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Aliases for TRIM73 Gene

Aliases for TRIM73 Gene

  • Tripartite Motif Containing 73 2 3 5
  • Tripartite Motif-Containing Protein 50B 3 4
  • TRIM50B 3 4
  • Tripartite Motif-Containing 50B 2
  • Tripartite Motif-Containing 73 2

External Ids for TRIM73 Gene

Previous HGNC Symbols for TRIM73 Gene

  • TRIM50B

Previous GeneCards Identifiers for TRIM73 Gene

  • GC07P074862
  • GC07P075024
  • GC07P074357

Summaries for TRIM73 Gene

GeneCards Summary for TRIM73 Gene

TRIM73 (Tripartite Motif Containing 73) is a Protein Coding gene. Diseases associated with TRIM73 include Williams-Beuren Syndrome. An important paralog of this gene is TRIM50.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM73 Gene

Genomics for TRIM73 Gene

Regulatory Elements for TRIM73 Gene

Enhancers for TRIM73 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM73 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM73 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM73 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM73 Gene

75,395,063 bp from pter
75,410,996 bp from pter
15,934 bases
Plus strand

Genomic View for TRIM73 Gene

Genes around TRIM73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM73 Gene

Proteins for TRIM73 Gene

  • Protein details for TRIM73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 73
    Protein Accession:
    Secondary Accessions:
    • Q8N0S3

    Protein attributes for TRIM73 Gene

    250 amino acids
    Molecular mass:
    28517 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM73 Gene

Proteomics data for TRIM73 Gene at MOPED

Post-translational modifications for TRIM73 Gene

No Post-translational modifications

Other Protein References for TRIM73 Gene

No data available for DME Specific Peptides for TRIM73 Gene

Domains & Families for TRIM73 Gene

Gene Families for TRIM73 Gene

Suggested Antigen Peptide Sequences for TRIM73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM73: view

Function for TRIM73 Gene

Gene Ontology (GO) - Molecular Function for TRIM73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM73: view

Phenotypes for TRIM73 Gene

GenomeRNAi human phenotypes for TRIM73:
genes like me logo Genes that share phenotypes with TRIM73: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM73 Gene

Localization for TRIM73 Gene

Subcellular locations from

Jensen Localization Image for TRIM73 Gene COMPARTMENTS Subcellular localization image for TRIM73 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM73 Gene

Pathways & Interactions for TRIM73 Gene

SuperPathways for TRIM73 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM73 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM73 Gene

Drugs & Compounds for TRIM73 Gene

No Compound Related Data Available

Transcripts for TRIM73 Gene

mRNA/cDNA for TRIM73 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM73 Gene

Tripartite motif containing 73:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM73 Gene

No ASD Table

Relevant External Links for TRIM73 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM73 Gene

mRNA expression in normal human tissues for TRIM73 Gene

SOURCE GeneReport for Unigene cluster for TRIM73 Gene Hs.632307

genes like me logo Genes that share expression patterns with TRIM73: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM73 Gene

Orthologs for TRIM73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM73 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM73 35
  • 96.53 (n)
  • 93.2 (a)
TRIM50 36
  • 94 (a)
(Bos Taurus)
Mammalia TRIM50 36
  • 43 (a)
(Canis familiaris)
Mammalia -- 36
  • 43 (a)
(Mus musculus)
Mammalia Trim50 36
  • 41 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 9 (a)
(Gallus gallus)
Aves -- 36
  • 26 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 9 (a)
Species with no ortholog for TRIM73:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM73 Gene

Gene Tree for TRIM73 (if available)
Gene Tree for TRIM73 (if available)

Paralogs for TRIM73 Gene

Paralogs for TRIM73 Gene

(15) SIMAP similar genes for TRIM73 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM73: view

Variants for TRIM73 Gene

Sequence variations from dbSNP and Humsavar for TRIM73 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs3095181 -- 75,398,202(+) AGAAG(A/G)AAAGC intron-variant
rs3095182 -- 75,398,315(+) TCTCA(C/T)TGACA intron-variant
rs236634 -- 75,400,267(+) gaggc(C/T)gaggt intron-variant
rs236638 -- 75,405,361(+) GTCAC(A/G)TCCCT utr-variant-3-prime
rs139250213 -- 75,405,036(+) GAACA(A/C/G)TTCGG reference, synonymous-codon, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIM73 Gene

Variant ID Type Subtype PubMed ID
nsv888381 CNV Gain 21882294
nsv528969 CNV Gain 19592680
dgv2102e1 CNV Complex 17122850
essv14753 CNV CNV 17122850
nsv831035 CNV Loss 17160897

Variation tolerance for TRIM73 Gene

Gene Damage Index Score: 1.51; 29.32% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM73 Gene

Disorders for TRIM73 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM73 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM73: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM73 Gene

Publications for TRIM73 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4 67
  2. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for TRIM73 Gene

Sources for TRIM73 Gene