Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • GENEY 3 4
  • Tripartite Motif-Containing 46 2

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is MID1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

Regulatory Elements for TRIM46 Gene

Promoters for TRIM46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM46 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TRIM46 gene promoter:

Genomic Location for TRIM46 Gene

155,173,787 bp from pter
155,184,971 bp from pter
11,185 bases
Plus strand

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM46 Gene


neXtProt entry for TRIM46 Gene

Proteomics data for TRIM46 Gene at MOPED

Post-translational modifications for TRIM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 B30.2/SPRY domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 1 B30.2/SPRY domain.
  • Contains 1 COS domain.
  • Contains 1 fibronectin type-III domain.
  • Belongs to the TRIM/RBCC family.
  • Contains 1 B box-type zinc finger.
  • Contains 2 RING-type zinc fingers.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from

Jensen Localization Image for TRIM46 Gene COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
cytosol 3
nucleus 3
cytoskeleton 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for TRIM46 Gene

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene


No data available for SIGNOR curated interactions for TRIM46 Gene

Drugs & Compounds for TRIM46 Gene

No Compound Related Data Available

Transcripts for TRIM46 Gene

Unigene Clusters for TRIM46 Gene

Tripartite motif containing 46:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - -
SP4: - - -
SP5: - -

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM46 Gene

mRNA expression in normal human tissues for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM46 Gene

SOURCE GeneReport for Unigene cluster for TRIM46 Gene Hs.287735

genes like me logo Genes that share expression patterns with TRIM46: view

Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TRIM46 35
  • 92.89 (n)
  • 98.55 (a)
TRIM46 36
  • 99 (a)
(Canis familiaris)
Mammalia TRIM46 35
  • 92.89 (n)
  • 98.55 (a)
TRIM46 36
  • 99 (a)
(Mus musculus)
Mammalia Trim46 35
  • 90.65 (n)
  • 97.89 (a)
Trim46 16
Trim46 36
  • 98 (a)
(Pan troglodytes)
Mammalia TRIM46 35
  • 99.74 (n)
  • 100 (a)
TRIM46 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Trim46 35
  • 86.91 (n)
  • 92.51 (a)
(Monodelphis domestica)
Mammalia TRIM46 36
  • 89 (a)
(Ornithorhynchus anatinus)
Mammalia TRIM46 36
  • 65 (a)
(Danio rerio)
Actinopterygii trim46b 35
  • 63.77 (n)
  • 62.34 (a)
TRIM46 (1 of 2) 36
  • 58 (a)
trim46b 36
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trim9 36
  • 21 (a)
(Caenorhabditis elegans)
Secernentea trim-9 36
  • 19 (a)
Species with no ortholog for TRIM46:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

Gene Tree for TRIM46 (if available)
Gene Tree for TRIM46 (if available)

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations from dbSNP and Humsavar for TRIM46 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs2070803 -- 155,185,239(-) TCCCT(C/T)GACCG downstream-variant-500B
rs3814316 -- 155,177,242(-) TGTAC(C/T)GTGTC nc-transcript-variant, reference, synonymous-codon
rs3186176 -- 155,184,707(+) CCCAA(A/C)ACCCC nc-transcript-variant, utr-variant-3-prime
rs4971059 -- 155,176,305(+) ATTGT(A/G)GGTTT intron-variant
rs4971099 -- 155,183,132(+) GTCTC(A/G)ATCTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
nsv464084 CNV Loss 19166990
dgv3n68 CNV Loss 17160897
dgv132e1 CNV Complex 17122850
nsv470741 CNV Loss 18288195
nsv872457 CNV Loss 21882294
nsv8447 CNV Gain 18304495
nsv872458 CNV Loss 21882294
dgv390n71 CNV Loss 21882294
nsv527682 CNV Gain 19592680
nsv872460 CNV Loss 21882294
nsv2988 CNV Insertion 18451855
dgv391n71 CNV Loss 21882294

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM46 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Relevant External Links for TRIM46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short K.M. … Cox T.C. (J. Biol. Chem. 2006) 3 4 67
  2. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal K.B. … Olsen J.V. (Sci Signal 2015) 3
  3. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) KAPttgen A. … Gieger C. (Nat. Genet. 2013) 3
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  5. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PMID: 23105109) Hayes S.D. … UrbAc S. (J. Biol. Chem. 2012) 3

Products for TRIM46 Gene

Sources for TRIM46 Gene

Back to Top