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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM71 Gene

protein-coding   GIFtS: 46
GCID: GC03P032859

tripartite motif containing 71, E3 ubiquitin protein ligase

(Previous names: tripartite motif-containing 71, tripartite motif containing...)
 Explore 2 diseases affiliated with
TRIM71 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TRIM71    

Aliases
for TRIM71 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase1 2     Tripartite Motif Containing 711
LIN411 2 3     Abnormal Cell LINeage LIN-412
LIN-411 2     E3 Ubiquitin-Protein Ligase TRIM712
Tripartite Motif-Containing 711 2     Homolog Of C. Elegans Lin-412
Protein Lin-41 Homolog2 3     EC 6.3.2.-3
Tripartite Motif-Containing Protein 712 3     

External Ids:    HGNC: 326691   Entrez Gene: 1314052   Ensembl: ENSG000002065577   UniProtKB: Q2Q1W23   

Export aliases for TRIM71 gene to outside databases

Previous GC identifers: GC03P032836 GC03P032795


Summaries
for TRIM71 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem
cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating to post-transcriptional
repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell
self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation
of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the
stability of SHCBP1 (By similarity)




Genomic Views
for TRIM71 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM71 gene promoter:
         PPAR-alpha   Tal-1   HSF2   AP-4   ITF-2   Tal-1beta   HNF-4alpha1   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRIM71

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

TRIM71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM71 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P032859:  view genomic region     (about GC identifiers)

Start:
 32,859,510 bp from pter      End:
 32,933,771 bp from pter
Size:
 74,262 bases      Orientation:
 plus strand

Proteins
for TRIM71 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM71  
Size: 868 amino acids; 93385 Da
Subunit: Interacts (via NHL repeats) with AGO2. Interacts with SHCBP1; leading to enhance its stability (By similarity)
Subcellular location: Cytoplasm, P-body (By similarity)

Explore the universe of human proteins at neXtProt for TRIM71: NX_Q2Q1W2

Post-translational modifications:

  • Autoubiquitinated (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q2Q1W2

    • TRIM71 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001034200.1  
    ENSEMBL proteins: 
     ENSP00000373272  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate: TRIM71
    OriGene Custom Protein Services for TRIM71 
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    Novus Biologicals TRIM71 Protein
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TRIM71

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005737cytoplasm ----


    TRIM71 for ontologies           About GeneDecksing



    TRIM71 Antibody Products: 
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    Uscn Antibodies for TRIM71
    ThermoFisher Antibodies for TRIM71

    Assay Products for TRIM71: 
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    Uscn ELISAs and CLIAs for TRIM71

    Protein Domains /
    Families
    for TRIM71 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TRIM71 for domains           About GeneDecksing

    5/11 InterPro domains/families (see all 11):
     IPR017907 Znf_RING_CS
     IPR001298 Filamin
     IPR001841 Znf_RING
     IPR014756 Ig_E-set
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry Q2Q1W2

    ProtoNet protein and cluster: Q2Q1W2

    1 Blocks protein family: IPB000315 B-box zinc finger signature

    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 filamin repeat
    Similarity: Contains 6 NHL repeats
    Similarity: Contains 1 RING-type zinc finger


    Function
    for TRIM71 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem
    cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating to post-transcriptional
    repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell
    self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation
    of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the
    stability of SHCBP1 (By similarity)
    Induction: Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this
    protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein.
    Down-regulated by retinoic acid in Tera-2 cells

    Enzyme Number (IUBMB): EC 6.3.2.-1

    miRNA
    Products:            		miRTarBase miRNAs that target TRIM71:
    hsa-let-7a (MIRT002077)

    OriGene 3'-UTR Clone: TRIM71
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM71
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM71 (see all 37):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-578 hsa-let-7g hsa-miR-1244 hsa-miR-298 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM71 (see all 4)
    OriGene shRNA RFP: TRIM71
    OriGene siRNA: TRIM71
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM71

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TRIM71

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM71 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM71
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRIM71 (NM_001039111)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM71 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TRIM71
    Search LifeMap BioReagents cell lines for TRIM71

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM71

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0008270zinc ion binding IEA--
    GO:0035198miRNA binding ISS--


    TRIM71 for ontologies           About GeneDecksing


    Animal Models:
         8 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Trim71):
     cardiovascular system  craniofacial  embryogenesis  growth/size  integument 
     mortality/aging  nervous system  respiratory system 

    TRIM71 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for TRIM71 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Pathway: Protein modification; protein ubiquitination

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM71

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for TRIM71 (Q2Q1W23 ENSP000003732724) via UniProtKB, MINT, STRING, and/or I2D (see all 11)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNRC6AQ8NDV73, ENSP000003791444I2D: score=1 STRING: ENSP00000379144
    EDC4Q6P2E93, ENSP000003518114I2D: score=1 STRING: ENSP00000351811
    MOV10Q9HCE13, ENSP000003500284I2D: score=1 STRING: ENSP00000350028
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    SF3A3Q128743I2D: score=5 
    About this table

    Gene Ontology (GO): 5/13 biological process terms (GO ID links to tree view) (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle ISS--
    GO:0001843neural tube closure IEA--
    GO:0007275multicellular organismal development ----
    GO:0008543fibroblast growth factor receptor signaling pathway ISS--
    GO:0010586miRNA metabolic process ISS--


    TRIM71 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TRIM71 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM71
    Search CenterWatch for drugs/clinical trials and news about TRIM71 / LIN41 

    Transcripts
    for TRIM71 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TRIM71 gene: 
    NM_001039111.1  

    Unigene Cluster for TRIM71:

    Tripartite motif containing 71, E3 ubiquitin protein ligase
    Hs.567678  [show with all ESTs]
    Unigene Representative Sequence: DQ232881
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000383763(uc003cff.3)

    miRNA
    Products:             		 OriGene 3'-UTR Clone: TRIM71
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TRIM71
    8/37 QIAGEN miScript miRNA Assays for microRNAs that regulate TRIM71 (see all 37):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-578 hsa-let-7g hsa-miR-1244 hsa-miR-298 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM71 (see all 4)
    OriGene shRNA RFP: TRIM71
    OriGene siRNA: TRIM71
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM71
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM71 (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM71
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: TRIM71 (NM_001039111)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM71 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM71
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM71
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM71
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM71

    Additional cDNA sequence: DQ232881.1 

    1 DOTS entry:

    DT.75145569 

    2 AceView cDNA sequences:

    BU844373 BQ277900 

    GeneLoc Exon Structure


    Expression
    for TRIM71 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM71 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: ATATGCACAA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TRIM71 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    OvaryOvigerous CordOvarian Somatic CellsOvary
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM71 Protein Expression from SPIRE MOPED and PaxDB
    SOURCE GeneReport for Unigene cluster: Hs.567678

    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Tissue specificity: Specifically expressed in testis

        SABiosciences Expression via Pathway-Focused PCR Array including TRIM71: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM71

    Orthologs
    for TRIM71 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TRIM71 gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves TRIM711 tripartite motif containing 71 79.52(n)
    86.88(a)    		   428445  NM_001037275.2  NP_001032352.2 
    lizard
    (Anolis carolinensis)    		 Reptilia TRIM716
    		 --
    		 78(a)
    		 1 ↔ 1
    		 1(193362391-193410543)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.106792 Transcribed sequence with weak similarity to protein more 79.35(n)    141995513 
    zebrafish
    (Danio rerio)    		 Actinopterygii sbcb2052 sbcb205 74.73(n)   321153  57044004 
    fruit fly
    (Drosophila melanogaster)    		 Insecta wech1 CG42396-PA 47.51(n)
    34.45(a)    		   44653  NM_001144142.1  NP_001137614.1 
    worm
    (Caenorhabditis elegans)    		 Secernentea lin-411 Protein LIN-41 45.67(n)
    40.38(a)    		   172760  NM_001025828.3  NP_001020999.1 


    ENSEMBL Gene Tree for TRIM71 (if available)
    TreeFam Gene Tree for TRIM71 (if available) 

    Paralogs
    for TRIM71 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM71 gene
    TRIM32  NHLRC12  TRIM452  TRIM562  TRIM22  TRIM322  
    1 SIMAP similar gene for TRIM71 using alignment to 1 protein entry:     LIN41_HUMAN:
    TRIM2

    TRIM71 for paralogs           About GeneDecksing



    Genomic Variants
    for TRIM71 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1365 NCBI SNPs in TRIM71 are shown (see all 1365)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1120313621,2
    		--32793749(+) TCACAC/GTGAAG 1 -- nc-transcript-variant2Minor allele frequency- G:0.08CSA WA 120
    rs730441231,2
    		C,--32793757(+) AAGCCC/TGGGGG 1 -- nc-transcript-variant0--------
    rs8808621,2
    		C--32794407(-) CCCCTC/TCTCCT 1 -- nc-transcript-variant1Minor allele frequency- T:0.00MN 184
    rs756086531,2
    		F,--32794889(+) GGCGAC/TGCACC 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs781167121,2
    		F,--32795161(+) GCACGC/GGGCCC 1 -- us2k11Minor allele frequency- G:0.13EA 120
    rs773459771,2
    		F,--32795163(+) ACGCGG/CCCCCC 1 -- us2k11Minor allele frequency- C:0.06WA 118
    rs752965841,2
    		C,F,--32795370(+) CTCCTC/TCTCCT 1 -- us2k11Minor allele frequency- T:0.12EA 120
    rs800622981,2
    		C,F,--32796548(+) ACGCGG/TCAATC 1 -- us2k11Minor allele frequency- T:0.07WA 118
    rs789433991,2
    		F,--32796567(+) TTAGGC/TGTGAG 1 -- us2k11Minor allele frequency- T:0.03NA 120
    rs112789691,2
    		C--32796611(+) CGTGG-/CCTGCT
                CCTGC     		1 -- us2k11Minor allele frequency- CCTGCT:0.00CSA 2

    HapMap Linkage Disequilibrium report for TRIM71 (32859510 - 32933771 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for TRIM71
         1 Indel: 60413

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM71
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM71

    Disorders / Diseases
    for TRIM71 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TRIM71 for disorders           About GeneDecksing

    2 diseases for TRIM71:    About MalaCards
    otitis media    cholesteatoma

    1 disease from the University of Copenhagen DISEASES database for TRIM71:
    Cholesteatoma

    Export disorders for TRIM71 gene to outside databases

    Publications
    for TRIM71 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM71 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRIM71)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. (PubMed id 17890240)1, 2 Lin Y.C....Li W.H. (2007)
    2. Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. (PubMed id 16247770)1, 2 Maller Schulman B.R.... Slack F.J. (2005)
    3. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down- regulation of putative targets during differentiation. (PubMed id 15722555)1, 2 Lee Y.S.... Dutta A. (2005)
    4. Analysis of the regulation of lin-41 during chick and mouse limb development. (PubMed id 16245339)1, 2 Lancman J.J.... Fallon J.F. (2005)
    5. Trim71 cooperates with microRNAs to repress Cdkn1a exp ression and promote embryonic stem cell proliferation. (PubMed id 22735451)1 Chang H.M....Gregory R.I. (2012)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. Genome-wide association and large-scale follow up iden tifies 16 new loci influencing lung function. (PubMed id 21946350)1 Soler Artigas M....Tobin M.D. (2011)
    9. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    External Searches for TRIM71 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Genome Databases showing TRIM71 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 131405 HGNC: 32669 AceView: LOC131405.2 Ensembl:ENSG00000206557 euGenes: HUgn131405
    ECgene: TRIM71 H-InvDB: TRIM71

    Other Databases showing TRIM71 gene

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    Specialized Databases showing TRIM71 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM71 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
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