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Aliases for TRIM5 Gene

Aliases for TRIM5 Gene

  • Tripartite Motif Containing 5 2 3 5
  • RING-Type E3 Ubiquitin Transferase TRIM5 3 4
  • Tripartite Motif Protein TRIM5 2 3
  • RNF88 3 4
  • Tripartite Motif Containing 5 Transcript Variant Kappa 3
  • Tripartite Motif Containing 5 Transcript Variant Iota 3
  • Tripartite Motif-Containing Protein 5 3
  • Tripartite Motif Protein TRIM 2
  • Tripartite Motif-Containing 5 2
  • Ring Finger Protein 88 3
  • RING Finger Protein 88 4
  • EC 2.3.2.27 4
  • TRIM5alpha 3
  • EC 6.3.2 58

External Ids for TRIM5 Gene

Previous GeneCards Identifiers for TRIM5 Gene

  • GC11M006432
  • GC11M005986
  • GC11M005643
  • GC11M005649
  • GC11M005345

Summaries for TRIM5 Gene

Entrez Gene Summary for TRIM5 Gene

  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]

GeneCards Summary for TRIM5 Gene

TRIM5 (Tripartite Motif Containing 5) is a Protein Coding gene. Diseases associated with TRIM5 include Rubella and Human Immunodeficiency Virus Infectious Disease. Among its related pathways are Mesodermal Commitment Pathway and Interferon gamma signaling. GO annotations related to this gene include protein homodimerization activity and ligase activity. An important paralog of this gene is TRIM6-TRIM34.

UniProtKB/Swiss-Prot for TRIM5 Gene

  • Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Gene Wiki entry for TRIM5 Gene

Additional gene information for TRIM5 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM5 Gene

Genomics for TRIM5 Gene

Regulatory Elements for TRIM5 Gene

Enhancers for TRIM5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11H005618 1.3 Ensembl ENCODE dbSUPER 17.4 +318.3 318270 3 TFAP4 FOXA2 TAL1 SIN3A RARA ZNF7 TCF12 CTBP1 FOXK2 NCOR1 TRIM5 UBQLNL ENSG00000239920 HBG2 TRIM6 TRIM22 TRIM34
GH11H005683 1 ENCODE 13.4 +253.6 253582 2 FOXA2 ATF1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF766 CBX5 GATA2 TRIM22 TRIM5 HBG2 TRIM6 OR52D1 OR52N3P
GH11H005623 1.2 FANTOM5 ENCODE 9.8 +313.2 313184 3 HDAC1 TBP PKNOX1 TBL1XR1 SREBF2 SIN3A ZBTB40 RAD21 RFX5 YY1 TRIM5 TRIM34 TRIM22 OR51B2 OR56B4 OR56A1 OR56A3 OR52N4 OR51Q1 OR52E6
GH11H005808 1 Ensembl ENCODE 10.8 +129.6 129618 1 CTCF RB1 EBF1 RAD21 ZBTB48 SMC3 ZNF143 ZNF207 SMARCA5 ZNF654 OR52N3P TRIM5 TRIM22 TRIM6 OR52N1 OR52N2 OR52E6
GH11H005809 0.8 ENCODE 10.8 +128.2 128168 0 BCOR HDAC1 BRD4 LEF1 PKNOX1 ARNT NFRKB TAL1 CHAMP1 TCF12 OR52N3P TRIM5 TRIM22 TRIM6 OR52N2 OR52E6
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM5 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM5 Gene

Chromosome:
11
Start:
5,590,982 bp from pter
End:
5,938,619 bp from pter
Size:
347,638 bases
Orientation:
Minus strand

Genomic View for TRIM5 Gene

Genes around TRIM5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM5 Gene

Proteins for TRIM5 Gene

  • Protein details for TRIM5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C035-TRIM5_HUMAN
    Recommended name:
    Tripartite motif-containing protein 5
    Protein Accession:
    Q9C035
    Secondary Accessions:
    • A6NGQ1
    • A8WFA8
    • D3DQS8
    • D3DQS9
    • G3GJY1
    • Q2MLV4
    • Q2MLV8
    • Q2MLV9
    • Q2MLW1
    • Q2MLW3
    • Q2MLW4
    • Q2MLW6
    • Q2MLW7
    • Q2MLX1
    • Q2MLX2
    • Q2MLX3
    • Q2MLX5
    • Q2MLY3
    • Q2MLY4
    • Q2V6Q6
    • Q6GX26
    • Q8WU46
    • Q96SR5
    • Q9C031
    • Q9C032
    • Q9C033
    • Q9C034

    Protein attributes for TRIM5 Gene

    Size:
    493 amino acids
    Molecular mass:
    56338 Da
    Quaternary structure:
    • Can form homodimers and homotrimers. In addition to lower-order dimerization, also exhibits a higher-order multimerization and both low- and high-order multimerizations are essential for its restriction activity. Isoform Delta interacts with BTBD1 and BTBD2. Interacts with PSMC4, PSMC5, PSMD7 and HSPA8/HSC70 (By similarity). Interacts (via B30.2/SPRY domain) with HSPA1A/B. Interacts with PSMC2, MAP3K7/TAK1, TAB2 and TAB3 (PubMed:21512573, PubMed:22078707). Interacts with SQSTM1 (PubMed:20357094, PubMed:25127057). Interacts with TRIM6 and TRIM34 (PubMed:21680743, PubMed:17156811). Interacts with ULK1 (phosphorylated form), GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3C and BECN1 (PubMed:25127057).

    Three dimensional structures from OCA and Proteopedia for TRIM5 Gene

    Alternative splice isoforms for TRIM5 Gene

neXtProt entry for TRIM5 Gene

Selected DME Specific Peptides for TRIM5 Gene

Q9C035:
  • PLSLDCGHSFCQAC
  • TLKKPETF
  • RRVFRAP
  • KLQAALEM
  • CPICLEL
  • KEEVTCPICL
  • ICWLCERSQEHRGH
  • REEKASWK
  • PMTLCSP
  • KNQRRVFRA
  • MELLQGVDG
  • ADFEQLR
  • PQIIYGA
  • CARHGEKLLLFC
  • CPDRVGVF
  • ILDWEESNELQ
  • PNRHVANIVEKLREVKLSPE
  • HGEKLLLFCQED
  • ESNELQNLEKE
  • LEHRLQGS
  • PVFPYLNPRKC
  • EMVQQTQ
  • RVGVFLDYEA
  • VDGVIKR
  • NFNYCTG
  • AWILGVC
  • LKGMLEVFRELTDVRRYWVDVTVAPN
  • GFLIYKFS
  • YWVDVTVAPNNIS
  • SCPVCRISYQPENI
  • SITSGKHYWEVDV
  • MLRQKQQEAE
  • GYWVIGL
  • DYEACTVSFFN

Post-translational modifications for TRIM5 Gene

  • Autoubiquitinated in a RING finger- and UBE2D2-dependent manner. Monoubiquitinated by TRIM21. Deubiquitinated by Yersinia YopJ. Ubiquitination may not lead to proteasomal degradation.
  • Degraded in a proteasome-independent fashion in the absence of viral infection but in a proteasome-dependent fashion following exposure to restriction sensitive virus.
  • Ubiquitination at Lys50, Lys91, posLast=111111, Lys255, Lys282, Lys324, and Lys481
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for TRIM5 (TRIM5)
  • Cloud-Clone Corp. Antibodies for TRIM5
  • Santa Cruz Biotechnology (SCBT) Antibodies for TRIM5

Domains & Families for TRIM5 Gene

Gene Families for TRIM5 Gene

Graphical View of Domain Structure for InterPro Entry

Q9C035

UniProtKB/Swiss-Prot:

TRIM5_HUMAN :
  • The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (PubMed:22482711). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (By similarity).
  • Belongs to the TRIM/RBCC family.
Domain:
  • The B box-type zinc finger domain and the coiled-coil domain contribute to the higher and low order multimerization respectively which is essential for restriction activity (PubMed:22482711). The coiled coil domain is important for higher order multimerization by promoting the initial dimerization (By similarity).
  • The B30.2/SPRY domain acts as a capsid recognition domain. Polymorphisms in this domain explain the observed species-specific differences among orthologs (PubMed:22482711).
  • The RING-type zinc finger domain confers E3 ubiquitin ligase activity and is essential for retrovirus restriction activity, autoubiquitination and higher-order multimerization.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM5: view

Function for TRIM5 Gene

Molecular function for TRIM5 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.
UniProtKB/Swiss-Prot Function:
Capsid-specific restriction factor that prevents infection from non-host-adapted retroviruses. Blocks viral replication early in the life cycle, after viral entry but before reverse transcription. In addition to acting as a capsid-specific restriction factor, also acts as a pattern recognition receptor that activates innate immune signaling in response to the retroviral capsid lattice. Binding to the viral capsid triggers its E3 ubiquitin ligase activity, and in concert with the heterodimeric ubiquitin conjugating enzyme complex UBE2V1-UBE2N (also known as UBC13-UEV1A complex) generates Lys-63-linked polyubiquitin chains, which in turn are catalysts in the autophosphorylation of the MAP3K7/TAK1 complex (includes TAK1, TAB2, and TAB3). Activation of the MAP3K7/TAK1 complex by autophosphorylation results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes, thereby leading to an innate immune response in the infected cell. Restricts infection by N-tropic murine leukemia virus (N-MLV), equine infectious anemia virus (EIAV), simian immunodeficiency virus of macaques (SIVmac), feline immunodeficiency virus (FIV), and bovine immunodeficiency virus (BIV) (PubMed:17156811). Plays a role in regulating autophagy through activation of autophagy regulator BECN1 by causing its dissociation from its inhibitors BCL2 and TAB2 (PubMed:25127057). Also plays a role in autophagy by acting as a selective autophagy receptor which recognizes and targets HIV-1 capsid protein p24 for autophagic destruction (PubMed:25127057).

Enzyme Numbers (IUBMB) for TRIM5 Gene

Phenotypes From GWAS Catalog for TRIM5 Gene

Gene Ontology (GO) - Molecular Function for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004842 ubiquitin-protein transferase activity IDA,IEA 21512573
GO:0005515 protein binding IPI 20357094
GO:0008270 zinc ion binding IEA --
GO:0008329 signaling pattern recognition receptor activity IDA 21512573
GO:0016740 transferase activity IEA --
genes like me logo Genes that share ontologies with TRIM5: view
genes like me logo Genes that share phenotypes with TRIM5: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRIM5
  • Applied Biological Materials Clones for TRIM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM5 Gene

Localization for TRIM5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM5 Gene

Cytoplasm. Cytoplasm, P-body. Nucleus. Note=Predominantly cytoplasmic, and is only occasionally and partially localized in the nucleus (PubMed:25127057). Closely associates with proteasomal subunits in cytoplasmic bodies (By similarity). Colocalizes with SQSTM1 in cytoplasmic bodies (By similarity). {ECO:0000250 UniProtKB:Q0PF16, ECO:0000269 PubMed:25127057}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM5 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000932 P-body IDA 20357094
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,IDA 18248090
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with TRIM5: view

Pathways & Interactions for TRIM5 Gene

genes like me logo Genes that share pathways with TRIM5: view

Pathways by source for TRIM5 Gene

UniProtKB/Swiss-Prot Q9C035-TRIM5_HUMAN

  • Pathway: Protein modification; protein ubiquitination.

Gene Ontology (GO) - Biological Process for TRIM5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IDA 21512573
GO:0002221 pattern recognition receptor signaling pathway IEA --
GO:0002376 immune system process IEA --
GO:0006914 autophagy IDA,IEA 25127057
GO:0016032 viral process IEA --
genes like me logo Genes that share ontologies with TRIM5: view

No data available for SIGNOR curated interactions for TRIM5 Gene

Drugs & Compounds for TRIM5 Gene

(4) Drugs for TRIM5 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Adenosine monophosphate Approved Nutra 0
ATP Nutra Agonist 0

(2) Additional Compounds for TRIM5 Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
pyrophosphate
  • (4-)Diphosphoric acid ion
  • (P2O74-)Diphosphate
  • Diphosphate
  • Diphosphoric acid
  • PPi
14000-31-8
genes like me logo Genes that share compounds with TRIM5: view

Transcripts for TRIM5 Gene

Unigene Clusters for TRIM5 Gene

Tripartite motif containing 5:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for TRIM5
  • Applied Biological Materials Clones for TRIM5
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM5 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7 ^ 8 ^ 9
SP1: - -
SP2: - -
SP3:
SP4:

Relevant External Links for TRIM5 Gene

GeneLoc Exon Structure for
TRIM5
ECgene alternative splicing isoforms for
TRIM5

Expression for TRIM5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TRIM5 Gene

This gene is overexpressed in Adrenal (43.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TRIM5 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRIM5 Gene:

TRIM5

SOURCE GeneReport for Unigene cluster for TRIM5 Gene:

Hs.125300

Evidence on tissue expression from TISSUES for TRIM5 Gene

  • Liver(4.2)
  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TRIM5: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM5 Gene

Orthologs for TRIM5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM5 33 34
  • 99.05 (n)
cow
(Bos Taurus)
Mammalia LOC616948 33
  • 74.55 (n)
TRIM5 34
  • 59 (a)
OneToMany
-- 34
  • 58 (a)
OneToMany
-- 34
  • 56 (a)
OneToMany
-- 34
  • 50 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Trim5 33
  • 67.01 (n)
mouse
(Mus musculus)
Mammalia Trim5 33 16 34
  • 66.25 (n)
Trim12a 34
  • 53 (a)
OneToMany
Trim12c 34
  • 49 (a)
OneToMany
Trim30b 34
  • 47 (a)
OneToMany
Trim30a 34
  • 46 (a)
OneToMany
Trim30d 34
  • 45 (a)
OneToMany
Trim30c 34
  • 44 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TRIM34 34
  • 31 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 29 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 29 (a)
OneToMany
Species where no ortholog for TRIM5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TRIM5 Gene

ENSEMBL:
Gene Tree for TRIM5 (if available)
TreeFam:
Gene Tree for TRIM5 (if available)

Paralogs for TRIM5 Gene

genes like me logo Genes that share paralogs with TRIM5: view

Variants for TRIM5 Gene

Sequence variations from dbSNP and Humsavar for TRIM5 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs193920907 Uncertain significance 5,632,327(+) AAGCA(A/G)TGCAA intron-variant, reference, missense, utr-variant-5-prime
rs1000011327 -- 5,630,522(+) TATCA(G/T)CCACA intron-variant, upstream-variant-2KB
rs1000043628 -- 5,630,215(+) TAAAA(A/T)TAAAA intron-variant
rs1000045375 -- 5,613,101(+) ATGGA(C/T)TCAGG intron-variant, downstream-variant-500B
rs1000081513 -- 5,659,020(+) TGGGG(C/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM5 Gene

Variant ID Type Subtype PubMed ID
esv22319 CNV loss 19812545
esv3330343 CNV insertion 20981092
esv3625239 CNV loss 21293372
esv3625245 CNV loss 21293372
esv3625246 CNV loss 21293372
nsv1041568 CNV loss 25217958
nsv1046068 CNV gain 25217958
nsv1053414 CNV gain 25217958
nsv553241 CNV gain 21841781
nsv553273 CNV gain 21841781

Variation tolerance for TRIM5 Gene

Residual Variation Intolerance Score: 82.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.88; 94.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM5 Gene

Human Gene Mutation Database (HGMD)
TRIM5
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM5 Gene

Disorders for TRIM5 Gene

MalaCards: The human disease database

(2) MalaCards diseases for TRIM5 Gene - From: HGMD, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
rubella
  • german measles
human immunodeficiency virus infectious disease
- elite association - COSMIC cancer census association via MalaCards
Search TRIM5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TRIM5

Genetic Association Database (GAD)
TRIM5
Human Genome Epidemiology (HuGE) Navigator
TRIM5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM5
genes like me logo Genes that share disorders with TRIM5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TRIM5 Gene

Publications for TRIM5 Gene

  1. p62/sequestosome-1 associates with and sustains the expression of retroviral restriction factor TRIM5alpha. (PMID: 20357094) O'Connor C … Campbell EM (Journal of virology 2010) 3 4 22 60
  2. The effect of Trim5 polymorphisms on the clinical course of HIV-1 infection. (PMID: 18248091) van Manen D … Kootstra NA (PLoS pathogens 2008) 3 22 45 60
  3. Unique features of TRIM5alpha among closely related human TRIM family members. (PMID: 17156811) Li X … Sodroski J (Virology 2007) 3 4 22 60
  4. Retroviral restriction factors Fv1 and TRIM5alpha act independently and can compete for incoming virus before reverse transcription. (PMID: 16474118) Passerini LD … Towers GJ (Journal of virology 2006) 3 4 22 60
  5. High-frequency persistence of an impaired allele of the retroviral defense gene TRIM5alpha in humans. (PMID: 16401428) Sawyer SL … Malik HS (Current biology : CB 2006) 3 4 22 60

Products for TRIM5 Gene

  • Addgene plasmids for TRIM5

Sources for TRIM5 Gene

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