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Aliases for TRIM51 Gene

Aliases for TRIM51 Gene

  • Tripartite Motif-Containing 51 2 3 5
  • SPRY Domain-Containing Protein 5 3 4
  • SPRY Domain Containing 5 2 3
  • SPRYD5 3 4
  • Tripartite Motif-Containing Protein 51 3
  • TRIM51A 3

External Ids for TRIM51 Gene

Previous HGNC Symbols for TRIM51 Gene

  • SPRYD5

Previous GeneCards Identifiers for TRIM51 Gene

  • GC11P057166
  • GC11P055428
  • GC11P055410
  • GC11P055651

Summaries for TRIM51 Gene

GeneCards Summary for TRIM51 Gene

TRIM51 (Tripartite Motif-Containing 51) is a Protein Coding gene. An important paralog of this gene is TRIM49B.

Additional gene information for TRIM51 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM51 Gene

Genomics for TRIM51 Gene

GeneHancer (GH) Regulatory Elements for TRIM51 Gene

Promoters and enhancers for TRIM51 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I055883 Promoter 0.5 EPDnew 550.8 -0.1 -87 0.1 TRIM51 LOC100507561
GH11I055430 Enhancer 0.2 FANTOM5 1.3 -453.0 -452966 0 GC11P055434 OR4A10P GC11P055433 OR5D14 OR5D18 OR4C15 OR5L2 OR4C16 OR5D16 OR4C6
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM51 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TRIM51 Gene

Genomic Locations for TRIM51 Gene
8,514 bases
Plus strand

Genomic View for TRIM51 Gene

Genes around TRIM51 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM51 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM51 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM51 Gene

Proteins for TRIM51 Gene

  • Protein details for TRIM51 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 51
    Protein Accession:
    Secondary Accessions:
    • A6NMG2

    Protein attributes for TRIM51 Gene

    452 amino acids
    Molecular mass:
    52285 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH05014.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TRIM51 Gene


neXtProt entry for TRIM51 Gene

Post-translational modifications for TRIM51 Gene

No Post-translational modifications

Other Protein References for TRIM51 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM51 Gene

Domains & Families for TRIM51 Gene

Gene Families for TRIM51 Gene

Suggested Antigen Peptide Sequences for TRIM51 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM51: view

Function for TRIM51 Gene

Gene Ontology (GO) - Molecular Function for TRIM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM51: view
genes like me logo Genes that share phenotypes with TRIM51: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM51 Gene

Localization for TRIM51 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM51 gene
Compartment Confidence
nucleus 3
cytosol 2
plasma membrane 1
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM51 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM51: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM51 Gene

Pathways & Interactions for TRIM51 Gene

SuperPathways for TRIM51 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM51 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM51 Gene

Drugs & Compounds for TRIM51 Gene

No Compound Related Data Available

Transcripts for TRIM51 Gene

mRNA/cDNA for TRIM51 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM51 Gene

Tripartite motif-containing 51:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM51 Gene

No ASD Table

Relevant External Links for TRIM51 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM51 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM51 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM51 Gene

This gene is overexpressed in Testis (x29.1), Brain - Anterior cingulate cortex (BA24) (x5.3), Brain - Frontal Cortex (BA9) (x5.2), and Brain - Cortex (x5.1).

Protein differential expression in normal tissues from HIPED for TRIM51 Gene

This gene is overexpressed in Bone marrow stromal cell (60.0) and Heart (9.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM51 Gene

Protein tissue co-expression partners for TRIM51 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM51 Gene:


SOURCE GeneReport for Unigene cluster for TRIM51 Gene:

genes like me logo Genes that share expression patterns with TRIM51: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM51 Gene

Orthologs for TRIM51 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM51 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM51 34
  • 93 (a)
(Monodelphis domestica)
Mammalia -- 34
  • 33 (a)
-- 34
  • 30 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 29 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 28 (a)
-- 34
  • 26 (a)
-- 34
  • 25 (a)
-- 34
  • 19 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 31 (a)
-- 34
  • 30 (a)
-- 34
  • 26 (a)
-- 34
  • 24 (a)
-- 34
  • 23 (a)
-- 34
  • 21 (a)
-- 34
  • 20 (a)
(Danio rerio)
Actinopterygii trim109 34
  • 20 (a)
Species where no ortholog for TRIM51 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM51 Gene

Gene Tree for TRIM51 (if available)
Gene Tree for TRIM51 (if available)

Paralogs for TRIM51 Gene

Variants for TRIM51 Gene

Sequence variations from dbSNP and Humsavar for TRIM51 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000275832 -- 55,883,238(+) GAGGAGGA/GAGGA upstream_transcript_variant
rs1000644677 -- 55,882,247(+) A/C upstream_transcript_variant
rs1000710829 -- 55,883,368(+) A/T 5_prime_UTR_variant
rs1001004660 -- 55,887,366(+) A/G intron_variant
rs1001015383 -- 55,882,004(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM51 Gene

Variant ID Type Subtype PubMed ID
dgv1205n100 CNV gain 25217958
dgv1905n54 CNV gain 21841781
esv2751030 CNV gain 17911159
esv3579771 CNV gain 25503493
esv3579782 CNV gain 25503493
esv3626458 CNV gain 21293372
esv3892013 CNV gain 25118596
nsv1044174 CNV loss 25217958
nsv555077 CNV loss 21841781
nsv821668 CNV loss 15273396
nsv832158 CNV gain 17160897
nsv972028 CNV duplication 23825009

Variation tolerance for TRIM51 Gene

Gene Damage Index Score: 5.25; 70.14% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM51 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM51 Gene

Disorders for TRIM51 Gene

Additional Disease Information for TRIM51

No disorders were found for TRIM51 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM51 Gene

Publications for TRIM51 Gene

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K … Sawyer SL (PLoS genetics 2011) 3 58
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor TD … Sakaki Y (Nature 2006) 4 58
  3. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual JF … Vidal M (Nature 2005) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TRIM51 Gene

Sources for TRIM51 Gene

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