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Aliases for TRIM62 Gene

Aliases for TRIM62 Gene

  • Tripartite Motif Containing 62 2 3 5
  • Ductal Epithelium-Associated RING Chromosome 1 2 3
  • Tripartite Motif-Containing Protein 62 3 4
  • Tripartite Motif-Containing 62 2 3
  • EC 6.3.2.- 4
  • DEAR1 3

External Ids for TRIM62 Gene

Previous GeneCards Identifiers for TRIM62 Gene

  • GC01M033281
  • GC01M033383
  • GC01M033611
  • GC01M031726

Summaries for TRIM62 Gene

GeneCards Summary for TRIM62 Gene

TRIM62 (Tripartite Motif Containing 62) is a Protein Coding gene. Diseases associated with TRIM62 include ring chromosome 1. Among its related pathways are Immune System and Interferon gamma signaling. GO annotations related to this gene include ligase activity and ubiquitin-protein transferase activity. An important paralog of this gene is TRIM50.

UniProtKB/Swiss-Prot for TRIM62 Gene

  • E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM62 Gene

Genomics for TRIM62 Gene

Regulatory Elements for TRIM62 Gene

Promoters for TRIM62 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM62 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM62 Gene

Chromosome:
1
Start:
33,145,399 bp from pter
End:
33,182,070 bp from pter
Size:
36,672 bases
Orientation:
Minus strand

Genomic View for TRIM62 Gene

Genes around TRIM62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM62 Gene

Proteins for TRIM62 Gene

  • Protein details for TRIM62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BVG3-TRI62_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM62
    Protein Accession:
    Q9BVG3
    Secondary Accessions:
    • B3KVH5
    • B4DTE4
    • D3DPR1
    • Q9NVG0

    Protein attributes for TRIM62 Gene

    Size:
    475 amino acids
    Molecular mass:
    54268 Da
    Quaternary structure:
    • Interacts with the ubiquitin-conjugating enzyme, UBE2D2.

    Alternative splice isoforms for TRIM62 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM62 Gene

Proteomics data for TRIM62 Gene at MOPED

Post-translational modifications for TRIM62 Gene

Other Protein References for TRIM62 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM62 Gene

Domains & Families for TRIM62 Gene

Gene Families for TRIM62 Gene

Graphical View of Domain Structure for InterPro Entry

Q9BVG3

UniProtKB/Swiss-Prot:

TRI62_HUMAN :
  • The RING finger is required for ubiquitin ligase activity.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The RING finger is required for ubiquitin ligase activity.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM62: view

Function for TRIM62 Gene

Molecular function for TRIM62 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

Enzyme Numbers (IUBMB) for TRIM62 Gene

Gene Ontology (GO) - Molecular Function for TRIM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA 23402750
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM62: view
genes like me logo Genes that share phenotypes with TRIM62: view

Animal Models for TRIM62 Gene

MGI Knock Outs for TRIM62:

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM62

miRNA for TRIM62 Gene

miRTarBase miRNAs that target TRIM62

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM62 Gene

Localization for TRIM62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM62 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM62 Gene COMPARTMENTS Subcellular localization image for TRIM62 gene
Compartment Confidence
cytosol 5
nucleus 3

No data available for Gene Ontology (GO) - Cellular Components for TRIM62 Gene

Pathways & Interactions for TRIM62 Gene

genes like me logo Genes that share pathways with TRIM62: view

Pathways by source for TRIM62 Gene

UniProtKB/Swiss-Prot Q9BVG3-TRI62_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Interacting Proteins for TRIM62 Gene

Gene Ontology (GO) - Biological Process for TRIM62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032897 negative regulation of viral transcription IDA 18248090
GO:0045087 innate immune response IMP 18248090
GO:0046596 regulation of viral entry into host cell IDA 18248090
GO:0051092 positive regulation of NF-kappaB transcription factor activity IMP 23077300
GO:0060333 interferon-gamma-mediated signaling pathway TAS --
genes like me logo Genes that share ontologies with TRIM62: view

No data available for SIGNOR curated interactions for TRIM62 Gene

Drugs & Compounds for TRIM62 Gene

No Compound Related Data Available

Transcripts for TRIM62 Gene

Unigene Clusters for TRIM62 Gene

Tripartite motif containing 62:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM62 Gene

No ASD Table

Relevant External Links for TRIM62 Gene

GeneLoc Exon Structure for
TRIM62
ECgene alternative splicing isoforms for
TRIM62

Expression for TRIM62 Gene

mRNA expression in normal human tissues for TRIM62 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM62 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM62 Gene



SOURCE GeneReport for Unigene cluster for TRIM62 Gene Hs.656006

genes like me logo Genes that share expression patterns with TRIM62: view

Protein tissue co-expression partners for TRIM62 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TRIM62 Gene

Orthologs for TRIM62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM62 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM62 35
  • 99.09 (n)
  • 99.37 (a)
TRIM62 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM62 36
  • 99 (a)
OneToOne
TRIM62 35
  • 92.56 (n)
  • 99.16 (a)
dog
(Canis familiaris)
Mammalia TRIM62 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim62 36
  • 99 (a)
OneToOne
Trim62 16
Trim62 35
  • 90.95 (n)
  • 99.16 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM62 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM62 36
  • 94 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim62 35
  • 91.37 (n)
  • 98.95 (a)
chicken
(Gallus gallus)
Aves TRIM62 36
  • 89 (a)
OneToOne
TRIM62 35
  • 85.54 (n)
  • 89.89 (a)
lizard
(Anolis carolinensis)
Reptilia TRIM62 36
  • 84 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.12886 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13161 35
zebrafish
(Danio rerio)
Actinopterygii trim62 36
  • 81 (a)
OneToMany
TRIM62 (2 of 2) 36
  • 84 (a)
OneToMany
Dr.27470 35
trim62 35
  • 75.09 (n)
  • 81.26 (a)
Species with no ortholog for TRIM62:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM62 Gene

ENSEMBL:
Gene Tree for TRIM62 (if available)
TreeFam:
Gene Tree for TRIM62 (if available)

Paralogs for TRIM62 Gene

Paralogs for TRIM62 Gene

(10) SIMAP similar genes for TRIM62 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM62: view

Variants for TRIM62 Gene

Sequence variations from dbSNP and Humsavar for TRIM62 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs635677 -- 33,180,544(+) GATCC(A/G)GTCTC intron-variant
rs622407 -- 33,181,349(+) AAGTA(A/G)TGCTC reference, synonymous-codon
rs2935998 -- 33,183,642(-) TCAGG(C/G)TGGAC upstream-variant-2KB
rs2935999 -- 33,180,043(-) atcct(C/T)tccgt intron-variant
rs3753601 -- 33,182,377(+) CGAAC(A/T)AGAAT upstream-variant-2KB

Variation tolerance for TRIM62 Gene

Residual Variation Intolerance Score: 37.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.53; 55.64% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM62 Gene

HapMap Linkage Disequilibrium report
TRIM62

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM62 Gene

Disorders for TRIM62 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM62 Gene - From: GeneCards

Disorder Aliases PubMed IDs
ring chromosome 1
  • chromosome 1 ring
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM62

Genetic Association Database (GAD)
TRIM62
Human Genome Epidemiology (HuGE) Navigator
TRIM62
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM62
genes like me logo Genes that share disorders with TRIM62: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM62 Gene

Publications for TRIM62 Gene

  1. Characterization of TRIM62 as a RING finger E3 ubiquitin ligase and its subcellular localization. (PMID: 23402750) Huang F. … Yang R.G. (Biochem. Biophys. Res. Commun. 2013) 3 4 67
  2. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. (PMID: 19536326) Lott S.T. … Killary A.M. (PLoS Med. 2009) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity. (PMID: 25261235) Chen N. … Killary A.M. (Cancer Res. 2014) 3
  5. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 3

Products for TRIM62 Gene

Sources for TRIM62 Gene

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