Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRIM59 Gene

protein-coding   GIFtS: 47
GCID: GC03M160153

Tripartite Motif Containing 59

(Previous names: tripartite motif-containing 57, tripartite motif-containing...)
(Previous symbol: TRIM57)
  Try our

disease database 

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tripartite Motif Containing 591 2     TSBF12 3
TRIM571 2 3     RING Finger Protein 1042 3
Tripartite Motif-Containing 571 2     MRF12
Tripartite Motif-Containing 591 2     Tripartite Motif-Containing Protein 592
Tumor Suppressor TSBF-12 3     Tumor Suppressor TSBF12
RNF1042 3     

External Ids:    HGNC: 308341   Entrez Gene: 2868272   Ensembl: ENSG000002131867   UniProtKB: Q8IWR13   

Export aliases for TRIM59 gene to outside databases

Previous GC identifers: GC03M161637 GC03M161427 GC03M157551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

GeneCards Summary for TRIM59 Gene:
TRIM59 (tripartite motif containing 59) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is TRIM13.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_005612.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM59 gene promoter:
         GR   Max1   NRSF form 1   NRSF form 2   Tal-1beta   Gfi-1   E47   POU2F1   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM59 promoter sequence
   Search Chromatin IP Primers for TRIM59

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM59


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q25.33   Ensembl cytogenetic band:  3q25.33   HGNC cytogenetic band: 3q26

TRIM59 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM59 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M160153:  view genomic region     (about GC identifiers)

Start:
160,150,233 bp from pter      End:
160,203,561 bp from pter
Size:
53,329 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRI59_HUMAN, Q8IWR1 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 59  
Size: 403 amino acids; 47114 Da
Secondary accessions: A8K5G9 D3DNL9

Explore the universe of human proteins at neXtProt for TRIM59: NX_Q8IWR1

Explore proteomics data for TRIM59 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM59 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_775107.1  
    ENSEMBL proteins: 
     ENSP00000311219   ENSP00000417081   ENSP00000420520   ENSP00000418856   ENSP00000418699  
     ENSP00000417605   ENSP00000420451   ENSP00000444313  

    TRIM59 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM59
    GenScript Custom Purified and Recombinant Proteins Services for TRIM59
    Novus Biologicals TRIM59 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM59

     
    Search eBioscience for Proteins for TRIM59 

     
    antibodies-online proteins for TRIM59 (2 products) 

     
    antibodies-online peptides for TRIM59

    TRIM59 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRIM59
    OriGene Custom Antibody Services for TRIM59
    Novus Biologicals TRIM59 Antibodies
    Abcam antibodies for TRIM59
    Cloud-Clone Corp. Antibodies for TRIM59
    Search ThermoFisher Antibodies for TRIM59
    antibodies-online antibodies for TRIM59 (25 products) 

    TRIM59 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM59
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM59
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM59
    Cloud-Clone Corp. CLIAs for TRIM59
    Search eBioscience for ELISAs for TRIM59 
    antibodies-online kits for TRIM59 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    4 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR000315 Znf_B-box
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q8IWR1

    ProtoNet protein and cluster: Q8IWR1

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI59_HUMAN, Q8IWR1
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM59           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity IEA--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    Find genes that share ontologies with TRIM59           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for TRIM59:
     Increased S DNA content  Increased circadian period len 

         1 MGI phenotypic allele for Trim59 (no phenotypes)

    Find genes that share phenotypes with TRIM59           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TRIM59

    miRNA
    Products:
        
    miRTarBase miRNAs that target TRIM59:
    hsa-mir-21-5p (MIRT030898), hsa-mir-130b-3p (MIRT020309), hsa-mir-769-5p (MIRT039191), hsa-mir-30b-5p (MIRT046150), hsa-mir-192-5p (MIRT026539), hsa-mir-148a-3p (MIRT025996), hsa-mir-19b-3p (MIRT031165), hsa-mir-215-5p (MIRT024373)

    Block miRNA regulation of human, mouse, rat TRIM59 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM59 (see all 10):
    hsa-miR-875-3p hsa-miR-2278 hsa-let-7a-2* hsa-miR-3133 hsa-miR-335 hsa-miR-499-5p hsa-miR-891b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidTRIM59 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM59
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM59

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM59

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM59 (see all 5)
    OriGene ORF clones in mouse, rat for TRIM59
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM59 (NM_173084)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM59
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM59

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM59
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM59 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM59


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRI59_HUMAN, Q8IWR1: Membrane; Single-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    endoplasmic reticulum2
    cytoskeleton1
    cytosol1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005783endoplasmic reticulum IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TRIM59           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM59
    Interactions:

        Search GeneGlobe Interaction Network for TRIM59

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for TRIM59 (Q8IWR13 ENSP000003112194) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ESR2Q927313, ENSP000003439254I2D: score=1 STRING: ENSP00000343925
    ESR1P033723, ENSP000002062494I2D: score=1 STRING: ENSP00000206249
    C3ENSP000002459074STRING: ENSP00000245907
    UBCENSP000003448184STRING: ENSP00000344818
    BIRC5ENSP000003016334STRING: ENSP00000301633
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016567protein ubiquitination ----
    GO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling IMP--

    Find genes that share ontologies with TRIM59           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM59 (TRI59)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRIM59 gene: 
    NM_173084.2  

    Unigene Cluster for TRIM59:

    Tripartite motif containing 59
    Hs.212957  [show with all ESTs]
    Unigene Representative Sequence: BX537987
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309784(uc003fdm.3) ENST00000479460 ENST00000471396 ENST00000496222
    ENST00000471155 ENST00000494486 ENST00000468542 ENST00000543469
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM59 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM59 (see all 10):
    hsa-miR-875-3p hsa-miR-2278 hsa-let-7a-2* hsa-miR-3133 hsa-miR-335 hsa-miR-499-5p hsa-miR-891b hsa-let-7g*
    SwitchGear 3'UTR luciferase reporter plasmidTRIM59 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM59
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM59
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM59 (see all 5)
    OriGene ORF clones in mouse, rat for TRIM59
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM59 (NM_173084)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM59
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM59
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM59
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM59
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM59
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM59
      QuantiFast Probe-based Assays in human, mouse, rat TRIM59

    Additional mRNA sequence: 

    AK291284.1 BC109259.1 BC109260.1 BX537987.1 

    16 DOTS entries:

    DT.99955215  DT.91696715  DT.92418424  DT.414134  DT.120858692  DT.75102073  DT.100828674  DT.121643345 
    DT.454896  DT.40258869  DT.100828682  DT.120858680  DT.120858681  DT.100828676  DT.120858489  DT.95140869 

    Selected AceView cDNA sequences (see all 242):

    AL601983 AV709486 AI287883 AI672401 BI826192 AA904964 CA397010 AA353809 
    BX496497 BM461402 BX486855 NM_173084 AI215011 NM_020800 AY159379 AW504973 
    D16989 AI033851 AA699513 CA389016 AA629865 CA313742 BC068444 BF512700 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRIM59 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATATAGTTG
    TRIM59 Expression
    About this image


    TRIM59 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 2 entries
             Primordial Germ Cells Primitive Gonad
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Limb (Muscoskeletal System)
             Limb Bud
     
     Ovary (Reproductive System)
             Secondary Oocyte Antral Follicle
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
    TRIM59 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM59 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.212957
        Custom PCR Arrays for TRIM59
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM59
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM59
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM59
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM59
    QuantiFast Probe-based Assays in human, mouse, rat TRIM59
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM59

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM59 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim591 , 5 tripartite motif-containing 591, 5 85.74(n)1
    82.84(a)1
      3 (32.16 cM)5
    669491  NM_025863.31  NP_080139.31 
     690352885 
    chicken
    (Gallus gallus)
    Aves TRIM591 tripartite motif containing 59 65.42(n)
    59.1(a)
      425013  NM_001031320.1  NP_001026491.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM596
    tripartite motif containing 59
    57(a)
    1 ↔ 1
    3(12990790-12992010)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia trim591 tripartite motif containing 59 55.18(n)
    43.78(a)
      100493536  XM_002933236.2  XP_002933282.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1000069711 tripartite motif-containing protein 59-like 51.12(n)
    47.92(a)
      100006971  XM_001345519.2  XP_001345555.1 


    ENSEMBL Gene Tree for TRIM59 (if available)
    TreeFam Gene Tree for TRIM59 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRIM59 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM92  TRIM672  TRIM362  TRIM552  
    MID12  MID22  TRIM542  FSD12  
    15 SIMAP similar genes for TRIM59 using alignment to 8 protein entries:     TRI59_HUMAN (see all proteins):
    IFT80    DKFZp686N1030    TRIM67    LONRF1    ANKIB1    RNF151
    TRIM13    TRIM36    RFWD2    TRIM73    SH3RF1    TRIM17
    TRIM26    LNX1    RNF138

    Find genes that share paralogs with TRIM59           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRIM59 (see all 320)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838908161,2
    --160153303(+) TCAAAA/GGAAGT 1 -- ut310--------
    rs76291,2
    C,F,A,H--160153305(+) AAAAGA/GAGTTT 1 -- ut3119Minor allele frequency- G:0.45MN EA NS NA WA CSA 2297
    rs1402785361,2
    --160153311(+) AGTTTA/GTTAAA 1 -- ut310--------
    rs1452724861,2
    --160153313(+) TTTATC/TAAAAT 1 -- ut310--------
    rs1378944121,2
    --160153421(+) AAGAAC/GCAGTT 1 -- ut310--------
    rs1407597711,2
    --160153516(+) AAAATG/TATATA 1 -- ut310--------
    rs31804111,2
    C,F--160153601(-) CATGCT/CATCAC 1 -- ut312Minor allele frequency- C:0.01MN WA 302
    rs1411424621,2
    C--160153689(+) CAAAA-/AGGGGGT 1 -- ut310--------
    rs2009629551,2
    C--160153690(-) ACCCCC/TTTTTT 1 -- ut310--------
    rs1502861351,2
    C--160153789(+) GGCAC-/TTTTATG 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TRIM59 (160150233 - 160203561 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TRIM59:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822306CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM59
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM59

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRIM59 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TRIM59)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PubMed id 12095697)1, 3 Chang R....Li M.D. (Gene 2002)
    3. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    4. TRIM59 interacts with ECSIT and negatively regulates NF-I_B and IRF-3/7-mediated signal pathways. (PubMed id 22588174)1 Kondo T....Hatakeyama S. (Biochem. Biophys. Res. Commun. 2012)
    5. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    6. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (amp 2011)
    7. Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha. (PubMed id 15941852)1 Georgescu S.P....Mendelsohn M.E. (Mol. Endocrinol. 2005)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    10. (PubMed id )2 

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 286827 HGNC: 30834 AceView: KIAA1374andTRIM59 Ensembl:ENSG00000213186 euGenes: HUgn286827
    ECgene: TRIM59 H-InvDB: TRIM59

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRIM59 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM59 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRIM59 gene:
    Search GeneIP for patents involving TRIM59

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRIM59   OriGene RNAi products in human, mouse, rat for TRIM59  
     OriGene qPCR primer pairs and template standards for TRIM59   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRIM59  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM59   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for TRIM59   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM59   OriGene Custom Protein Services for TRIM59  

     
     
     Block miRNA regulation of human, mouse, rat TRIM59 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRIM59
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM59 Predesigned siRNA for gene silencing in human, mouse, rat TRIM59
     QuantiFast Probe-based Assays in human, mouse, rat TRIM59 QuantiTect SYBR Green Assays in human, mouse, rat TRIM59
     Custom PCR Arrays for TRIM59 Search Chromatin IP Primers for TRIM59
     Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM59  Search GeneGlobe Interaction Network for TRIM59
     Regulatory tfbs in TRIM59 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRIM59 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM59
     GenScript Custom Assay Services for TRIM59 GenScript Custom overexpressing Cell Line Services for TRIM59
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRIM59 (TRI59)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRIM59 antibodies
     TRIM59 proteins
     Antibodies for TRIM59
     See all of Abcam's Antibodies, Kits and Proteins for TRIM59
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRIM59
     Antibodies for TRIM59
     ELISAs for TRIM59
     CLIAs for TRIM59



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM59
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM59
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM59
     SwitchGear Promoter luciferase reporter plasmids for TRIM59
     Search ThermoFisher Antibodies for TRIM59
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM59
     Browse compounds at ApexBio
     Search Addgene for plasmids for TRIM59
      Search eBioscience for proteins for TRIM59
      Search eBioscience for elisas for TRIM59
      eBioscience FlowRNA Probe Sets
     genOway: Develop your customized and physiologically relevant rodent model for TRIM59
     antibodies-online antibodies for TRIM59 (25 products)
     antibodies-online kits for TRIM59 (6 products)
     antibodies-online peptides for TRIM59
     antibodies-online proteins for TRIM59 (2 products)
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014 , 7 Oct 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM59 gene at Home site.
    Version: 3.12.258 10 Dec 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4