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Aliases for TRIM59 Gene

Aliases for TRIM59 Gene

  • Tripartite Motif Containing 59 2 3
  • Tripartite Motif-Containing 57 2 3
  • Tripartite Motif-Containing 59 2 3
  • Tumor Suppressor TSBF-1 3 4
  • RING Finger Protein 104 3 4
  • TRIM57 3 4
  • RNF104 3 4
  • TSBF1 3 4
  • Tripartite Motif-Containing Protein 59 3
  • Tumor Suppressor TSBF1 3
  • IFT80L 3
  • MRF1 3

External Ids for TRIM59 Gene

Previous HGNC Symbols for TRIM59 Gene

  • TRIM57

Previous GeneCards Identifiers for TRIM59 Gene

  • GC03M161637
  • GC03M161427
  • GC03M160153
  • GC03M157551

Summaries for TRIM59 Gene

GeneCards Summary for TRIM59 Gene

TRIM59 (Tripartite Motif Containing 59) is a Protein Coding gene. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM59 Gene

  • May serve as a multifunctional regulator for innate immune signaling pathways.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM59 Gene

Genomics for TRIM59 Gene

Regulatory Elements for TRIM59 Gene

Genomic Location for TRIM59 Gene

Start:
160,432,445 bp from pter
End:
160,485,773 bp from pter
Size:
53,329 bases
Orientation:
Minus strand

Genomic View for TRIM59 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM59 Gene

Proteins for TRIM59 Gene

  • Protein details for TRIM59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWR1-TRI59_HUMAN
    Recommended name:
    Tripartite motif-containing protein 59
    Protein Accession:
    Q8IWR1
    Secondary Accessions:
    • A8K5G9
    • D3DNL9

    Protein attributes for TRIM59 Gene

    Size:
    403 amino acids
    Molecular mass:
    47114 Da
    Quaternary structure:
    • Interacts with ECSIT.

    Alternative splice isoforms for TRIM59 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM59 Gene

Proteomics data for TRIM59 Gene at MOPED

Post-translational modifications for TRIM59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM59 Gene

Domains for TRIM59 Gene

Gene Families for TRIM59 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM59 Gene

Suggested Antigen Peptide Sequences for TRIM59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWR1

UniProtKB/Swiss-Prot:

TRI59_HUMAN :
  • Q8IWR1
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM59: view

Function for TRIM59 Gene

Molecular function for TRIM59 Gene

UniProtKB/Swiss-Prot Function: May serve as a multifunctional regulator for innate immune signaling pathways.

Gene Ontology (GO) - Molecular Function for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM59: view

Phenotypes for TRIM59 Gene

GenomeRNAi human phenotypes for TRIM59:
genes like me logo Genes that share phenotypes with TRIM59: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TRIM59 Gene

Localization for TRIM59 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM59 Gene

Endoplasmic reticulum membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM59 Gene COMPARTMENTS Subcellular localization image for TRIM59 gene
Compartment Confidence
nucleus 3
endoplasmic reticulum 2
cytoskeleton 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005783 endoplasmic reticulum ISS --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TRIM59: view

Pathways for TRIM59 Gene

SuperPathways for TRIM59 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM59 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling IMP 22588174
GO:0045087 innate immune response IEA --
GO:0046597 negative regulation of viral entry into host cell IEA --
genes like me logo Genes that share ontologies with TRIM59: view

No data available for Pathways by source for TRIM59 Gene

Transcripts for TRIM59 Gene

mRNA/cDNA for TRIM59 Gene

Unigene Clusters for TRIM59 Gene

Tripartite motif containing 59:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM59

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM59 Gene

No ASD Table

Relevant External Links for TRIM59 Gene

GeneLoc Exon Structure for
TRIM59
ECgene alternative splicing isoforms for
TRIM59

Expression for TRIM59 Gene

mRNA expression in normal human tissues for TRIM59 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM59 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (6.2) and Brain - Substantia nigra (5.4).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM59 Gene

SOURCE GeneReport for Unigene cluster for TRIM59 Gene Hs.212957

mRNA Expression by UniProt/SwissProt for TRIM59 Gene

Q8IWR1-TRI59_HUMAN
Tissue specificity: Isoform IFT80-L is widely expressed.
genes like me logo Genes that share expressions with TRIM59: view

In Situ Assay Products

Orthologs for TRIM59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM59 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM59 35
  • 99.09 (n)
  • 98.5 (a)
cow
(Bos Taurus)
Mammalia MGC137058 36
  • 90 (a)
OneToOne
TRIM59 35
  • 90.95 (n)
  • 89.75 (a)
dog
(Canis familiaris)
Mammalia TRIM59 35
  • 90.94 (n)
  • 88.78 (a)
TRIM59 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim59 35
  • 85.74 (n)
  • 82.84 (a)
Trim59 16
Trim59 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 65 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 59 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM59 36
  • 62 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim59 35
  • 87.06 (n)
  • 84.08 (a)
chicken
(Gallus gallus)
Aves TRIM59 35
  • 65.42 (n)
  • 59.1 (a)
TRIM59 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM59 36
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia trim59 35
  • 55.18 (n)
  • 43.78 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100006971 35
  • 51.12 (n)
  • 47.92 (a)
TRIM59 36
  • 38 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToMany
Species with no ortholog for TRIM59:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM59 Gene

ENSEMBL:
Gene Tree for TRIM59 (if available)
TreeFam:
Gene Tree for TRIM59 (if available)

Paralogs for TRIM59 Gene

genes like me logo Genes that share paralogs with TRIM59: view

Variants for TRIM59 Gene

Sequence variations from dbSNP and Humsavar for TRIM59 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs7629 -- 160,435,517(+) AAAAG(A/G/T)AGTTT utr-variant-3-prime
rs15470 -- 160,435,708(+) AGATA(C/T)AAAAT utr-variant-3-prime
rs1047210 -- 160,436,470(-) TTAAA(G/T)CAAAG utr-variant-3-prime
rs1129400 -- 160,436,544(-) tggga(C/T)tatag utr-variant-3-prime
rs1141023 -- 160,439,163(-) GAAGA(A/G)TTAAC synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TRIM59 Gene

Variant ID Type Subtype PubMed ID
nsv822306 CNV Gain 20364138

Relevant External Links for TRIM59 Gene

HapMap Linkage Disequilibrium report
TRIM59

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM59 Gene

Disorders for TRIM59 Gene

No disorders were found for TRIM59 Gene.

No data available for UniProtKB/Swiss-Prot for TRIM59 Gene

Publications for TRIM59 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Molecular cloning, mapping and characterization of a novel mouse RING finger gene, Mrf1. (PMID: 12095697) Chang R. … Li M.D. (Gene 2002) 2 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  4. Modulator recognition factor 1, an AT-rich interaction domain family member, is a novel corepressor for estrogen receptor alpha. (PMID: 15941852) Georgescu S.P. … Mendelsohn M.E. (Mol. Endocrinol. 2005) 3
  5. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3

Products for TRIM59 Gene

Sources for TRIM59 Gene

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