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TRIM69 Gene

protein-coding   GIFtS: 50
GCID: GC15P045034

Tripartite Motif Containing 69

(Previous names: ring finger protein 36, tripartite motif-containing 69)
(Previous symbol: RNF36)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 691 2     HSD342
RING Finger Protein 361 2 3     Trif2
RNF361 2 3     E3 Ubiquitin-Protein Ligase TRIM692
RFP-Like Domain-Containing Protein Trimless2 3     EC 6.3.2.-3
Tripartite Motif-Containing 691     Tripartite Motif-Containing Protein 693

External Ids:    HGNC: 178571   Entrez Gene: 1406912   Ensembl: ENSG000001858807   UniProtKB: Q86WT63   

Export aliases for TRIM69 gene to outside databases

Previous GC identifers: GC15P042815 GC15P045028 GC15P021852 GC15P045025 GC15P045027 GC15P045031


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM69 Gene:
This gene encodes a member of the RING-B-box-coiled-coil (RBCC) family and encodes a protein with an N-terminal
RING finger motif, a PRY domain and a C-terminal SPRY domain. The mouse ortholog of this gene is specifically
expressed in germ cells at the round spermatid stages during spermatogenesis and, when overexpressed, induces
apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TRIM69 Gene:
TRIM69 (tripartite motif containing 69) is a protein-coding gene. Diseases associated with TRIM69 include narcolepsy. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is TRIM31.

UniProtKB/Swiss-Prot: TRI69_HUMAN, Q86WT6
Function: May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NT_187605.1  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM69 gene promoter:
         AML1a   RelA   NF-kappaB   E47   GATA-1   GATA-6   c-Myb   Hand1   TGIF   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM69 promoter sequence
   Search Chromatin IP Primers for TRIM69

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM69


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.1   Ensembl cytogenetic band:  15q21.1   HGNC cytogenetic band: 15q15-q21

TRIM69 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM69 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P045034:  view genomic region     (about GC identifiers)

Start:
45,021,186 bp from pter      End:
45,060,027 bp from pter
Size:
38,842 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI69_HUMAN, Q86WT6 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM69  
Size: 500 amino acids; 57419 Da
Subunit: Interacts with PML (By similarity)
Secondary accessions: A8MX03 Q309B0 Q4G1A5 Q6W897 Q8IYY3 Q8WY16 Q8WY17
Alternative splicing: 4 isoforms:  Q86WT6-1   Q86WT6-2   Q86WT6-3   Q86WT6-4   

Explore the universe of human proteins at neXtProt for TRIM69: NX_Q86WT6

Explore proteomics data for TRIM69 at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation is necessary for nuclear localization (By similarity)1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM69 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_542783.2  NP_892030.3  

    ENSEMBL proteins: 
     ENSP00000453177   ENSP00000453549   ENSP00000453332   ENSP00000453077   ENSP00000342922  
     ENSP00000452855   ENSP00000452739   ENSP00000332284  

    TRIM69 Human Recombinant Protein Products:

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    Novus Biologicals TRIM69 Proteins
    Novus Biologicals TRIM69 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM69

    TRIM69 Antibody Products:

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    TRIM69 Assay Products:

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    Cloud-Clone Corp. ELISAs for TRIM69
    Cloud-Clone Corp. CLIAs for TRIM69


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q86WT6

    ProtoNet protein and cluster: Q86WT6

    3 Blocks protein domains:
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI69_HUMAN, Q86WT6
    Domain: The RING-type zinc finger domain is responsible for E3 ubiquitin ligase activity and for nuclear
    localization and aggregation
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM69 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI69_HUMAN, Q86WT6
    Function: May have E3 ubiquitin-protein ligase activity. May play a role in apoptosis

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM69 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM69
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM69
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM69

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM69:
    hsa-mir-335-5p (MIRT018647)

    Block miRNA regulation of human, mouse, rat TRIM69 using miScript Target Protectors
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM69

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM69 (NM_182985)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM69

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM69 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM69


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI69_HUMAN, Q86WT6: Cytoplasm. Nucleus. Nucleus speckle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    plasma membrane1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005737cytoplasm IDA--
    GO:0016607nuclear speck IDA--

    TRIM69 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TRI69_HUMAN, Q86WT6
    Pathway: Protein modification; protein ubiquitination

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM69
    Interactions:

        Search GeneGlobe Interaction Network for TRIM69

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for TRIM69 (Q86WT62, 3 ENSP000003322844) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAGEA4P433582, 3, ENSP000002763444MINT-67646 I2D: score=5 STRING: ENSP00000276344
    PMLP295903, ENSP000002680584I2D: score=2 STRING: ENSP00000268058
    TLR3O154553, ENSP000002967954I2D: score=1 STRING: ENSP00000296795
    TLR4O002063, ENSP000003630894I2D: score=1 STRING: ENSP00000363089
    TLR9Q9NR963, ENSP000003538744I2D: score=1 STRING: ENSP00000353874
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--

    TRIM69 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM69 (TRI69)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM69 gene (2 alternative transcripts): 
    NM_080745.3  NM_182985.3  

    Unigene Cluster for TRIM69:

    Tripartite motif containing 69
    Hs.489254  [show with all ESTs]
    Unigene Representative Sequence: BC031266
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559390(uc001zuf.2 uc001zug.1 uc001zuh.1 uc001zui.1 uc010bdy.1)
    ENST00000560141(uc001zue.3) ENST00000560554 ENST00000559315 ENST00000561237
    ENST00000560442 ENST00000558329 ENST00000561043 ENST00000338264 ENST00000558173
    ENST00000561170 ENST00000329464
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate TRIM69
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM69
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM69 (NM_182985)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM69
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM69
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM69
      QuantiFast Probe-based Assays in human, mouse, rat TRIM69

    Additional mRNA sequence: 

    AK311550.1 BC031266.1 

    5 DOTS entries:

    DT.113579  DT.121080066  DT.92048039  DT.95269722  DT.91713472 

    Selected AceView cDNA sequences (see all 5611):

    BQ631628 BM760036 BM353270 CB985694 AA344362 BM818308 BM970121 BM787486 
    AA360497 CA947049 BU657343 AW089594 BM845294 BQ015475 AA380296 AA650578 
    BM760704 AI919530 CR608139 BG679565 CR590254 AA283298 BU629461 CA417002 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM69 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCCTACA
    TRIM69 Expression
    About this image

    TRIM69 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM69 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.489254
        Custom PCR Arrays for TRIM69
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM69

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM69 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim691 , 5 tripartite motif-containing 691, 5 84.44(n)1
    79.16(a)1
      2 (60.55 cM)5
    709281  NM_080510.21  NP_536771.21 
     1221607005 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    23(a)
    many ↔ many
    13(12660059-12664982)
    lizard
    (Anolis carolinensis)
    Reptilia TRIM696
    tripartite motif containing 69
    49(a)
    1 ↔ 1
    GL343490.1(352282-359290)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1377116702   -- 70.73(n)    137711670 
    zebrafish
    (Danio rerio)
    Actinopterygii CU929328.16
    Uncharacterized protein
    28(a)
    many ↔ many
    16(12007190-12013650) ENSDARG00000058262


    ENSEMBL Gene Tree for TRIM69 (if available)
    TreeFam Gene Tree for TRIM69 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM69 gene
    TRIM312  TRIM502  TRIM102  TRIM732  TRIM152  TRIM262  TRIM742  TRIM352  
    TRIM522  TRIM622  TRIM412  TRIM722  
    Selected SIMAP similar genes for TRIM69 using alignment to 3 protein entries:     TRI69_HUMAN (see all proteins) (see all similar genes):
    ERMAP    BTN2A2    MEFV    TRIM41    TRIM27    BTN3A3
    TRIM11    TRIM39    BT3.3    TRIM21    BTNL8    TRIM68
    TRIM26    TRIM62    TRIM38    TRIM60    BTNL9    TRIM10

    TRIM69 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM69 (see all 799)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3741624211,2
    C--21869908(+) ATTCC-/TT    
       TTTTT
    TTTTT
    2 -- int10--------
    rs1385555081,2
    C--45026619(+) AGGGTA/CTCGCC 2 -- us2k10--------
    rs1140487861,2
    F--45026869(+) GACACC/TCATAG 2 -- us2k11Minor allele frequency- T:0.03WA 118
    rs49239931,2
    C,F,A,H--45026900(+) GGCTAC/TTCAGT 2 -- us2k136Minor allele frequency- T:0.10NS EA NA WA CSA 3407
    rs352772591,2
    C--45026910(+) TGCTCTGG/-TGGTG 2 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs570553361,2
    C--45026912(+) TGGTG-/GTGAGAGA 2 -- us2k11Minor allele frequency- GTG:0.00NA 2
    rs1908643651,2
    --45026951(+) GTACTC/TTTACC 2 -- us2k10--------
    rs1427512061,2
    --45026978(+) AAAAAC/TGTGCA 2 -- us2k10--------
    rs349674371,2
    C--45027043(+) CAAAA-/ACAATC 2 -- us2k12Minor allele frequency- A:0.25NA CSA 4
    rs1469387641,2
    C--45027156(+) AAGGTC/GAGCAA 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM69 (45021186 - 45060027 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM69:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819242CNV Loss19587683
    nsv832990CNV Gain17160897
    dgv744e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM69
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM69

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TRIM69:    About MalaCards
    narcolepsy


    TRIM69 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM69
    Human Genome Epidemiology (HuGE) Navigator: TRIM69 (2 documents)

    Export disorders for TRIM69 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM69 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TRIM69)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. (PubMed id 23131556)1, 2 Han Y.... Wang L. (Biochem. Biophys. Res. Commun. 2012)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Forced expression of RNF36 induces cell apoptosis. (PubMed id 12837286)1, 9 Shyu H.W....Li H. (Exp. Cell Res. 2003)
    6. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PubMed id 23824909)1 Chen Y....Ge F. (amp 2013)
    7. E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. (PubMed id 21911421)1 Yang M....Chen T. (J. Exp. Med. 2011)
    8. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (J. Biol. Chem. 2011)
    9. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PubMed id 20360068)1 Hutchins J.R.... Peters J.M. (Science 2010)
    10. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)2 Zody M.C....Nusbaum C. (Nature 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 140691 HGNC: 17857 AceView: B2MandRNF36andLOC400368 Ensembl:ENSG00000185880 euGenes: HUgn140691
    ECgene: TRIM69 H-InvDB: TRIM69

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM69 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM69 gene:
    Search GeneIP for patents involving TRIM69

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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