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TRIM71 Gene

protein-coding   GIFtS: 50
GCID: GC03P032859

Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase

(Previous names: tripartite motif-containing 71, tripartite motif containing...)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 71, E3 Ubiquitin Protein Ligase1 2     LIN-412
Tripartite Motif-Containing 711 2     Abnormal Cell LINeage LIN-412
Protein Lin-41 Homolog2 3     E3 Ubiquitin-Protein Ligase TRIM712
Tripartite Motif-Containing Protein 712 3     Homolog Of C. Elegans Lin-412
LIN412 3     EC 6.3.2.-3
Tripartite Motif Containing 711     

External Ids:    HGNC: 326691   Entrez Gene: 1314052   Ensembl: ENSG000002065577   UniProtKB: Q2Q1W23   

Export aliases for TRIM71 gene to outside databases

Previous GC identifers: GC03P032836 GC03P032795


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIM71 Gene:
TRIM71 (tripartite motif containing 71, E3 ubiquitin protein ligase) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity and miRNA binding. An important paralog of this gene is TRIM3.

UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic
stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in
post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid
embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent
premature differentiation of neural progenitor cells during early neural development: positively regulates FGF
signaling by controlling the stability of SHCBP1 (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM71 gene promoter:
         PPAR-alpha   Tal-1   HSF2   AP-4   ITF-2   Tal-1beta   HNF-4alpha1   E47   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRIM71

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM71


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p22.3   Ensembl cytogenetic band:  3p22.3   HGNC cytogenetic band: 3p22.3

TRIM71 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM71 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P032859:  view genomic region     (about GC identifiers)

Start:
32,859,510 bp from pter      End:
32,939,318 bp from pter
Size:
79,809 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM71  
Size: 868 amino acids; 93385 Da
Subunit: Interacts (via NHL repeats) with AGO2. Interacts with SHCBP1; leading to enhance its stability (By
similarity)

Explore the universe of human proteins at neXtProt for TRIM71: NX_Q2Q1W2

Explore proteomics data for TRIM71 at MOPED

Post-translational modifications: 

  • Autoubiquitinated (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM71 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001034200.1  
    ENSEMBL proteins: 
     ENSP00000373272  

    TRIM71 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TRIM71
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    Novus Biologicals TRIM71 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM71

     
    Search eBioscience for Proteins for TRIM71 

     
    antibodies-online proteins for TRIM71 (2 products) 

     
    antibodies-online peptides for TRIM71

    TRIM71 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TRIM71
    Cloud-Clone Corp. Antibodies for TRIM71
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    LSBio Antibodies in human, mouse, rat for TRIM71
    antibodies-online antibodies for TRIM71 (24 products) 

    TRIM71 Assay Products:

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    Cloud-Clone Corp. ELISAs for TRIM71
    Cloud-Clone Corp. CLIAs for TRIM71
    Search eBioscience for ELISAs for TRIM71 
    antibodies-online kits for TRIM71 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 11):
     IPR017907 Znf_RING_CS
     IPR001298 Filamin/ABP280_rpt
     IPR001841 Znf_RING
     IPR014756 Ig_E-set
     IPR011042 6-blade_b-propeller_TolB-like

    Graphical View of Domain Structure for InterPro Entry Q2Q1W2

    ProtoNet protein and cluster: Q2Q1W2

    1 Blocks protein domain: IPB000315 B-box zinc finger signature

    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 filamin repeat
    Similarity: Contains 6 NHL repeats
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM71           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: LIN41_HUMAN, Q2Q1W2
    Function: E3 ubiquitin-protein ligase that cooperates with the microRNAs (miRNAs) machinery and promotes embryonic
    stem cells proliferation and maintenance. Binds to miRNAs and associates with AGO2, participating in
    post-transcriptional repression of transcripts such as CDKN1A. Facilitates the G1-S transition to promote rapid
    embryonic stem cell self-renewal by repressing CDKN1A expression. Required to maintain proliferation and prevent
    premature differentiation of neural progenitor cells during early neural development: positively regulates FGF
    signaling by controlling the stability of SHCBP1 (By similarity)
    Induction: Negatively regulated by the microRNA (miRNA) let-7 which causes degradation of the mRNA encoding this
    protein. This requires a let-7 complementary site (LCS) in the 3'-UTR of the mRNA encoding this protein.
    Down-regulated by retinoic acid in Tera-2 cells

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity ISS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0035198miRNA binding ISS--
         
    Find genes that share ontologies with TRIM71           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trim71):
     cardiovascular system  craniofacial  embryogenesis  growth/size/body  integument 
     mortality/aging  nervous system  respiratory system 

    Find genes that share phenotypes with TRIM71           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM71
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM71

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM71
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM71

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM71:
    hsa-let-7a-5p (MIRT002077), hsa-mir-17-5p (MIRT051040), hsa-let-7c-5p (MIRT002076)

    Block miRNA regulation of human, mouse, rat TRIM71 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM71 (see all 37):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-578 hsa-let-7g hsa-miR-1244 hsa-miR-298 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TRIM71
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM71

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TRIM71 (NM_001039111)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM71
    Addgene plasmids for TRIM71 

    Cell Line
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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM71


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    LIN41_HUMAN, Q2Q1W2: Cytoplasm, P-body (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000932cytoplasmic mRNA processing body ISS--
    GO:0005622intracellular ----

    Find genes that share ontologies with TRIM71           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM71 About    
    See pathways by source

    SuperPathContained pathways About
    1MicroRNAs in cancer
    MicroRNAs in cancer


    Find genes that share SuperPaths with TRIM71           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Kegg Pathway  (Kegg details for TRIM71):
        MicroRNAs in cancer

    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM71: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM71

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for TRIM71 (Q2Q1W23 ENSP000003732724) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TNRC6AQ8NDV73, ENSP000003791444I2D: score=1 STRING: ENSP00000379144
    EDC4Q6P2E93, ENSP000003518114I2D: score=1 STRING: ENSP00000351811
    MOV10Q9HCE13, ENSP000003500284I2D: score=1 STRING: ENSP00000350028
    AGO2Q9UKV83, ENSP000002205924I2D: score=1 STRING: ENSP00000220592
    UBCP0CG483, ENSP000003448184I2D: score=1 STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle ISS--
    GO:0001843neural tube closure IEA--
    GO:0008543fibroblast growth factor receptor signaling pathway ISS--
    GO:0010586miRNA metabolic process ISS--
    GO:0021915neural tube development ISS--

    Find genes that share ontologies with TRIM71           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM71 (LIN41)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM71 gene: 
    NM_001039111.1  

    Unigene Cluster for TRIM71:

    Tripartite motif containing 71, E3 ubiquitin protein ligase
    Hs.567678  [show with all ESTs]
    Unigene Representative Sequence: DQ232881
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000383763(uc003cff.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM71 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM71 (see all 37):
    hsa-miR-3607-3p hsa-let-7d hsa-miR-513a-5p hsa-miR-578 hsa-let-7g hsa-miR-1244 hsa-miR-298 hsa-let-7a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM71
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM71
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM71 (NM_001039111)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM71
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM71
    Addgene plasmids for TRIM71 
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM71
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM71
      QuantiFast Probe-based Assays in human, mouse, rat TRIM71

    Additional mRNA sequence: DQ232881.1 

    1 DOTS entry:

    DT.75145569 

    2 AceView cDNA sequences:

    BU844373 BQ277900 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM71 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATATGCACAA
    TRIM71 Expression
    About this image


    TRIM71 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Ovary (Reproductive System)
             Ovarian Somatic Cells Ovigerous Cord
     
     Blood (Cardiovascular System)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
     
     Yolk Sac (Extraembryonic Tissues)
             Definitive Hematopoietic Stem Cells Definitive Yolk Sac
    TRIM71 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM71 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.567678

    UniProtKB/Swiss-Prot: LIN41_HUMAN, Q2Q1W2
    Tissue specificity: Specifically expressed in testis

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM71: 
              Ubiquitin Ligases in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM71

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM71 gene from Selected species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim711 , 5 tripartite motif-containing 711, 5 84.91(n)1
    91.23(a)1
      9 (64.54 cM)5
    6369311  NM_001042503.21  NP_001035968.11 
     1145071335 
    chicken
    (Gallus gallus)
    Aves TRIM711 tripartite motif containing 71, E3 ubiquitin protein more 78.73(n)
    86.03(a)
      428445  NM_001037275.2  NP_001032352.2 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM716
    tripartite motif containing 71, E3 ubiquitin prote...
    79(a)
    1 ↔ 1
    1(193362391-193410552)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.106792 Transcribed sequence with weak similarity to protein more 79.35(n)    141995513 
    zebrafish
    (Danio rerio)
    Actinopterygii sbcb2052 sbcb205 74.73(n)   321153  57044004 
    fruit fly
    (Drosophila melanogaster)
    Insecta wech1 wech 50.69(n)
    38.49(a)
      44653  NM_001144142.2  NP_001137614.1 
    worm
    (Caenorhabditis elegans)
    Secernentea lin-411 lin-41 46.31(n)
    41.21(a)
      172760  NM_001025827.4  NP_001020998.1 


    ENSEMBL Gene Tree for TRIM71 (if available)
    TreeFam Gene Tree for TRIM71 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM71 gene
    TRIM32  TRIM562  TRIM452  TRIM22  
    1 SIMAP similar gene for TRIM71 using alignment to 1 protein entry:     LIN41_HUMAN:
    TRIM2

    Find genes that share paralogs with TRIM71           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM71 (see all 1678)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1817316511,2
    --32860928(+) GCCTCC/TGTAGA 1 -- int10--------
    rs562365311,2
    C,F--32860971(+) GACTGG/TTTTTT 1 -- int12Minor allele frequency- T:0.06WA 120
    rs1121153241,2
    C--32860972(+) ACTGGT/-TTTTT 1 -- int11Minor allele frequency- -:0.50CSA 2
    rs1851652661,2
    C--32861014(+) CCTTAC/TGTTGG 1 -- int10--------
    rs1907551891,2
    --32861033(+) GGGAGC/TGTCTG 1 -- int10--------
    rs1140440031,2
    F--32861102(+) CCTATA/GTTGTT 1 -- int11Minor allele frequency- G:0.03WA 118
    rs1118329981,2
    C,F--32861126(+) CTGGCG/CCCTGA 1 -- int11Minor allele frequency- C:0.50NA 2
    rs785325861,2
    C,F--32861196(+) GAATAA/GAGGGA 1 -- int11Minor allele frequency- G:0.04EA 120
    rs1820458281,2
    C--32861242(+) GCGCCC/GGCCTG 1 -- int10--------
    rs1872551341,2
    --32861481(+) CTTTGA/GTATTA 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM71 (32859510 - 32939318 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TRIM71:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822051CNV Gain20364138
    esv6047CNV Gain19470904

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease from the University of Copenhagen DISEASES database for TRIM71:
    Cholesteatoma

    Find genes that share disorders with TRIM71           About GenesLikeMe

    Genetic Association Database (GAD): TRIM71

    Export disorders for TRIM71 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM71 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with TRIM71)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. (PubMed id 21946350)1, 4 Soler Artigas M....Tobin M.D. (Nat. Genet. 2011)
    2. Human TRIM71 and its nematode homologue are targets of let-7 microRNA and its zebrafish orthologue is essential for development. (PubMed id 17890240)1, 2 Lin Y.C.... Li W.H. (Mol. Biol. Evol. 2007)
    3. Reciprocal expression of lin-41 and the microRNAs let-7 and mir-125 during mouse embryogenesis. (PubMed id 16247770)1, 2 Maller Schulman B.R.... Slack F.J. (Dev. Dyn. 2005)
    4. Depletion of human micro-RNA miR-125b reveals that it is critical for the proliferation of differentiated cells but not for the down- regulation of putative targets during differentiation. (PubMed id 15722555)1, 2 Lee Y.S.... Dutta A. (J. Biol. Chem. 2005)
    5. Analysis of the regulation of lin-41 during chick and mouse limb development. (PubMed id 16245339)1, 2 Lancman J.J.... Fallon J.F. (Dev. Dyn. 2005)
    6. The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing. (PubMed id 23097274)1 Chen Y.L....Jeng Y.M. (J. Pathol. 2013)
    7. Exploration of deleterious single nucleotide polymorphisms in the components of human P bodies: an in silico approach. (PubMed id 23892092)1 Venkatesh T. and Suresh P.S. (Gene 2013)
    8. Trim71 cooperates with microRNAs to repress Cdkn1a expression and promote embryonic stem cell proliferation. (PubMed id 22735451)1 Chang H.M....Gregory R.I. (Nat Commun 2012)
    9. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    10. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 131405 HGNC: 32669 AceView: LOC131405.2 Ensembl:ENSG00000206557 euGenes: HUgn131405
    ECgene: TRIM71 Kegg: 131405 H-InvDB: TRIM71

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM71 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM71 gene:
    Search GeneIP for patents involving TRIM71

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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