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Aliases for TRIM74 Gene

Aliases for TRIM74 Gene

  • Tripartite Motif Containing 74 2 3 5
  • Tripartite Motif-Containing Protein 50C 3 4
  • Tripartite Motif-Containing 50C 2 3
  • Tripartite Motif-Containing 74 2 3
  • TRIM50C 3 4

External Ids for TRIM74 Gene

Previous HGNC Symbols for TRIM74 Gene

  • TRIM50C

Previous GeneCards Identifiers for TRIM74 Gene

  • GC07M072067
  • GC07M072430
  • GC07M071762

Summaries for TRIM74 Gene

GeneCards Summary for TRIM74 Gene

TRIM74 (Tripartite Motif Containing 74) is a Protein Coding gene. Diseases associated with TRIM74 include williams-beuren syndrome. An important paralog of this gene is TRIM50.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM74 Gene

Genomics for TRIM74 Gene

Regulatory Elements for TRIM74 Gene

Genomic Location for TRIM74 Gene

Chromosome:
7
Start:
72,954,849 bp from pter
End:
72,969,681 bp from pter
Size:
14,833 bases
Orientation:
Minus strand

Genomic View for TRIM74 Gene

Genes around TRIM74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM74 Gene

Proteins for TRIM74 Gene

  • Protein details for TRIM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UV6-TRI74_HUMAN
    Recommended name:
    Tripartite motif-containing protein 74
    Protein Accession:
    Q86UV6
    Secondary Accessions:
    • B7WP46

    Protein attributes for TRIM74 Gene

    Size:
    250 amino acids
    Molecular mass:
    28547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM74 Gene

Proteomics data for TRIM74 Gene at MOPED

Post-translational modifications for TRIM74 Gene

No Post-translational modifications

Other Protein References for TRIM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM74 Gene

Domains & Families for TRIM74 Gene

Gene Families for TRIM74 Gene

Suggested Antigen Peptide Sequences for TRIM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UV6

UniProtKB/Swiss-Prot:

TRI74_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM74: view

Function for TRIM74 Gene

Gene Ontology (GO) - Molecular Function for TRIM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM74: view

Phenotypes for TRIM74 Gene

genes like me logo Genes that share phenotypes with TRIM74: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM74 Gene

Localization for TRIM74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM74 Gene COMPARTMENTS Subcellular localization image for TRIM74 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM74 Gene

Pathways & Interactions for TRIM74 Gene

SuperPathways for TRIM74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM74 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM74 Gene

Drugs & Compounds for TRIM74 Gene

No Compound Related Data Available

Transcripts for TRIM74 Gene

mRNA/cDNA for TRIM74 Gene

Unigene Clusters for TRIM74 Gene

Tripartite motif containing 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM74 Gene

No ASD Table

Relevant External Links for TRIM74 Gene

GeneLoc Exon Structure for
TRIM74
ECgene alternative splicing isoforms for
TRIM74

Expression for TRIM74 Gene

mRNA expression in normal human tissues for TRIM74 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM74 Gene

This gene is overexpressed in Stomach (x6.9) and Testis (x4.1).

SOURCE GeneReport for Unigene cluster for TRIM74 Gene Hs.645328

genes like me logo Genes that share expression patterns with TRIM74: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM74 Gene

Orthologs for TRIM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM73 35
  • 96.27 (n)
  • 92.8 (a)
TRIM50 36
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRIM50 36
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim50 36
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 7 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 15 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim47 36
  • 12 (a)
ManyToMany
Species with no ortholog for TRIM74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM74 Gene

ENSEMBL:
Gene Tree for TRIM74 (if available)
TreeFam:
Gene Tree for TRIM74 (if available)

Paralogs for TRIM74 Gene

Paralogs for TRIM74 Gene

(4) SIMAP similar genes for TRIM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM74: view

Variants for TRIM74 Gene

Sequence variations from dbSNP and Humsavar for TRIM74 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs121966 - 72,966,121(+) AAGCC(A/G)GTCCT intron-variant, reference, missense
rs236630 -- 72,967,405(-) tggca(C/T)gtgcc intron-variant, upstream-variant-2KB
rs436123 -- 72,966,272(-) TTCCT(A/C)TAAAA intron-variant
rs440856 -- 72,966,866(+) CACTA(C/T)AGCCT intron-variant, utr-variant-5-prime
rs412692 -- 72,958,668(-) GGCAC(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM74 Gene

Variant ID Type Subtype PubMed ID
nsv888381 CNV Gain 21882294
nsv528969 CNV Gain 19592680
dgv2102e1 CNV Complex 17122850
essv14753 CNV CNV 17122850
nsv831035 CNV Loss 17160897

Variation tolerance for TRIM74 Gene

Gene Damage Index Score: 1.10; 22.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM74 Gene

HapMap Linkage Disequilibrium report
TRIM74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM74 Gene

Disorders for TRIM74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM74
genes like me logo Genes that share disorders with TRIM74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM74 Gene

Publications for TRIM74 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3

Products for TRIM74 Gene

Sources for TRIM74 Gene

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