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TRIM46 Gene

protein-coding   GIFtS: 47
GCID: GC01P155146

Tripartite Motif Containing 46

(Previous name: tripartite motif-containing 46)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 461 2     GENEY2 5
Gene Y Protein2 3     Tripartite Motif-Containing 461
Tripartite, Fibronectin Type-III And C-Terminal SPRY Motif Protein2 3     Tripartite Motif-Containing Protein 462
TRIFIC2 3     GeneY3

External Ids:    HGNC: 190191   Entrez Gene: 801282   Ensembl: ENSG000001634627   OMIM: 6009865   UniProtKB: Q7Z4K83   

Export aliases for TRIM46 gene to outside databases

Previous GC identifers: GC01P150886 GC01P151921 GC01P152363 GC01P151959 GC01P153412 GC01P126508


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TRIM46 Gene:
TRIM46 (tripartite motif containing 46) is a protein-coding gene. Diseases associated with TRIM46 include cblc. An important paralog of this gene is TRIM13.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM46 gene promoter:
         AP-1   HTF   ATF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM46 promoter sequence
   Search Chromatin IP Primers for TRIM46

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM46


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

TRIM46 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM46 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155146:  view genomic region     (about GC identifiers)

Start:
155,145,873 bp from pter      End:
155,157,447 bp from pter
Size:
11,575 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI46_HUMAN, Q7Z4K8 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 46  
Size: 759 amino acids; 83424 Da
Secondary accessions: A0AVI6 B1AVQ4 Q5VT60 Q5VT62 Q6NT17 Q6NT41 Q6ZRL7 Q9H5P2
Alternative splicing: 5 isoforms:  Q7Z4K8-1   Q7Z4K8-2   Q7Z4K8-3   Q7Z4K8-4   Q7Z4K8-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM46: NX_Q7Z4K8

Explore proteomics data for TRIM46 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TRIM46 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (6 alternative transcripts): 
    NP_001243528.1  NP_001243529.1  NP_001243530.1  NP_001269307.1  NP_001269308.1  NP_079334.3  

    ENSEMBL proteins: 
     ENSP00000357369   ENSP00000357367   ENSP00000357366   ENSP00000334657   ENSP00000442719  
     ENSP00000376245   ENSP00000440254  

    TRIM46 Human Recombinant Protein Products:

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    Novus Biologicals TRIM46 Protein
    Novus Biologicals TRIM46 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TRIM46

    TRIM46 Antibody Products:

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    LSBio Antibodies in human, mouse, rat for TRIM46

    TRIM46 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TRIM46
    Cloud-Clone Corp. CLIAs for TRIM46


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 10):
     IPR017907 Znf_RING_CS
     IPR001841 Znf_RING
     IPR001870 B30.2/SPRY
     IPR017903 COS_domain
     IPR003961 Fibronectin_type3

    Graphical View of Domain Structure for InterPro Entry Q7Z4K8

    ProtoNet protein and cluster: Q7Z4K8

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI46_HUMAN, Q7Z4K8
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 1 B box-type zinc finger
    Similarity: Contains 1 B30.2/SPRY domain
    Similarity: Contains 1 COS domain
    Similarity: Contains 1 fibronectin type-III domain
    Similarity: Contains 2 RING-type zinc fingers


    TRIM46 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
    GO:0046872metal ion binding ----
         
    TRIM46 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TRIM46:
     Synthetic lethal with Ras 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM46
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM46

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM46
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM46

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TRIM46 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM46 (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-27a hsa-miR-128 hsa-miR-1271 hsa-miR-3681* hsa-miR-3175 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidTRIM46 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM46
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM46

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TRIM46

    Clone
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    OriGene ORF clones in mouse, rat for TRIM46
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM46 (NM_025058)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM46
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM46

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for TRIM46
    Browse ESI BIO Cell Lines and PureStem Progenitors for TRIM46 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM46


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    cytoskeleton1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular IEA--

    TRIM46 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TRIM46
    Interactions:

        Search GeneGlobe Interaction Network for TRIM46

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for TRIM46 (Q7Z4K82, 3 ENSP000003346574) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TK1P041832, 3MINT-8274247 I2D: score=2 
    TSG101Q998163, ENSP000002519684I2D: score=2 STRING: ENSP00000251968
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    UBE2ZQ9H8323, ENSP000003542014I2D: score=2 STRING: ENSP00000354201
    AK5Q9Y6K83I2D: score=4 
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM46 (TRI46)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TRIM46 gene (6 alternative transcripts): 
    NM_001256599.1  NM_001256600.1  NM_001256601.1  NM_001282378.1  NM_001282379.1  NM_025058.4  

    Unigene Cluster for TRIM46:

    Tripartite motif containing 46
    Hs.287735  [show with all ESTs]
    Unigene Representative Sequence: NR_046329
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368385(uc010pez.1 uc001fhq.3 uc001fhr.3) ENST00000368383(uc009wpg.1)
    ENST00000474430(uc009wpe.1) ENST00000368382(uc001fhu.1) ENST00000334634
    ENST00000464760(uc009wpf.2) ENST00000468878(uc001fhw.1) ENST00000543729
    ENST00000392451(uc001fhs.1 uc001fht.1 uc010pfa.1) ENST00000545012

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TRIM46 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TRIM46 (see all 13):
    hsa-miR-455-5p hsa-miR-550a hsa-miR-27a hsa-miR-128 hsa-miR-1271 hsa-miR-3681* hsa-miR-3175 hsa-miR-3142
    SwitchGear 3'UTR luciferase reporter plasmidTRIM46 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TRIM46
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM46
    Clone
    Products:
         
    OriGene clones in human, mouse for TRIM46 (see all 8)
    OriGene ORF clones in mouse, rat for TRIM46
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TRIM46 (NM_025058)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM46
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM46
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM46
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM46
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM46
      QuantiFast Probe-based Assays in human, mouse, rat TRIM46

    Additional mRNA sequence: 

    AK026882.1 AK090504.1 AK096158.1 AK128139.1 AK225075.1 AK296300.1 AK297318.1 AK304542.1 
    AK308075.1 AK309699.1 AK310429.1 AY251386.1 BC069416.1 BC069568.1 BC126372.1 BC143828.1 
    NR_046327.1 NR_046328.1 NR_046329.1 

    15 DOTS entries:

    DT.102822540  DT.121335552  DT.110993  DT.121335530  DT.101979694  DT.91682793  DT.121335534  DT.100754586 
    DT.121335477  DT.121335536  DT.91702489  DT.100845149  DT.100020974  DT.121335550  DT.101961664 

    Selected AceView cDNA sequences (see all 27):

    AK128139 AK096158 NM_025058 CR601445 CD108922 BX327092 BC069416 AK026882 
    BX376350 BQ928969 BG743891 CD632411 BC069568 CD632423 CD632415 CD632413 
    CD632407 CD632421 BG744577 AY251386 BX283909 CD632424 CD632409 BX376349 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TRIM46 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12
    SP1:                                                                                                      
    SP2:              -     -                                                                                 
    SP3:                                                                                                      
    SP4:              -     -     -                                                                           
    SP5:                    -     -                                                                           


    ECgene alternative splicing isoforms for TRIM46

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM46 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTTTATAAAC
    TRIM46 Expression
    About this image

    TRIM46 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM46 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.287735
        Custom PCR Arrays for TRIM46
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM46

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM46 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim461 , 5 tripartite motif-containing 461, 5 90.65(n)1
    97.89(a)1
      3 (39.02 cM)5
    3602131  NM_183037.21  NP_898858.11 
     892341775 
    zebrafish
    (Danio rerio)
    Actinopterygii trim46b1 tripartite motif containing 46b 63.77(n)
    62.34(a)
      100034631  NM_001083100.1  NP_001076569.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Trim96
    Trim9
    21(a)
    1 → many
    2L(10544881-10627374)
    worm
    (Caenorhabditis elegans)
    Secernentea trim-96
    Protein TRIM-9, isoform b (trim-9) mRNA, complete ...
    19(a)
    1 → many
    V(1223897-1235445) WBGene00016539


    ENSEMBL Gene Tree for TRIM46 (if available)
    TreeFam Gene Tree for TRIM46 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM46 gene
    TRIM132  FSD1L2  TRIM632  TRIM592  TRIM92  TRIM672  TRIM362  TRIM552  
    MID12  MID22  TRIM542  FSD12  
    3 SIMAP similar genes for TRIM46 using alignment to 4 protein entries:     TRI46_HUMAN (see all proteins):
    TRIM36    TRIM39    MID1

    TRIM46 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM46 (see all 233)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1811849871,2
    C--155147889(+) AGGAAC/GTGCTG 11 L V mis1 int10--------
    rs1431898841,2
    C--155148157(+) GGGAAC/TGCTGA 7 -- int10--------
    rs1862725081,2
    --155148209(+) AGGCAC/TCTGTC 7 -- int10--------
    rs2011203401,2
    --155148325(+) CAGCTC/GTAACT 7 -- int10--------
    rs1475200181,2
    C--155148429(+) CGTGCC/GCAGCC 11 P A mis10--------
    rs2007942601,2
    C--155148462(+) GGGAGC/TGGGGT 11 R W mis11Minor allele frequency- T:0.00EU 1265
    rs1883007901,2
    C--155148519(+) GGTACC/TGCCAG 11 R C mis10--------
    rs802548671,2
    C,F--155148520(+) GTACCG/ACCAGA 11 /H /R mis12Minor allele frequency- A:0.01NA EU 5719
    rs2006304131,2
    C--155148740(+) AGGGAA/GGGACA 7 -- int10--------
    rs121378501,2
    C,F,H--155148779(+) GCATTG/TTGGGT 7 -- int14Minor allele frequency- T:0.01NS EA 408

    HapMap Linkage Disequilibrium report for TRIM46 (155145873 - 155157447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TRIM46 (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv2988CNV Insertion18451855
    dgv391n71CNV Loss21882294
    dgv3n68CNV Loss17160897
    nsv872458CNV Loss21882294
    nsv464084CNV Loss19166990
    nsv872460CNV Loss21882294
    nsv470741CNV Loss18288195
    nsv872457CNV Loss21882294
    dgv390n71CNV Loss21882294
    nsv527682CNV Gain19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM46
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM46

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600986    OMIM disorders: --

    1 disease for TRIM46:    
    About MalaCards
    cblc


    TRIM46 for disorders           About GeneDecksing


    Export disorders for TRIM46 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM46 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with TRIM46)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Subclassification of the RBCC/TRIM superfamily reveals a novel motif necessary for microtubule binding. (PubMed id 16434393)1, 2 Short K.M. and Cox T.C. (J. Biol. Chem. 2006)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. (PubMed id 23263486)1 KAPttgen A....Gieger C. (Nat. Genet. 2013)
    5. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    6. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    7. Direct and indirect control of mitogen-activated protein kinase pathway-associated components, BRAP/IMP E3 ubiquitin ligase and CRAF/RAF1 kinase, by the deubiquitylating enzyme USP15. (PubMed id 23105109)1 Hayes S.D....UrbAc S. (J. Biol. Chem. 2012)
    8. A directed protein interaction network for investigating intracellular signal transduction. (PubMed id 21900206)1 Vinayagam A....Wanker E.E. (Sci Signal 2011)
    9. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PubMed id 20467438)1 Arbuckle M.I....Grant S.G. (EMBO Rep. 2010)
    10. Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network. (PubMed id 19549727)1 Markson G....Sanderson C.M. (Genome Res. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    OMIM
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80128 HGNC: 19019 AceView: TRIM46 Ensembl:ENSG00000163462 euGenes: HUgn80128
    ECgene: TRIM46 H-InvDB: TRIM46

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TRIM46 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM46 gene:
    Search GeneIP for patents involving TRIM46

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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