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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM61 Gene

protein-coding   GIFtS: 41
GCID: GC04M165875

Tripartite Motif Containing 61

(Previous names: ring finger protein 35, tripartite motif-containing 61)
(Previous symbol: RNF35)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Tripartite Motif Containing 611 2
RING Finger Protein 351 2 3
RNF351 2 3
Tripartite Motif-Containing 611 2
Putative Tripartite Motif-Containing Protein 612

External Ids:    HGNC: 243391   Entrez Gene: 3917122   Ensembl: ENSG000001834397   UniProtKB: Q5EBN23   

Export aliases for TRIM61 gene to outside databases

Previous GC identifers: GC04M166247 GC04M166095 GC04M161629


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TRIM61 Gene: 
TRIM61 (tripartite motif containing 61) is a protein-coding gene. Diseases associated with TRIM61 include premature ovarian failure. GO annotations related to this gene include zinc ion binding. An important paralog of this gene is TRIM31.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000004.11  NT_016354.19  NC_018915.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM61 gene promoter:
         GR-beta   LUN-1   GATA-1   NF-AT   NF-AT4   NF-AT2   STAT3   NF-AT3   GR-alpha   NF-AT1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM61 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM61

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM61


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q32.3   Ensembl cytogenetic band:  4q32.3   HGNC cytogenetic band: 4q32.3

TRIM61 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM61 gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04M165875:  view genomic region     (about GC identifiers)

Start:
165,875,598 bp from pter      End:
165,898,820 bp from pter
Size:
23,223 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TRI61_HUMAN, Q5EBN2 (See protein sequence)
Recommended Name: Putative tripartite motif-containing protein 61  
Size: 209 amino acids; 24047 Da

Explore the universe of human proteins at neXtProt for TRIM61: NX_Q5EBN2

Explore proteomics data for TRIM61 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q5EBN2

  • TRIM61 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TRIM61 Protein Expression
    REFSEQ proteins: NP_001012414.1  
    ENSEMBL proteins: 
     ENSP00000332288  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    TRIM61 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000315 Znf_B-box
     IPR018957 Znf_C3HC4_RING-type
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q5EBN2

    ProtoNet protein and cluster: Q5EBN2

    1 Blocks protein domain: IPB000315 B-box zinc finger signature

    UniProtKB/Swiss-Prot: TRI61_HUMAN, Q5EBN2
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    TRIM61 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM61 for ontologies           About GeneDecksing


    Animal Models:
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM61

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM61 (TRI61)

    Search CenterWatch for drugs/clinical trials and news about TRIM61 / TRI61

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM61 gene: 
    NM_001012414.2  

    Unigene Cluster for TRIM61:

    Tripartite motif containing 61
    Hs.654633  [show with all ESTs]
    Unigene Representative Sequence: AK296100
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000329314(uc003iqw.3)
    miRNA
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    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TRIM61 (NM_001012414)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM61
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM61
    Sirion Biotech Customized lentivirus for stable overexpression of TRIM61 
                         Customized lentivirus expression plasmids for stable overexpression of TRIM61 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM61
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM61

    Additional mRNA sequence: 

    AK296100.1 BC089393.1 

    5 DOTS entries:

    DT.92037044  DT.40309116  DT.40276320  DT.95359241  DT.121258957 

    24/28 AceView cDNA sequences (see all 28):

    AA758637 BU624683 BX109294 BE673692 BV171827 BQ432559 BF508746 BX117694 
    AW968087 BF509253 BU192611 AA903505 BU506695 AA256091 BG720346 BU852365 
    BE504533 CD244312 AI312758 BV173490 M78451 BU852387 AI312070 AV699295 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM61 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTGTAAGAA
    TRIM61 Expression
    About this image


    See TRIM61 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM61

    SOURCE GeneReport for Unigene cluster: Hs.654633
        SABiosciences Expression via Pathway-Focused PCR Array including TRIM61: 
              Ubiquitin Ligases in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM61
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM61

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM61 gene from 2 species (see representative species )    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chimpanzee
    (Pan troglodytes)
    Mammalia --
    --
    --
    98(a)
    98(a)
    1 ↔ many
    1 ↔ many
    4(168030416-168030940)
    4(168023146-168023670)
    zebrafish
    (Danio rerio)
    Actinopterygii TRIM416
    tripartite motif containing 41
    8(a)
    1 → many
    7(25340848-25348868)


    ENSEMBL Gene Tree for TRIM61 (if available)
    TreeFam Gene Tree for TRIM61 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM61 gene
    TRIM312  TRIM502  TRIM522  TRIM732  TRIM352  TRIM692  TRIM742  TRIM622  
    TRIM412  TRIM722  
    17 SIMAP similar genes for TRIM61 using alignment to 1 protein entry:     TRI61_HUMAN:
    TRIM60    TRIM39    TRIM75    TRIM22    TRIM51    TRIM26
    TRIM49    TRIM49C    TRIM68    TRIM31    TRIM21    TRIM48
    TRIM50    TRIM64B    TRIM17    TRIM64    TRIM73

    TRIM61 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/423 SNPs in TRIM61 are shown (see all 423)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 4 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1506049161,2
    --165875111(+) TCCACC/TCAGTG 1 -- ds50010--------
    rs1925307681,2
    --165875177(+) ACCCCG/TGTCCC 1 -- ds50010--------
    rs768529341,2
    C,F--165875183(+) GTCCCC/TTTCAC 1 -- ds50011Minor allele frequency- T:0.05WA 118
    rs2002094851,2
    --165875276(+) TAAGG-/AAAAAA 1 -- ds50010--------
    rs1397945031,2
    --165875358(+) TGTTGA/CGTCTT 1 -- ds50010--------
    rs285442521,2
    C,F,H--165875359(+) GTTGCG/ATCTTC 1 -- ds500120Minor allele frequency- A:0.23NS EA NA WA CSA 2342
    rs1493690151,2
    --165875376(+) GGATCA/GACGAA 1 -- ds50010--------
    rs1447198021,2
    --165875379(+) TCGACA/GAAGAA 1 -- ds50010--------
    rs1142499431,2
    F--165875457(+) CTCCGC/TACCCT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs1845187451,2
    --165875474(+) ACCCTC/TTACTG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for TRIM61 (165875598 - 165898820 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for TRIM61:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2421831CNV Duplication20811451
    nsv517554CNV Loss19592680
    nsv830140CNV Loss17160897
    nsv528686CNV Gain19592680
    nsv10607CNV Gain18304495
    nsv880382CNV Gain21882294
    esv21636CNV Gain19812545
    dgv1711e1CNV Complex17122850

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for TRIM61:    About MalaCards
    premature ovarian failure    

    1 disease from the University of Copenhagen DISEASES database for TRIM61:
    Premature ovarian failure

    TRIM61 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM61

    Export disorders for TRIM61 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM61 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TRIM61)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    3. Negative transcriptional modulation and silencing of the bi-exonic Rnf35 gene in the preimplantation embryo. Binding of the CCAAT-displacement protein/Cux to the untranslated exon 1 sequence. (PubMed id 15994318)1 Huang C.J....Choo K.B. (2005)
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 391712 HGNC: 24339 AceView: LOC391712 Ensembl:ENSG00000183439 euGenes: HUgn391712
    ECgene: TRIM61 H-InvDB: TRIM61

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM61 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM61 gene:
    Search GeneIP for patents involving TRIM61

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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