TRIM65 Gene
protein-coding GIFtS: 46
GCID: GC17M073885
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tripartite motif containing 65(Previous name: tripartite motif-containing 65 )
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Aliases
for TRIM65 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 651 2 | | Tripartite Motif-Containing 651 | | 4732463G12Rik2 | | Tripartite Motif-Containing Protein 652 |
Export aliases for TRIM65 gene to outside databasesPrevious GC identifers: GC17M071397 GC17M069310 |
Summaries
for TRIM65 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM65 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000017.10 NC_018928.1 NT_010783.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM65 gene promoter:
AhR ER-alpha AML1a Tal-1beta Egr-4 GATA-2 Egr-2 PPAR-alpha HOXA5 ITF-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM65
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM65 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 17q25.1 Ensembl cytogenetic band: 17q25.1 HGNC cytogenetic band: 17q25.1TRIM65 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 17 GeneLoc Exon Structure GeneLoc location for GC17M073885: view genomic region
(about GC identifiers)
Start:
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73,876,416 bp from pter |
End:
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73,893,084 bp from pter |
Size:
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16,669 bases |
Orientation:
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minus strand |
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Proteins
for TRIM65 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI65_HUMAN, Q6PJ69 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 65 Size: 517 amino acids; 57353 Da
Sequence caution: Sequence=AAH73831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q4G0F0 Q6DKJ6 Q9BRP6Explore the universe of human proteins at neXtProt for TRIM65: NX_Q6PJ69
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6PJ69
TRIM65 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001243053.1 NP_775818.2
ENSEMBL proteins: ENSP00000465034 ENSP00000466353 ENSP00000269383 ENSP00000441480 ENSP00000444607
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM65 for ontologies About GeneDecksing
TRIM65 Antibody Products:
Assay Products for TRIM65: |
Protein
Domains /
Families
for TRIM65 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM65 for domains About GeneDecksing
5/9 InterPro domains/families (see all 9):Graphical View of Domain Structure for InterPro Entry Q6PJ69ProtoNet protein and cluster: Q6PJ69 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TRI65_HUMAN, Q6PJ69Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM65 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM65 (NM_173547) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM65 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM65 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM65 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM65 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TRIM65:
|
Pathways & Interactions
for TRIM65 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM65
STRING Interaction
Network Preview (showing 5 interactants - click image to see 9)
5/9 Interacting proteins for TRIM65 (Q6PJ692, 3 ENSP000002693834) via UniProtKB, MINT, STRING, and/or I2D (see all 9)About this table
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Drugs & Compounds
for TRIM65 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM65
Search CenterWatch for drugs/clinical trials and news about TRIM65 / TRI65
|
Transcripts
for TRIM65 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM65 gene (2 alternative transcripts): NM_001256124.1 NM_173547.3 Unigene Cluster for TRIM65: Tripartite motif containing 65 Hs.189823 [show with all ESTs]Unigene Representative Sequence: NM_1735476 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000591668 ENST00000592642 ENST00000269383(uc002jpx.3) ENST00000543309
ENST00000540128 ENST00000540812
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM65 (NM_173547) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM65 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM65 |
Additional cDNA sequence: BC006138.1 BC013181.1 BC021259.2 BC073831.1 BC098412.1 7 DOTS entries: DT.40253464 DT.75100496 DT.102824235 DT.97831607 DT.121007868 DT.92070475 DT.91664380 24/99 AceView cDNA sequences (see all 99): BM914546 BU152538 AI242308 BG391892 BG749802 AI419584 BU627004 AI992214 BQ070146 BP432327 BF516410 BC006138 BQ917401 BQ920940 BQ221910 BM825243 AI205183 BE208418 BE206698 BC013181 BE019017 BG751862 F11562 BI856346
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM65 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c |
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| SP1: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRIM65
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Expression
for TRIM65 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM65 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATTTTGCTTG
About this image
See TRIM65 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM65
SOURCE GeneReport for Unigene cluster: Hs.189823
SABiosciences Custom PCR Arrays for TRIM65
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM65
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM65 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM65 |
Orthologs
for TRIM65 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM65 gene from 3/10 species (see all 10) About this table
ENSEMBL Gene Tree for TRIM65 (if available)
TreeFam Gene Tree for TRIM65 (if available) |
Paralogs
for TRIM65 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM65 gene
- TRIM252 TRIM292 TRIM16L2 TRIM472 TRIM162 TRIM82
6 SIMAP similar genes for TRIM65 using alignment to 7 protein entries: TRI65_HUMAN (see all proteins):TRIM39 TRIM17 TRIM3 TRIM41 TRIM60 TRIM5
TRIM65 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM65 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 17 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM65 (73876416 - 73893084 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TRIM65: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM65 |
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Disorders
/ Diseases
for TRIM65 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM65 for disorders About GeneDecksing
1  disease for TRIM65: About MalaCardscerebritis
Export disorders for TRIM65 gene to outside databases
|
Publications
for TRIM65 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM65 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TRIM65) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Genome-wide association studies of cerebral white mat ter lesion burden: the CHARGE consortium. (PubMed id 21681796)1 Fornage M....Launer L.J. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- A directed protein interaction network for investigat ing intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (2011)
- A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (2009)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
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External Searches for TRIM65 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIM65 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM65 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM65 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM65 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TRIM65 gene:
Search GeneIP for patents involving TRIM65
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM65 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM65 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM65 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM65 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM65 | | OriGene 3'-UTR Clone for TRIM65 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM65 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM65 | | OriGene Custom Protein Services for TRIM65 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM65 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM65 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM65 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM65 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM65 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM65 |
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| | | | Search Tocris compounds for TRIM65 |
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 | | | TRIM65 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM65 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM65 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM65 |
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