Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TRIM45 Gene

Aliases for TRIM45 Gene

  • Tripartite Motif Containing 45 2 3 5
  • RNF99 3 4
  • Tripartite Motif-Containing Protein 45 3
  • Tripartite Motif-Containing 45 2
  • Ring Finger Protein 99 3
  • RING Finger Protein 99 4

External Ids for TRIM45 Gene

Previous GeneCards Identifiers for TRIM45 Gene

  • GC01M116493
  • GC01M116801
  • GC01M117001
  • GC01M117365
  • GC01M117654
  • GC01M115511

Summaries for TRIM45 Gene

Entrez Gene Summary for TRIM45 Gene

  • This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

GeneCards Summary for TRIM45 Gene

TRIM45 (Tripartite Motif Containing 45) is a Protein Coding gene. Among its related pathways are Interferon gamma signaling and Cytokine Signaling in Immune system. An important paralog of this gene is TRIM71.

UniProtKB/Swiss-Prot for TRIM45 Gene

  • May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Wiki entry for TRIM45 Gene

Additional gene information for TRIM45 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM45 Gene

Genomics for TRIM45 Gene

Regulatory Elements for TRIM45 Gene

Enhancers for TRIM45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H116371 1.8 FANTOM5 ENCODE dbSUPER 9.9 +745.7 745730 9.9 HNRNPUL1 HDGF FOXA2 ARNT ZFP64 ARID4B SIN3A ZNF2 ZBTB7B YY1 ATP1A1-AS1 CD58 TRIM45 ATP1A1 NAP1L4P1 SLC22A15 GC01P116389 GC01P116388
GH01H116877 1.7 FANTOM5 Ensembl ENCODE 10 +243.9 243880 3.1 HDGF PKNOX1 ARNT YBX1 FEZF1 ZNF2 ZNF302 ZNF416 ZNF143 ZNF548 MAN1A2 ATP1A1-AS1 ENSG00000237993 NEFHP1 LINC01525 VPS25P1 PTGFRN CD2 CD101 TRIM45
GH01H116569 1.7 FANTOM5 ENCODE dbSUPER 9.9 +551.9 551859 3.1 HDGF PKNOX1 SIN3A DMAP1 YY1 ZNF766 ZNF207 ZNF143 DEK SP3 MAN1A2 TRIM45 CD58 ATP1A1-AS1 ATP1A1 IGSF3 CD101 TTF2 MIR548AC
GH01H117339 1.3 Ensembl ENCODE 10.1 -217.5 -217499 1.4 HDGF PKNOX1 FEZF1 ZNF2 YY1 ZNF766 CBX5 SP3 REST ZNF592 MAN1A2 ENSG00000271427 TRIM45 CD58 GC01M117313 LINC01525
GH01H117076 1.1 FANTOM5 ENCODE 11.1 +45.3 45274 1.8 ZBTB21 JUN ZSCAN4 INSM2 CEBPG RFX5 FOSL1 HIC1 ZNF366 NFYB TTF2 TRIM45 CD101 MIR942
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TRIM45 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000012058 787 1201 PKNOX1 SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 FOS SP3 CEBPZ

Genomic Locations for TRIM45 Gene

Genomic Locations for TRIM45 Gene
11,533 bases
Minus strand

Genomic View for TRIM45 Gene

Genes around TRIM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM45 Gene

Proteins for TRIM45 Gene

  • Protein details for TRIM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Tripartite motif-containing protein 45
    Protein Accession:
    Secondary Accessions:
    • Q53GN0
    • Q5T2K4
    • Q5T2K5
    • Q8IYV6

    Protein attributes for TRIM45 Gene

    580 amino acids
    Molecular mass:
    64359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRIM45 Gene

    Alternative splice isoforms for TRIM45 Gene


neXtProt entry for TRIM45 Gene

Post-translational modifications for TRIM45 Gene

  • Ubiquitination at Lys371
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM45 Gene

No data available for DME Specific Peptides for TRIM45 Gene

Domains & Families for TRIM45 Gene

Gene Families for TRIM45 Gene

Suggested Antigen Peptide Sequences for TRIM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TRIM/RBCC family.
  • Belongs to the TRIM/RBCC family.
genes like me logo Genes that share domains with TRIM45: view

Function for TRIM45 Gene

Molecular function for TRIM45 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Ontology (GO) - Molecular Function for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with TRIM45: view
genes like me logo Genes that share phenotypes with TRIM45: view

Animal Models for TRIM45 Gene

MGI Knock Outs for TRIM45:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM45 Gene

Localization for TRIM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM45 Gene

Cytoplasm. Nucleus.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TRIM45 gene
Compartment Confidence
nucleus 5
cytosol 5
extracellular 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytokinetic bridge (3)
  • Cytosol (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IDA --
GO:0045171 intercellular bridge IDA --
genes like me logo Genes that share ontologies with TRIM45: view

Pathways & Interactions for TRIM45 Gene

genes like me logo Genes that share pathways with TRIM45: view

Pathways by source for TRIM45 Gene

Gene Ontology (GO) - Biological Process for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0060348 bone development IEA --
genes like me logo Genes that share ontologies with TRIM45: view

No data available for SIGNOR curated interactions for TRIM45 Gene

Drugs & Compounds for TRIM45 Gene

No Compound Related Data Available

Transcripts for TRIM45 Gene

Unigene Clusters for TRIM45 Gene

Tripartite motif containing 45:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM45 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP3: - - - - - - -
SP4: -
SP5: -

Relevant External Links for TRIM45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TRIM45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TRIM45 Gene

Protein differential expression in normal tissues from HIPED for TRIM45 Gene

This gene is overexpressed in Platelet (19.4), Liver, secretome (17.9), and Urine (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM45 Gene

NURSA nuclear receptor signaling pathways regulating expression of TRIM45 Gene:


SOURCE GeneReport for Unigene cluster for TRIM45 Gene:


mRNA Expression by UniProt/SwissProt for TRIM45 Gene:

Tissue specificity: Expressed in skeletal muscle, brain, heart and pancreas.

Evidence on tissue expression from TISSUES for TRIM45 Gene

  • Kidney(4.1)
genes like me logo Genes that share expression patterns with TRIM45: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for TRIM45 Gene

Orthologs for TRIM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TRIM45 33 34
  • 99.08 (n)
(Canis familiaris)
Mammalia TRIM45 33 34
  • 89.02 (n)
(Bos Taurus)
Mammalia TRIM45 33 34
  • 87.53 (n)
(Mus musculus)
Mammalia Trim45 33 16 34
  • 84.6 (n)
(Rattus norvegicus)
Mammalia Trim45 33
  • 84.28 (n)
(Monodelphis domestica)
Mammalia TRIM45 34
  • 58 (a)
(Gallus gallus)
Aves TRIM45 33 34
  • 69.86 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9574 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.14978 33
(Danio rerio)
Actinopterygii trim45 33 34
  • 57.01 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8419 33 34
  • 45.07 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 10 (a)
Species where no ortholog for TRIM45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM45 Gene

Gene Tree for TRIM45 (if available)
Gene Tree for TRIM45 (if available)

Paralogs for TRIM45 Gene

Paralogs for TRIM45 Gene

genes like me logo Genes that share paralogs with TRIM45: view

Variants for TRIM45 Gene

Sequence variations from dbSNP and Humsavar for TRIM45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000093782 -- 117,112,350(+) TGCCC(A/G)CCTGT nc-transcript-variant, reference, synonymous-codon
rs1000108353 -- 117,112,883(+) TAAGG(-/AC)ACAAT intron-variant
rs1000399040 -- 117,119,785(+) TGCCT(A/T)TTCTG intron-variant
rs1000941464 -- 117,107,786(+) TCCTA(C/T)ATCGG downstream-variant-500B, utr-variant-3-prime
rs1001082581 -- 117,114,281(+) TTTCG(C/T)TCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TRIM45 Gene

Variant ID Type Subtype PubMed ID
nsv1009706 CNV gain 25217958

Variation tolerance for TRIM45 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.92; 93.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TRIM45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TRIM45 Gene

Disorders for TRIM45 Gene

Relevant External Links for TRIM45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TRIM45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM45 Gene

Publications for TRIM45 Gene

  1. TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. (PMID: 15351693) Wang Y … Liu M (Biochemical and biophysical research communications 2004) 2 3 4 60
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60

Products for TRIM45 Gene

Sources for TRIM45 Gene

Loading form....