Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRIM6 Gene

protein-coding   GIFtS: 47
GCID: GC11P005617

Tripartite Motif Containing 6

(Previous name: tripartite motif-containing 6)
  Search for TRIM6
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tripartite Motif Containing 61 2
Tripartite Motif-Containing 61 2
RNF892 3
RING Finger Protein 892 3
Tripartite Motif-Containing Protein 62
EC 6.3.28

External Ids:    HGNC: 162771   Entrez Gene: 1178542   Ensembl: ENSG000001212367   OMIM: 6075645   UniProtKB: Q9C0303   

Export aliases for TRIM6 gene to outside databases

Previous GC identifers: GC11P006365 GC11P005919 GC11P005576 GC11P005581 GC11P005573 GC11P005276


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRIM6 Gene:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three
zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein
localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome
11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants.
A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in
a fusion product from these neighboring family members. (provided by RefSeq, Oct 2010)

GeneCards Summary for TRIM6 Gene:
TRIM6 (tripartite motif containing 6) is a protein-coding gene. An important paralog of this gene is TRIM7.

Gene Wiki entry for TRIM6 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM6 gene promoter:
         Sp1   AP-1   MyoD   LCR-F1   Meis-1   C/EBPalpha   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TRIM6

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM6


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4   Ensembl cytogenetic band:  11p15.4   HGNC cytogenetic band: 11p15

TRIM6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM6 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P005617:  view genomic region     (about GC identifiers)

Start:
5,617,331 bp from pter      End:
5,634,188 bp from pter
Size:
16,858 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRIM6_HUMAN, Q9C030 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 6  
Size: 488 amino acids; 56400 Da
Subunit: Homomultimer (Probable)
Sequence caution: Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The biological
existence and relevance of this transcript product of both TRIM34 (AC Q9BYJ4) and TRIM6 genes and coding for a
chimeric protein of 842 residues is uncertain;
Secondary accessions: A8K2A7 B4DDQ5 Q86WZ8 Q9HCR1
Alternative splicing: 3 isoforms:  Q9C030-1   Q9C030-2   Q9C030-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM6: NX_Q9C030

Explore proteomics data for TRIM6 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for TRIM6 (Q9C030) (see all 6)
     GYWVIGL  CPICLEL  EEVAQEY  AWILGVC 


    See TRIM6 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001003818.1  NP_001185573.1  NP_001185574.1  NP_477514.1  

    ENSEMBL proteins: 
     ENSP00000278302   ENSP00000414108   ENSP00000427704   ENSP00000369450   ENSP00000369440  
     ENSP00000399215   ENSP00000421802   ENSP00000421079  

    TRIM6 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM6
    OriGene Protein Over-expression Lysate for TRIM6
    OriGene MassSpec for TRIM6
    OriGene Custom Protein Services for TRIM6
    GenScript Custom Purified and Recombinant Proteins Services for TRIM6
    Novus Biologicals TRIM6 Protein
    Novus Biologicals TRIM6 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM6

    TRIM6 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRIM6
    OriGene Custom Antibody Services for TRIM6
    Novus Biologicals TRIM6 Antibodies
    Abcam antibodies for TRIM6
    Cloud-Clone Corp. Antibodies for TRIM6
    Search ThermoFisher Antibodies for TRIM6
    LSBio Antibodies in human, mouse, rat for TRIM6

    TRIM6 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM6
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM6
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM6
    Cloud-Clone Corp. CLIAs for TRIM6


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR006574 PRY
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR003877 SPRY_rcpt

    Graphical View of Domain Structure for InterPro Entry Q9C030

    ProtoNet protein and cluster: Q9C030

    4 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger
    IPB003879 Butyrophylin C-terminal DUF signature
    IPB006574 SPRY-associated domain


    UniProtKB/Swiss-Prot: TRIM6_HUMAN, Q9C030
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM6 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Enzyme Number (IUBMB): EC 6.3.22

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM6 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM6
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM6

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM6
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM6

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM6:
    hsa-mir-26b-5p (MIRT029893)

    Block miRNA regulation of human, mouse, rat TRIM6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TRIM6:
    hsa-miR-205* hsa-miR-33b hsa-miR-33a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM6
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM6

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM6

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM6 (see all 16)
    OriGene ORF clones in mouse, rat for TRIM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM6 (NM_014818)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM6

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM6
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM6 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM6


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA17156811

    TRIM6 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM6
    Interactions:

        Search GeneGlobe Interaction Network for TRIM6

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TRIM6 (Q9C0303 ENSP000003694404) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM28Q132633, ENSP000002530244I2D: score=1 STRING: ENSP00000253024
    TRIM23P364063, ENSP000002315244I2D: score=1 STRING: ENSP00000231524
    TRIM5ENSP000003693734STRING: ENSP00000369373
    UBE2HENSP000003478364STRING: ENSP00000347836
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070206protein trimerization IDA17156811

    TRIM6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM6



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRIM6 gene (4 alternative transcripts): 
    NM_001003818.2  NM_001198644.1  NM_001198645.1  NM_058166.4  

    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000278302(uc009yeo.2 uc010qzj.2 uc001mbc.2) ENST00000424369
    ENST00000507320 ENST00000380107 ENST00000511284 ENST00000380097(uc001mbe.3 uc001mbd.3 uc010qzk.2 uc010qzl.2)
    ENST00000445329(uc009yep.1) ENST00000515022 ENST00000506134 ENST00000469187
    ENST00000481603
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM6 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate TRIM6:
    hsa-miR-205* hsa-miR-33b hsa-miR-33a
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM6
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM6
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM6 (see all 16)
    OriGene ORF clones in mouse, rat for TRIM6
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM6 (NM_014818)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM6
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM6
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM6
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM6
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM6
      QuantiFast Probe-based Assays in human, mouse, rat TRIM6

    Selected AceView cDNA sequences (see all 143):

    NM_001003818 AK023210 AA625445 AA588100 AI650537 CR624250 BM989990 BE873135 
    AV661318 BE501740 AW612116 NM_001003827 AI650258 AA227117 BE503226 NM_021616 
    NM_058166 NM_130389 BE669989 AA769791 BE222316 AI628362 BX503815 BE220093 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6 (see all 9)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
    SP1:                                                                                      -                                             
    SP2:                                                                          -     -     -                                             
    SP3:        -     -                                                                                                                     
    SP4:                                                                                      -                                             
    SP5:                                                                                                                                    


    ECgene alternative splicing isoforms for TRIM6

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRIM6 expression in normal human tissues (normalized intensities)      TRIM6 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTGCTAAAA
    TRIM6 Expression
    About this image


    TRIM6 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epiblast (Early Embryonic Tissues)
             Epiblast Stem Cell line 5
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Kidney (Urinary System)
    TRIM6 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM6 Protein Expression
        Custom PCR Arrays for TRIM6
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM6
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM6
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM6
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM6
    QuantiFast Probe-based Assays in human, mouse, rat TRIM6
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM6

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM6 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim61 , 5 tripartite motif-containing 61, 5 81.63(n)1
    80.12(a)1
      7 (55.55 cM)5
    940881  NM_001013616.21  NP_001013637.11 
     1042187935 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    33(a)
    1 → many
    19(353752-359048) ENSGALG00000000865
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    33(a)
    1 → many
    GL343252.1(1250717-1269864)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia AL895251.22   -- 74.12(n)    AL895251.2 


    ENSEMBL Gene Tree for TRIM6 (if available)
    TreeFam Gene Tree for TRIM6 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRIM6 gene
    TRIM72  TRIM42  TRIM392  TRIM342  TRIML12  TRIM272  TRIM582  TRIM682  
    TRIM602  TRIM222  TRIM172  TRIM52  TRIM6-TRIM342  TRIM212  TRIM382  TRIM112  
    TRIM39-RPP212  
    Selected SIMAP similar genes for TRIM6 using alignment to 4 protein entries:     TRIM6_HUMAN (see all proteins) (see all similar genes):
    DKFZp781D1977    TRIM5    TRIM6-TRIM34    TRIM34    TRIM22    TRIM64C
    TRIM41    TRIM21    TRIM68    DKFZp686F23130    TRIM38    TRIM39
    TRIM58    TRIM11    TRIM4    MEFV    TRIM60    BT3.3

    TRIM6 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRIM6 (see all 16)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs44305461,2
    C,H--5615347(+) ATTATA/GTGGTA 1 -- us2k113Minor allele frequency- G:0.00NA WA CSA EA 376
    rs1910755911,2
    --5615377(+) GAGACA/CCCTTG 1 -- us2k10--------
    rs1828619381,2
    --5615386(+) TGAATC/TATTGC 1 -- us2k10--------
    rs1882169001,2
    --5615486(+) TAGCAA/CACAAA 1 -- us2k10--------
    rs1919629661,2
    --5615582(+) GCCCAC/GGCTAG 1 -- us2k10--------
    rs1506110531,2
    --5615687(+) GGCACA/GTACCG 1 -- us2k10--------
    rs71030761,2
    C,F,A,H--5615710(+) ATTTAT/CTTATT 1 -- us2k1 tfbs313Minor allele frequency- C:0.47NA WA CSA EA 380
    rs71221211,2
    C,H--5615762(+) AAAATC/TGTGGA 1 -- us2k113Minor allele frequency- T:0.00NA WA CSA EA 376
    rs1397004881,2
    C--5615817(+) CAAGCA/GAGCCA 1 -- us2k10--------
    rs578563281,2,4
    ----see VAR_0618232 mis40--------

    HapMap Linkage Disequilibrium report for TRIM6 (5617331 - 5634188 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TRIM6:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2658921CNV Deletion23128226
    nsv471746CNV Loss16327809
    nsv896947CNV Loss21882294
    nsv896939CNV Loss21882294
    nsv896946CNV Loss21882294
    dgv1027n71CNV Loss21882294
    nsv896945CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM6
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM6

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607564    OMIM disorders: --


    TRIM6 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TRIM6

    Export disorders for TRIM6 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRIM6 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TRIM6)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (EMBO J. 2001)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Molecular cloning of ring finger protein 21 (RNF21)/interferon- responsive finger protein (ifp1), which possesses two RING-B box- coiled coil domains in tandem. (PubMed id 11013086)1, 2 Orimo A.... Muramatsu M. (Genomics 2000)
    5. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. (PubMed id 18159944)1, 9 Sawyer S.L....Malik H.S. (PLoS Pathog. 2007)
    6. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PubMed id 16775307)1, 9 Li X....Sodroski J. (J. Virol. 2006)
    7. Unique features of TRIM5alpha among closely related human TRIM family members. (PubMed id 17156811)1, 9 Li X....Sodroski J. (Virology 2007)
    8. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    9. TRIM6 interacts with Myc and maintains the pluripotency of mouse embryonic stem cells. (PubMed id 22328504)1 Sato T....Hatakeyama S. (J. Cell. Sci. 2012)
    10. Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. (PubMed id 21680743)1 Li X....Sodroski J. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 117854 HGNC: 16277 AceView: TRIM34andTRIM6 Ensembl:ENSG00000121236 euGenes: HUgn117854
    ECgene: TRIM6 H-InvDB: TRIM6

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRIM6 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRIM6 gene:
    Search GeneIP for patents involving TRIM6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRIM6   OriGene RNAi products in human, mouse, rat for TRIM6  
     OriGene qPCR primer pairs and template standards for TRIM6   OriGene Protein Over-expression Lysate for TRIM6  
     OriGene MassSpec something-or-other for TRIM6   OriGene clones in human, mouse for TRIM6  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM6   OriGene Purified Protein for TRIM6  
     OriGene ORF clones in mouse, rat for TRIM6   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM6   OriGene Custom Protein Services for TRIM6  

     
     
     Block miRNA regulation of human, mouse, rat TRIM6 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRIM6
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM6 Predesigned siRNA for gene silencing in human, mouse, rat TRIM6
     QuantiFast Probe-based Assays in human, mouse, rat TRIM6 QuantiTect SYBR Green Assays in human, mouse, rat TRIM6
     Custom PCR Arrays for TRIM6 Search Chromatin IP Primers for TRIM6
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM6  Search GeneGlobe Interaction Network for TRIM6
     Regulatory tfbs in TRIM6 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRIM6 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM6
     GenScript Custom Assay Services for TRIM6 GenScript Custom overexpressing Cell Line Services for TRIM6
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRIM6
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRIM6 antibodies
     TRIM6 proteins
     TRIM6 lysates
     Antibodies for TRIM6
     See all of Abcam's Antibodies, Kits and Proteins for TRIM6
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRIM6
     Antibodies for TRIM6
     ELISAs for TRIM6
     CLIAs for TRIM6



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM6
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM6
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TRIM6
     Browse SwitchGear Promoter luciferase reporter plasmids for TRIM6
     Search ThermoFisher Antibodies for TRIM6
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM6
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM6
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM6
     LSBio Antibodies in human, mouse, rat for TRIM6
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM6 gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356980-web2.xennexinc.com index build: 126 solr: 1.4