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Aliases for TRIM58 Gene

Aliases for TRIM58 Gene

  • Tripartite Motif Containing 58 2 3
  • Tripartite Motif-Containing Protein 58 3 4
  • Tripartite Motif-Containing 58 2 3
  • Protein BIA2 4
  • EC 6.3.2.- 4
  • BIA2 3

External Ids for TRIM58 Gene

Previous GeneCards Identifiers for TRIM58 Gene

  • GC01P244347
  • GC01P246087
  • GC01P248020
  • GC01P218409

Summaries for TRIM58 Gene

GeneCards Summary for TRIM58 Gene

TRIM58 (Tripartite Motif Containing 58) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM21.

UniProtKB/Swiss-Prot for TRIM58 Gene

  • E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM58 Gene

Genomics for TRIM58 Gene

Regulatory Elements for TRIM58 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM58 Gene

Chromosome:
1
Start:
247,857,199 bp from pter
End:
247,880,138 bp from pter
Size:
22,940 bases
Orientation:
Plus strand

Genomic View for TRIM58 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TRIM58 Gene

Proteins for TRIM58 Gene

  • Protein details for TRIM58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG06-TRI58_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM58
    Protein Accession:
    Q8NG06
    Secondary Accessions:
    • Q6B0H9

    Protein attributes for TRIM58 Gene

    Size:
    486 amino acids
    Molecular mass:
    54766 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM63958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TRIM58 Gene

Proteomics data for TRIM58 Gene at MOPED

Post-translational modifications for TRIM58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM58 Gene

Domains & Families for TRIM58 Gene

Suggested Antigen Peptide Sequences for TRIM58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG06

UniProtKB/Swiss-Prot:

TRI58_HUMAN :
  • The RING finger is required for ubiquitin ligase activity.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • The RING finger is required for ubiquitin ligase activity.
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM58: view

Function for TRIM58 Gene

Molecular function for TRIM58 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

Enzyme Numbers (IUBMB) for TRIM58 Gene

Gene Ontology (GO) - Molecular Function for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM58: view

Phenotypes for TRIM58 Gene

genes like me logo Genes that share phenotypes with TRIM58: view

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM58 Gene

Localization for TRIM58 Gene

Gene Ontology (GO) - Cellular Components for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for TRIM58 Gene

Pathways & Interactions for TRIM58 Gene

SuperPathways for TRIM58 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NG06-TRI58_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM58: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM58 Gene

Drugs & Compounds for TRIM58 Gene

No Compound Related Data Available

Transcripts for TRIM58 Gene

mRNA/cDNA for TRIM58 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM58 Gene

Tripartite motif containing 58:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM58

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM58 Gene

No ASD Table

Relevant External Links for TRIM58 Gene

GeneLoc Exon Structure for
TRIM58
ECgene alternative splicing isoforms for
TRIM58

Expression for TRIM58 Gene

mRNA expression in normal human tissues for TRIM58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM58 Gene

This gene is overexpressed in Whole Blood (x32.7).

Protein differential expression in normal tissues from HIPED for TRIM58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.4), Bone (15.0), and Platelet (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TRIM58 Gene



SOURCE GeneReport for Unigene cluster for TRIM58 Gene Hs.269151

mRNA Expression by UniProt/SwissProt for TRIM58 Gene

Q8NG06-TRI58_HUMAN
Tissue specificity: Expressed in erythroblasts.
genes like me logo Genes that share expression patterns with TRIM58: view

Protein tissue co-expression partners for TRIM58 Gene

Primer Products

In Situ Assay Products

Orthologs for TRIM58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM58 35
  • 84.23 (n)
  • 82.44 (a)
TRIM58 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM58 35
  • 84.71 (n)
  • 81.48 (a)
TRIM58 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim58 35
  • 81.52 (n)
  • 79.92 (a)
Trim58 16
Trim58 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM58 35
  • 98.9 (n)
  • 98.15 (a)
TRIM58 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim58 35
  • 80.4 (n)
  • 80.13 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM58 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM58 36
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770718 35
  • 58.64 (n)
  • 46.17 (a)
-- 36
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 40 (a)
OneToMany
Species with no ortholog for TRIM58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM58 Gene

ENSEMBL:
Gene Tree for TRIM58 (if available)
TreeFam:
Gene Tree for TRIM58 (if available)

Paralogs for TRIM58 Gene

genes like me logo Genes that share paralogs with TRIM58: view

Variants for TRIM58 Gene

Sequence variations from dbSNP and Humsavar for TRIM58 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs946696 -- 247,864,917(-) AGGGC(A/C/T)GGGCG synonymous-codon, reference
rs946703 -- 247,878,923(+) atgac(C/T)cttct utr-variant-3-prime
rs1339847 - 247,875,992(+) GGGAT(A/G)TCCCC missense, reference
rs3737276 -- 247,860,771(-) ATTAC(G/T)GACCC intron-variant
rs3737277 -- 247,860,664(-) AAGGC(A/G)TCCTC reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TRIM58 Gene

Variant ID Type Subtype PubMed ID
esv33129 CNV Gain+Loss 17666407
nsv873440 CNV Gain 21882294
dgv204e1 CNV Complex 17122850
esv34503 CNV Gain 17911159
nsv515858 CNV Gain+Loss 19592680
nsv873442 CNV Gain 21882294
dgv205e1 CNV Complex 17122850
nsv873443 CNV Gain 21882294
nsv827775 CNV Gain 20364138
nsv819723 CNV Gain 19587683
esv1620378 CNV Insertion 17803354
esv2727906 CNV Deletion 23290073
nsv5321 CNV Loss 18451855

Variation tolerance for TRIM58 Gene

Residual Variation Intolerance Score: 39.12% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM58 Gene

HapMap Linkage Disequilibrium report
TRIM58
Human Gene Mutation Database (HGMD)
TRIM58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM58 Gene

Disorders for TRIM58 Gene

Relevant External Links for TRIM58

Genetic Association Database (GAD)
TRIM58
Human Genome Epidemiology (HuGE) Navigator
TRIM58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM58
genes like me logo Genes that share disorders with TRIM58: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM58 Gene

Publications for TRIM58 Gene

  1. Trim58 degrades Dynein and regulates terminal erythropoiesis. (PMID: 25241935) Thom C.S. … Weiss M.J. (Dev. Cell 2014) 67
  2. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 67
  3. New gene functions in megakaryopoiesis and platelet formation. (PMID: 22139419) Gieger C. … Soranzo N. (Nature 2011) 67
  4. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 67
  5. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PMID: 21083371) Chinn L.W. … O'Brien S.J. (J. Infect. Dis. 2010) 67

Products for TRIM58 Gene

Sources for TRIM58 Gene

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