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Aliases for TRIM65 Gene

Aliases for TRIM65 Gene

  • Tripartite Motif Containing 65 2 3 5
  • Tripartite Motif-Containing 65 2
  • 4732463G12Rik 3

External Ids for TRIM65 Gene

Previous GeneCards Identifiers for TRIM65 Gene

  • GC17M071397
  • GC17M073885
  • GC17M069310

Summaries for TRIM65 Gene

GeneCards Summary for TRIM65 Gene

TRIM65 (Tripartite Motif Containing 65) is a Protein Coding gene. An important paralog of this gene is TRIM16L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM65 Gene

Genomics for TRIM65 Gene

Regulatory Elements for TRIM65 Gene

Promoters for TRIM65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM65 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM65 Gene

75,880,335 bp from pter
75,897,003 bp from pter
16,669 bases
Minus strand

Genomic View for TRIM65 Gene

Genes around TRIM65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM65 Gene

Proteins for TRIM65 Gene

  • Protein details for TRIM65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 65
    Protein Accession:
    Secondary Accessions:
    • Q4G0F0
    • Q6DKJ6
    • Q9BRP6

    Protein attributes for TRIM65 Gene

    517 amino acids
    Molecular mass:
    57353 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH73831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TRIM65 Gene

Proteomics data for TRIM65 Gene at MOPED

Post-translational modifications for TRIM65 Gene

  • Ubiquitination at Lys 206
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM65 Gene

No data available for DME Specific Peptides for TRIM65 Gene

Domains & Families for TRIM65 Gene

Gene Families for TRIM65 Gene

Suggested Antigen Peptide Sequences for TRIM65 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM65: view

Function for TRIM65 Gene

Gene Ontology (GO) - Molecular Function for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM65: view
genes like me logo Genes that share phenotypes with TRIM65: view

Animal Models for TRIM65 Gene

MGI Knock Outs for TRIM65:

Animal Model Products

miRNA for TRIM65 Gene

miRTarBase miRNAs that target TRIM65

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM65 Gene

Localization for TRIM65 Gene

Subcellular locations from

Jensen Localization Image for TRIM65 Gene COMPARTMENTS Subcellular localization image for TRIM65 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM65 Gene

Pathways & Interactions for TRIM65 Gene

SuperPathways for TRIM65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM65 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM65 Gene

Drugs & Compounds for TRIM65 Gene

No Compound Related Data Available

Transcripts for TRIM65 Gene

Unigene Clusters for TRIM65 Gene

Tripartite motif containing 65:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM65 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -

Relevant External Links for TRIM65 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM65 Gene

mRNA expression in normal human tissues for TRIM65 Gene

Protein differential expression in normal tissues from HIPED for TRIM65 Gene

This gene is overexpressed in Serum (37.8) and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM65 Gene

SOURCE GeneReport for Unigene cluster for TRIM65 Gene Hs.189823

genes like me logo Genes that share expression patterns with TRIM65: view

Protein tissue co-expression partners for TRIM65 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM65 Gene

Orthologs for TRIM65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM65 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM65 35
  • 83.3 (n)
  • 76.73 (a)
TRIM65 36
  • 76 (a)
(Canis familiaris)
Mammalia TRIM65 35
  • 81.45 (n)
  • 75 (a)
TRIM65 36
  • 72 (a)
(Mus musculus)
Mammalia Trim65 35
  • 75.02 (n)
  • 64.66 (a)
Trim65 16
Trim65 36
  • 64 (a)
(Pan troglodytes)
Mammalia TRIM65 35
  • 99.18 (n)
  • 98.56 (a)
TRIM65 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim65 35
  • 73.57 (n)
  • 64.65 (a)
(Monodelphis domestica)
Mammalia TRIM65 36
  • 45 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM65 36
  • 23 (a)
(Gallus gallus)
Aves TRIM65 35
  • 55.1 (n)
  • 42.3 (a)
-- 36
  • 21 (a)
(Anolis carolinensis)
Reptilia TRIM65 36
  • 22 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim65 35
  • 45.26 (n)
  • 35.57 (a)
(Danio rerio)
Actinopterygii LOC100149099 35
  • 46.2 (n)
  • 34.23 (a)
trim65 36
  • 29 (a)
Species with no ortholog for TRIM65:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM65 Gene

Gene Tree for TRIM65 (if available)
Gene Tree for TRIM65 (if available)

Paralogs for TRIM65 Gene

Paralogs for TRIM65 Gene

(6) SIMAP similar genes for TRIM65 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRIM65: view

Variants for TRIM65 Gene

Sequence variations from dbSNP and Humsavar for TRIM65 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs34593741 - 75,891,243(+) GGGCC(C/T)GCCTG intron-variant, reference, missense, utr-variant-3-prime
rs9892938 - 75,891,237(+) GCTGC(C/T)GGGCC intron-variant, reference, missense, utr-variant-3-prime
rs7222757 - 75,892,346(+) AATGG(A/C)CCCGC nc-transcript-variant, reference, missense
rs3760128 - 75,890,807(+) GCCCC(A/G)GAGGG intron-variant, downstream-variant-500B, reference, missense
rs1551619 -- 75,889,724(+) TGTTC(C/T)CTGAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM65 Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
nsv908821 CNV Loss 21882294
nsv908822 CNV Loss 21882294
nsv908823 CNV Loss 21882294

Variation tolerance for TRIM65 Gene

Gene Damage Index Score: 8.02; 84.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM65 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM65 Gene

Disorders for TRIM65 Gene

Relevant External Links for TRIM65

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM65 Gene

Publications for TRIM65 Gene

  1. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. (PMID: 21681796) Fornage M. … Launer L.J. (Ann. Neurol. 2011) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. TRIM65 regulates microRNA activity by ubiquitination of TNRC6. (PMID: 24778252) Li S. … Dorf M.E. (Proc. Natl. Acad. Sci. U.S.A. 2014) 3
  5. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M. … Gstaiger M. (Cell Rep 2013) 3

Products for TRIM65 Gene

Sources for TRIM65 Gene

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