Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM49B Gene

Aliases for TRIM49B Gene

  • Tripartite Motif Containing 49B 2 3 5
  • RING Finger Protein 18B 4
  • RNF18B 4

External Ids for TRIM49B Gene

Previous GeneCards Identifiers for TRIM49B Gene

  • GC11M049813
  • GC11M049855

Summaries for TRIM49B Gene

GeneCards Summary for TRIM49B Gene

TRIM49B (Tripartite Motif Containing 49B) is a Protein Coding gene. An important paralog of this gene is TRIM64C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49B Gene

Genomics for TRIM49B Gene

Regulatory Elements for TRIM49B Gene

Enhancers for TRIM49B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM49B on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM49B Gene

Chromosome:
11
Start:
49,027,501 bp from pter
End:
49,038,451 bp from pter
Size:
10,951 bases
Orientation:
Plus strand

Genomic View for TRIM49B Gene

Genes around TRIM49B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM49B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM49B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49B Gene

Proteins for TRIM49B Gene

  • Protein details for TRIM49B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NDI0-TR49B_HUMAN
    Recommended name:
    Putative tripartite motif-containing protein 49B
    Protein Accession:
    A6NDI0

    Protein attributes for TRIM49B Gene

    Size:
    452 amino acids
    Molecular mass:
    52747 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49B Gene

Proteomics data for TRIM49B Gene at MOPED

Post-translational modifications for TRIM49B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM49B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49B Gene

Domains & Families for TRIM49B Gene

Gene Families for TRIM49B Gene

Protein Domains for TRIM49B Gene

Suggested Antigen Peptide Sequences for TRIM49B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NDI0

UniProtKB/Swiss-Prot:

TR49B_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM49B: view

Function for TRIM49B Gene

Phenotypes for TRIM49B Gene

GenomeRNAi human phenotypes for TRIM49B:
genes like me logo Genes that share phenotypes with TRIM49B: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM49B Gene

Localization for TRIM49B Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM49B Gene COMPARTMENTS Subcellular localization image for TRIM49B gene
Compartment Confidence
nucleus 2
cytoskeleton 1
cytosol 1
extracellular 1
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM49B Gene

Pathways & Interactions for TRIM49B Gene

SuperPathways for TRIM49B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM49B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TRIM49B Gene

Drugs & Compounds for TRIM49B Gene

No Compound Related Data Available

Transcripts for TRIM49B Gene

mRNA/cDNA for TRIM49B Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM49B Gene

Tripartite motif containing 49B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49B Gene

No ASD Table

Relevant External Links for TRIM49B Gene

GeneLoc Exon Structure for
TRIM49B
ECgene alternative splicing isoforms for
TRIM49B

Expression for TRIM49B Gene

mRNA expression in normal human tissues for TRIM49B Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49B Gene

This gene is overexpressed in Testis (x13.6), Brain - Substantia nigra (x7.8), and Brain - Hypothalamus (x7.2).

SOURCE GeneReport for Unigene cluster for TRIM49B Gene Hs.448644

genes like me logo Genes that share expression patterns with TRIM49B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM49B Gene

Orthologs for TRIM49B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM49B 35
  • 99.12 (n)
  • 97.35 (a)
TRIM49B 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 29 (a)
ManyToMany
-- 36
  • 26 (a)
ManyToMany
-- 36
  • 24 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 16 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 19 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 23 (a)
ManyToMany
-- 36
  • 27 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 36
  • 20 (a)
ManyToMany
Species with no ortholog for TRIM49B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49B Gene

ENSEMBL:
Gene Tree for TRIM49B (if available)
TreeFam:
Gene Tree for TRIM49B (if available)

Paralogs for TRIM49B Gene

(18) SIMAP similar genes for TRIM49B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TRIM49B: view

Variants for TRIM49B Gene

Sequence variations from dbSNP and Humsavar for TRIM49B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2696914 - 49,037,810(-) CAGCA(G/T)AAGTG reference, missense
rs7114969 -- 49,035,845(+) AGATC(A/G)AAAAA intron-variant
rs7118470 -- 49,036,287(+) TGCAG(A/G)TTTTT intron-variant
rs7118782 -- 49,036,721(+) ATACA(A/G)AATTG intron-variant
rs7122058 -- 49,037,017(+) TGGTC(A/G)AAGAT intron-variant

Variation tolerance for TRIM49B Gene

Residual Variation Intolerance Score: 87.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.73; 32.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TRIM49B Gene

Disorders for TRIM49B Gene

Relevant External Links for TRIM49B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM49B

No disorders were found for TRIM49B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM49B Gene

Publications for TRIM49B Gene

  1. Identification of a genomic reservoir for new TRIM genes in primate genomes. (PMID: 22144910) Han K. … Sawyer S.L. (PLoS Genet. 2011) 3 4 67

Products for TRIM49B Gene

Sources for TRIM49B Gene

Content