Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM56 Gene

Aliases for TRIM56 Gene

  • Tripartite Motif Containing 56 2 3
  • Tripartite Motif-Containing Protein 56 3 4
  • RING Finger Protein 109 3 4
  • RNF109 3 4
  • E3 Ubiquitin-Protein Ligase TRIM56 3
  • Tripartite Motif-Containing 56 2
  • EC 6.3.2.- 4

External Ids for TRIM56 Gene

Summaries for TRIM56 Gene

GeneCards Summary for TRIM56 Gene

TRIM56 (Tripartite Motif Containing 56) is a Protein Coding gene. Among its related pathways are Cytosolic sensors of pathogen-associated DNA and Cytosolic sensors of pathogen-associated DNA. GO annotations related to this gene include ubiquitin-protein transferase activity. An important paralog of this gene is TRIM71.

UniProtKB/Swiss-Prot for TRIM56 Gene

  • E3 ubiquitin-protein ligase that mediates Lys-63-linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING Lys-63-linked ubiquitination activates the production of type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM56 Gene

Genomics for TRIM56 Gene

Genomic Location for TRIM56 Gene

Start:
101,085,439 bp from pter
End:
101,091,736 bp from pter
Size:
6,298 bases
Orientation:
Plus strand

Genomic View for TRIM56 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM56 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM56 Gene

No data available for Regulatory Elements for TRIM56 Gene

Proteins for TRIM56 Gene

  • Protein details for TRIM56 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BRZ2-TRI56_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM56
    Protein Accession:
    Q9BRZ2
    Secondary Accessions:
    • Q6PJS5
    • Q86VT6
    • Q8N2H8
    • Q8NAC0
    • Q9H031

    Protein attributes for TRIM56 Gene

    Size:
    755 amino acids
    Molecular mass:
    81488 Da
    Quaternary structure:
    • Interacts with TMEM173/STING.
    SequenceCaution:
    • Sequence=AAH11882.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11500.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM56 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM56 Gene

Proteomics data for TRIM56 Gene at MOPED

Post-translational modifications for TRIM56 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys270

Other Protein References for TRIM56 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM56 Gene

Domains for TRIM56 Gene

Gene Families for TRIM56 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

UniProtKB/Swiss-Prot:

TRI56_HUMAN
Family:
  • Belongs to the TRIM/RBCC family.:
    • Q9BRZ2
Similarity:
  • Contains 2 B box-type zinc fingers.:
    • Q9BRZ2
  • Contains 1 RING-type zinc finger.:
    • Q9BRZ2
genes like me logo Genes that share domains with TRIM56: view

Function for TRIM56 Gene

Molecular function for TRIM56 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase that mediates Lys-63-linked polyubiquitination of TMEM173/STING, thereby playing a key role in innate immunity. TMEM173/STING Lys-63-linked ubiquitination activates the production of type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA (By similarity).

Enzyme Numbers (IUBMB) for TRIM56 Gene

Gene Ontology (GO) - Molecular Function for TRIM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity TAS --
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with TRIM56: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM56 Gene

Localization for TRIM56 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM56 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM56 Gene COMPARTMENTS Subcellular localization image for TRIM56 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm ISS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM56: view

Pathways for TRIM56 Gene

genes like me logo Genes that share pathways with TRIM56: view

Pathways by source for TRIM56 Gene

Gene Ontology (GO) - Biological Process for TRIM56 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032479 regulation of type I interferon production TAS --
GO:0032481 positive regulation of type I interferon production TAS --
GO:0032608 interferon-beta production ISS --
GO:0034340 response to type I interferon ISS --
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with TRIM56: view

Transcripts for TRIM56 Gene

Unigene Clusters for TRIM56 Gene

Tripartite motif containing 56:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM56 Gene

No ASD Table

Relevant External Links for TRIM56 Gene

GeneLoc Exon Structure for
TRIM56
ECgene alternative splicing isoforms for
TRIM56

Expression for TRIM56 Gene

mRNA expression in normal human tissues for TRIM56 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TRIM56 Gene

SOURCE GeneReport for Unigene cluster for TRIM56 Gene Hs.521092

genes like me logo Genes that share expressions with TRIM56: view

Orthologs for TRIM56 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM56 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM56 36
  • 98.89 (n)
  • 98.88 (a)
TRIM56 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM56 36
  • 85.3 (n)
  • 87.42 (a)
TRIM56 37
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia -- 37
  • 19 (a)
ManyToMany
TRIM56 36
  • 87.15 (n)
  • 90.86 (a)
mouse
(Mus musculus)
Mammalia Trim56 36
  • 79.22 (n)
  • 83.22 (a)
Trim56 16
Trim56 37
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 19 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia TRIM56 37
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta abba 37
  • 6 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea nhl-1 37
  • 11 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 13 (a)
OneToMany
Species with no ortholog for TRIM56:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • zebrafish (Danio rerio)

Evolution for TRIM56 Gene

ENSEMBL:
Gene Tree for TRIM56 (if available)
TreeFam:
Gene Tree for TRIM56 (if available)

Paralogs for TRIM56 Gene

Paralogs for TRIM56 Gene

Selected SIMAP similar genes for TRIM56 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with TRIM56: view

Variants for TRIM56 Gene

Sequence variations from dbSNP and Humsavar for TRIM56 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs10900 -- 101,090,284(-) GAGAA(C/T)GTGGA utr-variant-3-prime
rs4132583 -- 101,090,046(-) TGTAG(A/G)ACCCT utr-variant-3-prime
rs4524722 -- 101,088,224(+) AGGGC(A/C/G)GCAGC synonymous-codon, reference
rs6945021 -- 101,084,434(+) AACCC(A/G)GGAAG upstream-variant-2KB
rs6968929 -- 101,084,131(+) AATTA(C/T)GGTAA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM56 Gene

Variant ID Type Subtype PubMed ID
esv2734888 CNV Deletion 23290073
dgv2119e1 CNV Complex 17122850
dgv2120e1 CNV Complex 17122850
nsv428181 CNV Gain+Loss 18775914
nsv831074 CNV Loss 17160897
nsv831075 CNV Loss 17160897

Relevant External Links for TRIM56 Gene

HapMap Linkage Disequilibrium report
TRIM56

Disorders for TRIM56 Gene

No disorders were found for TRIM56 Gene.

No data available for UniProtKB/Swiss-Prot for TRIM56 Gene

Publications for TRIM56 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for TRIM56 Gene

Sources for TRIM56 Gene

Back to Top

Content