TRIM66 Gene
protein-coding GIFtS: 46
GCID: GC11M008595
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tripartite motif containing 66(Previous names: chromosome 11 open reading frame 29, tripartite motif-containing...)
(Previous symbol: C11orf29)
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Aliases
for TRIM66 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 661 2 | | Chromosome 11 Open Reading Frame 291 | | C11orf291 2 3 | | TIF1DELTA2 | | TIF1D1 2 5 | | Transcriptional Intermediary Factor 1 Delta2 | | KIAA02981 3 5 | | Tripartite Motif-Containing Protein 662 | | Tripartite Motif-Containing 661 2 | | |
Export aliases for TRIM66 gene to outside databasesPrevious GC identifer: GC11M008301 |
Summaries
for TRIM66 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TRI66_HUMAN, O15016Function: May function as transcription repressor; The repressive effects are mediated, at least in part, byrecruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3complex formation and centromere association (By similarity)
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Genomic Views
for TRIM66 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM66 gene promoter:
STAT5A AP-4 LUN-1 GATA-1 FOXL1 MZF-1 E2F-1 E2F Msx-1 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM66
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM66 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4TRIM66 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M008595: view genomic region
(about GC identifiers)
Start:
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8,633,584 bp from pter |
End:
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8,693,413 bp from pter |
Size:
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59,830 bases |
Orientation:
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minus strand |
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Proteins
for TRIM66 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI66_HUMAN, O15016 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 66 Size: 1216 amino acids; 134663 Da
Subunit: Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity)
Subcellular location: Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm(By similarity)
Sequence caution: Sequence=BAA20758.2; Type=Frameshift; Positions=797;
Secondary accessions: Q9BQQ4Alternative splicing: 2 isoforms: O15016-1 O15016-2 Explore the universe of human proteins at neXtProt for TRIM66: NX_O15016
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O15016
TRIM66 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055633.1
ENSEMBL proteins: ENSP00000384876 ENSP00000437234 ENSP00000299550
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TRIM66 for ontologies About GeneDecksing
TRIM66 Antibody Products:
Assay Products for TRIM66: |
Protein
Domains /
Families
for TRIM66 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM66 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry O15016ProtoNet protein and cluster: O15016 4 Blocks protein families: IPB000315 B-box zinc finger signature IPB001487 Bromodomain signature IPB001965 Zn-finger-like IPB003649 B-box
UniProtKB/Swiss-Prot: TRI66_HUMAN, O15016Similarity: Contains 2 B box-type zinc fingersSimilarity: Contains 1 bromo domainSimilarity: Contains 1 PHD-type zinc finger |
Function
for TRIM66 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TRI66_HUMAN, O15016Function: May function as transcription repressor; The repressive effects are mediated, at least in part, byrecruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3complex formation and centromere association (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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| |  | GenScript: all cDNA clones in your preferred vector: TRIM66 (NM_014818) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM66 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM66 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM66 |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005515 | protein binding |
-- | -- | | GO:0008270 | zinc ion binding |
IEA | -- | | GO:0042803 | protein homodimerization activity |
-- | -- |
TRIM66 for ontologies About GeneDecksing
Animal Models:
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Trim66):
TRIM66 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TRIM66 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM66
STRING Interaction
Network Preview (showing 3 interactants - click image to see more details)
3 Interacting proteins for TRIM66 (O150163 ENSP000002995504) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045892 | negative regulation of transcription, DNA-dependent |
-- | -- |
TRIM66 for ontologies About GeneDecksing
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Drugs & Compounds
for TRIM66 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM66
Search CenterWatch for drugs/clinical trials and news about TRIM66 / TRI66
|
Transcripts
for TRIM66 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM66 gene: NM_014818.1 Unigene Cluster for TRIM66: Tripartite motif containing 66 Hs.130836 [show with all ESTs]Unigene Representative Sequence: NM_0148188 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000402157 ENST00000481014 ENST00000529211 ENST00000525788 ENST00000530502
ENST00000531498(uc009yfq.3) ENST00000529057 ENST00000299550(uc010rbo.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM66 (NM_014818) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM66 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM66 |
Additional cDNA sequence: AK000908.1 AK307240.1 AK308310.1 BC031354.1 8 DOTS entries: DT.443203 DT.206912 DT.75100692 DT.120725985 DT.120683384 DT.40292791 DT.95124270 DT.120683380 24/82 AceView cDNA sequences (see all 82): BC031354 BX116665 BF436622 AI347789 AA632341 AA759118 AB002296 CD107202 AU133532 AI537517 AK000908 AA465716 AI831043 AU117317 BG682280 AA286734 AI286048 BG570211 BG654805 BU152921 AL079535 BQ448518 BQ372964 AW663213
GeneLoc Exon Structure
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Expression
for TRIM66 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM66 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AGGGAGGATA
About this image
See TRIM66 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM66
SOURCE GeneReport for Unigene cluster: Hs.130836
SABiosciences Custom PCR Arrays for TRIM66
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM66
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM66 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM66 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM66 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM66 |
Orthologs
for TRIM66 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TRIM66 gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for TRIM66 (if available)
TreeFam Gene Tree for TRIM66 (if available) |
Paralogs
for TRIM66 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM66 gene
- TRIM332 TRIM242 TRIM282
3 SIMAP similar genes for TRIM66 using alignment to 3 protein entries: TRI66_HUMAN (see all proteins):AIRE SP110 FLJ00340
TRIM66 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM66 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM66 (8633584 - 8693413 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRIM66
1 CNV: 9175 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM66 |
|
Disorders
/ Diseases
for TRIM66 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRIM66 for disorders About MalaCards
TRIM66 for disorders About GeneDecksing
OMIM gene information: 612000
OMIM disorders: --
Human Genome Epidemiology (HuGE) Navigator: TRIM66 (2 documents)
Export disorders for TRIM66 gene to outside databases
|
Publications
for TRIM66 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM66 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM66) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2, 3 Nagase T.... Ohara O. (1997)
- Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PubMed id 11528127)1, 2 Amid C.... Schmidt E.R. (2001)
- TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PubMed id 15322135)1, 9 Khetchoumian K....Losson R. (2004)
- Thirty new loci for age at menarche identified by a m eta-analysis of genome-wide association studies. (PubMed id 21102462)1 Elks C.E....Murray A. (2010)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (2006)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)2 Taylor T.D....Sakaki Y. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for TRIM66 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIM66 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM66 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TRIM66 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM66 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TRIM66 gene:
Search GeneIP for patents involving TRIM66
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM66 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM66 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM66 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM66 | | | OriGene Protein Over-expression Lysate for TRIM66 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM66 | | OriGene 3'-UTR Clone for TRIM66 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM66 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM66 | | OriGene Custom Protein Services for TRIM66 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM66 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM66 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM66 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM66 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM66 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM66 |
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| | | | Search Tocris compounds for TRIM66 |
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 | | | TRIM66 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM66 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM66 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM66 |
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