TRIM58 Gene
protein-coding GIFtS: 43
GCID: GC01P248020
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tripartite motif containing 58(Previous name: tripartite motif-containing 58 )
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Aliases
for TRIM58 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 581 2 | | BIA21 2 | | Tripartite Motif-Containing 581 2 | | Tripartite Motif-Containing Protein 582 | | Protein BIA23 |
Export aliases for TRIM58 gene to outside databasesPrevious GC identifers: GC01P244347 GC01P246087 GC01P218409 |
Summaries
for TRIM58 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM58 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_167186.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM58 gene promoter:
GR E2F-4 E2F-3a E2F-5 E2F-2 E47 GATA-2 E2F E2F-1 GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM58
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM58 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44TRIM58 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P248020: view genomic region
(about GC identifiers)
Start:
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248,020,501 bp from pter |
End:
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248,043,440 bp from pter |
Size:
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22,940 bases |
Orientation:
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plus strand |
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Proteins
for TRIM58 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI58_HUMAN, Q8NG06 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 58 Size: 486 amino acids; 54766 Da
Sequence caution: Sequence=AAM63958.1; Type=Erroneous initiation;
Secondary accessions: Q6B0H9Explore the universe of human proteins at neXtProt for TRIM58: NX_Q8NG06
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8NG06
TRIM58 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_056246.3
ENSEMBL proteins: ENSP00000355437
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM58 for ontologies About GeneDecksing
TRIM58 Antibody Products:
Assay Products for TRIM58: |
Protein
Domains /
Families
for TRIM58 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM58 for domains About GeneDecksing
5/10 InterPro domains/families (see all 10):Graphical View of Domain Structure for InterPro Entry Q8NG06ProtoNet protein and cluster: Q8NG06 1 Blocks protein family: IPB003879 Butyrophylin C-terminal DUF signature
UniProtKB/Swiss-Prot: TRI58_HUMAN, Q8NG06Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM58 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM58 (NM_015431) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM58 | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM58 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM58 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM58 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for TRIM58:
|
Pathways & Interactions
for TRIM58 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM58
|
Drugs & Compounds
for TRIM58 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM58
Search CenterWatch for drugs/clinical trials and news about TRIM58 / TRI58
|
Transcripts
for TRIM58 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM58 gene: NM_015431.3 Unigene Cluster for TRIM58: Tripartite motif containing 58 Hs.269151 [show with all ESTs]Unigene Representative Sequence: NM_0154311 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000366481(uc001ido.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM58 (NM_015431) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM58 | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM58 |
Additional cDNA sequence: AF327057.1 AK096188.1 BC074748.2 BC146848.1 BX537432.1 4 DOTS entries: DT.100741838 DT.409988 DT.432546 DT.95099806 24/40 AceView cDNA sequences (see all 40): BX644877 NM_015431 BC074748 CF993737 BX093298 AF327057 N54332 AK096188 BX091434 AI217090 BX537432 W02471 CK002540 NM_001001957 BX509111 BX110624 BV183401 BU659945 N75737 N72691 BQ025714 AA346729 BG026581 AA223483
GeneLoc Exon Structure
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Expression
for TRIM58 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM58 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TRIM58 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM58
SOURCE GeneReport for Unigene cluster: Hs.269151
SABiosciences Custom PCR Arrays for TRIM58
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM58
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM58 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM58 |
Orthologs
for TRIM58 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM58 gene from 3/10 species (see all 10) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
LOC7707181 |
tripartite motif-containing protein 39-like |
58.8(n)
46.33(a) |
|
770718 XM_001232969.2 XP_001232970.2 |
lizard
(Anolis carolinensis) |
Reptilia |
TRIM586 |
-- |
41(a) |
1 → many |
GL343252.1(1250786-1269672) |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
24(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM58 (if available)
TreeFam Gene Tree for TRIM58 (if available) |
Paralogs
for TRIM58 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM58 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM682
- TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM52 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/39 SIMAP similar genes for TRIM58 using alignment to 1 protein entry: TRI58_HUMAN(see all similar genes):TRIM21 TRIM68 BTNL9 TRIM39R TRIM38 DKFZp686F23130
TRIM11 TRIM39 TRIM5 TRIM17 TRIM27 TRIM6
BT3.3 DKFZp781D1977 TRIM31 TRIM34 TRIM4 TRIML1
TRIM58 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM58 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM58 (248020501 - 248043440 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for TRIM58
7 CNVs: 6816 8353 3339 48303 48302 58378 2358 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM58 |
|
Disorders
/ Diseases
for TRIM58 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRIM58 for disorders About MalaCards
TRIM58 for disorders About GeneDecksing
Human Genome Epidemiology (HuGE) Navigator: TRIM58 (1 document)
Export disorders for TRIM58 gene to outside databases
|
Publications
for TRIM58 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM58 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM58) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- New gene functions in megakaryopoiesis and platelet fo rmation. (PubMed id 22139419)1 Gieger C....Soranzo N. (2011)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for TRIM58 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIM58 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM58 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM58 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRIM58 gene:
Search GeneIP for patents involving TRIM58
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM58 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM58 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM58 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM58 | | | OriGene Protein Over-expression Lysate for TRIM58 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM58 | | OriGene 3'-UTR Clone for TRIM58 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM58 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TRIM58 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM58 | | OriGene Custom Protein Services for TRIM58 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM58 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM58 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM58 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM58 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM58 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM58 |
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 |  |  |  | |
| | | | Search Tocris compounds for TRIM58 |
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 | | | TRIM58 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM58 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM58 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TRIM58 |
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