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Aliases for TRIM59 Gene

Aliases for TRIM59 Gene

  • Tripartite Motif Containing 59 2 3 5
  • Tripartite Motif-Containing 57 2 3
  • Tumor Suppressor TSBF-1 3 4
  • RING Finger Protein 104 3 4
  • TRIM57 3 4
  • RNF104 3 4
  • TSBF1 3 4
  • Tripartite Motif-Containing Protein 59 3
  • Tripartite Motif-Containing 59 2
  • Tumor Suppressor TSBF1 3
  • IFT80L 3
  • MRF1 3

External Ids for TRIM59 Gene

Previous HGNC Symbols for TRIM59 Gene

  • TRIM57

Previous GeneCards Identifiers for TRIM59 Gene

  • GC03M161637
  • GC03M161427
  • GC03M160153
  • GC03M157551

Summaries for TRIM59 Gene

GeneCards Summary for TRIM59 Gene

TRIM59 (Tripartite Motif Containing 59) is a Protein Coding gene. Diseases associated with TRIM59 include Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot for TRIM59 Gene

  • May serve as a multifunctional regulator for innate immune signaling pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM59 Gene

Genomics for TRIM59 Gene

Regulatory Elements for TRIM59 Gene

Enhancers for TRIM59 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03F160446 1.4 Ensembl ENCODE 12.4 +36.4 36434 5.5 CREB3L1 WRNIP1 ARID4B SIN3A ZNF2 CBX5 ZNF207 ZNF143 FOS KLF13 B3GAT3P1 TRIM59 SCARNA7 RPL23AP42 SMC4 ENSG00000248710 GC03P160411
GH03F160452 0.4 Ensembl 12.4 +33.3 33273 0.2 ZBTB33 TRIM59 SCARNA7 IFT80 GC03P160454 GC03P160455 PIR52189 B3GAT3P1
GH03F160460 0.4 FANTOM5 11.7 +25.5 25507 0.2 ZFP64 TRIM59 SCARNA7 GC03P160454 GC03P160455 PIR52189 GC03M160475
GH03F160506 1 ENCODE 0.3 -21.7 -21657 1.5 ATF1 CREB3L1 ARID4B SIN3A GLIS2 ZNF263 SP3 SP5 REST SMARCA4 GC03M160515 SCARNA7 TRIM59
GH03F160472 0.6 ENCODE 0.4 +11.8 11793 2.4 CTCF JUND IKZF1 MAFG SIN3A EMSY MAFK B3GAT3P1 RNU7-136P TRIM59
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM59 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001854415 -127 1001 CTCF ZBTB33 REST RAD21

Genomic Location for TRIM59 Gene

Chromosome:
3
Start:
160,432,445 bp from pter
End:
160,485,773 bp from pter
Size:
53,329 bases
Orientation:
Minus strand

Genomic View for TRIM59 Gene

Genes around TRIM59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM59 Gene

Proteins for TRIM59 Gene

  • Protein details for TRIM59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWR1-TRI59_HUMAN
    Recommended name:
    Tripartite motif-containing protein 59
    Protein Accession:
    Q8IWR1
    Secondary Accessions:
    • A8K5G9
    • D3DNL9

    Protein attributes for TRIM59 Gene

    Size:
    403 amino acids
    Molecular mass:
    47114 Da
    Quaternary structure:
    • Interacts with ECSIT.

    Alternative splice isoforms for TRIM59 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM59 Gene

Post-translational modifications for TRIM59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM59 Gene

Domains & Families for TRIM59 Gene

Gene Families for TRIM59 Gene

Suggested Antigen Peptide Sequences for TRIM59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWR1

UniProtKB/Swiss-Prot:

TRI59_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM59: view

Function for TRIM59 Gene

Molecular function for TRIM59 Gene

UniProtKB/Swiss-Prot Function:
May serve as a multifunctional regulator for innate immune signaling pathways.

Gene Ontology (GO) - Molecular Function for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
GO:0061630 ubiquitin protein ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM59: view
genes like me logo Genes that share phenotypes with TRIM59: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM59

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM59 Gene

Localization for TRIM59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM59 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM59 gene
Compartment Confidence
endoplasmic reticulum 4
cytoskeleton 3
nucleus 3
extracellular 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005813 centrosome IBA --
GO:0005929 cilium IBA --
genes like me logo Genes that share ontologies with TRIM59: view

Pathways & Interactions for TRIM59 Gene

SuperPathways for TRIM59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP 22588174
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
genes like me logo Genes that share ontologies with TRIM59: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM59 Gene

Transcripts for TRIM59 Gene

Unigene Clusters for TRIM59 Gene

Tripartite motif containing 59:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM59 Gene

No ASD Table

Relevant External Links for TRIM59 Gene

GeneLoc Exon Structure for
TRIM59
ECgene alternative splicing isoforms for
TRIM59

Expression for TRIM59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM59 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2) and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TRIM59 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM59 Gene



Protein tissue co-expression partners for TRIM59 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM59 Gene:

TRIM59

SOURCE GeneReport for Unigene cluster for TRIM59 Gene:

Hs.212957
genes like me logo Genes that share expression patterns with TRIM59: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM59 Gene

Orthologs for TRIM59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM59 34
  • 99.09 (n)
cow
(Bos Taurus)
Mammalia TRIM59 34
  • 90.95 (n)
MGC137058 35
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM59 34 35
  • 90.94 (n)
rat
(Rattus norvegicus)
Mammalia Trim59 34
  • 87.06 (n)
mouse
(Mus musculus)
Mammalia Trim59 34 16 35
  • 85.74 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 65 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
-- 35
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM59 35
  • 62 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM59 34 35
  • 65.42 (n)
lizard
(Anolis carolinensis)
Reptilia TRIM59 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim59 34
  • 55.18 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100006971 34
  • 51.12 (n)
TRIM59 35
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToMany
Species where no ortholog for TRIM59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM59 Gene

ENSEMBL:
Gene Tree for TRIM59 (if available)
TreeFam:
Gene Tree for TRIM59 (if available)

Paralogs for TRIM59 Gene

genes like me logo Genes that share paralogs with TRIM59: view

Variants for TRIM59 Gene

Sequence variations from dbSNP and Humsavar for TRIM59 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs1047210 -- 160,436,470(-) TTAAA(G/T)CAAAG utr-variant-3-prime
rs111268505 -- 160,450,249(+) GGGGC(C/T)TCCTG upstream-variant-2KB
rs111310836 -- 160,436,627(+) CCCCA(C/T)CTCTA utr-variant-3-prime
rs111476355 -- 160,438,735(+) ACTGT(C/T)CAAGC reference, missense
rs112024372 -- 160,449,952(+) TAAAC(A/G)GTGGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM59 Gene

Variant ID Type Subtype PubMed ID
esv3598384 CNV loss 21293372
nsv822306 CNV gain 20364138

Variation tolerance for TRIM59 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM59 Gene

Disorders for TRIM59 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM59 Gene - From: DISEASES

Disorder Aliases PubMed IDs
short-rib thoracic dysplasia 1 with or without polydactyly
  • asphyxiating thoracic dystrophy
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM59
genes like me logo Genes that share disorders with TRIM59: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM59 Gene

Publications for TRIM59 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PMID: 12095697) Chang R. … Li M.D. (Gene 2002) 2 3 64
  3. PAK4 promotes kinase-independent stabilization of RhoU to modulate cell adhesion. (PMID: 26598620) Dart A.E. … Wells C.M. (J. Cell Biol. 2015) 3 64
  4. TRIM59 Promotes the Proliferation and Migration of Non-Small Cell Lung Cancer Cells by Upregulating Cell Cycle Related Proteins. (PMID: 26599082) Zhan W. … Wang J.B. (PLoS ONE 2015) 3 64
  5. TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. (PMID: 25046164) Zhou Z. … Gao W.Q. (Gastroenterology 2014) 3 64

Products for TRIM59 Gene

Sources for TRIM59 Gene

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