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Aliases for TRIM8 Gene

Aliases for TRIM8 Gene

  • Tripartite Motif Containing 8 2 3
  • RNF27 3 4 6
  • GERP 3 4 6
  • Glioblastoma Expressed Ring Finger Protein 2 3
  • Glioblastoma-Expressed RING Finger Protein 3 4
  • Tripartite Motif-Containing Protein 8 3 4
  • Tripartite Motif-Containing 8 2 3
  • Ring Finger Protein 27 2 3
  • Probable E3 Ubiquitin-Protein Ligase TRIM8 3
  • Tripartite Motif Protein TRIM8 3
  • RING Finger Protein 27 4
  • EC 6.3.2.- 4

External Ids for TRIM8 Gene

Previous Symbols for TRIM8 Gene

  • RNF27

Summaries for TRIM8 Gene

Entrez Gene Summary for TRIM8 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to nuclear bodies. Its structure is similar to some tumor suppressor proteins and its gene maps to a locus thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM8 Gene

TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include glioblastoma. GO annotations related to this gene include protein homodimerization activity and ligase activity.

UniProtKB/Swiss-Prot for TRIM8 Gene

  • Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM8 Gene

Genomics for TRIM8 Gene

Genomic Location for TRIM8 Gene

Start:
102,643,425 bp from pter
End:
102,658,407 bp from pter
Size:
14,983 bases
Orientation:
Plus strand

Genomic View for TRIM8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM8 Gene

Regulatory Elements for TRIM8 Gene

Proteins for TRIM8 Gene

  • Protein details for TRIM8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BZR9-TRIM8_HUMAN
    Recommended name:
    Probable E3 ubiquitin-protein ligase TRIM8
    Protein Accession:
    Q9BZR9
    Secondary Accessions:
    • A6NI31
    • Q9C028

    Protein attributes for TRIM8 Gene

    Size:
    551 amino acids
    Molecular mass:
    61489 Da
    Quaternary structure:
    • Homodimer. Interacts with SOCS1 (via) SH2 domain and SOCS box (By similarity).

neXtProt entry for TRIM8 Gene

Proteomics data for TRIM8 Gene at MOPED

Post-translational modifications for TRIM8 Gene

No Post-translational modifications

Other Protein References for TRIM8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM8 Gene

Domains for TRIM8 Gene

Gene Families for TRIM8 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM8 Gene

UniProtKB/Swiss-Prot:

TRIM8_HUMAN
Domain:
  • The coiled coil domain is required for homodimerization:
    • Q9BZR9
  • The region immediately C-terminal to the RING motif is sufficient to mediate the interaction with SOCS1.:
    • Q9BZR9
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9BZR9
Similarity:
  • Contains 2 B box-type zinc fingers.:
    • Q9BZR9
  • Contains 1 RING-type zinc finger.:
    • Q9BZR9
genes like me logo Genes that share domains with TRIM8: view

Function for TRIM8 Gene

Molecular function for TRIM8 Gene

UniProtKB/Swiss-Prot Function: Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.

Enzyme Numbers (IUBMB) for TRIM8 Gene

Gene Ontology (GO) - Molecular Function for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding NAS 11118312
GO:0016874 ligase activity IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0042803 protein homodimerization activity IPI 11331580
genes like me logo Genes that share ontologies with TRIM8: view

Phenotypes for TRIM8 Gene

genes like me logo Genes that share phenotypes with TRIM8: view

miRNA for TRIM8 Gene

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM8 Gene

Localization for TRIM8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM8 Gene COMPARTMENTS Subcellular localization image for TRIM8 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016605 PML body IDA 11331580
genes like me logo Genes that share ontologies with TRIM8: view

Pathways for TRIM8 Gene

SuperPathways for TRIM8 Gene

No Data Available

UniProtKB/Swiss-Prot Q9BZR9-TRIM8_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IEA --
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 23077300
GO:0045087 innate immune response IDA 18248090
genes like me logo Genes that share ontologies with TRIM8: view

No data available for Pathways by source for TRIM8 Gene

Transcripts for TRIM8 Gene

Unigene Clusters for TRIM8 Gene

Tripartite motif containing 8:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM8 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b
SP1: - - -
SP2:
SP3: -
SP4:
SP5: - - - -

Relevant External Links for TRIM8 Gene

GeneLoc Exon Structure for
TRIM8
ECgene alternative splicing isoforms for
TRIM8

Expression for TRIM8 Gene

mRNA expression in normal human tissues for TRIM8 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM8 Gene

SOURCE GeneReport for Unigene cluster for TRIM8 Gene Hs.336810

mRNA Expression by UniProt/SwissProt for TRIM8 Gene

Q9BZR9-TRIM8_HUMAN
Tissue specificity: Widely expressed
genes like me logo Genes that share expressions with TRIM8: view

Orthologs for TRIM8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM8 36
  • 98.85 (n)
  • 98.72 (a)
TRIM8 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM8 36
  • 95.95 (n)
  • 99.27 (a)
TRIM8 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM8 36
  • 95.34 (n)
  • 98.73 (a)
TRIM8 37
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim8 36
  • 92.98 (n)
  • 97.64 (a)
Trim8 16
Trim8 37
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM8 37
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM8 37
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim8 36
  • 92.38 (n)
  • 97.82 (a)
chicken
(Gallus gallus)
Aves TRIM8 36
  • 82.58 (n)
  • 85.12 (a)
TRIM8 37
  • 85 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM8 37
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15672 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12777 36
trim8 36
  • 75.86 (n)
  • 84.03 (a)
zebrafish
(Danio rerio)
Actinopterygii btr31 37
  • 30 (a)
OneToMany
trim8 36
  • 70.73 (n)
  • 70.61 (a)
TRIM8 (2 of 4) 37
  • 17 (a)
OneToMany
trim8a 37
  • 62 (a)
OneToMany
trim8b 37
  • 67 (a)
OneToMany
wufc90g07 36
Species with no ortholog for TRIM8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM8 Gene

ENSEMBL:
Gene Tree for TRIM8 (if available)
TreeFam:
Gene Tree for TRIM8 (if available)

Paralogs for TRIM8 Gene

Selected SIMAP similar genes for TRIM8 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM8: view

No data available for Paralogs for TRIM8 Gene

Variants for TRIM8 Gene

Sequence variations from dbSNP and Humsavar for TRIM8 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs1063241 -- 102,655,179(+) TAGAC(A/T)AGGCC reference, stop-gained
rs2286747 -- 102,654,880(+) TGCCC(A/G)TGGAT intron-variant
rs2286748 -- 102,654,952(+) TCAGA(A/C)CTTGC intron-variant
rs3217079 -- 102,656,054(+) CCGGG(-/CTCTCCCTGGA)ACTGC intron-variant
rs3850699 -- 102,654,464(-) TCCCA(C/T)GCATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM8 Gene

Variant ID Type Subtype PubMed ID
nsv831968 CNV Gain 17160897
nsv895980 CNV Loss 21882294
nsv831969 CNV Loss 17160897

Relevant External Links for TRIM8 Gene

HapMap Linkage Disequilibrium report
TRIM8
Human Gene Mutation Database (HGMD)
TRIM8

Disorders for TRIM8 Gene

(1) MalaCards Diseases for TRIM8 Gene

Search for TRIM8 Gene in MalaCards »

Relevant External Links for TRIM8

Genetic Association Database (GAD)
TRIM8
Human Genome Epidemiology (HuGE) Navigator
TRIM8
genes like me logo Genes that share disorders with TRIM8: view

No data available for UniProtKB/Swiss-Prot for TRIM8 Gene

Publications for TRIM8 Gene

  1. A novel RING finger-B box-coiled-coil protein, GERP. (PMID: 11118312) Vincent S.R. … Fretier P. (Biochem. Biophys. Res. Commun. 2000) 2 3 4
  2. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 3 4
  3. TRIM8/GERP RING finger protein interacts with SOCS-1. (PMID: 12163497) Toniato E. … Rothman P. (J. Biol. Chem. 2002) 2 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3 49

Products for TRIM8 Gene

Sources for TRIM8 Gene

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