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Aliases for TRIM60 Gene

Aliases for TRIM60 Gene

  • Tripartite Motif Containing 60 2 3 5
  • Tripartite Motif-Containing 60 2 3
  • Ring Finger Protein 129 2 3
  • RNF129 3 4
  • RNF33 3 4
  • RING Finger Protein 129 4
  • Ring Finger Protein 33 3
  • RING Finger Protein 33 4

External Ids for TRIM60 Gene

Previous HGNC Symbols for TRIM60 Gene

  • RNF129
  • RNF33

Previous GeneCards Identifiers for TRIM60 Gene

  • GC04P166311
  • GC04P166172
  • GC04P165953
  • GC04P161706

Summaries for TRIM60 Gene

Entrez Gene Summary for TRIM60 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRIM60 Gene

TRIM60 (Tripartite Motif Containing 60) is a Protein Coding gene. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM60 Gene

Genomics for TRIM60 Gene

Regulatory Elements for TRIM60 Gene

Enhancers for TRIM60 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM60 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM60 Gene

Chromosome:
4
Start:
165,025,762 bp from pter
End:
165,041,818 bp from pter
Size:
16,057 bases
Orientation:
Plus strand

Genomic View for TRIM60 Gene

Genes around TRIM60 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM60 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM60 Gene

Proteins for TRIM60 Gene

  • Protein details for TRIM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495X7-TRI60_HUMAN
    Recommended name:
    Tripartite motif-containing protein 60
    Protein Accession:
    Q495X7
    Secondary Accessions:
    • Q8NA35

    Protein attributes for TRIM60 Gene

    Size:
    471 amino acids
    Molecular mass:
    55114 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM60 Gene

Proteomics data for TRIM60 Gene at MOPED

Post-translational modifications for TRIM60 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM60 Gene

No data available for DME Specific Peptides for TRIM60 Gene

Domains & Families for TRIM60 Gene

Gene Families for TRIM60 Gene

Suggested Antigen Peptide Sequences for TRIM60 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q495X7

UniProtKB/Swiss-Prot:

TRI60_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM60: view

Function for TRIM60 Gene

genes like me logo Genes that share phenotypes with TRIM60: view

Animal Model Products

miRNA for TRIM60 Gene

miRTarBase miRNAs that target TRIM60

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM60 Gene

Localization for TRIM60 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM60 Gene COMPARTMENTS Subcellular localization image for TRIM60 gene
Compartment Confidence
nucleus 3

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM60 Gene

Pathways & Interactions for TRIM60 Gene

SuperPathways for TRIM60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM60 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM60 Gene

Drugs & Compounds for TRIM60 Gene

No Compound Related Data Available

Transcripts for TRIM60 Gene

mRNA/cDNA for TRIM60 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM60 Gene

Tripartite motif containing 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM60 Gene

No ASD Table

Relevant External Links for TRIM60 Gene

GeneLoc Exon Structure for
TRIM60
ECgene alternative splicing isoforms for
TRIM60

Expression for TRIM60 Gene

mRNA expression in normal human tissues for TRIM60 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM60 Gene

This gene is overexpressed in Testis (x51.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM60 Gene



SOURCE GeneReport for Unigene cluster for TRIM60 Gene Hs.368004

genes like me logo Genes that share expression patterns with TRIM60: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM60 Gene

Orthologs for TRIM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM60 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRIM61 35
  • 79.02 (n)
  • 70.18 (a)
mouse
(Mus musculus)
Mammalia Trim60 35
  • 67.84 (n)
  • 53.96 (a)
Trim60 16
Trim60 36
  • 52 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM60 35
  • 98.73 (n)
  • 97.66 (a)
TRIM60 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM60 36
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM7.2 36
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 29 (a)
ManyToMany
Species with no ortholog for TRIM60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM60 Gene

ENSEMBL:
Gene Tree for TRIM60 (if available)
TreeFam:
Gene Tree for TRIM60 (if available)

Paralogs for TRIM60 Gene

genes like me logo Genes that share paralogs with TRIM60: view

Variants for TRIM60 Gene

Sequence variations from dbSNP and Humsavar for TRIM60 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs950268 -- 165,040,697(-) CATCT(A/C)TTCAT reference, stop-gained
rs2056252 -- 165,026,338(-) CAGGC(C/T)TGGcg intron-variant
rs4133108 -- 165,031,283(-) AGACA(C/G)TGAAA intron-variant, upstream-variant-2KB
rs4133109 -- 165,031,206(-) tgaga(C/T)ggagt intron-variant, upstream-variant-2KB
rs4690800 -- 165,030,838(+) GATCC(A/G)CCCGC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM60 Gene

Variant ID Type Subtype PubMed ID
nsv880382 CNV Gain 21882294
dgv1711e1 CNV Complex 17122850
nsv830140 CNV Loss 17160897
esv2728685 CNV Deletion 23290073

Variation tolerance for TRIM60 Gene

Residual Variation Intolerance Score: 48.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.77; 33.48% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM60 Gene

Disorders for TRIM60 Gene

Relevant External Links for TRIM60

Genetic Association Database (GAD)
TRIM60
Human Genome Epidemiology (HuGE) Navigator
TRIM60
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM60

No disorders were found for TRIM60 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM60 Gene

Publications for TRIM60 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Does this have a familiar RING? (PMID: 8744354) Saurin A.J. … Freemont P.S. (Trends Biochem. Sci. 1996) 3

Products for TRIM60 Gene

Sources for TRIM60 Gene

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