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Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3 5
  • Tripartite Motif-Containing 66 2 3
  • C11orf29 3 4
  • Transcriptional Intermediary Factor 1 Delta 3
  • Chromosome 11 Open Reading Frame 29 2
  • KIAA0298 4
  • TIF1D 3

External Ids for TRIM66 Gene

Previous HGNC Symbols for TRIM66 Gene

  • C11orf29

Previous GeneCards Identifiers for TRIM66 Gene

  • GC11M008301

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is TRIM28.

UniProtKB/Swiss-Prot for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

Regulatory Elements for TRIM66 Gene

Enhancers for TRIM66 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM66 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM66 Gene

8,612,037 bp from pter
8,682,703 bp from pter
70,667 bases
Minus strand

Genomic View for TRIM66 Gene

Genes around TRIM66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    • Sequence=BAA20758.2; Type=Frameshift; Positions=797; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM66 Gene


neXtProt entry for TRIM66 Gene

Proteomics data for TRIM66 Gene at MOPED

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM66 Gene

Domains & Families for TRIM66 Gene

Gene Families for TRIM66 Gene

Suggested Antigen Peptide Sequences for TRIM66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 bromo domain.
  • Contains 2 B box-type zinc fingers.
  • Contains 1 bromo domain.
  • Contains 2 B box-type zinc fingers.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TRIM66: view

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Phenotypes for TRIM66 Gene

genes like me logo Genes that share phenotypes with TRIM66: view

Animal Models for TRIM66 Gene

MGI Knock Outs for TRIM66:

Animal Model Products

miRNA for TRIM66 Gene

miRTarBase miRNAs that target TRIM66

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TRIM66 Gene COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways & Interactions for TRIM66 Gene

SuperPathways for TRIM66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM66 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM66 Gene

Drugs & Compounds for TRIM66 Gene

No Compound Related Data Available

Transcripts for TRIM66 Gene

Unigene Clusters for TRIM66 Gene

Tripartite motif containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM66 Gene

mRNA expression in normal human tissues for TRIM66 Gene

Protein differential expression in normal tissues from HIPED for TRIM66 Gene

This gene is overexpressed in Adipocyte (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM66 Gene

SOURCE GeneReport for Unigene cluster for TRIM66 Gene Hs.130836

genes like me logo Genes that share expression patterns with TRIM66: view

Protein tissue co-expression partners for TRIM66 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM66 Gene

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM66 35
  • 89.27 (n)
  • 88.75 (a)
TRIM66 36
  • 87 (a)
(Canis familiaris)
Mammalia TRIM66 35
  • 89.13 (n)
  • 87.72 (a)
TRIM66 36
  • 79 (a)
(Mus musculus)
Mammalia Trim66 35
  • 86.44 (n)
  • 86.91 (a)
Trim66 16
Trim66 36
  • 80 (a)
(Pan troglodytes)
Mammalia TRIM66 35
  • 99.49 (n)
  • 99.14 (a)
(Rattus norvegicus)
Mammalia Trim66 35
  • 85.73 (n)
  • 86.01 (a)
(Monodelphis domestica)
Mammalia TRIM66 36
  • 63 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM66 36
  • 51 (a)
(Gallus gallus)
Aves TRIM66 35
  • 63.07 (n)
  • 57.36 (a)
TRIM66 36
  • 49 (a)
(Anolis carolinensis)
Reptilia TRIM66 36
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim66 35
  • 58.99 (n)
  • 53.18 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 35
(Danio rerio)
Actinopterygii trim66 36
  • 30 (a)
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 36
  • 12 (a)
(Caenorhabditis elegans)
Secernentea nhl-2 36
  • 11 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 36
  • 14 (a)
Species with no ortholog for TRIM66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM66 Gene

Gene Tree for TRIM66 (if available)
Gene Tree for TRIM66 (if available)

Paralogs for TRIM66 Gene

Paralogs for TRIM66 Gene

(2) SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations from dbSNP and Humsavar for TRIM66 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs885114 -- 8,657,209(+) AGTGA(A/G)GACAC intron-variant
rs1128559 -- 8,615,644(-) CTTTA(C/G)ACACC utr-variant-3-prime
rs1875568 -- 8,678,620(+) CTGAG(C/T)TTTTC intron-variant
rs2036423 -- 8,677,678(+) TTAAT(C/T)TTATC intron-variant
rs7114215 -- 8,670,019(+) tttat(A/T)ttttt intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2751035 CNV Loss 17911159
nsv896983 CNV Loss 21882294

Variation tolerance for TRIM66 Gene

Gene Damage Index Score: 14.12; 96.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM66 Gene

Disorders for TRIM66 Gene

Relevant External Links for TRIM66

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM66 Gene

Publications for TRIM66 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 67
  2. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K. … Losson R. (J. Biol. Chem. 2004) 3 23
  3. Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche. (PMID: 25231870) Perry J.R. … Ong K.K. (Nature 2014) 3
  4. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3

Products for TRIM66 Gene

Sources for TRIM66 Gene