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Aliases for TRIM54 Gene

Aliases for TRIM54 Gene

  • Tripartite Motif Containing 54 2 3 5
  • Muscle-Specific RING Finger Protein 3 3 4
  • Ring Finger Protein 30 2 3
  • MURF-3 3 4
  • MuRF3 3 4
  • RNF30 3 4
  • MURF 3 4
  • Tripartite Motif-Containing Protein 54 3
  • Muscle-Specific RING Finger Protein 4
  • Tripartite Motif-Containing 54 2
  • RING Finger Protein 30 4

External Ids for TRIM54 Gene

Previous HGNC Symbols for TRIM54 Gene

  • RNF30

Previous GeneCards Identifiers for TRIM54 Gene

  • GC02P027418
  • GC02P027506

Summaries for TRIM54 Gene

Entrez Gene Summary for TRIM54 Gene

  • The protein encoded by this gene contains a RING finger motif and is highly similar to the ring finger proteins RNF28/MURF1 and RNF29/MURF2. In vitro studies demonstrated that this protein, RNF28, and RNF29 form heterodimers, which may be important for the regulation of titin kinase and microtubule-dependent signal pathways in striated muscles. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

GeneCards Summary for TRIM54 Gene

TRIM54 (Tripartite Motif Containing 54) is a Protein Coding gene. Diseases associated with TRIM54 include Cardiac Rupture and Cardiomyopathy, Familial Hypertrophic. GO annotations related to this gene include signal transducer activity and microtubule binding. An important paralog of this gene is TRIM55.

UniProtKB/Swiss-Prot for TRIM54 Gene

  • May bind and stabilize microtubules during myotubes formation.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM54 Gene

Genomics for TRIM54 Gene

Regulatory Elements for TRIM54 Gene

Enhancers for TRIM54 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027353 0.4 ENCODE 11.1 +71.8 71774 1.6 ATF1 PKNOX1 CREB3L1 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 SP5 MPV17 ZNF513 UCN TRIM54 NRBP1 KRTCAP3 IFT172 ATRAID SLC5A6 PREB
GH02F027091 1.1 Ensembl ENCODE 10.4 -188.3 -188278 7.0 CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 KHK EMILIN1 ABHD1 CGREF1 ATRAID SLC5A6 CAD PRR30 TCF23 PREB
GH02F027085 1.1 Ensembl ENCODE 10.4 -194.9 -194906 4.8 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
GH02F027090 0.5 Ensembl 10.4 -192.3 -192292 0.2 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
GH02F027164 0.6 ENCODE 9.9 -117.0 -117036 1.1 PKNOX1 RAD51 MTA2 IKZF1 PRDM10 SPI1 GTF3C2 PRR30 PREB ATRAID SLC5A6 ABHD1 CGREF1 CAD KHK EMILIN1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM54 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM54 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001820913 108 201 SMARCA4
ENSR00001820914 1408 2000 SAP130 RAD21 YY1 ZNF316 POLR2A PRDM10 NFE2 MAFK NFE2L2 RNF2

Genomic Location for TRIM54 Gene

Chromosome:
2
Start:
27,282,392 bp from pter
End:
27,307,439 bp from pter
Size:
25,048 bases
Orientation:
Plus strand

Genomic View for TRIM54 Gene

Genes around TRIM54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM54 Gene

Proteins for TRIM54 Gene

  • Protein details for TRIM54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BYV2-TRI54_HUMAN
    Recommended name:
    Tripartite motif-containing protein 54
    Protein Accession:
    Q9BYV2
    Secondary Accessions:
    • A5D8T7
    • Q53SY4
    • Q9BYV3

    Protein attributes for TRIM54 Gene

    Size:
    358 amino acids
    Molecular mass:
    40301 Da
    Quaternary structure:
    • Homooligomer and heterooligomer. Interacts with tubulin (By similarity). Interacts with TRIM63 and probably with TRIM55.
    SequenceCaution:
    • Sequence=AAY24296.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32841.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC32842.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for TRIM54 Gene

    Alternative splice isoforms for TRIM54 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM54 Gene

Post-translational modifications for TRIM54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM54 Gene

Domains & Families for TRIM54 Gene

Gene Families for TRIM54 Gene

Suggested Antigen Peptide Sequences for TRIM54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9BYV2

UniProtKB/Swiss-Prot:

TRI54_HUMAN :
  • Contains 1 COS domain.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 COS domain.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM54: view

Function for TRIM54 Gene

Molecular function for TRIM54 Gene

UniProtKB/Swiss-Prot Function:
May bind and stabilize microtubules during myotubes formation.

Gene Ontology (GO) - Molecular Function for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 signal transducer activity NAS 11243782
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0008270 zinc ion binding NAS 11243782
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM54: view
genes like me logo Genes that share phenotypes with TRIM54: view

Animal Models for TRIM54 Gene

MGI Knock Outs for TRIM54:

Animal Model Products

miRNA for TRIM54 Gene

miRTarBase miRNAs that target TRIM54

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM54 Gene

Localization for TRIM54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM54 Gene

Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Note=Associates with microtubules. Localizes to the Z-lines in skeletal muscles (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM54 Gene COMPARTMENTS Subcellular localization image for TRIM54 gene
Compartment Confidence
cytoskeleton 5
nucleus 3
cytosol 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005874 microtubule NAS 11243782
GO:0005875 microtubule associated complex IEA --
genes like me logo Genes that share ontologies with TRIM54: view

Pathways & Interactions for TRIM54 Gene

SuperPathways for TRIM54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007017 microtubule-based process NAS 11243782
GO:0007026 negative regulation of microtubule depolymerization NAS 11243782
GO:0007165 signal transduction NAS 11243782
GO:0007275 multicellular organism development IEA --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with TRIM54: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM54 Gene

Transcripts for TRIM54 Gene

Unigene Clusters for TRIM54 Gene

Tripartite motif containing 54:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM54 Gene

No ASD Table

Relevant External Links for TRIM54 Gene

GeneLoc Exon Structure for
TRIM54
ECgene alternative splicing isoforms for
TRIM54

Expression for TRIM54 Gene

mRNA expression in normal human tissues for TRIM54 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM54 Gene

This gene is overexpressed in Muscle - Skeletal (x30.1), Heart - Left Ventricle (x13.0), and Heart - Atrial Appendage (x5.2).

Protein differential expression in normal tissues from HIPED for TRIM54 Gene

This gene is overexpressed in Heart (48.7) and Fetal heart (20.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM54 Gene



Protein tissue co-expression partners for TRIM54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM54 Gene:

TRIM54

SOURCE GeneReport for Unigene cluster for TRIM54 Gene:

Hs.516036

mRNA Expression by UniProt/SwissProt for TRIM54 Gene:

Q9BYV2-TRI54_HUMAN
Tissue specificity: Specifically expressed in heart and skeletal muscle.
genes like me logo Genes that share expression patterns with TRIM54: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TRIM54 Gene

Orthologs for TRIM54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM54 34 35
  • 99.44 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 93 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia TRIM54 34 35
  • 92.74 (n)
cow
(Bos Taurus)
Mammalia TRIM54 34 35
  • 91.69 (n)
mouse
(Mus musculus)
Mammalia Trim54 34 16 35
  • 89.66 (n)
rat
(Rattus norvegicus)
Mammalia Trim54 34
  • 89.57 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 89 (a)
ManyToMany
-- 35
  • 47 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 38 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim54 34
  • 68.58 (n)
zgc:56376 35
  • 52 (a)
ManyToMany
trim63 35
  • 50 (a)
ManyToMany
trim101 35
  • 38 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 52 (a)
OneToMany
Species where no ortholog for TRIM54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM54 Gene

ENSEMBL:
Gene Tree for TRIM54 (if available)
TreeFam:
Gene Tree for TRIM54 (if available)

Paralogs for TRIM54 Gene

(2) SIMAP similar genes for TRIM54 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM54: view

Variants for TRIM54 Gene

Sequence variations from dbSNP and Humsavar for TRIM54 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10171831 -- 27,304,890(+) CAACC(C/T)TGGCT intron-variant
rs10175764 -- 27,300,406(+) gacct(C/G)aggtg intron-variant
rs10182053 -- 27,295,596(+) ccagc(A/G)cgcct intron-variant
rs10182973 -- 27,290,550(+) ctgag(G/T)caaga intron-variant
rs10190503 -- 27,285,372(+) CTCTA(C/T)CTTCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM54 Gene

Variant ID Type Subtype PubMed ID
esv2571212 CNV insertion 19546169
esv2719835 CNV deletion 23290073
esv33516 CNV gain 17666407
esv3590134 CNV loss 21293372
nsv833614 CNV gain 17160897
nsv955086 CNV deletion 24416366

Variation tolerance for TRIM54 Gene

Residual Variation Intolerance Score: 57.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.56; 30.23% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM54 Gene

Human Gene Mutation Database (HGMD)
TRIM54
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM54 Gene

Disorders for TRIM54 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM54 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
cardiac rupture
  • myocardial rupture
cardiomyopathy, familial hypertrophic
  • cardiomyopathy, hypertrophic, 1
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM54

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM54
genes like me logo Genes that share disorders with TRIM54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM54 Gene

Publications for TRIM54 Gene

  1. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. (PMID: 11243782) Centner T. … Labeit S. (J. Mol. Biol. 2001) 2 3 4 64
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  3. New cardiac and skeletal protein aggregate myopathy associated with combined MuRF1 and MuRF3 mutations. (PMID: 25801283) OlivAc M. … Tajsharghi H. (Hum. Mol. Genet. 2015) 3 64
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3 64
  5. The functional landscape of Hsp27 reveals new cellular processes such as DNA repair and alternative splicing and proposes novel anticancer targets. (PMID: 25277244) Katsogiannou M. … Rocchi P. (Mol. Cell Proteomics 2014) 3 64

Products for TRIM54 Gene

Sources for TRIM54 Gene

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