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Aliases for TRIM63 Gene

Aliases for TRIM63 Gene

  • Tripartite Motif Containing 63 2 3
  • Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase 2 3 5
  • Striated Muscle RING Zinc Finger Protein 2 3 4
  • Muscle-Specific RING Finger Protein 1 2 3 4
  • Tripartite Motif-Containing Protein 63 3 4
  • Iris Ring Finger Protein 2 3
  • Ring Finger Protein 28 2 3
  • RNF28 3 4
  • MURF1 3 4
  • SMRZ 3 4
  • IRF 3 4
  • Muscle Specific Ring Finger Protein 2 3
  • Iris RING Finger Protein 4
  • RING Finger Protein 28 4
  • EC 6.3.2.- 4
  • MuRF-1 4
  • MuRF2 3

External Ids for TRIM63 Gene

Previous HGNC Symbols for TRIM63 Gene

  • RNF28

Previous GeneCards Identifiers for TRIM63 Gene

  • GC01M026250
  • GC01M026377
  • GC01M024631

Summaries for TRIM63 Gene

Entrez Gene Summary for TRIM63 Gene

  • This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

GeneCards Summary for TRIM63 Gene

TRIM63 (Tripartite Motif Containing 63) is a Protein Coding gene. Diseases associated with TRIM63 include Human Herpesvirus 8 and Muscle Tissue Disease. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity and signal transducer activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM63 Gene

  • E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Gene Wiki entry for TRIM63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM63 Gene

Genomics for TRIM63 Gene

Regulatory Elements for TRIM63 Gene

Enhancers for TRIM63 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM63 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM63 Gene

Chromosome:
1
Start:
26,051,304 bp from pter
End:
26,068,436 bp from pter
Size:
17,133 bases
Orientation:
Minus strand

Genomic View for TRIM63 Gene

Genes around TRIM63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM63 Gene

Proteins for TRIM63 Gene

  • Protein details for TRIM63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q1-TRI63_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM63
    Protein Accession:
    Q969Q1
    Secondary Accessions:
    • B4DN95
    • Q5T2I1
    • Q96BD3
    • Q96KD9
    • Q9BYV4

    Protein attributes for TRIM63 Gene

    Size:
    353 amino acids
    Molecular mass:
    40248 Da
    Quaternary structure:
    • Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with RACK1 and PRKCE (By similarity). Interacts with CKM.
    SequenceCaution:
    • Sequence=AAK52497.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAK52497.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAC33173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM63 Gene

    Alternative splice isoforms for TRIM63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM63 Gene

Proteomics data for TRIM63 Gene at MOPED

Post-translational modifications for TRIM63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM63 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for TRIM63 (MuRF1/TRIM63)
  • Abcam antibodies for MURF1

No data available for DME Specific Peptides for TRIM63 Gene

Domains & Families for TRIM63 Gene

Gene Families for TRIM63 Gene

Suggested Antigen Peptide Sequences for TRIM63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q1

UniProtKB/Swiss-Prot:

TRI63_HUMAN :
  • The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity).
  • Contains 1 B box-type zinc finger.
Domain:
  • The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity).
  • The B box-type zinc finger mediates homodimerization.
  • Contains 1 COS domain.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM63: view

Function for TRIM63 Gene

Molecular function for TRIM63 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Enzyme Numbers (IUBMB) for TRIM63 Gene

Gene Ontology (GO) - Molecular Function for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
genes like me logo Genes that share ontologies with TRIM63: view
genes like me logo Genes that share phenotypes with TRIM63: view

Animal Models for TRIM63 Gene

MGI Knock Outs for TRIM63:

Animal Model Products

CRISPR Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM63 Gene

Localization for TRIM63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM63 Gene

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM63 Gene COMPARTMENTS Subcellular localization image for TRIM63 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
cytosol 2
lysosome 2
mitochondrion 2
vacuole 2
golgi apparatus 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM63: view

Pathways & Interactions for TRIM63 Gene

genes like me logo Genes that share pathways with TRIM63: view

Pathways by source for TRIM63 Gene

UniProtKB/Swiss-Prot Q969Q1-TRI63_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

SIGNOR curated interactions for TRIM63 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0014732 skeletal muscle atrophy IEA --
genes like me logo Genes that share ontologies with TRIM63: view

Drugs & Compounds for TRIM63 Gene

(9) Drugs for TRIM63 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0

(5) Additional Compounds for TRIM63 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with TRIM63: view

Transcripts for TRIM63 Gene

mRNA/cDNA for TRIM63 Gene

Unigene Clusters for TRIM63 Gene

Tripartite motif containing 63, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM63 Gene

No ASD Table

Relevant External Links for TRIM63 Gene

GeneLoc Exon Structure for
TRIM63
ECgene alternative splicing isoforms for
TRIM63

Expression for TRIM63 Gene

mRNA expression in normal human tissues for TRIM63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM63 Gene

This gene is overexpressed in Muscle - Skeletal (x42.8) and Heart - Left Ventricle (x6.0).

Protein differential expression in normal tissues from HIPED for TRIM63 Gene

This gene is overexpressed in Fetal heart (54.2) and Heart (14.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM63 Gene



SOURCE GeneReport for Unigene cluster for TRIM63 Gene Hs.279709

mRNA Expression by UniProt/SwissProt for TRIM63 Gene

Q969Q1-TRI63_HUMAN
Tissue specificity: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
genes like me logo Genes that share expression patterns with TRIM63: view

Protein tissue co-expression partners for TRIM63 Gene

- Elite partner

Primer Products

Orthologs for TRIM63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM63 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM63 35
  • 91.54 (n)
  • 93.27 (a)
TRIM63 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM63 35
  • 90.72 (n)
  • 93.58 (a)
TRIM63 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim63 35
  • 88.18 (n)
  • 93.58 (a)
Trim63 16
Trim63 36
  • 92 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM63 35
  • 99.62 (n)
  • 99.72 (a)
TRIM63 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim63 35
  • 87.16 (n)
  • 92.35 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM63 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM63 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM63 35
  • 77.51 (n)
  • 76.69 (a)
TRIM63 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM63 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim63 35
  • 67.81 (n)
  • 68.54 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc56376 35
trim54 36
  • 43 (a)
ManyToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6549 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for TRIM63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM63 Gene

ENSEMBL:
Gene Tree for TRIM63 (if available)
TreeFam:
Gene Tree for TRIM63 (if available)

Paralogs for TRIM63 Gene

(2) SIMAP similar genes for TRIM63 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM63: view

Variants for TRIM63 Gene

Sequence variations from dbSNP and Humsavar for TRIM63 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2275950 - 26,058,512(-) AGGAG(A/C/G)AAAAG reference, missense
VAR_074092 -
VAR_074093 -
VAR_074094 -
VAR_074095 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM63 Gene

Variant ID Type Subtype PubMed ID
nsv834513 CNV Gain 17160897
nsv871353 CNV Loss 21882294
nsv508678 CNV Loss 20534489

Variation tolerance for TRIM63 Gene

Residual Variation Intolerance Score: 64.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.36; 81.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM63 Gene

Human Gene Mutation Database (HGMD)
TRIM63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM63 Gene

Disorders for TRIM63 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM63 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
human herpesvirus 8
  • kaposi sarcoma
muscle tissue disease
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM63

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM63
genes like me logo Genes that share disorders with TRIM63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM63 Gene

Publications for TRIM63 Gene

  1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 3 4 67
  2. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms. (PMID: 19850579) Mearini G. … Carrier L. (Cardiovasc. Res. 2010) 3 23
  3. Depressed expression of MuRF1 and MAFbx in areas remote of recent myocardial infarction: a mechanism contributing to myocardial remodeling? (PMID: 19859778) Conraads V.M. … Adams V. (Basic Res. Cardiol. 2010) 3 23
  4. MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. (PMID: 18468620) Hirner S. … Labeit D. (J. Mol. Biol. 2008) 3 23
  5. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PMID: 11927605) McElhinny A.S. … Gregorio C.C. (J. Cell Biol. 2002) 3 23

Products for TRIM63 Gene

Sources for TRIM63 Gene

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