TRIM49 Gene
protein-coding GIFtS: 43
GCID: GC11M089530
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tripartite motif containing 49(Previous names: ring finger protein 18, tripartite motif-containing 49...)
(Previous symbol: RNF18)
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Aliases
for TRIM49 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 491 2 | | Testis-Specific RING-Finger Protein2 3 | | RNF181 2 3 5 | | TRIM49L22 | | RING Finger Protein 181 2 3 | | Testis-Specific RING Finger Protein2 | | TRIM49A1 2 | | Tripartite Motif-Containing Protein 492 | | Tripartite Motif-Containing 491 2 | | |
Export aliases for TRIM49 gene to outside databasesPrevious GC identifers: GC11M089171 GC11M085755 |
Summaries
for TRIM49 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TRIM49:
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-proteininteractions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and geneduplicates have also been identified on chromosome 11. (provided by RefSeq, Aug 2010)
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Genomic Views
for TRIM49 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NC_018922.1 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM49 gene promoter:
IRF-2 NCX/Ncx IRF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM49
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM49 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11p11.12-q12 Ensembl cytogenetic band: 11q14.3 HGNC cytogenetic band: 11p11.12-q12TRIM49 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11M089530: view genomic region
(about GC identifiers)
Start:
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89,530,823 bp from pter |
End:
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89,541,743 bp from pter |
Size:
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10,921 bases |
Orientation:
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minus strand |
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Proteins
for TRIM49 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI49_HUMAN, P0CI25 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 49 Size: 452 amino acids; 52888 Da
Secondary accessions: A0AVR7 A0AVR9 Q6DJV1 Q9NS80Explore the universe of human proteins at neXtProt for TRIM49: NX_P0CI25
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P0CI25
TRIM49 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_065091.1
ENSEMBL proteins: ENSP00000327604 ENSP00000431618
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM49 for ontologies About GeneDecksing
TRIM49 Antibody Products:
Assay Products for TRIM49: |
Protein
Domains /
Families
for TRIM49 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM49 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry P0CI25ProtoNet protein and cluster: P0CI25 UniProtKB/Swiss-Prot: TRI49_HUMAN, P0CI25Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 B30.2/SPRY domainSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM49 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM49 (NM_020358) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM49 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM49 for ontologies About GeneDecksing
2 GenomeRNAi human phenotypes for TRIM49:
|
Pathways & Interactions
for TRIM49 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM49
|
Drugs & Compounds
for TRIM49 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM49
Search CenterWatch for drugs/clinical trials and news about TRIM49 / TRI49
|
Transcripts
for TRIM49 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM49 gene: NM_020358.2 Unigene Cluster for TRIM49: Tripartite motif containing 49 Hs.534218 Unigene Representative Sequence: NM_0203582 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000329758(uc001pdb.3) ENST00000532501
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM49 (NM_020358) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM49 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM49 |
Additional cDNA sequence: AB037682.1 BC075019.2 BC075020.2 BC126472.1 JF968461.1 1 DOTS entry: DT.91741373 4 AceView cDNA sequences: BV195728 BC075019 BC075020 BV199056
GeneLoc Exon Structure
|
Expression
for TRIM49 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM49 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTGAATGAA
About this image
See TRIM49 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM49
SOURCE GeneReport for Unigene cluster: Hs.534218
UniProtKB/Swiss-Prot: TRI49_HUMAN, P0CI25Tissue specificity: Preferentially expressed in testis
SABiosciences Custom PCR Arrays for TRIM49
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM49
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM49 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM49 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM49 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM49 |
Orthologs
for TRIM49 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TRIM49 (if available)
TreeFam Gene Tree for TRIM49 (if available) |
Paralogs
for TRIM49 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM49 gene
- TRIM49C1 2 TRIM64B2 TRIM432 TRIM49B2 TRIM512 TRIM64C2 TRIM482
18/24 SIMAP similar genes for TRIM49 using alignment to 2 protein entries: TRI49_HUMAN (see all proteins)
(see all similar genes):TRIM49B TRIM49C TRIM49D2P TRIM51 TRIM48 TRIM41
TRIM43 TRIM43B MEFV TRIM60 TRIM61 TRIM64
TRIM64B TRIM64C TRIM39 TRIM22 TRIM27 TRIML1
TRIM49 for paralogs About GeneDecksing
1 Pseudogenes.org Pseudogene for TRIM49
PGOHUM00000258095
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Genomic Variants
for TRIM49 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM49 (89530823 - 89541743 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TRIM49
2 CNVs: 2943 3862 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM49 |
|
Disorders
/ Diseases
for TRIM49 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TRIM49 for disorders About MalaCards
TRIM49 for disorders About GeneDecksing
OMIM gene information: 606124
OMIM disorders: --
Export disorders for TRIM49 gene to outside databases
|
Publications
for TRIM49 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM49 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM49) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach. (PubMed id 11018261)1, 2, 3 Yoshikawa T....Saito T. (2000)
- Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)1, 2 Taylor T.D....Sakaki Y. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification of a genomic reservoir for new TRIM genes in primate genomes. (PubMed id 22144910)1 Han K.... Sawyer S.L. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TRIM49 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TRIM49 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM49 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM49 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for TRIM49 gene:
Search GeneIP for patents involving TRIM49
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM49 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM49 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM49 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM49 | | | OriGene Protein Over-expression Lysate for TRIM49 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM49 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM49 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM49 |
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| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM49 |
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