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Aliases for TRIM63 Gene

Aliases for TRIM63 Gene

  • Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase 2 3
  • Striated Muscle RING Zinc Finger Protein 2 3 4
  • Muscle-Specific RING Finger Protein 1 2 3 4
  • RNF28 3 4 6
  • MURF1 3 4 6
  • SMRZ 3 4 6
  • Tripartite Motif-Containing Protein 63 3 4
  • Iris Ring Finger Protein 2 3
  • Ring Finger Protein 28 2 3
  • IRF 3 4
  • Muscle Specific Ring Finger Protein 2 3
  • E3 Ubiquitin-Protein Ligase TRIM63 3
  • Tripartite Motif-Containing 63 2
  • Tripartite Motif Containing 63 2
  • Iris RING Finger Protein 4
  • RING Finger Protein 28 4
  • EC 6.3.2.- 4
  • MuRF-1 4
  • MURF2 3

External Ids for TRIM63 Gene

Previous HGNC Symbols for TRIM63 Gene

  • RNF28

Previous GeneCards Identifiers for TRIM63 Gene

  • GC01M026250
  • GC01M026377
  • GC01M024631

Summaries for TRIM63 Gene

Entrez Gene Summary for TRIM63 Gene

  • This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]

GeneCards Summary for TRIM63 Gene

TRIM63 (Tripartite Motif Containing 63, E3 Ubiquitin Protein Ligase) is a Protein Coding gene. Diseases associated with TRIM63 include myopathy of critical illness. Among its related pathways are Class I MHC mediated antigen processing and presentation and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include ubiquitin-protein transferase activity and titin binding. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM63 Gene

  • E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Gene Wiki entry for TRIM63 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM63 Gene

Genomics for TRIM63 Gene

Regulatory Elements for TRIM63 Gene

Genomic Location for TRIM63 Gene

Start:
26,051,304 bp from pter
End:
26,068,436 bp from pter
Size:
17,133 bases
Orientation:
Minus strand

Genomic View for TRIM63 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM63 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM63 Gene

Proteins for TRIM63 Gene

  • Protein details for TRIM63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q969Q1-TRI63_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM63
    Protein Accession:
    Q969Q1
    Secondary Accessions:
    • B4DN95
    • Q5T2I1
    • Q96BD3
    • Q96KD9
    • Q9BYV4

    Protein attributes for TRIM63 Gene

    Size:
    353 amino acids
    Molecular mass:
    40248 Da
    Quaternary structure:
    • Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with GNB2L1 and PRKCE (By similarity). Interacts with CKM.
    SequenceCaution:
    • Sequence=AAK52497.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAK52497.1; Type=Miscellaneous discrepancy; Note=Sequencing errors.; Evidence={ECO:0000305}; Sequence=CAC33173.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM63 Gene

    Alternative splice isoforms for TRIM63 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM63 Gene

Proteomics data for TRIM63 Gene at MOPED

Post-translational modifications for TRIM63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM63 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM63 Gene

Domains for TRIM63 Gene

Gene Families for TRIM63 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM63 Gene

Suggested Antigen Peptide Sequences for TRIM63 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q969Q1

UniProtKB/Swiss-Prot:

TRI63_HUMAN :
  • Q969Q1
Domain:
  • The RING-type zinc finger mediates interaction with SUMO2 and localization to the nucleus. Also required for the E3 ubiquitin ligase activity (By similarity).
  • The B box-type zinc finger mediates homodimerization.
  • Contains 1 COS domain.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM63: view

Function for TRIM63 Gene

Molecular function for TRIM63 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.

Enzyme Numbers (IUBMB) for TRIM63 Gene

Gene Ontology (GO) - Molecular Function for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding IPI 18157088
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM63: view
genes like me logo Genes that share phenotypes with TRIM63: view

Animal Models for TRIM63 Gene

MGI Knock Outs for TRIM63:

miRNA for TRIM63 Gene

miRTarBase miRNAs that target TRIM63

No data available for Transcription Factor Targeting and HOMER Transcription for TRIM63 Gene

Localization for TRIM63 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM63 Gene

Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere, M line. Cytoplasm, myofibril, sarcomere, Z line. Note=Colocalizes with TNNI3 in myocytes (By similarity). Localizes to the M- and Z-lines in skeletal muscle. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM63 Gene COMPARTMENTS Subcellular localization image for TRIM63 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
golgi apparatus 1
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm NAS 11243782
GO:0005874 microtubule NAS 11243782
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with TRIM63: view

Pathways for TRIM63 Gene

genes like me logo Genes that share pathways with TRIM63: view

Pathways by source for TRIM63 Gene

UniProtKB/Swiss-Prot Q969Q1-TRI63_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Gene Ontology (GO) - Biological Process for TRIM63 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006936 muscle contraction IEA --
GO:0007165 signal transduction NAS 11243782
GO:0010468 regulation of gene expression IEA --
GO:0014732 skeletal muscle atrophy IEA --
GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation ISS --
genes like me logo Genes that share ontologies with TRIM63: view

Compounds for TRIM63 Gene

(4) HMDB Compounds for TRIM63 Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(10) Novoseek inferred chemical compound relationships for TRIM63 Gene

Compound -log(P) Hits PubMed IDs
diamide 38.8 2
rantes 35.3 2
2-mercaptoethanol 33.2 3
iron 27.4 23
serine 24.9 2
genes like me logo Genes that share compounds with TRIM63: view

Transcripts for TRIM63 Gene

mRNA/cDNA for TRIM63 Gene

(30) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM63 Gene

Tripartite motif containing 63, E3 ubiquitin protein ligase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM63 Gene

No ASD Table

Relevant External Links for TRIM63 Gene

GeneLoc Exon Structure for
TRIM63
ECgene alternative splicing isoforms for
TRIM63

Expression for TRIM63 Gene

mRNA expression in normal human tissues for TRIM63 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM63 Gene

This gene is overexpressed in Muscle - Skeletal (42.8) and Heart - Left Ventricle (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRIM63 Gene

SOURCE GeneReport for Unigene cluster for TRIM63 Gene Hs.279709

mRNA Expression by UniProt/SwissProt for TRIM63 Gene

Q969Q1-TRI63_HUMAN
Tissue specificity: Muscle specific. Selectively expressed in heart and skeletal muscle. Also expressed in the iris.
genes like me logo Genes that share expressions with TRIM63: view

Orthologs for TRIM63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM63 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM63 35
  • 99.62 (n)
  • 99.72 (a)
TRIM63 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM63 35
  • 91.54 (n)
  • 93.27 (a)
TRIM63 36
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM63 35
  • 90.72 (n)
  • 93.58 (a)
TRIM63 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim63 35
  • 88.18 (n)
  • 93.58 (a)
Trim63 16
Trim63 36
  • 92 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM63 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM63 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim63 35
  • 87.16 (n)
  • 92.35 (a)
chicken
(Gallus gallus)
Aves TRIM63 35
  • 77.51 (n)
  • 76.69 (a)
TRIM63 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM63 36
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim63 35
  • 67.81 (n)
  • 68.54 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6549 35
zebrafish
(Danio rerio)
Actinopterygii trim54 36
  • 43 (a)
ManyToMany
zgc56376 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for TRIM63:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM63 Gene

ENSEMBL:
Gene Tree for TRIM63 (if available)
TreeFam:
Gene Tree for TRIM63 (if available)

Paralogs for TRIM63 Gene

Selected SIMAP similar genes for TRIM63 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM63: view

Variants for TRIM63 Gene

Sequence variations from dbSNP and Humsavar for TRIM63 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1135251 -- 26,051,511(-) TGGTC(A/G)TTGGG utr-variant-3-prime
rs1135253 -- 26,051,389(-) CAGTG(C/T)CTATC utr-variant-3-prime
rs1317428 -- 26,057,127(-) AGCCC(C/G)ATGGG intron-variant
rs1317709 -- 26,058,199(-) ATGAT(A/C)AGATA intron-variant
rs1892495 -- 26,068,238(-) TTGCG(A/C/T)GGGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM63 Gene

Variant ID Type Subtype PubMed ID
nsv834513 CNV Gain 17160897
nsv871353 CNV Loss 21882294
nsv508678 CNV Loss 20534489

Relevant External Links for TRIM63 Gene

HapMap Linkage Disequilibrium report
TRIM63
Human Gene Mutation Database (HGMD)
TRIM63

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM63 Gene

Disorders for TRIM63 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM63 Gene including...

Search for TRIM63 Gene in MalaCards »

(3) University of Copenhagen DISEASES for TRIM63 Gene

(5) Novoseek inferred disease relationships for TRIM63 Gene

Disease -log(P) Hits PubMed IDs
virus infection 51.7 6
atrophy 43.7 11
kaposi sarcoma 30.1 2
hypertrophy 0 2
tumors 0 2
genes like me logo Genes that share disorders with TRIM63: view

No data available for UniProtKB/Swiss-Prot for TRIM63 Gene

Publications for TRIM63 Gene

  1. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PMID: 11927605) McElhinny A.S. … Gregorio C.C. (J. Cell Biol. 2002) 3 4 23
  2. MuRF1-dependent regulation of systemic carbohydrate metabolism as revealed from transgenic mouse studies. (PMID: 18468620) Hirner S. … Labeit D. (J. Mol. Biol. 2008) 3 4 23
  3. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 3 4
  4. A novel human striated muscle RING zinc finger protein, SMRZ, interacts with SMT3b via its RING domain. (PMID: 11283016) Dai K.-S. … Liew C.-C. (J. Biol. Chem. 2001) 2 3 4
  5. Identification of ubiquitin ligases required for skeletal muscle atrophy. (PMID: 11679633) Bodine S.C. … Glass D.J. (Science 2001) 3 4

Products for TRIM63 Gene

Sources for TRIM63 Gene

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