Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM71 Gene

Aliases for TRIM71 Gene

  • Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase 2 3
  • Tripartite Motif-Containing Protein 71 3 4
  • Tripartite Motif-Containing 71 2 3
  • Protein Lin-41 Homolog 3 4
  • LIN41 3 4
  • E3 Ubiquitin-Protein Ligase TRIM71 3
  • Tripartite Motif Containing 71 2
  • Abnormal Cell LINeage LIN-41 3
  • Homolog Of C. Elegans Lin-41 3
  • EC 6.3.2.- 4
  • LIN-41 3

External Ids for TRIM71 Gene

Summaries for TRIM71 Gene

GeneCards Summary for TRIM71 Gene

TRIM71 (Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer. GO annotations related to this gene include ubiquitin-protein transferase activity and miRNA binding. An important paralog of this gene is TRIM45.

UniProtKB/Swiss-Prot for TRIM71 Gene

  • E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM71 Gene

Genomics for TRIM71 Gene

Genomic Location for TRIM71 Gene

Start:
32,818,018 bp from pter
End:
32,897,826 bp from pter
Size:
79,809 bases
Orientation:
Plus strand

Genomic View for TRIM71 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM71 Gene

Regulatory Elements for TRIM71 Gene

Proteins for TRIM71 Gene

  • Protein details for TRIM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2Q1W2-LIN41_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM71
    Protein Accession:
    Q2Q1W2
    Secondary Accessions:

    Protein attributes for TRIM71 Gene

    Size:
    868 amino acids
    Molecular mass:
    93385 Da
    Quaternary structure:
    • Interacts (via NHL repeats) with AGO2. Interacts with SHCBP1; leading to enhance its stability (By similarity).

neXtProt entry for TRIM71 Gene

Proteomics data for TRIM71 Gene at MOPED

Post-translational modifications for TRIM71 Gene

Other Protein References for TRIM71 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM71 Gene

Domains for TRIM71 Gene

Gene Families for TRIM71 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

LIN41_HUMAN
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q2Q1W2
Similarity:
  • Contains 2 B box-type zinc fingers.:
    • Q2Q1W2
  • Contains 1 filamin repeat.:
    • Q2Q1W2
  • Contains 6 NHL repeats.:
    • Q2Q1W2
  • Contains 1 RING-type zinc finger.:
    • Q2Q1W2
genes like me logo Genes that share domains with TRIM71: view

Function for TRIM71 Gene

Molecular function for TRIM71 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).
UniProtKB/Swiss-Prot Induction: Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3-UTR of the mRNA encoding this protein. Down-regulated by retinoic acid in Tera-2 cells.

Enzyme Numbers (IUBMB) for TRIM71 Gene

Gene Ontology (GO) - Molecular Function for TRIM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity ISS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0030371 translation repressor activity IDA 23125361
genes like me logo Genes that share ontologies with TRIM71: view
genes like me logo Genes that share phenotypes with TRIM71: view

miRNA for TRIM71 Gene

miRTarBase miRNAs that target TRIM71

No data available for Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM71 Gene

Localization for TRIM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM71 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM71 Gene COMPARTMENTS Subcellular localization image for TRIM71 gene
Compartment Confidence
cytosol 3
nucleus 3
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 cytoplasmic mRNA processing body ISS --
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with TRIM71: view

Pathways for TRIM71 Gene

SuperPathways for TRIM71 Gene

Superpath Contained pathways
1 MicroRNAs in cancer
genes like me logo Genes that share pathways with TRIM71: view

Pathways by source for TRIM71 Gene

1 KEGG pathway for TRIM71 Gene

UniProtKB/Swiss-Prot Q2Q1W2-LIN41_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle ISS --
GO:0001843 neural tube closure IEA --
GO:0008543 fibroblast growth factor receptor signaling pathway ISS --
GO:0010586 miRNA metabolic process ISS --
GO:0017148 negative regulation of translation IDA 23125361
genes like me logo Genes that share ontologies with TRIM71: view

Transcripts for TRIM71 Gene

mRNA/cDNA for TRIM71 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM71 Gene

Tripartite motif containing 71, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM71 Gene

No ASD Table

Relevant External Links for TRIM71 Gene

GeneLoc Exon Structure for
TRIM71
ECgene alternative splicing isoforms for
TRIM71

Expression for TRIM71 Gene

mRNA expression in normal human tissues for TRIM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM71 Gene

This gene is overexpressed in Testis (18.2).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM71 Gene

SOURCE GeneReport for Unigene cluster for TRIM71 Gene Hs.567678

mRNA Expression by UniProt/SwissProt for TRIM71 Gene

Q2Q1W2-LIN41_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expressions with TRIM71: view

Orthologs for TRIM71 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM71 36
  • 99.7 (n)
  • 100 (a)
TRIM71 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM71 36
  • 88.4 (n)
  • 95.16 (a)
TRIM71 37
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM71 36
  • 89.89 (n)
  • 95.96 (a)
TRIM71 37
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim71 36
  • 84.91 (n)
  • 91.23 (a)
Trim71 16
Trim71 37
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM71 37
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM71 37
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim71 36
  • 85.85 (n)
  • 92.4 (a)
chicken
(Gallus gallus)
Aves TRIM71 36
  • 78.73 (n)
  • 86.03 (a)
TRIM71 37
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM71 37
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486898 36
  • 72.6 (n)
  • 80.49 (a)
Str.10679 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6954 36
zebrafish
(Danio rerio)
Actinopterygii sbcb205 36
trim71 36
  • 66.38 (n)
  • 63.48 (a)
trim71 37
  • 76 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005125 36
  • 48.86 (n)
  • 38.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta wech 36
  • 50.69 (n)
  • 38.49 (a)
wech 37
  • 30 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea lin-41 36
  • 46.31 (n)
  • 41.21 (a)
lin-41 37
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 19 (a)
OneToMany
Species with no ortholog for TRIM71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM71 Gene

ENSEMBL:
Gene Tree for TRIM71 (if available)
TreeFam:
Gene Tree for TRIM71 (if available)

Paralogs for TRIM71 Gene

Paralogs for TRIM71 Gene

Selected SIMAP similar genes for TRIM71 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM71: view

Variants for TRIM71 Gene

Sequence variations from dbSNP and Humsavar for TRIM71 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs876279 -- 32,858,753(+) GACTT(C/T)AAGTG intron-variant
rs939053 -- 32,858,781(-) CTGAA(A/C)AAGTC intron-variant
rs939054 -- 32,862,231(-) TCTCT(G/T)CAAGT intron-variant
rs939057 -- 32,852,889(-) ACTTA(A/G)AATTT intron-variant
rs997519 -- 32,841,917(+) CCGGC(C/T)TCCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM71 Gene

Variant ID Type Subtype PubMed ID
esv6047 CNV Gain 19470904
nsv822051 CNV Gain 20364138

Relevant External Links for TRIM71 Gene

HapMap Linkage Disequilibrium report
TRIM71

Disorders for TRIM71 Gene

(1) University of Copenhagen DISEASES for TRIM71 Gene

Relevant External Links for TRIM71

Genetic Association Database (GAD)
TRIM71
genes like me logo Genes that share disorders with TRIM71: view

No data available for UniProtKB/Swiss-Prot for TRIM71 Gene

Publications for TRIM71 Gene

  1. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down- regulation of putative targets during differentiation. (PMID: 15722555) Lee Y.S. … Dutta A. (J. Biol. Chem. 2005) 3 4
  2. Analysis of the regulation of lin-41 during chick and mouse limb development. (PMID: 16245339) Lancman J.J. … Fallon J.F. (Dev. Dyn. 2005) 3 4
  3. Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. (PMID: 16247770) Maller Schulman B.R. … Slack F.J. (Dev. Dyn. 2005) 3 4
  4. Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. (PMID: 17890240) Lin Y.C. … Li W.H. (Mol. Biol. Evol. 2007) 3 4
  5. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 49

Products for TRIM71 Gene

Sources for TRIM71 Gene

Back to Top

Content