Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM69 Gene

Aliases for TRIM69 Gene

  • Tripartite Motif Containing 69 2 3 5
  • RFP-Like Domain-Containing Protein Trimless 3 4
  • RING-Type E3 Ubiquitin Transferase TRIM69 3 4
  • Ring Finger Protein 36 2 3
  • RNF36 3 4
  • Tripartite Motif-Containing Protein 69 4
  • E3 Ubiquitin-Protein Ligase TRIM69 3
  • Tripartite Motif-Containing 69 2
  • RING Finger Protein 36 4
  • EC 4
  • HSD-34 3
  • HSD34 3
  • TRIF 3

External Ids for TRIM69 Gene

Previous HGNC Symbols for TRIM69 Gene

  • RNF36

Previous GeneCards Identifiers for TRIM69 Gene

  • GC15P042815
  • GC15P045028
  • GC15P021852
  • GC15P045025
  • GC15P045027
  • GC15P045031
  • GC15P045034

Summaries for TRIM69 Gene

Entrez Gene Summary for TRIM69 Gene

  • This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM69 Gene

TRIM69 (Tripartite Motif Containing 69) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM62.

UniProtKB/Swiss-Prot for TRIM69 Gene

  • May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM69 Gene

Genomics for TRIM69 Gene

Regulatory Elements for TRIM69 Gene

Enhancers for TRIM69 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15G044723 1.8 FANTOM5 ENCODE dbSUPER 37.1 -1.1 -1067 9.7 CREB3L1 AGO1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC TBX21 MEF2D TRIM69 HNRNPMP1 EIF3J-AS1 BLOC1S6 B2M PATL2 SPG11 LOC100419583 GC15M044672
GH15G044733 1.5 Ensembl ENCODE dbSUPER 25.2 +6.9 6873 4.1 HDGF ATF1 ARNT YBX1 YY1 GATA2 NCOA1 JUNB ZNF592 SMARCA4 TRIM69 SQOR GC15P044732 ENSG00000276121
GH15G044783 1.7 FANTOM5 Ensembl ENCODE 21.5 +55.6 55624 1.7 PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 ZNF2 YY1 ZNF143 TRIM69 B2M GC15M044783 GC15M044790
GH15G044717 1.4 Ensembl ENCODE dbSUPER 23.8 -8.9 -8857 4.7 TBP PKNOX1 FOXA2 WRNIP1 BMI1 ELK1 RELB ETV6 ZNF362 SMAD5 TRIM69 GC15M044672 LOC100419583
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM69 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM69 Gene

44,728,988 bp from pter
44,767,829 bp from pter
38,842 bases
Plus strand

Genomic View for TRIM69 Gene

Genes around TRIM69 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM69 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM69 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM69 Gene

Proteins for TRIM69 Gene

  • Protein details for TRIM69 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM69
    Protein Accession:
    Secondary Accessions:
    • A8MX03
    • Q309B0
    • Q4G1A5
    • Q6W897
    • Q8IYY3
    • Q8WY16
    • Q8WY17

    Protein attributes for TRIM69 Gene

    500 amino acids
    Molecular mass:
    57419 Da
    Quaternary structure:
    • Interacts with PML.

    Three dimensional structures from OCA and Proteopedia for TRIM69 Gene

    Alternative splice isoforms for TRIM69 Gene


neXtProt entry for TRIM69 Gene

Post-translational modifications for TRIM69 Gene

  • Phosphorylated. Phosphorylation is necessary for nuclear localization.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM69 Gene

Domains & Families for TRIM69 Gene

Gene Families for TRIM69 Gene

Suggested Antigen Peptide Sequences for TRIM69 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.
  • Belongs to the TRIM/RBCC family.
  • The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear localization and aggregation.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM69: view

Function for TRIM69 Gene

Molecular function for TRIM69 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis.

Enzyme Numbers (IUBMB) for TRIM69 Gene

Gene Ontology (GO) - Molecular Function for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA,TAS --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM69: view
genes like me logo Genes that share phenotypes with TRIM69: view

Animal Model Products

CRISPR Products

miRNA for TRIM69 Gene

miRTarBase miRNAs that target TRIM69

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM69 Gene

Localization for TRIM69 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM69 Gene

Cytoplasm. Nucleus. Nucleus speckle.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM69 gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,IDA 23131556
GO:0005737 cytoplasm IEA,IDA 23131556
GO:0005829 cytosol TAS --
GO:0016607 nuclear speck IDA,IEA 23131556
genes like me logo Genes that share ontologies with TRIM69: view

Pathways & Interactions for TRIM69 Gene

genes like me logo Genes that share pathways with TRIM69: view

Pathways by source for TRIM69 Gene

UniProtKB/Swiss-Prot Q86WT6-TRI69_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM69 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination TAS --
GO:0006915 apoptotic process IEA --
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM69: view

No data available for SIGNOR curated interactions for TRIM69 Gene

Drugs & Compounds for TRIM69 Gene

No Compound Related Data Available

Transcripts for TRIM69 Gene

Unigene Clusters for TRIM69 Gene

Tripartite motif containing 69:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM69 Gene

No ASD Table

Relevant External Links for TRIM69 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM69 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM69 Gene

Protein differential expression in normal tissues from HIPED for TRIM69 Gene

This gene is overexpressed in Heart (39.5) and Urinary Bladder (28.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM69 Gene

Protein tissue co-expression partners for TRIM69 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM69 Gene:


SOURCE GeneReport for Unigene cluster for TRIM69 Gene:


Evidence on tissue expression from TISSUES for TRIM69 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with TRIM69: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM69 Gene

Orthologs for TRIM69 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM69 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM69 34 35
  • 99.33 (n)
(Canis familiaris)
Mammalia TRIM69 34 35
  • 90 (n)
(Bos Taurus)
Mammalia TRIM69 34 35
  • 88.6 (n)
(Mus musculus)
Mammalia Trim69 34 16 35
  • 84.44 (n)
(Rattus norvegicus)
Mammalia Trim69 34
  • 83.77 (n)
(Monodelphis domestica)
Mammalia TRIM69 35
  • 62 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM69 35
  • 54 (a)
(Gallus gallus)
Aves -- 35
  • 23 (a)
(Anolis carolinensis)
Reptilia TRIM69 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101731436 34
  • 57.52 (n)
(Danio rerio)
Actinopterygii CU929328.1 35
  • 28 (a)
Species where no ortholog for TRIM69 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM69 Gene

Gene Tree for TRIM69 (if available)
Gene Tree for TRIM69 (if available)

Paralogs for TRIM69 Gene

Paralogs for TRIM69 Gene

genes like me logo Genes that share paralogs with TRIM69: view

Variants for TRIM69 Gene

Sequence variations from dbSNP and Humsavar for TRIM69 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000075100 -- 44,740,343(+) AGGAA(C/T)GCAGT intron-variant
rs1000108374 -- 44,747,340(+) TTTAT(A/G)AAGAA intron-variant
rs1000113109 -- 44,753,447(+) TTTTT(C/T)TCTTT intron-variant
rs1000140840 -- 44,759,868(+) CTCTG(C/G)CCAGG reference, missense
rs1000154457 -- 44,764,087(+) TTGTA(A/G)ATGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM69 Gene

Variant ID Type Subtype PubMed ID
esv2760029 CNV gain+loss 17122850
nsv1116069 CNV deletion 24896259
nsv819242 CNV loss 19587683
nsv832990 CNV gain 17160897

Variation tolerance for TRIM69 Gene

Residual Variation Intolerance Score: 38.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.89; 79.54% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM69 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM69 Gene

Disorders for TRIM69 Gene

Relevant External Links for TRIM69

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM69 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM69 Gene

Publications for TRIM69 Gene

  1. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. (PMID: 23131556) Han Y. … Wang L. (Biochem. Biophys. Res. Commun. 2012) 3 4 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Forced expression of RNF36 induces cell apoptosis. (PMID: 12837286) Shyu H.W. … Li H. (Exp. Cell Res. 2003) 3 22 64

Products for TRIM69 Gene

Sources for TRIM69 Gene

Loading form....