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Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • GENEY 3 4
  • Tripartite Motif-Containing Protein 46 3
  • Tripartite Motif-Containing 46 2

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Innate Immune System. An important paralog of this gene is TRIM36.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

Regulatory Elements for TRIM46 Gene

Enhancers for TRIM46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G155242 1.5 ENCODE dbSUPER 11.7 +70.5 70456 2.9 CREB3L1 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 RUSC1-AS1 MSTO2P ASH1L THBS3 PYGO2 LOC101928120 GBA BGLAP
GH01G155206 1.4 ENCODE dbSUPER 11.8 +34.9 34900 4.5 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 SIN3A ARID4B DMAP1 ZNF2 THBS3 FAM189B SCAMP3 TRIM46 KRTCAP2 POU5F1P4 MTX1 LOC105371450
GH01G155240 1.3 ENCODE dbSUPER 11.7 +67.6 67632 1.6 PKNOX1 ARNT ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 ZHX2 HCN3 TRIM46 KRTCAP2 PKLR FDPS RUSC1 RUSC1-AS1 MIR555 ASH1L MUC1
GH01G155094 1.3 Ensembl ENCODE dbSUPER 11.3 -79.4 -79360 0.5 NFIB ARID4B KLF17 ZNF2 RAD21 ZEB1 RFX5 GLIS2 EGR1 KLF7 EFNA1 ENSG00000251246 EFNA4 SLC50A1 KRTCAP2 MUC1 ENSG00000231064 THBS3 MTX1 TRIM46
GH01G155231 1.1 Ensembl ENCODE dbSUPER 12 +58.4 58444 1.7 ARID1B TCF12 PKNOX1 POLR2A GLIS1 TAL1 NR2C1 SPI1 GBA FAM189B SCAMP3 THBS3 MTX1 MUC1 ENSG00000231064 KRTCAP2 TRIM46 FDPS
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM46 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000254614 -487 1401 HDGF MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9
ENSR00000014036 813 401 KLF1 KLF17 RBBP5 BMI1 ZIC2 ETS1 GLIS2 POLR2A PATZ1 ZNF600

Transcription factor binding sites by QIAGEN in the TRIM46 gene promoter:

Genomic Location for TRIM46 Gene

Chromosome:
1
Start:
155,173,787 bp from pter
End:
155,184,971 bp from pter
Size:
11,185 bases
Orientation:
Plus strand

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4K8-TRI46_HUMAN
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Q7Z4K8
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    Size:
    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM46 Gene

Post-translational modifications for TRIM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4K8

UniProtKB/Swiss-Prot:

TRI46_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0043194 axon initial segment IEA --
GO:1904115 axon cytoplasm IEA --
GO:1990769 proximal neuron projection IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM46 Gene

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Interacting Proteins for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0001764 neuron migration IEA --
GO:0007409 axonogenesis IEA --
GO:0048490 anterograde synaptic vesicle transport IEA --
GO:0099612 protein localization to axon IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for SIGNOR curated interactions for TRIM46 Gene

Drugs & Compounds for TRIM46 Gene

No Compound Related Data Available

Transcripts for TRIM46 Gene

Unigene Clusters for TRIM46 Gene

Tripartite motif containing 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
TRIM46
ECgene alternative splicing isoforms for
TRIM46

Expression for TRIM46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM46 Gene



Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM46 Gene:

TRIM46

SOURCE GeneReport for Unigene cluster for TRIM46 Gene:

Hs.287735

Evidence on tissue expression from TISSUES for TRIM46 Gene

  • Nervous system(4.6)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TRIM46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM46 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia TRIM46 34 35
  • 92.89 (n)
dog
(Canis familiaris)
Mammalia TRIM46 34 35
  • 92.89 (n)
mouse
(Mus musculus)
Mammalia Trim46 34 16 35
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM46 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim46 34
  • 86.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM46 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim46b 34 35
  • 63.77 (n)
TRIM46 (1 of 2) 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Trim9 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 35
  • 19 (a)
OneToMany
Species where no ortholog for TRIM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

ENSEMBL:
Gene Tree for TRIM46 (if available)
TreeFam:
Gene Tree for TRIM46 (if available)

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations from dbSNP and Humsavar for TRIM46 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000388388 -- 155,174,402(+) GGGAT(G/T)ATGTA intron-variant, upstream-variant-2KB
rs1000453944 -- 155,181,113(+) CAGGC(A/G)CCTGT intron-variant
rs1000567890 -- 155,179,869(+) CCGCG(A/G)CTGCA nc-transcript-variant, reference, missense
rs1000594297 -- 155,174,474(+) CCCCA(C/G)TCAGG intron-variant, upstream-variant-2KB
rs1000687791 -- 155,173,146(+) CGGGA(A/G)AGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Relevant External Links for TRIM46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM46

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short K.M. … Cox T.C. (J. Biol. Chem. 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3 64

Products for TRIM46 Gene

Sources for TRIM46 Gene

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