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Aliases for TRIM8 Gene

Aliases for TRIM8 Gene

  • Tripartite Motif Containing 8 2 3
  • RNF27 3 4 6
  • GERP 3 4 6
  • Glioblastoma Expressed Ring Finger Protein 2 3
  • Glioblastoma-Expressed RING Finger Protein 3 4
  • Tripartite Motif-Containing Protein 8 3 4
  • Tripartite Motif-Containing 8 2 3
  • Ring Finger Protein 27 2 3
  • Probable E3 Ubiquitin-Protein Ligase TRIM8 3
  • Tripartite Motif Protein TRIM8 3
  • RING Finger Protein 27 4
  • EC 6.3.2.- 4

External Ids for TRIM8 Gene

Previous HGNC Symbols for TRIM8 Gene

  • RNF27

Previous GeneCards Identifiers for TRIM8 Gene

  • GC10P103297
  • GC10P103638
  • GC10P104535
  • GC10P104068
  • GC10P104395
  • GC10P098038

Summaries for TRIM8 Gene

Entrez Gene Summary for TRIM8 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM8 Gene

TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include glioblastoma. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM8 Gene

  • Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM8 Gene

Genomics for TRIM8 Gene

Regulatory Elements for TRIM8 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM8 Gene

102,643,425 bp from pter
102,658,407 bp from pter
14,983 bases
Plus strand

Genomic View for TRIM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM8 Gene

Proteins for TRIM8 Gene

  • Protein details for TRIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIM8
    Protein Accession:
    Secondary Accessions:
    • A6NI31
    • Q9C028

    Protein attributes for TRIM8 Gene

    551 amino acids
    Molecular mass:
    61489 Da
    Quaternary structure:
    • Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity).

neXtProt entry for TRIM8 Gene

Proteomics data for TRIM8 Gene at MOPED

Post-translational modifications for TRIM8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM8 Gene

Domains for TRIM8 Gene

Gene Families for TRIM8 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM8 Gene

Suggested Antigen Peptide Sequences for TRIM8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9BZR9
  • The coiled coil domain is required for homodimerization
  • The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM8: view

Function for TRIM8 Gene

Molecular function for TRIM8 Gene

UniProtKB/Swiss-Prot Function:
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Enzyme Numbers (IUBMB) for TRIM8 Gene

Gene Ontology (GO) - Molecular Function for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding NAS 11118312
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0042803 protein homodimerization activity IPI 11331580
genes like me logo Genes that share ontologies with TRIM8: view

Phenotypes for TRIM8 Gene

genes like me logo Genes that share phenotypes with TRIM8: view

Animal Model Products

miRNA for TRIM8 Gene

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM8

In Situ Assay Products

Flow Cytometry Products

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM8 Gene

Localization for TRIM8 Gene

Subcellular locations from

Jensen Localization Image for TRIM8 Gene COMPARTMENTS Subcellular localization image for TRIM8 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016605 PML body IDA 11331580
genes like me logo Genes that share ontologies with TRIM8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM8 Gene

Pathways for TRIM8 Gene

SuperPathways for TRIM8 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BZR9-TRIM8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 23077300
GO:0045087 innate immune response IDA 18248090
genes like me logo Genes that share ontologies with TRIM8: view

No data available for Pathways by source for TRIM8 Gene

Transcripts for TRIM8 Gene

Unigene Clusters for TRIM8 Gene

Tripartite motif containing 8:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM8

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP3: -
SP5: - - - -

Relevant External Links for TRIM8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM8 Gene

mRNA expression in normal human tissues for TRIM8 Gene

Protein differential expression in normal tissues for TRIM8 Gene

This gene is overexpressed in Lung (62.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM8 Gene

SOURCE GeneReport for Unigene cluster for TRIM8 Gene Hs.336810

mRNA Expression by UniProt/SwissProt for TRIM8 Gene

Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with TRIM8: view

Expression partners for TRIM8 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM8 Gene

Orthologs for TRIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM8 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM8 35
  • 95.95 (n)
  • 99.27 (a)
TRIM8 36
  • 99 (a)
(Canis familiaris)
Mammalia TRIM8 35
  • 95.34 (n)
  • 98.73 (a)
TRIM8 36
  • 99 (a)
(Mus musculus)
Mammalia Trim8 35
  • 92.98 (n)
  • 97.64 (a)
Trim8 16
Trim8 36
  • 97 (a)
(Pan troglodytes)
Mammalia TRIM8 35
  • 98.85 (n)
  • 98.72 (a)
TRIM8 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim8 35
  • 92.38 (n)
  • 97.82 (a)
(Monodelphis domestica)
Mammalia TRIM8 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM8 36
  • 86 (a)
(Gallus gallus)
Aves TRIM8 35
  • 82.58 (n)
  • 85.12 (a)
TRIM8 36
  • 85 (a)
(Anolis carolinensis)
Reptilia TRIM8 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12777 35
trim8 35
  • 75.86 (n)
  • 84.03 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15672 35
(Danio rerio)
Actinopterygii trim8 35
  • 70.73 (n)
  • 70.61 (a)
wufc90g07 35
btr31 36
  • 30 (a)
TRIM8 (2 of 4) 36
  • 17 (a)
trim8a 36
  • 62 (a)
trim8b 36
  • 67 (a)
Species with no ortholog for TRIM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM8 Gene

Gene Tree for TRIM8 (if available)
Gene Tree for TRIM8 (if available)

Paralogs for TRIM8 Gene

Selected SIMAP similar genes for TRIM8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM8: view

No data available for Paralogs for TRIM8 Gene

Variants for TRIM8 Gene

Sequence variations from dbSNP and Humsavar for TRIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1063241 -- 102,655,179(+) TAGAC(A/T)AGGCC reference, stop-gained
rs2286747 -- 102,654,880(+) TGCCC(A/G)TGGAT intron-variant
rs2286748 -- 102,654,952(+) TCAGA(A/C)CTTGC intron-variant
rs3217079 -- 102,656,054(+) CCGGG(-/CTCTCCCTGGA)ACTGC intron-variant
rs3850699 -- 102,654,464(-) TCCCA(C/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM8 Gene

Variant ID Type Subtype PubMed ID
nsv831968 CNV Gain 17160897
nsv895980 CNV Loss 21882294
nsv831969 CNV Loss 17160897

Relevant External Links for TRIM8 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM8 Gene

Disorders for TRIM8 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for TRIM8 Gene in MalaCards »

(1) Diseases for TRIM8 Gene including...

Relevant External Links for TRIM8

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TRIM8: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM8 Gene

Publications for TRIM8 Gene

  1. A novel RING finger-B box-coiled-coil protein, GERP. (PMID: 11118312) Vincent S.R. … Fretier P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4
  3. TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E. … Rothman P. (J. Biol. Chem. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 48

Products for TRIM8 Gene

Sources for TRIM8 Gene

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