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Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3
  • Tripartite Motif-Containing 66 2 3
  • C11orf29 3 4
  • Transcriptional Intermediary Factor 1 Delta 3
  • Chromosome 11 Open Reading Frame 29 2
  • TIF1DELTA 3
  • KIAA0298 4
  • TIF1D 3

External Ids for TRIM66 Gene

Previous HGNC Symbols for TRIM66 Gene

  • C11orf29

Previous GeneCards Identifiers for TRIM66 Gene

  • GC11M008301

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is TRIM28.

UniProtKB/Swiss-Prot for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

Regulatory Elements for TRIM66 Gene

Genomic Location for TRIM66 Gene

Chromosome:
11
Start:
8,612,037 bp from pter
End:
8,682,703 bp from pter
Size:
70,667 bases
Orientation:
Minus strand

Genomic View for TRIM66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15016-TRI66_HUMAN
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    O15016
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    Size:
    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    SequenceCaution:
    • Sequence=BAA20758.2; Type=Frameshift; Positions=797; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM66 Gene

Proteomics data for TRIM66 Gene at MOPED

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM66 Gene

Domains & Families for TRIM66 Gene

Suggested Antigen Peptide Sequences for TRIM66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15016

UniProtKB/Swiss-Prot:

TRI66_HUMAN :
  • Contains 1 bromo domain.
  • Contains 2 B box-type zinc fingers.
Domain:
  • Contains 1 bromo domain.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TRIM66: view

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Gene Ontology (GO) - Molecular Function for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0042803 protein homodimerization activity --
genes like me logo Genes that share ontologies with TRIM66: view

Phenotypes for TRIM66 Gene

MGI mutant phenotypes for TRIM66:
inferred from 1 alleles
GenomeRNAi human phenotypes for TRIM66:
genes like me logo Genes that share phenotypes with TRIM66: view

miRNA for TRIM66 Gene

miRTarBase miRNAs that target TRIM66

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM66

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM66 Gene COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0010369 chromocenter --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways & Interactions for TRIM66 Gene

SuperPathways for TRIM66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TRIM66: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM66 Gene

Drugs & Compounds for TRIM66 Gene

No Compound Related Data Available

Transcripts for TRIM66 Gene

Unigene Clusters for TRIM66 Gene

Tripartite motif containing 66:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM66

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
TRIM66
ECgene alternative splicing isoforms for
TRIM66

Expression for TRIM66 Gene

mRNA expression in normal human tissues for TRIM66 Gene

Protein differential expression in normal tissues from HIPED for TRIM66 Gene

This gene is overexpressed in Adipocyte (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TRIM66 Gene



SOURCE GeneReport for Unigene cluster for TRIM66 Gene Hs.130836

genes like me logo Genes that share expression patterns with TRIM66: view

Protein tissue co-expression partners for TRIM66 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM66 Gene

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM66 35
  • 89.27 (n)
  • 88.75 (a)
TRIM66 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM66 35
  • 89.13 (n)
  • 87.72 (a)
TRIM66 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim66 35
  • 86.44 (n)
  • 86.91 (a)
Trim66 16
Trim66 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM66 35
  • 99.49 (n)
  • 99.14 (a)
rat
(Rattus norvegicus)
Mammalia Trim66 35
  • 85.73 (n)
  • 86.01 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM66 36
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM66 36
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM66 35
  • 63.07 (n)
  • 57.36 (a)
TRIM66 36
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM66 36
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim66 35
  • 58.99 (n)
  • 53.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 35
zebrafish
(Danio rerio)
Actinopterygii trim66 36
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 36
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 36
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 36
  • 14 (a)
OneToMany
Species with no ortholog for TRIM66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM66 Gene

ENSEMBL:
Gene Tree for TRIM66 (if available)
TreeFam:
Gene Tree for TRIM66 (if available)

Paralogs for TRIM66 Gene

Paralogs for TRIM66 Gene

(2) SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations from dbSNP and Humsavar for TRIM66 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs885114 -- 8,657,209(+) AGTGA(A/G)GACAC intron-variant
rs1128559 -- 8,615,644(-) CTTTA(C/G)ACACC utr-variant-3-prime
rs1875568 -- 8,678,620(+) CTGAG(C/T)TTTTC intron-variant
rs2036423 -- 8,677,678(+) TTAAT(C/T)TTATC intron-variant
rs3942866 -- 8,676,781(+) AAGAG(C/T)GTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2751035 CNV Loss 17911159
nsv896983 CNV Loss 21882294

Variation tolerance for TRIM66 Gene

Gene Damage Index Score: 14.12; 96.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM66 Gene

HapMap Linkage Disequilibrium report
TRIM66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM66 Gene

Disorders for TRIM66 Gene

Relevant External Links for TRIM66

Genetic Association Database (GAD)
TRIM66
Human Genome Epidemiology (HuGE) Navigator
TRIM66
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM66
genes like me logo Genes that share disorders with TRIM66: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM66 Gene

Publications for TRIM66 Gene

  1. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K. … Losson R. (J. Biol. Chem. 2004) 23 67
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 67
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 67
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 67
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 67

Products for TRIM66 Gene

Sources for TRIM66 Gene

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