TRIM67 Gene
protein-coding GIFtS: 41
GCID: GC01P231298
|
|
tripartite motif containing 67(Previous name: tripartite motif-containing 67 )
| |
Aliases
for TRIM67 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 671 2 | | TNL1 2 3 | | Tripartite Motif-Containing 671 2 | | TRIM9-Like Protein TNL2 | | Tripartite Motif-Containing Protein 672 | | TRIM9-Like Protein3 |
Export aliases for TRIM67 gene to outside databasesPrevious GC identifers: GC01P227606 GC01P229365 GC01P201782 |
Summaries
for TRIM67 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM67 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM67 gene promoter:
AhR NF-kappaB2 NRSF form 1 NF-kappaB NF-kappaB1 NRSF form 2 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM67
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM67 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q42.2 Ensembl cytogenetic band: 1q42.2 HGNC cytogenetic band: 1q42.2TRIM67 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P231298: view genomic region
(about GC identifiers)
Start:
|
231,297,858 bp from pter |
End:
|
231,357,314 bp from pter |
Size:
|
59,457 bases |
Orientation:
|
plus strand |
|
Proteins
for TRIM67 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI67_HUMAN, Q6ZTA4 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 67 Size: 783 amino acids; 83823 Da
Subcellular location: Cytoplasm (By similarity). Cytoplasm, cytoskeleton (By similarity). Note=Microtubule-associated(By similarity)
Sequence caution: Sequence=BAC86689.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact;
Secondary accessions: Q5TER7 Q5TER8 Q7Z4K7Alternative splicing: 2 isoforms: Q6ZTA4-3 Q6ZTA4-2 (Gene prediction based on EST data)Explore the universe of human proteins at neXtProt for TRIM67: NX_Q6ZTA4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6ZTA4
TRIM67 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001004342.3
ENSEMBL proteins: ENSP00000412124 ENSP00000400163 ENSP00000355613 ENSP00000355612
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TRIM67 for ontologies About GeneDecksing
TRIM67 Antibody Products:
Assay Products for TRIM67: |
Protein
Domains /
Families
for TRIM67 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM67 for domains About GeneDecksing
5/11 InterPro domains/families (see all 11):Graphical View of Domain Structure for InterPro Entry Q6ZTA4ProtoNet protein and cluster: Q6ZTA4 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB003649 B-box
UniProtKB/Swiss-Prot: TRI67_HUMAN, Q6ZTA4Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 2 B box-type zinc fingersSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 COS domainSimilarity: Contains 1 fibronectin type-III domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM67 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM67 (NM_001004342) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM67 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM67 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM67 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM67 for ontologies About GeneDecksing
|
Pathways & Interactions
for TRIM67 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM67
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0010976 | positive regulation of neuron projection development |
IEA | -- | | GO:0046580 | negative regulation of Ras protein signal transduction |
IEA | -- | | GO:2000060 | positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process |
IEA | -- |
TRIM67 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM67 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM67
Search CenterWatch for drugs/clinical trials and news about TRIM67 / TRI67
|
Transcripts
for TRIM67 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM67 gene: NM_001004342.3 Unigene Cluster for TRIM67: Tripartite motif containing 67 Hs.655089 [show with all ESTs]Unigene Representative Sequence: NM_0010043424 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444294(uc009xfn.1) ENST00000449018 ENST00000366653 ENST00000366652
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM67 (NM_001004342) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM67 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM67 |
Additional cDNA sequence: AK055338.1 AK126782.1 AY253917.1 CR627464.1 4 DOTS entries: DT.101963015 DT.101958600 DT.70102642 DT.95106964 24/29 AceView cDNA sequences (see all 29): BM698270 Z40641 AW297595 AY253917 Z46076 D56203 BI918017 AA340344 F04781 CR627464 BI916399 AI424633 AK055338 BG913053 NM_001004342 AK126782 BG819567 BM667560 N36794 AU252630 AU252494 Z44872 BG396890 AA084071
GeneLoc Exon Structure
|
Expression
for TRIM67 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM67 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGAGGTGTTT
About this image
See TRIM67 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM67
SOURCE GeneReport for Unigene cluster: Hs.655089
SABiosciences Expression via Pathway-Focused PCR Array including TRIM67: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM67
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM67 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM67 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM67 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM67 |
Orthologs
for TRIM67 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRIM67 gene from 5/18 species (see all 18) About this table
ENSEMBL Gene Tree for TRIM67 (if available)
TreeFam Gene Tree for TRIM67 (if available) |
Paralogs
for TRIM67 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM67 gene
- TRIM132 FSD1L2 TRIM462 TRIM632 TRIM592 TRIM92 TRIM362 MID22
- MID12 TRIM552 TRIM542 FSD12
4 SIMAP similar genes for TRIM67 using alignment to 4 protein entries: TRI67_HUMAN (see all proteins):TRIM9 TRIM59 TRIM2 MID1
TRIM67 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM67 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM67 (231297858 - 231357314 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 18 variations for TRIM67
9 CNVs: 48271 97665 48273 66108 48272 84898 9914 74934 48274
9 Indels: 10659 60951 44525 10657 10658 74935 10660 97666 44526 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM67 |
|
Disorders
/ Diseases
for TRIM67 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRIM67 for disorders About MalaCards
TRIM67 for disorders About GeneDecksing
OMIM gene information: 610584
OMIM disorders: --
Export disorders for TRIM67 gene to outside databases
|
Publications
for TRIM67 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM67 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM67) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PubMed id 16434393)1, 2 Short K.M. and Cox T.C. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
|
External Searches for TRIM67 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM67 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM67 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM67 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM67 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM67 gene:
Search GeneIP for patents involving TRIM67
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM67 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM67 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM67 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM67 | | | OriGene Protein Over-expression Lysate for TRIM67 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM67 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM67 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM67 | | OriGene Custom Protein Services for TRIM67 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM67 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM67 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM67 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM67 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM67 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM67 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TRIM67 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TRIM67 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM67 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM67 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM67 |
|
|
|
|
