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Aliases for TRIM9 Gene

Aliases for TRIM9 Gene

  • Tripartite Motif Containing 9 2 3
  • Tripartite Motif-Containing Protein 9 3 4
  • Tripartite Motif-Containing 9 2 3
  • RING Finger Protein 91 3 4
  • KIAA0282 4 6
  • SPRING 3 6
  • RNF91 3 4
  • E3 Ubiquitin-Protein Ligase TRIM9 3
  • Homolog Of Rat RING Finger Spring 3
  • EC 6.3.2.- 4

External Ids for TRIM9 Gene

Previous GeneCards Identifiers for TRIM9 Gene

  • GC14M048763
  • GC14M045237
  • GC14M049432
  • GC14M050511
  • GC14M051441
  • GC14M031567

Summaries for TRIM9 Gene

Entrez Gene Summary for TRIM9 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. Its function has not been identified. Alternate splicing of this gene generates two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM9 Gene

TRIM9 (Tripartite Motif Containing 9) is a Protein Coding gene. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include protein homodimerization activity and SNARE binding. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM9 Gene

  • E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.

Gene Wiki entry for TRIM9 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM9 Gene

Genomics for TRIM9 Gene

Regulatory Elements for TRIM9 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM9 Gene

Start:
50,975,261 bp from pter
End:
51,096,061 bp from pter
Size:
120,801 bases
Orientation:
Minus strand

Genomic View for TRIM9 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM9 Gene

Proteins for TRIM9 Gene

  • Protein details for TRIM9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C026-TRIM9_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM9
    Protein Accession:
    Q9C026
    Secondary Accessions:
    • D3DSB7
    • D3DSB8
    • Q92557
    • Q96D24
    • Q96NI4
    • Q9C025
    • Q9C027

    Protein attributes for TRIM9 Gene

    Size:
    710 amino acids
    Molecular mass:
    79177 Da
    Quaternary structure:
    • Interacts with SNAP25.
    SequenceCaution:
    • Sequence=AAG53490.1; Type=Frameshift; Positions=660; Evidence={ECO:0000305}; Sequence=AAG53492.1; Type=Frameshift; Positions=655; Evidence={ECO:0000305}; Sequence=BAA13398.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAA13398.2; Type=Frameshift; Positions=660; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM9 Gene

    Alternative splice isoforms for TRIM9 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM9 Gene

Proteomics data for TRIM9 Gene at MOPED

Post-translational modifications for TRIM9 Gene

  • Auto-ubiquitinated. Poly-ubiquitinated in cultured cells, whereas it is monoubiquitinated in vitro.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM9 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM9 Gene

Domains for TRIM9 Gene

Gene Families for TRIM9 Gene

HGNC:
  • FN3 :Fibronectin type III domain containing
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM9 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C026

UniProtKB/Swiss-Prot:

TRIM9_HUMAN :
  • Q9C026
Domain:
  • The coiled coil domain mediates the interaction with the N-terminal t-SNARE domain of SNAP25.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM9: view

Function for TRIM9 Gene

Molecular function for TRIM9 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.

Enzyme Numbers (IUBMB) for TRIM9 Gene

Gene Ontology (GO) - Molecular Function for TRIM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000149 SNARE binding IEA --
GO:0004842 ubiquitin-protein transferase activity IDA 20085810
GO:0005515 protein binding IPI 16189514
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM9: view

Phenotypes for TRIM9 Gene

genes like me logo Genes that share phenotypes with TRIM9: view

Animal Model Products

miRNA for TRIM9 Gene

miRTarBase miRNAs that target TRIM9

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM9

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM9 Gene

Localization for TRIM9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM9 Gene

Cytoplasm. Cell projection, dendrite. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Cell junction, synapse. Cytoplasm, cytoskeleton. Note=Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM9 Gene COMPARTMENTS Subcellular localization image for TRIM9 gene
Compartment Confidence
cytoskeleton 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TRIM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 11331580
GO:0005856 cytoskeleton IEA --
GO:0008021 synaptic vesicle IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TRIM9: view

Pathways for TRIM9 Gene

genes like me logo Genes that share pathways with TRIM9: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9C026-TRIM9_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016079 synaptic vesicle exocytosis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0035544 negative regulation of SNARE complex assembly IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IDA 20085810
GO:0045955 negative regulation of calcium ion-dependent exocytosis IEA --
genes like me logo Genes that share ontologies with TRIM9: view

Transcripts for TRIM9 Gene

Unigene Clusters for TRIM9 Gene

Tripartite motif containing 9:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM9

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM9 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b · 11c ^ 12a · 12b ^ 13a · 13b · 13c ^ 14
SP1: - - - - - - -
SP2: - - - - - - - - - -
SP3:
SP4: -
SP5:
SP6:

Relevant External Links for TRIM9 Gene

GeneLoc Exon Structure for
TRIM9
ECgene alternative splicing isoforms for
TRIM9

Expression for TRIM9 Gene

mRNA expression in normal human tissues for TRIM9 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM9 Gene

This gene is overexpressed in Brain - Cerebellum (8.6), Brain - Cerebellar Hemisphere (7.7), Brain - Cortex (4.6), and Brain - Frontal Cortex (BA9) (4.2).

Protein differential expression in normal tissues for TRIM9 Gene

This gene is overexpressed in Platelet (51.0) and Fetal Brain (11.3).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM9 Gene

SOURCE GeneReport for Unigene cluster for TRIM9 Gene Hs.654750

mRNA Expression by UniProt/SwissProt for TRIM9 Gene

Q9C026-TRIM9_HUMAN
Tissue specificity: Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies.
genes like me logo Genes that share expressions with TRIM9: view

Expression partners for TRIM9 Gene

In Situ Assay Products

Orthologs for TRIM9 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM9 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM9 35
  • 92.44 (n)
  • 97.75 (a)
TRIM9 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM9 35
  • 93.62 (n)
  • 98.31 (a)
TRIM9 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim9 35
  • 90.73 (n)
  • 97.75 (a)
Trim9 16
Trim9 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM9 35
  • 99.39 (n)
  • 99.72 (a)
TRIM9 36
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim9 35
  • 90.66 (n)
  • 97.89 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM9 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM9 36
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM9 36
  • 79 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM9 36
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim9 35
  • 79.74 (n)
  • 90.55 (a)
zebrafish
(Danio rerio)
Actinopterygii trim9 35
  • 75.39 (n)
  • 84.88 (a)
trim9 36
  • 83 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008750 35
  • 54.6 (n)
  • 50.95 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trim9 35
  • 55.52 (n)
  • 47.55 (a)
Trim9 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea C39F7.2 37
  • 37 (a)
trim-9 35
  • 50.76 (n)
  • 43.32 (a)
trim-9 36
  • 38 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14178 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for TRIM9:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM9 Gene

ENSEMBL:
Gene Tree for TRIM9 (if available)
TreeFam:
Gene Tree for TRIM9 (if available)

Paralogs for TRIM9 Gene

Selected SIMAP similar genes for TRIM9 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM9: view

Variants for TRIM9 Gene

Sequence variations from dbSNP and Humsavar for TRIM9 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs870371 -- 51,022,724(-) GCCCA(C/T)AGCCT intron-variant
rs873913 -- 51,004,874(+) CCCAA(A/G)GTTTC intron-variant
rs873914 -- 51,005,127(+) ACGCA(G/T)GTTTT intron-variant
rs873915 -- 51,005,906(-) AGCTA(A/C)GGATT intron-variant
rs875204 -- 51,027,510(+) GATTC(A/G)CAGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM9 Gene

Variant ID Type Subtype PubMed ID
nsv84409 CNV Loss 16902084

Relevant External Links for TRIM9 Gene

HapMap Linkage Disequilibrium report
TRIM9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM9 Gene

Disorders for TRIM9 Gene

Relevant External Links for TRIM9

Genetic Association Database (GAD)
TRIM9
Human Genome Epidemiology (HuGE) Navigator
TRIM9

No disorders were found for TRIM9 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM9 Gene

Publications for TRIM9 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. Spring, a novel RING finger protein that regulates synaptic vesicle exocytosis. (PMID: 11524423) Li Y. … Li L. (J. Biol. Chem. 2001) 2 3
  3. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PMID: 12168954) Nakajima D. … Nagase T. (DNA Res. 2002) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRIM9 Gene

Sources for TRIM9 Gene

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