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TRIM9 Gene

protein-coding   GIFtS: 60
GCID: GC14M051441

Tripartite Motif Containing 9

(Previous name: tripartite motif-containing 9)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 91 2     SPRING2 5
Tripartite Motif-Containing 91 2     KIAA02823 5
Tripartite Motif-Containing Protein 92 3     E3 Ubiquitin-Protein Ligase TRIM92
RNF912 3     Homolog Of Rat RING Finger Spring2
RING Finger Protein 912 3     EC 6.3.2.-3

External Ids:    HGNC: 162881   Entrez Gene: 1140882   Ensembl: ENSG000001005057   OMIM: 6065555   UniProtKB: Q9C0263   

Export aliases for TRIM9 gene to outside databases

Previous GC identifers: GC14M048763 GC14M045237 GC14M049432 GC14M050511 GC14M031567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM9 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes
to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two
transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM9 Gene:
TRIM9 (tripartite motif containing 9) is a protein-coding gene. GO annotations related to this gene include SNARE binding and protein homodimerization activity. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and
serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and
may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act
as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex
formation

Gene Wiki entry for TRIM9 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM9 gene promoter:
         NF-AT4   NRSF form 1   NRSF form 2   Roaz   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM9 promoter sequence
   Search Chromatin IP Primers for TRIM9

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM9


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.1   Ensembl cytogenetic band:  14q22.1   HGNC cytogenetic band: 14q21.3

TRIM9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM9 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M051441:  view genomic region     (about GC identifiers)

Start:
51,441,979 bp from pter      End:
51,562,779 bp from pter
Size:
120,801 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM9  
Size: 710 amino acids; 79177 Da
Subunit: Interacts with SNAP25 (By similarity)
Sequence caution: Sequence=AAG53490.1; Type=Frameshift; Positions=660; Sequence=AAG53492.1; Type=Frameshift;
Positions=655; Sequence=BAA13398.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA13398.2; Type=Frameshift; Positions=660;
1 PDB 3D structure from and Proteopedia for TRIM9:
2DB8 (3D)    
Secondary accessions: D3DSB7 D3DSB8 Q92557 Q96D24 Q96NI4 Q9C025 Q9C027
Alternative splicing: 3 isoforms:  Q9C026-1   Q9C026-4   Q9C026-5   (May be due to intron retention)

Explore the universe of human proteins at neXtProt for TRIM9: NX_Q9C026

Explore proteomics data for TRIM9 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM9 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_055978.4  NP_443210.1  

    ENSEMBL proteins: 
     ENSP00000298355   ENSP00000342970   ENSP00000353561  
    Reactome Protein details: Q9C026

    TRIM9 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIM9

     
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    antibodies-online proteins for TRIM9 (6 products) 

     
    antibodies-online peptides for TRIM9

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    FN3: Fibronectin type III domain containing
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 12):
     IPR003649 Bbox_C
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain

    Graphical View of Domain Structure for InterPro Entry Q9C026

    ProtoNet protein and cluster: Q9C026

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003649 B-box


    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Domain: The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25 (By
    similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM9           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIM9_HUMAN, Q9C026
    Function: E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and
    serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and
    may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act
    as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex
    formation

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000149SNARE binding IEA--
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0042803protein homodimerization activity IPI11331580
         
    Find genes that share ontologies with TRIM9           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIM9:
     Decreased viability of wild-ty 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRIM9

    miRNA
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    miRTarBase miRNAs that target TRIM9:
    hsa-mir-1 (MIRT023786), hsa-mir-335-5p (MIRT017814)

    Block miRNA regulation of human, mouse, rat TRIM9 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM9 (see all 91):
    hsa-miR-3194-5p hsa-miR-134 hsa-miR-30d hsa-miR-30a hsa-miR-409-5p hsa-miR-4325 hsa-miR-3170 hsa-miR-490-5p
    SwitchGear 3'UTR luciferase reporter plasmidTRIM9 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM9

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    Browse Sino Biological Human cDNA Clones
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    Addgene plasmids for TRIM9 

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRIM9_HUMAN, Q9C026: Cytoplasm. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic
    vesicle (By similarity). Cell junction, synapse (By similarity). Cytoplasm, cytoskeleton (By similarity).
    Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form.
    Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the
    cerebral cortex and hippocampus, and Purkinje cells in the cerebellum
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton2
    nucleus2

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA11331580
    GO:0005856cytoskeleton IEA--
    GO:0008021synaptic vesicle IEA--
    GO:0030054cell junction IEA--

    Find genes that share ontologies with TRIM9           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM9 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84


    Find genes that share SuperPaths with TRIM9           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIM9
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM9: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM9

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TRIM9 (Q9C0262, 3 ENSP000002983554) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BTRCQ9Y2972, 3, ENSP000003592064MINT-68269 I2D: score=4 STRING: ENSP00000359206
    NCF1P145982, 3, ENSP000002894734MINT-66383 I2D: score=4 STRING: ENSP00000289473
    VASPP505522, 3, ENSP000002459324MINT-67679 I2D: score=4 STRING: ENSP00000245932
    DTNBP1Q96EV83, ENSP000003416804I2D: score=1 STRING: ENSP00000341680
    SNAP25P608803, ENSP000002549764I2D: score=3 STRING: ENSP00000254976
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016079synaptic vesicle exocytosis IEA--
    GO:0035544negative regulation of SNARE complex assembly IEA--
    GO:0043161proteasome-mediated ubiquitin-dependent protein catabolic process IDA--
    GO:0045955negative regulation of calcium ion-dependent exocytosis IEA--

    Find genes that share ontologies with TRIM9           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for TRIM9



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM9 gene (2 alternative transcripts): 
    NM_015163.5  NM_052978.4  

    Unigene Cluster for TRIM9:

    Tripartite motif containing 9
    Hs.654750  [show with all ESTs]
    Unigene Representative Sequence: BC063872
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000298355(uc001wyx.4) ENST00000338969(uc001wyy.2) ENST00000555170
    ENST00000557456 ENST00000555933 ENST00000360392(uc001wyz.4)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIM9 (see all 91):
    hsa-miR-3194-5p hsa-miR-134 hsa-miR-30d hsa-miR-30a hsa-miR-409-5p hsa-miR-4325 hsa-miR-3170 hsa-miR-490-5p
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      QuantiTect SYBR Green Assays in human, mouse, rat TRIM9
      QuantiFast Probe-based Assays in human, mouse, rat TRIM9

    Additional mRNA sequence: 

    AK055388.1 BC013414.2 BC063872.1 D87458.2 

    9 DOTS entries:

    DT.416020  DT.100724134  DT.441166  DT.91890097  DT.120765803  DT.40213379  DT.95288719  DT.100802636 
    DT.92421547 

    Selected AceView cDNA sequences (see all 151):

    H40757 AA679797 BQ184373 BF108416 BF059340 AL708176 AI656763 AK054781 
    F01522 CR594583 BQ189716 BC063872 NM_015163 BX115829 AI360233 BX953012 
    AI333004 AV702229 F13239 CK300843 BF528171 AW005439 AI823962 AI051264 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM9 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
    SP1:                                      -                 -     -     -                       -     -     -                                 
    SP2:                                                        -     -     -     -     -     -     -     -     -                       -         
    SP3:                                                                                                                                          
    SP4:                                                                    -                                                                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for TRIM9

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM9 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGTTTACAC
    TRIM9 Expression
    About this image


    TRIM9 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Mature Endothelial Cells Blood Brain Barrier
             Cerebral Cortex
     
     Neural Tube (Nervous System)    fully expand to see all 3 entries
             Metencephalon
     
     Endothelium (Cardiovascular System)
             Mature Endothelial Cells Blood Brain Barrier
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Lower Urinary Tract (Urinary System)
             Ureter
    TRIM9 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM9 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.654750

    UniProtKB/Swiss-Prot: TRIM9_HUMAN, Q9C026
    Tissue specificity: Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the
    affected brain areas in Parkinson disease and dementia with Lewy bodies

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM9: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM9

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM9 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim91 , 5 tripartite motif-containing 91, 5 90.73(n)1
    97.75(a)1
      12 (29.07 cM)5
    940901  NM_001286388.11  NP_001273317.11 
     702445395 
    chicken
    (Gallus gallus)
    Aves TRIM96
    tripartite motif containing 9
    79(a)
    1 ↔ 1
    5(57866100-57897874)
    lizard
    (Anolis carolinensis)
    Reptilia TRIM96
    tripartite motif containing 9
    68(a)
    1 ↔ 1
    GL343527.1(380344-483857)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL972955.12   -- 83.18(n)    AL972955.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim91 tripartite motif-containing 9 75.39(n)
    84.88(a)
      336099  NM_205563.1  NP_991126.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trim91 Trim9 55.52(n)
    47.55(a)
      34453  NM_001201857.2  NP_001188786.1 
    worm
    (Caenorhabditis elegans)
    Secernentea C39F7.23
    trim-91
    trim-91 37(a)3
    50.76(n)1
    43.32(a)1
      V(1223876-1235264)3
    1786191  NM_070994.51  NP_503395.11 


    ENSEMBL Gene Tree for TRIM9 (if available)
    TreeFam Gene Tree for TRIM9 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM9 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM672  TRIM362  TRIM552  
    MID12  MID22  TRIM542  FSD12  
    1 SIMAP similar gene for TRIM9 using alignment to 1 protein entry:     TRIM9_HUMAN:
    TRIM67

    Find genes that share paralogs with TRIM9           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM9 (see all 2675)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1386209501,2
    --51441486(+) AGGCCG/TAGACG 1 -- int10--------
    rs732888101,2
    C,F--51441528(+) TCCTGG/ACCAAC 1 -- int11Minor allele frequency- A:0.50WA 2
    rs1435644081,2
    C--51441603(+) TAGTCC/TCAGCT 1 -- int10--------
    rs1480294031,2
    --51441613(+) TACCCA/GGGAGG 1 -- int10--------
    rs118474121,2
    C,F,H--51441621(+) aggctG/Aaggca 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1850769031,2
    --51441636(+) AATTGC/TTTGAA 1 -- int10--------
    rs1895968051,2
    --51441695(+) GCCTGA/GTGACA 1 -- int10--------
    rs80192421,2
    C,F--51441728(+) aaaaaA/Caaaaa 1 -- int12Minor allele frequency- C:0.04CSA WA 120
    rs667934541,2
    C--51441732(+) AAAAA-/AAACAGAA 1 -- int11Minor allele frequency- AAA:0.00NA 2
    rs128947861,2
    C,F,A,H--51441771(+) CCCCAG/AACATC 1 -- int111Minor allele frequency- A:0.07NS EA NA WA CSA 770

    HapMap Linkage Disequilibrium report for TRIM9 (51441979 - 51562779 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM9:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv84409CNV Loss16902084

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM9
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM9

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606555    OMIM disorders: --


    Find genes that share disorders with TRIM9           About GenesLikeMe

    Genetic Association Database (GAD): TRIM9
    Human Genome Epidemiology (HuGE) Navigator: TRIM9 (1 document)

    Export disorders for TRIM9 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM9 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TRIM9)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies. (PubMed id 20085810)1, 2 Tanji K....Wakabayashi K. (Neurobiol. Dis. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. (PubMed id 11524423)1, 3 Li Y....Li L. (J. Biol. Chem. 2001)
    8. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (DNA Res. 1997)
    9. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    10. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 114088 HGNC: 16288 AceView: TRIM9 Ensembl:ENSG00000100505 euGenes: HUgn114088
    ECgene: TRIM9 H-InvDB: TRIM9

    (According to HUGE)
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    HUGE: KIAA0282

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM9 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM9 gene:
    Search GeneIP for patents involving TRIM9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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