TRIM68 Gene
protein-coding GIFtS: 49
GCID: GC11M004577
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tripartite motif containing 68(Previous names: ring finger protein 137, tripartite motif-containing 68...) (Previous symbol: RNF137)
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Aliases for TRIM68 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 681 2 | | Tripartite Motif-Containing Protein 682 3 | | RING Finger Protein 1371 2 3 | | SSA Protein SS-562 3 | | RNF1371 2 3 | | FLJ103691 | | SS-561 2 3 | | E3 Ubiquitin-Protein Ligase TRIM682 | | GC1092 3 5 | | Ro/SSA1 Related Protein2 | | SS562 3 5 | | EC 6.3.2.-3 | | Tripartite Motif-Containing 681 2 | | |
Export aliases for TRIM68 gene to outside databasesPrevious GC identifer: GC11M004278 |
Summaries for TRIM68 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| Entrez Gene summary for TRIM68: This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in manycancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene wasalso found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells.(provided by RefSeq, Oct 2011) UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1Function: Functions as an ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on itsubiquitin ligase activity Gene Wiki entry for TRIM68
|
Genomic Views for TRIM68 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TRIM68 gene promoter: GR NF-1 NF-1/L GR-beta MyoD GR-alpha AP-4 NRSF form 2 Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM68
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM68 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4TRIM68 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M004577: view genomic region
(about GC identifiers)
Start:
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4,619,902 bp from pter |
End:
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4,629,489 bp from pter |
Size:
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9,588 bases |
Orientation:
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minus strand |
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Proteins for TRIM68 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1 (See
protein sequence)Recommended Name: E3 ubiquitin-protein ligase TRIM68 Size: 485 amino acids; 56259 Da
Subunit: Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60
Subcellular location: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus
Miscellaneous: Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primarySjoegren syndrome
Sequence caution: Sequence=BAA91569.1; Type=Erroneous initiation; Sequence=BAB14309.1; Type=Erroneous initiation;
Secondary accessions: A6NI19 A8K551 B3KPM5 Q8WZ70 Q96LE5 Q96PF7 Q9H9C2 Q9NW18Explore the universe of human proteins at neXtProt for TRIM68: NX_Q6AZZ1
Post-translational modifications:
Auto-ubiquitinated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6AZZ1 TRIM68 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_060543.5 ENSEMBL proteins: ENSP00000300747 ENSP00000431783 ENSP00000434681 ENSP00000436112 Human Recombinant Protein Products:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TRIM68 for ontologies About GeneDecksing
TRIM68 Antibody Products: Assay Products for TRIM68: |
Protein
Domains / Families for TRIM68 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM68 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q6AZZ1ProtoNet protein and cluster: Q6AZZ1 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1Domain: The RING domain is essential for ubiquitin E3 ligase activitySimilarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function for TRIM68 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
| Function Summary: UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1Function: Functions as an ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on itsubiquitin ligase activityInduction: Up-regulated in prostate cancerEnzyme Number (IUBMB): EC 6.3.2.-1
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM68 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM68 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM68 (NM_018073) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM68 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM68  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM68 |
Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table
TRIM68 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TRIM68:
|
Pathways & Interactions for TRIM68 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1Pathway: Protein modification; protein ubiquitinationInteractions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM68
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
 4 Interacting proteins for TRIM68 (Q6AZZ13 ENSP000003007474) via UniProtKB, MINT, STRING, and/or I2D About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TRIM68 for ontologies About GeneDecksing
|
Drugs & Compounds for TRIM68 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TRIM68 Search CenterWatch for drugs/clinical trials and news about TRIM68 / TRI68 
|
Transcripts for TRIM68 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TRIM68 gene: NM_018073.6 Unigene Cluster for TRIM68: Tripartite motif containing 68 Hs.523438 [show with all ESTs]Unigene Representative Sequence: NM_0180737 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000300747(uc001lzf.2 uc010qyj.2) ENST00000531101 ENST00000526337 ENST00000531717 ENST00000531644 ENST00000532108(uc009yek.2) ENST00000533021
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM68 (see all 2) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM68 OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM68 (NM_018073) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM68 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM68  |
Additional cDNA sequence: AF360739.1 AF439153.1 AK001231.1 AK022923.1 AK056523.1 AK291166.1 AK301120.1 AK310888.1 AL832730.1 AY005802.1 BC075058.2 BC109063.2 5 DOTS entries: DT.75157640 DT.120723693 DT.100773686 DT.441571 DT.91756173 24/64 AceView cDNA sequences (see all 64): BF195728 AW294298 N39251 BU726330 AA595261 BC075058 AW438826 AI858536 AA576931 AF439153 CR605215 NM_018073 W68593 BM548233 BX454582 CD628937 BU194619 AF360739 CF144686 BE867271 AW274746 AU128493 AK001231 AU124051 GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM68 About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | |
| SP1: | |   | |   | |   | |   | |   | - |   | |   | |   | |
| SP2: | |   | - |   | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TRIM68
|
Expression for TRIM68 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM68 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: TATGTAGGAG
About this image See TRIM68 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TRIM68
SOURCE GeneReport for Unigene cluster: Hs.523438 UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1Tissue specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could berestricted to androgen-dependent cells SABiosciences Expression via Pathway-Focused PCR Array including TRIM68:
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM68 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM68 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM68 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM68 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM68 |
Orthologs for TRIM68 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM68 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic classification |
Gene |
Description |
Human Similarity |
Orthology Type |
Details |
lizard (Anolis carolinensis) |
Reptilia |
TRIM586 |
-- |
40(a) |
1 → many |
GL343252.1(1250786-1269672) |
zebrafish (Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
22(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM68 (if available) TreeFam Gene Tree for TRIM68 (if available)  |
Paralogs for TRIM68 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
| Paralogs for TRIM68 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM582
- TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/44 SIMAP similar genes for TRIM68 using alignment to 4 protein entries: TRI68_HUMAN (see all proteins)
(see all similar genes):ERMAP TRIM21 TRIM5 BT3.3 TRIM22 TRIM58 TRIM6 TRIM27 TRIM41 DKFZp686F23130 TRIM60 TRIM26 TRIM39 TRIM17 TRIM11 TRIM38 TRIM31 BTNL9
TRIM68 for paralogs About GeneDecksing
|
Genomic Variants for TRIM68 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 11 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TRIM68 (4619902 - 4629489 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TRIM68: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM68 |
|
Disorders
/ Diseases for TRIM68 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM68 for disorders About GeneDecksing
OMIM gene information: 613184
OMIM disorders: --
6 diseases for TRIM68: About MalaCardsprostate cancer prostatitis systemic lupus erythematosus lupus erythematosus sjogren's syndrome nephropathy Human Genome Epidemiology (HuGE) Navigator: TRIM68 (1 document) Export disorders for TRIM68 gene to outside databases
|
Publications for TRIM68 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM68 gene, integrated from 9 sources (see all 19): (articles sorted by number of sources associating them with TRIM68) | |  | Utopia: connect your pdf to the dynamic world of online information |
- A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. (PubMed id 11597395)1, 2, 3 Chang G.T.... Brinkmann A.O. (2001)
- TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. (PubMed id 18451177)1, 2 Miyajima N....Hatakeyama S. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus. (PubMed id 11560955)1, 2 Billaut-Mulot O.... Bahr G.M. (2001)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Genome-wide linkage scans for type 2 diabetes mellitu s in four ethnically diverse populations-significant evidence for linkage on ch romosome 4q in African Americans: the Family Investigation of Nephropathy and D iabetes Research Group. (PubMed id 19795399)1 Malhotra A....Hanson R.L. (2009)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
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External Searches for TRIM68 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing TRIM68 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM68 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM68 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
|
About This Section
| Patent Information for TRIM68 gene: Search GeneIP for patents involving TRIM68
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TRIM68 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
|
 | |
 | |
 |
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 | | TRIM68 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM68 |
|  |  |  | | | Search ThermoFisher Antibodies for TRIM68 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM68 |
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