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Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • GENEY 3 4
  • Tripartite Motif-Containing Protein 46 3
  • Tripartite Motif-Containing 46 2

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Innate Immune System. An important paralog of this gene is TRIM36.

UniProtKB/Swiss-Prot for TRIM46 Gene

  • Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Additional gene information for TRIM46 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

GeneHancer (GH) Regulatory Elements for TRIM46 Gene

Promoters and enhancers for TRIM46 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I155172 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 550.8 +2.0 1962 7.3 HDGF SMAD1 FOXA2 MLX ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 KRTCAP2 TRIM46 GBAP1 ADAM15 MUC1 POU5F1P4 ENSG00000273088
GH01I155242 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 22.6 +70.5 70455 2.9 FEZF1 YBX1 IRF4 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 GBA KHDC4 GON4L CLK2 ENSG00000271267 MSTO1 MSTO2P RUSC1-AS1 THBS3 SHC1
GH01I156111 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.9 +947.6 947602 19.4 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 LMNA GON4L CLK2 RRNAD1 KHDC4 LOC246784 MSTO1 MSTO2P PRCC ISG20L2
GH01I155206 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.8 +34.9 34900 4.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 THBS3 MTX1 FAM189B SCAMP3 TRIM46 KRTCAP2 LMNA DAP3 POU5F1P4 LOC105371450
GH01I155191 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.2 +21.4 21415 6.5 HDGF PKNOX1 CLOCK SMAD1 ARNT ZFP64 ARID4B SIN3A ZNF2 POLR2B ENSG00000231064 MUC1 GC01P155206 LOC105371450 MIR92B CLK2 GBAP1 GON4L UBAP2L KHDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TRIM46 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TRIM46 gene promoter:

Genomic Locations for TRIM46 Gene

Genomic Locations for TRIM46 Gene
chr1:155,173,787-155,184,971
(GRCh38/hg38)
Size:
11,185 bases
Orientation:
Plus strand
chr1:155,145,873-155,157,447
(GRCh37/hg19)

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4K8-TRI46_HUMAN
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Q7Z4K8
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    Size:
    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    • Interacts with TUBB3 and TUBA4A.

    Alternative splice isoforms for TRIM46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM46 Gene

Post-translational modifications for TRIM46 Gene

No Post-translational modifications

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4K8

UniProtKB/Swiss-Prot:

TRI46_HUMAN :
  • Belongs to the TRIM/RBCC family.
Family:
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Molecular function for TRIM46 Gene

UniProtKB/Swiss-Prot Function:
Microtubule-associated protein that is involved in the formation of parallel microtubule bundles linked by cross-bridges in the proximal axon. Required for the uniform orientation and maintenance of the parallel microtubule fascicles, which are important for efficient cargo delivery and trafficking in axons. Thereby also required for proper axon specification, the establishment of neuronal polarity and proper neuronal migration.

Phenotypes From GWAS Catalog for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

miRNA for TRIM46 Gene

miRTarBase miRNAs that target TRIM46

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM46 Gene

Cell projection, axon. Cytoplasm, cytoskeleton. Note=Microtubule-associated. Localizes to the proximal part of the axon. {ECO:0000250 UniProtKB:Q7TNM2}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
cytoskeleton 4
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0030424 axon IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with TRIM46: view

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Interacting Proteins for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0001764 neuron migration IEA --
GO:0007409 axonogenesis IEA --
GO:0048490 anterograde synaptic vesicle transport IEA --
GO:0099612 protein localization to axon IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for SIGNOR curated interactions for TRIM46 Gene

Drugs & Compounds for TRIM46 Gene

No Compound Related Data Available

Transcripts for TRIM46 Gene

Unigene Clusters for TRIM46 Gene

Tripartite motif containing 46:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
TRIM46
ECgene alternative splicing isoforms for
TRIM46

Expression for TRIM46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM46 Gene



Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM46 Gene:

TRIM46

SOURCE GeneReport for Unigene cluster for TRIM46 Gene:

Hs.287735

Evidence on tissue expression from TISSUES for TRIM46 Gene

  • Nervous system(4.6)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TRIM46: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM46 33 34
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia TRIM46 33 34
  • 92.89 (n)
dog
(Canis familiaris)
Mammalia TRIM46 33 34
  • 92.89 (n)
mouse
(Mus musculus)
Mammalia Trim46 33 16 34
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM46 34
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim46 33
  • 86.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM46 34
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim46b 33 34
  • 63.77 (n)
TRIM46 (1 of 2) 34
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Trim9 34
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 34
  • 19 (a)
OneToMany
Species where no ortholog for TRIM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

ENSEMBL:
Gene Tree for TRIM46 (if available)
TreeFam:
Gene Tree for TRIM46 (if available)

Paralogs for TRIM46 Gene

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations from dbSNP and Humsavar for TRIM46 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000388388 -- 155,174,402(+) G/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000453944 -- 155,181,113(+) G/A downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000567890 -- 155,179,869(+) G/A coding_sequence_variant, missense_variant, non_coding_transcript_variant
rs1000594297 -- 155,174,474(+) C/G genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000687791 -- 155,173,146(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TRIM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Additional Disease Information for TRIM46

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short KM … Cox TC (The Journal of biological chemistry 2006) 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 58
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) Köttgen A … Gieger C (Nature genetics 2013) 3 58

Products for TRIM46 Gene

Sources for TRIM46 Gene

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