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Aliases for TRIM54 Gene

Aliases for TRIM54 Gene

  • Tripartite Motif Containing 54 2 3
  • Muscle-Specific RING Finger Protein 3 3 4
  • Tripartite Motif-Containing 54 2 3
  • Ring Finger Protein 30 2 3
  • MURF-3 3 4
  • MuRF3 3 4
  • RNF30 3 4
  • MURF 3 4
  • Tripartite Motif-Containing Protein 54 3
  • Muscle-Specific RING-Finger Protein 3 3
  • Muscle-Specific RING Finger Protein 4
  • RING Finger Protein 30 4

External Ids for TRIM54 Gene

Previous HGNC Symbols for TRIM54 Gene

  • RNF30

Previous GeneCards Identifiers for TRIM54 Gene

  • GC02P027418
  • GC02P027506

Summaries for TRIM54 Gene

Entrez Gene Summary for TRIM54 Gene

  • The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM54 Gene

TRIM54 (Tripartite Motif Containing 54) is a Protein Coding gene. Diseases associated with TRIM54 include cardiac rupture. GO annotations related to this gene include signal transducer activity and microtubule binding. An important paralog of this gene is MID1.

UniProtKB/Swiss-Prot for TRIM54 Gene

  • May bind and stabilize microtubules during myotubes formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM54 Gene

Genomics for TRIM54 Gene

Regulatory Elements for TRIM54 Gene

Genomic Location for TRIM54 Gene

Start:
27,282,392 bp from pter
End:
27,307,439 bp from pter
Size:
25,048 bases
Orientation:
Plus strand

Genomic View for TRIM54 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM54 Gene

Proteins for TRIM54 Gene

  • Protein details for TRIM54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV2-TRI54_HUMAN
    Recommended name:
    Tripartite motif-containing protein 54
    Protein Accession:
    Q9BYV2
    Secondary Accessions:
    • A5D8T7
    • Q53SY4
    • Q9BYV3

    Protein attributes for TRIM54 Gene

    Size:
    358 amino acids
    Molecular mass:
    40301 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.
    SequenceCaution:
    • Sequence=AAY24296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32841.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32842.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM54 Gene

    Alternative splice isoforms for TRIM54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM54 Gene

Proteomics data for TRIM54 Gene at MOPED

Post-translational modifications for TRIM54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM54 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM54 Gene

Domains for TRIM54 Gene

Gene Families for TRIM54 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM54 Gene

Suggested Antigen Peptide Sequences for TRIM54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYV2

UniProtKB/Swiss-Prot:

TRI54_HUMAN :
  • Q9BYV2
Domain:
  • Contains 1 COS domain.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM54: view

Function for TRIM54 Gene

Molecular function for TRIM54 Gene

UniProtKB/Swiss-Prot Function: May bind and stabilize microtubules during myotubes formation.

Gene Ontology (GO) - Molecular Function for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0008270 zinc ion binding NAS 11243782
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM54: view
genes like me logo Genes that share phenotypes with TRIM54: view

Animal Models for TRIM54 Gene

MGI Knock Outs for TRIM54:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM54

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM54 Gene

Localization for TRIM54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM54 Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM54 Gene COMPARTMENTS Subcellular localization image for TRIM54 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm --
GO:0005874 microtubule NAS 11243782
GO:0005875 microtubule associated complex IEA --
GO:0030018 Z disc IEA --
genes like me logo Genes that share ontologies with TRIM54: view

Pathways for TRIM54 Gene

SuperPathways for TRIM54 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process NAS 11243782
GO:0007026 negative regulation of microtubule depolymerization NAS 11243782
GO:0007165 signal transduction NAS 11243782
GO:0007275 multicellular organismal development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TRIM54: view

No data available for Pathways by source for TRIM54 Gene

Transcripts for TRIM54 Gene

mRNA/cDNA for TRIM54 Gene

Unigene Clusters for TRIM54 Gene

Tripartite motif containing 54:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM54

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM54 Gene

No ASD Table

Relevant External Links for TRIM54 Gene

GeneLoc Exon Structure for
TRIM54
ECgene alternative splicing isoforms for
TRIM54

Expression for TRIM54 Gene

mRNA expression in normal human tissues for TRIM54 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM54 Gene

This gene is overexpressed in Muscle - Skeletal (30.1), Heart - Left Ventricle (13.0), and Heart - Atrial Appendage (5.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TRIM54 Gene

SOURCE GeneReport for Unigene cluster for TRIM54 Gene Hs.516036

mRNA Expression by UniProt/SwissProt for TRIM54 Gene

Q9BYV2-TRI54_HUMAN
Tissue specificity: Specifically expressed in heart and skeletal muscle.
genes like me logo Genes that share expressions with TRIM54: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM54 Gene

Orthologs for TRIM54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM54 35
  • 99.44 (n)
  • 100 (a)
TRIM54 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM54 35
  • 91.69 (n)
  • 95.8 (a)
TRIM54 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM54 35
  • 92.74 (n)
  • 98.32 (a)
TRIM54 36
  • 96 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim54 35
  • 89.66 (n)
  • 95.53 (a)
Trim54 16
Trim54 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 93 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 89 (a)
ManyToMany
-- 36
  • 47 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Trim54 35
  • 89.57 (n)
  • 95.81 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim101 36
  • 38 (a)
ManyToMany
trim54 35
  • 68.58 (n)
  • 68.77 (a)
trim63 36
  • 50 (a)
ManyToMany
zgc:56376 36
  • 52 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 52 (a)
OneToMany
Species with no ortholog for TRIM54:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM54 Gene

ENSEMBL:
Gene Tree for TRIM54 (if available)
TreeFam:
Gene Tree for TRIM54 (if available)

Paralogs for TRIM54 Gene

Selected SIMAP similar genes for TRIM54 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM54: view

Variants for TRIM54 Gene

Sequence variations from dbSNP and Humsavar for TRIM54 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1898949 -- 27,289,929(+) tgcgg(G/T)ggctt intron-variant
rs3073589 -- 27,283,820(+) cacac(-/AC)GGCCT intron-variant
rs4325713 -- 27,295,658(+) GCTCA(C/G/T)GAAGA intron-variant
rs4665376 -- 27,286,164(+) CATAT(C/T)ATTTT intron-variant
rs4665377 -- 27,300,572(+) TATta(G/T)tagta intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM54 Gene

Variant ID Type Subtype PubMed ID
nsv873754 CNV Loss 21882294
nsv833614 CNV Gain 17160897
esv33516 CNV Gain 17666407
esv2719835 CNV Deletion 23290073
esv2571212 CNV Insertion 19546169

Relevant External Links for TRIM54 Gene

HapMap Linkage Disequilibrium report
TRIM54
Human Gene Mutation Database (HGMD)
TRIM54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM54 Gene

Disorders for TRIM54 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for TRIM54 Gene including...

Search for TRIM54 Gene in MalaCards »
genes like me logo Genes that share disorders with TRIM54: view

No data available for UniProtKB/Swiss-Prot for TRIM54 Gene

Publications for TRIM54 Gene

  1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. (PMID: 17360532) Fielitz J. … Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2007) 3
  5. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PMID: 19690564) van Wijk S.J. … Timmers H.T. (Mol. Syst. Biol. 2009) 3

Products for TRIM54 Gene

Sources for TRIM54 Gene

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