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Aliases for TRIM7 Gene

Aliases for TRIM7 Gene

  • Tripartite Motif Containing 7 2 3 5
  • Glycogenin-Interacting Protein 2 3 4
  • Tripartite Motif-Containing Protein 7 3 4
  • Tripartite Motif Protein TRIM7 2 3
  • RING Finger Protein 90 3 4
  • RNF90 3 4
  • GNIP 3 4
  • E3 Ubiquitin-Protein Ligase TRIM7 3
  • Tripartite Motif-Containing 7 2
  • EC 2.3.2.27 4

External Ids for TRIM7 Gene

Previous GeneCards Identifiers for TRIM7 Gene

  • GC05M180671
  • GC05P181733
  • GC05M180683
  • GC05M180739
  • GC05M180732
  • GC05M180553
  • GC05M180620
  • GC05M175348

Summaries for TRIM7 Gene

Entrez Gene Summary for TRIM7 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TRIM7 Gene

TRIM7 (Tripartite Motif Containing 7) is a Protein Coding gene. An important paralog of this gene is TRIM27.

UniProtKB/Swiss-Prot for TRIM7 Gene

  • E3 ubiquitin-protein ligase. Mediates Lys-63-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation.

Additional gene information for TRIM7 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM7 Gene

Genomics for TRIM7 Gene

GeneHancer (GH) Regulatory Elements for TRIM7 Gene

Promoters and enhancers for TRIM7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I181202 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 579.6 -0.4 -417 5.6 CLOCK ZFP64 IRF4 YY1 ZNF213 E2F8 SP3 NFYC ZNF610 GLIS1 TRIM7 ENSG00000248514 GC05P181245 PIR42038 TRA-TGC3-1 TRIM52 ENSG00000233937 ZFP62 CNOT6 RACK1
GH05I181187 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 20.3 +15.1 15063 6.5 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 SSRP1 GLIS1 RCOR2 GC05M181233 GC05M181234 LINC01962 LOC105377769 PIR54518 TRP-TGG3-1 TRT-TGT6-1 TRV-AAC2-1 TRIM52 ENSG00000233937
GH05I181183 Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 15.2 +21.0 21028 2.1 HDGF CLOCK SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 POLR2B ENSG00000233937 RACK1 ENSG00000248514 CNOT6 ZFP62 TRIM7 TRIM52 SNORD96A MGAT1 TRL-AAG2-1
GH05I180798 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 10.6 +399.7 399723 14.1 ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 SP3 MGAT1 ENSG00000233937 RACK1 GFPT2 RN7SKP150 LOC100996419 ENSG00000250900 TRIM7 ZFP62 ENSG00000280161
GH05I181215 Enhancer 1.5 Ensembl ENCODE dbSUPER 14.3 -12.2 -12242 3.3 CLOCK MLX FEZF1 IRF4 YY1 ZNF213 E2F8 ZNF143 ZNF548 SP3 TRV-AAC1-4 ENSG00000233937 RACK1 TRIM52 TRIM52-AS1 ZFP62 CNOT6 SNORD96A MGAT1 TRIM7
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM7 gene promoter:

Genomic Locations for TRIM7 Gene

Genomic Locations for TRIM7 Gene
chr5:181,193,924-181,205,293
(GRCh38/hg38)
Size:
11,370 bases
Orientation:
Minus strand
chr5:180,620,924-180,632,293
(GRCh37/hg19)

Genomic View for TRIM7 Gene

Genes around TRIM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM7 Gene

Proteins for TRIM7 Gene

  • Protein details for TRIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C029-TRIM7_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM7
    Protein Accession:
    Q9C029
    Secondary Accessions:
    • A2RUE4
    • D3DWR7
    • Q969F5
    • Q96F67
    • Q96J89
    • Q96J90

    Protein attributes for TRIM7 Gene

    Size:
    511 amino acids
    Molecular mass:
    56631 Da
    Quaternary structure:
    • Forms homodimers, and heterodimers with GNIP2 (PubMed:14984203, PubMed:25851810). Interacts with GYG (PubMed:11916970, PubMed:14984203). Interacts with RNF187 (via C-terminus) (PubMed:25851810).

    Alternative splice isoforms for TRIM7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM7 Gene

Post-translational modifications for TRIM7 Gene

  • Phosphorylated at Ser-107 by RPS6KA5/MSK1, which stimulates the ubiquitin ligase activity.

No data available for DME Specific Peptides for TRIM7 Gene

Domains & Families for TRIM7 Gene

Gene Families for TRIM7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for TRIM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9C029

UniProtKB/Swiss-Prot:

TRIM7_HUMAN :
  • The B30.2 domain mediates interaction with GYG.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The B30.2 domain mediates interaction with GYG.
  • The coiled-coil region mediates homodimerization and heterodimerization.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM7: view

Function for TRIM7 Gene

Molecular function for TRIM7 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase. Mediates Lys-63-linked polyubiquitination and stabilization of the JUN coactivator RNF187 in response to growth factor signaling via the MEK/ERK pathway, thereby regulating JUN transactivation and cellular proliferation.

Enzyme Numbers (IUBMB) for TRIM7 Gene

Phenotypes From GWAS Catalog for TRIM7 Gene

Gene Ontology (GO) - Molecular Function for TRIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM7: view
genes like me logo Genes that share phenotypes with TRIM7: view

miRNA for TRIM7 Gene

miRTarBase miRNAs that target TRIM7

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM7 Gene

Localization for TRIM7 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM7 gene
Compartment Confidence
nucleus 5
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IDA 11331580
GO:0005737 cytoplasm IDA 11331580
genes like me logo Genes that share ontologies with TRIM7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM7 Gene

Pathways & Interactions for TRIM7 Gene

SuperPathways for TRIM7 Gene

No Data Available

UniProtKB/Swiss-Prot Q9C029-TRIM7_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM7: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM7 Gene

Drugs & Compounds for TRIM7 Gene

No Compound Related Data Available

Transcripts for TRIM7 Gene

Unigene Clusters for TRIM7 Gene

Tripartite motif containing 7:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -
SP6:

Relevant External Links for TRIM7 Gene

GeneLoc Exon Structure for
TRIM7
ECgene alternative splicing isoforms for
TRIM7

Expression for TRIM7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM7 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8), Brain - Cerebellum (x5.6), Brain - Cerebellar Hemisphere (x4.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM7 Gene

This gene is overexpressed in Cerebrospinal fluid (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM7 Gene



Protein tissue co-expression partners for TRIM7 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM7 Gene:

TRIM7

SOURCE GeneReport for Unigene cluster for TRIM7 Gene:

Hs.487412

mRNA Expression by UniProt/SwissProt for TRIM7 Gene:

Q9C029-TRIM7_HUMAN
Tissue specificity: Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.

Evidence on tissue expression from TISSUES for TRIM7 Gene

  • Lung(4.3)
  • Muscle(4.3)
genes like me logo Genes that share expression patterns with TRIM7: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM7 Gene

Orthologs for TRIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM7 34
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM7 33 34
  • 87.88 (n)
dog
(Canis familiaris)
Mammalia TRIM7 33 34
  • 86.85 (n)
mouse
(Mus musculus)
Mammalia Trim7 33 16 34
  • 86.58 (n)
rat
(Rattus norvegicus)
Mammalia Trim7 33
  • 83.86 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM7 34
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM7 34
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM7 33
  • 64.75 (n)
TRIM7.1 34
  • 44 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM7 34
  • 50 (a)
OneToOne
Species where no ortholog for TRIM7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM7 Gene

ENSEMBL:
Gene Tree for TRIM7 (if available)
TreeFam:
Gene Tree for TRIM7 (if available)

Paralogs for TRIM7 Gene

(13) SIMAP similar genes for TRIM7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM7: view

Variants for TRIM7 Gene

Sequence variations from dbSNP and Humsavar for TRIM7 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000065934 -- 181,205,706(-) A/G 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1000549430 -- 181,199,910(-) A/T coding_sequence_variant, downstream_transcript_variant, genic_downstream_transcript_variant, missense_variant
rs1000575997 -- 181,207,984(-) T/C upstream_transcript_variant
rs1000769245 -- 181,196,057(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000955777 -- 181,204,295(-) G/A/C 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM7 Gene

Variant ID Type Subtype PubMed ID
dgv10251n54 CNV gain 21841781
dgv5862n100 CNV gain 25217958
dgv735n27 CNV gain 19166990
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv477570 CNV novel sequence insertion 20440878
nsv517697 CNV loss 19592680
nsv600730 CNV loss 21841781
nsv600731 CNV loss 21841781
nsv830567 CNV loss 17160897

Variation tolerance for TRIM7 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM7 Gene

Disorders for TRIM7 Gene

Additional Disease Information for TRIM7

No disorders were found for TRIM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM7 Gene

Publications for TRIM7 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A … Ballabio A (The EMBO journal 2001) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Structure-function analysis of GNIP, the glycogenin-interacting protein. (PMID: 14984203) Zhai L … Roach PJ (Archives of biochemistry and biophysics 2004) 3 4 58
  4. GNIP, a novel protein that binds and activates glycogenin, the self-glucosylating initiator of glycogen biosynthesis. (PMID: 11916970) Skurat AV … Roach PJ (The Journal of biological chemistry 2002) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for TRIM7 Gene

Sources for TRIM7 Gene

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