Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3
  • Tripartite Motif-Containing 66 2 3
  • C11orf29 3 4
  • KIAA0298 4 6
  • TIF1D 3 6
  • Transcriptional Intermediary Factor 1 Delta 3
  • Tripartite Motif-Containing Protein 66 3
  • Chromosome 11 Open Reading Frame 29 2
  • TIF1DELTA 3

External Ids for TRIM66 Gene

Previous Symbols for TRIM66 Gene

  • C11orf29

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. An important paralog of this gene is TRIM28.

UniProtKB/Swiss-Prot for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

Genomic Location for TRIM66 Gene

Start:
8,612,037 bp from pter
End:
8,679,939 bp from pter
Size:
67,903 bases
Orientation:
Minus strand

Genomic View for TRIM66 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Regulatory Elements for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15016-TRI66_HUMAN
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    O15016
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    Size:
    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    SequenceCaution:
    • Sequence=BAA20758.2; Type=Frameshift; Positions=797; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM66 Gene

Proteomics data for TRIM66 Gene at MOPED

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM66 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM66 Gene

Domains for TRIM66 Gene

Gene Families for TRIM66 Gene

HGNC:
  • TRIM :Tripartite motif containing / Tripartite motif containing
  • PHF :Zinc fingers, PHD-type

UniProtKB/Swiss-Prot:

TRI66_HUMAN
Domain:
  • Contains 1 bromo domain.:
    • O15016
Similarity:
  • Contains 2 B box-type zinc fingers.:
    • O15016
  • Contains 1 PHD-type zinc finger.:
    • O15016
genes like me logo Genes that share domains with TRIM66: view

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function: May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Gene Ontology (GO) - Molecular Function for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0042803 protein homodimerization activity --
genes like me logo Genes that share ontologies with TRIM66: view

Phenotypes for TRIM66 Gene

MGI mutant phenotypes for TRIM66:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with TRIM66: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM66 Gene COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0010369 chromocenter --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways for TRIM66 Gene

SuperPathways for TRIM66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045892 negative regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with TRIM66: view

No data available for Pathways by source for TRIM66 Gene

Transcripts for TRIM66 Gene

Unigene Clusters for TRIM66 Gene

Tripartite motif containing 66:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
TRIM66
ECgene alternative splicing isoforms for
TRIM66

Expression for TRIM66 Gene

mRNA expression in normal human tissues for TRIM66 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM66 Gene

SOURCE GeneReport for Unigene cluster for TRIM66 Gene Hs.130836

genes like me logo Genes that share expressions with TRIM66: view

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM66 36
  • 99.49 (n)
  • 99.14 (a)
cow
(Bos Taurus)
Mammalia TRIM66 36
  • 89.27 (n)
  • 88.75 (a)
TRIM66 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM66 36
  • 89.13 (n)
  • 87.72 (a)
TRIM66 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim66 36
  • 86.44 (n)
  • 86.91 (a)
Trim66 16
Trim66 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM66 37
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM66 37
  • 51 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim66 36
  • 85.73 (n)
  • 86.01 (a)
chicken
(Gallus gallus)
Aves TRIM66 36
  • 63.07 (n)
  • 57.36 (a)
TRIM66 37
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM66 37
  • 52 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 36
tropical clawed frog
(Silurana tropicalis)
Amphibia trim66 36
  • 58.99 (n)
  • 53.18 (a)
zebrafish
(Danio rerio)
Actinopterygii trim66 37
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 37
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 37
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 37
  • 14 (a)
OneToMany
Species with no ortholog for TRIM66:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM66 Gene

ENSEMBL:
Gene Tree for TRIM66 (if available)
TreeFam:
Gene Tree for TRIM66 (if available)

Paralogs for TRIM66 Gene

Paralogs for TRIM66 Gene

Selected SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations from dbSNP and Humsavar for TRIM66 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs885114 -- 8,657,209(+) AGTGA(A/G)GACAC intron-variant
rs1128559 -- 8,615,644(-) CTTTA(C/G)ACACC utr-variant-3-prime
rs1502316 -- 8,662,504(-) AGCCC(A/G)ATGCT intron-variant
rs1502317 -- 8,660,471(-) AGTCT(A/G)TGGTT upstream-variant-2KB, intron-variant
rs1875568 -- 8,678,620(+) CTGAG(C/T)TTTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
nsv7215 OTHER Inversion 18451855
nsv499766 OTHER Inversion 21111241
esv2751035 CNV Loss 17911159
nsv896983 CNV Loss 21882294

Relevant External Links for TRIM66 Gene

HapMap Linkage Disequilibrium report
TRIM66

Disorders for TRIM66 Gene

Relevant External Links for TRIM66

Genetic Association Database (GAD)
TRIM66
Human Genome Epidemiology (HuGE) Navigator
TRIM66
genes like me logo Genes that share disorders with TRIM66: view

No data available for UniProtKB/Swiss-Prot for TRIM66 Gene

Publications for TRIM66 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4
  2. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 3 4
  3. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 49
  4. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K. … Losson R. (J. Biol. Chem. 2004) 3 23
  5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PMID: 23563607) Berndt S.I. … Ingelsson E. (Nat. Genet. 2013) 3

Products for TRIM66 Gene

Sources for TRIM66 Gene

Back to Top

Content