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Aliases for TRIM48 Gene

Aliases for TRIM48 Gene

  • Tripartite Motif Containing 48 2 3 5
  • Tripartite Motif-Containing 48 2 3
  • RING Finger Protein 101 3 4
  • RNF101 3 4

External Ids for TRIM48 Gene

Previous GeneCards Identifiers for TRIM48 Gene

  • GC11P056542
  • GC11P055278
  • GC11P054805
  • GC11P054786
  • GC11P055029
  • GC11P051358

Summaries for TRIM48 Gene

GeneCards Summary for TRIM48 Gene

TRIM48 (Tripartite Motif Containing 48) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is TRIM64C.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM48 Gene

Genomics for TRIM48 Gene

Regulatory Elements for TRIM48 Gene

Transcription factor binding sites by QIAGEN in the TRIM48 gene promoter:

Genomic Location for TRIM48 Gene

Chromosome:
11
Start:
55,262,182 bp from pter
End:
55,271,119 bp from pter
Size:
8,938 bases
Orientation:
Plus strand

Genomic View for TRIM48 Gene

Genes around TRIM48 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM48 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM48 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM48 Gene

Proteins for TRIM48 Gene

  • Protein details for TRIM48 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IWZ4-TRI48_HUMAN
    Recommended name:
    Tripartite motif-containing protein 48
    Protein Accession:
    Q8IWZ4
    Secondary Accessions:
    • Q9BUW4

    Protein attributes for TRIM48 Gene

    Size:
    208 amino acids
    Molecular mass:
    24498 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAO14946.1; Type=Erroneous termination; Positions=209; Note=Translated as stop.; Evidence={ECO:0000305};

neXtProt entry for TRIM48 Gene

Proteomics data for TRIM48 Gene at MOPED

Post-translational modifications for TRIM48 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TRIM48 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TRIM48 Gene

Domains & Families for TRIM48 Gene

Gene Families for TRIM48 Gene

Suggested Antigen Peptide Sequences for TRIM48 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IWZ4

UniProtKB/Swiss-Prot:

TRI48_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM48: view

Function for TRIM48 Gene

genes like me logo Genes that share phenotypes with TRIM48: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM48 Gene

Localization for TRIM48 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM48 Gene COMPARTMENTS Subcellular localization image for TRIM48 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
mitochondrion 1
plasma membrane 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM48 Gene

Pathways & Interactions for TRIM48 Gene

genes like me logo Genes that share pathways with TRIM48: view

Pathways by source for TRIM48 Gene

Gene Ontology (GO) - Biological Process for TRIM48 Gene

None

No data available for SIGNOR curated interactions for TRIM48 Gene

Drugs & Compounds for TRIM48 Gene

No Compound Related Data Available

Transcripts for TRIM48 Gene

mRNA/cDNA for TRIM48 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TRIM48 Gene

Tripartite motif containing 48:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM48 Gene

No ASD Table

Relevant External Links for TRIM48 Gene

GeneLoc Exon Structure for
TRIM48
ECgene alternative splicing isoforms for
TRIM48

Expression for TRIM48 Gene

mRNA expression in normal human tissues for TRIM48 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM48 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x39.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM48 Gene



SOURCE GeneReport for Unigene cluster for TRIM48 Gene Hs.195715

genes like me logo Genes that share expression patterns with TRIM48: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TRIM48 Gene

Orthologs for TRIM48 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TRIM48 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia -- 36
  • 24 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 25 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 21 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 16 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 14 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TRIM48 36
  • 97 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 21 (a)
ManyToMany
-- 36
  • 30 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 13 (a)
ManyToMany
-- 36
  • 14 (a)
ManyToMany
-- 36
  • 28 (a)
ManyToMany
-- 36
  • 11 (a)
ManyToMany
-- 36
  • 15 (a)
ManyToMany
-- 36
  • 17 (a)
ManyToMany
-- 36
  • 22 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii trim109 36
  • 10 (a)
ManyToMany
Species with no ortholog for TRIM48:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM48 Gene

ENSEMBL:
Gene Tree for TRIM48 (if available)
TreeFam:
Gene Tree for TRIM48 (if available)

Paralogs for TRIM48 Gene

genes like me logo Genes that share paralogs with TRIM48: view

Variants for TRIM48 Gene

Sequence variations from dbSNP and Humsavar for TRIM48 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs2864962 -- 55,260,833(+) TTCCA(A/G)TTGCC upstream-variant-2KB
rs2867252 -- 55,267,040(+) GTTAC(A/G)TATCT intron-variant
rs2867253 -- 55,267,514(+) AAGGG(A/G)AAAGA intron-variant
rs2867254 -- 55,267,531(+) TCATC(A/G)ACTTC intron-variant
rs2867255 -- 55,267,562(+) GCTCA(C/T)AGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM48 Gene

Variant ID Type Subtype PubMed ID
esv27386 CNV Gain+Loss 19812545
esv2751030 CNV Gain 17911159
nsv508631 CNV Loss 20534489
nsv524091 CNV Gain 19592680
nsv442616 CNV CNV 18776908
esv2421639 CNV Deletion 20811451
nsv832152 CNV Gain+Loss 17160897
nsv321 CNV Loss 18451855
nsv512228 CNV Loss 21212237
esv8902 CNV Loss 19470904
esv2664161 CNV Deletion 23128226
nsv498756 CNV Loss 21111241

Variation tolerance for TRIM48 Gene

Residual Variation Intolerance Score: 97.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.59; 65.22% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM48 Gene

HapMap Linkage Disequilibrium report
TRIM48

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM48 Gene

Disorders for TRIM48 Gene

Relevant External Links for TRIM48

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM48

No disorders were found for TRIM48 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM48 Gene

Publications for TRIM48 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TRIM48 Gene

Sources for TRIM48 Gene

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