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Aliases for TRIM67 Gene

Aliases for TRIM67 Gene

  • Tripartite Motif Containing 67 2 3 5
  • TNL 3 4
  • Tripartite Motif-Containing 67 2
  • TRIM9-Like Protein TNL 3
  • TRIM9-Like Protein 4

External Ids for TRIM67 Gene

Previous GeneCards Identifiers for TRIM67 Gene

  • GC01P227606
  • GC01P229365
  • GC01P231298
  • GC01P201782

Summaries for TRIM67 Gene

GeneCards Summary for TRIM67 Gene

TRIM67 (Tripartite Motif Containing 67) is a Protein Coding gene. An important paralog of this gene is MID1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM67 Gene

Genomics for TRIM67 Gene

Regulatory Elements for TRIM67 Gene

Genomic Location for TRIM67 Gene

Chromosome:
1
Start:
231,162,112 bp from pter
End:
231,221,568 bp from pter
Size:
59,457 bases
Orientation:
Plus strand

Genomic View for TRIM67 Gene

Genes around TRIM67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM67 Gene

Proteins for TRIM67 Gene

  • Protein details for TRIM67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZTA4-TRI67_HUMAN
    Recommended name:
    Tripartite motif-containing protein 67
    Protein Accession:
    Q6ZTA4
    Secondary Accessions:
    • Q5TER7
    • Q5TER8
    • Q7Z4K7

    Protein attributes for TRIM67 Gene

    Size:
    783 amino acids
    Molecular mass:
    83823 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM67 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM67 Gene

Proteomics data for TRIM67 Gene at MOPED

Post-translational modifications for TRIM67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM67 Gene

No data available for DME Specific Peptides for TRIM67 Gene

Domains & Families for TRIM67 Gene

Suggested Antigen Peptide Sequences for TRIM67 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZTA4

UniProtKB/Swiss-Prot:

TRI67_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM67: view

Function for TRIM67 Gene

Gene Ontology (GO) - Molecular Function for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM67: view

Phenotypes for TRIM67 Gene

genes like me logo Genes that share phenotypes with TRIM67: view

Animal Model Products

miRNA for TRIM67 Gene

miRTarBase miRNAs that target TRIM67

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM67 Gene

Localization for TRIM67 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM67 Gene

Cytoplasm. Cytoplasm, cytoskeleton. Note=Microtubule-associated. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM67 Gene COMPARTMENTS Subcellular localization image for TRIM67 gene
Compartment Confidence
cytoskeleton 4
nucleus 4
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIM67: view

Pathways & Interactions for TRIM67 Gene

SuperPathways for TRIM67 Gene

No Data Available

Interacting Proteins for TRIM67 Gene

Gene Ontology (GO) - Biological Process for TRIM67 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046580 negative regulation of Ras protein signal transduction IEA --
genes like me logo Genes that share ontologies with TRIM67: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM67 Gene

Drugs & Compounds for TRIM67 Gene

No Compound Related Data Available

Transcripts for TRIM67 Gene

Unigene Clusters for TRIM67 Gene

Tripartite motif containing 67:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM67 Gene

No ASD Table

Relevant External Links for TRIM67 Gene

GeneLoc Exon Structure for
TRIM67
ECgene alternative splicing isoforms for
TRIM67

Expression for TRIM67 Gene

mRNA expression in normal human tissues for TRIM67 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM67 Gene

This gene is overexpressed in Brain - Cerebellum (x15.3) and Brain - Cerebellar Hemisphere (x14.7).

Protein differential expression in normal tissues from HIPED for TRIM67 Gene

This gene is overexpressed in Fetal Brain (62.0) and Retina (6.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM67 Gene



SOURCE GeneReport for Unigene cluster for TRIM67 Gene Hs.655089

genes like me logo Genes that share expression patterns with TRIM67: view

Protein tissue co-expression partners for TRIM67 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM67 Gene

Orthologs for TRIM67 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM67 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM67 35
  • 90.49 (n)
  • 95.14 (a)
TRIM67 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM67 35
  • 90.21 (n)
  • 95.77 (a)
TRIM67 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim67 35
  • 86.41 (n)
  • 92.71 (a)
Trim67 16
Trim67 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM67 35
  • 99.19 (n)
  • 99.49 (a)
TRIM67 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim67 35
  • 86.54 (n)
  • 92.34 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM67 36
  • 90 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM67 36
  • 89 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM67 35
  • 79.22 (n)
  • 88.98 (a)
TRIM67 36
  • 90 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM67 36
  • 83 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim67 35
  • 72 (n)
  • 81.74 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100332164 35
  • 73.61 (n)
  • 76.81 (a)
TRIM67 36
  • 75 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Trim9 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToMany
Species with no ortholog for TRIM67:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM67 Gene

ENSEMBL:
Gene Tree for TRIM67 (if available)
TreeFam:
Gene Tree for TRIM67 (if available)

Paralogs for TRIM67 Gene

(5) SIMAP similar genes for TRIM67 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM67: view

Variants for TRIM67 Gene

Sequence variations from dbSNP and Humsavar for TRIM67 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs566106 -- 231,220,813(-) GCCTT(C/T)CCCAG utr-variant-3-prime
rs530363 -- 231,220,173(-) TGGAA(A/C/G)GCCCC utr-variant-3-prime
rs524331 -- 231,219,324(-) AGATA(C/T)CTAGC utr-variant-3-prime
rs1022642 -- 231,180,158(+) GAGTT(C/T)ATCCT intron-variant
rs1055422 -- 231,166,406(+) TGTTG(A/G)TCTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM67 Gene

Variant ID Type Subtype PubMed ID
esv2494270 CNV Deletion 19546169
esv1972788 CNV Deletion 18987734
esv2724839 CNV Deletion 23290073
esv2678520 CNV Deletion 23128226
esv7591 CNV Loss 19470904
nsv517116 CNV Loss 19592680
esv2669296 CNV Deletion 23128226
esv27426 CNV Loss 19812545
nsv818833 CNV Loss 17921354
dgv18n17 CNV Loss 16327808
esv2555185 CNV Insertion 19546169
nsv873292 CNV Gain 21882294
esv2182022 CNV Deletion 18987734
esv2724850 CNV Deletion 23290073

Variation tolerance for TRIM67 Gene

Residual Variation Intolerance Score: 34.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.34; 41.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM67 Gene

HapMap Linkage Disequilibrium report
TRIM67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM67 Gene

Disorders for TRIM67 Gene

Relevant External Links for TRIM67

Genetic Association Database (GAD)
TRIM67
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM67

No disorders were found for TRIM67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM67 Gene

Publications for TRIM67 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short K.M. … Cox T.C. (J. Biol. Chem. 2006) 3 4 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TRIM67 Gene

Sources for TRIM67 Gene

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