Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM54 Gene

Aliases for TRIM54 Gene

  • Tripartite Motif Containing 54 2 3
  • Muscle-Specific RING Finger Protein 3 3 4
  • Tripartite Motif-Containing 54 2 3
  • Ring Finger Protein 30 2 3
  • MURF-3 3 4
  • MuRF3 3 4
  • RNF30 3 4
  • MURF 3 4
  • Muscle-Specific RING-Finger Protein 3 3
  • Muscle-Specific RING Finger Protein 4
  • RING Finger Protein 30 4

External Ids for TRIM54 Gene

Previous HGNC Symbols for TRIM54 Gene

  • RNF30

Previous GeneCards Identifiers for TRIM54 Gene

  • GC02P027418
  • GC02P027506

Summaries for TRIM54 Gene

Entrez Gene Summary for TRIM54 Gene

  • The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM54 Gene

TRIM54 (Tripartite Motif Containing 54) is a Protein Coding gene. Diseases associated with TRIM54 include cardiac rupture. GO annotations related to this gene include signal transducer activity and microtubule binding. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM54 Gene

  • May bind and stabilize microtubules during myotubes formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM54 Gene

Genomics for TRIM54 Gene

Regulatory Elements for TRIM54 Gene

Genomic Location for TRIM54 Gene

27,282,392 bp from pter
27,307,439 bp from pter
25,048 bases
Plus strand

Genomic View for TRIM54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM54 Gene

Proteins for TRIM54 Gene

  • Protein details for TRIM54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 54
    Protein Accession:
    Secondary Accessions:
    • A5D8T7
    • Q53SY4
    • Q9BYV3

    Protein attributes for TRIM54 Gene

    358 amino acids
    Molecular mass:
    40301 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.
    • Sequence=AAY24296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32841.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32842.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM54 Gene

    Alternative splice isoforms for TRIM54 Gene


neXtProt entry for TRIM54 Gene

Proteomics data for TRIM54 Gene at MOPED

Post-translational modifications for TRIM54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM54 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM54 Gene

Domains & Families for TRIM54 Gene

Suggested Antigen Peptide Sequences for TRIM54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 COS domain.
  • Contains 1 B box-type zinc finger.
  • Contains 1 COS domain.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM54: view

Function for TRIM54 Gene

Molecular function for TRIM54 Gene

UniProtKB/Swiss-Prot Function:
May bind and stabilize microtubules during myotubes formation.

Gene Ontology (GO) - Molecular Function for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0008270 zinc ion binding NAS 11243782
genes like me logo Genes that share ontologies with TRIM54: view
genes like me logo Genes that share phenotypes with TRIM54: view

Animal Models for TRIM54 Gene

MGI Knock Outs for TRIM54:

Animal Model Products

CRISPR Products

miRNA for TRIM54 Gene

miRTarBase miRNAs that target TRIM54

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM54

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TRIM54 Gene

Localization for TRIM54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM54 Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.

Subcellular locations from

Jensen Localization Image for TRIM54 Gene COMPARTMENTS Subcellular localization image for TRIM54 gene
Compartment Confidence
cytoskeleton 5
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005874 microtubule NAS 11243782
GO:0005875 microtubule associated complex IEA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with TRIM54: view

Pathways & Interactions for TRIM54 Gene

SuperPathways for TRIM54 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process NAS 11243782
GO:0007026 negative regulation of microtubule depolymerization NAS 11243782
GO:0007165 signal transduction NAS 11243782
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TRIM54: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM54 Gene

Drugs & Compounds for TRIM54 Gene

No Compound Related Data Available

Transcripts for TRIM54 Gene

mRNA/cDNA for TRIM54 Gene

Unigene Clusters for TRIM54 Gene

Tripartite motif containing 54:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM54

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM54 Gene

No ASD Table

Relevant External Links for TRIM54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM54 Gene

mRNA expression in normal human tissues for TRIM54 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM54 Gene

This gene is overexpressed in Muscle - Skeletal (x30.1), Heart - Left Ventricle (x13.0), and Heart - Atrial Appendage (x5.2).

Protein differential expression in normal tissues from HIPED for TRIM54 Gene

This gene is overexpressed in Heart (48.7) and Fetal heart (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM54 Gene

SOURCE GeneReport for Unigene cluster for TRIM54 Gene Hs.516036

mRNA Expression by UniProt/SwissProt for TRIM54 Gene

Tissue specificity: Specifically expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with TRIM54: view

Protein tissue co-expression partners for TRIM54 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM54 Gene

Orthologs for TRIM54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM54 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM54 35
  • 91.69 (n)
  • 95.8 (a)
TRIM54 36
  • 94 (a)
(Canis familiaris)
Mammalia TRIM54 35
  • 92.74 (n)
  • 98.32 (a)
TRIM54 36
  • 96 (a)
(Mus musculus)
Mammalia Trim54 35
  • 89.66 (n)
  • 95.53 (a)
Trim54 16
Trim54 36
  • 93 (a)
(Pan troglodytes)
Mammalia TRIM54 35
  • 99.44 (n)
  • 100 (a)
TRIM54 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim54 35
  • 89.57 (n)
  • 95.81 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
-- 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
(Danio rerio)
Actinopterygii trim54 35
  • 68.58 (n)
  • 68.77 (a)
trim101 36
  • 38 (a)
trim63 36
  • 50 (a)
zgc:56376 36
  • 52 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
Species with no ortholog for TRIM54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM54 Gene

Gene Tree for TRIM54 (if available)
Gene Tree for TRIM54 (if available)

Paralogs for TRIM54 Gene

(2) SIMAP similar genes for TRIM54 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM54: view

Variants for TRIM54 Gene

Sequence variations from dbSNP and Humsavar for TRIM54 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3073589 -- 27,283,820(+) cacac(-/AC)GGCCT intron-variant
rs4665376 -- 27,286,164(+) CATAT(C/T)ATTTT intron-variant
rs4665377 -- 27,300,572(+) TATta(G/T)tagta intron-variant
rs4665962 -- 27,292,237(+) AAGAC(A/G)TTGGC intron-variant
rs4665963 -- 27,305,824(+) TGGGC(C/T)CTAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM54 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
esv33516 CNV Gain 17666407
esv2719835 CNV Deletion 23290073
esv2571212 CNV Insertion 19546169

Variation tolerance for TRIM54 Gene

Residual Variation Intolerance Score: 57.24% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM54 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM54 Gene

Disorders for TRIM54 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM54 Gene - From: GeneCards

Disorder Aliases PubMed IDs
cardiac rupture
  • myocardial rupture
- elite association

Relevant External Links for TRIM54

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM54 Gene

Publications for TRIM54 Gene

  1. Muscle-specific RING finger-2 (MURF-2) is important for microtubule, intermediate filament and sarcomeric M-line maintenance in striated muscle development. (PMID: 15199100) McElhinny A.S. … Gregorio C.C. (J. Cell. Sci. 2004) 23 67
  2. Haprin, a novel haploid germ cell-specific RING finger protein involved in the acrosome reaction. (PMID: 12917430) Kitamura K. … Nishimune Y. (J. Biol. Chem. 2003) 23 67
  3. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 67

Products for TRIM54 Gene

Sources for TRIM54 Gene

Back to Top