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Aliases for TRIM8 Gene

Aliases for TRIM8 Gene

  • Tripartite Motif Containing 8 2 3 5
  • Glioblastoma Expressed Ring Finger Protein 2 3
  • Glioblastoma-Expressed RING Finger Protein 3 4
  • Tripartite Motif-Containing Protein 8 3 4
  • Tripartite Motif-Containing 8 2 3
  • Ring Finger Protein 27 2 3
  • RNF27 3 4
  • GERP 3 4
  • Tripartite Motif Protein TRIM8 3
  • RING Finger Protein 27 4
  • EC 6.3.2.- 4

External Ids for TRIM8 Gene

Previous HGNC Symbols for TRIM8 Gene

  • RNF27

Previous GeneCards Identifiers for TRIM8 Gene

  • GC10P103297
  • GC10P103638
  • GC10P104535
  • GC10P104068
  • GC10P104395
  • GC10P098038

Summaries for TRIM8 Gene

Entrez Gene Summary for TRIM8 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM8 Gene

TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include van der woude syndrome. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM8 Gene

  • Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM8 Gene

Genomics for TRIM8 Gene

Regulatory Elements for TRIM8 Gene

Promoters for TRIM8 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM8 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM8 Gene

Chromosome:
10
Start:
102,642,903 bp from pter
End:
102,658,407 bp from pter
Size:
15,505 bases
Orientation:
Plus strand

Genomic View for TRIM8 Gene

Genes around TRIM8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM8 Gene

Proteins for TRIM8 Gene

  • Protein details for TRIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZR9-TRIM8_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIM8
    Protein Accession:
    Q9BZR9
    Secondary Accessions:
    • A6NI31
    • Q9C028

    Protein attributes for TRIM8 Gene

    Size:
    551 amino acids
    Molecular mass:
    61489 Da
    Quaternary structure:
    • Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity).

neXtProt entry for TRIM8 Gene

Proteomics data for TRIM8 Gene at MOPED

Post-translational modifications for TRIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM8 Gene

Domains & Families for TRIM8 Gene

Gene Families for TRIM8 Gene

Protein Domains for TRIM8 Gene

Suggested Antigen Peptide Sequences for TRIM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BZR9

UniProtKB/Swiss-Prot:

TRIM8_HUMAN :
  • The coiled coil domain is required for homodimerization.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Domain:
  • The coiled coil domain is required for homodimerization.
  • The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM8: view

Function for TRIM8 Gene

Molecular function for TRIM8 Gene

UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Enzyme Numbers (IUBMB) for TRIM8 Gene

Gene Ontology (GO) - Molecular Function for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 11331580
genes like me logo Genes that share ontologies with TRIM8: view
genes like me logo Genes that share phenotypes with TRIM8: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM8 Gene

Localization for TRIM8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM8 Gene COMPARTMENTS Subcellular localization image for TRIM8 gene
Compartment Confidence
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016605 PML body IDA 11331580
genes like me logo Genes that share ontologies with TRIM8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM8 Gene

Pathways & Interactions for TRIM8 Gene

genes like me logo Genes that share pathways with TRIM8: view

Pathways by source for TRIM8 Gene

UniProtKB/Swiss-Prot Q9BZR9-TRIM8_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 26347139
GO:0019827 stem cell population maintenance IEA --
GO:0045087 innate immune response IEA,IDA 18248090
GO:0046597 negative regulation of viral entry into host cell IEA --
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM8: view

No data available for SIGNOR curated interactions for TRIM8 Gene

Drugs & Compounds for TRIM8 Gene

No Compound Related Data Available

Transcripts for TRIM8 Gene

Unigene Clusters for TRIM8 Gene

Tripartite motif containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2:
SP3: -
SP4:
SP5: - - - -

Relevant External Links for TRIM8 Gene

GeneLoc Exon Structure for
TRIM8
ECgene alternative splicing isoforms for
TRIM8

Expression for TRIM8 Gene

mRNA expression in normal human tissues for TRIM8 Gene

Protein differential expression in normal tissues from HIPED for TRIM8 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM8 Gene



SOURCE GeneReport for Unigene cluster for TRIM8 Gene Hs.336810

mRNA Expression by UniProt/SwissProt for TRIM8 Gene

Q9BZR9-TRIM8_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TRIM8: view

Protein tissue co-expression partners for TRIM8 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM8 Gene

Orthologs for TRIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM8 35
  • 95.95 (n)
  • 99.27 (a)
TRIM8 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM8 35
  • 95.34 (n)
  • 98.73 (a)
TRIM8 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim8 35
  • 92.98 (n)
  • 97.64 (a)
Trim8 16
Trim8 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM8 35
  • 98.85 (n)
  • 98.72 (a)
TRIM8 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim8 35
  • 92.38 (n)
  • 97.82 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM8 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM8 36
  • 86 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM8 35
  • 82.58 (n)
  • 85.12 (a)
TRIM8 36
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM8 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12777 35
trim8 35
  • 75.86 (n)
  • 84.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15672 35
zebrafish
(Danio rerio)
Actinopterygii trim8 35
  • 70.73 (n)
  • 70.61 (a)
wufc90g07 35
btr31 36
  • 30 (a)
OneToMany
TRIM8 (2 of 4) 36
  • 17 (a)
OneToMany
trim8a 36
  • 62 (a)
OneToMany
trim8b 36
  • 67 (a)
OneToMany
Species with no ortholog for TRIM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM8 Gene

ENSEMBL:
Gene Tree for TRIM8 (if available)
TreeFam:
Gene Tree for TRIM8 (if available)

Paralogs for TRIM8 Gene

(2) SIMAP similar genes for TRIM8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM8: view

No data available for Paralogs for TRIM8 Gene

Variants for TRIM8 Gene

Sequence variations from dbSNP and Humsavar for TRIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs4146426 -- 102,644,578(+) TGGGG(A/T)GTCGG utr-variant-5-prime
rs4146428 -- 102,641,964(+) GCTCA(A/G)TTCCA upstream-variant-2KB
rs4146429 -- 102,641,875(+) CTTGC(C/T)AGGTA upstream-variant-2KB
rs5011218 -- 102,641,461(+) ATAAT(A/C)TATAA upstream-variant-2KB
rs7922780 -- 102,641,446(+) taagc(A/G)tacta upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM8 Gene

Variant ID Type Subtype PubMed ID
nsv831968 CNV Gain 17160897
nsv895980 CNV Loss 21882294
nsv831969 CNV Loss 17160897

Variation tolerance for TRIM8 Gene

Residual Variation Intolerance Score: 13.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.01; 37.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM8 Gene

HapMap Linkage Disequilibrium report
TRIM8
Human Gene Mutation Database (HGMD)
TRIM8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM8 Gene

Disorders for TRIM8 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
van der woude syndrome
  • myopathy, actin, congenital, with excess of thin myofilaments
- elite association - COSMIC cancer census association via MalaCards
Search TRIM8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIM8

Genetic Association Database (GAD)
TRIM8
Human Genome Epidemiology (HuGE) Navigator
TRIM8
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM8
genes like me logo Genes that share disorders with TRIM8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM8 Gene

Publications for TRIM8 Gene

  1. A novel RING finger-B box-coiled-coil protein, GERP. (PMID: 11118312) Vincent S.R. … Fretier P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4 67
  2. TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E. … Rothman P. (J. Biol. Chem. 2002) 2 3
  3. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  4. TRIM8 anti-proliferative action against chemo-resistant renal cell carcinoma. (PMID: 25277184) Caratozzolo M.F. … Tullo A. (Oncotarget 2014) 3
  5. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 3

Products for TRIM8 Gene

Sources for TRIM8 Gene

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