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TRIM74 Gene

protein-coding   GIFtS: 46
GCID: GC07M072430

Tripartite Motif Containing 74

(Previous names: tripartite motif-containing 50C, tripartite motif-containing...)
(Previous symbol: TRIM50C)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 741 2
TRIM50C1 2 3 5
Tripartite Motif-Containing 50C1 2
Tripartite Motif-Containing 741 2
Tripartite Motif-Containing Protein 50C2 3
Tripartite Motif-Containing Protein 742

External Ids:    HGNC: 174531   Entrez Gene: 3781082   Ensembl: ENSG000001554287   OMIM: 6125505   UniProtKB: Q86UV63   

Export aliases for TRIM74 gene to outside databases

Previous GC identifers: GC07M072067 GC07M071762


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIM74 Gene:
TRIM74 (tripartite motif containing 74) is a protein-coding gene. Diseases associated with TRIM74 include williams-beuren syndrome. An important paralog of this gene is TRIM31.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM74 gene promoter:
         SRF   Brachyury   SRF (504 AA)   SREBP-1c   AP-4   Tal-1beta   E47   SREBP-1b   c-Rel   SREBP-1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 7): TRIM74 promoter sequence
   Search Chromatin IP Primers for TRIM74

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM74


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q11.23   Ensembl cytogenetic band:  7q11.23   HGNC cytogenetic band: 7q11.23

TRIM74 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM74 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M072430:  view genomic region     (about GC identifiers)

Start:
72,430,016 bp from pter      End:
72,439,997 bp from pter
Size:
9,982 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 71,762,838-71,772,819     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI74_HUMAN, Q86UV6 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 74  
Size: 250 amino acids; 28547 Da
Secondary accessions: B7WP46
Alternative splicing: 2 isoforms:  Q86UV6-1   Q86UV6-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM74: NX_Q86UV6

Explore proteomics data for TRIM74 at MOPED


See TRIM74 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_942150.1  
ENSEMBL proteins: 
 ENSP00000378665   ENSP00000285805  

TRIM74 Human Recombinant Protein Products:

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
TRIM: Tripartite motif containing / Tripartite motif containing
RNF: RING-type (C3HC4) zinc fingers

5 InterPro protein domains:
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR000315 Znf_B-box
 IPR018957 Znf_C3HC4_RING-type
 IPR013083 Znf_RING/FYVE/PHD

Graphical View of Domain Structure for InterPro Entry Q86UV6

ProtoNet protein and cluster: Q86UV6

2 Blocks protein domains:
IPB000315 B-box zinc finger signature
IPB001841 Zn-finger


UniProtKB/Swiss-Prot: TRI74_HUMAN, Q86UV6
Similarity: Belongs to the TRIM/RBCC family
Similarity: Contains 1 B box-type zinc finger
Similarity: Contains 1 RING-type zinc finger


TRIM74 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 3 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
GO:0046872metal ion binding ----
     
TRIM74 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TRIM74:
 Increased gamma-H2AX phosphory 

Animal Models:
   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM74
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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM74

miRNA
Products:
    
miRTarBase miRNAs that target TRIM74:
hsa-mir-335-5p (MIRT017752)

Block miRNA regulation of human, mouse, rat TRIM74 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate TRIM74:
hsa-miR-3137
SwitchGear 3'UTR luciferase reporter plasmidTRIM74 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for TRIM74
Predesigned siRNA for gene silencing in human, mouse, rat TRIM74

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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM74


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus3
cytosol2

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

TRIM74 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Pathway & Disease-focused RT2 Profiler PCR Array including TRIM74: 
          Ubiquitin Ligases in human mouse rat

Interactions:

    Search GeneGlobe Interaction Network for TRIM74

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

Selected Interacting proteins for TRIM74 (Q86UV63 ENSP000002858054) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
InteractantInteraction Details
GeneCardExternal ID(s)
TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
BRCA1ENSP000003502834STRING: ENSP00000350283
LRSAM1ENSP000003004174STRING: ENSP00000300417
MGRN1ENSP000002623704STRING: ENSP00000262370
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TRIM74 (TRI74)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TRIM74 gene: 
NM_198853.1  

Unigene Cluster for TRIM74:

Tripartite motif containing 74
Hs.645328  [show with all ESTs]
Unigene Representative Sequence: AF498999
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000395244(uc003tws.1) ENST00000285805(uc010lao.2 uc022afm.1)

miRNA
Products:
     
Block miRNA regulation of human, mouse, rat TRIM74 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate TRIM74:
hsa-miR-3137
SwitchGear 3'UTR luciferase reporter plasmidTRIM74 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for TRIM74
Predesigned siRNA for gene silencing in human, mouse, rat TRIM74
Clone
Products:
     
OriGene clones in human, mouse for TRIM74 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector: TRIM74 (NM_198853)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM74
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM74
Primer
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OriGene qSTAR qPCR primer pairs in human, mouse for TRIM74
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM74
  QuantiTect SYBR Green Assays in human, mouse, rat TRIM74
  QuantiFast Probe-based Assays in human, mouse, rat TRIM74

Additional mRNA sequence: 

AF498999.1 BC033871.1 

5 DOTS entries:

DT.100736906  DT.440570  DT.443249  DT.40240037  DT.121116638 

Selected AceView cDNA sequences (see all 203):

BI467255 BX280902 AW072375 NM_148936 BM744483 NM_032158 CA489462 BM822299 
AF498999 AA077613 NM_198853 AW082313 AI912937 AI903913 CB131493 BI824241 
CR621627 AA699788 AI903942 BM773388 BM991054 BF345451 NM_149379 AA601272 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRIM74 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCCTCCAGGT
TRIM74 Expression
About this image

TRIM74 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRIM74 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.645328
    Pathway & Disease-focused RT2 Profiler PCR Array including TRIM74: 
          Ubiquitin Ligases in human mouse rat

Primer
Products:
OriGene qSTAR qPCR primer pairs in human, mouse for TRIM74
Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM74
QuantiTect SYBR Green Assays in human, mouse, rat TRIM74
QuantiFast Probe-based Assays in human, mouse, rat TRIM74
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM74

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TRIM74 gene from Selected species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
26(a)
1 → many
19(291285-295292) ENSGALG00000021696
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
15(a)
many ↔ many
2(194920250-194934269)
zebrafish
(Danio rerio)
Actinopterygii trim476
tripartite motif containing 47
12(a)
many ↔ many
10(26752552-26762609) ENSDARG00000056678
        Species with no ortholog for TRIM74

ENSEMBL Gene Tree for TRIM74 (if available)
TreeFam Gene Tree for TRIM74 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRIM74 gene
TRIM731 2  TRIM312  TRIM502  TRIM102  TRIM692  TRIM152  TRIM262  TRIM352  
TRIM522  TRIM622  TRIM412  TRIM722  
4 SIMAP similar genes for TRIM74 using alignment to 1 protein entry:     TRI74_HUMAN:
TRIM73    TRIM50    TRIM22    TRIM6-TRIM34

TRIM74 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRIM74 (see all 43)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 7 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1436008371,2
--72430260(+) AGGGAC/TGTGAC 1 -- ut310--------
rs2012696471,2
C--72430305(+) CAGCTA/GTAGGC 1 -- ut310--------
rs2020389621,2
C--72430307(+) GCTATA/GGGCAG 1 -- ut310--------
rs1511256891,2
C,F--72430567(+) TCATGG/ATGGTC 2 /H syn11Minor allele frequency- A:0.00NA 4544
rs1903869781,2
--72430579(+) TCATTG/TCCGAA 2 G syn10--------
rs1998872651,2
--72431889(+) GATTCA/GGGTCC 2 R * stg10--------
rs1818379631,2
--72436060(+) AAACAC/GGAAGG 1 -- int10--------
rs2007838991,2
F--72436307(+) GCAGAC/TGGTGG 2 I V mis11Minor allele frequency- T:0.08EU 875
rs1468971491,2
F--72436438(+) GCTCCG/AGGTCC 2 /P /L mis11Minor allele frequency- A:0.00NA 4540
rs1390556381,2
F--72436485(+) GAGACG/ATTGGG 2 /N syn11Minor allele frequency- A:0.00NA 4184

HapMap Linkage Disequilibrium report for TRIM74 (72430016 - 72439997 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TRIM74:    About this table    
Variant IDTypeSubtypePubMed ID
nsv831035CNV Loss17160897
nsv528969CNV Gain19592680
nsv888381CNV Gain21882294
essv14753CNV CNV17122850
dgv2102e1CNV Complex17122850

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing TRIM74
DNA2.0 Custom Variant and Variant Library Synthesis for TRIM74

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 612550    OMIM disorders: --

1 disease for TRIM74:    About MalaCards
williams-beuren syndrome

1 disease from the University of Copenhagen DISEASES database for TRIM74:
Williams-Beuren syndrome

TRIM74 for disorders           About GeneDecksing


Export disorders for TRIM74 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRIM74 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TRIM74)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PubMed id 18398435)1, 2 Micale L.... Reymond A. (Eur. J. Hum. Genet. 2008)
  2. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
  5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
  6. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 378108 HGNC: 17453 AceView: DKFZP434A0131andWBSCR20CandTRIM50C Ensembl:ENSG00000155428 euGenes: HUgn378108
ECgene: TRIM74 H-InvDB: TRIM74

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRIM74 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRIM74 gene:
Search GeneIP for patents involving TRIM74

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

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