TRIM60 Gene
protein-coding GIFtS: 41
GCID: GC04P165953
|
|
tripartite motif containing 60(Previous names: ring finger protein 129, tripartite motif-containing 6...)
(Previous symbols: RNF129, RNF33)
| |
Aliases
for TRIM60 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 601 2 | | Tripartite Motif-Containing 601 2 | | RING Finger Protein 1291 2 3 | | RING Finger Protein 332 3 | | RNF1291 2 3 | | FLJ358821 | | RNF331 2 3 | | Tripartite Motif-Containing Protein 602 |
Export aliases for TRIM60 gene to outside databasesPrevious GC identifers: GC04P166311 GC04P166172 GC04P161706 |
Summaries
for TRIM60 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM60:
The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinctproteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene arelocated on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding thesame protein, have been identified. (provided by RefSeq, Jan 2013)
|
Genomic Views
for TRIM60 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_016354.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM60 gene promoter:
GR RFX1 AML1a NCX/Ncx Brachyury RelA Nkx2-5 Pax-3 ARP-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM60
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM60 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4q32.3 Ensembl cytogenetic band: 4q32.3 HGNC cytogenetic band: 4q32.3TRIM60 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P165953: view genomic region
(about GC identifiers)
Start:
|
165,953,105 bp from pter |
End:
|
165,962,896 bp from pter |
Size:
|
9,792 bases |
Orientation:
|
plus strand |
|
Proteins
for TRIM60 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI60_HUMAN, Q495X7 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 60 Size: 471 amino acids; 55114 Da
Secondary accessions: Q8NA35Explore the universe of human proteins at neXtProt for TRIM60: NX_Q495X7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q495X7
TRIM60 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001244954.1 NP_689833.1
ENSEMBL proteins: ENSP00000421142 ENSP00000421784 ENSP00000426496 ENSP00000343765
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM60 for ontologies About GeneDecksing
TRIM60 Antibody Products:
Assay Products for TRIM60: |
Protein
Domains /
Families
for TRIM60 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM60 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q495X7ProtoNet protein and cluster: Q495X7 3 Blocks protein families: IPB000315 B-box zinc finger signature IPB003879 Butyrophylin C-terminal DUF signature IPB006574 SPRY-associated domain
UniProtKB/Swiss-Prot: TRI60_HUMAN, Q495X7Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM60 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM60 (NM_152620) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM60 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM60 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM60 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM60 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TRIM60:
|
Pathways & Interactions
for TRIM60 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM60
|
Drugs & Compounds
for TRIM60 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM60
Search CenterWatch for drugs/clinical trials and news about TRIM60 / TRI60
|
Transcripts
for TRIM60 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM60 gene (2 alternative transcripts): NM_001258025.1 NM_152620.2 Unigene Cluster for TRIM60: Tripartite motif containing 60 Hs.368004 [show with all ESTs]Unigene Representative Sequence: NM_0012580254 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000512596(uc003iqy.1 uc010iqx.1) ENST00000507119 ENST00000508504
ENST00000341062
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM60 (NM_152620) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM60 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM60 |
Additional cDNA sequence: AK093201.1 BC100983.1 BC100984.1 BC100985.1 BC100986.2 1 DOTS entry: DT.100017163 6 AceView cDNA sequences: AA700389 NM_152620 BX114353 AX747987 AK093201 AA908904
GeneLoc Exon Structure
|
Expression
for TRIM60 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM60 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCCAATAAAA
About this image
See TRIM60 Protein Expression from SPIRE MOPED and PaxDB
SOURCE GeneReport for Unigene cluster: Hs.368004
SABiosciences Custom PCR Arrays for TRIM60
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM60
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM60 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM60 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM60 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM60 |
Orthologs
for TRIM60 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM60 gene from 1/4 species (see all 4) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
23(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM60 (if available)
TreeFam Gene Tree for TRIM60 (if available) |
Paralogs
for TRIM60 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM60 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM582
- TRIM682 TRIM102 TRIM152 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/49 SIMAP similar genes for TRIM60 using alignment to 2 protein entries: TRI60_HUMAN (see all proteins)
(see all similar genes):TRIM61 TRIM73 TRIM39 TRIM75 TRIM39R TRIM5
TRIM41 TRIM26 RNF170 TRIM68 BFAR PCGF3
TRAF5 TRIM17 CHFR RNF138 TRAF4 RFWD2
TRIM60 for paralogs About GeneDecksing
5/31 Pseudogenes.org Pseudogenes for TRIM60 (see all 31)
PGOHUM00000251273 PGOHUM00000256696 PGOHUM00000248457 PGOHUM00000256732 PGOHUM00000244400
|
Genomic Variants
for TRIM60 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRIM60
1 CNV: 3524 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM60 |
|
Disorders
/ Diseases
for TRIM60 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRIM60 for disorders About MalaCards
TRIM60 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TRIM60 (1 document)
Export disorders for TRIM60 gene to outside databases
|
Publications
for TRIM60 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM60 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM60) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061)1 Trynka G....Wijmenga C. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Does this have a familiar RING? (PubMed id 8744354)1 Saurin A.J....Freemont P.S. (1996)
|
External Searches for TRIM60 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM60 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM60 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM60 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM60 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TRIM60 gene:
Search GeneIP for patents involving TRIM60
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM60 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM60 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM60 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM60 | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM60 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM60 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM60 | | OriGene Custom Protein Services for TRIM60 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM60 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM60 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM60 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM60 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM60 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM60 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TRIM60 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TRIM60 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM60 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM60 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM60 |
|
|
|
|
