Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM52 Gene

Aliases for TRIM52 Gene

  • Tripartite Motif Containing 52 2 3 5
  • RING Finger Protein 102 3 4
  • RNF102 3 4
  • Tripartite Motif-Containing Protein 52 3
  • Tripartite Motif-Containing 52 2

External Ids for TRIM52 Gene

Previous GeneCards Identifiers for TRIM52 Gene

  • GC05P181677
  • GC05M180745
  • GC05M180793
  • GC05M180615
  • GC05M180682
  • GC05M175410
  • GC05M180687
  • GC05M180702

Summaries for TRIM52 Gene

GeneCards Summary for TRIM52 Gene

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. An important paralog of this gene is TRIM41.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM52 Gene

Genomics for TRIM52 Gene

Regulatory Elements for TRIM52 Gene

Enhancers for TRIM52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05G181240 1.4 ENCODE dbSUPER 36.4 +16.0 15962 9.0 CREB3L1 AGO1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 MCM3 SP3 TRIM52-AS1 ENSG00000233937 ZFP62 TRIM52 RACK1 GFPT2 ENSG00000248367 SNORD96A CNOT6 ENSG00000248514
GH05G180644 1.1 ENCODE 45.7 +615.3 615324 2.0 CREB3L1 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1 SLC30A9 TRIM52 ENSG00000233937 MAML1 CNOT6 RACK1 LOC100996419 ZFP62 FLT4 PIR50427 GC05M180610
GH05G181187 1.8 FANTOM5 ENCODE dbSUPER 22.6 +70.9 70930 6.5 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ENSG00000248514 TRIM52 TRIM7 ENSG00000233937 ENSG00000248367 SNORD96A RACK1 TRIM52-AS1 TRIM41 ZFP62
GH05G180493 1.1 ENCODE 24.1 +765.8 765794 4.2 HDGF HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ARNT ARID4B SIN3A YBX1 ZNF2 TRIM52 LOC100996419 ZFP62 CNOT6 ENSG00000248367 TBC1D9B SCGB3A1 BTNL3 LOC100329129
GH05G181172 1.6 Ensembl ENCODE dbSUPER 16.2 +87.5 87456 1.8 PKNOX1 ARNT WRNIP1 SIN3A FEZF1 ZNF2 ZNF207 FOS ZNF263 SP3 ENSG00000248514 TRIM52 ENSG00000233937 ENSG00000248367 SNORD96A RACK1 PIR55575 TRL-AAG1-3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM52 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000319008 160 3201 PKNOX1 MLX ARNT CREB3L1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B

Genomic Location for TRIM52 Gene

Chromosome:
5
Start:
181,254,417 bp from pter
End:
181,261,160 bp from pter
Size:
6,744 bases
Orientation:
Minus strand

Genomic View for TRIM52 Gene

Genes around TRIM52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM52 Gene

Proteins for TRIM52 Gene

  • Protein details for TRIM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A61-TRI52_HUMAN
    Recommended name:
    Tripartite motif-containing protein 52
    Protein Accession:
    Q96A61

    Protein attributes for TRIM52 Gene

    Size:
    297 amino acids
    Molecular mass:
    34653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM52 Gene

Post-translational modifications for TRIM52 Gene

No data available for DME Specific Peptides for TRIM52 Gene

Domains & Families for TRIM52 Gene

Gene Families for TRIM52 Gene

Suggested Antigen Peptide Sequences for TRIM52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A61

UniProtKB/Swiss-Prot:

TRI52_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM52: view

Function for TRIM52 Gene

Gene Ontology (GO) - Molecular Function for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM52: view
genes like me logo Genes that share phenotypes with TRIM52: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM52 Gene

Localization for TRIM52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM52 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM52 Gene

Pathways & Interactions for TRIM52 Gene

SuperPathways for TRIM52 Gene

No Data Available

Interacting Proteins for TRIM52 Gene

Selected Interacting proteins: Q96A61-TRI52_HUMAN for TRIM52 Gene via IID

Gene Ontology (GO) - Biological Process for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM52 Gene

Drugs & Compounds for TRIM52 Gene

No Compound Related Data Available

Transcripts for TRIM52 Gene

Unigene Clusters for TRIM52 Gene

Tripartite motif containing 52:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM52 Gene

No ASD Table

Relevant External Links for TRIM52 Gene

GeneLoc Exon Structure for
TRIM52
ECgene alternative splicing isoforms for
TRIM52

Expression for TRIM52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM52 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM52 Gene:

TRIM52

SOURCE GeneReport for Unigene cluster for TRIM52 Gene:

Hs.458412

Evidence on tissue expression from TISSUES for TRIM52 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TRIM52: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM52 Gene

Orthologs for TRIM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059672 34
  • 96.24 (n)
TRIM52 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM52 34 35
  • 85.39 (n)
cow
(Bos Taurus)
Mammalia TRIM52 34 35
  • 80.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim52 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM52 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM41 35
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM52 35
  • 9 (a)
OneToMany
Species where no ortholog for TRIM52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM52 Gene

ENSEMBL:
Gene Tree for TRIM52 (if available)
TreeFam:
Gene Tree for TRIM52 (if available)

Paralogs for TRIM52 Gene

Paralogs for TRIM52 Gene

(3) SIMAP similar genes for TRIM52 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM52: view

Variants for TRIM52 Gene

Sequence variations from dbSNP and Humsavar for TRIM52 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000112663 -- 181,261,439(+) TGGGT(C/T)GGCTG intron-variant, upstream-variant-2KB
rs1000312441 -- 181,262,176(+) CACCT(C/T)TCCTG intron-variant, upstream-variant-2KB
rs1000538403 -- 181,257,476(+) CAGAG(A/T)TGTTT intron-variant, nc-transcript-variant, reference, missense
rs1000670105 -- 181,262,625(+) ACAGA(C/G)GATGG intron-variant, upstream-variant-2KB
rs1000885399 -- 181,256,701(+) AAGAT(C/T)CCTGT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM52 Gene

Variant ID Type Subtype PubMed ID
dgv1155e214 CNV gain 21293372
dgv1156e214 CNV loss 21293372
esv3607831 CNV loss 21293372
nsv1019099 CNV loss 25217958
nsv1028730 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781

Variation tolerance for TRIM52 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.74; 96.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM52 Gene

Disorders for TRIM52 Gene

Relevant External Links for TRIM52

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM52

No disorders were found for TRIM52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM52 Gene

Publications for TRIM52 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 3 64
  4. An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family. (PMID: 24158625) Malfavon-Borja R. … Malik H.S. (Genome Biol. Evol. 2013) 3 64
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3 64

Products for TRIM52 Gene

Sources for TRIM52 Gene

Content
Loading form....