Aliases for TRIM68 Gene
External Ids for TRIM68 Gene
Previous HGNC Symbols for TRIM68 Gene
Previous GeneCards Identifiers for TRIM68 Gene
This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
GeneCards Summary for TRIM68 Gene
TRIM68 (Tripartite Motif Containing 68) is a Protein Coding gene. Diseases associated with TRIM68 include Prostate Cancer and Systemic Lupus Erythematosus. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Interferon gamma signaling. GO annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is TRIM21.
UniProtKB/Swiss-Prot for TRIM68 Gene
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.