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Aliases for TRIM74 Gene

Aliases for TRIM74 Gene

  • Tripartite Motif Containing 74 2 3 5
  • Tripartite Motif-Containing Protein 50C 3 4
  • Tripartite Motif-Containing 50C 2 3
  • TRIM50C 3 4
  • Tripartite Motif-Containing Protein 74 3
  • Tripartite Motif-Containing 74 2

External Ids for TRIM74 Gene

Previous HGNC Symbols for TRIM74 Gene

  • TRIM50C

Previous GeneCards Identifiers for TRIM74 Gene

  • GC07M072067
  • GC07M072430
  • GC07M071762

Summaries for TRIM74 Gene

GeneCards Summary for TRIM74 Gene

TRIM74 (Tripartite Motif Containing 74) is a Protein Coding gene. Diseases associated with TRIM74 include Williams-Beuren Syndrome. An important paralog of this gene is TRIM73.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM74 Gene

Genomics for TRIM74 Gene

Regulatory Elements for TRIM74 Gene

Enhancers for TRIM74 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F072968 0.5 Ensembl 0.8 +0.1 149 1.4 TRIM74 NSUN5P2
GH07F072964 0.2 Ensembl 0.8 +4.1 4081 3.2 NFIA ZNF366 POLR2A SMARCA4 ZNF512 TYW1B TRIM74 NSUN5P2
GH07F072960 0.2 Ensembl 0.4 +8.9 8880 1.6 NSUN5P2 TRIM74
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM74 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM74 Gene

72,954,849 bp from pter
72,969,681 bp from pter
14,833 bases
Minus strand

Genomic View for TRIM74 Gene

Genes around TRIM74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM74 Gene

Proteins for TRIM74 Gene

  • Protein details for TRIM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 74
    Protein Accession:
    Secondary Accessions:
    • B7WP46

    Protein attributes for TRIM74 Gene

    250 amino acids
    Molecular mass:
    28547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM74 Gene


neXtProt entry for TRIM74 Gene

Post-translational modifications for TRIM74 Gene

No Post-translational modifications

Other Protein References for TRIM74 Gene

No data available for DME Specific Peptides for TRIM74 Gene

Domains & Families for TRIM74 Gene

Gene Families for TRIM74 Gene

Suggested Antigen Peptide Sequences for TRIM74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM74: view

Function for TRIM74 Gene

Gene Ontology (GO) - Molecular Function for TRIM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM74: view

Phenotypes for TRIM74 Gene

genes like me logo Genes that share phenotypes with TRIM74: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM74 Gene

Localization for TRIM74 Gene

Subcellular locations from

Jensen Localization Image for TRIM74 Gene COMPARTMENTS Subcellular localization image for TRIM74 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM74: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM74 Gene

Pathways & Interactions for TRIM74 Gene

SuperPathways for TRIM74 Gene

No Data Available

Interacting Proteins for TRIM74 Gene

Gene Ontology (GO) - Biological Process for TRIM74 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM74 Gene

Transcripts for TRIM74 Gene

mRNA/cDNA for TRIM74 Gene

Unigene Clusters for TRIM74 Gene

Tripartite motif containing 74:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM74 Gene

No ASD Table

Relevant External Links for TRIM74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM74 Gene

mRNA expression in normal human tissues for TRIM74 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM74 Gene

This gene is overexpressed in Stomach (x6.9) and Testis (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TRIM74 Gene:


SOURCE GeneReport for Unigene cluster for TRIM74 Gene:

genes like me logo Genes that share expression patterns with TRIM74: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM74 Gene

Orthologs for TRIM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM74 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM73 34
  • 96.27 (n)
TRIM50 35
  • 94 (a)
(Bos Taurus)
Mammalia TRIM50 35
  • 43 (a)
(Canis familiaris)
Mammalia -- 35
  • 43 (a)
(Mus musculus)
Mammalia Trim50 35
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 7 (a)
(Gallus gallus)
Aves -- 35
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 15 (a)
(Danio rerio)
Actinopterygii trim47 35
  • 12 (a)
Species where no ortholog for TRIM74 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM74 Gene

Gene Tree for TRIM74 (if available)
Gene Tree for TRIM74 (if available)

Paralogs for TRIM74 Gene

Paralogs for TRIM74 Gene

(4) SIMAP similar genes for TRIM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM74: view

Variants for TRIM74 Gene

Sequence variations from dbSNP and Humsavar for TRIM74 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10235070 -- 72,982,859(+) ggatc(A/G)cctga intron-variant
rs10235085 -- 72,982,889(+) gcctg(A/G)ccaac intron-variant
rs10240489 -- 72,971,507(+) ACCTT(C/T)TTTGT intron-variant, upstream-variant-2KB
rs10240494 -- 72,971,518(+) CCCTT(C/T)TTACA intron-variant, upstream-variant-2KB
rs10240512 -- 72,971,557(+) GCCTT(C/T)TGAGC intron-variant, nc-transcript-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM74 Gene

Variant ID Type Subtype PubMed ID
dgv6464n100 CNV gain 25217958
esv2759537 CNV gain+loss 17122850
esv2764061 CNV gain+loss 21179565
esv34349 CNV gain 17911159
esv3571921 CNV loss 25503493
esv3613678 CNV loss 21293372
nsv1018175 CNV gain 25217958
nsv1018460 CNV gain+loss 25217958
nsv1023115 CNV gain 25217958
nsv1029162 CNV loss 25217958
nsv1030447 CNV loss 25217958
nsv1161563 CNV deletion 26073780
nsv428171 CNV gain 18775914
nsv469664 CNV loss 16826518
nsv520573 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv607478 CNV loss 21841781
nsv831025 CNV loss 17160897
nsv831035 CNV loss 17160897
nsv970875 CNV duplication 23825009
nsv981535 CNV duplication 23825009

Variation tolerance for TRIM74 Gene

Gene Damage Index Score: 1.10; 22.37% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM74 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM74 Gene

Disorders for TRIM74 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM74 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM74: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM74 Gene

Publications for TRIM74 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4 64
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4 64
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  4. Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. (PMID: 24952745) Arking D.E. … Newton-Cheh C. (Nat. Genet. 2014) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for TRIM74 Gene

Sources for TRIM74 Gene

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