TRIM52 Gene
protein-coding GIFtS: 44
GCID: GC05M180682
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tripartite motif containing 52(Previous name: tripartite motif-containing 52 )
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Aliases
for TRIM52 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 521 2 | | RNF1021 2 3 | | Tripartite Motif-Containing 521 2 | | RING Finger Protein 1022 3 | | Tripartite Motif-Containing Protein 522 |
Export aliases for TRIM52 gene to outside databasesPrevious GC identifers: GC05P181677 GC05M180745 GC05M180793 GC05M180615 GC05M175410 |
Summaries
for TRIM52 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM52 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_023133.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM52 gene promoter:
Max1 TBP USF1 Brachyury XBP-1 USF-1 STAT3 Chx10
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM52
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM52 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q35.3 Ensembl cytogenetic band: 5q35.3 HGNC cytogenetic band: 5q35.3TRIM52 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M180682: view genomic region
(about GC identifiers)
Start:
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180,681,417 bp from pter |
End:
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180,688,119 bp from pter |
Size:
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6,703 bases |
Orientation:
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minus strand |
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Proteins
for TRIM52 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI52_HUMAN, Q96A61 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 52 Size: 297 amino acids; 34653 DaExplore the universe of human proteins at neXtProt for TRIM52: NX_Q96A61
TRIM52 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_116154.1
ENSEMBL proteins: ENSP00000332152
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM52 for ontologies About GeneDecksing
TRIM52 Antibody Products:
Assay Products for TRIM52: |
Protein
Domains /
Families
for TRIM52 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM52 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q96A61ProtoNet protein and cluster: Q96A61 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TRI52_HUMAN, Q96A61Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM52 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM52 (NM_032765) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM52 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM52 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM52 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM52 for ontologies About GeneDecksing
3 GenomeRNAi human phenotypes for TRIM52:
|
Pathways & Interactions
for TRIM52 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM52
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for TRIM52 (Q96A613 ENSP000003321524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TRIM52 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM52
Search CenterWatch for drugs/clinical trials and news about TRIM52 / TRI52
|
Transcripts
for TRIM52 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM52 gene: NM_032765.2 Unigene Cluster for TRIM52: Tripartite motif containing 52 Hs.458412 [show with all ESTs]Unigene Representative Sequence: AB2092435 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000513146 ENST00000327767(uc003mnp.3) ENST00000510796 ENST00000503005
ENST00000514805
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM52 (NM_032765) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM52 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM52 |
Additional cDNA sequence: AB209243.1 AK026706.1 AK054802.1 BC007372.2 BC034154.1 9 DOTS entries: DT.75140804 DT.95263864 DT.97767868 DT.444176 DT.100751012 DT.120826177 DT.100018872 DT.100788354 DT.95141001 24/46 AceView cDNA sequences (see all 46): AL698854 BX508861 BX484884 AI570340 AA535626 BQ011911 BQ013973 CR603450 AI926915 AL597542 CR599460 AK054802 AA564845 BM454987 AA495752 AL600062 AW440430 NM_032765 CA436362 BC007372 AA806088 AW673910 AI167267 BG055792
GeneLoc Exon Structure
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Expression
for TRIM52 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM52 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCTATCACAT
About this image
See TRIM52 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM52
SOURCE GeneReport for Unigene cluster: Hs.458412
SABiosciences Expression via Pathway-Focused PCR Array including TRIM52: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM52
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM52 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM52 |
Orthologs
for TRIM52 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM52 gene from 3/9 species (see all 9) About this table
Species with no ortholog for TRIM52
ENSEMBL Gene Tree for TRIM52 (if available)
TreeFam Gene Tree for TRIM52 (if available) |
Paralogs
for TRIM52 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM52 gene
- TRIM502 TRIM312 TRIM352 TRIM732 TRIM692 TRIM742 TRIM412 TRIM622
- TRIM722
3 SIMAP similar genes for TRIM52 using alignment to 3 protein entries: TRI52_HUMAN (see all proteins):DKFZp666N1710 TRIM41 FLJ00123
TRIM52 for paralogs About GeneDecksing
|
Genomic Variants
for TRIM52 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM52 (180681417 - 180688119 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TRIM52
1 CNV: 51657 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM52 |
|
Disorders
/ Diseases
for TRIM52 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TRIM52 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM52 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM52) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Systematic analysis of dimeric E3-RING interactions re veals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PubMed id 20596523)1 Del RincA^n S.V....Spruck C. (2010)
- Comparison of substrate specificity of the ubiquitin ligases Nedd4 and Nedd4-2 using proteome arrays. (PubMed id 19953087)1 Persaud A....Rotin D. (2009)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TRIM52 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TRIM52 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM52 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM52 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM52 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TRIM52 gene:
Search GeneIP for patents involving TRIM52
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM52 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM52 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM52 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM52 | | | OriGene Protein Over-expression Lysate for TRIM52 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM52 | | OriGene 3'-UTR Clone for TRIM52 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM52 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM52 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM52 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM52 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM52 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM52 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM52 |
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 | | | TRIM52 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM52 |
|  |  |  | | | | Search ThermoFisher Antibodies for TRIM52 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM52 |
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