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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM9 Gene

protein-coding   GIFtS: 57
GCID: GC14M051441

tripartite motif containing 9

(Previous name: tripartite motif-containing 9 )
 Explore 7 diseases affiliated with
TRIM9 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM9    

Aliases
for TRIM9 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 91 2     RING Finger Protein 912 3
RNF911 2 3     KIAA02823 5
SPRING1 2 5     E3 Ubiquitin-Protein Ligase TRIM92
Tripartite Motif-Containing 91 2     Homolog Of Rat RING Finger Spring2
Tripartite Motif-Containing Protein 92 3     EC 6.3.2.-3

External Ids:    HGNC: 162881   Entrez Gene: 1140882   Ensembl: ENSG000001005057   OMIM: 6065555   UniProtKB: Q9C0263   

Export aliases for TRIM9 gene to outside databases

Previous GC identifers: GC14M048763 GC14M045237 GC14M049432 GC14M050511 GC14M031567


Summaries
for TRIM9 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for TRIM9:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to
cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript
variants encoding different isoforms. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and
serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may
also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a
regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation

Gene Wiki entry for TRIM9


Genomic Views
for TRIM9 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM9 gene promoter:
         NF-AT4   NRSF form 1   NRSF form 2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TRIM9 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q21.3

TRIM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M051441:  view genomic region     (about GC identifiers)

Start:
 51,441,979 bp from pter      End:
 51,562,779 bp from pter
Size:
 120,801 bases      Orientation:
 minus strand

Proteins
for TRIM9 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM9  
Size: 710 amino acids; 79177 Da
Subunit: Interacts with SNAP25 (By similarity)
Subcellular location: Cytoplasm. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
(By similarity). Cell junction, synapse (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Enriched at
synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the
cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus,
and Purkinje cells in the cerebellum
Sequence caution: Sequence=AAG53490.1; Type=Frameshift; Positions=660; Sequence=AAG53492.1; Type=Frameshift;
Positions=655; Sequence=BAA13398.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA13398.2; Type=Frameshift; Positions=660;
1 PDB 3D structure from and Proteopedia for TRIM9:
2DB8 (3D)    
Secondary accessions: D3DSB7 D3DSB8 Q92557 Q96D24 Q96NI4 Q9C025 Q9C027
Alternative splicing: 3 isoforms:  Q9C026-1   Q9C026-4   Q9C026-5   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for TRIM9: NX_Q9C026

Post-translational modifications:

  • Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9C026

    • TRIM9 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_055978.4  NP_443210.1  

    ENSEMBL proteins: 
     ENSP00000298355   ENSP00000342970   ENSP00000353561  
    Reactome Protein details: Q9C026
    Human Recombinant Protein Products: 
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    Novus Biologicals TRIM9 Protein
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    Uscn Proteins for TRIM9

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA--
    GO:0005856cytoskeleton IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0030054cell junction IEA--
    GO:0030425dendrite IDA--


    TRIM9 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for TRIM9

    Protein Domains /
    Families
    for TRIM9 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM9 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain

    Graphical View of Domain Structure for InterPro Entry Q9C026

    ProtoNet protein and cluster: Q9C026

    3 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Domain: The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25 (By similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM9 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and
    serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may
    also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a
    regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmid: TRIM9 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0008270zinc ion binding IEA--
    GO:0042803protein homodimerization activity IPI11331580


    TRIM9 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for TRIM9:
     Decreased viability of wild-ty 


    Pathways & Interactions
    for TRIM9 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Antigen processing: Ubiquitination & Proteasome degradation
    		Antigen processing: Ubiquitination & Proteasome degradation1.00
    		Polyubiquitination of substrate0.75
    		Class I MHC mediated antigen processing & presentation0.83
    2Immune System
    		Immune System1.00
    		Adaptive Immune System0.59

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    5        Reactome Pathways for TRIM9
        Antigen processing: Ubiquitination & Proteasome degradation
    Polyubiquitination of substrate
    Adaptive Immune System
    Class I MHC mediated antigen processing & presentation
    Immune System


    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Pathway: Protein modification; protein ubiquitination


    TRIM9 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/20 Interacting proteins for TRIM9 (Q9C0262, 3 ENSP000002983554) via UniProtKB, MINT, STRING, and/or I2D (see all 20)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-68269 I2D: score=4 STRING: ENSP00000359206
    NCF1P145982, 3, ENSP000002894734MINT-66383 I2D: score=4 STRING: ENSP00000289473
    VASPP505522, 3, ENSP000002459324MINT-67679 I2D: score=4 STRING: ENSP00000245932
    DTNBP1Q96EV83, ENSP000003416804I2D: score=1 STRING: ENSP00000341680
    SNAP25P608803, ENSP000002549764I2D: score=3 STRING: ENSP00000254976
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0016567protein ubiquitination ----
    GO:0035544negative regulation of SNARE complex assembly IEA--
    GO:0043161proteasomal ubiquitin-dependent protein catabolic process IDA--
    GO:0045955negative regulation of calcium ion-dependent exocytosis IEA--


    TRIM9 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM9 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM9
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    Transcripts
    for TRIM9 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM9 gene (2 alternative transcripts): 
    NM_015163.5  NM_052978.4  

    Unigene Cluster for TRIM9:

    Tripartite motif containing 9
    Hs.654750  [show with all ESTs]
    Unigene Representative Sequence: BC063872
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298355(uc001wyx.4) ENST00000338969(uc001wyy.2) ENST00000555170
    ENST00000557456 ENST00000555933 ENST00000360392(uc001wyz.4)

    miRNA
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    8/91 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM9 (see all 91):
    hsa-miR-3194-5p hsa-miR-134 hsa-miR-30d hsa-miR-30a hsa-miR-409-5p hsa-miR-4325 hsa-miR-3170 hsa-miR-490-5p
    SwitchGear 3'UTR luciferase reporter plasmid: TRIM9 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM9 (see all 7)
    OriGene shRNA RFP: TRIM9
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    Clone
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    Additional cDNA sequence: 

    AK055388.1 BC013414.2 BC063872.1 D87458.2 

    9 DOTS entries:

    DT.416020  DT.100724134  DT.441166  DT.91890097  DT.120765803  DT.40213379  DT.95288719  DT.100802636 
    DT.92421547 

    24/151 AceView cDNA sequences (see all 151):

    CR594583 F01522 BQ189716 H40757 AI360233 AA679797 BQ184373 AW005439 
    F13239 AV702229 CK300843 AI051264 AI823962 BF528171 BF108416 NM_015163 
    BX115829 AL708176 BF059340 AI656763 AI333004 BX953012 BC063872 AK054781 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM9 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
    SP1:                                      -                 -     -     -                       -     -     -                                 
    SP2:                                                        -     -     -     -     -     -     -     -     -                       -         
    SP3:                                                                                                                                          
    SP4:                                                                    -                                                                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for TRIM9

    Expression
    for TRIM9 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TAGTTTACAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM9 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    6 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneMaxillary ProcessBone
    BrainCerebral CortexBrain
    BrainMedulla OblongataBrain
    BrainThalamusBrain
    Neural TubeMetencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Early limb mesenchymal cells (ELM cells) (Primary Cell)Bone, Cartilage, Limb
    Late limb mesenchymal cells (LLM cells) (Primary Cell)Bone, Cartilage, Limb
    Sclerotome cells (Primary Cell)Bone, Cartilage, Somite

    See TRIM9 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM9

    SOURCE GeneReport for Unigene cluster: Hs.654750

    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Tissue specificity: Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the
    affected brain areas in Parkinson disease and dementia with Lewy bodies

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM9: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    Orthologs
    for TRIM9 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIM9 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRIM96
    		 Uncharacterized protein
    		 92(a)
    		 1 ↔ 1
    		 5(60559797-60569727)
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM96
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343527.1(380344-483857)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia AL972955.12   -- 83.18(n)    AL972955.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii trim91 tripartite motif-containing 9 75.39(n)
    84.88(a)    		   336099  NM_205563.1  NP_991126.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Trim91 CG31721-PA 55.42(n)
    47.61(a)    		   34453  NM_001201857.1  NP_001188786.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea C39F7.23
    trim-91    		 Protein TRIM-91 37(a)3
    51.25(n)1
    43.47(a)1    		   V(1223876-1235264)3
    1786191  NM_070994.41  NP_503395.11 


    ENSEMBL Gene Tree for TRIM9 (if available)
    TreeFam Gene Tree for TRIM9 (if available) 

    Paralogs
    for TRIM9 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM9 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM672  TRIM362  MID22  
    MID12  TRIM552  TRIM542  FSD12  
    1 SIMAP similar gene for TRIM9 using alignment to 1 protein entry:     TRIM9_HUMAN:
    TRIM67

    TRIM9 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM9 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2278 NCBI SNPs in TRIM9 are shown (see all 2278)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1386209501,2
    		--51441486(+) AGGCCG/TAGACG 1 -- int10--------
    rs732888101,2
    		C,--51441528(+) TCCTGG/ACCAAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1435644081,2
    		--51441603(+) TAGTCC/TCAGCT 1 -- int10--------
    rs1480294031,2
    		--51441613(+) TACCCA/GGGAGG 1 -- int10--------
    rs118474121,2
    		C,F,H,--51441621(+) aggctG/Aaggca 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1850769031,2
    		--51441636(+) AATTGC/TTTGAA 1 -- int10--------
    rs1895968051,2
    		--51441695(+) GCCTGA/GTGACA 1 -- int10--------
    rs667934541,2
    		C--51441717(+) AAAAA-/AAAAAAAA 1 -- int12Minor allele frequency- AAA:0.25NA 4
    rs80192421,2
    		C,--51441728(+) aaaaaA/Caaaaa 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs128947861,2
    		C,F,A,H,--51441771(+) CCCCAG/AACATC 1 -- int111Minor allele frequency- A:0.07NS EA NA WA CSA 770

    HapMap Linkage Disequilibrium report for TRIM9 (51441979 - 51562779 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIM9
         1 Indel: 11725

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for TRIM9 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM9 for disorders           About GeneDecksing

    OMIM gene information: 606555    OMIM disorders: --

    7 diseases for TRIM9:    About MalaCards
    endocarditis    rabies    parkinson's disease    dementia
    cerebritis    schizophrenia    neuronitis

    Human Genome Epidemiology (HuGE) Navigator: TRIM9 (1 document)

    Export disorders for TRIM9 gene to outside databases

    Publications
    for TRIM9 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM9 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TRIM9)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
    2. TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies. (PubMed id 20085810)1, 2 Tanji K....Wakabayashi K. (2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    6. Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. (PubMed id 11524423)1, 3 Li Y....Li L. (2001)
    7. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
    8. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    9. Functional interactions between ubiquitin E2 enzymes a nd TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (2011)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    External Searches for TRIM9 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TRIM9 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 114088 HGNC: 16288 AceView: TRIM9 Ensembl:ENSG00000100505 euGenes: HUgn114088
    ECgene: TRIM9 H-InvDB: TRIM9

    Other Databases showing TRIM9 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA0282

    Specialized Databases showing TRIM9 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM9 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TRIM9 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TRIM9 gene:
    Search GeneIP for patents involving TRIM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
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    About This Section

     
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