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Aliases for TRIM6 Gene

Aliases for TRIM6 Gene

  • Tripartite Motif Containing 6 2 3 5
  • Tripartite Motif-Containing 6 2 3
  • RING Finger Protein 89 3 4
  • RNF89 3 4
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for TRIM6 Gene

Previous GeneCards Identifiers for TRIM6 Gene

  • GC11P006365
  • GC11P005919
  • GC11P005576
  • GC11P005581
  • GC11P005573
  • GC11P005276

Summaries for TRIM6 Gene

Entrez Gene Summary for TRIM6 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRIM6 Gene

TRIM6 (Tripartite Motif Containing 6) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM58.

UniProtKB/Swiss-Prot for TRIM6 Gene

  • E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).

Gene Wiki entry for TRIM6 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM6 Gene

Genomics for TRIM6 Gene

Regulatory Elements for TRIM6 Gene

Enhancers for TRIM6 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM6 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM6 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM6 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM6 Gene

Chromosome:
11
Start:
5,596,101 bp from pter
End:
5,612,958 bp from pter
Size:
16,858 bases
Orientation:
Plus strand

Genomic View for TRIM6 Gene

Genes around TRIM6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM6 Gene

Proteins for TRIM6 Gene

  • Protein details for TRIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C030-TRIM6_HUMAN
    Recommended name:
    Tripartite motif-containing protein 6
    Protein Accession:
    Q9C030
    Secondary Accessions:
    • A8K2A7
    • B4DDQ5
    • Q86WZ8
    • Q9HCR1

    Protein attributes for TRIM6 Gene

    Size:
    488 amino acids
    Molecular mass:
    56400 Da
    Quaternary structure:
    • Homotrimer (PubMed:17156811). Forms heteromultimers (via B30.2/SPRY domain) with TRIM5 (PubMed:21680743). Interacts with MYC (By similarity). Interacts (via SPRY domain) with IKBKE (PubMed:24882218). Interacts with HIV-1 capsid complexes (PubMed:17156811).
    SequenceCaution:
    • Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The in vivo relevance of this transcript of the TRIM34 (AC Q9BYJ4) and TRIM6 genes that codes for a chimeric protein of 842 residues is uncertain.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM6 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM6 Gene

Proteomics data for TRIM6 Gene at MOPED

Selected DME Specific Peptides for TRIM6 Gene

Post-translational modifications for TRIM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for TRIM6 Gene

Gene Families for TRIM6 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C030

UniProtKB/Swiss-Prot:

TRIM6_HUMAN :
  • The B-box zinc finger and the linker region between the coiled coil and B30.2/SPRY domains contribute to higher order self-association.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The B-box zinc finger and the linker region between the coiled coil and B30.2/SPRY domains contribute to higher order self-association.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM6: view

Function for TRIM6 Gene

Molecular function for TRIM6 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase which ubiquitinates MYC and inhibits its transcription activation activity, maintaining the pluripotency of embryonic stem cells (By similarity). Involved in the synthesis of unanchored K48-linked polyubiquitin chains which interact with and activate the serine/threonine kinase IKBKE, leading to phosphorylation of STAT1 and stimulation of an antiviral response (PubMed:24882218).

Enzyme Numbers (IUBMB) for TRIM6 Gene

Gene Ontology (GO) - Molecular Function for TRIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM6: view
genes like me logo Genes that share phenotypes with TRIM6: view

Animal Model Products

miRNA for TRIM6 Gene

miRTarBase miRNAs that target TRIM6

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM6 Gene

Localization for TRIM6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM6 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM6 Gene COMPARTMENTS Subcellular localization image for TRIM6 gene
Compartment Confidence
nucleus 4
cytosol 3

No data available for Gene Ontology (GO) - Cellular Components for TRIM6 Gene

Pathways & Interactions for TRIM6 Gene

genes like me logo Genes that share pathways with TRIM6: view

Pathways by source for TRIM6 Gene

UniProtKB/Swiss-Prot Q9C030-TRIM6_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000209 protein polyubiquitination IEA --
GO:0010628 positive regulation of gene expression IEA --
GO:0010800 positive regulation of peptidyl-threonine phosphorylation IMP 24882218
GO:0032496 response to lipopolysaccharide IMP 24882218
GO:0035458 cellular response to interferon-beta IMP 24882218
genes like me logo Genes that share ontologies with TRIM6: view

No data available for SIGNOR curated interactions for TRIM6 Gene

Drugs & Compounds for TRIM6 Gene

No Compound Related Data Available

Transcripts for TRIM6 Gene

Unigene Clusters for TRIM6 Gene

Tripartite motif containing 6:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - -
SP3: - -
SP4: -
SP5:
SP6: -
SP7:
SP8:
SP9:

Relevant External Links for TRIM6 Gene

GeneLoc Exon Structure for
TRIM6
ECgene alternative splicing isoforms for
TRIM6

Expression for TRIM6 Gene

mRNA expression in normal human tissues for TRIM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM6 Gene

This gene is overexpressed in Kidney - Cortex (x9.4).

Protein differential expression in normal tissues from HIPED for TRIM6 Gene

This gene is overexpressed in Bone marrow stromal cell (20.3), Breast (18.4), Uterus (13.1), and Urine (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM6 Gene



SOURCE GeneReport for Unigene cluster for TRIM6 Gene Hs.729048

genes like me logo Genes that share expression patterns with TRIM6: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM6 Gene

Orthologs for TRIM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM6 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM6 35
  • 84.94 (n)
  • 83.37 (a)
-- 36
  • 43 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIM6 35
  • 86.17 (n)
  • 83.16 (a)
mouse
(Mus musculus)
Mammalia Trim6 35
  • 81.63 (n)
  • 80.12 (a)
Trim6 16
Trim6 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM6 35
  • 99.25 (n)
  • 98.98 (a)
TRIM6 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim6 35
  • 81.83 (n)
  • 81.15 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 33 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
OneToMany
Species with no ortholog for TRIM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM6 Gene

ENSEMBL:
Gene Tree for TRIM6 (if available)
TreeFam:
Gene Tree for TRIM6 (if available)

Paralogs for TRIM6 Gene

genes like me logo Genes that share paralogs with TRIM6: view

Variants for TRIM6 Gene

Sequence variations from dbSNP and Humsavar for TRIM6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
VAR_061823 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM6 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv1027n71 CNV Loss 21882294
nsv896945 CNV Loss 21882294
nsv896946 CNV Loss 21882294
nsv471746 CNV Loss 16327809
esv2658921 CNV Deletion 23128226
nsv896947 CNV Loss 21882294

Variation tolerance for TRIM6 Gene

Residual Variation Intolerance Score: 50.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.25; 70.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM6 Gene

Disorders for TRIM6 Gene

Relevant External Links for TRIM6

Genetic Association Database (GAD)
TRIM6
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM6

No disorders were found for TRIM6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM6 Gene

Publications for TRIM6 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4 67
  2. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X. … Sodroski J. (Virology 2007) 3 23
  3. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. (PMID: 18159944) Sawyer S.L. … Malik H.S. (PLoS Pathog. 2007) 3 23
  4. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X. … Sodroski J. (J. Virol. 2006) 3 23
  5. Binding of the rhesus TRIM5I+ PRYSPRY domain to capsid is necessary but not sufficient for HIV-1 restriction. (PMID: 24314652) Yang Y. … Diaz-Griffero F. (Virology 2014) 3

Products for TRIM6 Gene

Sources for TRIM6 Gene

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