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Aliases for TRIM69 Gene

Aliases for TRIM69 Gene

  • Tripartite Motif Containing 69 2 3
  • RFP-Like Domain-Containing Protein Trimless 3 4
  • Ring Finger Protein 36 2 3
  • RNF36 3 4
  • Tripartite Motif-Containing Protein 69 4
  • E3 Ubiquitin-Protein Ligase TRIM69 3
  • Tripartite Motif-Containing 69 2
  • RING Finger Protein 36 4
  • EC 6.3.2.- 4
  • HSD-34 3
  • HSD34 3
  • Trif 3

External Ids for TRIM69 Gene

Previous Symbols for TRIM69 Gene

  • RNF36

Summaries for TRIM69 Gene

Entrez Gene Summary for TRIM69 Gene

  • This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM69 Gene

TRIM69 (Tripartite Motif Containing 69) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM69 Gene

  • May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM69 Gene

Genomics for TRIM69 Gene

Genomic Location for TRIM69 Gene

Start:
44,728,988 bp from pter
End:
44,767,829 bp from pter
Size:
38,842 bases
Orientation:
Plus strand

Genomic View for TRIM69 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM69 Gene

Regulatory Elements for TRIM69 Gene

Proteins for TRIM69 Gene

  • Protein details for TRIM69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WT6-TRI69_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM69
    Protein Accession:
    Q86WT6
    Secondary Accessions:
    • A8MX03
    • Q309B0
    • Q4G1A5
    • Q6W897
    • Q8IYY3
    • Q8WY16
    • Q8WY17

    Protein attributes for TRIM69 Gene

    Size:
    500 amino acids
    Molecular mass:
    57419 Da
    Quaternary structure:
    • Interacts with PML.

    Three dimensional structures from OCA and Proteopedia for TRIM69 Gene

    Alternative splice isoforms for TRIM69 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM69 Gene

Proteomics data for TRIM69 Gene at MOPED

Post-translational modifications for TRIM69 Gene

  • Phosphorylated. Phosphorylation is necessary for nuclear localization (By similarity).
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM69 Gene

Domains for TRIM69 Gene

Gene Families for TRIM69 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI69_HUMAN
Domain:
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation:
    • Q86WT6
  • Contains 1 B30.2/SPRY domain.:
    • Q86WT6
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q86WT6
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q86WT6
genes like me logo Genes that share domains with TRIM69: view

Function for TRIM69 Gene

Molecular function for TRIM69 Gene

UniProtKB/Swiss-Prot Function: May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for TRIM69 Gene

Gene Ontology (GO) - Molecular Function for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23131556
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM69: view

miRNA for TRIM69 Gene

miRTarBase miRNAs that target TRIM69

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM69 Gene

Localization for TRIM69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM69 Gene

Cytoplasm. Nucleus. Nucleus speckle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM69 Gene COMPARTMENTS Subcellular localization image for TRIM69 gene
Compartment Confidence
nucleus 5
cytosol 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 23131556
GO:0005737 cytoplasm IDA --
GO:0005886 plasma membrane IDA --
GO:0016607 nuclear speck IDA 23131556
genes like me logo Genes that share ontologies with TRIM69: view

Pathways for TRIM69 Gene

SuperPathways for TRIM69 Gene

No Data Available

UniProtKB/Swiss-Prot Q86WT6-TRI69_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM69: view

No data available for Pathways by source for TRIM69 Gene

Transcripts for TRIM69 Gene

Unigene Clusters for TRIM69 Gene

Tripartite motif containing 69:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM69 Gene

No ASD Table

Relevant External Links for TRIM69 Gene

GeneLoc Exon Structure for
TRIM69
ECgene alternative splicing isoforms for
TRIM69

Expression for TRIM69 Gene

mRNA expression in normal human tissues for TRIM69 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM69 Gene

SOURCE GeneReport for Unigene cluster for TRIM69 Gene Hs.489254

genes like me logo Genes that share expressions with TRIM69: view

Orthologs for TRIM69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM69 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM69 36
  • 99.33 (n)
  • 98.2 (a)
TRIM69 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM69 36
  • 88.6 (n)
  • 85.4 (a)
TRIM69 37
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM69 36
  • 90 (n)
  • 87.2 (a)
TRIM69 37
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim69 36
  • 84.44 (n)
  • 79.16 (a)
Trim69 16
Trim69 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM69 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM69 37
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim69 36
  • 83.77 (n)
  • 79.96 (a)
chicken
(Gallus gallus)
Aves -- 37
  • 23 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TRIM69 37
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731436 36
  • 57.52 (n)
  • 52.45 (a)
zebrafish
(Danio rerio)
Actinopterygii CU929328.1 37
  • 28 (a)
ManyToMany
Species with no ortholog for TRIM69:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM69 Gene

ENSEMBL:
Gene Tree for TRIM69 (if available)
TreeFam:
Gene Tree for TRIM69 (if available)

Paralogs for TRIM69 Gene

Selected SIMAP similar genes for TRIM69 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM69: view

Variants for TRIM69 Gene

Sequence variations from dbSNP and Humsavar for TRIM69 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type MAF
rs935888 -- 44,735,829(+) CGGGG(G/T)TGTGG upstream-variant-2KB, intron-variant
rs935889 -- 44,736,153(+) AGGCC(G/T)GTGTT upstream-variant-2KB, intron-variant
rs1060392 -- 44,733,737(+) gtctc(C/T)acctc intron-variant
rs1137516 -- 44,733,973(+) ttaac(C/G)cttta intron-variant
rs1901534 -- 44,753,351(+) gggct(C/G)aaatg intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM69 Gene

Variant ID Type Subtype PubMed ID
dgv744e1 CNV Complex 17122850
nsv832990 CNV Gain 17160897
nsv819242 CNV Loss 19587683

Relevant External Links for TRIM69 Gene

HapMap Linkage Disequilibrium report
TRIM69

Disorders for TRIM69 Gene

Relevant External Links for TRIM69

Genetic Association Database (GAD)
TRIM69
Human Genome Epidemiology (HuGE) Navigator
TRIM69
genes like me logo Genes that share disorders with TRIM69: view

No data available for UniProtKB/Swiss-Prot for TRIM69 Gene

Publications for TRIM69 Gene

  1. Forced expression of RNF36 induces cell apoptosis. (PMID: 12837286) Shyu H.W. … Li H. (Exp. Cell Res. 2003) 3 23
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49
  4. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. (PMID: 23131556) Han Y. … Wang L. (Biochem. Biophys. Res. Commun. 2012) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TRIM69 Gene

Sources for TRIM69 Gene

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