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Aliases for TRIM68 Gene

Aliases for TRIM68 Gene

  • Tripartite Motif Containing 68 2 3 5
  • Tripartite Motif-Containing Protein 68 3 4
  • Ring Finger Protein 137 2 3
  • SSA Protein SS-56 3 4
  • RNF137 3 4
  • GC109 3 4
  • SS-56 3 4
  • SS56 3 4
  • Tripartite Motif-Containing 68 2
  • Ro/SSA1 Related Protein 3
  • RING Finger Protein 137 4
  • EC 6.3.2.- 4

External Ids for TRIM68 Gene

Previous HGNC Symbols for TRIM68 Gene

  • RNF137

Previous GeneCards Identifiers for TRIM68 Gene

  • GC11M004278

Summaries for TRIM68 Gene

Entrez Gene Summary for TRIM68 Gene

  • This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

GeneCards Summary for TRIM68 Gene

TRIM68 (Tripartite Motif Containing 68) is a Protein Coding gene. Diseases associated with TRIM68 include Prostate Cancer and Systemic Lupus Erythematosus. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include ligase activity and androgen receptor binding. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM68 Gene

  • Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.

Gene Wiki entry for TRIM68 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM68 Gene

Genomics for TRIM68 Gene

Regulatory Elements for TRIM68 Gene

Enhancers for TRIM68 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM68 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM68 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM68 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM68 Gene

4,598,672 bp from pter
4,608,259 bp from pter
9,588 bases
Minus strand

Genomic View for TRIM68 Gene

Genes around TRIM68 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM68 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM68 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM68 Gene

Proteins for TRIM68 Gene

  • Protein details for TRIM68 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM68
    Protein Accession:
    Secondary Accessions:
    • A6NI19
    • A8K551
    • B3KPM5
    • B4DVK4
    • Q8WZ70
    • Q96LE5
    • Q96PF7
    • Q9H9C2
    • Q9NW18

    Protein attributes for TRIM68 Gene

    485 amino acids
    Molecular mass:
    56259 Da
    Quaternary structure:
    • Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60.
    • Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary Sjoegren syndrome.
    • Sequence=BAA91569.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB14309.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM68 Gene


neXtProt entry for TRIM68 Gene

Proteomics data for TRIM68 Gene at MOPED

Post-translational modifications for TRIM68 Gene

Other Protein References for TRIM68 Gene

No data available for DME Specific Peptides for TRIM68 Gene

Domains & Families for TRIM68 Gene

Gene Families for TRIM68 Gene

Suggested Antigen Peptide Sequences for TRIM68 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The RING domain is essential for ubiquitin E3 ligase activity.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • The RING domain is essential for ubiquitin E3 ligase activity.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM68: view

Function for TRIM68 Gene

Molecular function for TRIM68 Gene

UniProtKB/Swiss-Prot Function:
Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
UniProtKB/Swiss-Prot Induction:
Up-regulated in prostate cancer.

Enzyme Numbers (IUBMB) for TRIM68 Gene

Gene Ontology (GO) - Molecular Function for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 18451177
GO:0016874 ligase activity IEA --
GO:0035035 histone acetyltransferase binding IPI 18451177
GO:0050681 androgen receptor binding IPI 18451177
genes like me logo Genes that share ontologies with TRIM68: view
genes like me logo Genes that share phenotypes with TRIM68: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM68 Gene

Localization for TRIM68 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM68 Gene

Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus.

Subcellular locations from

Jensen Localization Image for TRIM68 Gene COMPARTMENTS Subcellular localization image for TRIM68 gene
Compartment Confidence
cytosol 5
golgi apparatus 5
nucleus 5

Gene Ontology (GO) - Cellular Components for TRIM68 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18451177
GO:0005730 nucleolus IDA --
GO:0048471 perinuclear region of cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIM68: view

Pathways & Interactions for TRIM68 Gene

genes like me logo Genes that share pathways with TRIM68: view

Pathways by source for TRIM68 Gene

UniProtKB/Swiss-Prot Q6AZZ1-TRI68_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM68 Gene


No data available for SIGNOR curated interactions for TRIM68 Gene

Drugs & Compounds for TRIM68 Gene

No Compound Related Data Available

Transcripts for TRIM68 Gene

Unigene Clusters for TRIM68 Gene

Tripartite motif containing 68:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM68 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
SP1: -
SP2: -

Relevant External Links for TRIM68 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM68 Gene

mRNA expression in normal human tissues for TRIM68 Gene

Protein differential expression in normal tissues from HIPED for TRIM68 Gene

This gene is overexpressed in Colon muscle (66.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM68 Gene

SOURCE GeneReport for Unigene cluster for TRIM68 Gene Hs.523438

mRNA Expression by UniProt/SwissProt for TRIM68 Gene

Tissue specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells.
genes like me logo Genes that share expression patterns with TRIM68: view

Protein tissue co-expression partners for TRIM68 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TRIM68 Gene

Orthologs for TRIM68 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TRIM68 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM68 35
  • 87.84 (n)
  • 88.25 (a)
TRIM68 36
  • 85 (a)
(Canis familiaris)
Mammalia TRIM68 35
  • 89.07 (n)
  • 88.66 (a)
TRIM68 36
  • 76 (a)
(Mus musculus)
Mammalia Trim68 35
  • 80.99 (n)
  • 78.1 (a)
Trim68 16
Trim68 36
  • 78 (a)
(Pan troglodytes)
Mammalia TRIM68 35
  • 99.31 (n)
  • 99.18 (a)
TRIM68 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim68 35
  • 81.32 (n)
  • 76.34 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 30 (a)
-- 36
  • 39 (a)
-- 36
  • 35 (a)
-- 36
  • 34 (a)
-- 36
  • 35 (a)
Species with no ortholog for TRIM68:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM68 Gene

Gene Tree for TRIM68 (if available)
Gene Tree for TRIM68 (if available)

Paralogs for TRIM68 Gene

genes like me logo Genes that share paralogs with TRIM68: view

Variants for TRIM68 Gene

Sequence variations from dbSNP and Humsavar for TRIM68 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2231975 - 4,600,409(-) TGACT(A/G)TGGCT reference, missense
rs2231976 - 4,600,364(-) TGGGC(A/G)CCTCC reference, missense
rs7109316 - 4,600,337(+) TGCTG(C/G/T)AGCAA reference, missense
rs931811 -- 4,602,558(-) AAGCT(A/G)GGAAA intron-variant
rs986535 -- 4,609,693(-) ATAAA(C/G)AAACA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM68 Gene

Variant ID Type Subtype PubMed ID
nsv896911 CNV Gain 21882294
nsv832055 CNV Loss 17160897
nsv896914 CNV Gain 21882294

Variation tolerance for TRIM68 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.47; 28.76% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM68 Gene

Disorders for TRIM68 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM68 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
prostate cancer
  • prostate cancer, hereditary, 5
systemic lupus erythematosus
  • lupus nephritis
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM68

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM68: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM68 Gene

Publications for TRIM68 Gene

  1. A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. (PMID: 11597395) Chang G.T. … Brinkmann A.O. (Eur. J. Cancer 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TRIM68 negatively regulates IFN-I^ production by degrading TRK fused gene, a novel driver of IFN-I^ downstream of anti-viral detection systems. (PMID: 24999993) Wynne C. … Jefferies C.A. (PLoS ONE 2014) 3
  4. Epigenetic deregulation of miR-29a and miR-1256 by isoflavone contributes to the inhibition of prostate cancer cell growth and invasion. (PMID: 22805767) Li Y. … Sarkar F.H. (Epigenetics 2012) 3
  5. TRIM proteins and cancer. (PMID: 21979307) Hatakeyama S. (Nat. Rev. Cancer 2011) 3

Products for TRIM68 Gene

Sources for TRIM68 Gene