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Aliases for TRIM52 Gene

Aliases for TRIM52 Gene

  • Tripartite Motif Containing 52 2 3 5
  • RING Finger Protein 102 3 4
  • RNF102 3 4
  • Tripartite Motif-Containing Protein 52 3
  • Tripartite Motif-Containing 52 2

External Ids for TRIM52 Gene

Previous GeneCards Identifiers for TRIM52 Gene

  • GC05P181677
  • GC05M180745
  • GC05M180793
  • GC05M180615
  • GC05M180682
  • GC05M175410
  • GC05M180687
  • GC05M180702

Summaries for TRIM52 Gene

GeneCards Summary for TRIM52 Gene

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. An important paralog of this gene is TRIM41.

Additional gene information for TRIM52 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM52 Gene

Genomics for TRIM52 Gene

GeneHancer (GH) Regulatory Elements for TRIM52 Gene

Promoters and enhancers for TRIM52 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I181259 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 562.2 0.0 -25 3.6 CLOCK MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 TRIM52-AS1 TRIM52 RACK1 ENSG00000233937 SNORD96A CNOT6
GH05I181221 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 41.8 +37.9 37908 4.4 CLOCK ZFP64 YBX1 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 PIR33457 MIR4638 TRIM41 PIR62653 TRV-CAC1-5 TRK-CTT2-3 ENSG00000233937 RACK1 TRIM52 TRIM52-AS1
GH05I181187 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 41.7 +70.9 70930 6.5 MLX FEZF1 DMAP1 YY1 ZNF213 ZNF143 SP3 SSRP1 GLIS1 RCOR2 LINC01962 LOC105377769 TRP-TGG3-1 TRT-TGT6-1 TRV-AAC2-1 PIR54518 GC05M181234 GC05M181233 TRIM52 ENSG00000233937
GH05I181202 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 36.1 +55.5 55450 5.6 CLOCK ZFP64 IRF4 YY1 ZNF213 E2F8 SP3 NFYC ZNF610 GLIS1 TRIM7 ENSG00000248514 GC05P181245 PIR42038 TRA-TGC3-1 TRIM52 ENSG00000233937 ZFP62 CNOT6 RACK1
GH05I180859 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 30.3 +400.1 400135 2.4 FOXA2 PKNOX1 CLOCK ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B YY1 ZFP62 ENSG00000233937 TRIM52 SNORD96A CNOT6 MRNIP GFPT2 LINC00847 GC05P181054
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM52 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM52 gene promoter:

Genomic Locations for TRIM52 Gene

Genomic Locations for TRIM52 Gene
chr5:181,254,417-181,261,160
(GRCh38/hg38)
Size:
6,744 bases
Orientation:
Minus strand
chr5:180,681,417-180,688,119
(GRCh37/hg19)

Genomic View for TRIM52 Gene

Genes around TRIM52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM52 Gene

Proteins for TRIM52 Gene

  • Protein details for TRIM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A61-TRI52_HUMAN
    Recommended name:
    Tripartite motif-containing protein 52
    Protein Accession:
    Q96A61

    Protein attributes for TRIM52 Gene

    Size:
    297 amino acids
    Molecular mass:
    34653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM52 Gene

Post-translational modifications for TRIM52 Gene

No data available for DME Specific Peptides for TRIM52 Gene

Domains & Families for TRIM52 Gene

Gene Families for TRIM52 Gene

Suggested Antigen Peptide Sequences for TRIM52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A61

UniProtKB/Swiss-Prot:

TRI52_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM52: view

Function for TRIM52 Gene

Gene Ontology (GO) - Molecular Function for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM52: view
genes like me logo Genes that share phenotypes with TRIM52: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM52 Gene

Localization for TRIM52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM52 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (3)
  • Nucleoli (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM52 Gene

Pathways & Interactions for TRIM52 Gene

SuperPathways for TRIM52 Gene

No Data Available

Interacting Proteins for TRIM52 Gene

Selected Interacting proteins: Q96A61-TRI52_HUMAN for TRIM52 Gene via IID

Gene Ontology (GO) - Biological Process for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM52 Gene

Drugs & Compounds for TRIM52 Gene

No Compound Related Data Available

Transcripts for TRIM52 Gene

Unigene Clusters for TRIM52 Gene

Tripartite motif containing 52:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM52 Gene

No ASD Table

Relevant External Links for TRIM52 Gene

GeneLoc Exon Structure for
TRIM52
ECgene alternative splicing isoforms for
TRIM52

Expression for TRIM52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM52 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM52 Gene:

TRIM52

SOURCE GeneReport for Unigene cluster for TRIM52 Gene:

Hs.458412

Evidence on tissue expression from TISSUES for TRIM52 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TRIM52: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM52 Gene

Orthologs for TRIM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059672 33
  • 96.24 (n)
TRIM52 34
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM52 33 34
  • 85.39 (n)
cow
(Bos Taurus)
Mammalia TRIM52 33 34
  • 80.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim52 34
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM52 34
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM41 34
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM52 34
  • 9 (a)
OneToMany
Species where no ortholog for TRIM52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM52 Gene

ENSEMBL:
Gene Tree for TRIM52 (if available)
TreeFam:
Gene Tree for TRIM52 (if available)

Paralogs for TRIM52 Gene

(3) SIMAP similar genes for TRIM52 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM52: view

Variants for TRIM52 Gene

Sequence variations from dbSNP and Humsavar for TRIM52 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000112663 -- 181,261,439(-) T/C upstream_transcript_variant
rs1000312441 -- 181,262,176(-) T/C upstream_transcript_variant
rs1000538403 -- 181,257,476(-) T/A/C coding_sequence_variant, intron_variant, missense_variant
rs1000670105 -- 181,262,625(-) G/C upstream_transcript_variant
rs1000885399 -- 181,256,701(-) T/C 3_prime_UTR_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM52 Gene

Variant ID Type Subtype PubMed ID
dgv1155e214 CNV gain 21293372
dgv1156e214 CNV loss 21293372
esv3607831 CNV loss 21293372
nsv1019099 CNV loss 25217958
nsv1028730 CNV gain 25217958
nsv428133 CNV gain 18775914
nsv462591 CNV loss 19166990
nsv517697 CNV loss 19592680
nsv600731 CNV loss 21841781

Variation tolerance for TRIM52 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.74; 96.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM52 Gene

Disorders for TRIM52 Gene

Additional Disease Information for TRIM52

No disorders were found for TRIM52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM52 Gene

Publications for TRIM52 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. TRIM52: A nuclear TRIM protein that positively regulates the nuclear factor-kappa B signaling pathway. (PMID: 28073078) Fan W … Qian P (Molecular immunology 2017) 3 58
  4. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil PD … Mothes W (Journal of virology 2013) 3 58
  5. An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family. (PMID: 24158625) Malfavon-Borja R … Malik HS (Genome biology and evolution 2013) 3 58

Products for TRIM52 Gene

Sources for TRIM52 Gene

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