Aliases for TRIM8 Gene
External Ids for TRIM8 Gene
Previous HGNC Symbols for TRIM8 Gene
Previous GeneCards Identifiers for TRIM8 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM8 Gene
TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include Craniofrontonasal Dysplasia and Van Der Woude Syndrome. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Interferon gamma signaling. GO annotations related to this gene include protein homodimerization activity and ligase activity.
UniProtKB/Swiss-Prot for TRIM8 Gene
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.