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Aliases for TRIM6-TRIM34 Gene

Aliases for TRIM6-TRIM34 Gene

  • TRIM6-TRIM34 Readthrough 2 3
  • Interferon-Responsive Finger Protein 1 Long Form 3
  • TRIM34 3
  • RNF21 3
  • IFP1 3

External Ids for TRIM6-TRIM34 Gene

Previous GeneCards Identifiers for TRIM6-TRIM34 Gene

  • GC11U900629
  • GC11P005578
  • GC11P005277

Summaries for TRIM6-TRIM34 Gene

Entrez Gene Summary for TRIM6-TRIM34 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This gene represents a readthrough transcript from genes TRIM6 and TRIM34, and it was described as a splice variant of TRIM34. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. [provided by RefSeq, Nov 2009]

GeneCards Summary for TRIM6-TRIM34 Gene

TRIM6-TRIM34 (TRIM6-TRIM34 Readthrough) is a Protein Coding gene. Among its related pathways are Immune System and Interleukin receptor SHC signaling. An important paralog of this gene is TRIM58.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM6-TRIM34 Gene

Genomics for TRIM6-TRIM34 Gene

Regulatory Elements for TRIM6-TRIM34 Gene

Genomic Location for TRIM6-TRIM34 Gene

Chromosome:
11
Start:
5,596,635 bp from pter
End:
5,644,398 bp from pter
Size:
47,764 bases
Orientation:
Plus strand

Genomic View for TRIM6-TRIM34 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM6-TRIM34 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM6-TRIM34 Gene

Proteins for TRIM6-TRIM34 Gene

  • Protein details for TRIM6-TRIM34 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    B2RNG4
    Recommended name:
    Protein TRIM6-TRIM34
    Protein Accession:
    B2RNG4

    Protein attributes for TRIM6-TRIM34 Gene

    Size:
    842 amino acids
    Molecular mass:
    97729 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM6-TRIM34 Gene

Proteomics data for TRIM6-TRIM34 Gene at MOPED

Post-translational modifications for TRIM6-TRIM34 Gene

No Post-translational modifications

Other Protein References for TRIM6-TRIM34 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM6-TRIM34 Gene

Domains & Families for TRIM6-TRIM34 Gene

Gene Families for TRIM6-TRIM34 Gene

Protein Domains for TRIM6-TRIM34 Gene

Suggested Antigen Peptide Sequences for TRIM6-TRIM34 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM6-TRIM34: view

No data available for UniProtKB/Swiss-Prot for TRIM6-TRIM34 Gene

Function for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Molecular Function for TRIM6-TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with TRIM6-TRIM34: view

Phenotypes for TRIM6-TRIM34 Gene

GenomeRNAi human phenotypes for TRIM6-TRIM34:
genes like me logo Genes that share phenotypes with TRIM6-TRIM34: view

Animal Model Products

CRISPR Products

miRNA for TRIM6-TRIM34 Gene

miRTarBase miRNAs that target TRIM6-TRIM34

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM6-TRIM34 Gene

Localization for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Cellular Components for TRIM6-TRIM34 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with TRIM6-TRIM34: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRIM6-TRIM34 Gene

Pathways & Interactions for TRIM6-TRIM34 Gene

genes like me logo Genes that share pathways with TRIM6-TRIM34: view

Pathways by source for TRIM6-TRIM34 Gene

Interacting Proteins for TRIM6-TRIM34 Gene

Gene Ontology (GO) - Biological Process for TRIM6-TRIM34 Gene

None

No data available for SIGNOR curated interactions for TRIM6-TRIM34 Gene

Drugs & Compounds for TRIM6-TRIM34 Gene

No Compound Related Data Available

Transcripts for TRIM6-TRIM34 Gene

mRNA/cDNA for TRIM6-TRIM34 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

miRNA Products

  • QIAGEN qRT-PCR Assays for microRNAs that regulate TRIM6-TRIM34
    • Block miRNA regulation of TRIM6-TRIM34 using miScript Target Protectors

    Inhibitory RNA Products

    • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM6-TRIM34

    Flow Cytometry Products

    Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6-TRIM34 Gene

    No ASD Table

    Relevant External Links for TRIM6-TRIM34 Gene

    GeneLoc Exon Structure for
    TRIM6-TRIM34
    ECgene alternative splicing isoforms for
    TRIM6-TRIM34

    Expression for TRIM6-TRIM34 Gene

    mRNA expression in normal human tissues for TRIM6-TRIM34 Gene

    Integrated Proteomics: protein expression in normal tissues and cell lines from MaxQB for TRIM6-TRIM34 Gene



    genes like me logo Genes that share expression patterns with TRIM6-TRIM34: view

    Primer Products

    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat

    In Situ Assay Products

    No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM6-TRIM34 Gene

    Orthologs for TRIM6-TRIM34 Gene

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM6-TRIM34 Gene

    Organism Taxonomy Gene Similarity Type Details
    cow
    (Bos Taurus)
    Mammalia TRIM34 35
    • 82.3 (n)
    • 72.63 (a)
    -- 36
    • 73 (a)
    OneToMany
    dog
    (Canis familiaris)
    Mammalia TRIM34 35
    • 81.66 (n)
    • 72.07 (a)
    mouse
    (Mus musculus)
    Mammalia Trim34b 35
    • 76.77 (n)
    • 68.04 (a)
    Trim34b 16
    rat
    (Rattus norvegicus)
    Mammalia Trim34 35
    • 77.25 (n)
    • 67.43 (a)
    chicken
    (Gallus gallus)
    Aves -- 36
    • 32 (a)
    OneToMany
    lizard
    (Anolis carolinensis)
    Reptilia -- 36
    • 32 (a)
    OneToMany
    Species with no ortholog for TRIM6-TRIM34:
    • A. gosspyii yeast (Ashbya gossypii)
    • Actinobacteria (Mycobacterium tuberculosis)
    • African clawed frog (Xenopus laevis)
    • African malaria mosquito (Anopheles gambiae)
    • Alicante grape (Vitis vinifera)
    • alpha proteobacteria (Wolbachia pipientis)
    • amoeba (Dictyostelium discoideum)
    • Archea (Pyrococcus horikoshii)
    • baker's yeast (Saccharomyces cerevisiae)
    • barley (Hordeum vulgare)
    • beta proteobacteria (Neisseria meningitidis)
    • bread mold (Neurospora crassa)
    • chimpanzee (Pan troglodytes)
    • Chromalveolata (Phytophthora infestans)
    • common water flea (Daphnia pulex)
    • corn (Zea mays)
    • E. coli (Escherichia coli)
    • filamentous fungi (Aspergillus nidulans)
    • Firmicute bacteria (Streptococcus pneumoniae)
    • fission yeast (Schizosaccharomyces pombe)
    • fruit fly (Drosophila melanogaster)
    • green algae (Chlamydomonas reinhardtii)
    • honey bee (Apis mellifera)
    • K. lactis yeast (Kluyveromyces lactis)
    • loblloly pine (Pinus taeda)
    • malaria parasite (Plasmodium falciparum)
    • medicago trunc (Medicago Truncatula)
    • moss (Physcomitrella patens)
    • oppossum (Monodelphis domestica)
    • orangutan (Pongo pygmaeus)
    • pig (Sus scrofa)
    • platypus (Ornithorhynchus anatinus)
    • rainbow trout (Oncorhynchus mykiss)
    • rice (Oryza sativa)
    • rice blast fungus (Magnaporthe grisea)
    • schistosome parasite (Schistosoma mansoni)
    • sea anemone (Nematostella vectensis)
    • sea squirt (Ciona intestinalis)
    • sea squirt (Ciona savignyi)
    • sea urchin (Strongylocentrotus purpuratus)
    • sorghum (Sorghum bicolor)
    • soybean (Glycine max)
    • stem rust fungus (Puccinia graminis)
    • sugarcane (Saccharum officinarum)
    • thale cress (Arabidopsis thaliana)
    • tomato (Lycopersicon esculentum)
    • toxoplasmosis (Toxoplasma gondii)
    • Trichoplax (Trichoplax adhaerens)
    • tropical clawed frog (Silurana tropicalis)
    • wheat (Triticum aestivum)
    • worm (Caenorhabditis elegans)
    • zebrafish (Danio rerio)

    Evolution for TRIM6-TRIM34 Gene

    ENSEMBL:
    Gene Tree for TRIM6-TRIM34 (if available)
    TreeFam:
    Gene Tree for TRIM6-TRIM34 (if available)

    Paralogs for TRIM6-TRIM34 Gene

    genes like me logo Genes that share paralogs with TRIM6-TRIM34: view

    Variants for TRIM6-TRIM34 Gene

    Structural Variations from Database of Genomic Variants (DGV) for TRIM6-TRIM34 Gene

    Variant ID Type Subtype PubMed ID
    nsv896939 CNV Loss 21882294
    dgv1027n71 CNV Loss 21882294
    nsv896945 CNV Loss 21882294
    nsv896946 CNV Loss 21882294
    nsv471746 CNV Loss 16327809
    esv2658921 CNV Deletion 23128226
    nsv896947 CNV Loss 21882294
    nsv825739 CNV Loss 20364138
    nsv819802 CNV Loss 19587683
    esv2549687 CNV Deletion 19546169
    dgv188e199 CNV Deletion 23128226
    esv2671670 CNV Deletion 23128226
    esv2744063 CNV Deletion 23290073
    nsv825740 CNV Loss 20364138
    esv25239 CNV Loss 19812545

    Variation tolerance for TRIM6-TRIM34 Gene

    Residual Variation Intolerance Score: 46.33% of all genes are more intolerant (likely to be disease-causing)
    Gene Damage Index Score: 5.51; 71.88% of all genes are more intolerant (likely to be disease-causing)

    Relevant External Links for TRIM6-TRIM34 Gene

    HapMap Linkage Disequilibrium report
    TRIM6-TRIM34

    No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRIM6-TRIM34 Gene

    Disorders for TRIM6-TRIM34 Gene

    Relevant External Links for TRIM6-TRIM34

    Genetic Association Database (GAD)
    TRIM6-TRIM34
    Atlas of Genetics and Cytogenetics in Oncology and Haematology:
    TRIM6-TRIM34
    genes like me logo Genes that share disorders with TRIM6-TRIM34: view

    No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM6-TRIM34 Gene

    Publications for TRIM6-TRIM34 Gene

    1. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 67
    2. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 67
    3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 67
    4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X. … Sodroski J. (J. Virol. 2006) 67
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

    Products for TRIM6-TRIM34 Gene

    Sources for TRIM6-TRIM34 Gene

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