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Aliases for TRIM45 Gene

Aliases for TRIM45 Gene

  • Tripartite Motif Containing 45 2 3 5
  • Tripartite Motif-Containing 45 2 3
  • RNF99 3 4
  • Ring Finger Protein 99 3
  • RING Finger Protein 99 4

External Ids for TRIM45 Gene

Previous GeneCards Identifiers for TRIM45 Gene

  • GC01M116493
  • GC01M116801
  • GC01M117001
  • GC01M117365
  • GC01M117654
  • GC01M115511

Summaries for TRIM45 Gene

Entrez Gene Summary for TRIM45 Gene

  • This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]

GeneCards Summary for TRIM45 Gene

TRIM45 (Tripartite Motif Containing 45) is a Protein Coding gene. Among its related pathways are Immune System and Interferon gamma signaling. An important paralog of this gene is NHLRC4.

UniProtKB/Swiss-Prot for TRIM45 Gene

  • May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Wiki entry for TRIM45 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TRIM45 Gene

Genomics for TRIM45 Gene

Regulatory Elements for TRIM45 Gene

Enhancers for TRIM45 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TRIM45 on UCSC Golden Path with GeneCards custom track

Promoters for TRIM45 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TRIM45 on UCSC Golden Path with GeneCards custom track

Genomic Location for TRIM45 Gene

Chromosome:
1
Start:
117,111,055 bp from pter
End:
117,122,587 bp from pter
Size:
11,533 bases
Orientation:
Minus strand

Genomic View for TRIM45 Gene

Genes around TRIM45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TRIM45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TRIM45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TRIM45 Gene

Proteins for TRIM45 Gene

  • Protein details for TRIM45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H8W5-TRI45_HUMAN
    Recommended name:
    Tripartite motif-containing protein 45
    Protein Accession:
    Q9H8W5
    Secondary Accessions:
    • Q53GN0
    • Q5T2K4
    • Q5T2K5
    • Q8IYV6

    Protein attributes for TRIM45 Gene

    Size:
    580 amino acids
    Molecular mass:
    64359 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for TRIM45 Gene

    Alternative splice isoforms for TRIM45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TRIM45 Gene

Proteomics data for TRIM45 Gene at MOPED

Post-translational modifications for TRIM45 Gene

  • Ubiquitination at Lys 371
  • Modification sites at PhosphoSitePlus

Other Protein References for TRIM45 Gene

No data available for DME Specific Peptides for TRIM45 Gene

Domains & Families for TRIM45 Gene

Gene Families for TRIM45 Gene

Suggested Antigen Peptide Sequences for TRIM45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H8W5

UniProtKB/Swiss-Prot:

TRI45_HUMAN :
  • Belongs to the TRIM/RBCC family.
  • Contains 2 B box-type zinc fingers.
Family:
  • Belongs to the TRIM/RBCC family.
Similarity:
  • Contains 2 B box-type zinc fingers.
  • Contains 1 filamin repeat.
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with TRIM45: view

Function for TRIM45 Gene

Molecular function for TRIM45 Gene

UniProtKB/Swiss-Prot Function:
May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway.

Gene Ontology (GO) - Molecular Function for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with TRIM45: view
genes like me logo Genes that share phenotypes with TRIM45: view

Animal Models for TRIM45 Gene

MGI Knock Outs for TRIM45:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TRIM45 Gene

Localization for TRIM45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TRIM45 Gene

Cytoplasm. Nucleus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TRIM45 Gene COMPARTMENTS Subcellular localization image for TRIM45 gene
Compartment Confidence
nucleus 5
extracellular 4
cytosol 3

Gene Ontology (GO) - Cellular Components for TRIM45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005622 intracellular IEA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA --
genes like me logo Genes that share ontologies with TRIM45: view

Pathways & Interactions for TRIM45 Gene

genes like me logo Genes that share pathways with TRIM45: view

Pathways by source for TRIM45 Gene

Interacting Proteins for TRIM45 Gene

Gene Ontology (GO) - Biological Process for TRIM45 Gene

None

No data available for SIGNOR curated interactions for TRIM45 Gene

Drugs & Compounds for TRIM45 Gene

No Compound Related Data Available

Transcripts for TRIM45 Gene

Unigene Clusters for TRIM45 Gene

Tripartite motif containing 45:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TRIM45 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
SP1: -
SP2:
SP3: - - - - - - -
SP4: -
SP5: -

Relevant External Links for TRIM45 Gene

GeneLoc Exon Structure for
TRIM45
ECgene alternative splicing isoforms for
TRIM45

Expression for TRIM45 Gene

mRNA expression in normal human tissues for TRIM45 Gene

Protein differential expression in normal tissues from HIPED for TRIM45 Gene

This gene is overexpressed in Platelet (19.4), Liver, secretome (17.9), and Urine (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TRIM45 Gene



SOURCE GeneReport for Unigene cluster for TRIM45 Gene Hs.301526

mRNA Expression by UniProt/SwissProt for TRIM45 Gene

Q9H8W5-TRI45_HUMAN
Tissue specificity: Expressed in skeletal muscle, brain, heart and pancreas.
genes like me logo Genes that share expression patterns with TRIM45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein tissue co-expression partners for TRIM45 Gene

Orthologs for TRIM45 Gene

This gene was present in the common ancestor of animals.

Orthologs for TRIM45 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TRIM45 35
  • 87.53 (n)
  • 88.97 (a)
TRIM45 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TRIM45 35
  • 89.02 (n)
  • 91.38 (a)
TRIM45 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Trim45 35
  • 84.6 (n)
  • 86.03 (a)
Trim45 16
Trim45 36
  • 63 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TRIM45 35
  • 99.08 (n)
  • 98.28 (a)
TRIM45 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Trim45 35
  • 84.28 (n)
  • 86.18 (a)
oppossum
(Monodelphis domestica)
Mammalia TRIM45 36
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TRIM45 35
  • 69.86 (n)
  • 63.64 (a)
TRIM45 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9574 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.14978 35
zebrafish
(Danio rerio)
Actinopterygii trim45 35
  • 57.01 (n)
  • 51.37 (a)
trim45 36
  • 51 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG8419 35
  • 45.07 (n)
  • 34.27 (a)
CG8419 36
  • 21 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 10 (a)
OneToMany
Species with no ortholog for TRIM45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TRIM45 Gene

ENSEMBL:
Gene Tree for TRIM45 (if available)
TreeFam:
Gene Tree for TRIM45 (if available)

Paralogs for TRIM45 Gene

Paralogs for TRIM45 Gene

genes like me logo Genes that share paralogs with TRIM45: view

Variants for TRIM45 Gene

Sequence variations from dbSNP and Humsavar for TRIM45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs749902 - 117,118,132(-) CTTCT(A/G)TCCTC nc-transcript-variant, reference, missense
rs3738413 - 117,116,730(+) TCTCC(C/T)GGGCT nc-transcript-variant, reference, missense
rs1289658 - 117,113,466(+) TCACC(A/G)TCACA nc-transcript-variant, reference, missense
rs34863850 - 117,118,198(+) TGAGC(C/T)GTTCT nc-transcript-variant, reference, missense
rs755592 -- 117,117,509(+) TAAAA(A/G)AAACC intron-variant

Variation tolerance for TRIM45 Gene

Residual Variation Intolerance Score: 89.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 11.92; 93.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TRIM45 Gene

Disorders for TRIM45 Gene

Relevant External Links for TRIM45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TRIM45

No disorders were found for TRIM45 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TRIM45 Gene

Publications for TRIM45 Gene

  1. TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. (PMID: 15351693) Wang Y. … Liu M. (Biochem. Biophys. Res. Commun. 2004) 2 3 4 67
  2. The TRIM-FLMN protein TRIM45 directly interacts with RACK1 and negatively regulates PKC-mediated signaling pathway. (PMID: 24681954) Sato T. … Ariga T. (Oncogene 2015) 3
  3. TRIM45 negatively regulates NF-I_B-mediated transcription and suppresses cell proliferation. (PMID: 22634006) Shibata M. … Hatakeyama S. (Biochem. Biophys. Res. Commun. 2012) 3
  4. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PMID: 21143188) Napolitano L.M. … Meroni G. (Biochem. J. 2011) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TRIM45 Gene

Sources for TRIM45 Gene

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