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Aliases for TRIM55 Gene

Aliases for TRIM55 Gene

  • Tripartite Motif Containing 55 2 3
  • MURF2 3 4 6
  • RNF29 3 4 6
  • Muscle-Specific RING Finger Protein 2 3 4
  • Tripartite Motif-Containing 55 2 3
  • Ring Finger Protein 29 2 3
  • MURF-2 3 4
  • Tripartite Motif-Containing Protein 55 3
  • Muscle Specific Ring Finger 2 3
  • RING Finger Protein 29 4

External Ids for TRIM55 Gene

Previous Symbols for TRIM55 Gene

  • RNF29

Summaries for TRIM55 Gene

Entrez Gene Summary for TRIM55 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM55 Gene

TRIM55 (Tripartite Motif Containing 55) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and signal transducer activity. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM55 Gene

  • May regulate gene expression and protein turnover in muscle cells.

Gene Wiki entry for TRIM55 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM55 Gene

Genomics for TRIM55 Gene

Genomic Location for TRIM55 Gene

Start:
66,126,896 bp from pter
End:
66,175,487 bp from pter
Size:
48,592 bases
Orientation:
Plus strand

Genomic View for TRIM55 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM55 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM55 Gene

Regulatory Elements for TRIM55 Gene

Proteins for TRIM55 Gene

  • Protein details for TRIM55 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV6-TRI55_HUMAN
    Recommended name:
    Tripartite motif-containing protein 55
    Protein Accession:
    Q9BYV6
    Secondary Accessions:
    • B3KRC0
    • B3KRJ3
    • Q53XX3
    • Q8IUD9
    • Q8IUE4
    • Q96DV2
    • Q96DV3
    • Q9BYV5

    Protein attributes for TRIM55 Gene

    Size:
    548 amino acids
    Molecular mass:
    60466 Da
    Quaternary structure:
    • Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.
    SequenceCaution:
    • Sequence=AAP35876.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32839.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32840.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM55 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM55 Gene

Proteomics data for TRIM55 Gene at MOPED

Post-translational modifications for TRIM55 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM55 Gene

No data available for DME Specific Peptides for TRIM55 Gene

Domains for TRIM55 Gene

Gene Families for TRIM55 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM55 Gene

UniProtKB/Swiss-Prot:

TRI55_HUMAN
Domain:
  • Contains 1 COS domain.:
    • Q9BYV6
Similarity:
  • Contains 1 B box-type zinc finger.:
    • Q9BYV6
  • Contains 1 RING-type zinc finger.:
    • Q9BYV6
genes like me logo Genes that share domains with TRIM55: view

Function for TRIM55 Gene

Molecular function for TRIM55 Gene

UniProtKB/Swiss-Prot Function: May regulate gene expression and protein turnover in muscle cells.

Gene Ontology (GO) - Molecular Function for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0042802 identical protein binding IPI 22493164
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM55: view
genes like me logo Genes that share phenotypes with TRIM55: view

Animal Models for TRIM55 Gene

MGI Knock Outs for TRIM55:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM55 Gene

Localization for TRIM55 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM55 Gene

Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM55 Gene COMPARTMENTS Subcellular localization image for TRIM55 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005874 microtubule NAS 11243782
genes like me logo Genes that share ontologies with TRIM55: view

Pathways for TRIM55 Gene

SuperPathways for TRIM55 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM55 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction NAS 11243782
genes like me logo Genes that share ontologies with TRIM55: view

No data available for Pathways by source for TRIM55 Gene

Transcripts for TRIM55 Gene

Unigene Clusters for TRIM55 Gene

Tripartite motif containing 55:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM55 Gene

No ASD Table

Relevant External Links for TRIM55 Gene

GeneLoc Exon Structure for
TRIM55
ECgene alternative splicing isoforms for
TRIM55

Expression for TRIM55 Gene

mRNA expression in normal human tissues for TRIM55 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM55 Gene

This gene is overexpressed in Heart - Atrial Appendage (16.5), Heart - Left Ventricle (15.9), Muscle - Skeletal (8.0), and Liver (5.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TRIM55 Gene

SOURCE GeneReport for Unigene cluster for TRIM55 Gene Hs.85524

mRNA Expression by UniProt/SwissProt for TRIM55 Gene

Q9BYV6-TRI55_HUMAN
Tissue specificity: Highly expressed in muscle. Low-level expression in liver.
genes like me logo Genes that share expressions with TRIM55: view

Orthologs for TRIM55 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM55 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM55 36
  • 99.51 (n)
  • 99.45 (a)
TRIM55 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM55 36
  • 87.97 (n)
  • 87.29 (a)
TRIM55 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM55 36
  • 91.18 (n)
  • 91.61 (a)
TRIM55 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim55 36
  • 85.33 (n)
  • 84.71 (a)
Trim55 16
Trim55 37
  • 85 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM55 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM55 37
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim55 36
  • 85.08 (n)
  • 83.98 (a)
chicken
(Gallus gallus)
Aves TRIM55 36
  • 80.49 (n)
  • 89.02 (a)
TRIM55 37
  • 77 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TRIM55 37
  • 68 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.15918 36
tropical clawed frog
(Silurana tropicalis)
Amphibia trim55 36
  • 68.57 (n)
  • 65.02 (a)
zebrafish
(Danio rerio)
Actinopterygii trim55a 37
  • 54 (a)
OneToMany
trim55b 36
  • 70.31 (n)
  • 71.7 (a)
trim55b 37
  • 63 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 53 (a)
OneToMany
Species with no ortholog for TRIM55:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM55 Gene

ENSEMBL:
Gene Tree for TRIM55 (if available)
TreeFam:
Gene Tree for TRIM55 (if available)

Paralogs for TRIM55 Gene

Selected SIMAP similar genes for TRIM55 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM55: view

Variants for TRIM55 Gene

Sequence variations from dbSNP and Humsavar for TRIM55 Gene

SNP ID Clin Chr 08 pos Sequence Context AA Info Type MAF
rs1054108 -- 66,174,731(+) AACTG(C/T)AATTC utr-variant-3-prime
rs2357669 -- 66,127,704(+) gtggc(C/G)ggcac intron-variant
rs2357670 -- 66,137,384(+) TGAGG(C/G)AGATG intron-variant
rs2446433 -- 66,155,896(-) CTCAG(A/G)AAGAG intron-variant
rs2469280 -- 66,131,265(+) ACTTT(A/T)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM55 Gene

Variant ID Type Subtype PubMed ID
esv2660962 CNV Deletion 23128226

Relevant External Links for TRIM55 Gene

HapMap Linkage Disequilibrium report
TRIM55
Human Gene Mutation Database (HGMD)
TRIM55

Disorders for TRIM55 Gene

Relevant External Links for TRIM55

Genetic Association Database (GAD)
TRIM55
Human Genome Epidemiology (HuGE) Navigator
TRIM55
genes like me logo Genes that share disorders with TRIM55: view

No data available for UniProtKB/Swiss-Prot for TRIM55 Gene

Publications for TRIM55 Gene

  1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 3 4
  2. Transient association of titin and myosin with microtubules in nascent myofibrils directed by the MURF2 RING-finger protein. (PMID: 12414993) Pizon V. … Gautel M. (J. Cell Sci. 2002) 3 4
  3. The kinase domain of titin controls muscle gene expression and protein turnover. (PMID: 15802564) Lange S. … Gautel M. (Science 2005) 3 4
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4

Products for TRIM55 Gene

Sources for TRIM55 Gene

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