Aliases for TRIM8 Gene
External Ids for TRIM8 Gene
Previous HGNC Symbols for TRIM8 Gene
Previous GeneCards Identifiers for TRIM8 Gene
This gene encodes a member of the tripartite motif (TRIM) protein family. Based on similarities to other proteins, the encoded protein is suspected to be an E3 ubiquitin-protein ligase. Regulation of this gene may be altered in some cancers. Mutations resulting in a truncated protein product have been observed in early-onset epileptic encephalopathy (EOEE). [provided by RefSeq, Sep 2016]
GeneCards Summary for TRIM8 Gene
TRIM8 (Tripartite Motif Containing 8) is a Protein Coding gene. Diseases associated with TRIM8 include Craniofrontonasal Dysplasia and Van Der Woude Syndrome. Among its related pathways are Interferon gamma signaling and Innate Immune System. GO annotations related to this gene include protein homodimerization activity and ligase activity.
UniProtKB/Swiss-Prot for TRIM8 Gene
Probable E3 ubiquitin-protein ligase which may promote proteasomal degradation of SOCS1.