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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM64C Gene

protein-coding   GIFtS: 27
GCID: GC11M049075

Tripartite Motif Containing 64C

(Previous name: tripartite motif-containing 64C)
  Search for TRIM64C
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 64C1 2
Tripartite Motif-Containing 64C1 2
Putative Tripartite Motif-Containing Protein 64C2

External Ids:    HGNC: 371481   Entrez Gene: 6467542   Ensembl: ENSG000002148917   UniProtKB: A6NLI53   

Export aliases for TRIM64C gene to outside databases

Previous GC identifers: GC11M049038 GC11M048793


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIM64C Gene: 
TRIM64C (tripartite motif containing 64C) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is TRIML2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_009237.18  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRIM64C
         Other transcription factors

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Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM64C


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p11.12   Ensembl cytogenetic band:  11p11.12   HGNC cytogenetic band: 11p11.12

TRIM64C Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM64C gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M049075:  view genomic region     (about GC identifiers)

Start:
49,075,266 bp from pter      End:
49,080,664 bp from pter
Size:
5,399 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TR64C_HUMAN, A6NLI5 (See protein sequence)
Recommended Name: Putative tripartite motif-containing protein 64C  
Size: 447 amino acids; 51329 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for TRIM64C: NX_A6NLI5

TRIM64C Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

REFSEQ proteins: NP_001193560.1  
ENSEMBL proteins: 
 ENSP00000431987  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular IEA--

TRIM64C for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
HGNC Gene Families: 
TRIM: Tripartite motif containing / Tripartite motif containing

5/8 InterPro protein domains (see all 8):
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR000315 Znf_B-box

Graphical View of Domain Structure for InterPro Entry A6NLI5

ProtoNet protein and cluster: A6NLI5

UniProtKB/Swiss-Prot: TR64C_HUMAN, A6NLI5
Similarity: Belongs to the TRIM/RBCC family
Similarity: Contains 1 B box-type zinc finger
Similarity: Contains 1 B30.2/SPRY domain
Similarity: Contains 1 RING-type zinc finger


TRIM64C for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0008270zinc ion binding IEA--
     
TRIM64C for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM64C

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
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Browse Tocris compounds for TRIM64C (TR64C)

Search CenterWatch for drugs/clinical trials and news about TRIM64C / TR64C

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TRIM64C gene: 
NM_001206631.1  

Unigene Cluster for TRIM64C:

Tripartite motif containing 64C
Hs.740240
Unigene Representative Sequence: NM_001206631
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000530230(uc021qiy.1)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TRIM64C expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRIM64C Expression
About this image


SOURCE GeneReport for Unigene cluster: Hs.740240
    SABiosciences Custom PCR Arrays for TRIM64C
Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of mammals.

Orthologs for TRIM64C gene from 1/5 species (see all 5)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
dog
(Canis familiaris)
Mammalia --
--
56(a)
1 → many
21(10382458-10388785)


ENSEMBL Gene Tree for TRIM64C (if available)
TreeFam Gene Tree for TRIM64C (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TRIM64C gene
TRIML22  TRIM432  TRIML12  TRIM772  TRIM492  TRIM64B2  TRIM49B2  TRIM49C2  
TRIM512  TRIM482  TRIM49D12  
18/27 SIMAP similar genes for TRIM64C using alignment to 2 protein entries:     TR64C_HUMAN (see all proteins) (see all similar genes):
TRIM64    TRIM64B    TRIM41    TRIM43    TRIM43B    TRIM6
TRIM49C    TRIM49B    TRIM51    BRCA1    TRIM77    TRIM48
BMI1    PCGF3    MEFV    TRIM27    TRIM21    TRIML1

TRIM64C for paralogs           About GeneDecksing


1 Pseudogenes.org Pseudogene for TRIM64C
PGOHUM00000240791


(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/165 SNPs in TRIM64C are shown (see all 165)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs116002411,2
C,F,H--49074959(+) AGTGTC/GATATA 1 -- ds50011Minor allele frequency- G:0.00NA 2
rs1824623931,2
C--49075021(+) ATGAAC/TCTCAA 1 -- ds50010--------
rs2010504781,2
C--49075023(+) GAACCC/TCAACA 1 -- ds50010--------
rs1860825341,2
--49075069(+) GTAAAA/GGTTCC 1 -- ds50010--------
rs1908043021,2
--49075123(+) CATTCA/GAGGTG 1 -- ds50010--------
rs729045011,2
C,F--49075533(+) GCTGTC/TCTAGA 2 R syn11Minor allele frequency- T:0.02EU 591
rs1467830671,2
--49075547(+) TCGACA/TGACTC 2 S C mis10--------
rs1830717971,2
--49075570(+) TGGAGA/GAGTGG 2 S F mis10--------
rs1489201281,2
--49075597(+) AGTAAC/TGCTTG 2 H R mis10--------
rs28515351,2
C,F,H--49075605(-) ACCTCT/CGGCAA 2 /S syn114Minor allele frequency- C:0.19NA WA CSA EA EU 964

HapMap Linkage Disequilibrium report for TRIM64C (49075266 - 49080664 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10/11 variations for TRIM64C (see all 11):    About this table     
Variant IDTypeSubtypePubMed ID
esv2671725CNV Deletion23128226
esv2744485CNV Deletion23290073
esv2666171CNV Deletion23128226
esv2421548CNV Deletion20811451
nsv897484CNV Loss21882294
dgv1129n71CNV Loss21882294
nsv469956CNV Gain18288195
nsv467874CNV Gain19166990
nsv832145CNV Gain17160897
esv542CNV CNV17122850

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TRIM64C gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM64C)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
  2. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (2012)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 646754 HGNC: 37148 Ensembl:ENSG00000214891 euGenes: HUgn646754 ECgene: TRIM64C
H-InvDB: TRIM64C

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TRIM64C Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TRIM64C gene:
Search GeneIP for patents involving TRIM64C

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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