Aliases for TRIM71 Gene
External Ids for TRIM71 Gene
GeneCards Summary for TRIM71 Gene
TRIM71 (Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Among its related pathways are MicroRNAs in cancer. GO annotations related to this gene include ubiquitin-protein transferase activity and miRNA binding. An important paralog of this gene is TRIM45.
UniProtKB/Swiss-Prot for TRIM71 Gene
E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent premature differentiation of neural progenitor cells during early neural development: positively regulates FGF signaling by controlling the stability of SHCBP1 (By similarity).