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Aliases for TRIM71 Gene

Aliases for TRIM71 Gene

  • Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase 2 3 5
  • Tripartite Motif-Containing Protein 71 3 4
  • Tripartite Motif-Containing 71 2 3
  • Protein Lin-41 Homolog 3 4
  • LIN41 3 4
  • Tripartite Motif Containing 71 2
  • Abnormal Cell LINeage LIN-41 3
  • Homolog Of C. Elegans Lin-41 3
  • EC 6.3.2.- 4
  • LIN-41 3

External Ids for TRIM71 Gene

Previous GeneCards Identifiers for TRIM71 Gene

  • GC03P032836
  • GC03P032795

Summaries for TRIM71 Gene

Entrez Gene Summary for TRIM71 Gene

  • The protein encoded by this gene is an E3 ubiquitin-protein ligase that binds with miRNAs and maintains the growth and upkeep of embryonic stem cells. This gene also is involved in the G1-S phase transition of the cell cycle. [provided by RefSeq, Dec 2015]

GeneCards Summary for TRIM71 Gene

TRIM71 (Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are Immune System and MicroRNAs in cancer. GO annotations related to this gene include ligase activity and miRNA binding. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM71 Gene

  • E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM71 Gene

Genomics for TRIM71 Gene

Regulatory Elements for TRIM71 Gene

Promoters for TRIM71 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM71 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM71 Gene

Chromosome:
3
Start:
32,818,018 bp from pter
End:
32,897,826 bp from pter
Size:
79,809 bases
Orientation:
Plus strand

Genomic View for TRIM71 Gene

Genes around TRIM71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM71 Gene

Proteins for TRIM71 Gene

  • Protein details for TRIM71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2Q1W2-LIN41_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM71
    Protein Accession:
    Q2Q1W2

    Protein attributes for TRIM71 Gene

    Size:
    868 amino acids
    Molecular mass:
    93385 Da
    Quaternary structure:
    • Interacts (via NHL repeats) with AGO2. Interacts with SHCBP1; leading to enhance its stability (By similarity).

neXtProt entry for TRIM71 Gene

Proteomics data for TRIM71 Gene at MOPED

Post-translational modifications for TRIM71 Gene

Other Protein References for TRIM71 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM71 Gene

Domains & Families for TRIM71 Gene

Gene Families for TRIM71 Gene

Suggested Antigen Peptide Sequences for TRIM71 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q2Q1W2

UniProtKB/Swiss-Prot:

LIN41_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 filamin repeat.
  • Contains 6 NHL repeats.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM71: view

Function for TRIM71 Gene

Molecular function for TRIM71 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).
UniProtKB/Swiss-Prot Induction:
Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this protein. This requires a let-7 complementary site (LCS) in the 3-UTR of the mRNA encoding this protein. Down-regulated by retinoic acid in Tera-2 cells.

Enzyme Numbers (IUBMB) for TRIM71 Gene

Gene Ontology (GO) - Molecular Function for TRIM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
GO:0030371 translation repressor activity IDA 23125361
genes like me logo Genes that share ontologies with TRIM71: view
genes like me logo Genes that share phenotypes with TRIM71: view

Animal Model Products

miRNA for TRIM71 Gene

miRTarBase miRNAs that target TRIM71

miRNA Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM71 Gene

Localization for TRIM71 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM71 Gene

Cytoplasm, P-body.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM71 Gene COMPARTMENTS Subcellular localization image for TRIM71 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TRIM71 Gene

Pathways & Interactions for TRIM71 Gene

genes like me logo Genes that share pathways with TRIM71: view

UniProtKB/Swiss-Prot Q2Q1W2-LIN41_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM71 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001843 neural tube closure IEA --
GO:0017148 negative regulation of translation IDA 23125361
GO:0021915 neural tube development IEA,ISS --
GO:0035278 miRNA mediated inhibition of translation IEA,ISS --
GO:0051246 regulation of protein metabolic process IEA --
genes like me logo Genes that share ontologies with TRIM71: view

No data available for SIGNOR curated interactions for TRIM71 Gene

Drugs & Compounds for TRIM71 Gene

No Compound Related Data Available

Transcripts for TRIM71 Gene

mRNA/cDNA for TRIM71 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM71 Gene

Tripartite motif containing 71, E3 ubiquitin protein ligase:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM71 Gene

No ASD Table

Relevant External Links for TRIM71 Gene

GeneLoc Exon Structure for
TRIM71
ECgene alternative splicing isoforms for
TRIM71

Expression for TRIM71 Gene

mRNA expression in normal human tissues for TRIM71 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM71 Gene

This gene is overexpressed in Testis (x18.2).

Protein differential expression in normal tissues from HIPED for TRIM71 Gene

This gene is overexpressed in Fetal ovary (16.7), Pancreatic juice (15.2), Liver (14.4), and Testis (12.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM71 Gene



SOURCE GeneReport for Unigene cluster for TRIM71 Gene Hs.567678

mRNA Expression by UniProt/SwissProt for TRIM71 Gene

Q2Q1W2-LIN41_HUMAN
Tissue specificity: Specifically expressed in testis.
genes like me logo Genes that share expression patterns with TRIM71: view

Protein tissue co-expression partners for TRIM71 Gene

Primer Products

In Situ Assay Products

Orthologs for TRIM71 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM71 36
  • 100 (a)
OneToOne
TRIM71 35
  • 99.7 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia TRIM71 35
  • 88.4 (n)
  • 95.16 (a)
TRIM71 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM71 36
  • 97 (a)
OneToOne
TRIM71 35
  • 89.89 (n)
  • 95.96 (a)
mouse
(Mus musculus)
Mammalia Trim71 16
Trim71 36
  • 93 (a)
OneToOne
Trim71 35
  • 84.91 (n)
  • 91.23 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM71 36
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM71 36
  • 95 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim71 35
  • 85.85 (n)
  • 92.4 (a)
chicken
(Gallus gallus)
Aves TRIM71 35
  • 78.73 (n)
  • 86.03 (a)
TRIM71 36
  • 94 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM71 36
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100486898 35
  • 72.6 (n)
  • 80.49 (a)
Str.10679 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6954 35
zebrafish
(Danio rerio)
Actinopterygii trim71 36
  • 76 (a)
OneToOne
sbcb205 35
trim71 35
  • 66.38 (n)
  • 63.48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005125 35
  • 48.86 (n)
  • 38.92 (a)
fruit fly
(Drosophila melanogaster)
Insecta wech 36
  • 30 (a)
OneToOne
wech 35
  • 50.69 (n)
  • 38.49 (a)
worm
(Caenorhabditis elegans)
Secernentea lin-41 35
  • 46.31 (n)
  • 41.21 (a)
lin-41 36
  • 27 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 19 (a)
OneToMany
Species with no ortholog for TRIM71:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM71 Gene

ENSEMBL:
Gene Tree for TRIM71 (if available)
TreeFam:
Gene Tree for TRIM71 (if available)

Paralogs for TRIM71 Gene

Paralogs for TRIM71 Gene

(1) SIMAP similar genes for TRIM71 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM71: view

Variants for TRIM71 Gene

Sequence variations from dbSNP and Humsavar for TRIM71 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs939053 -- 32,858,781(-) CTGAA(A/C)AAGTC intron-variant
rs939057 -- 32,852,889(+) ACTTA(A/C/G/T)AATTT intron-variant
rs876279 -- 32,858,753(+) GACTT(C/G/T)AAGTG intron-variant
rs1610250 -- 32,882,188(-) AGAAG(A/G)AAAAA intron-variant
rs1599772 -- 32,881,934(-) CAAGC(A/G)TGCAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM71 Gene

Variant ID Type Subtype PubMed ID
esv6047 CNV Gain 19470904
nsv822051 CNV Gain 20364138

Variation tolerance for TRIM71 Gene

Residual Variation Intolerance Score: 10.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.35; 26.68% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM71 Gene

HapMap Linkage Disequilibrium report
TRIM71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM71 Gene

Disorders for TRIM71 Gene

Relevant External Links for TRIM71

Genetic Association Database (GAD)
TRIM71
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM71

No disorders were found for TRIM71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM71 Gene

Publications for TRIM71 Gene

  1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PMID: 21946350) Soler Artigas M. … Tobin M.D. (Nat. Genet. 2011) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  4. The ubiquitin ligase human TRIM71 regulates let-7 microRNA biogenesis via modulation of Lin28B protein. (PMID: 24602972) Lee S.H. … Kim J.H. (Biochim. Biophys. Acta 2014) 3
  5. The mammalian TRIM-NHL protein TRIM71/LIN-41 is a repressor of mRNA function. (PMID: 23125361) Loedige I. … Filipowicz W. (Nucleic Acids Res. 2013) 3

Products for TRIM71 Gene

Sources for TRIM71 Gene

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