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Aliases for TRIM74 Gene

Aliases for TRIM74 Gene

  • Tripartite Motif Containing 74 2 3
  • TRIM50C 3 4 6
  • Tripartite Motif-Containing Protein 50C 3 4
  • Tripartite Motif-Containing 50C 2 3
  • Tripartite Motif-Containing 74 2 3
  • Tripartite Motif-Containing Protein 74 3

External Ids for TRIM74 Gene

Previous Symbols for TRIM74 Gene

  • TRIM50C

Summaries for TRIM74 Gene

GeneCards Summary for TRIM74 Gene

TRIM74 (Tripartite Motif Containing 74) is a Protein Coding gene. An important paralog of this gene is TRIM50.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM74 Gene

Genomics for TRIM74 Gene

Genomic Location for TRIM74 Gene

Start:
72,954,811 bp from pter
End:
72,969,600 bp from pter
Size:
14,790 bases
Orientation:
Minus strand

Genomic View for TRIM74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM74 Gene

Regulatory Elements for TRIM74 Gene

Proteins for TRIM74 Gene

  • Protein details for TRIM74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UV6-TRI74_HUMAN
    Recommended name:
    Tripartite motif-containing protein 74
    Protein Accession:
    Q86UV6
    Secondary Accessions:
    • B7WP46

    Protein attributes for TRIM74 Gene

    Size:
    250 amino acids
    Molecular mass:
    28547 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM74 Gene

Proteomics data for TRIM74 Gene at MOPED

Post-translational modifications for TRIM74 Gene

No Post-translational modifications

Other Protein References for TRIM74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM74 Gene

Domains for TRIM74 Gene

Gene Families for TRIM74 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI74_HUMAN
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q86UV6
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q86UV6
  • Contains 1 RING-type zinc finger.:
    • Q86UV6
genes like me logo Genes that share domains with TRIM74: view

Function for TRIM74 Gene

Gene Ontology (GO) - Molecular Function for TRIM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM74: view

Phenotypes for TRIM74 Gene

GenomeRNAi human phenotypes for TRIM74:
genes like me logo Genes that share phenotypes with TRIM74: view

miRNA for TRIM74 Gene

miRTarBase miRNAs that target TRIM74

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM74 Gene

Localization for TRIM74 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM74 Gene COMPARTMENTS Subcellular localization image for TRIM74 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM74: view

Pathways for TRIM74 Gene

SuperPathways for TRIM74 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM74 Gene

None

No data available for Pathways by source for TRIM74 Gene

Transcripts for TRIM74 Gene

Unigene Clusters for TRIM74 Gene

Tripartite motif containing 74:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM74 Gene

No ASD Table

Relevant External Links for TRIM74 Gene

GeneLoc Exon Structure for
TRIM74
ECgene alternative splicing isoforms for
TRIM74

Expression for TRIM74 Gene

mRNA expression in normal human tissues for TRIM74 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM74 Gene

This gene is overexpressed in Stomach (6.9) and Testis (4.1).

SOURCE GeneReport for Unigene cluster for TRIM74 Gene Hs.645328

genes like me logo Genes that share expressions with TRIM74: view

Orthologs for TRIM74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM74 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM50 37
  • 94 (a)
OneToMany
TRIM73 36
  • 96.27 (n)
  • 92.8 (a)
cow
(Bos Taurus)
Mammalia TRIM50 37
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim50 37
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 7 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 37
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 15 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim47 37
  • 12 (a)
ManyToMany
Species with no ortholog for TRIM74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM74 Gene

ENSEMBL:
Gene Tree for TRIM74 (if available)
TreeFam:
Gene Tree for TRIM74 (if available)

Paralogs for TRIM74 Gene

Selected SIMAP similar genes for TRIM74 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM74: view

Variants for TRIM74 Gene

Sequence variations from dbSNP and Humsavar for TRIM74 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs412692 -- 72,958,668(-) GGCAC(A/G)AGAAT intron-variant
rs423315 -- 72,966,274(+) TTAGA(A/G)GAAAC intron-variant, upstream-variant-2KB
rs434484 -- 72,965,529(+) AAACA(A/C/G)GAAGG intron-variant
rs436123 -- 72,966,272(-) TTCCT(A/C)TAAAA intron-variant, upstream-variant-2KB
rs3095183 -- 72,961,368(-) GTGAA(A/C)AACCG reference, missense, nc-transcript-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM74 Gene

Variant ID Type Subtype PubMed ID
nsv888381 CNV Gain 21882294
nsv528969 CNV Gain 19592680
dgv2102e1 CNV Complex 17122850
essv14753 CNV CNV 17122850
nsv831035 CNV Loss 17160897

Relevant External Links for TRIM74 Gene

HapMap Linkage Disequilibrium report
TRIM74

Disorders for TRIM74 Gene

(1) University of Copenhagen DISEASES for TRIM74 Gene

genes like me logo Genes that share disorders with TRIM74: view

No data available for UniProtKB/Swiss-Prot for TRIM74 Gene

Publications for TRIM74 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4
  3. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for TRIM74 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM74
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM74
  • Block miRNA regulation of TRIM74 using miScript Target Protectors

Sources for TRIM74 Gene

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