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Aliases for TRIM49C Gene

Aliases for TRIM49C Gene

  • Tripartite Motif Containing 49C 2 3 5
  • Tripartite Motif-Containing Protein 49-Like Protein 2 3 4
  • Tripartite Motif Containing 49-Like 2 2 3
  • TRIM49L2 3 4
  • Tripartite Motif-Containing Protein LOC642612 3
  • Tripartite Motif-Containing Protein 49C 3

External Ids for TRIM49C Gene

Previous HGNC Symbols for TRIM49C Gene

  • TRIM49L2

Previous GeneCards Identifiers for TRIM49C Gene

  • GC11P089768

Summaries for TRIM49C Gene

GeneCards Summary for TRIM49C Gene

TRIM49C (Tripartite Motif Containing 49C) is a Protein Coding gene. An important paralog of this gene is TRIM49.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49C Gene

Genomics for TRIM49C Gene

Regulatory Elements for TRIM49C Gene

Enhancers for TRIM49C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F090250 1 Ensembl ENCODE 5 +220.9 220863 0.4 ELF3 DRAP1 TBP SAP130 ARID4B DMAP1 MNT GABPA KAT8 RAD51 CHORDC1 TRIM49C DISC1FP1
GH11F090133 0.8 ENCODE 5.4 +104.5 104483 1.9 WRNIP1 THRB ZNF48 GLIS2 SP3 SP5 REST ZNF518A NR2F2 KAT8 NAALAD2 TRIM49C GC11P090149
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM49C on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM49C Gene

Chromosome:
11
Start:
90,030,149 bp from pter
End:
90,042,029 bp from pter
Size:
11,881 bases
Orientation:
Plus strand

Genomic View for TRIM49C Gene

Genes around TRIM49C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM49C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM49C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49C Gene

Proteins for TRIM49C Gene

  • Protein details for TRIM49C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CI26-TR49C_HUMAN
    Recommended name:
    Tripartite motif-containing protein 49C
    Protein Accession:
    P0CI26
    Secondary Accessions:
    • A0AVR7
    • A0AVR9
    • Q6DJV1
    • Q9NS80

    Protein attributes for TRIM49C Gene

    Size:
    452 amino acids
    Molecular mass:
    52933 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49C Gene

Post-translational modifications for TRIM49C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM49C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49C Gene

Domains & Families for TRIM49C Gene

Gene Families for TRIM49C Gene

Suggested Antigen Peptide Sequences for TRIM49C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CI26

UniProtKB/Swiss-Prot:

TR49C_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM49C: view

Function for TRIM49C Gene

Gene Ontology (GO) - Molecular Function for TRIM49C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM49C: view

Phenotypes for TRIM49C Gene

genes like me logo Genes that share phenotypes with TRIM49C: view

Animal Model Products

miRNA for TRIM49C Gene

miRTarBase miRNAs that target TRIM49C

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM49C Gene

Localization for TRIM49C Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM49C gene
Compartment Confidence
nucleus 2
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM49C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM49C: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM49C Gene

Pathways & Interactions for TRIM49C Gene

SuperPathways for TRIM49C Gene

No Data Available

Interacting Proteins for TRIM49C Gene

Gene Ontology (GO) - Biological Process for TRIM49C Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM49C Gene

Transcripts for TRIM49C Gene

mRNA/cDNA for TRIM49C Gene

(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49C Gene

No ASD Table

Relevant External Links for TRIM49C Gene

GeneLoc Exon Structure for
TRIM49C
ECgene alternative splicing isoforms for
TRIM49C

Expression for TRIM49C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TRIM49C Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49C Gene

This gene is overexpressed in Testis (x39.9) and Brain - Substantia nigra (x7.2).

NURSA nuclear receptor signaling pathways regulating expression of TRIM49C Gene:

TRIM49C

SOURCE GeneReport for Unigene cluster for TRIM49C Gene:

Hs.740080
genes like me logo Genes that share expression patterns with TRIM49C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TRIM49C Gene

Orthologs for TRIM49C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM48 34
  • 98.97 (n)
-- 35
  • 98 (a)
ManyToMany
-- 35
  • 98 (a)
ManyToMany
-- 35
  • 97 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia LOC485140 34
  • 64.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 33 (a)
ManyToMany
-- 35
  • 30 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 17 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 29 (a)
ManyToMany
-- 35
  • 28 (a)
ManyToMany
-- 35
  • 27 (a)
ManyToMany
-- 35
  • 24 (a)
ManyToMany
-- 35
  • 23 (a)
ManyToMany
-- 35
  • 21 (a)
ManyToMany
-- 35
  • 19 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 35
  • 20 (a)
ManyToMany
Species where no ortholog for TRIM49C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49C Gene

ENSEMBL:
Gene Tree for TRIM49C (if available)
TreeFam:
Gene Tree for TRIM49C (if available)

Paralogs for TRIM49C Gene

genes like me logo Genes that share paralogs with TRIM49C: view

Variants for TRIM49C Gene

Sequence variations from dbSNP and Humsavar for TRIM49C Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs111934996 -- 90,039,563(+) GGGAG(-/TC)TGCCA intron-variant
rs112051602 -- 90,032,795(+) AATAT(C/G)TAGTG intron-variant
rs112313451 -- 90,033,879(+) AGGCG(C/G)AGGTT intron-variant, upstream-variant-2KB
rs112983216 -- 90,037,163(+) AATTT(C/T)GAGTT intron-variant
rs113793081 -- 90,029,291(+) GGAGA(A/C/G)TGGAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM49C Gene

Variant ID Type Subtype PubMed ID
nsv983051 CNV duplication 23825009
nsv951055 CNV deletion 24416366
nsv832225 CNV gain 17160897
nsv7222 OTHER inversion 18451855
nsv508647 CNV deletion 20534489
nsv1070475 CNV deletion 25765185
nsv1036092 CNV loss 25217958
esv3892056 CNV gain+loss 25118596
esv3579993 CNV gain 25503493
esv2759849 CNV gain+loss 17122850
dgv407e212 CNV loss 25503493

Variation tolerance for TRIM49C Gene

Gene Damage Index Score: 1.62; 31.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM49C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM49C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM49C Gene

Disorders for TRIM49C Gene

Relevant External Links for TRIM49C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM49C

No disorders were found for TRIM49C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM49C Gene

Publications for TRIM49C Gene

  1. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 3 4 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K. … Sawyer S.L. (PLoS Genet. 2011) 3 64
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 64
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TRIM49C Gene

Sources for TRIM49C Gene

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