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Aliases for TRIM46 Gene

Aliases for TRIM46 Gene

  • Tripartite Motif Containing 46 2 3 5
  • Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein 3 4
  • Gene Y Protein 3 4
  • TRIFIC 3 4
  • GENEY 3 4
  • Tripartite Motif-Containing Protein 46 3
  • Tripartite Motif-Containing 46 2

External Ids for TRIM46 Gene

Previous GeneCards Identifiers for TRIM46 Gene

  • GC01P150886
  • GC01P151921
  • GC01P152363
  • GC01P151959
  • GC01P153412
  • GC01P155146
  • GC01P126508

Summaries for TRIM46 Gene

GeneCards Summary for TRIM46 Gene

TRIM46 (Tripartite Motif Containing 46) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. An important paralog of this gene is TRIM36.

Additional gene information for TRIM46 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM46 Gene

Genomics for TRIM46 Gene

Regulatory Elements for TRIM46 Gene

Enhancers for TRIM46 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H155242 1.5 ENCODE dbSUPER 22.6 +70.5 70456 2 FEZF1 YBX1 YY1 ZNF416 ZNF143 ZNF548 SP3 ZFP41 MEF2D ZNF610 KIAA0907 GON4L ENSG00000271267 CLK2 MSTO1 MSTO2P THBS3 RUSC1-AS1 LOC101928120 SHC1
GH01H156111 1.8 FANTOM5 ENCODE dbSUPER 10.9 +947.6 947603 19 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 ZNF548 SP3 GON4L CLK2 RRNAD1 KIAA0907 LOC246784 LMNA MSTO1 MSTO2P PRCC ISG20L2
GH01H155094 1.4 Ensembl ENCODE dbSUPER 11.3 -79.4 -79360 0 NFIB ARID4B KLF17 ZNF2 RAD21 ZEB1 RFX5 GLIS2 EGR1 ZNF143 EFNA1 EFNA4 ENSG00000251246 SLC50A1 KRTCAP2 MUC1 ENSG00000231064 MTX1 THBS3 TRIM46
GH01H155191 1.4 ENCODE dbSUPER 11.2 +21.4 21416 6 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A ZNF2 ZNF766 ZNF207 ZNF143 GBAP1 CLK2 GON4L UBAP2L LMNA FLAD1 KIAA0907 SYT11 ENSG00000246203 MSTO1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM46 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM46 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000254614 -487 1401 HDGF MLX ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF207
ENSR00000014036 813 401 KLF1 KLF17 BMI1 ZIC2 ETS1 GLIS2 POLR2A PATZ1 ZNF600 EZH2

Transcription factor binding sites by QIAGEN in the TRIM46 gene promoter:

Genomic Location for TRIM46 Gene

155,173,787 bp from pter
155,184,971 bp from pter
11,185 bases
Plus strand

Genomic View for TRIM46 Gene

Genes around TRIM46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM46 Gene

Proteins for TRIM46 Gene

  • Protein details for TRIM46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 46
    Protein Accession:
    Secondary Accessions:
    • A0AVI6
    • B1AVQ4
    • Q5VT60
    • Q5VT62
    • Q6NT17
    • Q6NT41
    • Q6ZRL7
    • Q9H5P2

    Protein attributes for TRIM46 Gene

    759 amino acids
    Molecular mass:
    83424 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TRIM46 Gene


neXtProt entry for TRIM46 Gene

Post-translational modifications for TRIM46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TRIM46 Gene

Domains & Families for TRIM46 Gene

Gene Families for TRIM46 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM46: view

Function for TRIM46 Gene

Phenotypes From GWAS Catalog for TRIM46 Gene

Gene Ontology (GO) - Molecular Function for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM46: view
genes like me logo Genes that share phenotypes with TRIM46: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TRIM46 Gene

Localization for TRIM46 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM46 gene
Compartment Confidence
nucleus 3
cytosol 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Intermediate filaments (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0043194 axon initial segment IEA --
GO:1904115 axon cytoplasm IEA --
GO:1990769 proximal neuron projection IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for TRIM46 Gene

Pathways & Interactions for TRIM46 Gene

genes like me logo Genes that share pathways with TRIM46: view

Pathways by source for TRIM46 Gene

Interacting Proteins for TRIM46 Gene

Gene Ontology (GO) - Biological Process for TRIM46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001578 microtubule bundle formation IEA --
GO:0001764 neuron migration IEA --
GO:0007409 axonogenesis IEA --
GO:0048490 anterograde synaptic vesicle transport IEA --
GO:0099612 protein localization to axon IEA --
genes like me logo Genes that share ontologies with TRIM46: view

No data available for SIGNOR curated interactions for TRIM46 Gene

Drugs & Compounds for TRIM46 Gene

No Compound Related Data Available

Transcripts for TRIM46 Gene

Unigene Clusters for TRIM46 Gene

Tripartite motif containing 46:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
SP2: - -
SP4: - - -
SP5: - -

Relevant External Links for TRIM46 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM46 Gene

mRNA differential expression in normal tissues according to GTEx for TRIM46 Gene

This gene is overexpressed in Brain - Cerebellum (x6.1) and Brain - Cerebellar Hemisphere (x5.5).

Protein differential expression in normal tissues from HIPED for TRIM46 Gene

This gene is overexpressed in Fetal Brain (34.9), Platelet (26.2), and Frontal cortex (7.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM46 Gene

Protein tissue co-expression partners for TRIM46 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TRIM46 Gene:


SOURCE GeneReport for Unigene cluster for TRIM46 Gene:


Evidence on tissue expression from TISSUES for TRIM46 Gene

  • Nervous system(4.6)
  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TRIM46: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM46 Gene

Orthologs for TRIM46 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM46 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM46 33 34
  • 99.74 (n)
(Bos Taurus)
Mammalia TRIM46 33 34
  • 92.89 (n)
(Canis familiaris)
Mammalia TRIM46 33 34
  • 92.89 (n)
(Mus musculus)
Mammalia Trim46 33 16 34
  • 90.65 (n)
(Monodelphis domestica)
Mammalia TRIM46 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Trim46 33
  • 86.91 (n)
(Ornithorhynchus anatinus)
Mammalia TRIM46 34
  • 65 (a)
(Danio rerio)
Actinopterygii trim46b 33 34
  • 63.77 (n)
TRIM46 (1 of 2) 34
  • 58 (a)
fruit fly
(Drosophila melanogaster)
Insecta Trim9 34
  • 21 (a)
(Caenorhabditis elegans)
Secernentea trim-9 34
  • 19 (a)
Species where no ortholog for TRIM46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TRIM46 Gene

Gene Tree for TRIM46 (if available)
Gene Tree for TRIM46 (if available)

Paralogs for TRIM46 Gene

(3) SIMAP similar genes for TRIM46 Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TRIM46: view

Variants for TRIM46 Gene

Sequence variations from dbSNP and Humsavar for TRIM46 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000388388 -- 155,174,402(+) GGGAT(G/T)ATGTA intron-variant, upstream-variant-2KB
rs1000453944 -- 155,181,113(+) CAGGC(A/G)CCTGT intron-variant
rs1000567890 -- 155,179,869(+) CCGCG(A/G)CTGCA nc-transcript-variant, reference, missense
rs1000594297 -- 155,174,474(+) CCCCA(C/G)TCAGG intron-variant, upstream-variant-2KB
rs1000687791 -- 155,173,146(+) CGGGA(A/G)AGGAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TRIM46 Gene

Variant ID Type Subtype PubMed ID
dgv3n68 CNV loss 17160897
esv2758971 CNV gain 17122850
esv3587615 CNV gain 21293372
nsv1010146 CNV gain 25217958
nsv2988 CNV insertion 18451855
nsv464084 CNV loss 19166990
nsv470741 CNV loss 18288195
nsv527682 CNV gain 19592680
nsv547961 CNV loss 21841781
nsv8447 CNV gain 18304495

Variation tolerance for TRIM46 Gene

Residual Variation Intolerance Score: 7.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.50; 43.70% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM46 Gene

Disorders for TRIM46 Gene

Relevant External Links for TRIM46

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM46 Gene

Publications for TRIM46 Gene

  1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PMID: 16434393) Short KM … Cox TC (The Journal of biological chemistry 2006) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation. (PMID: 25921289) Emdal KB … Olsen JV (Science signaling 2015) 3 60
  5. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PMID: 23263486) Köttgen A … Gieger C (Nature genetics 2013) 3 60

Products for TRIM46 Gene

Sources for TRIM46 Gene

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