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Aliases for TRIM60 Gene

Aliases for TRIM60 Gene

  • Tripartite Motif Containing 60 2 3
  • Tripartite Motif-Containing 60 2 3
  • Ring Finger Protein 129 2 3
  • RNF129 3 4
  • RNF33 3 4
  • Tripartite Motif-Containing Protein 60 3
  • RING Finger Protein 129 4
  • Ring Finger Protein 33 3
  • RING Finger Protein 33 4

External Ids for TRIM60 Gene

Previous Symbols for TRIM60 Gene

  • RNF129
  • RNF33

Summaries for TRIM60 Gene

Entrez Gene Summary for TRIM60 Gene

  • The protein encoded by this gene contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. Pseudogenes of this gene are located on more than six chromosomes including chromosome 4. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2013]

GeneCards Summary for TRIM60 Gene

TRIM60 (Tripartite Motif Containing 60) is a Protein Coding gene. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM60 Gene

Genomics for TRIM60 Gene

Genomic Location for TRIM60 Gene

Start:
165,031,953 bp from pter
End:
165,041,744 bp from pter
Size:
9,792 bases
Orientation:
Plus strand

Genomic View for TRIM60 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM60 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM60 Gene

Regulatory Elements for TRIM60 Gene

Proteins for TRIM60 Gene

  • Protein details for TRIM60 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q495X7-TRI60_HUMAN
    Recommended name:
    Tripartite motif-containing protein 60
    Protein Accession:
    Q495X7
    Secondary Accessions:
    • Q8NA35

    Protein attributes for TRIM60 Gene

    Size:
    471 amino acids
    Molecular mass:
    55114 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM60 Gene

Proteomics data for TRIM60 Gene at MOPED

Post-translational modifications for TRIM60 Gene

No Post-translational modifications

Other Protein References for TRIM60 Gene

No data available for DME Specific Peptides for TRIM60 Gene

Domains for TRIM60 Gene

Gene Families for TRIM60 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI60_HUMAN
Domain:
  • Contains 1 B30.2/SPRY domain.:
    • Q495X7
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q495X7
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q495X7
  • Contains 1 RING-type zinc finger.:
    • Q495X7
genes like me logo Genes that share domains with TRIM60: view

Function for TRIM60 Gene

Gene Ontology (GO) - Molecular Function for TRIM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM60: view
genes like me logo Genes that share phenotypes with TRIM60: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM60 Gene

Localization for TRIM60 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM60 Gene COMPARTMENTS Subcellular localization image for TRIM60 gene
Compartment Confidence
nucleus 3
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM60 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM60: view

Pathways for TRIM60 Gene

SuperPathways for TRIM60 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM60 Gene

None

No data available for Pathways by source for TRIM60 Gene

Transcripts for TRIM60 Gene

mRNA/cDNA for TRIM60 Gene

(5) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(6) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM60 Gene

Tripartite motif containing 60:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM60 Gene

No ASD Table

Relevant External Links for TRIM60 Gene

GeneLoc Exon Structure for
TRIM60
ECgene alternative splicing isoforms for
TRIM60

Expression for TRIM60 Gene

mRNA expression in normal human tissues for TRIM60 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM60 Gene

This gene is overexpressed in Testis (51.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM60 Gene

SOURCE GeneReport for Unigene cluster for TRIM60 Gene Hs.368004

genes like me logo Genes that share expressions with TRIM60: view

Orthologs for TRIM60 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM60 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM60 36
  • 98.73 (n)
  • 97.66 (a)
TRIM60 37
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM61 36
  • 79.02 (n)
  • 70.18 (a)
mouse
(Mus musculus)
Mammalia Trim60 36
  • 67.84 (n)
  • 53.96 (a)
Trim60 16
Trim60 37
  • 52 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 37
  • 23 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM60 37
  • 49 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM7.2 37
  • 28 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 29 (a)
ManyToMany
Species with no ortholog for TRIM60:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM60 Gene

ENSEMBL:
Gene Tree for TRIM60 (if available)
TreeFam:
Gene Tree for TRIM60 (if available)

Paralogs for TRIM60 Gene

genes like me logo Genes that share paralogs with TRIM60: view

Variants for TRIM60 Gene

Sequence variations from dbSNP and Humsavar for TRIM60 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs950268 -- 165,040,697(-) CATCT(A/C)TTCAT reference, stop-gained
rs4133108 -- 165,031,283(-) AGACA(C/G)TGAAA upstream-variant-2KB
rs4133109 -- 165,031,206(-) tgaga(C/T)ggagt upstream-variant-2KB
rs4690800 -- 165,030,838(+) GATCC(A/G)CCCGC upstream-variant-2KB
rs6536886 -- 165,032,103(+) GTCCA(A/G)CTGCT utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM60 Gene

Variant ID Type Subtype PubMed ID
nsv880382 CNV Gain 21882294
dgv1711e1 CNV Complex 17122850
nsv830140 CNV Loss 17160897
esv2728685 CNV Deletion 23290073

Relevant External Links for TRIM60 Gene

HapMap Linkage Disequilibrium report
TRIM60

Disorders for TRIM60 Gene

Relevant External Links for TRIM60

Genetic Association Database (GAD)
TRIM60
Human Genome Epidemiology (HuGE) Navigator
TRIM60
genes like me logo Genes that share disorders with TRIM60: view

No data available for UniProtKB/Swiss-Prot for TRIM60 Gene

Publications for TRIM60 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 49
  4. Does this have a familiar RING? (PMID: 8744354) Saurin A.J. … Freemont P.S. (Trends Biochem. Sci. 1996) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRIM60 Gene

Sources for TRIM60 Gene

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