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Aliases for TRIM65 Gene

Aliases for TRIM65 Gene

  • Tripartite Motif Containing 65 2 3 5
  • Tripartite Motif-Containing Protein 65 3
  • Tripartite Motif-Containing 65 2
  • 4732463G12Rik 3

External Ids for TRIM65 Gene

Previous GeneCards Identifiers for TRIM65 Gene

  • GC17M071397
  • GC17M073885
  • GC17M069310

Summaries for TRIM65 Gene

GeneCards Summary for TRIM65 Gene

TRIM65 (Tripartite Motif Containing 65) is a Protein Coding gene. An important paralog of this gene is MIR3614.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM65 Gene

Genomics for TRIM65 Gene

Regulatory Elements for TRIM65 Gene

Enhancers for TRIM65 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F076510 1.4 FANTOM5 Ensembl ENCODE 64.4 -617.6 -617636 7.7 HDGF PKNOX1 ARNT WRNIP1 SIN3A FEZF1 YBX1 ZNF2 ZNF416 ZNF207 UNK TRIM65 ENSG00000267342 ENSG00000266980 CDK3 ENSG00000267801 ENSG00000267546 HMGN2P43 ENSG00000264829 SPHK1
GH17F075852 1.1 FANTOM5 ENCODE 28.6 +42.1 42120 4.1 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 TRIM65 ENSG00000267342 UNK SUMO2 MFSD11 FBF1 CDK3 TRIM47 ENSG00000266980 NUP85
GH17F075782 0.6 ENCODE 25.7 +112.0 111983 5.3 CREB3L1 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF548 ZNF263 UNK NUP85 ENSG00000266980 NT5C MFSD11 TRIM65 ENSG00000267342 UNC13D ENSG00000267801 METTL23
GH17F076840 0.3 FANTOM5 23.7 -943.9 -943934 0.4 ZNF202 MAZ ZBTB2 ZNF48 ZBTB7A ZEB1 ZNF292 ZFHX2 ZNF366 IKZF1 ENSG00000267342 TRIM65 METTL23 ENSG00000267546 CDK3 MGAT5B UBE2O LINC00868 LINC02080
GH17F075857 1.3 FANTOM5 ENCODE 23.5 +37.9 37927 2.2 HDGF PKNOX1 ATF1 ARNT ELK1 GATA2 FOS REST TBX21 MBD2 TRIM65 TRIM47 H3F3B GRB2 UNC13D WBP2 UBALD2 FBF1 SAP30BP ACOX1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM65 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM65 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001353506 403 2001 HDGF ATF1 CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF48 ZNF2

Genomic Location for TRIM65 Gene

Chromosome:
17
Start:
75,880,335 bp from pter
End:
75,897,003 bp from pter
Size:
16,669 bases
Orientation:
Minus strand

Genomic View for TRIM65 Gene

Genes around TRIM65 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM65 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM65 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM65 Gene

Proteins for TRIM65 Gene

  • Protein details for TRIM65 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PJ69-TRI65_HUMAN
    Recommended name:
    Tripartite motif-containing protein 65
    Protein Accession:
    Q6PJ69
    Secondary Accessions:
    • Q4G0F0
    • Q6DKJ6
    • Q9BRP6

    Protein attributes for TRIM65 Gene

    Size:
    517 amino acids
    Molecular mass:
    57353 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73831.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TRIM65 Gene

Post-translational modifications for TRIM65 Gene

  • Ubiquitination at Lys 206
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TRIM65 Gene

Domains & Families for TRIM65 Gene

Gene Families for TRIM65 Gene

Suggested Antigen Peptide Sequences for TRIM65 Gene

Graphical View of Domain Structure for InterPro Entry

Q6PJ69

UniProtKB/Swiss-Prot:

TRI65_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM65: view

Function for TRIM65 Gene

Gene Ontology (GO) - Molecular Function for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM65: view
genes like me logo Genes that share phenotypes with TRIM65: view

Animal Models for TRIM65 Gene

MGI Knock Outs for TRIM65:

Animal Model Products

miRNA for TRIM65 Gene

miRTarBase miRNAs that target TRIM65

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM65 Gene

Localization for TRIM65 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM65 Gene COMPARTMENTS Subcellular localization image for TRIM65 gene
Compartment Confidence
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM65: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM65 Gene

Pathways & Interactions for TRIM65 Gene

SuperPathways for TRIM65 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM65 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010508 positive regulation of autophagy IMP 26347139
genes like me logo Genes that share ontologies with TRIM65: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM65 Gene

Transcripts for TRIM65 Gene

Unigene Clusters for TRIM65 Gene

Tripartite motif containing 65:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM65 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c
SP1: -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM65 Gene

GeneLoc Exon Structure for
TRIM65
ECgene alternative splicing isoforms for
TRIM65

Expression for TRIM65 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM65 Gene

Protein differential expression in normal tissues from HIPED for TRIM65 Gene

This gene is overexpressed in Serum (37.8) and Peripheral blood mononuclear cells (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM65 Gene



Protein tissue co-expression partners for TRIM65 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM65 Gene:

TRIM65

SOURCE GeneReport for Unigene cluster for TRIM65 Gene:

Hs.189823
genes like me logo Genes that share expression patterns with TRIM65: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM65 Gene

Orthologs for TRIM65 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM65 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM65 34 35
  • 99.18 (n)
cow
(Bos Taurus)
Mammalia TRIM65 34 35
  • 83.3 (n)
dog
(Canis familiaris)
Mammalia TRIM65 34 35
  • 81.45 (n)
mouse
(Mus musculus)
Mammalia Trim65 34 16 35
  • 75.02 (n)
rat
(Rattus norvegicus)
Mammalia Trim65 34
  • 73.57 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM65 35
  • 45 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM65 35
  • 23 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM65 34
  • 55.1 (n)
-- 35
  • 21 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TRIM65 35
  • 22 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim65 34
  • 45.26 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100149099 34
  • 46.2 (n)
trim65 35
  • 29 (a)
OneToOne
Species where no ortholog for TRIM65 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM65 Gene

ENSEMBL:
Gene Tree for TRIM65 (if available)
TreeFam:
Gene Tree for TRIM65 (if available)

Paralogs for TRIM65 Gene

Paralogs for TRIM65 Gene

(6) SIMAP similar genes for TRIM65 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TRIM65: view

Variants for TRIM65 Gene

Sequence variations from dbSNP and Humsavar for TRIM65 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs111265650 -- 75,882,246(+) TCTGT(C/T)GCCCA intron-variant, downstream-variant-500B
rs111343860 -- 75,884,381(+) TTGAA(A/C/T)CCAGG intron-variant
rs111416102 -- 75,897,922(+) ACTGC(C/T)GCAGC upstream-variant-2KB
rs111468222 -- 75,897,074(+) GCCCG(A/G)GAAGG upstream-variant-2KB
rs111623110 -- 75,894,265(+) CCCTG(A/C)GCCAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM65 Gene

Variant ID Type Subtype PubMed ID
esv3641269 CNV loss 21293372
nsv510728 CNV deletion 20534489
nsv833545 CNV gain 17160897

Variation tolerance for TRIM65 Gene

Gene Damage Index Score: 8.02; 84.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM65 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM65

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM65 Gene

Disorders for TRIM65 Gene

Relevant External Links for TRIM65

Genetic Association Database (GAD)
TRIM65
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM65

No disorders were found for TRIM65 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM65 Gene

Publications for TRIM65 Gene

  1. Genome-wide association studies of cerebral white matter lesion burden: the CHARGE consortium. (PMID: 21681796) Fornage M. … Launer L.J. (Ann. Neurol. 2011) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  4. TRIM65 negatively regulates p53 through ubiquitination. (PMID: 27012201) Li Y. … Yu Z. (Biochem. Biophys. Res. Commun. 2016) 3 64
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64

Products for TRIM65 Gene

Sources for TRIM65 Gene

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