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Aliases for TRIM7 Gene

Aliases for TRIM7 Gene

  • Tripartite Motif Containing 7 2 3 5
  • Glycogenin-Interacting Protein 2 3 4
  • Tripartite Motif Protein TRIM7 2 3
  • RING Finger Protein 90 3 4
  • RNF90 3 4
  • GNIP 3 4
  • Tripartite Motif-Containing 7 2

External Ids for TRIM7 Gene

Previous GeneCards Identifiers for TRIM7 Gene

  • GC05M180671
  • GC05P181733
  • GC05M180683
  • GC05M180739
  • GC05M180732
  • GC05M180553
  • GC05M180620
  • GC05M175348

Summaries for TRIM7 Gene

Entrez Gene Summary for TRIM7 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cytoplasm, and may represent a participant in the initiation of glycogen synthesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

GeneCards Summary for TRIM7 Gene

TRIM7 (Tripartite Motif Containing 7) is a Protein Coding gene. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM7 Gene

Genomics for TRIM7 Gene

Regulatory Elements for TRIM7 Gene

Enhancers for TRIM7 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM7 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM7 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRIM7 gene promoter:

Genomic Location for TRIM7 Gene

181,193,924 bp from pter
181,205,293 bp from pter
11,370 bases
Minus strand

Genomic View for TRIM7 Gene

Genes around TRIM7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM7 Gene

Proteins for TRIM7 Gene

  • Protein details for TRIM7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 7
    Protein Accession:
    Secondary Accessions:
    • A2RUE4
    • D3DWR7
    • Q969F5
    • Q96F67
    • Q96J89
    • Q96J90

    Protein attributes for TRIM7 Gene

    511 amino acids
    Molecular mass:
    56631 Da
    Quaternary structure:
    • Forms homodimers and heterodimers. Interacts with GYG and DES.

    Alternative splice isoforms for TRIM7 Gene


neXtProt entry for TRIM7 Gene

Proteomics data for TRIM7 Gene at MOPED

Post-translational modifications for TRIM7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for RNF90

No data available for DME Specific Peptides for TRIM7 Gene

Domains & Families for TRIM7 Gene

Gene Families for TRIM7 Gene

Suggested Antigen Peptide Sequences for TRIM7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • The B30.2 domain mediates interaction with GYG. The coiled-coil region mediates homodimerization and heterodimerization.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM7: view

Function for TRIM7 Gene

Gene Ontology (GO) - Molecular Function for TRIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TRIM7: view
genes like me logo Genes that share phenotypes with TRIM7: view

Animal Model Products

miRNA for TRIM7 Gene

miRTarBase miRNAs that target TRIM7

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM7 Gene

Localization for TRIM7 Gene

Subcellular locations from

Jensen Localization Image for TRIM7 Gene COMPARTMENTS Subcellular localization image for TRIM7 gene
Compartment Confidence
nucleus 5
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 11331580
genes like me logo Genes that share ontologies with TRIM7: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM7 Gene

Pathways & Interactions for TRIM7 Gene

SuperPathways for TRIM7 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM7 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM7 Gene

Drugs & Compounds for TRIM7 Gene

No Compound Related Data Available

Transcripts for TRIM7 Gene

Unigene Clusters for TRIM7 Gene

Tripartite motif containing 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM7 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - -
SP3: - -
SP4: - -
SP5: - - -

Relevant External Links for TRIM7 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM7 Gene

mRNA expression in normal human tissues for TRIM7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM7 Gene

This gene is overexpressed in Muscle - Skeletal (x8.8), Brain - Cerebellum (x5.6), Brain - Cerebellar Hemisphere (x4.5), and Skin - Sun Exposed (Lower leg) (x4.0).

Protein differential expression in normal tissues from HIPED for TRIM7 Gene

This gene is overexpressed in Cerebrospinal fluid (68.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM7 Gene

SOURCE GeneReport for Unigene cluster for TRIM7 Gene Hs.487412

mRNA Expression by UniProt/SwissProt for TRIM7 Gene

Tissue specificity: Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart.
genes like me logo Genes that share expression patterns with TRIM7: view

Protein tissue co-expression partners for TRIM7 Gene

Primer Products

Orthologs for TRIM7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM7 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM7 35
  • 87.88 (n)
  • 90.71 (a)
TRIM7 36
  • 91 (a)
(Canis familiaris)
Mammalia TRIM7 35
  • 86.85 (n)
  • 89.94 (a)
TRIM7 36
  • 88 (a)
(Mus musculus)
Mammalia Trim7 35
  • 86.58 (n)
  • 92.74 (a)
Trim7 16
Trim7 36
  • 93 (a)
(Rattus norvegicus)
Mammalia Trim7 35
  • 83.86 (n)
  • 88.04 (a)
(Monodelphis domestica)
Mammalia TRIM7 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM7 36
  • 75 (a)
(Pan troglodytes)
Mammalia TRIM7 36
  • 99 (a)
(Gallus gallus)
Aves TRIM7 35
  • 64.75 (n)
  • 56.19 (a)
TRIM7.1 36
  • 44 (a)
(Anolis carolinensis)
Reptilia TRIM7 36
  • 50 (a)
Species with no ortholog for TRIM7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM7 Gene

Gene Tree for TRIM7 (if available)
Gene Tree for TRIM7 (if available)

Paralogs for TRIM7 Gene

(13) SIMAP similar genes for TRIM7 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM7: view

Variants for TRIM7 Gene

Sequence variations from dbSNP and Humsavar for TRIM7 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs3857300 - 181,205,059(+) CAGCG(A/C)TAGAG upstream-variant-2KB, reference, missense
rs2770946 - 181,204,894(+) GAAGG(A/G)GGGCG upstream-variant-2KB, reference, missense
rs2770945 - 181,204,828(+) CAGCT(C/G)CCGGT upstream-variant-2KB, reference, missense
rs416574 - 181,199,927(+) TCTCA(A/G)CCCCG reference, missense
rs254460 - 181,195,615(-) TTAAG(A/G)GCGTG reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TRIM7 Gene

Variant ID Type Subtype PubMed ID
nsv428133 CNV Gain 18775914
dgv735n27 CNV Gain 19166990
nsv883305 CNV Gain 21882294
nsv830567 CNV Loss 17160897
dgv6408n71 CNV Loss 21882294
nsv883310 CNV Loss 21882294
nsv517697 CNV Loss 19592680
dgv6409n71 CNV Loss 21882294
nsv462591 CNV Loss 19166990

Variation tolerance for TRIM7 Gene

Residual Variation Intolerance Score: 61.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.65; 91.39% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM7 Gene

Disorders for TRIM7 Gene

Relevant External Links for TRIM7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM7 Gene

Publications for TRIM7 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3
  5. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PMID: 21143188) Napolitano L.M. … Meroni G. (Biochem. J. 2011) 3

Products for TRIM7 Gene

Sources for TRIM7 Gene