Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM50 Gene

Aliases for TRIM50 Gene

  • Tripartite Motif Containing 50 2 3 5
  • Tripartite Motif-Containing Protein 50 3 4
  • Tripartite Motif-Containing 50A 2 3
  • TRIM50A 3 4
  • Tripartite Motif-Containing 50 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for TRIM50 Gene

Previous HGNC Symbols for TRIM50 Gene

  • TRIM50A

Previous GeneCards Identifiers for TRIM50 Gene

  • GC07M072124
  • GC07M072364
  • GC07M072726
  • GC07M068608

Summaries for TRIM50 Gene

GeneCards Summary for TRIM50 Gene

TRIM50 (Tripartite Motif Containing 50) is a Protein Coding gene. Diseases associated with TRIM50 include Williams-Beuren Syndrome. Among its related pathways are Antigen processing- Ubiquitination and Proteasome degradation and Immune System. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM73.

UniProtKB/Swiss-Prot for TRIM50 Gene

  • E3 ubiquitin-protein ligase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM50 Gene

Genomics for TRIM50 Gene

Regulatory Elements for TRIM50 Gene

Enhancers for TRIM50 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM50 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM50 Gene

73,312,472 bp from pter
73,328,279 bp from pter
15,808 bases
Minus strand

Genomic View for TRIM50 Gene

Genes around TRIM50 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM50 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM50 Gene

Proteins for TRIM50 Gene

  • Protein details for TRIM50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    E3 ubiquitin-protein ligase TRIM50
    Protein Accession:
    Secondary Accessions:
    • Q86XT3

    Protein attributes for TRIM50 Gene

    487 amino acids
    Molecular mass:
    54774 Da
    Quaternary structure:
    • Can form dimers and trimers. Interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3. No interaction with UBE2H.

    Alternative splice isoforms for TRIM50 Gene


neXtProt entry for TRIM50 Gene

Proteomics data for TRIM50 Gene at MOPED

Selected DME Specific Peptides for TRIM50 Gene

Post-translational modifications for TRIM50 Gene

Other Protein References for TRIM50 Gene

Domains & Families for TRIM50 Gene

Gene Families for TRIM50 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM50: view

Function for TRIM50 Gene

Molecular function for TRIM50 Gene

UniProtKB/Swiss-Prot Function:
E3 ubiquitin-protein ligase.

Enzyme Numbers (IUBMB) for TRIM50 Gene

Gene Ontology (GO) - Molecular Function for TRIM50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016874 ligase activity IEA --
genes like me logo Genes that share ontologies with TRIM50: view
genes like me logo Genes that share phenotypes with TRIM50: view

Animal Models for TRIM50 Gene

MGI Knock Outs for TRIM50:

Animal Model Products

miRNA for TRIM50 Gene

miRTarBase miRNAs that target TRIM50

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM50 Gene

Localization for TRIM50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM50 Gene


Subcellular locations from

Jensen Localization Image for TRIM50 Gene COMPARTMENTS Subcellular localization image for TRIM50 gene
Compartment Confidence
nucleus 3
cytosol 2

No data available for Gene Ontology (GO) - Cellular Components for TRIM50 Gene

Pathways & Interactions for TRIM50 Gene

genes like me logo Genes that share pathways with TRIM50: view

Interacting Proteins for TRIM50 Gene

Gene Ontology (GO) - Biological Process for TRIM50 Gene


No data available for SIGNOR curated interactions for TRIM50 Gene

Drugs & Compounds for TRIM50 Gene

No Compound Related Data Available

Transcripts for TRIM50 Gene

Unigene Clusters for TRIM50 Gene

Tripartite motif containing 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM50 Gene

No ASD Table

Relevant External Links for TRIM50 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM50 Gene

mRNA expression in normal human tissues for TRIM50 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM50 Gene

This gene is overexpressed in Stomach (x23.3), Pancreas (x16.6), and Testis (x5.6).

SOURCE GeneReport for Unigene cluster for TRIM50 Gene Hs.647053

genes like me logo Genes that share expression patterns with TRIM50: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM50 Gene

Orthologs for TRIM50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM50 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM50 35
  • 89.51 (n)
  • 91.36 (a)
TRIM50 36
  • 91 (a)
(Canis familiaris)
Mammalia TRIM50 35
  • 88.48 (n)
  • 89.71 (a)
-- 36
  • 89 (a)
(Mus musculus)
Mammalia Trim50 35
  • 84.4 (n)
  • 89.1 (a)
Trim50 16
Trim50 36
  • 88 (a)
(Pan troglodytes)
Mammalia TRIM50 35
  • 99.04 (n)
  • 99.18 (a)
TRIM50 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Trim50 35
  • 84.76 (n)
  • 88.46 (a)
(Gallus gallus)
Aves TRIM50 35
  • 66.47 (n)
  • 59.11 (a)
-- 36
  • 60 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia trim50 35
  • 59.48 (n)
  • 57.08 (a)
Species with no ortholog for TRIM50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM50 Gene

Gene Tree for TRIM50 (if available)
Gene Tree for TRIM50 (if available)

Paralogs for TRIM50 Gene

Paralogs for TRIM50 Gene

(11) SIMAP similar genes for TRIM50 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM50: view

Variants for TRIM50 Gene

Sequence variations from dbSNP and Humsavar for TRIM50 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs6980124 - 73,324,765(+) GCTCC(A/G)GCAGG intron-variant, reference, missense
rs6949855 -- 73,314,130(+) GCCAA(A/G)GGGAA intron-variant
rs6950193 -- 73,314,271(+) TGTGC(A/C)ATGGT intron-variant
rs13227775 -- 73,323,095(+) TCCCA(C/T)CGACT intron-variant
rs13227882 -- 73,323,179(+) AGCAT(G/T)TCATC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM50 Gene

Variant ID Type Subtype PubMed ID
dgv2095e1 CNV Complex 17122850
nsv520573 CNV Gain+Loss 19592680
esv34349 CNV Gain 17911159
dgv2099e1 CNV Complex 17122850
nsv888362 CNV Gain 21882294
esv2734660 CNV Deletion 23290073
nsv831027 CNV Loss 17160897
dgv7324n71 CNV Gain 21882294

Variation tolerance for TRIM50 Gene

Residual Variation Intolerance Score: 86.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.00; 36.96% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM50 Gene

Disorders for TRIM50 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TRIM50 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
williams-beuren syndrome
  • fanconi schlesinger syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TRIM50

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TRIM50: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM50 Gene

Publications for TRIM50 Gene

  1. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4 67
  2. HDAC6 mediates the acetylation of TRIM50. (PMID: 24308962) Fusco C. … Merla G. (Cell. Signal. 2014) 3
  3. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  4. The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. (PMID: 22792322) Fusco C. … Merla G. (PLoS ONE 2012) 3
  5. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PMID: 21143188) Napolitano L.M. … Meroni G. (Biochem. J. 2011) 3

Products for TRIM50 Gene

Sources for TRIM50 Gene