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Aliases for TRIM51 Gene

Aliases for TRIM51 Gene

  • Tripartite Motif-Containing 51 2 3 5
  • SPRY Domain-Containing Protein 5 3 4
  • SPRY Domain Containing 5 2 3
  • SPRYD5 3 4
  • TRIM51A 3

External Ids for TRIM51 Gene

Previous HGNC Symbols for TRIM51 Gene

  • SPRYD5

Previous GeneCards Identifiers for TRIM51 Gene

  • GC11P057166
  • GC11P055428
  • GC11P055410
  • GC11P055651

Summaries for TRIM51 Gene

GeneCards Summary for TRIM51 Gene

TRIM51 (Tripartite Motif-Containing 51) is a Protein Coding gene. An important paralog of this gene is TRIM64C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM51 Gene

Genomics for TRIM51 Gene

Genomic Location for TRIM51 Gene

55,883,297 bp from pter
55,891,810 bp from pter
8,514 bases
Plus strand

Genomic View for TRIM51 Gene

Genes around TRIM51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM51 Gene

No data available for Regulatory Elements for TRIM51 Gene

Proteins for TRIM51 Gene

  • Protein details for TRIM51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 51
    Protein Accession:
    Secondary Accessions:
    • A6NMG2

    Protein attributes for TRIM51 Gene

    452 amino acids
    Molecular mass:
    52285 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH05014.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM51 Gene


neXtProt entry for TRIM51 Gene

Proteomics data for TRIM51 Gene at MOPED

Post-translational modifications for TRIM51 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM51 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TRIM51 Gene

Domains & Families for TRIM51 Gene

Gene Families for TRIM51 Gene

Suggested Antigen Peptide Sequences for TRIM51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM51: view

Function for TRIM51 Gene

genes like me logo Genes that share phenotypes with TRIM51: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM51 Gene

Localization for TRIM51 Gene

Subcellular locations from

Jensen Localization Image for TRIM51 Gene COMPARTMENTS Subcellular localization image for TRIM51 gene
Compartment Confidence
nucleus 3
cytosol 2
endoplasmic reticulum 1
extracellular 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM51 Gene

Pathways & Interactions for TRIM51 Gene

SuperPathways for TRIM51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM51 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM51 Gene

Drugs & Compounds for TRIM51 Gene

No Compound Related Data Available

Transcripts for TRIM51 Gene

mRNA/cDNA for TRIM51 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM51 Gene

Tripartite motif-containing 51:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM51 Gene

No ASD Table

Relevant External Links for TRIM51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM51 Gene

mRNA expression in normal human tissues for TRIM51 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM51 Gene

This gene is overexpressed in Testis (x29.1), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for TRIM51 Gene

This gene is overexpressed in Bone marrow stromal cell (60.0) and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM51 Gene

SOURCE GeneReport for Unigene cluster for TRIM51 Gene Hs.326734

genes like me logo Genes that share expression patterns with TRIM51: view

Protein tissue co-expression partners for TRIM51 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM51 Gene

Orthologs for TRIM51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM51 Gene

Organism Taxonomy Gene Similarity Type Details
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 19 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 30 (a)
-- 36
  • 26 (a)
-- 36
  • 25 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 16 (a)
(Pan troglodytes)
Mammalia TRIM51 36
  • 93 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 26 (a)
-- 36
  • 31 (a)
-- 36
  • 20 (a)
-- 36
  • 21 (a)
-- 36
  • 23 (a)
-- 36
  • 24 (a)
-- 36
  • 30 (a)
(Danio rerio)
Actinopterygii trim109 36
  • 20 (a)
Species with no ortholog for TRIM51:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM51 Gene

Gene Tree for TRIM51 (if available)
Gene Tree for TRIM51 (if available)

Paralogs for TRIM51 Gene

genes like me logo Genes that share paralogs with TRIM51: view

Variants for TRIM51 Gene

Sequence variations from dbSNP and Humsavar for TRIM51 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2063276 -- 55,885,487(+) CATGA(A/G)CTACT reference, missense
rs2063277 -- 55,885,495(+) ACTTC(A/C)TAGAC reference, missense
rs3862669 -- 55,887,680(+) CCCCA(A/G)TTCTC intron-variant
rs3862670 -- 55,888,456(+) TACTT(C/T)ATCCA intron-variant
rs4341561 -- 55,882,571(+) GTTCC(A/G)GCTTT upstream-variant-2KB

Variation tolerance for TRIM51 Gene

Gene Damage Index Score: 5.25; 70.14% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM51 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM51 Gene

Disorders for TRIM51 Gene

Relevant External Links for TRIM51

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM51 Gene

Publications for TRIM51 Gene

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K. … Sawyer S.L. (PLoS Genet. 2011) 3 67
  2. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRIM51 Gene

Sources for TRIM51 Gene

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