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Aliases for TRIM66 Gene

Aliases for TRIM66 Gene

  • Tripartite Motif Containing 66 2 3 5
  • C11orf29 3 4
  • Transcriptional Intermediary Factor 1 Delta 3
  • Tripartite Motif-Containing Protein 66 3
  • Chromosome 11 Open Reading Frame 29 2
  • Tripartite Motif-Containing 66 2
  • TIF1DELTA 3
  • KIAA0298 4
  • TIF1D 3

External Ids for TRIM66 Gene

Previous HGNC Symbols for TRIM66 Gene

  • C11orf29

Previous GeneCards Identifiers for TRIM66 Gene

  • GC11M008301

Summaries for TRIM66 Gene

GeneCards Summary for TRIM66 Gene

TRIM66 (Tripartite Motif Containing 66) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity and chromatin binding. An important paralog of this gene is TRIM33.

UniProtKB/Swiss-Prot for TRIM66 Gene

  • May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM66 Gene

Genomics for TRIM66 Gene

Regulatory Elements for TRIM66 Gene

Enhancers for TRIM66 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F008681 0.2 ENCODE 49.7 -3.2 -3153 8.7 HDGF PKNOX1 ARNT CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 TRIM66 EIF3F ENSG00000254397 TMEM9B-AS1 SNORA3B STK33 ZNF143 RPL27A WEE1 RPL21P97
GH11F008697 0.8 Ensembl ENCODE 45.2 -17.1 -17090 4.1 ATF1 PKNOX1 SIN3A FOS ZNF263 SP5 NFYC PPARG CREB3 SMARCA4 TRIM66 WEE1 STK33 EIF3F ZNF143 TMEM9B ENSG00000254665 PIR56836
GH11F008713 1.1 Ensembl ENCODE 36.5 -36.2 -36160 10.4 PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF48 YY1 ZNF121 FOS TRIM66 AKIP1 ENSG00000254665 RPL27A ENSG00000255159 ST5 SNORA3A SNORA3B ENSG00000254900 TMEM9B
GH11F008701 0.6 FANTOM5 23.8 -19.3 -19337 0.1 HLF TRIM66 STK33 ENSG00000254665 PIR56836
GH11F008707 1 Ensembl ENCODE 22 -26.3 -26327 4.6 ATF1 PKNOX1 SIN3A RAD21 YY1 ETV6 FOS ZNF680 CEBPB REST TRIM66 SNORA3A SNORA3B RPL27A ENSG00000254900 ENSG00000254665 PIR56836
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM66 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM66 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000684794 -297 2801 HDGF PKNOX1 CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF207

Genomic Location for TRIM66 Gene

Chromosome:
11
Start:
8,612,037 bp from pter
End:
8,682,703 bp from pter
Size:
70,667 bases
Orientation:
Minus strand

Genomic View for TRIM66 Gene

Genes around TRIM66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM66 Gene

Proteins for TRIM66 Gene

  • Protein details for TRIM66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15016-TRI66_HUMAN
    Recommended name:
    Tripartite motif-containing protein 66
    Protein Accession:
    O15016
    Secondary Accessions:
    • Q9BQQ4

    Protein attributes for TRIM66 Gene

    Size:
    1216 amino acids
    Molecular mass:
    134663 Da
    Quaternary structure:
    • Can form homodimers and heterodimers. Interacts with CBX5, CBX1 and CBX3 via PxVxL motif (By similarity).
    SequenceCaution:
    • Sequence=BAA20758.2; Type=Frameshift; Positions=797; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM66 Gene

Post-translational modifications for TRIM66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for TRIM66
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRIM66

No data available for DME Specific Peptides for TRIM66 Gene

Domains & Families for TRIM66 Gene

Gene Families for TRIM66 Gene

Suggested Antigen Peptide Sequences for TRIM66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15016

UniProtKB/Swiss-Prot:

TRI66_HUMAN :
  • Contains 1 bromo domain.
  • Contains 2 B box-type zinc fingers.
Domain:
  • Contains 1 bromo domain.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 PHD-type zinc finger.
genes like me logo Genes that share domains with TRIM66: view

Function for TRIM66 Gene

Molecular function for TRIM66 Gene

UniProtKB/Swiss-Prot Function:
May function as transcription repressor; The repressive effects are mediated, at least in part, by recruitment of deacetylase activity. May play a role as negative regulator of postmeiotic genes acting through CBX3 complex formation and centromere association (By similarity).

Gene Ontology (GO) - Molecular Function for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM66: view
genes like me logo Genes that share phenotypes with TRIM66: view

Animal Models for TRIM66 Gene

MGI Knock Outs for TRIM66:

Animal Model Products

miRNA for TRIM66 Gene

miRTarBase miRNAs that target TRIM66

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM66 Gene

Localization for TRIM66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM66 Gene

Nucleus. Note=Forms discrete foci within the centromeric chromocenter and surrounding nucleoplasm. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM66 Gene COMPARTMENTS Subcellular localization image for TRIM66 gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with TRIM66: view

Pathways & Interactions for TRIM66 Gene

SuperPathways for TRIM66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM66 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM66 Gene

Transcripts for TRIM66 Gene

Unigene Clusters for TRIM66 Gene

Tripartite motif containing 66:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM66 Gene

No ASD Table

Relevant External Links for TRIM66 Gene

GeneLoc Exon Structure for
TRIM66
ECgene alternative splicing isoforms for
TRIM66

Expression for TRIM66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM66 Gene

Protein differential expression in normal tissues from HIPED for TRIM66 Gene

This gene is overexpressed in Adipocyte (61.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM66 Gene



Protein tissue co-expression partners for TRIM66 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM66 Gene:

TRIM66

SOURCE GeneReport for Unigene cluster for TRIM66 Gene:

Hs.130836
genes like me logo Genes that share expression patterns with TRIM66: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM66 Gene

Orthologs for TRIM66 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM66 34
  • 99.49 (n)
cow
(Bos Taurus)
Mammalia TRIM66 34 35
  • 89.27 (n)
dog
(Canis familiaris)
Mammalia TRIM66 34 35
  • 89.13 (n)
mouse
(Mus musculus)
Mammalia Trim66 34 16 35
  • 86.44 (n)
rat
(Rattus norvegicus)
Mammalia Trim66 34
  • 85.73 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM66 35
  • 63 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM66 35
  • 51 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM66 34 35
  • 63.07 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM66 35
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim66 34
  • 58.99 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.24102 34
zebrafish
(Danio rerio)
Actinopterygii trim66 35
  • 30 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta mei-P26 35
  • 12 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-2 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9380 35
  • 14 (a)
OneToMany
Species where no ortholog for TRIM66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TRIM66 Gene

ENSEMBL:
Gene Tree for TRIM66 (if available)
TreeFam:
Gene Tree for TRIM66 (if available)

Paralogs for TRIM66 Gene

Paralogs for TRIM66 Gene

(2) SIMAP similar genes for TRIM66 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM66: view

Variants for TRIM66 Gene

Sequence variations from dbSNP and Humsavar for TRIM66 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs10128597 -- 8,673,283(+) TTCAT(A/G)AGTTC intron-variant, upstream-variant-2KB
rs10160373 -- 8,623,963(+) TTACC(C/T)GGGAT intron-variant
rs10533257 -- 8,623,019(+) TTCAT(A/T)CATAG intron-variant
rs10591325 -- 8,646,942(+) ATACT(-/GCCTC)AGTAG intron-variant
rs10604996 -- 8,647,446(+) GAAAG(-/AA)TGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM66 Gene

Variant ID Type Subtype PubMed ID
esv2751035 CNV loss 17911159
nsv499766 OTHER inversion 21111241
nsv7215 OTHER inversion 18451855

Variation tolerance for TRIM66 Gene

Gene Damage Index Score: 14.12; 96.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM66 Gene

Disorders for TRIM66 Gene

Relevant External Links for TRIM66

Genetic Association Database (GAD)
TRIM66
Human Genome Epidemiology (HuGE) Navigator
TRIM66
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM66

No disorders were found for TRIM66 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM66 Gene

Publications for TRIM66 Gene

  1. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 2 3 4 64
  2. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 46 64
  3. TIF1delta, a novel HP1-interacting member of the transcriptional intermediary factor 1 (TIF1) family expressed by elongating spermatids. (PMID: 15322135) Khetchoumian K. … Losson R. (J. Biol. Chem. 2004) 3 22 64
  4. Comparative genomic sequencing reveals a strikingly similar architecture of a conserved syntenic region on human chromosome 11p15.3 (including gene ST5) and mouse chromosome 7. (PMID: 11528127) Amid C. … Schmidt E.R. (Cytogenet. Cell Genet. 2001) 3 4 64
  5. TRIM66 overexpresssion contributes to osteosarcoma carcinogenesis and indicates poor survival outcome. (PMID: 26247633) Chen Y. … Chen D. (Oncotarget 2015) 3 64

Products for TRIM66 Gene

Sources for TRIM66 Gene

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