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Aliases for TRIM73 Gene

Aliases for TRIM73 Gene

  • Tripartite Motif Containing 73 2 3 5
  • Tripartite Motif-Containing Protein 50B 3 4
  • TRIM50B 3 4
  • Tripartite Motif-Containing Protein 73 3
  • Tripartite Motif-Containing 50B 2
  • Tripartite Motif-Containing 73 2

External Ids for TRIM73 Gene

Previous HGNC Symbols for TRIM73 Gene

  • TRIM50B

Previous GeneCards Identifiers for TRIM73 Gene

  • GC07P074862
  • GC07P075024
  • GC07P074357

Summaries for TRIM73 Gene

GeneCards Summary for TRIM73 Gene

TRIM73 (Tripartite Motif Containing 73) is a Protein Coding gene. An important paralog of this gene is TRIM74.

Additional gene information for TRIM73 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM73 Gene

Genomics for TRIM73 Gene

Regulatory Elements for TRIM73 Gene

Enhancers for TRIM73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H074635 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 -759.0 -759028 1 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A FOS ZNF202 REST PPARG ZNF623 PMS2P3 STAG3L1 NSUN5P1 MIR590 SPDYE5 METTL27 GTF2IRD2 GTF2IRD2B LOC101926943 BUD23
GH07H075637 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10 +244.3 244316 3 ATF1 ARNT ZNF133 SIN3A GLI4 ZNF2 ZBTB7B ETS1 ZNF766 GLIS2 SPDYE5 HIP1 STAG3L1 PMS2P3 NSUN5P1 GTF2IRD2B GTF2IRD2 LOC101926943 TRIM73 DTX2
GH07H075534 1.1 Ensembl ENCODE 15 +140.2 140179 1 HDAC1 PKNOX1 ATF1 FOXA2 BMI1 BATF FOS ATF7 ETV6 RUNX3 TRIM73 PMS2P3 GC07M075581
GH07H075776 1 Ensembl ENCODE 11.9 +381.6 381553 0 BCOR CTCF ZNF140 ZMYM3 MAX RAD21 ZNF366 POLR2A FOS ATF7 PMS2P3 NSUN5P1 LOC100133091 STAG3L1 SPDYE5 TRIM73 GTF2IRD2 GTF2IRD2B CCL26 HIP1
GH07H076280 1 dbSUPER 10.1 +887.0 887023 2 HDGF ARNT SIN3A YBX1 GLI4 ZNF2 GLIS2 ZNF302 KLF7 ZNF548 STAG3L1 PMS2P3 FAM185BP NSUN5P1 SPDYE18 LOC100422695 SRRM3 DTX2P1 PMS2P9 LOC100133091
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM73 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM73 Gene

Chromosome:
7
Start:
75,395,063 bp from pter
End:
75,410,996 bp from pter
Size:
15,934 bases
Orientation:
Plus strand

Genomic View for TRIM73 Gene

Genes around TRIM73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM73 Gene

Proteins for TRIM73 Gene

  • Protein details for TRIM73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86UV7-TRI73_HUMAN
    Recommended name:
    Tripartite motif-containing protein 73
    Protein Accession:
    Q86UV7
    Secondary Accessions:
    • Q8N0S3

    Protein attributes for TRIM73 Gene

    Size:
    250 amino acids
    Molecular mass:
    28517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM73 Gene

Post-translational modifications for TRIM73 Gene

No Post-translational modifications

Other Protein References for TRIM73 Gene

No data available for DME Specific Peptides for TRIM73 Gene

Domains & Families for TRIM73 Gene

Gene Families for TRIM73 Gene

Suggested Antigen Peptide Sequences for TRIM73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86UV7

UniProtKB/Swiss-Prot:

TRI73_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM73: view

Function for TRIM73 Gene

Phenotypes From GWAS Catalog for TRIM73 Gene

Gene Ontology (GO) - Molecular Function for TRIM73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM73: view

Phenotypes for TRIM73 Gene

genes like me logo Genes that share phenotypes with TRIM73: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM73
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM73 Gene

Localization for TRIM73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM73 gene
Compartment Confidence
cytosol 5
nucleus 3

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with TRIM73: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM73 Gene

Pathways & Interactions for TRIM73 Gene

SuperPathways for TRIM73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM73 Gene

Drugs & Compounds for TRIM73 Gene

No Compound Related Data Available

Transcripts for TRIM73 Gene

mRNA/cDNA for TRIM73 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM73 Gene

Tripartite motif containing 73:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TRIM73
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM73 Gene

No ASD Table

Relevant External Links for TRIM73 Gene

GeneLoc Exon Structure for
TRIM73
ECgene alternative splicing isoforms for
TRIM73

Expression for TRIM73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM73 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM73 Gene:

TRIM73

SOURCE GeneReport for Unigene cluster for TRIM73 Gene:

Hs.632307
genes like me logo Genes that share expression patterns with TRIM73: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM73 Gene

Orthologs for TRIM73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM73 33
  • 96.53 (n)
TRIM50 34
  • 94 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TRIM50 34
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 43 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim50 34
  • 41 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 9 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 26 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 9 (a)
ManyToMany
Species where no ortholog for TRIM73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM73 Gene

ENSEMBL:
Gene Tree for TRIM73 (if available)
TreeFam:
Gene Tree for TRIM73 (if available)

Paralogs for TRIM73 Gene

(15) SIMAP similar genes for TRIM73 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM73: view

Variants for TRIM73 Gene

Sequence variations from dbSNP and Humsavar for TRIM73 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs111656303 -- 75,402,415(+) GAGAC(G/T)GAGTC intron-variant
rs111923502 -- 75,401,667(+) AGTTC(C/T)TCTCA intron-variant
rs112340704 -- 75,399,739(+) TGGTG(C/T)GATCA intron-variant
rs112493146 -- 75,398,245(+) CCCAG(C/T)GGATT intron-variant
rs112728736 -- 75,396,500(+) GCGTA(A/G)GCTAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM73 Gene

Variant ID Type Subtype PubMed ID
dgv6464n100 CNV gain 25217958
esv2759537 CNV gain+loss 17122850
esv2764061 CNV gain+loss 21179565
esv34349 CNV gain 17911159
esv3571921 CNV loss 25503493
esv3613678 CNV loss 21293372
nsv1018175 CNV gain 25217958
nsv1018460 CNV gain+loss 25217958
nsv1023115 CNV gain 25217958
nsv1029162 CNV loss 25217958
nsv1030447 CNV loss 25217958
nsv1161563 CNV deletion 26073780
nsv428171 CNV gain 18775914
nsv469664 CNV loss 16826518
nsv520573 CNV gain+loss 19592680
nsv528969 CNV gain 19592680
nsv607478 CNV loss 21841781
nsv831025 CNV loss 17160897
nsv831035 CNV loss 17160897
nsv970875 CNV duplication 23825009
nsv981535 CNV duplication 23825009

Variation tolerance for TRIM73 Gene

Gene Damage Index Score: 1.51; 29.32% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM73 Gene

Disorders for TRIM73 Gene

Relevant External Links for TRIM73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM73

No disorders were found for TRIM73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM73 Gene

Publications for TRIM73 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L … Reymond A (European journal of human genetics : EJHG 2008) 3 4 60
  2. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 60
  3. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M … Lindquist S (Cell 2012) 3 60
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for TRIM73 Gene

Sources for TRIM73 Gene

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