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TRIM63 Gene

protein-coding   GIFtS: 61
GCID: GC01M026377

Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase

(Previous names: ring finger protein 28, tripartite motif-containing 63,...)
(Previous symbol: RNF28)
  See TRIM63-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase1 2     IRF2 3
RNF281 2 3 5     Tripartite Motif Containing 631
RING Finger Protein 281 2 3     Tripartite Motif-Containing 631
Iris RING Finger Protein1 2 3     MURF22
Muscle-Specific RING Finger Protein 11 2 3     E3 Ubiquitin-Protein Ligase TRIM632
Striated Muscle RING Zinc Finger Protein1 2 3     Muscle Specific Ring Finger Protein 22
MURF12 3 5     EC 6.3.2.-3
SMRZ2 3 5     MuRF-13
Tripartite Motif-Containing Protein 632 3     MuRF13

External Ids:    HGNC: 160071   Entrez Gene: 846762   Ensembl: ENSG000001580227   OMIM: 6061315   UniProtKB: Q969Q13   

Export aliases for TRIM63 gene to outside databases

Previous GC identifers: GC01M026062 GC01M026250 GC01M024631


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM63 Gene:
This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product
of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This
protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation
of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase.
(provided by RefSeq, Feb 2012)

GeneCards Summary for TRIM63 Gene:
TRIM63 (tripartite motif containing 63, E3 ubiquitin protein ligase) is a protein-coding gene. Diseases associated with TRIM63 include myopathy of critical illness, and alveolar soft part sarcoma. GO annotations related to this gene include ubiquitin-protein ligase activity and titin binding. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot: TRI63_HUMAN, Q969Q1
Function: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1
and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle
protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein
synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably
of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating
an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in
muscle cells

Gene Wiki entry for TRIM63 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NC_018912.2  NT_032977.10  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM63 gene promoter:
         Max1   USF1   STAT1   Sp1   CP2   USF-1   IRF-7A   ZIC2/Zic2   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM63 promoter sequence
   Search Chromatin IP Primers for TRIM63

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM63


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p34-p33   Ensembl cytogenetic band:  1p36.11   HGNC cytogenetic band: 1p34-p33

TRIM63 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM63 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M026377:  view genomic region     (about GC identifiers)

Start:
26,377,795 bp from pter      End:
26,394,927 bp from pter
Size:
17,133 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI63_HUMAN, Q969Q1 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM63  
Size: 353 amino acids; 40248 Da
Subunit: Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with
TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE (By similarity).
Interacts with CKM
Developmental stage: Expressed throughout all developmental stages
Caution: It is uncertain whether Met-1 or Met-14 is the initiator
Sequence caution: Sequence=AAK52497.1; Type=Frameshift; Positions=Several; Sequence=AAK52497.1; Type=Miscellaneous
discrepancy; Note=Sequencing errors; Sequence=CAC33173.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for TRIM63:
2D8U (3D)        3DDT (3D)    
Secondary accessions: Q5T2I1 Q96BD3 Q96KD9 Q9BYV4

Explore the universe of human proteins at neXtProt for TRIM63: NX_Q969Q1

Explore proteomics data for TRIM63 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM63 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_115977.2  
    ENSEMBL proteins: 
     ENSP00000363390  
    Reactome Protein details: Q969Q1

    TRIM63 Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for TRIM63

     
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    Search eBioscience for ELISAs for TRIM63 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR017903 COS_domain
     IPR000315 Znf_B-box
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q969Q1

    ProtoNet protein and cluster: Q969Q1

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI63_HUMAN, Q969Q1
    Domain: The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required
    for the E3 ubiquitin ligase activity (By similarity)
    Domain: The B box-type zinc finger mediates homodimerization
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM63           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI63_HUMAN, Q969Q1
    Function: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1
    and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle
    protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein
    synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably
    of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating
    an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in
    muscle cells

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0004871signal transducer activity NAS11243782
    GO:0005515protein binding IPI18157088
    GO:0008270zinc ion binding IEA--
    GO:0031432titin binding IDA11927605
         
    Find genes that share ontologies with TRIM63           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM63:
     Decreased viability with pacli  Increased G2M DNA content, inc 

         8 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Trim63):
     adipose tissue  cardiovascular system  growth/size/body  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  respiratory system 

    Find genes that share phenotypes with TRIM63           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TRIM63: Trim63tm1Slbt Trim63tm2.1Vlcg

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM63
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM63
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM63

    miRNA
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    miRTarBase miRNAs that target TRIM63:
    hsa-mir-335-5p (MIRT017998), hsa-mir-29a-3p (MIRT005909)

    Block miRNA regulation of human, mouse, rat TRIM63 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM63 (see all 20):
    hsa-miR-498 hsa-miR-300 hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-507 hsa-miR-3921 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIM63 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM63

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: TRIM63 (NM_032588)
    Sino Biological Human cDNA Clone for TRIM63
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI63_HUMAN, Q969Q1: Cytoplasm. Nucleus (By similarity). Cytoplasm, myofibril, sarcomere, M line. Cytoplasm,
    myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and
    Z-lines in skeletal muscle
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    golgi apparatus1
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm NAS11243782
    GO:0005874microtubule NAS11243782
    GO:0030018Z disc IEA--

    Find genes that share ontologies with TRIM63           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM63 About    
    See pathways by source

    SuperPathContained pathways About
    1Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    2TWEAK Pathway
    TWEAK Signaling Pathway0.31


    Find genes that share SuperPaths with TRIM63           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 BioSystems Pathway for TRIM63
        TWEAK Signaling Pathway


    1 Reactome Pathway for TRIM63
        Antigen processing: Ubiquitination & Proteasome degradation


    UniProtKB/Swiss-Prot: TRI63_HUMAN, Q969Q1
    Pathway: Protein modification; protein ubiquitination

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM63: 

              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for TRIM63

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TRIM63 (Q969Q11, 2, 3 ENSP000003633904) via UniProtKB, MINT, STRING, and/or I2D (see all 66)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFM1Q96RP91, 2, 3, ENSP000004190384EBI-5661333,EBI-2255048 MINT-6492209 MINT-6503520 I2D: score=1 STRING: ENSP00000419038
    TTNQ8WZ421, 2, 3EBI-5661333,EBI-681210 MINT-6503430 MINT-6503580 I2D: score=2 
    EEF1GP266411, 2, 3EBI-5661333,EBI-351467 MINT-6492197 MINT-6503480 I2D: score=1 
    GMEB1Q9Y6922, 3, ENSP000002944094MINT-6503470 I2D: score=3 STRING: ENSP00000294409
    SQSTM1Q135012, 3, ENSP000003744554MINT-6503660 I2D: score=2 STRING: ENSP00000374455
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936muscle contraction IEA--
    GO:0007165signal transduction NAS11243782
    GO:0010468regulation of gene expression IEA--
    GO:0014732skeletal muscle atrophy IEA--
    GO:0014878response to electrical stimulus involved in regulation of muscle adaptation ISS--

    Find genes that share ontologies with TRIM63           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM63 (TRI63)

    4 HMDB Compounds for TRIM63    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--

    10 Novoseek inferred chemical compound relationships for TRIM63 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    diamide 38.8 3 7508861 (1), 1738601 (1)
    rantes 35.3 2 10893229 (1), 20197549 (1)
    2-mercaptoethanol 33.2 4 2157191 (1), 7508861 (1), 1738601 (1)
    iron 27.4 39 8464737 (4), 8130687 (4), 7508861 (3), 7741221 (3) (see all 11)
    serine 24.9 2 11846979 (1), 17200120 (1)
    5-aminolevulinic acid 23 2 8021254 (1), 7881153 (1)
    tyrosine 5.01 5 17200120 (3), 9765473 (2)
    retinoic acid 3.63 2 9669677 (2)
    lysine 0 1 12374802 (1)
    nitric oxide 0 2 15296650 (1), 7881153 (1)



    Find genes that share compounds with TRIM63           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM63 gene: 
    NM_032588.3  

    Unigene Cluster for TRIM63:

    Tripartite motif containing 63, E3 ubiquitin protein ligase
    Hs.279709  [show with all ESTs]
    Unigene Representative Sequence: AF353673
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000374272(uc001bli.1) ENST00000483052
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TRIM63 (see all 20):
    hsa-miR-498 hsa-miR-300 hsa-miR-29a hsa-miR-29c hsa-miR-767-5p hsa-miR-507 hsa-miR-3921 hsa-miR-23a
    SwitchGear 3'UTR luciferase reporter plasmidTRIM63 3' UTR sequence
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      QuantiFast Probe-based Assays in human, mouse, rat TRIM63

    Additional mRNA sequence: 

    AF353673.1 AJ276484.1 AK056942.1 AK297820.1 BC080529.1 BT007373.1 

    2 DOTS entries:

    DT.436990  DT.95264585 

    Selected AceView cDNA sequences (see all 30):

    BI754358 BF724411 F35868 AI351421 BX500821 BG761218 BC080529 F36292 
    BG764060 BG769996 AF353673 AJ276484 C02645 BX500807 BG765856 BX283938 
    BI758535 AK056942 NM_032588 F21990 AW296154 F25523 F34432 BE894237 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM63 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GACTTCTTTA
    TRIM63 Expression
    About this image


    TRIM63 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 4) fully expand
     
     Bone (Muscoskeletal System)
             Zeugopod Periosteum
     
     Kidney (Urinary System)
             Metanephric Mesenchyme Cells Metanephric Mesenchyme
     
     Heart (Cardiovascular System)
     
     Skeletal Muscle (Muscoskeletal System)
    TRIM63 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM63 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.279709

    UniProtKB/Swiss-Prot: TRI63_HUMAN, Q969Q1
    Tissue specificity: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the
    iris

        Pathway & Disease-focused RT2 Profiler PCR Arrays including TRIM63: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM63

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM63 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim631 , 5 tripartite motif-containing 631, 5 88.18(n)1
    93.58(a)1
      4 (66.58 cM)5
    4337661  NM_001039048.21  NP_001034137.21 
     1343151225 
    chicken
    (Gallus gallus)
    Aves TRIM631 tripartite motif containing 63, E3 ubiquitin protein more 77.51(n)
    76.69(a)
      426754  XM_424369.4  XP_424369.4 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM636
    tripartite motif containing 63, E3 ubiquitin prote...
    71(a)
    1 ↔ 1
    GL343480.1(295141-313859)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trim631 tripartite motif containing 63, E3 ubiquitin protein more 67.81(n)
    68.54(a)
      780012  NM_001079089.1  NP_001072557.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc563762 similar to ring finger protein 30 78.05(n)   394070  BC049414.1 


    ENSEMBL Gene Tree for TRIM63 (if available)
    TreeFam Gene Tree for TRIM63 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM63 gene
    TRIM132  FSD1L2  TRIM462  TRIM592  TRIM92  TRIM672  TRIM362  TRIM552  
    MID12  MID22  TRIM542  FSD12  
    2 SIMAP similar genes for TRIM63 using alignment to 1 protein entry:     TRI63_HUMAN:
    TRIM55    TRIM54

    Find genes that share paralogs with TRIM63           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM63 (see all 494)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75557961,2
    A--26377446(+) catgaA/Gccact 1 -- ds50010--------
    rs1898437451,2
    --26377456(+) TGCACC/TTGCCC 1 -- ds50010--------
    rs75513111,2
    A--26377523(+) GAGCAC/TGGGGA 1 -- ds50010--------
    rs66894071,2
    C,F,A,H--26377595(+) ccagaA/Gcaaca 1 -- ds500111Minor allele frequency- G:0.48NS EA NA WA 658
    rs67038211,2
    C,F,H--26377603(+) ACAACA/GCATTG 1 -- ds50016Minor allele frequency- G:0.01NS EA WA 538
    rs75559701,2
    A--26377605(+) aacaCA/GTTGAA 1 -- ds50010--------
    rs1511413931,2
    --26377608(+) ACATTA/GAACCT 1 -- ds50010--------
    rs1391449981,2
    --26377766(+) CCAGGA/GAAAAA 1 -- ds50010--------
    rs1818899871,2
    --26377774(+) AAAAGA/GCTGAA 1 -- ds50010--------
    rs75428151,2
    A,H--26377789(+) ACCCCG/AGCTCC 1 -- ds50014Minor allele frequency- A:0.00NS EA 418

    HapMap Linkage Disequilibrium report for TRIM63 (26377795 - 26394927 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TRIM63:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv508678CNV Loss20534489
    nsv871353CNV Loss21882294
    nsv834513CNV Gain17160897

    Human Gene Mutation Database (HGMD): TRIM63
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM63
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM63

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606131    OMIM disorders: --

    2 diseases for TRIM63:    
    About MalaCards
    myopathy of critical illness    alveolar soft part sarcoma

    3 diseases from the University of Copenhagen DISEASES database for TRIM63:
    Muscular atrophy     Myopathy of critical illness     Alveolar soft part sarcoma

    Find genes that share disorders with TRIM63           About GenesLikeMe

    5 Novoseek inferred disease relationships for TRIM63 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    virus infection 51.7 6 9463386 (1), 16751392 (1), 7536924 (1), 18440553 (1) (see all 6)
    atrophy 43.7 16 19168726 (3), 16250905 (1), 15100091 (1), 17008454 (1) (see all 9)
    kaposi sarcoma 30.1 2 11160738 (1), 11846976 (1)
    hypertrophy 0 3 19859778 (1), 15125842 (1)
    tumors 0 2 18511292 (1), 9669677 (1)


    Export disorders for TRIM63 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM63 gene, integrated from 10 sources (see all 161):
    (articles sorted by number of sources associating them with TRIM63)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PubMed id 11243782)1, 2, 3 Centner T....Labeit S. (J. Mol. Biol. 2001)
    2. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. (PubMed id 11283016)1, 2, 3 Dai K.-S. and Liew C.-C. (J. Biol. Chem. 2001)
    3. MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. (PubMed id 18468620)1, 2, 9 Hirner S.... Labeit D. (J. Mol. Biol. 2008)
    4. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PubMed id 11927605)1, 2, 9 McElhinny A.S.... Gregorio C.C. (J. Cell Biol. 2002)
    5. Structural analysis of B-Box 2 from MuRF1: identification of a novel self-association pattern in a RING-like fold. (PubMed id 18795805)1, 2 Mrosek M.... Mayans O. (Biochemistry 2008)
    6. Muscle RING-finger protein-1 (MuRF1) as a connector of muscle energy metabolism and protein synthesis. (PubMed id 18222470)1, 2 Koyama S.... Sorimachi H. (J. Mol. Biol. 2008)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Expressed sequence tag analysis of adult human iris for the NEIBank project: steroid-response factors and similarities with retinal pigment epithelium. (PubMed id 12107412)1, 2 Wistow G.... Peterson K. (Mol. Vis. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84676 HGNC: 16007 AceView: RNF28 Ensembl:ENSG00000158022 euGenes: HUgn84676
    ECgene: TRIM63 H-InvDB: TRIM63

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM63 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM63 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM63 gene:
    Search GeneIP for patents involving TRIM63

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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