Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM61 Gene

Aliases for TRIM61 Gene

  • Tripartite Motif Containing 61 2 3 5
  • RING Finger Protein 35 2 3 4
  • RNF35 3 4
  • Putative Tripartite Motif-Containing Protein 61 3
  • Tripartite Motif-Containing 61 2

External Ids for TRIM61 Gene

Previous HGNC Symbols for TRIM61 Gene

  • RNF35

Previous GeneCards Identifiers for TRIM61 Gene

  • GC04M166247
  • GC04M166095
  • GC04M165875
  • GC04M161629

Summaries for TRIM61 Gene

GeneCards Summary for TRIM61 Gene

TRIM61 (Tripartite Motif Containing 61) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM61 Gene

Genomics for TRIM61 Gene

Regulatory Elements for TRIM61 Gene

Enhancers for TRIM61 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04F164948 0.2 Ensembl 11.5 +29.6 29568 0.2 TRIM61 LOC391711 FAM218A
GH04F164798 0.6 ENCODE 10.8 +177.9 177875 2.3 TEAD4 MAX POU5F1 TRIM61 RNU6-668P APELA
GH04F164801 0.9 ENCODE 10.8 +175.9 175910 0.2 RAD21 YY1 TRIM61 RNU6-668P APELA
GH04F164926 0.6 ENCODE 10.7 +51.2 51165 0.2 TRIM61 GC04M164931 RPL26P16
GH04F164931 0.2 ENCODE 7.6 +45.5 45524 1.7 TRIM60P14 TRIM61 FAM218BP ENSG00000270960
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM61 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM61 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001253578 267 1599 CTCF MAZ SMAD5 NRF1 CBFB RAD21 ZBTB40 GABPA POLR2A ELK1

Genomic Location for TRIM61 Gene

Chromosome:
4
Start:
164,954,446 bp from pter
End:
164,977,668 bp from pter
Size:
23,223 bases
Orientation:
Minus strand

Genomic View for TRIM61 Gene

Genes around TRIM61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM61 Gene

Proteins for TRIM61 Gene

  • Protein details for TRIM61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5EBN2-TRI61_HUMAN
    Recommended name:
    Putative tripartite motif-containing protein 61
    Protein Accession:
    Q5EBN2

    Protein attributes for TRIM61 Gene

    Size:
    209 amino acids
    Molecular mass:
    24047 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM61 Gene

Post-translational modifications for TRIM61 Gene

No Post-translational modifications

Other Protein References for TRIM61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM61 Gene

Domains & Families for TRIM61 Gene

Gene Families for TRIM61 Gene

Protein Domains for TRIM61 Gene

Suggested Antigen Peptide Sequences for TRIM61 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5EBN2

UniProtKB/Swiss-Prot:

TRI61_HUMAN :
  • Contains 1 B box-type zinc finger.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM61: view

Function for TRIM61 Gene

Gene Ontology (GO) - Molecular Function for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM61: view

Phenotypes for TRIM61 Gene

GenomeRNAi human phenotypes for TRIM61:
genes like me logo Genes that share phenotypes with TRIM61: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM61 Gene

Localization for TRIM61 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM61 Gene COMPARTMENTS Subcellular localization image for TRIM61 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM61: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM61 Gene

Pathways & Interactions for TRIM61 Gene

SuperPathways for TRIM61 Gene

No Data Available

Interacting Proteins for TRIM61 Gene

Gene Ontology (GO) - Biological Process for TRIM61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM61 Gene

Transcripts for TRIM61 Gene

mRNA/cDNA for TRIM61 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(28) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM61 Gene

Tripartite motif containing 61:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM61 Gene

No ASD Table

Relevant External Links for TRIM61 Gene

GeneLoc Exon Structure for
TRIM61
ECgene alternative splicing isoforms for
TRIM61

Expression for TRIM61 Gene

mRNA expression in normal human tissues for TRIM61 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM61 Gene

This gene is overexpressed in Testis (x7.1).

NURSA nuclear receptor signaling pathways regulating expression of TRIM61 Gene:

TRIM61

SOURCE GeneReport for Unigene cluster for TRIM61 Gene:

Hs.654633
genes like me logo Genes that share expression patterns with TRIM61: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM61 Gene

Orthologs for TRIM61 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
OneToMany
-- 35
  • 99 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 15 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 22 (a)
ManyToMany
-- 35
  • 16 (a)
ManyToMany
-- 35
  • 15 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
-- 35
  • 12 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 35
  • 8 (a)
ManyToMany
Species where no ortholog for TRIM61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM61 Gene

ENSEMBL:
Gene Tree for TRIM61 (if available)
TreeFam:
Gene Tree for TRIM61 (if available)

Paralogs for TRIM61 Gene

(17) SIMAP similar genes for TRIM61 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM61: view

No data available for Paralogs for TRIM61 Gene

Variants for TRIM61 Gene

Sequence variations from dbSNP and Humsavar for TRIM61 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs10001548 -- 164,958,229(+) AGCTA(C/T)AGAAA intron-variant, utr-variant-3-prime
rs10004751 -- 164,968,219(+) TCCAA(C/G)AGTAA intron-variant
rs10007789 -- 164,969,225(+) ATTCT(C/T)ATATC intron-variant
rs10034083 -- 164,957,855(+) TAAGG(A/G)TATGT intron-variant, utr-variant-3-prime
rs10517825 -- 164,972,334(-) TGGTC(A/G)AGAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM61 Gene

Variant ID Type Subtype PubMed ID
esv21636 CNV gain 19812545
esv2421831 CNV duplication 20811451
esv2759299 CNV gain 17122850
esv2760876 CNV gain 21179565
esv3603011 CNV gain 21293372
nsv1019150 CNV gain 25217958
nsv10607 CNV gain 18304495
nsv517554 CNV loss 19592680
nsv528686 CNV gain 19592680
nsv830140 CNV loss 17160897
nsv967808 CNV duplication 23825009

Variation tolerance for TRIM61 Gene

Residual Variation Intolerance Score: 64.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.64; 45.51% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM61 Gene

Disorders for TRIM61 Gene

Relevant External Links for TRIM61

Genetic Association Database (GAD)
TRIM61
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM61

No disorders were found for TRIM61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM61 Gene

Publications for TRIM61 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  3. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (PMID: 15994318) Huang C.J. … Choo K.B. (J. Biol. Chem. 2005) 3 64
  4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PMID: 15146197) Brandenberger R. … Stanton L.W. (Nat. Biotechnol. 2004) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TRIM61 Gene

Sources for TRIM61 Gene

Content
Loading form....