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Aliases for TRIM62 Gene

Aliases for TRIM62 Gene

  • Tripartite Motif Containing 62 2 3
  • Ductal Epithelium-Associated RING Chromosome 1 2 3
  • Tripartite Motif-Containing Protein 62 3 4
  • Tripartite Motif-Containing 62 2 3
  • E3 Ubiquitin-Protein Ligase TRIM62 3
  • EC 6.3.2.- 4
  • DEAR1 3

External Ids for TRIM62 Gene

Previous GeneCards Identifiers for TRIM62 Gene

  • GC01M033281
  • GC01M033383
  • GC01M033611
  • GC01M031726

Summaries for TRIM62 Gene

GeneCards Summary for TRIM62 Gene

TRIM62 (Tripartite Motif Containing 62) is a Protein Coding gene. Diseases associated with TRIM62 include ring chromosome 1. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM62 Gene

  • E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM62 Gene

Genomics for TRIM62 Gene

Regulatory Elements for TRIM62 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM62 Gene

Start:
33,145,399 bp from pter
End:
33,182,070 bp from pter
Size:
36,672 bases
Orientation:
Minus strand

Genomic View for TRIM62 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM62 Gene

Proteins for TRIM62 Gene

  • Protein details for TRIM62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVG3-TRI62_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM62
    Protein Accession:
    Q9BVG3
    Secondary Accessions:
    • B3KVH5
    • B4DTE4
    • D3DPR1
    • Q9NVG0

    Protein attributes for TRIM62 Gene

    Size:
    475 amino acids
    Molecular mass:
    54268 Da
    Quaternary structure:
    • Interacts with the ubiquitin-conjugating enzyme, UBE2D2.

    Alternative splice isoforms for TRIM62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM62 Gene

Proteomics data for TRIM62 Gene at MOPED

Post-translational modifications for TRIM62 Gene

Other Protein References for TRIM62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM62 Gene

Domains for TRIM62 Gene

Gene Families for TRIM62 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry

Q9BVG3

UniProtKB/Swiss-Prot:

TRI62_HUMAN :
  • Q9BVG3
Domain:
  • The RING finger is required for ubiquitin ligase activity
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM62: view

Function for TRIM62 Gene

Molecular function for TRIM62 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

Enzyme Numbers (IUBMB) for TRIM62 Gene

Gene Ontology (GO) - Molecular Function for TRIM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23402750
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM62: view

Phenotypes for TRIM62 Gene

GenomeRNAi human phenotypes for TRIM62:
genes like me logo Genes that share phenotypes with TRIM62: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM62 Gene

Localization for TRIM62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM62 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM62 Gene COMPARTMENTS Subcellular localization image for TRIM62 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 23402750
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM62: view

Pathways for TRIM62 Gene

SuperPathways for TRIM62 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

UniProtKB/Swiss-Prot Q9BVG3-TRI62_HUMAN

  • Pathway: Protein modification; protein ubiquitination

Interacting Proteins for TRIM62 Gene

Gene Ontology (GO) - Biological Process for TRIM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0019221 cytokine-mediated signaling pathway TAS --
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA 23077300
GO:0045087 innate immune response IMP 18248090
genes like me logo Genes that share ontologies with TRIM62: view

No data available for Pathways by source for TRIM62 Gene

Transcripts for TRIM62 Gene

Unigene Clusters for TRIM62 Gene

Tripartite motif containing 62:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM62

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM62 Gene

No ASD Table

Relevant External Links for TRIM62 Gene

GeneLoc Exon Structure for
TRIM62
ECgene alternative splicing isoforms for
TRIM62

Expression for TRIM62 Gene

mRNA expression in normal human tissues for TRIM62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM62 Gene

SOURCE GeneReport for Unigene cluster for TRIM62 Gene Hs.656006

genes like me logo Genes that share expressions with TRIM62: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM62 Gene

Orthologs for TRIM62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM62 35
  • 99.09 (n)
  • 99.37 (a)
TRIM62 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM62 35
  • 92.56 (n)
  • 99.16 (a)
TRIM62 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM62 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim62 35
  • 90.95 (n)
  • 99.16 (a)
Trim62 16
Trim62 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM62 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM62 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim62 35
  • 91.37 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves TRIM62 35
  • 85.54 (n)
  • 89.89 (a)
TRIM62 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM62 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12886 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13161 35
zebrafish
(Danio rerio)
Actinopterygii Dr.27470 35
trim62 35
  • 75.09 (n)
  • 81.26 (a)
trim62 36
  • 81 (a)
OneToMany
TRIM62 (2 of 2) 36
  • 84 (a)
OneToMany
Species with no ortholog for TRIM62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM62 Gene

ENSEMBL:
Gene Tree for TRIM62 (if available)
TreeFam:
Gene Tree for TRIM62 (if available)

Paralogs for TRIM62 Gene

Selected SIMAP similar genes for TRIM62 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM62: view

Variants for TRIM62 Gene

Sequence variations from dbSNP and Humsavar for TRIM62 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs584298 -- 33,171,056(+) AAGAG(A/G)CTGCA intron-variant
rs587042 -- 33,173,135(+) AGAAC(C/T)GGATG intron-variant
rs587910 -- 33,177,760(+) acaac(A/G)gttat intron-variant
rs591359 -- 33,183,626(+) gtgac(A/G)gtttg upstream-variant-2KB
rs591664 -- 33,163,640(+) GGAGG(C/T)GCTGG intron-variant, downstream-variant-500B

Relevant External Links for TRIM62 Gene

HapMap Linkage Disequilibrium report
TRIM62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM62 Gene

Disorders for TRIM62 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM62 Gene including...

Search for TRIM62 Gene in MalaCards »

Relevant External Links for TRIM62

Genetic Association Database (GAD)
TRIM62
Human Genome Epidemiology (HuGE) Navigator
TRIM62
genes like me logo Genes that share disorders with TRIM62: view

No data available for UniProtKB/Swiss-Prot for TRIM62 Gene

Publications for TRIM62 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  4. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. (PMID: 19536326) Lott S.T. … Killary A.M. (PLoS Med. 2009) 2 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48

Products for TRIM62 Gene

Sources for TRIM62 Gene

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