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Aliases for TRIM55 Gene

Aliases for TRIM55 Gene

  • Tripartite Motif Containing 55 2 3 5
  • Muscle-Specific RING Finger Protein 2 3 4
  • Ring Finger Protein 29 2 3
  • MURF-2 3 4
  • MuRF2 3 4
  • RNF29 3 4
  • Tripartite Motif-Containing Protein 55 3
  • Tripartite Motif-Containing 55 2
  • Muscle Specific Ring Finger 2 3
  • RING Finger Protein 29 4

External Ids for TRIM55 Gene

Previous HGNC Symbols for TRIM55 Gene

  • RNF29

Previous GeneCards Identifiers for TRIM55 Gene

  • GC08P067202
  • GC08P067039
  • GC08P062529
  • GC08P066126
  • GC08P066123
  • GC08P066130
  • GC08P066134
  • GC08P066138
  • GC08P066143

Summaries for TRIM55 Gene

Entrez Gene Summary for TRIM55 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM55 Gene

TRIM55 (Tripartite Motif Containing 55) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is TRIM54.

UniProtKB/Swiss-Prot for TRIM55 Gene

  • May regulate gene expression and protein turnover in muscle cells.

Gene Wiki entry for TRIM55 Gene

Additional gene information for TRIM55 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM55 Gene

Genomics for TRIM55 Gene

Regulatory Elements for TRIM55 Gene

Enhancers for TRIM55 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH08H066157 0.8 ENCODE dbSUPER 11.4 +45.4 45363 4.2 PKNOX1 ZSCAN4 FOXP2 RUNX3 CRH TRIM55 LINC00967 GC08P066170 PIR59286 GC08P066139 GC08P066144
GH08H066165 0.7 ENCODE dbSUPER 11.5 +54.9 54862 3.7 POLR2A MNT FOXP2 LINC00967 TRIM55 ADHFE1 RRS1 RRS1-AS1 GC08P066170 PIR59286 GC08P066139 GC08P066144
GH08H066151 0.6 dbSUPER 11.3 +39.8 39770 1.1 ZNF555 SCRT2 ZFP64 ZC3H11A ZNF623 ZNF781 ZNF518A ZNF697 CSPP1 CRH TRIM55 C8orf44 ARMC1 LINC00967 GC08P066170 GC08P066139 PIR59286 GC08P066144
GH08H066171 0.5 dbSUPER 11.5 +60.1 60070 2.4 ZNF629 CREB1 ATF7 ATF2 ZBTB20 TRIM55 ADHFE1 RRS1 RRS1-AS1 LINC00967 GC08P066170 CRH
GH08H066155 0.5 ENCODE dbSUPER 11.2 +42.9 42948 0.1 CRH TRIM55 GC08P066170 GC08P066139 GC08P066144 PIR59286
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM55 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM55 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TRIM55 Gene

Genomic Locations for TRIM55 Gene
62,823 bases
Plus strand

Genomic View for TRIM55 Gene

Genes around TRIM55 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM55 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM55 Gene

Proteins for TRIM55 Gene

  • Protein details for TRIM55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 55
    Protein Accession:
    Secondary Accessions:
    • B3KRC0
    • B3KRJ3
    • Q53XX3
    • Q8IUD9
    • Q8IUE4
    • Q96DV2
    • Q96DV3
    • Q9BYV5

    Protein attributes for TRIM55 Gene

    548 amino acids
    Molecular mass:
    60466 Da
    Quaternary structure:
    • Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
    • Sequence=AAP35876.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32839.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32840.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM55 Gene


neXtProt entry for TRIM55 Gene

Post-translational modifications for TRIM55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM55 Gene

Domains & Families for TRIM55 Gene

Gene Families for TRIM55 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Suggested Antigen Peptide Sequences for TRIM55 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TRIM55: view

No data available for UniProtKB/Swiss-Prot for TRIM55 Gene

Function for TRIM55 Gene

Molecular function for TRIM55 Gene

UniProtKB/Swiss-Prot Function:
May regulate gene expression and protein turnover in muscle cells.

Gene Ontology (GO) - Molecular Function for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding IPI 25127057
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM55: view
genes like me logo Genes that share phenotypes with TRIM55: view

Animal Models for TRIM55 Gene

MGI Knock Outs for TRIM55:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM55 Gene

Localization for TRIM55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM55 Gene

Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM55 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 2
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule NAS 11243782
genes like me logo Genes that share ontologies with TRIM55: view

Pathways & Interactions for TRIM55 Gene

SuperPathways for TRIM55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 11243782
genes like me logo Genes that share ontologies with TRIM55: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM55 Gene

Drugs & Compounds for TRIM55 Gene

No Compound Related Data Available

Transcripts for TRIM55 Gene

Unigene Clusters for TRIM55 Gene

Tripartite motif containing 55:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM55 Gene

No ASD Table

Relevant External Links for TRIM55 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM55 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM55 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM55 Gene

This gene is overexpressed in Heart - Atrial Appendage (x16.5), Heart - Left Ventricle (x15.9), Muscle - Skeletal (x8.0), and Liver (x5.7).

Protein differential expression in normal tissues from HIPED for TRIM55 Gene

This gene is overexpressed in Fetal heart (55.5) and Heart (13.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM55 Gene

Protein tissue co-expression partners for TRIM55 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM55 Gene:


SOURCE GeneReport for Unigene cluster for TRIM55 Gene:


mRNA Expression by UniProt/SwissProt for TRIM55 Gene:

Tissue specificity: Highly expressed in muscle. Low-level expression in liver.

Evidence on tissue expression from TISSUES for TRIM55 Gene

  • Muscle(4.5)
  • Heart(4.4)
genes like me logo Genes that share expression patterns with TRIM55: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM55 Gene

Orthologs for TRIM55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM55 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM55 33 34
  • 99.51 (n)
(Canis familiaris)
Mammalia TRIM55 33 34
  • 91.18 (n)
(Bos Taurus)
Mammalia TRIM55 33 34
  • 87.97 (n)
(Mus musculus)
Mammalia Trim55 33 16 34
  • 85.33 (n)
(Rattus norvegicus)
Mammalia Trim55 33
  • 85.08 (n)
(Monodelphis domestica)
Mammalia TRIM55 34
  • 79 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM55 34
  • 76 (a)
(Gallus gallus)
Aves TRIM55 33 34
  • 80.49 (n)
(Anolis carolinensis)
Reptilia TRIM55 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim55 33
  • 68.57 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.15918 33
(Danio rerio)
Actinopterygii trim55b 33 34
  • 70.31 (n)
trim55a 34
  • 54 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 53 (a)
Species where no ortholog for TRIM55 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM55 Gene

Gene Tree for TRIM55 (if available)
Gene Tree for TRIM55 (if available)

Paralogs for TRIM55 Gene

(2) SIMAP similar genes for TRIM55 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM55: view

Variants for TRIM55 Gene

Sequence variations from dbSNP and Humsavar for TRIM55 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type
rs1000042992 -- 66,151,511(+) AAAAA(A/G)ATCGC intron-variant
rs1000274361 -- 66,132,943(+) TTTGC(A/G)TATAC intron-variant
rs1000275819 -- 66,134,107(+) CTAAA(C/T)TGATT intron-variant
rs1000326838 -- 66,122,368(+) CTTCC(C/T)GCCTT intron-variant
rs1000383049 -- 66,140,105(+) AAGTG(A/G)GCAGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM55 Gene

Variant ID Type Subtype PubMed ID
nsv474694 CNV novel sequence insertion 20440878
esv3617479 CNV loss 21293372
esv2660962 CNV deletion 23128226

Variation tolerance for TRIM55 Gene

Residual Variation Intolerance Score: 38.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.91; 35.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM55 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM55 Gene

Disorders for TRIM55 Gene

Relevant External Links for TRIM55

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM55 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM55 Gene

Publications for TRIM55 Gene

  1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T … Labeit S (Journal of molecular biology 2001) 2 3 4 60
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 60
  3. The kinase domain of titin controls muscle gene expression and protein turnover. (PMID: 15802564) Lange S … Gautel M (Science (New York, N.Y.) 2005) 3 4 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60

Products for TRIM55 Gene

Sources for TRIM55 Gene

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