TRIM5 Gene
protein-coding GIFtS: 55
GCID: GC11M005641
|
|
tripartite motif containing 5(Previous name: tripartite motif-containing 5 )
| |
Aliases
for TRIM5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA
Quality score for the ORGUL clustered with this gene is 3
| Aliases |
|---|
| Tripartite Motif Containing 51 2 | | Tripartite Motif Containing 5 Transcript Variant Kappa2 | | RNF881 2 3 5 | | Tripartite Motif Protein TRIM52 | | TRIM5alpha1 2 | | Tripartite Motif-Containing Protein 52 | | RING Finger Protein 882 3 | | EC 6.3.2.-3 | | Tripartite Motif-Containing 51 | | EC 6.3.28 | | Tripartite Motif Containing 5 Transcript Variant Iota2 | | |
| External Ids: | HGNC: 162761 | Entrez Gene: 853632 | Ensembl: ENSG000001322567 | OMIM: 6084875 | UniProtKB: Q9C0353 |
|---|
| | ORGUL members: | |
|---|
| NONCODE:n342750 | |
Export aliases for TRIM5 gene to outside databasesPrevious GC identifers: GC11M006432 GC11M005986 GC11M005643 GC11M005649 GC11M005345
Summaries
for TRIM5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM5:
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein formshomo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviralrestriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described forthis gene. (provided by RefSeq, Dec 2009)
UniProtKB/Swiss-Prot: TRIM5_HUMAN, Q9C035Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viralreplication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as acapsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signalingin response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity,and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1Acomplex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of theMAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylationresults in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to aninnate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equineinfectious anemia virus (EIAV)
Gene Wiki entry for TRIM5 (TRIM5alpha)
|
Genomic Views
for TRIM5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_009237.18
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM5 gene promoter:
c-Fos AP-1 p53 JunB Fra-1 FosB IRF-1 IRF-2 JunD c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM5
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM5 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p15 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15TRIM5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M005641: view genomic region
(about GC identifiers)
Start:
|
5,684,425 bp from pter |
End:
|
5,959,849 bp from pter |
Size:
|
275,425 bases |
Orientation:
|
minus strand |
|
Proteins
for TRIM5 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRIM5_HUMAN, Q9C035 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 5 Size: 493 amino acids; 56338 Da
Subunit: Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-ordermultimerization and both low- and high-order multimerizations are essential for its restriction activity. IsoformDelta interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70 (By similarity). Interacts(via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, SQSTM1, MAP3K7/TAK1, TAB2 and TAB3
Subcellular location: Cytoplasm, P-body. Note=Closely associates with proteasomal subunits in cytoplasmic bodies (Bysimilarity). Co-localizes with SQSTM1 in cytoplasmic bodies
2 PDB 3D structures from  and Proteopedia  for TRIM5:2ECV (3D)
2YRG (3D)
Secondary accessions: A6NGQ1 A8WFA8 D3DQS8 D3DQS9 G3GJY1 Q2MLV4 Q2MLV8 Q2MLV9 Q2MLW1 Q2MLW3 Q2MLW4Q2MLW6 Q2MLW7 Q2MLX1 Q2MLX2 Q2MLX3 Q2MLX5 Q2MLY3 Q2MLY4 Q2V6Q6 Q6GX26 Q8WU46 Q96SR5 Q9C031 Q9C032Q9C033 Q9C034Alternative splicing: 6 isoforms: Q9C035-1 Q9C035-2 Q9C035-3 Q9C035-4 Q9C035-5 Q9C035-6 (Has dominant-negative activity against TRIM5alpha. Does not inhibit HIV-1 replication)Explore the universe of human proteins at neXtProt for TRIM5: NX_Q9C035
Post-translational modifications:
Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashionfollowing exposure to restriction sensitive virus1
Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated byYersinia YopJ. Ubiquitination may not lead to proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9C035
4/34 DME Specific Peptides for TRIM5 (Q9C035) (see all 34)
TRIM5 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_149023.2 NP_149083.2 NP_149084.2
ENSEMBL proteins: ENSP00000369373 ENSP00000369366 ENSP00000393052 ENSP00000380058 ENSP00000398196 ENSP00000388031 ENSP00000388150 ENSP00000380064 ENSP00000380062 ENSP00000307031
Human Recombinant Protein Products for TRIM5:
Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table
TRIM5 for ontologies About GeneDecksing
TRIM5 Antibody Products:
Assay Products for TRIM5: |
Protein
Domains /
Families
for TRIM5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM5 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q9C035ProtoNet protein and cluster: Q9C035 2 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger
UniProtKB/Swiss-Prot: TRIM5_HUMAN, Q9C035Domain: The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low ordermultimerization respectively which is essential for restriction activity (PubMed:22482711)Domain: The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observedspecies-specific differences among orthologs (PubMed:22482711)Domain: The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirusrestriction activity, autoubiquitination and higher-order multimerization (PubMed:22482711)Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM5 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TRIM5_HUMAN, Q9C035Function: Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viralreplication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as acapsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signalingin response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity,and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1Acomplex) generates 'Lys-63'-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of theMAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylationresults in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to aninnate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV) and equineinfectious anemia virus (EIAV) Enzyme Numbers (IUBMB): EC 6.3.2.-1 EC 6.3.22
Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7): About this table
TRIM5 for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM5 (NM_015431) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM5 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM5 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM5 |
|
Pathways & Interactions
for TRIM5 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
UniProtKB/Swiss-Prot: TRIM5_HUMAN, Q9C035Pathway: Protein modification; protein ubiquitinationInteractions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for TRIM5
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/33 Interacting proteins for TRIM5 (Q9C0351, 3 ENSP000003693734) via UniProtKB, MINT, STRING, and/or I2D (see all 33) About this table
Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0002218 | activation of innate immune response |
IDA | -- | | GO:0002221 | pattern recognition receptor signaling pathway |
IDA | -- | | GO:0009615 | response to virus |
-- | -- | | GO:0016567 | protein ubiquitination |
-- | -- | | GO:0019048 | virus-host interaction |
IEA | -- |
TRIM5 for ontologies About GeneDecksing
|
Drugs & Compounds
for TRIM5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
TRIM5 for compounds About GeneDecksing
 Browse Tocris compounds for TRIM5
4 HMDB Compounds for TRIM5 About this table
2 Novoseek chemical compound relationships for TRIM5 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| arsenite |
43.3 |
1 |
19886997 (1) |
| cyclosporin a |
31.2 |
7 |
16641261 (2), 19886997 (1) |
Search CenterWatch for drugs/clinical trials and news about TRIM5
|
Transcripts
for TRIM5 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM5 gene (3 alternative transcripts): NM_033034.2 NM_033092.2 NM_033093.2 Unigene Cluster for TRIM5: Tripartite motif containing 5 Hs.125300 [show with all ESTs]Unigene Representative Sequence: BX64715214 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000380034 ENST00000380027 ENST00000433961 ENST00000396847 ENST00000438025
ENST00000483835 ENST00000492086 ENST00000465634 ENST00000487241 ENST00000412903(uc001mbq.1)
ENST00000419850 ENST00000396855(uc001mbn.3) ENST00000396853(uc021qcx.1)
ENST00000305836(uc001mbl.2 uc001mbm.2 uc001mbp.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM5 (NM_015431) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM5 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM5 |
Additional cDNA sequence: AB362928.1 AF220025.1 AF220026.1 AF220027.1 AF220028.1 AK027593.1 AK074363.1 AY625000.1 BC020770.1 BC021258.2 BX647152.1 DQ288685.1 JF928461.1 JF928462.1 20 DOTS entries: DT.95167029 DT.120723333 DT.40255563 DT.97859001 DT.100746653 DT.101504 DT.100640494 DT.445991 DT.100021286 DT.100692682 DT.95167026 DT.100746652 DT.120723380 DT.422385 DT.92324626 DT.95167027 DT.100738161 DT.91716647 DT.97779648 DT.97859002 24/99 AceView cDNA sequences (see all 99): AI146564 AW070503 AW651739 BX402271 CR616862 CA441064 AY625000 AF220025 BM683037 AA463623 BC020770 AA861215 BX417025 AF220029 BM926476 BX335023 CA444489 NM_033034 CB111578 CB958623 BQ306461 AA298263 BM719062 AK027593
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM5 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | | | - | | | | | | | | | | | | - | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TRIM5
|
Expression
for TRIM5 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TRIM5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM5
SOURCE GeneReport for Unigene cluster: Hs.125300
SABiosciences Expression via Pathway-Focused PCR Arrays including TRIM5:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM5
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TRIM5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM5 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM5 |
Orthologs
for TRIM5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TRIM5 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TRIM586 |
-- |
30(a) |
1 → many |
GL343252.1(1250786-1269672) |
zebrafish
(Danio rerio) |
Actinopterygii |
trim476 |
tripartite motif containing 47 |
22(a) |
possible ortholog |
10(26752552-26762609) |
ENSEMBL Gene Tree for TRIM5 (if available)
TreeFam Gene Tree for TRIM5 (if available) |
Paralogs
for TRIM5 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM5 gene
- TRIM42 TRIM72 TRIM262 TRIM392 TRIM342 TRIML12 TRIM272 TRIM582
- TRIM682 TRIM102 TRIM152 TRIM602 TRIM222 TRIM172 TRIM62 TRIM6-TRIM342
- TRIM212 TRIM382 TRIM39-RPP212 TRIM112
18/61 SIMAP similar genes for TRIM5 using alignment to 17 protein entries: TRIM5_HUMAN (see all proteins)
(see all similar genes):FAM3A C12orf23 COQ5 pp12301 TRIM34 SH2B3
TRIM22 KIAA1651 TRIM6 TRIM6-TRIM34 TRIM36 DKFZp781D1977
GEMIN6 TRIM39 SNRPF TRIM21 TRIM60 TRIM68
TRIM5 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRIM5
PGOHUM00000258559
|
Genomic Variants
for TRIM5 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM5 (5684425 - 5934425 bp, first 250kb of TRIM5)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRIM5
1 CNV: 34458
1 Indel: 71262
Human Gene Mutation Database (HGMD): TRIM5
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM5 |
|
Disorders
/ Diseases
for TRIM5 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TRIM5 for disorders About GeneDecksing
OMIM gene information: 608487
OMIM disorders: --
7  diseases for TRIM5: About MalaCardshuman immunodeficiency virus infectious disease familial mediterranean fever hiv-1, resistance to rubella
migraine immunodeficiency leukemia
1 disease from the University of Copenhagen DISEASES database for TRIM5:Human immunodeficiency virus infectious disease 5 Novoseek disease relationships for TRIM5 gene About this table
Human Genome Epidemiology (HuGE) Navigator: TRIM5 (7 documents)
Export disorders for TRIM5 gene to outside databases
|
Publications
for TRIM5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM5 gene, integrated from 9 sources (see all 184):
(articles sorted by number of sources associating them with TRIM5) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The tripartite motif family identifies cell compartments. (PubMed id 11331580)1, 2, 3 Reymond A.... Ballabio A. (2001)
- p62/sequestosome-1 associates with and sustains the e xpression of retroviral restriction factor TRIM5alpha. (PubMed id 20357094)1, 2, 9 O'Connor C....Campbell E.M. (2010)
- Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription. (PubMed id 16474118)1, 2, 9 Passerini L.D.... Towers G.J. (2006)
- Trim5alpha protein restricts both HIV-1 and murine leukemia virus. (PubMed id 15249690)1, 2, 9 Yap M.W.... Stoye J.P. (2004)
- High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. (PubMed id 16401428)1, 2, 9 Sawyer S.L.... Malik H.S. (2006)
- TRIM5 structure, HIV-1 capsid recognition, and innate immune signaling. (PubMed id 22482711)1, 2 Grutter M.G. and Luban J. (2012)
- TRIM5alpha and species tropism of HIV/SIV. (PubMed id 22291694)1, 2 Nakayama E.E. and Shioda T. (2012)
- TRIM5 is an innate immune sensor for the retrovirus c apsid lattice. (PubMed id 21512573)1, 2 Pertel T....Luban J. (2011)
- Antiviral immunity: TRIM5 moonlights as a pattern recognition receptor. (PubMed id 21572451)1, 2 Jermy A. (2011)
- TRIM5 acts as more than a retroviral restriction facto r. (PubMed id 21866272)1, 2 de Silva S. and Wu L. (2011)
|
External Searches for TRIM5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM5 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM5 | Pharmacogenomics, SNPs, Pathways | | NIEHS-SNPs | http://egp.gs.washington.edu/data/trim5/ |
|
| | |
About This Section
| Patent Information for TRIM5 gene:
Search GeneIP for patents involving TRIM5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM5 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TRIM5 | | OriGene shRNA RFP for TRIM5 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM5 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM5 | | | OriGene Protein Over-expression Lysate for TRIM5 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM5 | | OriGene 3'-UTR Clone for TRIM5 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM5 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM5 | | OriGene Custom Protein Services for TRIM5 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM5 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM5 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM5 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM5 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM5 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM5 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TRIM5 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TRIM5 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM5 |
|  |  |  |  | | | | ThermoFisher Antibodies for TRIM5 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM5 |
| |  | |
|
|
|
GeneCards Homepage -
Last full update: 18 Mar 2013 -
Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013
View Random Gene
|
Category
|
|
|
von Willebrand factor
|
| GIFtS Group |
|
Developed at the Crown Human Genome Center,
Department of Molecular Genetics,
the Weizmann Institute of Science
Copyright © 1996-2013
, Weizmann Institute of Science. All Rights Reserved.
hostname: 356980-web2.xennexinc.com
index build: 106 solr: 1.4
|
