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TRIM72 Gene

protein-coding   GIFtS: 48
GCID: GC16P031220

Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase

(Previous names: tripartite motif-containing 72, tripartite motif containing...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase1 2     mitsugumin-532
MG532 3 5     Tripartite Motif-Containing Protein 722
Tripartite Motif-Containing 721 2     Mg533
Mitsugumin 531 2     Mitsugumin-533
Tripartite Motif Containing 721     

External Ids:    HGNC: 326711   Entrez Gene: 4938292   Ensembl: ENSG000001772387   OMIM: 6132885   UniProtKB: Q6ZMU53   

Export aliases for TRIM72 gene to outside databases

Previous GC identifers: GC16P031119 GC16P031025 GC16P031084 GC16P028786


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIM72 Gene:
TRIM72 (tripartite motif containing 72, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with TRIM72 include systemic lupus erythematosus, and muscular dystrophy. GO annotations related to this gene include phosphatidylserine binding. An important paralog of this gene is TRIM31.

UniProtKB/Swiss-Prot: TRI72_HUMAN, Q6ZMU5
Function: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of
the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon
membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and
homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of
TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the
Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair
patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of
KCNB1-containing endocytic vesicles (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_187260.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM72 gene promoter:
         E2F-4   E2F-3a   E2F-5   p53   MIF-1   E2F-2   E2F   E2F-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM72 promoter sequence
   Search Chromatin IP Primers for TRIM72

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM72


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p11.2   Ensembl cytogenetic band:  16p11.2   HGNC cytogenetic band: 16p11.2

TRIM72 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM72 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P031220:  view genomic region     (about GC identifiers)

Start:
31,225,342 bp from pter      End:
31,236,510 bp from pter
Size:
11,169 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI72_HUMAN, Q6ZMU5 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 72  
Size: 477 amino acids; 52731 Da
Subunit: Homooligomer; disulfide-linked. Interacts with DYSF and CAV3 (By similarity)
Sequence caution: Sequence=BAC03506.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TRIM72:
3KB5 (3D)    
Secondary accessions: Q8N4X6 Q8NBD9
Alternative splicing: 2 isoforms:  Q6ZMU5-1   Q6ZMU5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM72: NX_Q6ZMU5

Explore proteomics data for TRIM72 at MOPED

Post-translational modifications: 

  • Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu
    of the extracellular space, resulting in homooligomerization (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM72 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001008275.2  
    ENSEMBL proteins: 
     ENSP00000312675  

    TRIM72 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q6ZMU5

    ProtoNet protein and cluster: Q6ZMU5

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI72_HUMAN, Q6ZMU5
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM72 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI72_HUMAN, Q6ZMU5
    Function: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of
    the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon
    membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and
    homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of
    TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the
    Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair
    patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of
    KCNB1-containing endocytic vesicles (By similarity)

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001786phosphatidylserine binding ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM72 for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trim72):
     behavior/neurological  muscle 

    TRIM72 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TRIM72: Trim72tm1Ygko Trim72tm1Hta

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM72
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM72
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM72

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI72_HUMAN, Q6ZMU5: Cell membrane, sarcolemma (By similarity). Cytoplasmic vesicle membrane (By similarity).
    Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine (By
    similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0030659cytoplasmic vesicle membrane ISS--
    GO:0042383sarcolemma ISS--

    TRIM72 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM72: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM72

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TRIM72 (Q6ZMU53 ENSP000003126754) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2IP632793, ENSP000003248974I2D: score=2 STRING: ENSP00000324897
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001778plasma membrane repair ISS--
    GO:0003012muscle system process ISS--
    GO:0006887exocytosis IEA--
    GO:0007517muscle organ development ISS--
    GO:0051260protein homooligomerization ISS--

    TRIM72 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM72 (TRI72)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM72 gene: 
    NM_001008274.3  

    Unigene Cluster for TRIM72:

    Tripartite motif containing 72
    Hs.661859  [show with all ESTs]
    Unigene Representative Sequence: NM_001008274
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000322122(uc002ebn.2)
    miRNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM72
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM72
      QuantiFast Probe-based Assays in human, mouse, rat TRIM72

    Additional mRNA sequence: 

    AK090695.1 AK131485.1 BC033211.1 

    3 DOTS entries:

    DT.91700681  DT.102821284  DT.100011125 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM72 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGTAAACC
    TRIM72 Expression
    About this image

    TRIM72 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM72 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.661859
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM72: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM72 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim721 , 5 tripartite motif-containing 721, 5 85.81(n)1
    91.19(a)1
      7 (69.89 cM)5
    4342461  NM_001079932.31  NP_001073401.11 
     1280039895 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM726
    tripartite motif containing 72
    63(a)
    1 ↔ 1
    GL343220.1(2369790-2385135)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trim721 tripartite motif containing 72 63.35(n)
    59.4(a)
      493550  NM_001008187.1  NP_001008188.1 


    ENSEMBL Gene Tree for TRIM72 (if available)
    TreeFam Gene Tree for TRIM72 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM72 gene
    TRIM312  TRIM502  TRIM102  TRIM732  TRIM692  TRIM152  TRIM262  TRIM742  
    TRIM352  TRIM522  TRIM622  TRIM412  
    4 SIMAP similar genes for TRIM72 using alignment to 1 protein entry:     TRI72_HUMAN:
    TRIM50    BTNL9    TRIM39    TRIM62

    TRIM72 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM72 (see all 202)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs735322491,2
    C,F--28798549(+) GTCACT/CCAAGG 1 -- ds50013Minor allele frequency- C:0.10WA 122
    rs1145172001,2
    C,F--31223357(+) AAATCA/GGGGAA 1 -- us2k11Minor allele frequency- G:0.04WA 118
    rs1842845951,2
    --31223363(+) GGGAAC/TTGGGA 1 -- us2k10--------
    rs1889992021,2
    --31223429(+) GCCATA/GCAGTA 1 -- us2k10--------
    rs1415731161,2
    C--31223536(+) TGATTA/GATGGG 1 -- us2k10--------
    rs118657301,2
    C,F,H--31223549(+) CATAGC/TAGATA 1 -- us2k1 tfbs311Minor allele frequency- T:0.01NS EA NA 1374
    rs1864230941,2
    --31223578(+) TTAGCA/GCTTTG 1 -- us2k10--------
    rs2004100751,2
    --31223634(+) TATTG-/TTTTTT 1 -- us2k10--------
    rs1920924451,2
    --31223720(+) TCCCAA/GGTTCA 1 -- us2k10--------
    rs1502960211,2
    C--31223750(+) CCTCCC/TGAGCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM72 (31225342 - 31236510 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRIM72:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv905729CNV Loss21882294
    nsv905745CNV Loss21882294
    dgv2670n71CNV Loss21882294
    nsv905746CNV Loss21882294
    nsv905744CNV Loss21882294
    dgv2672n71CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM72
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM72

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613288    OMIM disorders: --

    3 diseases for TRIM72:    About MalaCards
    systemic lupus erythematosus    muscular dystrophy    lupus erythematosus

    1 disease from the University of Copenhagen DISEASES database for TRIM72:
    Muscular dystrophy

    TRIM72 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM72
    Human Genome Epidemiology (HuGE) Navigator: TRIM72 (1 document)

    Export disorders for TRIM72 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM72 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TRIM72)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders. (PubMed id 23354051)1, 3 Song R....Xiao R.P. (Nature 2013)
    2. TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. (PubMed id 20399744)1, 3 Jung S.Y. and Ko Y.G. (Biochem. Biophys. Res. Commun. 2010)
    3. Crystal structure of PRY-SPRY domain of human TRIM72. (PubMed id 19967786)1, 2 Park E.Y....Song H.K. (Proteins 2010)
    4. Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). (PubMed id 19129174)1, 4 Han S....Nath S.K. (Hum. Mol. Genet. 2009)
    5. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (Nature 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling. (PubMed id 23965929)1 Yi J.S....Ko Y.G. (Nat Commun 2013)
    9. TRIM proteins in therapeutic membrane repair of muscular dystrophy. (PubMed id 23699904)1 Alloush J. and Weisleder N. (JAMA Neurol 2013)
    10. Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair. (PubMed id 22253476)1 Lin P....Ma J. (FASEB J. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 493829 HGNC: 32671 Ensembl:ENSG00000177238 euGenes: HUgn493829 ECgene: TRIM72
    H-InvDB: TRIM72

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM72 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM72 gene:
    Search GeneIP for patents involving TRIM72

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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