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Aliases for TRIM59 Gene

Aliases for TRIM59 Gene

  • Tripartite Motif Containing 59 2 3 5
  • Tripartite Motif-Containing 57 2 3
  • Tripartite Motif-Containing 59 2 3
  • Tumor Suppressor TSBF-1 3 4
  • RING Finger Protein 104 3 4
  • TRIM57 3 4
  • RNF104 3 4
  • TSBF1 3 4
  • Tumor Suppressor TSBF1 3
  • IFT80L 3
  • MRF1 3

External Ids for TRIM59 Gene

Previous HGNC Symbols for TRIM59 Gene

  • TRIM57

Previous GeneCards Identifiers for TRIM59 Gene

  • GC03M161637
  • GC03M161427
  • GC03M160153
  • GC03M157551

Summaries for TRIM59 Gene

GeneCards Summary for TRIM59 Gene

TRIM59 (Tripartite Motif Containing 59) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM59 Gene

  • May serve as a multifunctional regulator for innate immune signaling pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM59 Gene

Genomics for TRIM59 Gene

Regulatory Elements for TRIM59 Gene

Enhancers for TRIM59 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM59 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM59 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM59 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM59 Gene

160,432,445 bp from pter
160,485,773 bp from pter
53,329 bases
Minus strand

Genomic View for TRIM59 Gene

Genes around TRIM59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM59 Gene

Proteins for TRIM59 Gene

  • Protein details for TRIM59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 59
    Protein Accession:
    Secondary Accessions:
    • A8K5G9
    • D3DNL9

    Protein attributes for TRIM59 Gene

    403 amino acids
    Molecular mass:
    47114 Da
    Quaternary structure:
    • Interacts with ECSIT.

    Alternative splice isoforms for TRIM59 Gene


neXtProt entry for TRIM59 Gene

Proteomics data for TRIM59 Gene at MOPED

Post-translational modifications for TRIM59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM59 Gene

Domains & Families for TRIM59 Gene

Gene Families for TRIM59 Gene

Protein Domains for TRIM59 Gene

Suggested Antigen Peptide Sequences for TRIM59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM59: view

Function for TRIM59 Gene

Molecular function for TRIM59 Gene

UniProtKB/Swiss-Prot Function:
May serve as a multifunctional regulator for innate immune signaling pathways.
genes like me logo Genes that share phenotypes with TRIM59: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TRIM59

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM59 Gene

Localization for TRIM59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM59 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TRIM59 Gene COMPARTMENTS Subcellular localization image for TRIM59 gene
Compartment Confidence
endoplasmic reticulum 4
cytoskeleton 3
nucleus 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0005929 cilium IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRIM59: view

Pathways & Interactions for TRIM59 Gene

SuperPathways for TRIM59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM59 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM59 Gene

Drugs & Compounds for TRIM59 Gene

No Compound Related Data Available

Transcripts for TRIM59 Gene

Unigene Clusters for TRIM59 Gene

Tripartite motif containing 59:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM59 Gene

No ASD Table

Relevant External Links for TRIM59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM59 Gene

mRNA expression in normal human tissues for TRIM59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM59 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x6.2) and Brain - Substantia nigra (x5.4).

Protein differential expression in normal tissues from HIPED for TRIM59 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM59 Gene

SOURCE GeneReport for Unigene cluster for TRIM59 Gene Hs.212957

genes like me logo Genes that share expression patterns with TRIM59: view

Protein tissue co-expression partners for TRIM59 Gene

- Elite partner

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for TRIM59 Gene

Orthologs for TRIM59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM59 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM59 35
  • 90.95 (n)
  • 89.75 (a)
MGC137058 36
  • 90 (a)
(Canis familiaris)
Mammalia TRIM59 35
  • 90.94 (n)
  • 88.78 (a)
TRIM59 36
  • 88 (a)
(Mus musculus)
Mammalia Trim59 35
  • 85.74 (n)
  • 82.84 (a)
Trim59 16
Trim59 36
  • 83 (a)
(Pan troglodytes)
Mammalia TRIM59 35
  • 99.09 (n)
  • 98.5 (a)
(Rattus norvegicus)
Mammalia Trim59 35
  • 87.06 (n)
  • 84.08 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
-- 36
  • 59 (a)
-- 36
  • 62 (a)
-- 36
  • 59 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM59 36
  • 62 (a)
(Gallus gallus)
Aves TRIM59 35
  • 65.42 (n)
  • 59.1 (a)
TRIM59 36
  • 58 (a)
(Anolis carolinensis)
Reptilia TRIM59 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim59 35
  • 55.18 (n)
  • 43.78 (a)
(Danio rerio)
Actinopterygii LOC100006971 35
  • 51.12 (n)
  • 47.92 (a)
TRIM59 36
  • 38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
Species with no ortholog for TRIM59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM59 Gene

Gene Tree for TRIM59 (if available)
Gene Tree for TRIM59 (if available)

Paralogs for TRIM59 Gene

genes like me logo Genes that share paralogs with TRIM59: view

Variants for TRIM59 Gene

Sequence variations from dbSNP and Humsavar for TRIM59 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs7629 -- 160,435,517(+) AAAAG(A/G/T)AGTTT utr-variant-3-prime
rs15470 -- 160,435,708(+) AGATA(C/T)AAAAT utr-variant-3-prime
rs1047210 -- 160,436,470(-) TTAAA(G/T)CAAAG utr-variant-3-prime
rs2279457 -- 160,450,504(+) TGGGT(A/G)GATCC upstream-variant-2KB
rs1129400 -- 160,436,544(-) tggga(C/T)tatag utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM59 Gene

Variant ID Type Subtype PubMed ID
nsv822306 CNV Gain 20364138

Variation tolerance for TRIM59 Gene

Residual Variation Intolerance Score: 88.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.43; 42.85% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM59 Gene

Disorders for TRIM59 Gene

Relevant External Links for TRIM59

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM59 Gene

Publications for TRIM59 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PMID: 12095697) Chang R. … Li M.D. (Gene 2002) 2 3
  3. TRIM59 is up-regulated in gastric tumors, promoting ubiquitination and degradation of p53. (PMID: 25046164) Zhou Z. … Gao W.Q. (Gastroenterology 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. TRIM59 interacts with ECSIT and negatively regulates NF-I_B and IRF-3/7-mediated signal pathways. (PMID: 22588174) Kondo T. … Hatakeyama S. (Biochem. Biophys. Res. Commun. 2012) 3

Products for TRIM59 Gene

Sources for TRIM59 Gene