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Aliases for TRIM49 Gene

Aliases for TRIM49 Gene

  • Tripartite Motif Containing 49 2 3 5
  • Tripartite Motif-Containing 49 2 3
  • Ring Finger Protein 18 2 3
  • RNF18 3 4
  • Testis-Specific RING Finger Protein 3
  • Testis-Specific Ring-Finger Protein 3
  • Testis-Specific RING-Finger Protein 4
  • RING Finger Protein 18 4
  • TRIM49L2 3
  • TRIM49A 3

External Ids for TRIM49 Gene

Previous HGNC Symbols for TRIM49 Gene

  • RNF18

Previous GeneCards Identifiers for TRIM49 Gene

  • GC11M089171
  • GC11M089530
  • GC11M085755

Summaries for TRIM49 Gene

Entrez Gene Summary for TRIM49 Gene

  • The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This gene has been found to be preferentially expressed in testis. Related pseudogenes and gene duplicates have also been identified on chromosome 11. [provided by RefSeq, Aug 2010]

GeneCards Summary for TRIM49 Gene

TRIM49 (Tripartite Motif Containing 49) is a Protein Coding gene. An important paralog of this gene is TRIM64C.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM49 Gene

Genomics for TRIM49 Gene

Regulatory Elements for TRIM49 Gene

Enhancers for TRIM49 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM49 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM49 Gene

89,797,655 bp from pter
89,808,575 bp from pter
10,921 bases
Minus strand

Genomic View for TRIM49 Gene

Genes around TRIM49 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM49 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM49 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM49 Gene

Proteins for TRIM49 Gene

  • Protein details for TRIM49 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 49
    Protein Accession:
    Secondary Accessions:
    • A0AVR7
    • A0AVR9
    • Q6DJV1
    • Q9NS80

    Protein attributes for TRIM49 Gene

    452 amino acids
    Molecular mass:
    52888 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TRIM49 Gene

Proteomics data for TRIM49 Gene at MOPED

Post-translational modifications for TRIM49 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM49 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM49 Gene

Domains & Families for TRIM49 Gene

Gene Families for TRIM49 Gene

Protein Domains for TRIM49 Gene

Suggested Antigen Peptide Sequences for TRIM49 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM49: view

Function for TRIM49 Gene

Gene Ontology (GO) - Molecular Function for TRIM49 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25127057
GO:0019901 protein kinase binding IPI 25127057
genes like me logo Genes that share ontologies with TRIM49: view
genes like me logo Genes that share phenotypes with TRIM49: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM49 Gene

Localization for TRIM49 Gene

Subcellular locations from

Jensen Localization Image for TRIM49 Gene COMPARTMENTS Subcellular localization image for TRIM49 gene
Compartment Confidence
cytosol 2
nucleus 2
mitochondrion 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM49 Gene

Pathways & Interactions for TRIM49 Gene

SuperPathways for TRIM49 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TRIM49 Gene


No data available for Pathways by source and SIGNOR curated interactions for TRIM49 Gene

Drugs & Compounds for TRIM49 Gene

No Compound Related Data Available

Transcripts for TRIM49 Gene

mRNA/cDNA for TRIM49 Gene

(1) REFSEQ mRNAs :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM49 Gene

No ASD Table

Relevant External Links for TRIM49 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM49 Gene

mRNA expression in normal human tissues for TRIM49 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM49 Gene

This gene is overexpressed in Testis (x27.1) and Brain - Substantia nigra (x6.9).

SOURCE GeneReport for Unigene cluster for TRIM49 Gene Hs.534218

mRNA Expression by UniProt/SwissProt for TRIM49 Gene

Tissue specificity: Preferentially expressed in testis.
genes like me logo Genes that share expression patterns with TRIM49: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TRIM49 Gene

Orthologs for TRIM49 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM49 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia LOC485140 35
  • 63.84 (n)
  • 50 (a)
-- 36
  • 49 (a)
(Pan troglodytes)
Mammalia TRIM48 35
  • 98.89 (n)
  • 97.57 (a)
-- 36
  • 97 (a)
-- 36
  • 97 (a)
-- 36
  • 98 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 33 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 21 (a)
-- 36
  • 28 (a)
-- 36
  • 28 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 26 (a)
-- 36
  • 24 (a)
-- 36
  • 29 (a)
-- 36
  • 29 (a)
-- 36
  • 28 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 17 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 27 (a)
-- 36
  • 29 (a)
-- 36
  • 19 (a)
-- 36
  • 21 (a)
-- 36
  • 23 (a)
-- 36
  • 24 (a)
-- 36
  • 28 (a)
(Danio rerio)
Actinopterygii FP015862.1 36
  • 17 (a)
Species with no ortholog for TRIM49:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM49 Gene

Gene Tree for TRIM49 (if available)
Gene Tree for TRIM49 (if available)

Paralogs for TRIM49 Gene Pseudogenes for TRIM49 Gene

genes like me logo Genes that share paralogs with TRIM49: view

Variants for TRIM49 Gene

Sequence variations from dbSNP and Humsavar for TRIM49 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs12417980 - 89,798,372(+) CTTTC(C/T)ATCTA reference, missense
rs537176 -- 89,807,016(-) TATCT(G/T)AAATC intron-variant
rs542935 -- 89,808,025(+) GTTAT(G/T)ATTTT intron-variant
rs548763 -- 89,802,883(-) CAAAT(G/T)GTCAA intron-variant
rs560294 -- 89,800,154(-) CCCCA(A/G)AACCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM49 Gene

Variant ID Type Subtype PubMed ID
nsv898094 CNV Gain 21882294
dgv412e1 CNV Complex 17122850
nsv508644 CNV Loss 20534489
nsv426 CNV Insertion 18451855
nsv826025 CNV Gain 20364138
dgv233n67 CNV Gain 20364138
dgv1256n71 CNV Loss 21882294
dgv1257n71 CNV Loss 21882294
nsv832225 CNV Gain 17160897

Variation tolerance for TRIM49 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.74; 66.41% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TRIM49 Gene

Disorders for TRIM49 Gene

Relevant External Links for TRIM49

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM49 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM49 Gene

Publications for TRIM49 Gene

  1. Isolation of a cDNA for a novel human RING finger protein gene, RNF18, by the virtual transcribed sequence (VTS) approach. (PMID: 11018261) Yoshikawa T. … Saito T. (Biochim. Biophys. Acta 2000) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TRIM proteins regulate autophagy and can target autophagic substrates by direct recognition. (PMID: 25127057) Mandell M.A. … Deretic V. (Dev. Cell 2014) 3
  4. Ubiquitin-dependent recruitment of the Bloom syndrome helicase upon replication stress is required to suppress homologous recombination. (PMID: 23708797) Tikoo S. … Sengupta S. (EMBO J. 2013) 3
  5. Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition. (PMID: 22939624) Taipale M. … Lindquist S. (Cell 2012) 3

Products for TRIM49 Gene

Sources for TRIM49 Gene