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Aliases for TRIM48 Gene

Aliases for TRIM48 Gene

  • Tripartite Motif Containing 48 2 3 5
  • RING Finger Protein 101 3 4
  • RNF101 3 4
  • Tripartite Motif-Containing Protein 48 3
  • Tripartite Motif-Containing 48 2

External Ids for TRIM48 Gene

Previous GeneCards Identifiers for TRIM48 Gene

  • GC11P056542
  • GC11P055278
  • GC11P054805
  • GC11P054786
  • GC11P055029
  • GC11P051358

Summaries for TRIM48 Gene

GeneCards Summary for TRIM48 Gene

TRIM48 (Tripartite Motif Containing 48) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TRIM49D1.

Additional gene information for TRIM48 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM48 Gene

Genomics for TRIM48 Gene

GeneHancer (GH) Regulatory Elements for TRIM48 Gene

Promoters and enhancers for TRIM48 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I055262 Promoter 0.5 EPDnew 550.8 0.0 -46 0.1 TRIM48 GC11P055219
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM48 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM48 gene promoter:

Genomic Locations for TRIM48 Gene

Genomic Locations for TRIM48 Gene
chr11:55,262,182-55,271,119
(GRCh38/hg38)
Size:
8,938 bases
Orientation:
Plus strand
chr11:55,029,658-55,038,595
(GRCh37/hg19)

Genomic View for TRIM48 Gene

Genes around TRIM48 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM48 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM48 Gene

Proteins for TRIM48 Gene

  • Protein details for TRIM48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWZ4-TRI48_HUMAN
    Recommended name:
    Tripartite motif-containing protein 48
    Protein Accession:
    Q8IWZ4
    Secondary Accessions:
    • Q9BUW4

    Protein attributes for TRIM48 Gene

    Size:
    208 amino acids
    Molecular mass:
    24498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO14946.1; Type=Erroneous termination; Positions=209; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for TRIM48 Gene

Post-translational modifications for TRIM48 Gene

No Post-translational modifications

Other Protein References for TRIM48 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM48 Gene

Domains & Families for TRIM48 Gene

Gene Families for TRIM48 Gene

Suggested Antigen Peptide Sequences for TRIM48 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWZ4

UniProtKB/Swiss-Prot:

TRI48_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM48: view

Function for TRIM48 Gene

Gene Ontology (GO) - Molecular Function for TRIM48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM48: view
genes like me logo Genes that share phenotypes with TRIM48: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM48 Gene

Localization for TRIM48 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM48 gene
Compartment Confidence
extracellular 2
nucleus 2
plasma membrane 1
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for TRIM48 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM48: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for TRIM48 Gene

Pathways & Interactions for TRIM48 Gene

genes like me logo Genes that share pathways with TRIM48: view

Pathways by source for TRIM48 Gene

Interacting Proteins for TRIM48 Gene

Gene Ontology (GO) - Biological Process for TRIM48 Gene

None

No data available for SIGNOR curated interactions for TRIM48 Gene

Drugs & Compounds for TRIM48 Gene

No Compound Related Data Available

Transcripts for TRIM48 Gene

mRNA/cDNA for TRIM48 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM48 Gene

Tripartite motif containing 48:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM48 Gene

No ASD Table

Relevant External Links for TRIM48 Gene

GeneLoc Exon Structure for
TRIM48
ECgene alternative splicing isoforms for
TRIM48

Expression for TRIM48 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM48 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM48 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x39.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM48 Gene



NURSA nuclear receptor signaling pathways regulating expression of TRIM48 Gene:

TRIM48

SOURCE GeneReport for Unigene cluster for TRIM48 Gene:

Hs.195715
genes like me logo Genes that share expression patterns with TRIM48: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM48 Gene

Orthologs for TRIM48 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM48 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM48 34
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 25 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
-- 34
  • 16 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 34
  • 24 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 14 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 30 (a)
ManyToMany
-- 34
  • 28 (a)
ManyToMany
-- 34
  • 22 (a)
ManyToMany
-- 34
  • 21 (a)
ManyToMany
-- 34
  • 17 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 15 (a)
ManyToMany
-- 34
  • 14 (a)
ManyToMany
-- 34
  • 13 (a)
ManyToMany
-- 34
  • 11 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 34
  • 10 (a)
ManyToMany
Species where no ortholog for TRIM48 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM48 Gene

ENSEMBL:
Gene Tree for TRIM48 (if available)
TreeFam:
Gene Tree for TRIM48 (if available)

Paralogs for TRIM48 Gene

Pseudogenes.org Pseudogenes for TRIM48 Gene

genes like me logo Genes that share paralogs with TRIM48: view

Variants for TRIM48 Gene

Sequence variations from dbSNP and Humsavar for TRIM48 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000011305 -- 55,266,266(+) A/T intron_variant
rs1000131100 -- 55,263,435(+) T/C intron_variant
rs1000160530 -- 55,263,576(+) C/T intron_variant
rs1000334849 -- 55,268,410(+) C/G/T intron_variant
rs1000487384 -- 55,262,857(+) A/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM48 Gene

Variant ID Type Subtype PubMed ID
dgv1162n100 CNV gain+loss 25217958
dgv1163n100 CNV gain 25217958
dgv1164n100 CNV gain 25217958
dgv1165n100 CNV gain 25217958
dgv1166n100 CNV gain 25217958
dgv1167n100 CNV loss 25217958
dgv1168n100 CNV loss 25217958
dgv1865n54 CNV gain 21841781
dgv1903n54 CNV loss 21841781
dgv1904n54 CNV gain 21841781
dgv1905n54 CNV gain 21841781
dgv362e212 CNV gain 25503493
dgv366e212 CNV loss 25503493
dgv367e212 CNV loss 25503493
esv2421639 CNV deletion 20811451
esv2664161 CNV deletion 23128226
esv27386 CNV gain+loss 19812545
esv2751030 CNV gain 17911159
esv3547804 CNV deletion 23714750
esv3547805 CNV deletion 23714750
esv3584640 CNV loss 24956385
esv3626421 CNV loss 21293372
esv3626422 CNV gain 21293372
esv3892009 CNV gain 25118596
esv8902 CNV loss 19470904
nsv1078289 CNV deletion 25765185
nsv1159875 CNV duplication 26073780
nsv1159877 CNV duplication 26073780
nsv321 CNV deletion 18451855
nsv442616 CNV loss 18776908
nsv498756 CNV loss 21111241
nsv508631 CNV deletion 20534489
nsv512228 CNV loss 21212237
nsv524091 CNV gain 19592680
nsv554793 CNV gain 21841781
nsv554795 CNV loss 21841781
nsv832152 CNV gain+loss 17160897
nsv983020 CNV duplication 23825009

Variation tolerance for TRIM48 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.22% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM48 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM48

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM48 Gene

Disorders for TRIM48 Gene

Additional Disease Information for TRIM48

No disorders were found for TRIM48 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM48 Gene

Publications for TRIM48 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TRIM48 Gene

Sources for TRIM48 Gene

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