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Aliases for TRIM49B Gene

Aliases for TRIM49B Gene

  • Tripartite Motif Containing 49B 2 3
  • RING Finger Protein 18B 4
  • RNF18B 4

External Ids for TRIM49B Gene

Previous GeneCards Identifiers for TRIM49B Gene

  • GC11M049813
  • GC11M049855

Summaries for TRIM49B Gene

GeneCards Summary for TRIM49B Gene

TRIM49B (Tripartite Motif Containing 49B) is a Protein Coding gene. An important paralog of this gene is TRIM77.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49B Gene

Genomics for TRIM49B Gene

Genomic Location for TRIM49B Gene

49,027,501 bp from pter
49,038,451 bp from pter
10,951 bases
Plus strand

Genomic View for TRIM49B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TRIM49B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49B Gene

Proteins for TRIM49B Gene

  • Protein details for TRIM49B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative tripartite motif-containing protein 49B
    Protein Accession:
    Secondary Accessions:

    Protein attributes for TRIM49B Gene

    452 amino acids
    Molecular mass:
    52747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49B Gene

Proteomics data for TRIM49B Gene at MOPED

Post-translational modifications for TRIM49B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM49B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49B Gene

Domains for TRIM49B Gene

Gene Families for TRIM49B Gene

  • RNF :RING-type (C3HC4) zinc fingers
  • TRIM :Tripartite motif containing / Tripartite motif containing

Protein Domains for TRIM49B Gene

Suggested Antigen Peptide Sequences for TRIM49B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • A6NDI0
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM49B: view

Function for TRIM49B Gene

Gene Ontology (GO) - Molecular Function for TRIM49B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding --
genes like me logo Genes that share ontologies with TRIM49B: view

Phenotypes for TRIM49B Gene

GenomeRNAi human phenotypes for TRIM49B:
genes like me logo Genes that share phenotypes with TRIM49B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TRIM49B Gene

Localization for TRIM49B Gene

Subcellular locations from

Jensen Localization Image for TRIM49B Gene COMPARTMENTS Subcellular localization image for TRIM49B gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TRIM49B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular --
genes like me logo Genes that share ontologies with TRIM49B: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM49B Gene

Pathways for TRIM49B Gene

SuperPathways for TRIM49B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM49B Gene


No data available for Pathways by source for TRIM49B Gene

Transcripts for TRIM49B Gene

mRNA/cDNA for TRIM49B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM49B Gene

Tripartite motif containing 49B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TRIM49B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49B Gene

No ASD Table

Relevant External Links for TRIM49B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM49B Gene

mRNA expression in normal human tissues for TRIM49B Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49B Gene

This gene is overexpressed in Testis (13.6), Brain - Substantia nigra (7.8), and Brain - Hypothalamus (7.2).

SOURCE GeneReport for Unigene cluster for TRIM49B Gene Hs.448644

genes like me logo Genes that share expressions with TRIM49B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein expression and mRNA Expression by UniProt/SwissProt for TRIM49B Gene

Orthologs for TRIM49B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM49B 35
  • 99.12 (n)
  • 97.35 (a)
TRIM49B 36
  • 97 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 21 (a)
-- 36
  • 27 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 26 (a)
-- 36
  • 24 (a)
-- 36
  • 30 (a)
-- 36
  • 30 (a)
-- 36
  • 27 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 16 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
-- 36
  • 30 (a)
-- 36
  • 19 (a)
-- 36
  • 21 (a)
-- 36
  • 23 (a)
-- 36
  • 23 (a)
-- 36
  • 27 (a)
(Danio rerio)
Actinopterygii trim109 36
  • 20 (a)
Species with no ortholog for TRIM49B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49B Gene

Gene Tree for TRIM49B (if available)
Gene Tree for TRIM49B (if available)

Paralogs for TRIM49B Gene

Selected SIMAP similar genes for TRIM49B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM49B: view

Variants for TRIM49B Gene

Sequence variations from dbSNP and Humsavar for TRIM49B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs2696913 -- 49,038,358(-) TATCA(C/T)TGAGA downstream-variant-500B
rs2696914 - 49,037,810(-) CAGCA(G/T)AAGTG missense, reference
rs2696915 -- 49,037,319(-) AAACA(A/G)AACCC intron-variant
rs2696916 -- 49,036,561(-) AATCT(A/G)ACTGT intron-variant
rs2696917 -- 49,035,844(-) TTTTC(A/C/G)ATCTA intron-variant

Relevant External Links for TRIM49B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TRIM49B Gene

Disorders for TRIM49B Gene

No disorders were found for TRIM49B Gene.

No data available for UniProtKB/Swiss-Prot for TRIM49B Gene

Publications for TRIM49B Gene

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K. … Sawyer S.L. (PLoS Genet. 2011) 3 4
  2. Human chromosome 11 DNA sequence and analysis including novel gene identification. (PMID: 16554811) Taylor T.D. … Sakaki Y. (Nature 2006) 4
  3. TLR8-dependent TNF-(alpha) overexpression in Fanconi anemia group C cells. (PMID: 19850743) Vanderwerf S.M. … Bagby G.C. (Blood 2009) 3

Products for TRIM49B Gene

Sources for TRIM49B Gene

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