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Aliases for TRIM52 Gene

Aliases for TRIM52 Gene

  • Tripartite Motif Containing 52 2 3 5
  • RING Finger Protein 102 3 4
  • RNF102 3 4
  • Tripartite Motif-Containing Protein 52 3
  • Tripartite Motif-Containing 52 2

External Ids for TRIM52 Gene

Previous GeneCards Identifiers for TRIM52 Gene

  • GC05P181677
  • GC05M180745
  • GC05M180793
  • GC05M180615
  • GC05M180682
  • GC05M175410
  • GC05M180687
  • GC05M180702

Summaries for TRIM52 Gene

GeneCards Summary for TRIM52 Gene

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. An important paralog of this gene is TRIM41.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM52 Gene

Genomics for TRIM52 Gene

Regulatory Elements for TRIM52 Gene

Enhancers for TRIM52 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F181240 1.2 ENCODE 35.7 +16.0 15962 9.0 CREB3L1 DMAP1 YBX1 YY1 ZNF143 ZNF548 ZNF263 MCM3 SP3 ZNF610 ENSG00000233937 ZFP62 TRIM52-AS1 RACK1 TRIM52 SNORD96A CNOT6 GFPT2 GC05M181244 GC05M181247
GH05F180669 1 Ensembl 35.4 +591.1 591064 1.7 HDGF PKNOX1 ZNF133 ARID4B YBX1 ZNF2 GATA2 ZNF143 ZNF207 KLF7 ZFP62 ENSG00000233937 MAML1 TRIM52 LOC100996419 CNOT6 GFPT2 TBC1D9B RN7SKP150 RACK1
GH05F181202 1.2 ENCODE 26.2 +55.5 55450 5.6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 YY1 ZNF143 FOS TRIM7 RACK1 ENSG00000233937 TRIM52 ENSG00000248514 ZFP62 CNOT6 SNORD96A TRIM52-AS1 MAPK9
GH05F180493 1.1 ENCODE 23.5 +765.8 765794 4.2 HDGF PKNOX1 CREB3L1 ARID4B SIN3A YBX1 ZNF2 YY1 ZNF143 ZNF207 ZFP62 CNOT6 TRIM52 LOC100420514 OR2AI1P LOC646227 LOC100128762 LOC100419853 OR2V2 ENSG00000250765
GH05F181280 0.9 ENCODE 23.5 -20.1 -20115 1.9 TBP HDAC1 PKNOX1 CBX3 NFRKB ARID4B SIN3A NFXL1 ZBTB40 YY1 TRIM52-AS1 ZFP62 RACK1 TRIM52 ENSG00000233937 CNOT6 ENSG00000247049 TRIM41 TRIM7 ENSG00000250900
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM52 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM52 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001298651 460 4200 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 SLC30A9

Genomic Location for TRIM52 Gene

Chromosome:
5
Start:
181,254,417 bp from pter
End:
181,261,160 bp from pter
Size:
6,744 bases
Orientation:
Minus strand

Genomic View for TRIM52 Gene

Genes around TRIM52 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM52 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM52 Gene

Proteins for TRIM52 Gene

  • Protein details for TRIM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96A61-TRI52_HUMAN
    Recommended name:
    Tripartite motif-containing protein 52
    Protein Accession:
    Q96A61

    Protein attributes for TRIM52 Gene

    Size:
    297 amino acids
    Molecular mass:
    34653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM52 Gene

Post-translational modifications for TRIM52 Gene

No data available for DME Specific Peptides for TRIM52 Gene

Domains & Families for TRIM52 Gene

Gene Families for TRIM52 Gene

Suggested Antigen Peptide Sequences for TRIM52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96A61

UniProtKB/Swiss-Prot:

TRI52_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM52: view

Function for TRIM52 Gene

Gene Ontology (GO) - Molecular Function for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM52: view
genes like me logo Genes that share phenotypes with TRIM52: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM52 Gene

Localization for TRIM52 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM52 gene
Compartment Confidence
nucleus 4
cytoskeleton 2
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM52 Gene

Pathways & Interactions for TRIM52 Gene

SuperPathways for TRIM52 Gene

No Data Available

Interacting Proteins for TRIM52 Gene

Selected Interacting proteins: Q96A61-TRI52_HUMAN for TRIM52 Gene via IID

Gene Ontology (GO) - Biological Process for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM52 Gene

Transcripts for TRIM52 Gene

Unigene Clusters for TRIM52 Gene

Tripartite motif containing 52:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM52 Gene

No ASD Table

Relevant External Links for TRIM52 Gene

GeneLoc Exon Structure for
TRIM52
ECgene alternative splicing isoforms for
TRIM52

Expression for TRIM52 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM52 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM52 Gene:

TRIM52

SOURCE GeneReport for Unigene cluster for TRIM52 Gene:

Hs.458412
genes like me logo Genes that share expression patterns with TRIM52: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM52 Gene

Orthologs for TRIM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC101059672 34
  • 96.24 (n)
TRIM52 35
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM52 34 35
  • 85.39 (n)
cow
(Bos Taurus)
Mammalia TRIM52 34 35
  • 80.64 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Trim52 35
  • 48 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TRIM52 35
  • 28 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM41 35
  • 21 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 21 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TRIM52 35
  • 9 (a)
OneToMany
Species where no ortholog for TRIM52 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM52 Gene

ENSEMBL:
Gene Tree for TRIM52 (if available)
TreeFam:
Gene Tree for TRIM52 (if available)

Paralogs for TRIM52 Gene

Paralogs for TRIM52 Gene

(3) SIMAP similar genes for TRIM52 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM52: view

Variants for TRIM52 Gene

Sequence variations from dbSNP and Humsavar for TRIM52 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10063650 -- 181,258,636(+) GGGGG(G/T)TGATA intron-variant
rs10313 -- 181,255,405(+) TCTCT(A/G)GAGTA intron-variant, utr-variant-3-prime
rs1052074 -- 181,255,236(-) CTTGC(A/C)CCTTT intron-variant, utr-variant-3-prime
rs1052075 -- 181,255,227(-) TTCAC(A/C)CCACC intron-variant, utr-variant-3-prime
rs1052076 -- 181,255,224(-) ACACC(A/C)CCCAG intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TRIM52 Gene

Variant ID Type Subtype PubMed ID
nsv600731 CNV loss 21841781
nsv517697 CNV loss 19592680
nsv462591 CNV loss 19166990
nsv428133 CNV gain 18775914
nsv1028730 CNV gain 25217958
nsv1019099 CNV loss 25217958
esv3607831 CNV loss 21293372
dgv1156e214 CNV loss 21293372
dgv1155e214 CNV gain 21293372

Variation tolerance for TRIM52 Gene

Residual Variation Intolerance Score: 45.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.74; 96.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM52 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM52 Gene

Disorders for TRIM52 Gene

Relevant External Links for TRIM52

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM52

No disorders were found for TRIM52 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM52 Gene

Publications for TRIM52 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 3 64
  4. An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family. (PMID: 24158625) Malfavon-Borja R. … Malik H.S. (Genome Biol. Evol. 2013) 3 64
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3 64

Products for TRIM52 Gene

Sources for TRIM52 Gene

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