Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM6-TRIM34 Gene

Aliases for TRIM6-TRIM34 Gene

  • TRIM6-TRIM34 Readthrough 2 3 5
  • Tripartite Motif-Containing 6 And Tripartite Motif-Containing 34 3
  • Interferon-Responsive Finger Protein 1 Long Form 3
  • TRIM34 3
  • RNF21 3
  • IFP1 3

External Ids for TRIM6-TRIM34 Gene

Previous GeneCards Identifiers for TRIM6-TRIM34 Gene

  • GC11U900629
  • GC11P005578
  • GC11P005277

Summaries for TRIM6-TRIM34 Gene

Entrez Gene Summary for TRIM6-TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009]

GeneCards Summary for TRIM6-TRIM34 Gene

TRIM6-TRIM34 (TRIM6-TRIM34 Readthrough) is a Protein Coding gene. An important paralog of this gene is TRIM34.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM6-TRIM34 Gene

Genomics for TRIM6-TRIM34 Gene

Regulatory Elements for TRIM6-TRIM34 Gene

Enhancers for TRIM6-TRIM34 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around TRIM6-TRIM34 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM6-TRIM34 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM6-TRIM34 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM6-TRIM34 Gene

Chromosome:
11
Start:
5,596,635 bp from pter
End:
5,644,398 bp from pter
Size:
47,764 bases
Orientation:
Plus strand

Genomic View for TRIM6-TRIM34 Gene

Genes around TRIM6-TRIM34 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM6-TRIM34 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM6-TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM6-TRIM34 Gene

Proteins for TRIM6-TRIM34 Gene

  • Protein details for TRIM6-TRIM34 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B2RNG4
    Recommended name:
    Protein TRIM6-TRIM34
    Protein Accession:
    B2RNG4

    Protein attributes for TRIM6-TRIM34 Gene

    Size:
    842 amino acids
    Molecular mass:
    97729 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM6-TRIM34 Gene

Post-translational modifications for TRIM6-TRIM34 Gene

No Post-translational modifications

Other Protein References for TRIM6-TRIM34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM6-TRIM34 Gene

Domains & Families for TRIM6-TRIM34 Gene

Gene Families for TRIM6-TRIM34 Gene

Suggested Antigen Peptide Sequences for TRIM6-TRIM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM6-TRIM34: view

No data available for UniProtKB/Swiss-Prot for TRIM6-TRIM34 Gene

Function for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM6-TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM6-TRIM34: view
genes like me logo Genes that share phenotypes with TRIM6-TRIM34: view

Animal Model Products

CRISPR Products

miRNA for TRIM6-TRIM34 Gene

miRTarBase miRNAs that target TRIM6-TRIM34

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM6-TRIM34 Gene

Localization for TRIM6-TRIM34 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TRIM6-TRIM34 Gene

Pathways & Interactions for TRIM6-TRIM34 Gene

SuperPathways for TRIM6-TRIM34 Gene

No Data Available

Interacting Proteins for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Biological Process for TRIM6-TRIM34 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM6-TRIM34 Gene

Drugs & Compounds for TRIM6-TRIM34 Gene

No Compound Related Data Available

Transcripts for TRIM6-TRIM34 Gene

mRNA/cDNA for TRIM6-TRIM34 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6-TRIM34 Gene

No ASD Table

Relevant External Links for TRIM6-TRIM34 Gene

GeneLoc Exon Structure for
TRIM6-TRIM34
ECgene alternative splicing isoforms for
TRIM6-TRIM34

Expression for TRIM6-TRIM34 Gene

mRNA expression in normal human tissues for TRIM6-TRIM34 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb, MaxQB, and MOPED for TRIM6-TRIM34 Gene



genes like me logo Genes that share expression patterns with TRIM6-TRIM34: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM6-TRIM34 Gene

Orthologs for TRIM6-TRIM34 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM6-TRIM34 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TRIM34 34
  • 81.66 (n)
  • 72.07 (a)
rat
(Rattus norvegicus)
Mammalia Trim34 34
  • 77.25 (n)
  • 67.43 (a)
cow
(Bos Taurus)
Mammalia -- 35
  • 73 (a)
OneToMany
TRIM34 34
  • 82.3 (n)
  • 72.63 (a)
mouse
(Mus musculus)
Mammalia Trim34b 34
  • 76.77 (n)
  • 68.04 (a)
Trim34b 16
chicken
(Gallus gallus)
Aves -- 35
  • 32 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 32 (a)
OneToMany
Species where no ortholog for TRIM6-TRIM34 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM6-TRIM34 Gene

ENSEMBL:
Gene Tree for TRIM6-TRIM34 (if available)
TreeFam:
Gene Tree for TRIM6-TRIM34 (if available)

Paralogs for TRIM6-TRIM34 Gene

genes like me logo Genes that share paralogs with TRIM6-TRIM34: view

Variants for TRIM6-TRIM34 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM6-TRIM34 Gene

Variant ID Type Subtype PubMed ID
dgv1604n54 CNV loss 21841781
dgv1605n54 CNV loss 21841781
dgv1606n54 CNV loss 21841781
dgv188e199 CNV deletion 23128226
esv25239 CNV loss 19812545
esv2549687 CNV deletion 19546169
esv2658921 CNV deletion 23128226
esv2671670 CNV deletion 23128226
esv2744063 CNV deletion 23290073
esv2760210 CNV gain 21179565
esv3547256 CNV deletion 23714750
esv3547257 CNV deletion 23714750
esv3625236 CNV loss 21293372
esv3625237 CNV loss 21293372
esv3625238 CNV loss 21293372
esv3625239 CNV loss 21293372
esv3625240 CNV loss 21293372
esv3625241 CNV loss 21293372
esv3891920 CNV loss 25118596
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1048455 CNV gain 25217958
nsv1048608 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv1054035 CNV gain 25217958
nsv1070431 CNV deletion 25765185
nsv1122581 CNV deletion 24896259
nsv1126284 CNV deletion 24896259
nsv471746 CNV loss 16327809
nsv553241 CNV gain 21841781
nsv553260 CNV loss 21841781
nsv553272 CNV loss 21841781
nsv553273 CNV gain 21841781
nsv819802 CNV loss 19587683
nsv825739 CNV loss 20364138
nsv825740 CNV loss 20364138

Variation tolerance for TRIM6-TRIM34 Gene

Residual Variation Intolerance Score: 46.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.51; 71.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM6-TRIM34 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM6-TRIM34

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRIM6-TRIM34 Gene

Disorders for TRIM6-TRIM34 Gene

Relevant External Links for TRIM6-TRIM34

Genetic Association Database (GAD)
TRIM6-TRIM34
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM6-TRIM34

No disorders were found for TRIM6-TRIM34 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM6-TRIM34 Gene

Publications for TRIM6-TRIM34 Gene

  1. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3 65
  2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3 65
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 65
  4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X. … Sodroski J. (J. Virol. 2006) 3 65
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 65

Products for TRIM6-TRIM34 Gene

Sources for TRIM6-TRIM34 Gene

Content