TRIM48 Gene
protein-coding GIFtS: 39
GCID: GC11P055029
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tripartite motif containing 48(Previous name: tripartite motif-containing 48 )
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Aliases
for TRIM48 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Tripartite Motif Containing 481 2 | | RNF1011 2 3 | | Tripartite Motif-Containing 481 2 | | RING Finger Protein 1012 3 | | Tripartite Motif-Containing Protein 482 |
Export aliases for TRIM48 gene to outside databasesPrevious GC identifers: GC11P056542 GC11P055278 GC11P054805 GC11P054786 GC11P051358 |
Summaries
for TRIM48 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TRIM48 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000011.9 NT_167190.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TRIM48 gene promoter:
NCX/Ncx
Other transcription factors
Search SABiosciences Chromatin IP Primers for TRIM48
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM48 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 11q11 Ensembl cytogenetic band: 11q11 HGNC cytogenetic band: 11q12TRIM48 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 11 GeneLoc Exon Structure GeneLoc location for GC11P055029: view genomic region
(about GC identifiers)
Start:
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55,029,658 bp from pter |
End:
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55,038,595 bp from pter |
Size:
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8,938 bases |
Orientation:
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plus strand |
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Proteins
for TRIM48 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TRI48_HUMAN, Q8IWZ4 (See
protein sequence)Recommended Name: Tripartite motif-containing protein 48 Size: 208 amino acids; 24498 Da
Sequence caution: Sequence=AAO14946.1; Type=Erroneous termination; Positions=209; Note=Translated as stop;
Secondary accessions: Q9BUW4Explore the universe of human proteins at neXtProt for TRIM48: NX_Q8IWZ4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IWZ4
TRIM48 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_077019.2
ENSEMBL proteins: ENSP00000402414
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005622 | intracellular |
IEA | -- |
TRIM48 for ontologies About GeneDecksing
TRIM48 Antibody Products:
Assay Products for TRIM48: |
Protein
Domains /
Families
for TRIM48 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TRIM48 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8IWZ4ProtoNet protein and cluster: Q8IWZ4 3 Blocks protein families: IPB000315 B-box zinc finger signature IPB001841 Zn-finger IPB003879 Butyrophylin C-terminal DUF signature
UniProtKB/Swiss-Prot: TRI48_HUMAN, Q8IWZ4Similarity: Belongs to the TRIM/RBCC familySimilarity: Contains 1 B box-type zinc fingerSimilarity: Contains 1 RING-type zinc finger |
Function
for TRIM48 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TRIM48 (NM_024114) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM48 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM48 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008270 | zinc ion binding |
IEA | -- |
TRIM48 for ontologies About GeneDecksing
|
Pathways & Interactions
for TRIM48 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TRIM48
|
Drugs & Compounds
for TRIM48 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TRIM48
Search CenterWatch for drugs/clinical trials and news about TRIM48 / TRI48
|
Transcripts
for TRIM48 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TRIM48 gene: NM_024114.3 Unigene Cluster for TRIM48: Tripartite motif containing 48 Hs.195715 [show with all ESTs]Unigene Representative Sequence: AF5218691 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000417545(uc010rid.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TRIM48 (NM_024114) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TRIM48 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM48 |
Additional cDNA sequence: AF521869.1 BC001862.2 1 DOTS entry: DT.70101068 14 AceView cDNA sequences: M85802 BE727349 AF521869 BF025698 BE389590 BE275390 BC001862 BE893553 NM_024114 BU154755 BI093942 BG335390 BG475587 BF125311
GeneLoc Exon Structure
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Expression
for TRIM48 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TRIM48 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGAATTATT
About this image
See TRIM48 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TRIM48
SOURCE GeneReport for Unigene cluster: Hs.195715
SABiosciences Expression via Pathway-Focused PCR Array including TRIM48: | Ubiquitin Ligases in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM48
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TRIM48 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM48 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM48 |
Orthologs
for TRIM48 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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ENSEMBL Gene Tree for TRIM48 (if available)
TreeFam Gene Tree for TRIM48 (if available) |
Paralogs
for TRIM48 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TRIM48 gene
- TRIM64B2 TRIM432 TRIM492 TRIM49B2 TRIM49C2 TRIM512 TRIM64C2
18/23 SIMAP similar genes for TRIM48 using alignment to 1 protein entry: TRI48_HUMAN(see all similar genes):TRIM51 TRIM49 TRIM49C TRIM49D2P TRIM64B TRIM64
TRIM64C TRIM49B TRIM22 TRIM27 TRIM21 TRIM26
TRIM75 TRIM34 TRIM60 TRIM61 TRIM39 TRIM68
TRIM48 for paralogs About GeneDecksing
5 Pseudogenes.org Pseudogenes for TRIM48
PGOHUM00000257810 PGOHUM00000257817 PGOHUM00000240217 PGOHUM00000258143 PGOHUM00000259791
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Genomic Variants
for TRIM48 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 11 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TRIM48 (55029658 - 55038595 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TRIM48
6 CNVs: 61150 34976 38025 65954 65953 8690 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM48 |
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Disorders
/ Diseases
for TRIM48 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TRIM48 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TRIM48 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TRIM48) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
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External Searches for TRIM48 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TRIM48 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TRIM48 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TRIM48 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TRIM48 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TRIM48 gene:
Search GeneIP for patents involving TRIM48
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TRIM48 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
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| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TRIM48 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TRIM48 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TRIM48 | | | OriGene Protein Over-expression Lysate for TRIM48 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TRIM48 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TRIM48 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TRIM48 | | OriGene Custom Protein Services for TRIM48 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TRIM48 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TRIM48 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TRIM48 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TRIM48 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TRIM48 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TRIM48 |
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| | | | Search Tocris compounds for TRIM48 |
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 | | | TRIM48 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for TRIM48 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM48 |
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