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Aliases for TRIM65 Gene

Aliases for TRIM65 Gene

  • Tripartite Motif Containing 65 2 3
  • Tripartite Motif-Containing Protein 65 3
  • Tripartite Motif-Containing 65 2
  • 4732463G12Rik 3

External Ids for TRIM65 Gene

Previous GeneCards Identifiers for TRIM65 Gene

  • GC17M071397
  • GC17M073885
  • GC17M069310

Summaries for TRIM65 Gene

GeneCards Summary for TRIM65 Gene

TRIM65 (Tripartite Motif Containing 65) is a Protein Coding gene. An important paralog of this gene is TRIM16L.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM65 Gene

Genomics for TRIM65 Gene

Regulatory Elements for TRIM65 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM65 Gene

Start:
75,880,335 bp from pter
End:
75,897,003 bp from pter
Size:
16,669 bases
Orientation:
Minus strand

Genomic View for TRIM65 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM65 Gene

Proteins for TRIM65 Gene

  • Protein details for TRIM65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ69-TRI65_HUMAN
    Recommended name:
    Tripartite motif-containing protein 65
    Protein Accession:
    Q6PJ69
    Secondary Accessions:
    • Q4G0F0
    • Q6DKJ6
    • Q9BRP6

    Protein attributes for TRIM65 Gene

    Size:
    517 amino acids
    Molecular mass:
    57353 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TRIM65 Gene

Proteomics data for TRIM65 Gene at MOPED

Post-translational modifications for TRIM65 Gene

  • Ubiquitination at Lys206
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM65 Gene

No data available for DME Specific Peptides for TRIM65 Gene

Domains for TRIM65 Gene

Gene Families for TRIM65 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Suggested Antigen Peptide Sequences for TRIM65 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PJ69

UniProtKB/Swiss-Prot:

TRI65_HUMAN :
  • Q6PJ69
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM65: view

Function for TRIM65 Gene

Gene Ontology (GO) - Molecular Function for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM65: view

Phenotypes for TRIM65 Gene

GenomeRNAi human phenotypes for TRIM65:
genes like me logo Genes that share phenotypes with TRIM65: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM65

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM65 Gene

Localization for TRIM65 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM65 Gene COMPARTMENTS Subcellular localization image for TRIM65 gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM65: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM65 Gene

Pathways for TRIM65 Gene

SuperPathways for TRIM65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM65 Gene

None

No data available for Pathways by source for TRIM65 Gene

Transcripts for TRIM65 Gene

Unigene Clusters for TRIM65 Gene

Tripartite motif containing 65:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM65

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM65 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM65 Gene

GeneLoc Exon Structure for
TRIM65
ECgene alternative splicing isoforms for
TRIM65

Expression for TRIM65 Gene

mRNA expression in normal human tissues for TRIM65 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM65 Gene

SOURCE GeneReport for Unigene cluster for TRIM65 Gene Hs.189823

genes like me logo Genes that share expressions with TRIM65: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM65 Gene

Orthologs for TRIM65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM65 35
  • 99.18 (n)
  • 98.56 (a)
TRIM65 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM65 35
  • 83.3 (n)
  • 76.73 (a)
TRIM65 36
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM65 35
  • 81.45 (n)
  • 75 (a)
TRIM65 36
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim65 35
  • 75.02 (n)
  • 64.66 (a)
Trim65 16
Trim65 36
  • 64 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM65 36
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM65 36
  • 23 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim65 35
  • 73.57 (n)
  • 64.65 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 21 (a)
ManyToMany
TRIM65 35
  • 55.1 (n)
  • 42.3 (a)
lizard
(Anolis carolinensis)
Reptilia TRIM65 36
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim65 35
  • 45.26 (n)
  • 35.57 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100149099 35
  • 46.2 (n)
  • 34.23 (a)
trim65 36
  • 29 (a)
OneToOne
Species with no ortholog for TRIM65:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM65 Gene

ENSEMBL:
Gene Tree for TRIM65 (if available)
TreeFam:
Gene Tree for TRIM65 (if available)

Paralogs for TRIM65 Gene

Paralogs for TRIM65 Gene

Selected SIMAP similar genes for TRIM65 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRIM65: view

Variants for TRIM65 Gene

Sequence variations from dbSNP and Humsavar for TRIM65 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1551619 -- 75,889,724(+) TGTTC(C/T)CTGAG utr-variant-3-prime
rs3744027 -- 75,892,662(-) GGGAG(C/T)GGGGC intron-variant
rs3744028 -- 75,892,591(-) CCCTG(A/G)CCCTC intron-variant
rs3760128 - 75,890,807(+) GCCCC(A/G)GAGGG missense, reference
rs4393627 -- 75,891,915(-) TGACC(C/T)CTCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM65 Gene

Variant ID Type Subtype PubMed ID
dgv3264n71 CNV Loss 21882294
dgv3267n71 CNV Loss 21882294
nsv833545 CNV Gain 17160897
nsv908820 CNV Loss 21882294
nsv510728 CNV Loss 20534489
nsv908821 CNV Loss 21882294
nsv908822 CNV Loss 21882294
nsv908823 CNV Loss 21882294

Relevant External Links for TRIM65 Gene

HapMap Linkage Disequilibrium report
TRIM65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM65 Gene

Disorders for TRIM65 Gene

Relevant External Links for TRIM65

Genetic Association Database (GAD)
TRIM65
genes like me logo Genes that share disorders with TRIM65: view

No data available for UniProtKB/Swiss-Prot for TRIM65 Gene

Publications for TRIM65 Gene

  1. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. (PMID: 21681796) Fornage M. … Launer L.J. (Ann. Neurol. 2011) 3 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  5. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PMID: 19549727) Markson G. … Sanderson C.M. (Genome Res. 2009) 3

Products for TRIM65 Gene

Sources for TRIM65 Gene

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