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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM8 Gene

protein-coding   GIFtS: 51
GCID: GC10P104395

Tripartite Motif Containing 8

(Previous names: ring finger protein 27, tripartite motif-containing 8)
(Previous symbol: RNF27)
Alzheimer's & Parkinson's Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 81 2     Glioblastoma-Expressed RING Finger Protein2 3
RNF271 2 3 5     Tripartite Motif-Containing Protein 82 3
RING Finger Protein 271 2 3     Probable E3 Ubiquitin-Protein Ligase TRIM82
GERP2 3 5     Tripartite Motif Protein TRIM82
Tripartite Motif-Containing 81 2     EC 6.3.2.-3
Glioblastoma Expressed Ring Finger Protein1 2     

External Ids:    HGNC: 155791   Entrez Gene: 816032   Ensembl: ENSG000001712067   OMIM: 6061255   UniProtKB: Q9BZR93   

Export aliases for TRIM8 gene to outside databases

Previous GC identifers: GC10P103297 GC10P103638 GC10P104535 GC10P104068 GC10P098038


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM8 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes
to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus
thought to contain tumor suppressor genes. (provided by RefSeq, Jul 2008)

GeneCards Summary for TRIM8 Gene: 
TRIM8 (tripartite motif containing 8) is a protein-coding gene. Diseases associated with TRIM8 include glioblastoma, and anaplastic oligodendroglioma. GO annotations related to this gene include protein homodimerization activity and ligase activity. An important paralog of this gene is TRIM25.

UniProtKB/Swiss-Prot: TRIM8_HUMAN, Q9BZR9
Function: Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000010.10  NT_030059.13  NC_018921.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM8 gene promoter:
         Elk-1   MyoD   Lmo2   E47   N-Myc   COMP1   FOXJ2 (long isoform)   Hand1   Pax-4a   Hlf   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM8 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM8

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q24.3   Ensembl cytogenetic band:  10q24.32   HGNC cytogenetic band: 10q24.3

TRIM8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM8 gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10P104395:  view genomic region     (about GC identifiers)

Start:
104,404,252 bp from pter      End:
104,418,076 bp from pter
Size:
13,825 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRIM8_HUMAN, Q9BZR9 (See protein sequence)
Recommended Name: Probable E3 ubiquitin-protein ligase TRIM8  
Size: 551 amino acids; 61489 Da
Subunit: Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity)
Secondary accessions: A6NI31 Q9C028

Explore the universe of human proteins at neXtProt for TRIM8: NX_Q9BZR9

Explore proteomics data for TRIM8 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BZR9

  • TRIM8 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM8 Protein Expression
    REFSEQ proteins: NP_112174.2  
    ENSEMBL proteins: 
     ENSP00000302120   ENSP00000473428  

    Human Recombinant Protein Products for TRIM8: 
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    Novus Biologicals TRIM8 Protein
    Novus Biologicals TRIM8 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016605PML body IDA11331580
    GO:0043231intracellular membrane-bounded organelle IDA--

    TRIM8 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9BZR9

    ProtoNet protein and cluster: Q9BZR9

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRIM8_HUMAN, Q9BZR9
    Domain: The coiled coil domain is required for homodimerization
    Domain: The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1
    (By similarity)
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    TRIM8 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRIM8_HUMAN, Q9BZR9
    Function: Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1 (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding NAS11118312
    GO:0016874ligase activity IEA--
    GO:0042802identical protein binding IPI--
    GO:0042803protein homodimerization activity IPI11331580
         
    TRIM8 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM8:
     Decreased cilium length after   Increased cell death HMECs cel 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM8 
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    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM8 (see all 24):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTRIM8 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM8


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: TRIM8_HUMAN, Q9BZR9
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for TRIM8 (Q9BZR91, 3 ENSP000003021204) via UniProtKB, MINT, STRING, and/or I2D (see all 44)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    UBE2D3P610773, ENSP000003497224I2D: score=2 STRING: ENSP00000349722
    UBE2L6O149333, ENSP000002871564I2D: score=2 STRING: ENSP00000287156
    UBE2V1Q134043, ENSP000003403054I2D: score=2 STRING: ENSP00000340305
    UBE2WQ96B023, ENSP000003974534I2D: score=2 STRING: ENSP00000397453
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--
    GO:0016567protein ubiquitination IEA--

    TRIM8 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM8

    Search CenterWatch for drugs/clinical trials and news about TRIM8

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM8 gene: 
    NM_030912.2  

    Unigene Cluster for TRIM8:

    Tripartite motif containing 8
    Hs.336810  [show with all ESTs]
    Unigene Representative Sequence: NM_030912
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000302424(uc001kvz.2) ENST00000462202 ENST00000487927 ENST00000479004


    miRNA
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM8 (see all 24):
    hsa-miR-302d hsa-miR-520e hsa-miR-520d-5p hsa-miR-106a hsa-miR-302e hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTRIM8 3' UTR sequence
    Inhib. RNA
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM8
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM8 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM8 
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    OriGene qPCR primer pairs and template standards for TRIM8
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM8

    Additional mRNA sequence: 

    AF086326.1 AF220034.1 AF281046.1 AL360160.1 BC021925.1 

    7 DOTS entries:

    DT.314765  DT.91888461  DT.121297195  DT.121297274  DT.95293939  DT.121297278  DT.95293931 

    24/304 AceView cDNA sequences (see all 304):

    BF063049 AI570558 AL360160 AW052168 BI966848 BF431853 CD675739 AA977677 
    AI925572 BF439377 BC021925 BU731945 BG830262 AI470001 BQ188026 BF590251 
    AA559004 BU676749 BM977137 AA807622 AW044255 AI830869 BF055074 AW444940 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM8    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
    SP1:              -     -                             -                     
    SP2:                                                                        
    SP3:                    -                                                   
    SP4:                                                                        
    SP5:              -     -     -     -                                       


    ECgene alternative splicing isoforms for TRIM8

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCGCAGT
    TRIM8 Expression
    About this image


    See TRIM8 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM8

    SOURCE GeneReport for Unigene cluster: Hs.336810

    UniProtKB/Swiss-Prot: TRIM8_HUMAN, Q9BZR9
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM8: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM8

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM8 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim81 , 5 tripartite motif-containing 81, 5 92.98(n)1
    97.64(a)1
      19 (38.92 cM)5
    936791  NM_053100.21  NP_444330.21 
     465016485 
    chicken
    (Gallus gallus)
    Aves TRIM81 tripartite motif containing 8 82.58(n)
    85.12(a)
      423864  NM_001031233.1  NP_001026404.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM86
    Uncharacterized protein
    86(a)
    1 ↔ 1
    3(39878404-39961650)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.156722 Xenopus laevis transcribed sequence with moderate similarity more 77.35(n)    CA788108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii wufc90g072 Transcribed sequence with weak similarity to protein more 73.18(n)    BM025175.1 


    ENSEMBL Gene Tree for TRIM8 (if available)
    TreeFam Gene Tree for TRIM8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM8 gene
    TRIM252  TRIM292  TRIM16L2  TRIM472  TRIM162  TRIM652  
    2 SIMAP similar genes for TRIM8 using alignment to 3 protein entries:     TRIM8_HUMAN (see all proteins):
    TRIM26    TRIM39

    TRIM8 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/317 SNPs in TRIM8 are shown (see all 317)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1807951101,2
    --104402652(+) ATACGC/G/TAGGTA 1 -- us2k10--------
    rs1873760361,2
    --104402654(+) ACGCAA/GGTATT 1 -- us2k10--------
    rs1922753421,2
    --104402856(+) AGACAA/GACGGA 1 -- us2k10--------
    rs120986611,2
    C,F,H--104403103(+) CCCACC/AAAAAA 1 -- us2k13Minor allele frequency- A:0.01NS NA 272
    rs79081901,2
    C,H--104403120(+) AAAAAA/GAATCA 1 -- us2k1 trp30--------
    rs1819235931,2
    --104403200(+) ATGGCA/TGGGCG 1 -- us2k10--------
    rs284086821,2
    C,F--104403310(+) TGGGGG/AGGAGG 1 -- us2k1 trp31Minor allele frequency- A:0.00NA 2
    rs1447280211,2
    C--104403563(+) GGCTT-/CTCC  
            
    CTCCC
    1 -- us2k10--------
    rs1428439001,2
    C--104404159(+) GCTCG-/GGAGGAGG 1 -- cds10--------
    rs1167425591,2
    F--104404215(+) TCCCTC/TCTCCG 1 -- us2k11Minor allele frequency- T:0.07WA 118

    HapMap Linkage Disequilibrium report for TRIM8 (104404252 - 104418076 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM8:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv895980CNV Loss21882294
    nsv831969CNV Loss17160897
    nsv831968CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM8
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM8

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606125    OMIM disorders: --

    5 diseases for TRIM8:    About MalaCards
    glioblastoma    anaplastic oligodendroglioma    oligodendroglioma    alzheimer's disease
    squamous cell carcinoma


    TRIM8 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015
    Genetic Association Database (GAD): TRIM8
    Human Genome Epidemiology (HuGE) Navigator: TRIM8 (1 document)

    Export disorders for TRIM8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM8 gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with TRIM8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel RING finger-B box-coiled-coil protein, GERP. (PubMed id 11118312)1, 2, 3 Vincent S.R.... Fretier P. (2000)
    2. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PubMed id 16385451)1, 4 Grupe A....Goate A. (2006)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. TRIM8/GERP RING finger protein interacts with SOCS-1. (PubMed id 12163497)1, 3 Toniato E....Rothman P. (2002)
    5. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2 Reymond A.... Ballabio A. (2001)
    6. Identification of 23 new prostate cancer susceptibilit y loci using the iCOGS custom genotyping array. (PubMed id 23535732)1 Eeles R.A....Easton D.F. (2013)
    7. Nucleo-cytoplasmic trafficking of TRIM8, a novel oncog ene, is involved in positive regulation of TNF induced NF-kB pathway. (PubMed id 23152791)1 Tomar D....Singh R. (2012)
    8. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    9. TRIM8 modulates p53 activity to dictate cell cycle arr est. (PubMed id 22262183)1 Caratozzolo M.F....Tullo A. (2012)
    10. Intersectin (ITSN) family of scaffolds function as mol ecular hubs in protein interaction networks. (PubMed id 22558309)1 Wong K.A....O'Bryan J.P. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81603 HGNC: 15579 AceView: TRIM8 Ensembl:ENSG00000171206 euGenes: HUgn81603
    ECgene: TRIM8 H-InvDB: TRIM8

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM8 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM8 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM8 gene:
    Search GeneIP for patents involving TRIM8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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