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Aliases for TRIM72 Gene

Aliases for TRIM72 Gene

  • Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase 2 3
  • MG53 3 4 6
  • Tripartite Motif-Containing 72 2 3
  • Mitsugumin 53 2 3
  • Mitsugumin-53 3 4
  • Tripartite Motif-Containing Protein 72 3
  • Tripartite Motif Containing 72 2

External Ids for TRIM72 Gene

Previous GeneCards Identifiers for TRIM72 Gene

  • GC16P031119
  • GC16P031025
  • GC16P031084
  • GC16P028786

Summaries for TRIM72 Gene

GeneCards Summary for TRIM72 Gene

TRIM72 (Tripartite Motif Containing 72, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. GO annotations related to this gene include phosphatidylserine binding. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM72 Gene

  • Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM72 Gene

Genomics for TRIM72 Gene

Regulatory Elements for TRIM72 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM72 Gene

Start:
31,214,021 bp from pter
End:
31,226,427 bp from pter
Size:
12,407 bases
Orientation:
Plus strand

Genomic View for TRIM72 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM72 Gene

Proteins for TRIM72 Gene

  • Protein details for TRIM72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMU5-TRI72_HUMAN
    Recommended name:
    Tripartite motif-containing protein 72
    Protein Accession:
    Q6ZMU5
    Secondary Accessions:
    • Q8N4X6
    • Q8NBD9

    Protein attributes for TRIM72 Gene

    Size:
    477 amino acids
    Molecular mass:
    52731 Da
    Quaternary structure:
    • Homooligomer; disulfide-linked. Interacts with DYSF and CAV3 (By similarity).
    SequenceCaution:
    • Sequence=BAC03506.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM72 Gene

    Alternative splice isoforms for TRIM72 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM72 Gene

Proteomics data for TRIM72 Gene at MOPED

Post-translational modifications for TRIM72 Gene

  • Disulfide bond formation at Cys-242 occurs in case of membrane damage that cause the entry of the oxidized milieu of the extracellular space, resulting in homooligomerization.
  • S-nitrosylation at Cys-144 stabilizes TRIM72 and protects against oxidation-induced protein degradation and cell death.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM72 Gene

Domains for TRIM72 Gene

Gene Families for TRIM72 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM72 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMU5

UniProtKB/Swiss-Prot:

TRI72_HUMAN :
  • Q6ZMU5
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM72: view

Function for TRIM72 Gene

Molecular function for TRIM72 Gene

UniProtKB/Swiss-Prot Function: Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles (By similarity).

Gene Ontology (GO) - Molecular Function for TRIM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001786 phosphatidylserine binding ISS --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM72: view

Phenotypes for TRIM72 Gene

genes like me logo Genes that share phenotypes with TRIM72: view

Animal Models for TRIM72 Gene

MGI Knock Outs for TRIM72:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM72

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM72 Gene

Localization for TRIM72 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM72 Gene

Cell membrane, sarcolemma. Cytoplasmic vesicle membrane. Note=Tethered to plasma membrane and cytoplasmic vesicles via its interaction with phosphatidylserine. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM72 Gene COMPARTMENTS Subcellular localization image for TRIM72 gene
Compartment Confidence
plasma membrane 4
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0030659 cytoplasmic vesicle membrane TAS --
GO:0042383 sarcolemma ISS --
genes like me logo Genes that share ontologies with TRIM72: view

Pathways for TRIM72 Gene

SuperPathways for TRIM72 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001778 plasma membrane repair ISS --
GO:0003012 muscle system process ISS --
GO:0006887 exocytosis IEA --
GO:0007517 muscle organ development ISS --
GO:0051260 protein homooligomerization ISS --
genes like me logo Genes that share ontologies with TRIM72: view

No data available for Pathways by source for TRIM72 Gene

Transcripts for TRIM72 Gene

mRNA/cDNA for TRIM72 Gene

(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM72 Gene

Tripartite motif containing 72:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM72

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM72 Gene

No ASD Table

Relevant External Links for TRIM72 Gene

GeneLoc Exon Structure for
TRIM72
ECgene alternative splicing isoforms for
TRIM72

Expression for TRIM72 Gene

mRNA expression in normal human tissues for TRIM72 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM72 Gene

This gene is overexpressed in Muscle - Skeletal (44.9).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM72 Gene

SOURCE GeneReport for Unigene cluster for TRIM72 Gene Hs.661859

genes like me logo Genes that share expressions with TRIM72: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM72 Gene

Orthologs for TRIM72 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM72 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM72 35
  • 99.65 (n)
  • 100 (a)
TRIM72 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM72 35
  • 91.68 (n)
  • 94.71 (a)
TRIM72 36
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM72 35
  • 90.99 (n)
  • 93.5 (a)
TRIM72 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim72 35
  • 85.81 (n)
  • 91.19 (a)
Trim72 16
Trim72 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM72 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM72 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim72 35
  • 84.77 (n)
  • 90.78 (a)
lizard
(Anolis carolinensis)
Reptilia TRIM72 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim72 35
  • 63.35 (n)
  • 59.4 (a)
Species with no ortholog for TRIM72:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM72 Gene

ENSEMBL:
Gene Tree for TRIM72 (if available)
TreeFam:
Gene Tree for TRIM72 (if available)

Paralogs for TRIM72 Gene

Selected SIMAP similar genes for TRIM72 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM72: view

Variants for TRIM72 Gene

Sequence variations from dbSNP and Humsavar for TRIM72 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3060409 -- 31,222,482(-) aaaaa(-/AAAA)gaaga intron-variant
rs4496161 -- 31,212,555(+) ctccc(A/G)ggttc upstream-variant-2KB
rs4516243 -- 31,223,072(+) CTTTG(C/G/T)CTCTG intron-variant
rs4889540 -- 31,214,084(+) CTGGG(A/G)CCATG utr-variant-5-prime
rs5816524 -- 31,222,483(+) CTTCT(-/TTTT/TTTTT)TTTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM72 Gene

Variant ID Type Subtype PubMed ID
nsv905729 CNV Loss 21882294
dgv2670n71 CNV Loss 21882294
dgv2672n71 CNV Loss 21882294
nsv905744 CNV Loss 21882294
nsv905745 CNV Loss 21882294
nsv905746 CNV Loss 21882294

Relevant External Links for TRIM72 Gene

HapMap Linkage Disequilibrium report
TRIM72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM72 Gene

Disorders for TRIM72 Gene

(1) University of Copenhagen DISEASES for TRIM72 Gene

Relevant External Links for TRIM72

Genetic Association Database (GAD)
TRIM72
Human Genome Epidemiology (HuGE) Navigator
TRIM72
genes like me logo Genes that share disorders with TRIM72: view

No data available for UniProtKB/Swiss-Prot for TRIM72 Gene

Publications for TRIM72 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J. … Pennacchio L.A. (Nature 2004) 3 4
  4. Crystal structure of PRY-SPRY domain of human TRIM72. (PMID: 19967786) Park E.Y. … Song H.K. (Proteins 2010) 3 4
  5. TRIM72, a novel negative feedback regulator of myogenesis, is transcriptionally activated by the synergism of MyoD (or myogenin) and MEF2. (PMID: 20399744) Jung S.Y. … Ko Y.G. (Biochem. Biophys. Res. Commun. 2010) 2 3

Products for TRIM72 Gene

Sources for TRIM72 Gene

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