Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



TRIM54 Gene

protein-coding   GIFtS: 48
GCID: GC02P027506

Tripartite Motif Containing 54

(Previous names: ring finger protein 30, tripartite motif-containing 54)
(Previous symbol: RNF30)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Tripartite Motif Containing 541 2     Muscle-Specific RING-Finger Protein 32
RING Finger Protein 301 2 3     Tripartite Motif-Containing Protein 542
RNF301 2 3     MURF33
Tripartite Motif-Containing 541 2     MuRF3
Muscle-Specific RING Finger Protein 32 3     MuRF-33
MURF2 3     MuRF33
MURF-32     Muscle-Specific RING Finger Protein3
muRF32     

External Ids:    HGNC: 160081   Entrez Gene: 571592   Ensembl: ENSG000001381007   OMIM: 6064745   UniProtKB: Q9BYV23   

Export aliases for TRIM54 gene to outside databases

Previous GC identifers: GC02P027418 GC02P027247


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for TRIM54 Gene:
The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins
RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers,
which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated
muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. (provided by
RefSeq, Jul 2008)

GeneCards Summary for TRIM54 Gene:
TRIM54 (tripartite motif containing 54) is a protein-coding gene. Diseases associated with TRIM54 include cardiac rupture, and myocardial infarction. GO annotations related to this gene include microtubule binding and signal transducer activity. An important paralog of this gene is TRIM13.

UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2
Function: May bind and stabilize microtubules during myotubes formation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM54 gene promoter:
         GR   AML1a   Lmo2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   CREB   E2F   E2F-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM54 promoter sequence
   Search Chromatin IP Primers for TRIM54

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM54


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p23.3   Ensembl cytogenetic band:  2p23.3   HGNC cytogenetic band: 2p23.3

TRIM54 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM54 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P027506:  view genomic region     (about GC identifiers)

Start:
27,505,260 bp from pter      End:
27,530,307 bp from pter
Size:
25,048 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 54  
Size: 358 amino acids; 40301 Da
Subunit: Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and
probably with TRIM55
Sequence caution: Sequence=AAY24296.1; Type=Erroneous initiation; Sequence=CAC32841.1; Type=Erroneous initiation;
Sequence=CAC32842.1; Type=Erroneous initiation;
1 PDB 3D structure from and Proteopedia for TRIM54:
3Q1D (3D)    
Secondary accessions: A5D8T7 Q53SY4 Q9BYV3
Alternative splicing: 2 isoforms:  Q9BYV2-1   Q9BYV2-2   

Explore the universe of human proteins at neXtProt for TRIM54: NX_Q9BYV2

Explore proteomics data for TRIM54 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM54 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_115935.3  NP_912730.2  

    ENSEMBL proteins: 
     ENSP00000369415   ENSP00000296098  

    TRIM54 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TRIM54
    OriGene Protein Over-expression Lysate for TRIM54
    OriGene Custom MassSpec
    OriGene Custom Protein Services for TRIM54
    GenScript Custom Purified and Recombinant Proteins Services for TRIM54
    Novus Biologicals TRIM54 Protein
    Novus Biologicals TRIM54 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM54

    TRIM54 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIM54
    Browse R&D Systems for Antibodies
    OriGene Antibodies for TRIM54
    OriGene Custom Antibody Services for TRIM54
    Novus Biologicals TRIM54 Antibodies
    Abcam antibodies for TRIM54
    Cloud-Clone Corp. Antibodies for TRIM54
    ThermoFisher Antibodies for TRIM54
    LSBio Antibodies in human, mouse, rat for TRIM54

    TRIM54 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TRIM54
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TRIM54
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TRIM54
    Cloud-Clone Corp. CLIAs for TRIM54


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    5 InterPro protein domains:
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR017903 COS_domain
     IPR000315 Znf_B-box
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q9BYV2

    ProtoNet protein and cluster: Q9BYV2

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 RING-type zinc finger


    TRIM54 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI54_HUMAN, Q9BYV2
    Function: May bind and stabilize microtubules during myotubes formation (By similarity)

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004871signal transducer activity NAS11243782
    GO:0005515protein binding ----
    GO:0008017microtubule binding IEA--
    GO:0008270zinc ion binding NAS11243782
    GO:0046872metal ion binding ----
         
    TRIM54 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIM54:
     Increased cell death in HCC-19 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trim54):
     behavior/neurological  cardiovascular system  cellular  mortality/aging  muscle 

    TRIM54 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Trim54tm1Eno for TRIM54

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM54
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM54

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM54
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM54

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TRIM54 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TRIM54:
    hsa-miR-548t hsa-miR-593
    SwitchGear 3'UTR luciferase reporter plasmidTRIM54 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM54
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM54

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM54

    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM54 (see all 9)
    OriGene ORF clones in mouse, rat for TRIM54
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM54 (NM_032546)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM54

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM54
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM54 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM54


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    TRI54_HUMAN, Q9BYV2: Cytoplasm, cytoskeleton (By similarity). Cytoplasm, myofibril, sarcomere, Z line (By
    similarity). Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus3
    cytosol2
    mitochondrion1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005874microtubule NAS11243782
    GO:0005875microtubule associated complex IEA--
    GO:0030018Z disc IEA--

    TRIM54 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM54: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM54

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRIM54 (Q9BYV23 ENSP000002960984) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TRIM63Q969Q13, ENSP000003633904I2D: score=2 STRING: ENSP00000363390
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    CKMP067323, ENSP000002214764I2D: score=1 STRING: ENSP00000221476
    UBE2IP632793, ENSP000003248974I2D: score=1 STRING: ENSP00000324897
    TRIM55Q9BYV63, ENSP000003239134I2D: score=1 STRING: ENSP00000323913
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007017microtubule-based process NAS11243782
    GO:0007026negative regulation of microtubule depolymerization NAS11243782
    GO:0007165signal transduction NAS11243782
    GO:0007275multicellular organismal development IEA--
    GO:0030154cell differentiation IEA--

    TRIM54 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM54 (TRI54)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for TRIM54 gene (2 alternative transcripts): 
    NM_032546.3  NM_187841.2  

    Unigene Cluster for TRIM54:

    Tripartite motif containing 54
    Hs.516036  [show with all ESTs]
    Unigene Representative Sequence: NM_032546
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000380075(uc002rjo.3) ENST00000296098(uc002rjn.3) ENST00000488321
    ENST00000485306
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM54 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TRIM54:
    hsa-miR-548t hsa-miR-593
    SwitchGear 3'UTR luciferase reporter plasmidTRIM54 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM54
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM54
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM54 (see all 9)
    OriGene ORF clones in mouse, rat for TRIM54
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM54 (NM_032546)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM54
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM54
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TRIM54
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM54
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM54
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM54
      QuantiFast Probe-based Assays in human, mouse, rat TRIM54

    Additional mRNA sequence: 

    AJ291714.1 AK300699.1 BC141807.1 

    5 DOTS entries:

    DT.97810288  DT.91755592  DT.91717945  DT.100739790  DT.75102302 

    Selected AceView cDNA sequences (see all 40):

    BM680943 CA417215 AI352333 BM726338 NM_032546 BU633919 AJ291714 NM_187841 
    AI971801 F26252 BF058468 AI631150 CA423690 BF941825 AA182748 AA428229 
    AA868267 CA423735 AJ403135 AI005475 AA447961 AW294748 F23238 AA625641 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    TRIM54 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACCTGGCTG
    TRIM54 Expression
    About this image

    TRIM54 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM54 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516036

    UniProtKB/Swiss-Prot: TRI54_HUMAN, Q9BYV2
    Tissue specificity: Specifically expressed in heart and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM54: 
              Ubiquitin Ligases in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TRIM54
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM54
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM54
    QuantiTect SYBR Green Assays in human, mouse, rat TRIM54
    QuantiFast Probe-based Assays in human, mouse, rat TRIM54
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM54

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for TRIM54 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim541 , 5 tripartite motif-containing 541, 5 89.66(n)1
    95.53(a)1
      5 (17.06 cM)5
    585221  NM_021447.21  NP_067422.11 
     311167125 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    38(a)
    many ↔ many
    4(156096346-156144324)
    zebrafish
    (Danio rerio)
    Actinopterygii trim541 tripartite motif-containing 54 68.58(n)
    68.77(a)
      563772  NM_001045025.2  NP_001038490.2 


    ENSEMBL Gene Tree for TRIM54 (if available)
    TreeFam Gene Tree for TRIM54 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for TRIM54 gene
    TRIM132  FSD1L2  TRIM462  TRIM632  TRIM592  TRIM92  TRIM672  TRIM362  
    TRIM552  MID12  MID22  FSD12  
    2 SIMAP similar genes for TRIM54 using alignment to 1 protein entry:     TRI54_HUMAN:
    TRIM55    TRIM63

    TRIM54 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for TRIM54 (see all 498)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165584641,2
    C,F--27505023(+) AAGAAG/AGGCCC 2 -- us2k11Minor allele frequency- A:0.06WA 118
    rs1851094501,2
    --27505386(+) ACTACA/GTGAGC 2 -- ut510--------
    rs1484948811,2
    C--27505401(+) CGAGGA/GTGCAG 2 -- ut510--------
    rs1901415031,2
    --27505435(+) AGACTG/TCTATC 2 -- ut510--------
    rs773269531,2
    C,F--27505446(+) TGGGAC/AGAGAC 2 -- ut511Minor allele frequency- A:0.05WA 118
    rs1811828611,2
    --27505525(+) GCCATC/GTAAGC 2 -- ut510--------
    rs1855781491,2
    C--27505583(+) GCCAGA/GCACGA 2 -- ut510--------
    rs1426721681,2
    C,F--27505680(+) TGCCCC/TATCTG 4 P syn11Minor allele frequency- T:0.01NA 4552
    rs1509932711,2
    C--27505741(+) TGTGCC/TGCAAA 4 R C mis10--------
    rs339949281,2
    C,F--27505758(+) AACGAC/TGTCTT 4 D syn14Minor allele frequency- T:0.05NA EU 5874

    HapMap Linkage Disequilibrium report for TRIM54 (27505260 - 27530307 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for TRIM54:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719835CNV Deletion23290073
    esv2571212CNV Insertion19546169
    nsv873754CNV Loss21882294
    nsv833614CNV Gain17160897
    esv33516CNV Gain17666407

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM54
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM54

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 606474    OMIM disorders: --

    3 diseases for TRIM54:    
    About MalaCards
    cardiac rupture    myocardial infarction    ataxia


    TRIM54 for disorders           About GeneDecksing


    Export disorders for TRIM54 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for TRIM54 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TRIM54)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PubMed id 11243782)1, 2, 3 Centner T....Labeit S. (J. Mol. Biol. 2001)
    2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W.... Wilson R.K. (Nature 2005)
    3. A microarray of ubiquitylated proteins for profiling deubiquitylase activity reveals the critical roles of both chain and substrate. (PubMed id 22626734)1 Loch C.M. and Strickler J.E. (Biochim. Biophys. Acta 2012)
    4. Comparison of an expanded ataxia interactome with patient medical records reveals a relationship between macular degeneration and ataxia. (PubMed id 21078624)1 Kahle J.J....Zoghbi H.Y. (Hum. Mol. Genet. 2011)
    5. The ubiquitin-interacting motif protein, S5a, is ubiquitinated by all types of ubiquitin ligases by a mechanism different from typical substrate recognition. (PubMed id 19240029)1 Uchiki T....Goldberg A.L. (J. Biol. Chem. 2009)
    6. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    7. Loss of muscle-specific RING-finger 3 predisposes the heart to cardiac rupture after myocardial infarction. (PubMed id 17360532)1 Fielitz J....Olson E.N. (Proc. Natl. Acad. Sci. U.S.A. 2007)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. (PubMed id 11927605)1 McElhinny A.S.... Gregorio C.C. (J. Cell Biol. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57159 HGNC: 16008 AceView: RNF30 Ensembl:ENSG00000138100 euGenes: HUgn57159
    ECgene: TRIM54 H-InvDB: TRIM54

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for TRIM54 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for TRIM54 gene:
    Search GeneIP for patents involving TRIM54

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of TRIM54
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for TRIM54   OriGene RNAi products in human, mouse, rat for TRIM54  
     OriGene qPCR primer pairs and template standards for TRIM54   OriGene Protein Over-expression Lysate for TRIM54  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for TRIM54  
     OriGene qSTAR qPCR primer pairs in human, mouse for TRIM54   OriGene Purified Protein for TRIM54  
     OriGene ORF clones in mouse, rat for TRIM54   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TRIM54   OriGene Custom Protein Services for TRIM54  

     
     
     Block miRNA regulation of human, mouse, rat TRIM54 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing TRIM54
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM54 Predesigned siRNA for gene silencing in human, mouse, rat TRIM54
     QuantiFast Probe-based Assays in human, mouse, rat TRIM54 QuantiTect SYBR Green Assays in human, mouse, rat TRIM54
     PCR Arrays including human, mouse, rat TRIM54 Search Chromatin IP Primers for TRIM54
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM54  Search GeneGlobe Interaction Network for TRIM54
     Regulatory tfbs in TRIM54 promoter
     GenScript Custom Purified and Recombinant Proteins Services for TRIM54 GenScript cDNA clones with any tag delivered in your preferred vector for TRIM54
     GenScript Custom Assay Services for TRIM54 GenScript Custom overexpressing Cell Line Services for TRIM54
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for TRIM54 (TRI54)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     TRIM54 antibodies
     TRIM54 proteins
     TRIM54 lysates
     Antibodies for TRIM54
     See all of Abcam's Antibodies, Kits and Proteins for TRIM54
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for TRIM54
     Antibodies for TRIM54
     ELISAs for TRIM54
     CLIAs for TRIM54



     Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM54
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM54
     SwitchGear 3'UTR luciferase reporter plasmids for TRIM54
     SwitchGear Promoter luciferase reporter plasmids for TRIM54
     ThermoFisher Antibodies for TRIM54
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM54
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM54
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM54
     LSBio Antibodies in human, mouse, rat for TRIM54
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      TRIM54 gene at Home site.
    Version: 3.12.166 28 Aug 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4