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TRIM6-TRIM34 Gene

protein-coding   GIFtS: 33
GCID: GC11P005618

TRIM6-TRIM34 Readthrough

  Search for TRIM6-TRIM34
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
TRIM6-TRIM34 Readthrough1 2     Interferon-Responsive Finger Protein 1 Long Form2
IFP12     Tripartite Motif-Containing 6 And Tripartite Motif-Containing 342
RNF212     TRIM6-TRIM34 Readthrough Transcript4
TRIM342     

External Ids:    HGNC: 334401   Entrez Gene: 4453722   Ensembl: ENSG000002585887   UniProtKB: B2RNG44   

Export aliases for TRIM6-TRIM34 gene to outside databases

Previous GC identifers: GC11U900629 GC11P005578 GC11P005277


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM6-TRIM34 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a
readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene
is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. (provided by RefSeq, Nov 2009)

GeneCards Summary for TRIM6-TRIM34 Gene:
TRIM6-TRIM34 (TRIM6-TRIM34 readthrough) is a protein-coding gene. An important paralog of this gene is TRIM7.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM6-TRIM34 gene promoter:
         Sp1   AP-1   MyoD   LCR-F1   NF-AT   Meis-1b   C/EBPalpha   Meis-1a   NF-AT1   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): TRIM6-TRIM34 promoter sequence
   Search Chromatin IP Primers for TRIM6-TRIM34

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM6-TRIM34


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15.4

TRIM6-TRIM34 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM6-TRIM34 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005618:  view genomic region     (about GC identifiers)

Start:
5,617,865 bp from pter      End:
5,665,628 bp from pter
Size:
47,764 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/TrEMBL: B2RNG4 (See protein sequence)
Recommended Name: Protein TRIM6-TRIM34  
Size: 842 amino acids; 97729 Da

Explore proteomics data for TRIM6-TRIM34 at MOPED


See TRIM6-TRIM34 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_001003819.1  
ENSEMBL proteins: 
 ENSP00000346916   ENSP00000395982  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Selected InterPro protein domains (see all 9):
 IPR017907 Znf_RING_CS
 IPR001841 Znf_RING
 IPR001870 B30.2/SPRY
 IPR003877 SPRY_rcpt
 IPR000315 Znf_B-box

Graphical View of Domain Structure for InterPro Entry B2RNG4

ProtoNet protein and cluster: B2RNG4

UniProtKB/TrEMBL: B2RNG4
Similarity: Contains B30.2/SPRY domain
Similarity: Contains RING-type zinc finger


TRIM6-TRIM34 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 4 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003674molecular_function ----
GO:0005515protein binding ----
GO:0008270zinc ion binding ----
GO:0046872metal ion binding ----
     
TRIM6-TRIM34 for ontologies           About GeneDecksing


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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005622intracellular ----
GO:0005737cytoplasm ----

TRIM6-TRIM34 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM6-TRIM34
Interactions:

    Search GeneGlobe Interaction Network for TRIM6-TRIM34

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5 Interacting proteins for TRIM6-TRIM34 (ENSP000003469164) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
MRPL12ENSP000003338374STRING: ENSP00000333837
SRP9ENSP000003052304STRING: ENSP00000305230
NTRK1ENSP000003514864STRING: ENSP00000351486
SQSTM1ENSP000003744554STRING: ENSP00000374455
--ENSP000003151394STRING: ENSP00000315139
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Gene Ontology (GO): 1 biological process term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0070206protein trimerization ----

TRIM6-TRIM34 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TRIM6-TRIM34



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TRIM6-TRIM34 gene: 
NM_001003819.3  

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000354852(uc001mbf.3) ENST00000457787
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TRIM6-TRIM34 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TRIM6-TRIM34 Expression
About this image

TRIM6-TRIM34 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TRIM6-TRIM34 Protein Expression
    Custom PCR Arrays for TRIM6-TRIM34
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of chordates.

Orthologs for TRIM6-TRIM34 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Trim34b1 , 5 tripartite motif-containing 34B1, 5 76.77(n)1
68.04(a)1
  7 (55.69 cM)5
4342181  NM_001243916.11  NP_001230845.11 
 1043002305 
chicken
(Gallus gallus)
Aves --
Uncharacterized protein
32(a)
1 → many
19(353752-359048) ENSGALG00000000865
lizard
(Anolis carolinensis)
Reptilia --
--
32(a)
1 → many
GL343252.1(1250717-1269864)


ENSEMBL Gene Tree for TRIM6-TRIM34 (if available)
TreeFam Gene Tree for TRIM6-TRIM34 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for TRIM6-TRIM34 gene
TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  
TRIM602  TRIM222  TRIM172  TRIM52  TRIM62  TRIM212  TRIM382  TRIM112  
TRIM39-RPP212  
Selected SIMAP similar genes for TRIM6-TRIM34 using alignment to 2 protein entries:     B2RNG4_HUMAN (see all proteins) (see all similar genes):
TRIM34    TRIM6    TRIM22    DKFZp781D1977    TRIM5    DKFZp686F23130
TRIM21    TRIM38    BT3.3    TRIM11    TRIM60    TRIM17
TRIM48    TRIM73    TRIM74    TRIML1    TRIM27    TRIM43

TRIM6-TRIM34 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TRIM6-TRIM34 (see all 137)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 11 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1884372751,2
--5298009(+) CTCACC/TAATAT 1 -- int10--------
rs1497770721,2
--5298033(+) TAGTGC/TCCTAT 1 -- int10--------
rs1455916111,2
C--5298053(+) AGTATA/TTAAGT 1 -- int10--------
rs1914450521,2
--5298082(+) CCTCTA/GTTGCA 1 -- int10--------
rs1414321461,2
--5298178(+) GAAAAC/GTGTCG 1 -- int10--------
rs4444591,2
C,F,A,H--5298182(-) GTACCG/AACAGT 1 -- int113Minor allele frequency- A:0.14NS EA NA WA 1198
rs1855799041,2
--5298264(+) AAAAGA/GAGGGT 1 -- int10--------
rs1453232551,2
--5298304(+) CTGTCA/GTAAGA 1 -- int10--------
rs1476097271,2
--5298347(+) CGCTTC/TGACGA 1 -- int10--------
rs1422056161,2
--5298350(+) TTCGAC/TGAGGA 1 -- int10--------

HapMap Linkage Disequilibrium report for TRIM6-TRIM34 (5617865 - 5665628 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TRIM6-TRIM34 (see all 15):    About this table    
Variant IDTypeSubtypePubMed ID
esv2671670CNV Deletion23128226
esv2549687CNV Deletion19546169
esv2744063CNV Deletion23290073
esv2658921CNV Deletion23128226
dgv188e199CNV Deletion23128226
nsv896947CNV Loss21882294
nsv896939CNV Loss21882294
nsv825740CNV Loss20364138
dgv1027n71CNV Loss21882294
nsv896945CNV Loss21882294

Site Specific Mutation Identification with PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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TRIM6-TRIM34 for disorders           About GeneDecksing

Genetic Association Database (GAD): TRIM6-TRIM34

Export disorders for TRIM6-TRIM34 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TRIM6-TRIM34 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TRIM6-TRIM34)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
  2. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
  3. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
  4. Global identification of modular cullin-RING ligase substrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (Cell 2011)
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (PLoS ONE 2010)
  6. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
  7. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PubMed id 16775307)1 Li X....Sodroski J. (J. Virol. 2006)
  8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  9. Molecular cloning of ring finger protein 21 (RNF21)/interferon- responsive finger protein (ifp1), which possesses two RING-B box- coiled coil domains in tandem. (PubMed id 11013086)1 Orimo A.... Muramatsu M. (Genomics 2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 445372 HGNC: 33440 Ensembl:ENSG00000258588 euGenes: HUgn445372 ECgene: TRIM6-TRIM34
H-InvDB: TRIM6-TRIM34

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TRIM6-TRIM34 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TRIM6-TRIM34 gene:
Search GeneIP for patents involving TRIM6-TRIM34

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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