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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM64B Gene

protein-coding   GIFtS: 29
GCID: GC11M089603

Tripartite Motif Containing 64B

(Previous name: tripartite motif-containing 64B)
  Search for TRIM64B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 64B1 2
Tripartite Motif-Containing 64B1 2
Putative Tripartite Motif-Containing Protein 64B2

External Ids:    HGNC: 371471   Entrez Gene: 6424462   Ensembl: ENSG000001892537   UniProtKB: A6NI033   

Export aliases for TRIM64B gene to outside databases

Previous GC identifer: GC11M089248


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIM64B Gene: 
TRIM64B (tripartite motif containing 64B) is a protein-coding gene. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is TRIML2.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NC_018922.2  NT_167190.1  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TRIM64B
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TRIM64B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM64B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q14.3   Ensembl cytogenetic band:  11q14.3   HGNC cytogenetic band: 11q14.3

TRIM64B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM64B gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M089603:  view genomic region     (about GC identifiers)

Start:
89,602,450 bp from pter      End:
89,609,185 bp from pter
Size:
6,736 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TR64B_HUMAN, A6NI03 (See protein sequence)
Recommended Name: Putative tripartite motif-containing protein 64B  
Size: 449 amino acids; 51557 Da
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for TRIM64B: NX_A6NI03

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A6NI03

  • TRIM64B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins: NP_001157869.1  
    ENSEMBL proteins: 
     ENSP00000332969  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    TRIM64B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing

    5/9 InterPro protein domains (see all 9):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt
     IPR000315 Znf_B-box

    Graphical View of Domain Structure for InterPro Entry A6NI03

    ProtoNet protein and cluster: A6NI03

    UniProtKB/Swiss-Prot: TR64B_HUMAN, A6NI03
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM64B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    TRIM64B for ontologies           About GeneDecksing


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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM64B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Search CenterWatch for drugs/clinical trials and news about TRIM64B / TR64B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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    About This Section

    REFSEQ mRNAs for TRIM64B gene: 
    NM_001164397.1  

    Unigene Cluster for TRIM64B:

    Tripartite motif containing 64B
    Hs.730588
    Unigene Representative Sequence: NM_001164397
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329862(uc021qoo.1)
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    Additional mRNA sequence: JF968449.1 
    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM64B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRIM64B Expression
    About this image


    SOURCE GeneReport for Unigene cluster: Hs.730588
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of mammals.

    Orthologs for TRIM64B gene from 1/5 species (see all 5)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    --
    57(a)
    1 → many
    21(10382458-10388785)


    ENSEMBL Gene Tree for TRIM64B (if available)
    TreeFam Gene Tree for TRIM64B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM64B gene
    TRIM64  TRIML22  TRIM432  TRIML12  TRIM772  TRIM492  TRIM49B2  TRIM64C2  
    TRIM49C2  TRIM512  TRIM482  TRIM49D12  
    18/24 SIMAP similar genes for TRIM64B using alignment to 1 protein entry:     TR64B_HUMAN(see all similar genes):
    TRIM64    TRIM64C    TRIM41    TRIM43    TRIM43B    TRIM49C
    TRIM49B    TRIM51    MEFV    TRIM48    TRIM77    BRCA1
    TRIM39    BMI1    TRIM27    TRIML1    TRIM21    TRIM49

    TRIM64B for paralogs           About GeneDecksing


    5/9 Pseudogenes.org Pseudogenes for TRIM64B (see all 9)
    PGOHUM00000257812 PGOHUM00000257856 PGOHUM00000257857 PGOHUM00000257906 PGOHUM00000257907


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/83 SNPs in TRIM64B are shown (see all 83)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1426000771,2
    --89603190(+) GATGAA/GATATC 1 -- ds50010--------
    rs2021695251,2
    F--89603924(+) CCAACT/CCGACC 2 /R syn11Minor allele frequency- C:0.01EU 563
    rs1861515631,2
    --89603925(+) CAACTC/TGACCC 2 Q R mis10--------
    rs2017750051,2
    C--89604037(+) AATAAC/TGAAAT 2 I V mis11Minor allele frequency- T:0.00EU 589
    rs2001436651,2
    C,F--89604264(+) TTTCCG/CTGCTC 2 /T /R mis11Minor allele frequency- C:0.06EU 547
    rs1504250741,2
    C--89604544(+) TAGTTG/TGTTTC 1 -- int10--------
    rs1909622281,2
    C--89604569(+) ATGTTC/TTTTTT 1 -- int10--------
    rs1380566891,2
    --89604588(+) AGAAAA/GCTCTC 1 -- int10--------
    rs1387668761,2
    --89605822(+) CTTTGC/GGACCT 1 -- int10--------
    rs1418210631,2
    --89605840(+) CAGTTA/GTCACT 1 -- int10--------

    HapMap Linkage Disequilibrium report for TRIM64B (89602450 - 89609185 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/17 variations for TRIM64B (see all 17):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv1257n71CNV Loss21882294
    dgv1261n71CNV Loss21882294
    dgv1259n71CNV Loss21882294
    dgv1258n71CNV Loss21882294
    dgv1260n71CNV Loss21882294
    nsv898111CNV Loss21882294
    nsv508645CNV Loss20534489
    dgv1256n71CNV Loss21882294
    nsv898118CNV Gain21882294
    nsv898094CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM64B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRIM64B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
    2. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PubMed id 22144910)1 Han K.... Sawyer S.L. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 642446 HGNC: 37147 Ensembl:ENSG00000189253 euGenes: HUgn642446 ECgene: TRIM64B
    H-InvDB: TRIM64B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM64B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM64B gene:
    Search GeneIP for patents involving TRIM64B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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     Search LifeMap BioReagents cell lines for TRIM64B
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM64B
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TRIM64B
     Browse SwitchGear Promoter luciferase reporter plasmids for TRIM64B
     Search ThermoFisher Antibodies for TRIM64B
     Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM64B
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TRIM64B
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TRIM64B
    Customized:
     lentivirus for stable overexpression of TRIM64B
     lentivirus expression plasmids for stable overexpression of TRIM64B
     adenovirus for overexpression of TRIM64B
     Search LSBio for Antibodies for TRIM64B
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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