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Aliases for TRIM61 Gene

Aliases for TRIM61 Gene

  • Tripartite Motif Containing 61 2 3
  • Tripartite Motif-Containing 61 2 3
  • Ring Finger Protein 35 2 3
  • RNF35 3 4
  • Putative Tripartite Motif-Containing Protein 61 3
  • RING Finger Protein 35 4

External Ids for TRIM61 Gene

Previous Symbols for TRIM61 Gene

  • RNF35

Summaries for TRIM61 Gene

GeneCards Summary for TRIM61 Gene

TRIM61 (Tripartite Motif Containing 61) is a Protein Coding gene. An important paralog of this gene is TRIM77.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM61 Gene

Genomics for TRIM61 Gene

Genomic Location for TRIM61 Gene

164,954,446 bp from pter
164,977,668 bp from pter
23,223 bases
Minus strand

Genomic View for TRIM61 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM61 Gene

Regulatory Elements for TRIM61 Gene

Proteins for TRIM61 Gene

  • Protein details for TRIM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tripartite motif-containing protein 61
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TRIM61 Gene

    209 amino acids
    Molecular mass:
    24047 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM61 Gene

Proteomics data for TRIM61 Gene at MOPED

Post-translational modifications for TRIM61 Gene

No Post-translational modifications

Other Protein References for TRIM61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM61 Gene

Domains for TRIM61 Gene

Gene Families for TRIM61 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM61 Gene

Suggested Antigen Peptide Sequences for TRIM61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B box-type zinc finger.:
    • Q5EBN2
  • Contains 1 RING-type zinc finger.:
    • Q5EBN2
genes like me logo Genes that share domains with TRIM61: view

Function for TRIM61 Gene

Gene Ontology (GO) - Molecular Function for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM61: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM61 Gene

Localization for TRIM61 Gene

Subcellular locations from

Jensen Localization Image for TRIM61 Gene COMPARTMENTS Subcellular localization image for TRIM61 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM61: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM61 Gene

Pathways for TRIM61 Gene

SuperPathways for TRIM61 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM61 Gene


No data available for Pathways by source for TRIM61 Gene

Transcripts for TRIM61 Gene

mRNA/cDNA for TRIM61 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM61 Gene

Tripartite motif containing 61:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM61 Gene

No ASD Table

Relevant External Links for TRIM61 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM61 Gene

mRNA expression in normal human tissues for TRIM61 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM61 Gene

This gene is overexpressed in Testis (7.1).

SOURCE GeneReport for Unigene cluster for TRIM61 Gene Hs.654633

genes like me logo Genes that share expressions with TRIM61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TRIM61 Gene

Orthologs for TRIM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM61 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
-- 36
  • 99 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 15 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 23 (a)
-- 36
  • 31 (a)
-- 36
  • 12 (a)
-- 36
  • 12 (a)
-- 36
  • 15 (a)
-- 36
  • 16 (a)
-- 36
  • 22 (a)
(Danio rerio)
Actinopterygii trim109 36
  • 8 (a)
Species with no ortholog for TRIM61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM61 Gene

Gene Tree for TRIM61 (if available)
Gene Tree for TRIM61 (if available)

Paralogs for TRIM61 Gene

Selected SIMAP similar genes for TRIM61 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM61: view

Variants for TRIM61 Gene

Sequence variations from dbSNP and Humsavar for TRIM61 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs939085 -- 164,970,472(-) gaatc(G/T)ctgca intron-variant
rs1814924 -- 164,965,619(+) tagta(A/G)agatg intron-variant
rs1878922 -- 164,968,863(-) CCAAT(A/T)TTAGT intron-variant, synonymous-codon, reference
rs1878923 -- 164,968,671(-) GATAA(C/T)TTTAC intron-variant, synonymous-codon, reference
rs1878924 -- 164,968,532(-) TGAAT(A/C)TAGTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM61 Gene

Variant ID Type Subtype PubMed ID
nsv880382 CNV Gain 21882294
dgv1711e1 CNV Complex 17122850
nsv528686 CNV Gain 19592680
nsv830140 CNV Loss 17160897
nsv517554 CNV Loss 19592680
esv21636 CNV Gain 19812545
nsv10607 CNV Gain 18304495
esv2421831 CNV Duplication 20811451

Relevant External Links for TRIM61 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM61 Gene

Disorders for TRIM61 Gene

(1) University of Copenhagen DISEASES for TRIM61 Gene

Relevant External Links for TRIM61

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TRIM61: view

No data available for UniProtKB/Swiss-Prot for TRIM61 Gene

Publications for TRIM61 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (PMID: 15994318) Huang C.J. … Choo K.B. (J. Biol. Chem. 2005) 3
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3

Products for TRIM61 Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM61
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM61
    • Block miRNA regulation of TRIM61 using miScript Target Protectors

    Sources for TRIM61 Gene

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