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TRIM45 Gene

protein-coding   GIFtS: 44
GCID: GC01M117654

Tripartite Motif Containing 45

(Previous name: tripartite motif-containing 45)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Tripartite Motif Containing 451 2
Tripartite Motif-Containing 451 2
RING Finger Protein 992 3
RNF992 3
Tripartite Motif-Containing Protein 452

External Ids:    HGNC: 190181   Entrez Gene: 802632   Ensembl: ENSG000001342537   OMIM: 6093185   UniProtKB: Q9H8W53   

Export aliases for TRIM45 gene to outside databases

Previous GC identifers: GC01M116493 GC01M116801 GC01M117001 GC01M117365 GC01M115511


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TRIM45 Gene:
This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional
repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been
described.(provided by RefSeq, Mar 2009)

GeneCards Summary for TRIM45 Gene:
TRIM45 (tripartite motif containing 45) is a protein-coding gene. An important paralog of this gene is TRIM3.

UniProtKB/Swiss-Prot: TRI45_HUMAN, Q9H8W5
Function: May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway

Gene Wiki entry for TRIM45 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_032977.10  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TRIM45 gene promoter:
         HOXA9   HOXA9B   AP-1   SRF (504 AA)   ATF-2   Meis-1b   HNF-4alpha1   Sox9   c-Jun   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTRIM45 promoter sequence
   Search Chromatin IP Primers for TRIM45

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TRIM45


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p13.1   Ensembl cytogenetic band:  1p13.1   HGNC cytogenetic band: 1p13.1

TRIM45 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TRIM45 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M117654:  view genomic region     (about GC identifiers)

Start:
117,653,677 bp from pter      End:
117,665,209 bp from pter
Size:
11,533 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TRI45_HUMAN, Q9H8W5 (See protein sequence)
Recommended Name: Tripartite motif-containing protein 45  
Size: 580 amino acids; 64359 Da
Developmental stage: Expressed in brain, lung, skeletal muscle, heart and intestine in 80-day old embryo
1 PDB 3D structure from and Proteopedia for TRIM45:
2DS4 (3D)    
Secondary accessions: Q53GN0 Q5T2K4 Q5T2K5 Q8IYV6
Alternative splicing: 2 isoforms:  Q9H8W5-1   Q9H8W5-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TRIM45: NX_Q9H8W5

Explore proteomics data for TRIM45 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys371
  • Modification sites at PhosphoSitePlus

  • See TRIM45 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001139107.1  NP_079464.2  

    ENSEMBL proteins: 
     ENSP00000431261   ENSP00000256649   ENSP00000358476   ENSP00000358473   ENSP00000474935  

    TRIM45 Human Recombinant Protein Products:

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    Novus Biologicals TRIM45 Protein
    Novus Biologicals TRIM45 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for TRIM45

     
    Search eBioscience for Proteins for TRIM45 

    TRIM45 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    LSBio Antibodies in human, mouse, rat for TRIM45

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    Search eBioscience for ELISAs for TRIM45 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    TRIM: Tripartite motif containing / Tripartite motif containing
    RNF: RING-type (C3HC4) zinc fingers

    Selected InterPro protein domains (see all 9):
     IPR017907 Znf_RING_CS
     IPR001298 Filamin/ABP280_rpt
     IPR001841 Znf_RING
     IPR014756 Ig_E-set
     IPR017868 Filamin/ABP280_repeat-like

    Graphical View of Domain Structure for InterPro Entry Q9H8W5

    ProtoNet protein and cluster: Q9H8W5

    2 Blocks protein domains:
    IPB000315 B-box zinc finger signature
    IPB001841 Zn-finger


    UniProtKB/Swiss-Prot: TRI45_HUMAN, Q9H8W5
    Similarity: Belongs to the TRIM/RBCC family
    Similarity: Contains 2 B box-type zinc fingers
    Similarity: Contains 1 filamin repeat
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with TRIM45           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TRI45_HUMAN, Q9H8W5
    Function: May act as a transcriptional repressor in mitogen-activated protein kinase signaling pathway

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with TRIM45           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Trim45):
     homeostasis/metabolism  mortality/aging  nervous system  skeleton  vision/eye 

    Find genes that share phenotypes with TRIM45           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TRIM45
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TRIM45

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TRIM45
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TRIM45

    miRNA
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    5 qRT-PCR Assays for microRNAs that regulate TRIM45:
    hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-138-2* hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTRIM45 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TRIM45
    Predesigned siRNA for gene silencing in human, mouse, rat TRIM45

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM45 (NM_025188)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM45

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM45


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TRI45_HUMAN, Q9H8W5: Cytoplasm. Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with TRIM45           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM45: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TRIM45

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for TRIM45 (Q9H8W53 ENSP000002566494) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    UBE2D1ENSP000003630194STRING: ENSP00000363019
    UBE2D2ENSP000003817174STRING: ENSP00000381717
    UBE2D3ENSP000003497224STRING: ENSP00000349722
    UBE2D4ENSP000002224024STRING: ENSP00000222402
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0060348bone development IEA--

    Find genes that share ontologies with TRIM45           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TRIM45 (TRI45)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TRIM45 gene (2 alternative transcripts): 
    NM_001145635.1  NM_025188.3  

    Unigene Cluster for TRIM45:

    Tripartite motif containing 45
    Hs.301526  [show with all ESTs]
    Unigene Representative Sequence: AY669488
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000497970 ENST00000256649(uc001egz.2) ENST00000369464(uc009whe.2)
    ENST00000369461 ENST00000485032
    miRNA
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    Block miRNA regulation of human, mouse, rat TRIM45 using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate TRIM45:
    hsa-miR-124 hsa-miR-539 hsa-miR-506 hsa-miR-138-2* hsa-miR-1305
    SwitchGear 3'UTR luciferase reporter plasmidTRIM45 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat TRIM45
    Clone
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    OriGene ORF clones in mouse, rat for TRIM45
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TRIM45 (NM_025188)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TRIM45
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TRIM45
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for TRIM45
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TRIM45
      QuantiTect SYBR Green Assays in human, mouse, rat TRIM45
      QuantiFast Probe-based Assays in human, mouse, rat TRIM45

    Additional mRNA sequence: 

    AK023243.1 AK222901.1 AY669488.1 BC034943.2 

    2 DOTS entries:

    DT.406608  DT.100835091 

    Selected AceView cDNA sequences (see all 39):

    AI874259 AY669488 AI253072 NM_025188 CR595070 CR602755 AA057266 BX103245 
    BX383989 AI199235 AI972066 BG722669 BU846471 BX444521 BX383988 BC034943 
    BQ881123 AK023243 BX452649 AV745626 BE730280 AU132216 BU618486 BM544980 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TRIM45    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c
    SP1:                                            -                                       
    SP2:                                                                                    
    SP3:        -     -     -     -     -     -     -                                       
    SP4:              -                                                                     
    SP5:              -                                                                     


    ECgene alternative splicing isoforms for TRIM45

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TRIM45 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TRIM45 Expression
    About this image

    TRIM45 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TRIM45 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.301526

    UniProtKB/Swiss-Prot: TRI45_HUMAN, Q9H8W5
    Tissue specificity: Expressed in skeletal muscle, brain, heart and pancreas

        Pathway & Disease-focused RT2 Profiler PCR Array including TRIM45: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TRIM45

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TRIM45 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Trim451 , 5 tripartite motif-containing 451, 5 84.6(n)1
    86.03(a)1
      3 (43.85 cM)5
    2296441  NM_194343.21  NP_919324.21 
     1009222025 
    chicken
    (Gallus gallus)
    Aves TRIM451 tripartite motif containing 45 69.86(n)
    63.64(a)
      769776  XM_004938162.1  XP_004938219.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.149782 Xenopus laevis transcribed sequence with weak similarity more 80.02(n)    BJ046674.1 
    zebrafish
    (Danio rerio)
    Actinopterygii trim451 tripartite motif containing 45 57.01(n)
    51.37(a)
      558117  XM_681301.5  XP_686393.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84191 CG8419 45.07(n)
    34.27(a)
      34118  NM_135349.3  NP_609193.1 


    ENSEMBL Gene Tree for TRIM45 (if available)
    TreeFam Gene Tree for TRIM45 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TRIM45 gene
    TRIM32  TRIM712  TRIM562  TRIM22  

    Find genes that share paralogs with TRIM45           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TRIM45 (see all 319)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1810988391,2
    --115511297(+) AAAAAA/GAAAAA 2 -- ds50010--------
    rs38417071,2
    C--115512775(-) TGTTA-/GTTA  
            
    TTCAC
    2 -- ut310--------
    rs1458492841,2
    --115524408(+) CACCTA/GGCTAA 2 -- us2k10--------
    rs616285311,2
    C--117653312(+) AAAAA-/A/GGAACC 2 -- ds50010--------
    rs113559001,2
    C--117665664(+) ATATG-/A/A   
       A
    /AAA
    AAAAA
    4 -- us2k1 cds1 trp30--------
    rs1901237961,2
    --117721881(+) TCTCAC/GCTTAC 2 -- ds50010--------
    rs109232061,2
    C,F,A--117721988(+) GCAAGA/GCTCTG 2 -- ds50015Minor allele frequency- G:0.37NA WA 128
    rs109232071,2
    C,F,A,H--117722084(+) CAGAAG/AGAGTG 2 -- ds500125Minor allele frequency- A:0.19NS EA NA WA 2772
    rs1450025681,2
    --117722172(+) AAAGAC/GGCTGA 2 -- ds50010--------
    rs13255101,2
    C,F,H--117722207(+) AGAACA/GCAGAG 2 -- ds500199Minor allele frequency- T:0.00NS NA EA PA EU CA WA 6110

    HapMap Linkage Disequilibrium report for TRIM45 (117653677 - 117665209 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TRIM45: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TRIM45
    DNA2.0 Custom Variant and Variant Library Synthesis for TRIM45

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609318    OMIM disorders: --


    Find genes that share disorders with TRIM45           About GenesLikeMe


    Export disorders for TRIM45 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TRIM45 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TRIM45)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. TRIM45, a novel human RBCC/TRIM protein, inhibits transcriptional activities of ElK-1 and AP-1. (PubMed id 15351693)1, 2, 3 Wang Y.... Liu M. (Biochem. Biophys. Res. Commun. 2004)
    2. Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry. (PubMed id 17370265)1, 2 Denis N.J.... Figeys D. (Proteomics 2007)
    3. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. TRIM45 negatively regulates NF-I_B-mediated transcription and suppresses cell proliferation. (PubMed id 22634006)1 Shibata M....Hatakeyama S. (Biochem. Biophys. Res. Commun. 2012)
    7. Functional interactions between ubiquitin E2 enzymes and TRIM proteins. (PubMed id 21143188)1 Napolitano L.M....Meroni G. (Biochem. J. 2011)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (EMBO J. 2009)
    9. Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties. (PubMed id 18673550)1 Sardiello M....Meroni G. (BMC Evol. Biol. 2008)
    10. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80263 HGNC: 19018 AceView: TRIM45 Ensembl:ENSG00000134253 euGenes: HUgn80263
    ECgene: TRIM45 H-InvDB: TRIM45

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TRIM45 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TRIM45 gene:
    Search GeneIP for patents involving TRIM45

    GeneCards and IP:
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