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Aliases for TRIM50 Gene

Aliases for TRIM50 Gene

  • Tripartite Motif Containing 50 2 3
  • TRIM50A 3 4 6
  • Tripartite Motif-Containing Protein 50 3 4
  • Tripartite Motif-Containing 50A 2 3
  • E3 Ubiquitin-Protein Ligase TRIM50 3
  • Tripartite Motif-Containing 50 2
  • EC 6.3.2.- 4
  • EC 6.3.2 63

External Ids for TRIM50 Gene

Previous HGNC Symbols for TRIM50 Gene

  • TRIM50A

Previous GeneCards Identifiers for TRIM50 Gene

  • GC07M072124
  • GC07M072364
  • GC07M072726
  • GC07M068608

Summaries for TRIM50 Gene

GeneCards Summary for TRIM50 Gene

TRIM50 (Tripartite Motif Containing 50) is a Protein Coding gene. GO annotations related to this gene include ligase activity. An important paralog of this gene is TRIM35.

UniProtKB/Swiss-Prot for TRIM50 Gene

  • E3 ubiquitin-protein ligase.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM50 Gene

Genomics for TRIM50 Gene

Regulatory Elements for TRIM50 Gene

Genomic Location for TRIM50 Gene

Start:
73,312,536 bp from pter
End:
73,328,082 bp from pter
Size:
15,547 bases
Orientation:
Minus strand

Genomic View for TRIM50 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM50 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM50 Gene

Proteins for TRIM50 Gene

  • Protein details for TRIM50 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86XT4-TRI50_HUMAN
    Recommended name:
    E3 ubiquitin-protein ligase TRIM50
    Protein Accession:
    Q86XT4
    Secondary Accessions:
    • Q86XT3

    Protein attributes for TRIM50 Gene

    Size:
    487 amino acids
    Molecular mass:
    54774 Da
    Quaternary structure:
    • Can form dimers and trimers. Interacts with several E2 ubiquitin-conjugating enzymes, including UBE2L6, UBE2E1, UBE2E3. No interaction with UBE2H.

    Alternative splice isoforms for TRIM50 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM50 Gene

Proteomics data for TRIM50 Gene at MOPED

Selected DME Specific Peptides for TRIM50 Gene

Post-translational modifications for TRIM50 Gene

Other Protein References for TRIM50 Gene

Domains for TRIM50 Gene

Gene Families for TRIM50 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Graphical View of Domain Structure for InterPro Entry

Q86XT4

UniProtKB/Swiss-Prot:

TRI50_HUMAN :
  • Q86XT4
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM50: view

Function for TRIM50 Gene

Molecular function for TRIM50 Gene

UniProtKB/Swiss-Prot Function: E3 ubiquitin-protein ligase.

Enzyme Numbers (IUBMB) for TRIM50 Gene

Gene Ontology (GO) - Molecular Function for TRIM50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding --
genes like me logo Genes that share ontologies with TRIM50: view

Phenotypes for TRIM50 Gene

MGI mutant phenotypes for TRIM50:
inferred from 2 alleles
GenomeRNAi human phenotypes for TRIM50:
genes like me logo Genes that share phenotypes with TRIM50: view

Animal Models for TRIM50 Gene

MGI Knock Outs for TRIM50:

miRNA for TRIM50 Gene

miRTarBase miRNAs that target TRIM50

No data available for Transcription Factor Targeting and HOMER Transcription for TRIM50 Gene

Localization for TRIM50 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM50 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM50 Gene COMPARTMENTS Subcellular localization image for TRIM50 gene
Compartment Confidence
nucleus 3
cytosol 2

Gene Ontology (GO) - Cellular Components for TRIM50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with TRIM50: view

Pathways for TRIM50 Gene

SuperPathways for TRIM50 Gene

No Data Available

Interacting Proteins for TRIM50 Gene

Gene Ontology (GO) - Biological Process for TRIM50 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with TRIM50: view

No data available for Pathways by source for TRIM50 Gene

Transcripts for TRIM50 Gene

Unigene Clusters for TRIM50 Gene

Tripartite motif containing 50:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM50 Gene

No ASD Table

Relevant External Links for TRIM50 Gene

GeneLoc Exon Structure for
TRIM50
ECgene alternative splicing isoforms for
TRIM50

Expression for TRIM50 Gene

mRNA expression in normal human tissues for TRIM50 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM50 Gene

This gene is overexpressed in Stomach (23.3), Pancreas (16.6), and Testis (5.6).

SOURCE GeneReport for Unigene cluster for TRIM50 Gene Hs.647053

genes like me logo Genes that share expressions with TRIM50: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TRIM50 Gene

Orthologs for TRIM50 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM50 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM50 35
  • 99.04 (n)
  • 99.18 (a)
TRIM50 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TRIM50 35
  • 89.51 (n)
  • 91.36 (a)
TRIM50 36
  • 91 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 89 (a)
OneToMany
TRIM50 35
  • 88.48 (n)
  • 89.71 (a)
mouse
(Mus musculus)
Mammalia Trim50 35
  • 84.4 (n)
  • 89.1 (a)
Trim50 16
Trim50 36
  • 88 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trim50 35
  • 84.76 (n)
  • 88.46 (a)
chicken
(Gallus gallus)
Aves -- 36
  • 60 (a)
OneToMany
TRIM50 35
  • 66.47 (n)
  • 59.11 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia trim50 35
  • 59.48 (n)
  • 57.08 (a)
Species with no ortholog for TRIM50:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM50 Gene

ENSEMBL:
Gene Tree for TRIM50 (if available)
TreeFam:
Gene Tree for TRIM50 (if available)

Paralogs for TRIM50 Gene

Selected SIMAP similar genes for TRIM50 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with TRIM50: view

Variants for TRIM50 Gene

Sequence variations from dbSNP and Humsavar for TRIM50 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2353062 -- 73,326,044(+) CACCA(C/T)GCCAA intron-variant, upstream-variant-2KB
rs2463283 -- 73,319,744(+) ACTTC(A/G)GGAGA intron-variant
rs2463284 -- 73,319,867(+) AGTCA(C/T)GCCCA intron-variant
rs2463285 -- 73,320,088(+) CTGAG(C/T)TCTAC intron-variant
rs2530528 -- 73,319,071(+) GGCTG(C/G)TCACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM50 Gene

Variant ID Type Subtype PubMed ID
dgv2095e1 CNV Complex 17122850
nsv520573 CNV Gain+Loss 19592680
esv34349 CNV Gain 17911159
dgv2099e1 CNV Complex 17122850
nsv888362 CNV Gain 21882294
esv2734660 CNV Deletion 23290073
nsv831027 CNV Loss 17160897
dgv7324n71 CNV Gain 21882294

Relevant External Links for TRIM50 Gene

HapMap Linkage Disequilibrium report
TRIM50

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM50 Gene

Disorders for TRIM50 Gene

(1) University of Copenhagen DISEASES for TRIM50 Gene

genes like me logo Genes that share disorders with TRIM50: view

No data available for UniProtKB/Swiss-Prot for TRIM50 Gene

Publications for TRIM50 Gene

  1. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  2. Williams-Beuren syndrome TRIM50 encodes an E3 ubiquitin ligase. (PMID: 18398435) Micale L. … Reymond A. (Eur. J. Hum. Genet. 2008) 3 4
  3. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PMID: 21143188) Napolitano L.M. … Meroni G. (Biochem. J. 2011) 3
  4. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PMID: 22610502) Kennedy R.B. … Poland G.A. (Hum. Genet. 2012) 3
  5. The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. (PMID: 22792322) Fusco C. … Merla G. (PLoS ONE 2012) 3

Products for TRIM50 Gene

Sources for TRIM50 Gene

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