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Aliases for TRIM72 Gene

Aliases for TRIM72 Gene

  • Tripartite Motif Containing 72 2 3
  • Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase 2 3 5
  • Tripartite Motif-Containing 72 2 3
  • Mitsugumin 53 2 3
  • Mitsugumin-53 3 4
  • MG53 3 4

External Ids for TRIM72 Gene

Previous GeneCards Identifiers for TRIM72 Gene

  • GC16P031119
  • GC16P031025
  • GC16P031084
  • GC16P028786

Summaries for TRIM72 Gene

GeneCards Summary for TRIM72 Gene

TRIM72 (Tripartite Motif Containing 72) is a Protein Coding gene. Among its related pathways are Smooth Muscle Contraction and Cardiac conduction. GO annotations related to this gene include phosphatidylserine binding. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM72 Gene

  • Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM72 Gene

Genomics for TRIM72 Gene

Regulatory Elements for TRIM72 Gene

Enhancers for TRIM72 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM72 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM72 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM72 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM72 Gene

Chromosome:
16
Start:
31,214,021 bp from pter
End:
31,231,537 bp from pter
Size:
17,517 bases
Orientation:
Plus strand

Genomic View for TRIM72 Gene

Genes around TRIM72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM72 Gene

Proteins for TRIM72 Gene

  • Protein details for TRIM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMU5-TRI72_HUMAN
    Recommended name:
    Tripartite motif-containing protein 72
    Protein Accession:
    Q6ZMU5
    Secondary Accessions:
    • Q8N4X6
    • Q8NBD9

    Protein attributes for TRIM72 Gene

    Size:
    477 amino acids
    Molecular mass:
    52731 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked. Interacts with DYSF and CAV3 (By similarity).
    SequenceCaution:
    • Sequence=BAC03506.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM72 Gene

    Alternative splice isoforms for TRIM72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM72 Gene

Proteomics data for TRIM72 Gene at MOPED

Post-translational modifications for TRIM72 Gene

  • Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
  • S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM72 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Santa Cruz Biotechnology (SCBT) Antibodies for TRIM72

No data available for DME Specific Peptides for TRIM72 Gene

Domains & Families for TRIM72 Gene

Gene Families for TRIM72 Gene

Suggested Antigen Peptide Sequences for TRIM72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMU5

UniProtKB/Swiss-Prot:

TRI72_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM72: view

Function for TRIM72 Gene

Molecular function for TRIM72 Gene

UniProtKB/Swiss-Prot Function:
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Gene Ontology (GO) - Molecular Function for TRIM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA,IPI 25416956
genes like me logo Genes that share ontologies with TRIM72: view
genes like me logo Genes that share phenotypes with TRIM72: view

Animal Models for TRIM72 Gene

MGI Knock Outs for TRIM72:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM72

miRNA for TRIM72 Gene

miRTarBase miRNAs that target TRIM72

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM72 Gene

Localization for TRIM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM72 Gene

Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM72 Gene COMPARTMENTS Subcellular localization image for TRIM72 gene
Compartment Confidence
plasma membrane 5
nucleus 4
cytosol 2
endoplasmic reticulum 1

No data available for Gene Ontology (GO) - Cellular Components for TRIM72 Gene

Pathways & Interactions for TRIM72 Gene

genes like me logo Genes that share pathways with TRIM72: view

Pathways by source for TRIM72 Gene

2 Reactome pathways for TRIM72 Gene

Gene Ontology (GO) - Biological Process for TRIM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001778 plasma membrane repair ISS --
GO:0003012 muscle system process ISS --
GO:0006887 exocytosis IEA --
GO:0016567 protein ubiquitination IEA --
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process IEA --
genes like me logo Genes that share ontologies with TRIM72: view

No data available for SIGNOR curated interactions for TRIM72 Gene

Drugs & Compounds for TRIM72 Gene

No Compound Related Data Available

Transcripts for TRIM72 Gene

mRNA/cDNA for TRIM72 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM72 Gene

Tripartite motif containing 72:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM72 Gene

No ASD Table

Relevant External Links for TRIM72 Gene

GeneLoc Exon Structure for
TRIM72
ECgene alternative splicing isoforms for
TRIM72

Expression for TRIM72 Gene

mRNA expression in normal human tissues for TRIM72 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM72 Gene

This gene is overexpressed in Muscle - Skeletal (x44.9).

Protein differential expression in normal tissues from HIPED for TRIM72 Gene

This gene is overexpressed in Tonsil (50.3) and Esophagus (11.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM72 Gene



SOURCE GeneReport for Unigene cluster for TRIM72 Gene Hs.661859

genes like me logo Genes that share expression patterns with TRIM72: view

Protein tissue co-expression partners for TRIM72 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM72 Gene

Orthologs for TRIM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM72 35
  • 91.68 (n)
  • 94.71 (a)
TRIM72 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM72 35
  • 90.99 (n)
  • 93.5 (a)
TRIM72 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim72 35
  • 85.81 (n)
  • 91.19 (a)
Trim72 16
Trim72 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM72 35
  • 99.65 (n)
  • 100 (a)
TRIM72 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim72 35
  • 84.77 (n)
  • 90.78 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM72 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM72 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM72 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim72 35
  • 63.35 (n)
  • 59.4 (a)
Species with no ortholog for TRIM72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM72 Gene

ENSEMBL:
Gene Tree for TRIM72 (if available)
TreeFam:
Gene Tree for TRIM72 (if available)

Paralogs for TRIM72 Gene

Paralogs for TRIM72 Gene

(4) SIMAP similar genes for TRIM72 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM72: view

Variants for TRIM72 Gene

Sequence variations from dbSNP and Humsavar for TRIM72 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs8062530 -- 31,213,067(+) tttca(C/T)tgtgg upstream-variant-2KB
rs4496161 -- 31,212,555(+) ctccc(A/G)ggttc upstream-variant-2KB
rs4516243 -- 31,223,072(+) CTTTG(C/G/T)CTCTG intron-variant
rs61511265 -- 31,223,521(+) ACTGG(G/T)TCTAG intron-variant
rs9927298 -- 31,221,116(+) GTGCC(A/G)TGAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM72 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
dgv2672n71 CNV Loss 21882294
nsv905744 CNV Loss 21882294
nsv905745 CNV Loss 21882294
nsv905746 CNV Loss 21882294

Variation tolerance for TRIM72 Gene

Gene Damage Index Score: 2.11; 38.51% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM72 Gene

Disorders for TRIM72 Gene

Relevant External Links for TRIM72

Genetic Association Database (GAD)
TRIM72
Human Genome Epidemiology (HuGE) Navigator
TRIM72
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM72

No disorders were found for TRIM72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM72 Gene

Publications for TRIM72 Gene

  1. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. (PMID: 23354051) Song R. … Xiao R.P. (Nature 2013) 2 3 67
  2. TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. (PMID: 20399744) Jung S.Y. … Ko Y.G. (Biochem. Biophys. Res. Commun. 2010) 2 3
  3. Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes. (PMID: 25869134) Cai C. … Ma J. (J. Biol. Chem. 2015) 3
  4. Modulation of wound healing and scar formation by MG53 protein-mediated cell membrane repair. (PMID: 26306047) Li H. … Ma J. (J. Biol. Chem. 2015) 3
  5. Mitsugumin 53 (MG53) ligase ubiquitinates focal adhesion kinase during skeletal myogenesis. (PMID: 24344130) Nguyen N. … Ko Y.G. (J. Biol. Chem. 2014) 3

Products for TRIM72 Gene

Sources for TRIM72 Gene

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