TRIM61 Gene
protein-coding GIFtS: 41
GCID: GC04M165875
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tripartite motif containing 61(Previous names: ring finger protein 35, tripartite motif-containing 61...)
(Previous symbol: RNF35)
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Aliases
for TRIM61 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 611 2 | | RING Finger Protein 351 2 3 | | RNF351 2 3 | | Tripartite Motif-Containing 611 2 | | Putative Tripartite Motif-Containing Protein 612 |
Export aliases for TRIM61 gene to outside databasesPrevious GC identifers: GC04M166247 GC04M166095 GC04M161629 |
Summaries
for TRIM61 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM61 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM61 gene promoter:
GR-beta LUN-1 GATA-1 NF-AT NF-AT4 NF-AT2 STAT3 NF-AT3 GR-alpha NF-AT1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM61
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM61 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3TRIM61 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04M165875: view genomic region
(about GC identifiers)
Start:
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165,875,598 bp from pter |
End:
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165,898,820 bp from pter |
Size:
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23,223 bases |
Orientation:
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minus strand |
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Proteins
for TRIM61 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI61_HUMAN, Q5EBN2 (See
protein sequence)Recommended Name: Putative tripartite motif-containing protein 61 Size: 209 amino acids; 24047 DaExplore the universe of human proteins at neXtProt for TRIM61: NX_Q5EBN2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5EBN2
TRIM61 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001012414.1
ENSEMBL proteins: ENSP00000332288
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM61 for ontologies About GeneDecksing
TRIM61 Antibody Products:
Assay Products for TRIM61: |
Protein
Domains /
Families
for TRIM61 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM61 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5EBN2ProtoNet protein and cluster: Q5EBN2 1 Blocks protein family: IPB000315 B-box zinc finger signature
UniProtKB/Swiss-Prot: TRI61_HUMAN, Q5EBN2Similarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM61 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM61 (NM_001012414) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM61 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM61 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM61 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM61 for ontologies About GeneDecksing
|
Pathways & Interactions
for TRIM61 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM61
|
Drugs & Compounds
for TRIM61 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM61
Search CenterWatch for drugs/clinical trials and news about TRIM61 / TRI61
|
Transcripts
for TRIM61 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM61 gene: NM_001012414.2 Unigene Cluster for TRIM61: Tripartite motif containing 61 Hs.654633 [show with all ESTs]Unigene Representative Sequence: AK2961001 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000329314(uc003iqw.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM61 (NM_001012414) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM61 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM61 |
Additional cDNA sequence: AK296100.1 BC089393.1 5 DOTS entries: DT.92037044 DT.40309116 DT.40276320 DT.95359241 DT.121258957 24/28 AceView cDNA sequences (see all 28): AA758637 BU624683 BX109294 BF508746 BF509253 BE673692 BG720346 BE504533 BU506695 BX117694 BV171827 BU852365 BQ432559 AA903505 AA256091 CD244312 BU192611 AW968087 BU852387 AV699295 AI768020 AI763262 AI312070 M78451
GeneLoc Exon Structure
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Expression
for TRIM61 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM61 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTGTAAGAA
About this image
See TRIM61 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM61
SOURCE GeneReport for Unigene cluster: Hs.654633
SABiosciences Expression via Pathway-Focused PCR Array including TRIM61: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM61
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM61 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM61 |
Orthologs
for TRIM61 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM61 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
10(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM61 (if available)
TreeFam Gene Tree for TRIM61 (if available) |
Paralogs
for TRIM61 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TRIM61 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TRIM61
6 CNVs: 64011 51321 31203 3524 80551 80552
1 Indel: 51322 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM61 |
|
Disorders
/ Diseases
for TRIM61 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM61 for disorders About GeneDecksing
1  disease for TRIM61: About MalaCardspremature ovarian failure
1 disease from the University of Copenhagen DISEASES database for TRIM61:Premature ovarian failure Export disorders for TRIM61 gene to outside databases
|
Publications
for TRIM61 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM61 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM61) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (PubMed id 15994318)1 Huang C.J....Choo K.B. (2005)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TRIM61 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIM61 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM61 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM61 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM61 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM61 gene:
Search GeneIP for patents involving TRIM61
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM61 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM61 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM61 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM61 | | | OriGene Protein Over-expression Lysate for TRIM61 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM61 | | OriGene 3'-UTR Clone for TRIM61 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM61 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM61 | | OriGene Custom Protein Services for TRIM61 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM61 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM61 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM61 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM61 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM61 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM61 |
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| | | | Search Tocris compounds for TRIM61 |
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 | | | TRIM61 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM61 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM61 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM61 |
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