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Aliases for TRIM6 Gene

Aliases for TRIM6 Gene

  • Tripartite Motif Containing 6 2 3
  • Tripartite Motif-Containing 6 2 3
  • RING Finger Protein 89 3 4
  • RNF89 3 4
  • Tripartite Motif-Containing Protein 6 3
  • EC 6.3.2 63

External Ids for TRIM6 Gene

Previous GeneCards Identifiers for TRIM6 Gene

  • GC11P006365
  • GC11P005919
  • GC11P005576
  • GC11P005581
  • GC11P005573
  • GC11P005276

Summaries for TRIM6 Gene

Entrez Gene Summary for TRIM6 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]

GeneCards Summary for TRIM6 Gene

TRIM6 (Tripartite Motif Containing 6) is a Protein Coding gene. An important paralog of this gene is TRIM58.

Gene Wiki entry for TRIM6 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM6 Gene

Genomics for TRIM6 Gene

Regulatory Elements for TRIM6 Gene

Genomic Location for TRIM6 Gene

5,596,101 bp from pter
5,612,958 bp from pter
16,858 bases
Plus strand

Genomic View for TRIM6 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM6 Gene

Proteins for TRIM6 Gene

  • Protein details for TRIM6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 6
    Protein Accession:
    Secondary Accessions:
    • A8K2A7
    • B4DDQ5
    • Q86WZ8
    • Q9HCR1

    Protein attributes for TRIM6 Gene

    488 amino acids
    Molecular mass:
    56400 Da
    Quaternary structure:
    • Homomultimer.
    • Sequence=BAB17050.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The in vivo relevance of this transcript of the TRIM34 (AC Q9BYJ4) and TRIM6 genes that codes for a chimeric protein of 842 residues is uncertain.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM6 Gene


neXtProt entry for TRIM6 Gene

Proteomics data for TRIM6 Gene at MOPED

Selected DME Specific Peptides for TRIM6 Gene

Post-translational modifications for TRIM6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

Domains for TRIM6 Gene

Gene Families for TRIM6 Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry



  • Q9C030
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM6: view

Function for TRIM6 Gene

Enzyme Numbers (IUBMB) for TRIM6 Gene

Gene Ontology (GO) - Molecular Function for TRIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM6: view

Animal Model Products

miRNA for TRIM6 Gene

miRTarBase miRNAs that target TRIM6

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM6

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM6 Gene

Localization for TRIM6 Gene

Subcellular locations from

Jensen Localization Image for TRIM6 Gene COMPARTMENTS Subcellular localization image for TRIM6 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IDA 17156811
genes like me logo Genes that share ontologies with TRIM6: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM6 Gene

Pathways for TRIM6 Gene

SuperPathways for TRIM6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070206 protein trimerization IDA 17156811
genes like me logo Genes that share ontologies with TRIM6: view

No data available for Pathways by source for TRIM6 Gene

Transcripts for TRIM6 Gene

Unigene Clusters for TRIM6 Gene

Tripartite motif containing 6:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM6

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15 ^ 16
SP1: -
SP2: - - -
SP3: - -
SP4: -
SP6: -

Relevant External Links for TRIM6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM6 Gene

mRNA expression in normal human tissues for TRIM6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM6 Gene

This gene is overexpressed in Kidney - Cortex (9.4).

Protein differential expression in normal tissues for TRIM6 Gene

This gene is overexpressed in Bone marrow stromal cell (20.3), Breast (18.4), Uterus (13.1), and Urine (8.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TRIM6 Gene

SOURCE GeneReport for Unigene cluster for TRIM6 Gene Hs.729048

genes like me logo Genes that share expressions with TRIM6: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt and Expression partners for TRIM6 Gene

Orthologs for TRIM6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM6 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM6 35
  • 84.94 (n)
  • 83.37 (a)
-- 36
  • 43 (a)
(Canis familiaris)
Mammalia TRIM6 35
  • 86.17 (n)
  • 83.16 (a)
(Mus musculus)
Mammalia Trim6 35
  • 81.63 (n)
  • 80.12 (a)
Trim6 16
Trim6 36
  • 80 (a)
(Pan troglodytes)
Mammalia TRIM6 35
  • 99.25 (n)
  • 98.98 (a)
TRIM6 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim6 35
  • 81.83 (n)
  • 81.15 (a)
(Gallus gallus)
Aves -- 36
  • 33 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 33 (a)
Species with no ortholog for TRIM6:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM6 Gene

Gene Tree for TRIM6 (if available)
Gene Tree for TRIM6 (if available)

Paralogs for TRIM6 Gene

genes like me logo Genes that share paralogs with TRIM6: view

Variants for TRIM6 Gene

Sequence variations from dbSNP and Humsavar for TRIM6 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
VAR_061823 -

Structural Variations from Database of Genomic Variants (DGV) for TRIM6 Gene

Variant ID Type Subtype PubMed ID
nsv896939 CNV Loss 21882294
dgv1027n71 CNV Loss 21882294
nsv896945 CNV Loss 21882294
nsv896946 CNV Loss 21882294
nsv471746 CNV Loss 16327809
esv2658921 CNV Deletion 23128226
nsv896947 CNV Loss 21882294

Relevant External Links for TRIM6 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM6 Gene

Disorders for TRIM6 Gene

Relevant External Links for TRIM6

Genetic Association Database (GAD)

No disorders were found for TRIM6 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for TRIM6 Gene

Publications for TRIM6 Gene

  1. The tripartite motif family identifies cell compartments. (PMID: 11331580) Reymond A. … Ballabio A. (EMBO J. 2001) 2 3 4
  2. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. (PMID: 16775307) Li X. … Sodroski J. (J. Virol. 2006) 3 23
  3. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X. … Sodroski J. (Virology 2007) 3 23
  4. Discordant evolution of the adjacent antiretroviral genes TRIM22 and TRIM5 in mammals. (PMID: 18159944) Sawyer S.L. … Malik H.S. (PLoS Pathog. 2007) 3 23
  5. Molecular cloning of ring finger protein 21 (RNF21)/interferon- responsive finger protein (ifp1), which possesses two RING-B box- coiled coil domains in tandem. (PMID: 11013086) Orimo A. … Muramatsu M. (Genomics 2000) 3 4

Products for TRIM6 Gene

Sources for TRIM6 Gene

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