Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM58 Gene

Aliases for TRIM58 Gene

  • Tripartite Motif Containing 58 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM58 3 4
  • Tripartite Motif-Containing Protein 58 3 4
  • E3 Ubiquitin-Protein Ligase TRIM58 3
  • Tripartite Motif-Containing 58 2
  • Protein BIA2 4
  • EC 2.3.2.27 4
  • BIA2 3

External Ids for TRIM58 Gene

Previous GeneCards Identifiers for TRIM58 Gene

  • GC01P244347
  • GC01P246087
  • GC01P248020
  • GC01P218409

Summaries for TRIM58 Gene

GeneCards Summary for TRIM58 Gene

TRIM58 (Tripartite Motif Containing 58) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM21.

UniProtKB/Swiss-Prot for TRIM58 Gene

  • E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM58 Gene

Genomics for TRIM58 Gene

Regulatory Elements for TRIM58 Gene

Enhancers for TRIM58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G247852 0.6 Ensembl 37.9 -4.5 -4499 0.6 MAFF ZNF316 MAFG HMBOX1 NFE2 EMSY MAFK TRIM58 OR2AJ1 OR11L1
GH01G247856 1 ENCODE 21.6 +0.4 447 1.7 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A TCF12 GTF3C2 ZNF766 CBX5 TRIM58 ZNF670-ZNF695 ENSG00000227671 OR2T8 PIR41167
GH01G247854 1.3 FANTOM5 ENCODE 14.8 -1.7 -1692 1.5 HDAC1 TBP ATF1 CBX3 TBL1XR1 CREB3L1 ARNT CHAMP1 TCF12 ZNF766 TRIM58 OR2T8 OR13G1 OR2W3 OR11L1
GH01G247905 1.2 Ensembl ENCODE 10.7 +49.6 49645 1.9 HDAC1 PKNOX1 ZBTB40 TCF12 FOS U2AF2 ZBTB2 CEBPB ELF4 ELF1 OR2AJ1 TRIM58 OR2T8 OR2T12 OR2W3
GH01G247858 0.8 ENCODE 11.1 +1.9 1903 0.5 BCOR HDAC1 PKNOX1 ARNT TAL1 CEBPG ZNF316 FOXK2 NCOR1 ZSCAN29 TRIM58 OR2AJ1 OR2T8 OR2X1P OR2L13 CLK3P2 PIR41167
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM58 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000023236 301 1001 HDGF PKNOX1 ATF1 CREB3L1 ARNT SIN3A TCF12 GTF3C2 ZNF766 CBX5

Genomic Location for TRIM58 Gene

Chromosome:
1
Start:
247,857,199 bp from pter
End:
247,880,138 bp from pter
Size:
22,940 bases
Orientation:
Plus strand

Genomic View for TRIM58 Gene

Genes around TRIM58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM58 Gene

Proteins for TRIM58 Gene

  • Protein details for TRIM58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NG06-TRI58_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM58
    Protein Accession:
    Q8NG06
    Secondary Accessions:
    • Q6B0H9

    Protein attributes for TRIM58 Gene

    Size:
    486 amino acids
    Molecular mass:
    54766 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM63958.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TRIM58 Gene

Post-translational modifications for TRIM58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM58 Gene

Domains & Families for TRIM58 Gene

Gene Families for TRIM58 Gene

Suggested Antigen Peptide Sequences for TRIM58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8NG06

UniProtKB/Swiss-Prot:

TRI58_HUMAN :
  • The RING finger is required for ubiquitin ligase activity.
  • Belongs to the TRIM/RBCC family.
Domain:
  • The RING finger is required for ubiquitin ligase activity.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM58: view

Function for TRIM58 Gene

Molecular function for TRIM58 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
E3 ubiquitin ligase induced during late erythropoiesis. Directly binds and ubiquitinates the intermediate chain of the microtubule motor dynein (DYNC1LI1/DYNC1LI2), stimulating the degradation of the dynein holoprotein complex. May participate in the erythroblast enucleation process through regulation of nuclear polarization.

Enzyme Numbers (IUBMB) for TRIM58 Gene

Gene Ontology (GO) - Molecular Function for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0016740 transferase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM58: view
genes like me logo Genes that share phenotypes with TRIM58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM58 Gene

Localization for TRIM58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM58 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM58 Gene

Pathways & Interactions for TRIM58 Gene

SuperPathways for TRIM58 Gene

No Data Available

UniProtKB/Swiss-Prot Q8NG06-TRI58_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with TRIM58: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM58 Gene

Drugs & Compounds for TRIM58 Gene

No Compound Related Data Available

Transcripts for TRIM58 Gene

mRNA/cDNA for TRIM58 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(40) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM58 Gene

Tripartite motif containing 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM58 Gene

No ASD Table

Relevant External Links for TRIM58 Gene

GeneLoc Exon Structure for
TRIM58
ECgene alternative splicing isoforms for
TRIM58

Expression for TRIM58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TRIM58 Gene

This gene is overexpressed in Whole Blood (x32.7).

Protein differential expression in normal tissues from HIPED for TRIM58 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (31.4), Bone (15.0), and Platelet (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM58 Gene



Protein tissue co-expression partners for TRIM58 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM58 Gene:

TRIM58

SOURCE GeneReport for Unigene cluster for TRIM58 Gene:

Hs.269151

mRNA Expression by UniProt/SwissProt for TRIM58 Gene:

Q8NG06-TRI58_HUMAN
Tissue specificity: Expressed in erythroblasts.

Evidence on tissue expression from TISSUES for TRIM58 Gene

  • Lung(4.4)
genes like me logo Genes that share expression patterns with TRIM58: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM58 Gene

Orthologs for TRIM58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM58 34 35
  • 98.9 (n)
dog
(Canis familiaris)
Mammalia TRIM58 34 35
  • 84.71 (n)
cow
(Bos Taurus)
Mammalia TRIM58 34 35
  • 84.23 (n)
mouse
(Mus musculus)
Mammalia Trim58 34 16 35
  • 81.52 (n)
rat
(Rattus norvegicus)
Mammalia Trim58 34
  • 80.4 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM58 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM58 35
  • 55 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC770718 34
  • 58.64 (n)
-- 35
  • 41 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 40 (a)
OneToMany
Species where no ortholog for TRIM58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM58 Gene

ENSEMBL:
Gene Tree for TRIM58 (if available)
TreeFam:
Gene Tree for TRIM58 (if available)

Paralogs for TRIM58 Gene

Variants for TRIM58 Gene

Sequence variations from dbSNP and Humsavar for TRIM58 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000098897 -- 247,870,282(+) ATTAG(C/G)ATTGG intron-variant
rs1000136606 -- 247,869,355(+) CCTCT(A/G)ATCAC intron-variant
rs1000152842 -- 247,870,449(+) CATGA(A/G)CAGTA intron-variant
rs1000156917 -- 247,857,733(+) GGAGC(C/G)GAGCC intron-variant
rs1000236676 -- 247,858,350(+) CCCAG(A/C)GTGGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM58 Gene

Variant ID Type Subtype PubMed ID
dgv604n100 CNV gain 25217958
dgv605n100 CNV gain 25217958
dgv606n100 CNV gain 25217958
esv1620378 CNV insertion 17803354
esv2727906 CNV deletion 23290073
esv2759014 CNV gain+loss 17122850
esv2762235 CNV gain 21179565
esv33129 CNV gain+loss 17666407
esv34503 CNV gain 17911159
esv3589522 CNV gain 21293372
esv3891415 CNV gain 25118596
nsv1008024 CNV gain 25217958
nsv1010087 CNV gain 25217958
nsv1013273 CNV gain 25217958
nsv515858 CNV gain+loss 19592680
nsv5321 CNV deletion 18451855
nsv549597 CNV gain 21841781
nsv549601 CNV loss 21841781
nsv549602 CNV loss 21841781
nsv819723 CNV gain 19587683
nsv827775 CNV gain 20364138

Variation tolerance for TRIM58 Gene

Residual Variation Intolerance Score: 39.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.88; 79.48% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM58 Gene

Human Gene Mutation Database (HGMD)
TRIM58
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM58 Gene

Disorders for TRIM58 Gene

Relevant External Links for TRIM58

Genetic Association Database (GAD)
TRIM58
Human Genome Epidemiology (HuGE) Navigator
TRIM58
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM58

No disorders were found for TRIM58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM58 Gene

Publications for TRIM58 Gene

  1. Trim58 degrades Dynein and regulates terminal erythropoiesis. (PMID: 25241935) Thom C.S. … Weiss M.J. (Dev. Cell 2014) 3 4 64
  2. Genome-wide association study of hematological and biochemical traits in a Japanese population. (PMID: 20139978) Kamatani Y. … Kamatani N. (Nat. Genet. 2010) 3 46 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Dependence of Human Colorectal Cells Lacking the FBW7 Tumor Suppressor on the Spindle Assembly Checkpoint. (PMID: 26354767) Bailey M.L. … Hieter P. (Genetics 2015) 3 64
  5. Seventy-five genetic loci influencing the human red blood cell. (PMID: 23222517) van der Harst P. … Chambers J.C. (Nature 2012) 3 64

Products for TRIM58 Gene

Sources for TRIM58 Gene

Content
Loading form....