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Aliases for TRIM52 Gene

Aliases for TRIM52 Gene

  • Tripartite Motif Containing 52 2 3
  • Tripartite Motif-Containing 52 2 3
  • RING Finger Protein 102 3 4
  • RNF102 3 4

External Ids for TRIM52 Gene

Previous GeneCards Identifiers for TRIM52 Gene

  • GC05P181677
  • GC05M180745
  • GC05M180793
  • GC05M180615
  • GC05M180682
  • GC05M175410
  • GC05M180687
  • GC05M180702

Summaries for TRIM52 Gene

GeneCards Summary for TRIM52 Gene

TRIM52 (Tripartite Motif Containing 52) is a Protein Coding gene. An important paralog of this gene is TRIM50.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM52 Gene

Genomics for TRIM52 Gene

Regulatory Elements for TRIM52 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TRIM52 Gene

181,254,417 bp from pter
181,261,160 bp from pter
6,744 bases
Minus strand

Genomic View for TRIM52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
GeneLoc Logo Gene Density

RefSeq DNA sequence for TRIM52 Gene

Proteins for TRIM52 Gene

  • Protein details for TRIM52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 52
    Protein Accession:

    Protein attributes for TRIM52 Gene

    297 amino acids
    Molecular mass:
    34653 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM52 Gene

Proteomics data for TRIM52 Gene at MOPED

Post-translational modifications for TRIM52 Gene

Other Protein References for TRIM52 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM52 Gene

Domains & Families for TRIM52 Gene

Protein Domains for TRIM52 Gene

Suggested Antigen Peptide Sequences for TRIM52 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM52: view

Function for TRIM52 Gene

Gene Ontology (GO) - Molecular Function for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM52: view
genes like me logo Genes that share phenotypes with TRIM52: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM52 Gene

Localization for TRIM52 Gene

Subcellular locations from

Jensen Localization Image for TRIM52 Gene COMPARTMENTS Subcellular localization image for TRIM52 gene
Compartment Confidence
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM52 Gene

Pathways & Interactions for TRIM52 Gene

SuperPathways for TRIM52 Gene

No Data Available

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Ubiquitin Ligases in human,mouse,rat

Interacting Proteins for TRIM52 Gene

Selected Interacting proteins: Q96A61-TRI52_HUMAN for TRIM52 Gene via I2D

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TRIM52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0051092 positive regulation of NF-kappaB transcription factor activity IDA 23077300
genes like me logo Genes that share ontologies with TRIM52: view

No data available for Pathways by source and SIGNOR curated interactions for TRIM52 Gene

Drugs & Compounds for TRIM52 Gene

No Compound Related Data Available

Transcripts for TRIM52 Gene

Unigene Clusters for TRIM52 Gene

Tripartite motif containing 52:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM52

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM52 Gene

No ASD Table

Relevant External Links for TRIM52 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM52 Gene

mRNA expression in normal human tissues for TRIM52 Gene

SOURCE GeneReport for Unigene cluster for TRIM52 Gene Hs.458412

genes like me logo Genes that share expression patterns with TRIM52: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM52 Gene

Orthologs for TRIM52 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM52 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM52 35
  • 80.64 (n)
  • 72.79 (a)
TRIM52 36
  • 75 (a)
(Canis familiaris)
Mammalia TRIM52 35
  • 85.39 (n)
  • 78.28 (a)
TRIM52 36
  • 68 (a)
(Pan troglodytes)
Mammalia LOC101059672 35
  • 96.24 (n)
  • 93.61 (a)
TRIM52 36
  • 96 (a)
(Monodelphis domestica)
Mammalia TRIM52 36
  • 28 (a)
(Mus musculus)
Mammalia Trim52 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 62 (a)
(Gallus gallus)
Aves TRIM41 36
  • 21 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
(Danio rerio)
Actinopterygii TRIM52 36
  • 9 (a)
Species with no ortholog for TRIM52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM52 Gene

Gene Tree for TRIM52 (if available)
Gene Tree for TRIM52 (if available)

Paralogs for TRIM52 Gene

(3) SIMAP similar genes for TRIM52 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM52: view

Variants for TRIM52 Gene

Structural Variations from Database of Genomic Variants (DGV) for TRIM52 Gene

Variant ID Type Subtype PubMed ID
nsv428133 CNV Gain 18775914
nsv883305 CNV Gain 21882294
nsv517697 CNV Loss 19592680
dgv6409n71 CNV Loss 21882294
nsv462591 CNV Loss 19166990

Variation tolerance for TRIM52 Gene

Residual Variation Intolerance Score: 45.36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 14.74; 96.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM52 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TRIM52 Gene

Disorders for TRIM52 Gene

Relevant External Links for TRIM52

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM52: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM52 Gene

Publications for TRIM52 Gene

  1. TRIM protein-mediated regulation of inflammatory and innate immune signaling and its association with antiretroviral activity. (PMID: 23077300) Uchil P.D. … Mothes W. (J. Virol. 2013) 67
  2. An evolutionary screen highlights canonical and noncanonical candidate antiviral genes within the primate TRIM gene family. (PMID: 24158625) Malfavon-Borja R. … Malik H.S. (Genome Biol. Evol. 2013) 67
  3. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Development and validation of a method for profiling post-translational modification activities using protein microarrays. (PMID: 20596523) Del RincA^n S.V. … Spruck C. (PLoS ONE 2010) 67

Products for TRIM52 Gene

Sources for TRIM52 Gene

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