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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TRIM55 Gene

protein-coding   GIFtS: 50
GCID: GC08P067039

tripartite motif containing 55

(Previous names: ring finger protein 29, tripartite motif-containing 55...)
(Previous symbol: RNF29)
  Search for TRIM55
in our new
 Human Malady Compendium 
Biological research products
for TRIM55
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
Tripartite Motif Containing 551 2     MuRF23
RING Finger Protein 291 2 3     Muscle Specific Ring Finger 22
RNF291 2 3     Tripartite Motif-Containing Protein 552
MURF-21 2     MURF23
Tripartite Motif-Containing 551 2     MuRF-23
Muscle-Specific RING Finger Protein 22 3     MuRF23

External Ids:    HGNC: 142151   Entrez Gene: 846752   Ensembl: ENSG000001475737   OMIM: 6064695   UniProtKB: Q9BYV63   

Export aliases for TRIM55 gene to outside databases

Previous GC identifers: GC08P067202 GC08P062529


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TRIM55:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein
interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere
assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four
alternatively spliced transcript variants encoding distinct isoforms have been described. (provided by RefSeq, Jul
2008)

UniProtKB/Swiss-Prot: TRI55_HUMAN, Q9BYV6
Function: May regulate gene expression and protein turnover in muscle cells (By similarity)

Gene Wiki entry for TRIM55


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000008.10  NC_018919.1  NT_008183.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TRIM55 gene promoter:
         c-Fos   USF1   AML1a   FOXF2   AP-1   HTF   CUTL1   AREB6   Egr-2   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM55 promoter sequence
   Search SABiosciences Chromatin IP Primers for TRIM55

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM55


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8q13.1   Ensembl cytogenetic band:  8q13.1   HGNC cytogenetic band: 8q13.1

TRIM55 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM55 gene location

GeneLoc information about chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P067039:  view genomic region     (about GC identifiers)

Start:
67,039,131 bp from pter      End:
67,087,720 bp from pter
Size:
48,590 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: TRI55_HUMAN, Q9BYV6 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 55  
Size: 548 amino acids; 60466 Da
Subunit: Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with
SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with
TRIM63 and TRIM54
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Nuclear under atrophic conditions and
upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules
(By similarity)
Caution: It is uncertain whether Met-1 or Met-17 is the initiator
Sequence caution: Sequence=AAP35876.1; Type=Erroneous initiation; Sequence=CAC32839.1; Type=Erroneous initiation;
Sequence=CAC32840.1; Type=Erroneous initiation;
Secondary accessions: B3KRC0 B3KRJ3 Q53XX3 Q8IUD9 Q8IUE4 Q96DV2 Q96DV3 Q9BYV5
Alternative splicing: 4 isoforms:  Q9BYV6-1   Q9BYV6-2   Q9BYV6-3   Q9BYV6-4   

Explore the universe of human proteins at neXtProt for TRIM55: NX_Q9BYV6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9BYV6

  • TRIM55 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (4 alternative transcripts): 
    NP_149047.2  NP_908973.1  NP_908974.1  NP_908975.1  

    ENSEMBL proteins: 
     ENSP00000323913   ENSP00000297348   ENSP00000276573   ENSP00000332302  

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    Uscn Proteins for TRIM55

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005874microtubule NAS11243782


    TRIM55 for ontologies           About GeneDecksing



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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TRIM55 for domains           About GeneDecksing

    5 InterPro domains/families:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR017903 COS_domain
     IPR000315 Znf_B-box
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9BYV6

    ProtoNet protein and cluster: Q9BYV6

    2 Blocks protein families:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI55_HUMAN, Q9BYV6
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 RING-type zinc finger


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section

    Function Summary:

         UniProtKB/Swiss-Prot: TRI55_HUMAN, Q9BYV6
    Function: May regulate gene expression and protein turnover in muscle cells (By similarity)

    miRNA
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    hsa-miR-9 hsa-miR-3673 hsa-miR-133a hsa-miR-133b
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    Inhib. RNA
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    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS11243782
    GO:0008270zinc ion binding IEA--
    GO:0042802identical protein binding IPI--


    TRIM55 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for TRIM55:
     Decreased p24 protein expressi  Increased cell death HMECs cel 

    Animal Models:
         Mouse knock-out Trim55tm1Slbt for TRIM55
         8 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Trim55):
     adipose tissue  cardiovascular system  growth/size  homeostasis/metabolism  liver/biliary system 
     mortality/aging  muscle  respiratory system 

    TRIM55 for phenotypes           About GeneDecksing


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM55

    STRING Interaction Network Preview (showing 5 interactants - click image to see 19)

    5/21 Interacting proteins for TRIM55 (Q9BYV61, 2, 3 ENSP000003239134) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GFM1Q96RP92, 3, ENSP000004190384MINT-6492275 I2D: score=1 STRING: ENSP00000419038
    EEF1GP266412, 3MINT-6492286 I2D: score=1 
    CCAR1Q8IX122, 3, ENSP000002658724MINT-6492264 I2D: score=1 STRING: ENSP00000265872
    TRIM63Q969Q13, ENSP000003633904I2D: score=2 STRING: ENSP00000363390
    UBE2D2P628373, ENSP000003817174I2D: score=2 STRING: ENSP00000381717
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165signal transduction NAS11243782


    TRIM55 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TRIM55
    Search CenterWatch for drugs/clinical trials and news about TRIM55 / TRI55 

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TRIM55 gene (4 alternative transcripts): 
    NM_033058.2  NM_184085.1  NM_184086.1  NM_184087.1  

    Unigene Cluster for TRIM55:

    Tripartite motif containing 55
    Hs.85524  [show with all ESTs]
    Unigene Representative Sequence: NM_033058
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000315962(uc003xvu.3 uc003xvv.3) ENST00000353317(uc003xvw.3 uc003xvx.3)
    ENST00000276573 ENST00000350034 ENST00000517647

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    Inhib. RNA
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    Additional cDNA sequence: 

    AJ243488.1 AJ243489.1 AJ277493.1 AJ291712.1 AJ431704.1 AK091310.1 AK091728.1 BC007750.2 
    BT007212.1 

    7 DOTS entries:

    DT.40227561  DT.106551  DT.101982784  DT.95267856  DT.91703258  DT.100751677  DT.40292865 

    24/69 AceView cDNA sequences (see all 69):

    AJ243489 AI655180 AK091310 AA443443 AJ572152 BQ013623 AJ277493 BC007750 
    AI634359 BG674823 AX747148 AA443309 BX100765 AK091728 BQ013358 BX116127 
    NM_184087 AI917684 AJ291712 AJ431704 NM_184086 AI457692 NM_184085 NM_033058 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TRIM55 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGTTTAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)

    About this image

    TRIM55 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    Stem Cell Differentiation: 4 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor SK17 (Embryonic Progenitor Cell)
    PureStem™ progenitor W10 (Embryonic Progenitor Cell)
    Syncytiotrophoblast-like cells (Generation of syncyt...)
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TRIM55 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TRIM55

    SOURCE GeneReport for Unigene cluster: Hs.85524

    UniProtKB/Swiss-Prot: TRI55_HUMAN, Q9BYV6
    Tissue specificity: Highly expressed in muscle. Low-level expression in liver

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM55 gene from 4/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves TRIM551 tripartite motif containing 55 75.46(n)
    79.86(a)
      420166  NM_001199404.1  NP_001186333.1 
    lizard
    (Anolis carolinensis)
    Reptilia TRIM556
    --
    64(a)
    1 ↔ 1
    4(30684163-30704921)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.159182 Xenopus laevis transcribed sequence with moderate similarity more 79.29(n)    BJ033623.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim55b1 tripartite motif-containing 55b 70.28(n)
    70.48(a)
      664753  NM_001039982.1  NP_001035071.1 


    ENSEMBL Gene Tree for TRIM55 (if available)
    TreeFam Gene Tree for TRIM55 (if available) 

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TRIM55 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM672  TRIM92  TRIM362  
    MID12  MID22  TRIM542  FSD12  
    2 SIMAP similar genes for TRIM55 using alignment to 1 protein entry:     TRI55_HUMAN:
    TRIM54    TRIM63

    TRIM55 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/848 NCBI SNPs in TRIM55 are shown (see all 848    About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 8 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1815293091,2
    --67037389(+) CCTTCA/GAAATC 4 -- us2k10--------
    rs736939111,2
    C,--67037427(+) TCCTGG/ACACGC 4 -- us2k11Minor allele frequency- A:0.50WA 2
    rs754202041,2
    --67037463(+) TTCTCG/AATTGA 4 -- us2k13Minor allele frequency- A:0.18CSA WA NA 240
    rs760967241,2
    F,--67037552(+) TCTCCA/CCTCTT 4 -- us2k11Minor allele frequency- C:0.02WA 118
    rs1166981721,2
    F,--67037615(+) CAGAGC/ACTCAC 4 -- us2k11Minor allele frequency- A:0.05WA 118
    rs584571271,2
    F,--67037621(+) CTCACA/GCAATG 4 -- us2k11Minor allele frequency- G:0.18WA 118
    rs779871331,2
    --67037886(+) TTACCA/TGTTCC 4 -- us2k10--------
    rs1866604731,2
    --67037900(+) CCTCCC/TTGTAG 4 -- us2k10--------
    rs64722511,2
    C,F,A,H,--67037934(+) CTAAGA/GTAATT 4 -- us2k1 tfbs323Minor allele frequency- G:0.31NA NS EA WA CSA 2281
    rs1482712961,2
    --67037950(+) AAGATC/TCCTGA 4 -- us2k10--------

    HapMap Linkage Disequilibrium report for TRIM55 (67039131 - 67087720 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TRIM55: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM55
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM55

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TRIM55 for disorders           About MalaCards

    TRIM55 for disorders           About GeneDecksing

    OMIM gene information: 606469    OMIM disorders: --

    Human Genome Epidemiology (HuGE) Navigator: TRIM55 (2 documents)

    Export disorders for TRIM55 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TRIM55 gene, integrated from 9 sources (see all 15):
    (articles sorted by number of sources associating them with TRIM55)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PubMed id 11243782)1, 2, 3 Centner T....Labeit S. (2001)
    2. The kinase domain of titin controls muscle gene expression and protein turnover. (PubMed id 15802564)1, 2 Lange S.... Gautel M. (2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. (PubMed id 12414993)1, 2 Pizon V.... Gautel M. (2002)
    6. Genome-wide study of gene variants associated with dif ferential cardiovascular event reduction by pravastatin therapy. (PubMed id 22666496)1 Shiffman D....Jukema J.W. (2012)
    7. Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
    8. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    9. A microarray of ubiquitylated proteins for profiling d eubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (2012)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84675 HGNC: 14215 AceView: RNF29 Ensembl:ENSG00000147573 euGenes: HUgn84675
    ECgene: TRIM55 H-InvDB: TRIM55

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TRIM55 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for TRIM55 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TRIM55 gene:
    Search GeneIP for patents involving TRIM55

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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