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Aliases for TRIM8 Gene

Aliases for TRIM8 Gene

  • Tripartite Motif Containing 8 2 3 5
  • Glioblastoma-Expressed RING Finger Protein 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM8 3 4
  • Ring Finger Protein 27 2 3
  • RNF27 3 4
  • GERP 3 4
  • Glioblastoma Expressed Ring Finger Protein 2
  • Probable E3 Ubiquitin-Protein Ligase TRIM8 3
  • Tripartite Motif-Containing Protein 8 4
  • Tripartite Motif Protein TRIM8 3
  • Tripartite Motif-Containing 8 2
  • RING Finger Protein 27 4
  • EC 4

External Ids for TRIM8 Gene

Previous HGNC Symbols for TRIM8 Gene

  • RNF27

Previous GeneCards Identifiers for TRIM8 Gene

  • GC10P103297
  • GC10P103638
  • GC10P104535
  • GC10P104068
  • GC10P104395
  • GC10P098038

Summaries for TRIM8 Gene

Entrez Gene Summary for TRIM8 Gene

  • This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]

GeneCards Summary for TRIM8 Gene

TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include Craniofrontonasal Dysplasia and Van Der Woude Syndrome. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM8 Gene

  • Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM8 Gene

Genomics for TRIM8 Gene

Regulatory Elements for TRIM8 Gene

Enhancers for TRIM8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10G102641 1.7 FANTOM5 ENCODE dbSUPER 8.9 +4.8 4811 12.7 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 SFXN2 MFSD13A AS3MT RPEL1 ARL3 TRIM8 C10orf76 NFKB2 WBP1L ENSG00000272933
GH10G102610 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.7 -30.5 -30469 3.8 ZNF263 ZNF639 ZNF133 JUN KLF17 NR2F2 ZNF664 ZNF629 ZNF600 FOS MFSD13A LDB1 TRIM8 NFKB2 RNU6-43P
GH10G102808 0.4 dbSUPER 4.4 +165.7 165726 1.2 ZNF600 WT1 AS3MT BORCS7 TRIM8 RNU6-1231P CYP17A1-AS1
GH10G102595 1.9 FANTOM5 Ensembl ENCODE dbSUPER 0.3 -42.2 -42233 11.2 FOXA2 MLX ARID4B DMAP1 ZNF2 YY1 ZNF766 ZNF143 FOS SP5 MFSD13A SFXN2 ACTR1A SUFU C10orf95 PSD FBXL15 CUEDC2 MIR146B ARL3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM8 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000032775 1497 5201 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1

Genomic Location for TRIM8 Gene

102,642,903 bp from pter
102,658,407 bp from pter
15,505 bases
Plus strand

Genomic View for TRIM8 Gene

Genes around TRIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM8 Gene

Proteins for TRIM8 Gene

  • Protein details for TRIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIM8
    Protein Accession:
    Secondary Accessions:
    • A6NI31
    • Q9C028

    Protein attributes for TRIM8 Gene

    551 amino acids
    Molecular mass:
    61489 Da
    Quaternary structure:
    • Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box. Interacts with HSP90AB1; prevents nucleus translocation of phosphorylated STAT3 and HSP90AB1.

neXtProt entry for TRIM8 Gene

Post-translational modifications for TRIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM8 Gene

Domains & Families for TRIM8 Gene

Gene Families for TRIM8 Gene

Protein Domains for TRIM8 Gene

Suggested Antigen Peptide Sequences for TRIM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The coiled coil domain is required for homodimerization.
  • Belongs to the TRIM/RBCC family.
  • The coiled coil domain is required for homodimerization.
  • The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM8: view

Function for TRIM8 Gene

Molecular function for TRIM8 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Enzyme Numbers (IUBMB) for TRIM8 Gene

Gene Ontology (GO) - Molecular Function for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19549727
GO:0008270 zinc ion binding NAS,IEA 11118312
GO:0016740 transferase activity IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0042803 protein homodimerization activity IPI 11331580
genes like me logo Genes that share ontologies with TRIM8: view
genes like me logo Genes that share phenotypes with TRIM8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM8 Gene

Localization for TRIM8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM8 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005829 cytosol TAS --
GO:0016605 PML body IDA 11331580
genes like me logo Genes that share ontologies with TRIM8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM8 Gene

Pathways & Interactions for TRIM8 Gene

genes like me logo Genes that share pathways with TRIM8: view

Pathways by source for TRIM8 Gene

UniProtKB/Swiss-Prot Q9BZR9-TRIM8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 26347139
GO:0016567 protein ubiquitination IEA --
GO:0019827 stem cell population maintenance IEA --
GO:0032897 negative regulation of viral transcription IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 23077300
genes like me logo Genes that share ontologies with TRIM8: view

No data available for SIGNOR curated interactions for TRIM8 Gene

Drugs & Compounds for TRIM8 Gene

No Compound Related Data Available

Transcripts for TRIM8 Gene

Unigene Clusters for TRIM8 Gene

Tripartite motif containing 8:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP3: -
SP5: - - - -

Relevant External Links for TRIM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM8 Gene

Protein differential expression in normal tissues from HIPED for TRIM8 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM8 Gene

Protein tissue co-expression partners for TRIM8 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM8 Gene:


SOURCE GeneReport for Unigene cluster for TRIM8 Gene:


mRNA Expression by UniProt/SwissProt for TRIM8 Gene:

Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for TRIM8 Gene

  • Nervous system(4.4)
  • Intestine(4.3)
  • Lung(2.8)
  • Kidney(2.3)
  • Eye(2.1)
genes like me logo Genes that share expression patterns with TRIM8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM8 Gene

Orthologs for TRIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM8 34 35
  • 98.85 (n)
(Bos Taurus)
Mammalia TRIM8 34 35
  • 95.95 (n)
(Canis familiaris)
Mammalia TRIM8 34 35
  • 95.34 (n)
(Mus musculus)
Mammalia Trim8 34 16 35
  • 92.98 (n)
(Rattus norvegicus)
Mammalia Trim8 34
  • 92.38 (n)
(Monodelphis domestica)
Mammalia TRIM8 35
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM8 35
  • 86 (a)
(Gallus gallus)
Aves TRIM8 34 35
  • 82.58 (n)
(Anolis carolinensis)
Reptilia TRIM8 35
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim8 34
  • 75.86 (n)
Str.12777 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.15672 34
(Danio rerio)
Actinopterygii trim8 34
  • 70.73 (n)
trim8b 35
  • 67 (a)
trim8a 35
  • 62 (a)
btr31 35
  • 30 (a)
TRIM8 (2 of 4) 35
  • 17 (a)
wufc90g07 34
Species where no ortholog for TRIM8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM8 Gene

Gene Tree for TRIM8 (if available)
Gene Tree for TRIM8 (if available)

Paralogs for TRIM8 Gene

(2) SIMAP similar genes for TRIM8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM8: view

No data available for Paralogs for TRIM8 Gene

Variants for TRIM8 Gene

Sequence variations from dbSNP and Humsavar for TRIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs386352377 Uncertain significance 102,657,259(+) TGGCG(G/T)TCAGA nc-transcript-variant, reference, missense
rs1000204894 -- 102,649,477(+) GGGCC(C/T)CTGCC intron-variant
rs1000353444 -- 102,643,234(+) GGACC(G/T)GGGTG upstream-variant-2KB
rs1000497655 -- 102,654,909(+) ATGCT(A/G)GCCCA intron-variant
rs1000753162 -- 102,642,725(+) GACGG(G/T)GACGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM8 Gene

Variant ID Type Subtype PubMed ID
nsv1118184 CNV deletion 24896259
nsv831968 CNV gain 17160897
nsv831969 CNV loss 17160897

Variation tolerance for TRIM8 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM8 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM8 Gene

Disorders for TRIM8 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM8 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
craniofrontonasal dysplasia
  • craniofrontonasal syndrome
van der woude syndrome
  • myopathy, actin, congenital, with excess of thin myofilaments
- elite association - COSMIC cancer census association via MalaCards
Search TRIM8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIM8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM8 Gene

Publications for TRIM8 Gene

  1. A novel RING finger-B box-coiled-coil protein, GERP. (PMID: 11118312) Vincent S.R. … Fretier P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 64
  2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E. … Rothman P. (J. Biol. Chem. 2002) 2 3 64
  5. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4 64

Products for TRIM8 Gene

Sources for TRIM8 Gene

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