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Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • GENEY 3 4
  • Tripartite Motif-Containing Protein 46 3
  • Tripartite Motif-Containing 46 2

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Immune System. An important paralog of this gene is TRIM36.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

Regulatory Elements for TRIM46 Gene

Enhancers for TRIM46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F155211 0.2 ENCODE 12.6 +37.7 37704 0.9 ZBTB33 TRIM46 KRTCAP2 FAM189B SCAMP3 FDPS ENSG00000236263 THBS3
GH01F155231 1.1 Ensembl ENCODE 11.9 +58.4 58444 1.7 ARID1B PKNOX1 POLR2A GLIS1 SPI1 GBA FAM189B SCAMP3 THBS3 MTX1 MIR92B MUC1 KRTCAP2 TRIM46 FDPS
GH01F155206 0.5 ENCODE 11.8 +34.9 34900 4.5 HDGF PKNOX1 CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 THBS3 FAM189B SCAMP3 TRIM46 KRTCAP2 POU5F1P4 MTX1 LOC105371450
GH01F155242 0.6 ENCODE 11.7 +70.5 70456 2.9 CREB3L1 YBX1 FEZF1 YY1 ZNF416 ZNF143 ZNF548 ZNF263 SP3 TBX21 KIAA0907 ENSG00000271267 MSTO2P RUSC1-AS1 THBS3 ASH1L PYGO2 LOC101928120 KRTCAP2 GBA
GH01F155240 0.2 ENCODE 11.7 +67.6 67632 1.6 PKNOX1 ATF1 ARNT ARID4B SIN3A DMAP1 ETS1 YY1 ZNF121 ELK1 KRTCAP2 HCN3 TRIM46 PKLR FDPS RUSC1 RUSC1-AS1 ASH1L MIR555 THBS3
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TRIM46 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000545514 13 2801 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207

Genomic Location for TRIM46 Gene

Chromosome:
1
Start:
155,173,787 bp from pter
End:
155,184,971 bp from pter
Size:
11,185 bases
Orientation:
Plus strand

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z4K8-TRI46_HUMAN
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Q7Z4K8
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    Size:
    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM46 Gene

Post-translational modifications for TRIM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Graphical View of Domain Structure for InterPro Entry

Q7Z4K8

UniProtKB/Swiss-Prot:

TRI46_HUMAN :
  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
Domain:
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 1 B box-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM46 Gene COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

Gene Ontology (GO) - Cellular Components for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM46 Gene

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene

None

No data available for SIGNOR curated interactions for TRIM46 Gene

Transcripts for TRIM46 Gene

Unigene Clusters for TRIM46 Gene

Tripartite motif containing 46:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP1:
SP2: - -
SP3:
SP4: - - -
SP5: - -
SP6:

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
TRIM46
ECgene alternative splicing isoforms for
TRIM46

Expression for TRIM46 Gene

mRNA expression in normal human tissues for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM46 Gene



Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM46 Gene:

TRIM46

SOURCE GeneReport for Unigene cluster for TRIM46 Gene:

Hs.287735
genes like me logo Genes that share expression patterns with TRIM46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TRIM46 34 35
  • 99.74 (n)
cow
(Bos Taurus)
Mammalia TRIM46 34 35
  • 92.89 (n)
dog
(Canis familiaris)
Mammalia TRIM46 34 35
  • 92.89 (n)
mouse
(Mus musculus)
Mammalia Trim46 34 16 35
  • 90.65 (n)
oppossum
(Monodelphis domestica)
Mammalia TRIM46 35
  • 89 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim46 34
  • 86.91 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TRIM46 35
  • 65 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii trim46b 34 35
  • 63.77 (n)
TRIM46 (1 of 2) 35
  • 58 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Trim9 35
  • 21 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea trim-9 35
  • 19 (a)
OneToMany
Species where no ortholog for TRIM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

ENSEMBL:
Gene Tree for TRIM46 (if available)
TreeFam:
Gene Tree for TRIM46 (if available)

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations from dbSNP and Humsavar for TRIM46 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs111508230 -- 155,181,061(+) AACCC(C/T)GTCTC intron-variant
rs111910059 -- 155,180,601(+) CGGAA(-/AAAT)AAATA intron-variant, nc-transcript-variant, utr-variant-3-prime
rs111990855 -- 155,182,015(+) GGCGA(C/T)GTGGC nc-transcript-variant, downstream-variant-500B, reference, synonymous-codon
rs112636963 -- 155,173,369(+) CTGGA(C/T)GCAGC upstream-variant-2KB
rs11264340 -- 155,172,394(+) CAACT(C/T)CAGGA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TRIM46

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Relevant External Links for TRIM46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM46

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short K.M. … Cox T.C. (J. Biol. Chem. 2006) 3 4 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3 64
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3 64

Products for TRIM46 Gene

Sources for TRIM46 Gene

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