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TRIM56 Gene

protein-coding   GIFtS: 49
GCID: GC07P100728

Tripartite Motif Containing 56

(Previous name: tripartite motif-containing 56)
  Search for TRIM56
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 561 2     RING Finger Protein 1092 3
Tripartite Motif-Containing 561 2     E3 Ubiquitin-Protein Ligase TRIM562
Tripartite Motif-Containing Protein 562 3     EC 6.3.2.-3
RNF1092 3     

External Ids:    HGNC: 190281   Entrez Gene: 818442   Ensembl: ENSG000001698717   UniProtKB: Q9BRZ23   

Export aliases for TRIM56 gene to outside databases

Previous GC identifers: GC07P099213 GC07P100275 GC07P100288 GC07P100322 GC07P100515 GC07P095322


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIM56 Gene:
TRIM56 (tripartite motif containing 56) is a protein-coding gene. GO annotations related to this gene include ubiquitin-protein ligase activity. An important paralog of this gene is TRIM3.

UniProtKB/Swiss-Prot: TRI56_HUMAN, Q9BRZ2
Function: E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked polyubiquitination of TMEM173/STING, thereby
playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of
type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TRIM56
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TRIM56 promoter sequence
   Search Chromatin IP Primers for TRIM56

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM56


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q22.1   Ensembl cytogenetic band:  7q22.1   HGNC cytogenetic band: 7q11.2

TRIM56 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM56 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P100728:  view genomic region     (about GC identifiers)

Start:
100,728,720 bp from pter      End:
100,735,017 bp from pter
Size:
6,298 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 100,087,175-100,092,298     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TRI56_HUMAN, Q9BRZ2 (See protein sequence)
Recommended Name: E3 ubiquitin-protein ligase TRIM56  
Size: 755 amino acids; 81488 Da
Subunit: Interacts with TMEM173/STING (By similarity)
Sequence caution: Sequence=AAH11882.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC11500.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q6PJS5 Q86VT6 Q8N2H8 Q8NAC0 Q9H031
Alternative splicing: 3 isoforms:  Q9BRZ2-1   Q9BRZ2-2   Q9BRZ2-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM56: NX_Q9BRZ2

Explore proteomics data for TRIM56 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys270
  • Modification sites at PhosphoSitePlus

  • See TRIM56 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_112223.1  
    ENSEMBL proteins: 
     ENSP00000305161   ENSP00000404186  
    Reactome Protein details: Q9BRZ2

    TRIM56 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TRIM56
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM56
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    Novus Biologicals TRIM56 Protein
    Novus Biologicals TRIM56 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM56

    TRIM56 Antibody Products:

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    Abcam antibodies for TRIM56
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    ThermoFisher Antibodies for TRIM56
    LSBio Antibodies in human, mouse, rat for TRIM56

    TRIM56 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for TRIM56
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    Cloud-Clone Corp. ELISAs for TRIM56
    Cloud-Clone Corp. CLIAs for TRIM56


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 6):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR011042 6-blade_b-propeller_TolB-like
     IPR000315 Znf_B-box
     IPR018957 Znf_C3HC4_RING-type

    Graphical View of Domain Structure for InterPro Entry Q9BRZ2

    ProtoNet protein and cluster: Q9BRZ2

    3 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI56_HUMAN, Q9BRZ2
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 RING-type zinc finger


    TRIM56 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI56_HUMAN, Q9BRZ2
    Function: E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked polyubiquitination of TMEM173/STING, thereby
    playing a key role in innate immunity. TMEM173/STING 'Lys-63'-linked ubiquitination activates the production of
    type I interferon IFN-beta following detection of pathogen- and host-derived double-stranded DNA (By similarity)

         Enzyme Number (IUBMB): EC 6.3.2.-1

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004842ubiquitin-protein ligase activity TAS--
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0044822poly(A) RNA binding IDA--
    GO:0046872metal ion binding ----
         
    TRIM56 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM56
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM56

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM56
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM56

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TRIM56 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TRIM56:
    hsa-miR-2052 hsa-miR-133a hsa-miR-3185 hsa-miR-1271 hsa-miR-133b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidTRIM56 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM56
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM56

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM56

    Clone
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    OriGene clones in human, mouse for TRIM56 (see all 6)
    OriGene ORF clones in mouse, rat for TRIM56
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM56 (NM_030961)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM56
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM56

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM56 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM56


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI56_HUMAN, Q9BRZ2: Cytoplasm (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm ISS--
    GO:0005829cytosol TAS--

    TRIM56 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TRIM56 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    Cytosolic sensors of pathogen-associated DNA0.38
    Regulation of innate immune responses to cytosolic DNA0.00

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for TRIM56
        Regulation of innate immune responses to cytosolic DNA



    TRIM56 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM56: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM56

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for TRIM56 (Q9BRZ23 ENSP000003051614) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TMEM173Q86WV63, ENSP000003312884I2D: score=1 STRING: ENSP00000331288
    UBE2HP622563, ENSP000003478364I2D: score=2 STRING: ENSP00000347836
    APCP250543I2D: score=2 
    CNBPP626333I2D: score=1 
    --ENSP000003038444STRING: ENSP00000303844
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0032479regulation of type I interferon production TAS--
    GO:0032481positive regulation of type I interferon production TAS--
    GO:0032608interferon-beta production ISS--
    GO:0034340response to type I interferon ISS--
    GO:0045087innate immune response TAS--

    TRIM56 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM56 (TRI56)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM56 gene: 
    NM_030961.1  

    Unigene Cluster for TRIM56:

    Tripartite motif containing 56
    Hs.521092  [show with all ESTs]
    Unigene Representative Sequence: BC005847
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000306085(uc003uxq.3) ENST00000412507(uc003uxr.3) ENST00000467847
    ENST00000487252
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM56 using miScript Target Protectors
    6 qRT-PCR Assays for microRNAs that regulate TRIM56:
    hsa-miR-2052 hsa-miR-133a hsa-miR-3185 hsa-miR-1271 hsa-miR-133b hsa-miR-96
    SwitchGear 3'UTR luciferase reporter plasmidTRIM56 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM56
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM56
    Clone
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    OriGene clones in human, mouse for TRIM56 (see all 6)
    OriGene ORF clones in mouse, rat for TRIM56
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM56 (NM_030961)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM56
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM56
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM56
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM56
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat TRIM56
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM56
      QuantiFast Probe-based Assays in human, mouse, rat TRIM56

    Additional mRNA sequence: 

    AK075255.1 AL512757.1 BC005847.2 BC011882.2 BC048194.1 BC128050.1 

    6 DOTS entries:

    DT.435379  DT.97806615  DT.100031169  DT.95300058  DT.100752520  DT.121117792 

    Selected AceView cDNA sequences (see all 145):

    BU687184 BQ223903 BM272584 BM313880 BC011882 BQ049558 BM894020 AW328506 
    AI031714 BE301033 BE302899 BG943871 NM_030961 BE301071 BG574808 BC048194 
    BI467347 CA443882 BQ929018 BE876112 AI089989 AI474342 BM352587 BU688360 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM56 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTCCCACG
    TRIM56 Expression
    About this image


    TRIM56 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Testis (Reproductive System)
             Sertoli cells Seminiferous Tubules
    TRIM56 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM56 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.521092
        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM56: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM56
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    QuantiFast Probe-based Assays in human, mouse, rat TRIM56
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM56

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM56 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim561 , 5 tripartite motif-containing 561, 5 79.22(n)1
    83.22(a)1
      5 (76.19 cM)5
    3843091  NM_201373.41  NP_958761.11 
     1371056445 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM566
    tripartite motif containing 56
    47(a)
    1 ↔ 1
    GL344173.1(55697-58061)
    fruit fly
    (Drosophila melanogaster)
    Insecta abba6
    another B-box affiliate
    6(a)
    many ↔ many
    2R(14874846-14896469)
    worm
    (Caenorhabditis elegans)
    Secernentea nhl-16
    Protein NHL-1 (nhl-1) mRNA, complete cds
    11(a)
    many ↔ many
    III(9147389-9153890) WBGene00003597


    ENSEMBL Gene Tree for TRIM56 (if available)
    TreeFam Gene Tree for TRIM56 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM56 gene
    TRIM32  TRIM712  TRIM452  TRIM22  
    2 SIMAP similar genes for TRIM56 using alignment to 2 protein entries:     TRI56_HUMAN (see all proteins):
    TRIM39    TRIM5

    TRIM56 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM56 (see all 214)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1872951671,2
    --104092318(+) TAGCTG/TGGACT 1 -- us2k10--------
    rs734048711,2
    C,F--104092494(+) GGTTTT/GGTTTT 1 -- us2k15Minor allele frequency- G:0.26WA CSA NA 243
    rs78014281,2
    C,F--104092625(+) GGCCTA/GTTTTT 1 -- us2k111Minor allele frequency- G:0.16NA WA CSA EA 372
    rs1132692401,2
    C,F--104092687(+) CCCCTC/TGTCCT 1 -- us2k12Minor allele frequency- T:0.05CSA WA 120
    rs1154162221,2
    F--104092742(+) TCTTTT/CGGATT 1 -- us2k11Minor allele frequency- C:0.02WA 118
    rs69689291,2
    C,F,A,H--104092932(+) AATTAT/CGGTAA 1 -- us2k128Minor allele frequency- C:0.27NS EA NA WA CSA 2763
    rs1904353961,2
    --104093047(+) GCTCAC/TGCCTG 1 -- us2k10--------
    rs1136442141,2
    C--104093129(+) ACATAG/ATGAAA 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs69450211,2
    C,F--104093235(+) AACCCA/GGGAAG 1 -- us2k15Minor allele frequency- G:0.30NA WA CSA 10
    rs1389453451,2
    C--104093241(+) GGAAGC/TGGAGG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM56 (100728720 - 100735017 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for TRIM56:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2734888CNV Deletion23290073
    nsv831075CNV Loss17160897
    nsv831074CNV Loss17160897
    nsv428181CNV Gain+Loss18775914
    dgv2119e1CNV Complex17122850
    dgv2120e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM56
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM56

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM56 gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with TRIM56)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    5. The proteomic analysis of endogenous FAT10 substrates identifies p62/SQSTM1 as a substrate of FAT10ylation. (PubMed id 22797925)1 Aichem A....Groettrup M. (J. Cell. Sci. 2012)
    6. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    7. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PubMed id 22939624)1 Taipale M....Lindquist S. (Cell 2012)
    8. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    9. TRIM56 is an essential component of the TLR3 antiviral signaling pathway. (PubMed id 22948160)1 Shen Y....Li K. (J. Biol. Chem. 2012)
    10. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81844 HGNC: 19028 AceView: TRIM56 Ensembl:ENSG00000169871 euGenes: HUgn81844
    ECgene: TRIM56 H-InvDB: TRIM56

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM56 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM56 gene:
    Search GeneIP for patents involving TRIM56

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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