Aliases for TRIM8 Gene
External Ids for TRIM8 Gene
Previous HGNC Symbols for TRIM8 Gene
Previous GeneCards Identifiers for TRIM8 Gene
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
GeneCards Summary for TRIM8 Gene
TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include van der woude syndrome. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include protein homodimerization activity and ligase activity.
UniProtKB/Swiss-Prot for TRIM8 Gene
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.