 37
  • 43 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Triml1 36
  • 80.1 (n)
  • 81.25 (a)
Species with no ortholog for TRIML1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIML1 Gene

ENSEMBL:
Gene Tree for TRIML1 (if available)
TreeFam:
Gene Tree for TRIML1 (if available)

Paralogs for TRIML1 Gene

genes like me logo Genes that share paralogs with TRIML1: view

Variants for TRIML1 Gene

Sequence variations from dbSNP and Humsavar for TRIML1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs6553159 -- 188,137,356(+) ggagt(A/G)cagtg intron-variant
rs6553160 -- 188,141,060(+) GGTCA(C/T)GGACT intron-variant
rs6553161 -- 188,141,161(+) TTGAA(A/T)TCTGT intron-variant
rs6810416 -- 188,145,685(+) cgggc(A/G)tggtg intron-variant
rs6810573 -- 188,136,820(+) GGAGA(C/T)GAATT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIML1 Gene

Variant ID Type Subtype PubMed ID
dgv5855n71 CNV Gain 21882294
nsv523635 CNV Gain 19592680
esv32613 CNV Gain 17666407
nsv880579 CNV Gain 21882294
nsv880478 CNV Loss 21882294
nsv880937 CNV Loss 21882294
nsv10629 CNV Loss 18304495
nsv461870 CNV Gain 19166990
nsv470098 CNV Gain 18288195
nsv880982 CNV Gain 21882294
nsv881101 CNV Gain 21882294
dgv332n21 CNV Loss 19592680
nsv880458 CNV Gain 21882294
nsv830173 CNV Gain 17160897
nsv519300 CNV Gain+Loss 19592680
nsv880723 CNV Gain 21882294
nsv509029 CNV Insertion 20534489
nsv4653 CNV Loss 18451855
nsv4655 CNV Insertion 18451855
nsv881676 CNV Gain 21882294

Relevant External Links for TRIML1 Gene

HapMap Linkage Disequilibrium report
TRIML1

Disorders for TRIML1 Gene

Relevant External Links for TRIML1

Genetic Association Database (GAD)
TRIML1
genes like me logo Genes that share disorders with TRIML1: view

No data available for UniProtKB/Swiss-Prot for TRIML1 Gene

Publications for TRIML1 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Characterization and potential function of a novel pre-implantation embryo-specific RING finger protein: TRIML1. (PMID: 19156909) Tian L. … Chen H. (Mol. Reprod. Dev. 2009) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TRIML1 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIML1
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIML1
    • Block miRNA regulation of TRIML1 using miScript Target Protectors

    Sources for TRIML1 Gene

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