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TRIM68 Gene

protein-coding   GIFtS: 55
GCID: GC11M004577

Tripartite Motif Containing 68

(Previous names: ring finger protein 137, tripartite motif-containing 68)
(Previous symbol: RNF137)
  See TRIM68-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 681 2     Tripartite Motif-Containing Protein 682 3
RING Finger Protein 1371 2 3     SS-562 3
RNF1371 2 3     SSA Protein SS-562 3
GC1092 3 5     E3 Ubiquitin-Protein Ligase TRIM682
SS562 3 5     Ro/SSA1 Related Protein2
Tripartite Motif-Containing 681 2     EC 6.3.2.-3

External Ids:    HGNC: 211611   Entrez Gene: 551282   Ensembl: ENSG000001673337   OMIM: 6131845   UniProtKB: Q6AZZ13   

Export aliases for TRIM68 gene to outside databases

Previous GC identifer: GC11M004278


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM68 Gene:
This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally
distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is
expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to
prostate. This gene was also found to be differentially expressed in androgen-dependent versus
androgen-independent prostate cancer cells. (provided by RefSeq, Oct 2011)

GeneCards Summary for TRIM68 Gene:
TRIM68 (tripartite motif containing 68) is a protein-coding gene. Diseases associated with TRIM68 include prostate cancer. GO annotations related to this gene include ubiquitin-protein ligase activity and histone acetyltransferase binding. An important paralog of this gene is TRIM7.

UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1
Function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its
ubiquitin ligase activity

Gene Wiki entry for TRIM68 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_009237.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM68 gene promoter:
         GR   NF-1   NF-1/L   GR-beta   MyoD   GR-alpha   AP-4   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM68 promoter sequence
   Search Chromatin IP Primers for TRIM68

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM68


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

TRIM68 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM68 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M004577:  view genomic region     (about GC identifiers)

Start:
4,619,902 bp from pter      End:
4,629,489 bp from pter
Size:
9,588 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM68  
Size: 485 amino acids; 56259 Da
Subunit: Interacts with AR/androgen receptor (via ligand-binding domain). Interacts with KAT5/TIP60
Miscellaneous: Antibodies against TRIM68 are found in patients with systemic lupus erythematosus (SLE) and primary
Sjoegren syndrome
Sequence caution: Sequence=BAA91569.1; Type=Erroneous initiation; Sequence=BAB14309.1; Type=Erroneous initiation;
Secondary accessions: A6NI19 A8K551 B3KPM5 Q8WZ70 Q96LE5 Q96PF7 Q9H9C2 Q9NW18

Explore the universe of human proteins at neXtProt for TRIM68: NX_Q6AZZ1

Explore proteomics data for TRIM68 at MOPED

Post-translational modifications: 

  • Auto-ubiquitinated1
  • Ubiquitination2 at Lys81
  • Modification sites at PhosphoSitePlus

  • See TRIM68 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060543.5  
    ENSEMBL proteins: 
     ENSP00000300747   ENSP00000431783   ENSP00000434681   ENSP00000436112  

    TRIM68 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIM68

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q6AZZ1

    ProtoNet protein and cluster: Q6AZZ1

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1
    Domain: The RING domain is essential for ubiquitin E3 ligase activity
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM68           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI68_HUMAN, Q6AZZ1
    Function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its
    ubiquitin ligase activity
    Induction: Up-regulated in prostate cancer

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IDA18451177
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0035035histone acetyltransferase binding IPI18451177
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with TRIM68           About GenesLikeMe


    Phenotypes:
         3 GenomeRNAi human phenotypes for TRIM68:
     Increased G1 DNA content  Increased HPV18 LCR reporter a  Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM68
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM68
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM68

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM68:
    hsa-mir-26b-5p (MIRT030315), hsa-mir-192-5p (MIRT026905), hsa-mir-215-5p (MIRT024356)

    Block miRNA regulation of human, mouse, rat TRIM68 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TRIM68:
    hsa-miR-24 hsa-miR-3647-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTRIM68 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM68
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM68

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TRIM68

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    OriGene ORF clones in mouse, rat for TRIM68
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM68 (NM_018073)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM68
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM68

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM68 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM68


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI68_HUMAN, Q6AZZ1: Cytoplasm, perinuclear region. Nucleus. Note=Colocalized with AR in nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    golgi apparatus4
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IDA--
    GO:0005794Golgi apparatus IDA--

    Find genes that share ontologies with TRIM68           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM68: 

              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM68

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for TRIM68 (Q6AZZ13 ENSP000003007474) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    ARP102753, ENSP000003638224I2D: score=1 STRING: ENSP00000363822
    KAT5Q929933, ENSP000003403304I2D: score=1 STRING: ENSP00000340330
    UBCENSP000003448184STRING: ENSP00000344818
    MYOD1ENSP000002500034STRING: ENSP00000250003
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0051865protein autoubiquitination IDA18451177
    GO:0060765regulation of androgen receptor signaling pathway IDA18451177

    Find genes that share ontologies with TRIM68           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM68 (TRI68)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM68 gene: 
    NM_018073.6  

    Unigene Cluster for TRIM68:

    Tripartite motif containing 68
    Hs.523438  [show with all ESTs]
    Unigene Representative Sequence: NM_018073
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300747(uc001lzf.2 uc010qyj.2) ENST00000531101 ENST00000526337
    ENST00000531717 ENST00000531644 ENST00000532108(uc009yek.2) ENST00000533021

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM68 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TRIM68:
    hsa-miR-24 hsa-miR-3647-3p hsa-miR-4267
    SwitchGear 3'UTR luciferase reporter plasmidTRIM68 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM68
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM68
    Clone
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    OriGene ORF clones in mouse, rat for TRIM68
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM68 (NM_018073)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM68
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM68
    Primer
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    OriGene qPCR primer pairs and template standards for TRIM68
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM68
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM68
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM68
      QuantiFast Probe-based Assays in human, mouse, rat TRIM68

    Additional mRNA sequence: 

    AF360739.1 AF439153.1 AK001231.1 AK022923.1 AK056523.1 AK291166.1 AK301120.1 AK310888.1 
    AL832730.1 AY005802.1 BC075058.2 BC109063.2 

    5 DOTS entries:

    DT.75157640  DT.120723693  DT.441571  DT.100773686  DT.91756173 

    Selected AceView cDNA sequences (see all 64):

    AI858536 AA595261 AW438826 BC075058 BU726330 AA576931 CR605215 BF195728 
    AF439153 N39251 AW294298 NM_018073 BU608835 W70192 AK056523 AU128493 
    BG752181 AU124051 AK001231 AA364882 AW274746 W68592 AL832730 BX327429 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM68    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7
    SP1:                                -               
    SP2:        -                                       


    ECgene alternative splicing isoforms for TRIM68

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM68 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TATGTAGGAG
    TRIM68 Expression
    About this image


    TRIM68 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Pancreas (Endocrine System)
             Islets of Langerhans
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
    TRIM68 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM68 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.523438

    UniProtKB/Swiss-Prot: TRI68_HUMAN, Q6AZZ1
    Tissue specificity: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could
    be restricted to androgen-dependent cells

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM68: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TRIM68
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM68

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TRIM68 gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim681 , 5 tripartite motif-containing 681, 5 80.99(n)1
    78.1(a)1
      7 (54.80 cM)5
    1017001  NM_198012.21  NP_932129.21 
     1026775805 


    ENSEMBL Gene Tree for TRIM68 (if available)
    TreeFam Gene Tree for TRIM68 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM68 gene
    TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM602  
    TRIM222  TRIM172  TRIM52  TRIM62  TRIM6-TRIM342  TRIM212  TRIM382  TRIM112  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM68 using alignment to 4 protein entries:     TRI68_HUMAN (see all proteins) (see all similar genes):
    ERMAP    TRIM21    TRIM5    BT3.3    TRIM22    TRIM58
    TRIM6    TRIM41    TRIM11    DKFZp686F23130    TRIM39    TRIM60
    TRIM26    TRIM31    TRIM17    TRIM38    BTNL9    TRIM34

    Find genes that share paralogs with TRIM68           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM68 (see all 376)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1490594471,2
    Cuntested14621686(+) TCCACG/AAAGAT 2 /F syn11Minor allele frequency- A:0.00NA 4552
    rs122826611,2
    C,F,A,H--4619424(+) CTGGTC/TGTAAA 1 -- int15Minor allele frequency- T:0.03NS EA NA 540
    rs1892891491,2
    --4619437(+) TCAGAC/TAATCT 1 -- int10--------
    rs1819052561,2
    --4619502(+) CCAAAC/GAGGCT 1 -- int10--------
    rs18760261,2
    C,A,H--4619532(-) TGGTTA/GGTTTG 1 -- int113Minor allele frequency- G:0.07NA WA CSA EA 378
    rs781651631,2
    C,F--4619543(+) AAAAGA/CGTACA 1 -- int12Minor allele frequency- C:0.06WA NA 238
    rs1849897371,2
    --4619544(+) AAAGAA/GTACAT 1 -- int10--------
    rs672618731,2
    C,F--4619666(+) CAACAT/CTGATT 1 -- int15Minor allele frequency- C:0.11NA WA 244
    rs342825981,2
    C,F--4619690(+) TTTGTC/GCCAAT 1 -- int17Minor allele frequency- G:0.11NA WA CSA EA 366
    rs1903311641,2
    C--4619694(+) TCCCAA/GTTGTC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM68 (4619902 - 4629489 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM68:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832055CNV Loss17160897
    nsv896914CNV Gain21882294
    nsv896911CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM68
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM68

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613184    OMIM disorders: --

    1 disease for TRIM68:    
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    prostate cancer


    Find genes that share disorders with TRIM68           About GenesLikeMe

    Genetic Association Database (GAD): TRIM68
    Human Genome Epidemiology (HuGE) Navigator: TRIM68 (1 document)

    Export disorders for TRIM68 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM68 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TRIM68)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel gene on human chromosome 2p24 is differentially expressed between androgen-dependent and androgen-independent prostate cancer cells. (PubMed id 11597395)1, 2, 3 Chang G.T.... Brinkmann A.O. (Eur. J. Cancer 2001)
    2. Genome-wide linkage scans for type 2 diabetes mellitus in four ethnically diverse populations-significant evidence for linkage on chromosome 4q in African Americans: the Family Investigation of Nephropathy and Diabetes Research Group. (PubMed id 19795399)1, 4 Malhotra A....Hanson R.L. (Diabetes Metab. Res. Rev. 2009)
    3. TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells. (PubMed id 18451177)1, 2 Miyajima N.... Hatakeyama S. (Cancer Res. 2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. SS-56, a novel cellular target of autoantibody responses in Sjogren syndrome and systemic lupus erythematosus. (PubMed id 11560955)1, 2 Billaut-Mulot O.... Bahr G.M. (J. Clin. Invest. 2001)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    10. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55128 HGNC: 21161 AceView: RNF137 Ensembl:ENSG00000167333 euGenes: HUgn55128
    ECgene: TRIM68 H-InvDB: TRIM68

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM68 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM68 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM68 gene:
    Search GeneIP for patents involving TRIM68

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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